LOCUS       NZ_CP025957            26291 bp    DNA     circular CON 13-OCT-2024
DEFINITION  Paenibacillus polymyxa strain HY96-2 chromosome, complete genome.
ACCESSION   NZ_CP025957
VERSION     NZ_CP025957.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5745779)
  AUTHORS   Luo,Y., Zhang,D., Cheng,Y. and lI,Y.
  TITLE     Complete genome sequence of Paenibacillus polymyxa HY96-2
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5745779)
  AUTHORS   Luo,Y., Zhang,D., Cheng,Y. and lI,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JAN-2018) East China University of Science and
            Technology, Laboratory of Marine Biochemical Engineering, Meilong
            Road No. 130, Shanghai 200237, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3.0
            Expected Final Version            :: no
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002893885.1-RS_2024_10_12
            Annotation Date                   :: 10/12/2024 01:33:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,010
            CDSs (total)                      :: 4,854
            Genes (coding)                    :: 4,742
            CDSs (with protein)               :: 4,742
            Genes (RNA)                       :: 156
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 110
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 112
            CDSs (without protein)            :: 112
            Pseudo Genes (ambiguous residues) :: 0 of 112
            Pseudo Genes (frameshifted)       :: 76 of 112
            Pseudo Genes (incomplete)         :: 39 of 112
            Pseudo Genes (internal stop)      :: 14 of 112
            Pseudo Genes (multiple problems)  :: 16 of 112
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:53:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5420804
            Orig. end                         :: 5447095
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP025957.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26291
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="20"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26291
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26291
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16291](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16291)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(221..1234)
                     /locus_tag="C1A50_RS23520"
                     /old_locus_tag="C1A50_5014"
     CDS             complement(221..1234)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312501.1"
                     /locus_tag="C1A50_RS23520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5014"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_016822717.1"
                     /transl_table=11
                     /translation="MKKPTIEDVAQKAGVSKSTVSQFLNKRYKYMSDQTKDRIAEVIQE
                     LNYQPNGLARSLKQNRTFMVGVIVANIDYTLSIQSIRAIEEELQRFGIQVIICNADENP
                     DKESQYIEMLKARQVDGLIIFPTGKHADIYNQLIREKYPLVFLDRLVDGVNTRSLLLDN
                     EMAIKLAIQELVAHKHERIALITLPLGLNRITPRVERLSGYKKALEEHGLPFREEYMHS
                     VPREEIQQTLKELFQLPEPPTALLAGNDIVLAEVLKYVNARRIRIPAELSIIGIDDAEF
                     AHIYNPPITTITQPIADMGKQAAKTLLSSIEEGGESVPIIYRFVPDINRGESVKTL"
     misc_feature    complement(1290..1306)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.7"
                     /tool="antismash"
     misc_feature    1418..1434
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 24.28"
                     /tool="antismash"
     gene            complement(1519..2928)
                     /locus_tag="C1A50_RS23525"
                     /old_locus_tag="C1A50_5015"
     CDS             complement(1519..2928)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312502.1"
                     /locus_tag="C1A50_RS23525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5015"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_016822716.1"
                     /transl_table=11
                     /translation="MTTRALKNGSVLSEAKELNLFRLTWPIFLELFLFMLMGSVDTFML
                     SSVSDNAVSGVGASNQIISIAILVLEVIGNGAAIVVAQYIGSKKLVEAAQVTGTAITLN
                     LMVGLLLSVIFLVFGTHMLQWLNVQGDILTYAESYMSIVGGAIFLQALINSLAATIRTH
                     GFTKETMYVSVFMNVIHVVGNYVLILGHWGMPALGVEGAAISTVGSRFICLLIFFWLMY
                     RVTEVRVEWKYYVHLSKKFISKILRIGVPSALESIMYQSCQLIFTLYVTYLGAEAMATR
                     QYANNISSYIYLFSMAVGMGTAIVVGRLVGAREKDTAYKRVLSSVKWALLVTVIIDAIV
                     IFFRVPLLGLFTENPEIIRLGAQVILLSILLETGRTTNIVIINSLRAAGDAKFPVFMGL
                     ISMVCMSLPLGYLLVFKLDMGLAGVWLAIAADEWTRAVIMYARWRSRLWEKHSLVEHDT
                     PDQPATPVPAH"
     gene            3285..4292
                     /locus_tag="C1A50_RS23530"
                     /old_locus_tag="C1A50_5016"
     CDS             3285..4292
                     /EC_number="1.3.1.95"
                     /GO_function="GO:0016655 - oxidoreductase activity, acting
                     on NAD(P)H, quinone or similar compound as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (22-199). E-value: 3e-26. Score:
                     84.2. Matches aSDomain:
                     nrpspksdomains_C1A50_RS23530_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312503.1"
                     /locus_tag="C1A50_RS23530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5016"
                     /product="acryloyl-CoA reductase"
                     /protein_id="WP_017428649.1"
                     /sec_met_domain="ADH_N (E-value: 3.3e-05, bitscore: 21.9,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 8.7e-14, bitscore:
                     49.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQSFHALVVDQTQDGEVQAEVRSLETGSLPAGEVLIRVAYSSIN
                     YKDGLAARKDGNIVKAYPFVPGIDCSGTVVSSEDSRFSEGQAVLVTGYGLGVSQFGGFS
                     QYARVPADWVVPLPDGLTLREAMIFGTAGFTAALSLYRLEQNGVAPEKGKVLVTGATGG
                     VGGAAIALLHKRGYHVVASSGKAESHDYLKTLGAAEVISREEVYDGAESIRPLGKQLWQ
                     AAVDPVGGKPLASLLSQIAYNGSVAVSGLTAGTKLPTTVLPFILRGVNLLGIDSVFCPY
                     DTRVAIWKQLSSDWKPEQLEQLVEREIGLADLPSALEDILAARSQGRTIVRLAD"
     aSDomain        3351..3881
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C1A50_RS23530_PKS_ER.1"
                     /evalue="3.00E-26"
                     /label="C1A50_RS23530_PKS_ER.1"
                     /locus_tag="C1A50_RS23530"
                     /protein_end="199"
                     /protein_start="22"
                     /score="84.2"
                     /tool="antismash"
                     /translation="RSLETGSLPAGEVLIRVAYSSINYKDGLAARKDGNIVKAYPFVPG
                     IDCSGTVVSSEDSRFSEGQAVLVTGYGLGVSQFGGFSQYARVPADWVVPLPDGLTLREA
                     MIFGTAGFTAALSLYRLEQNGVAPEKGKVLVTGATGGVGGAAIALLHKRGYHVVASSGK
                     AESHDYLKTLGAAE"
     CDS_motif       3744..3797
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C1A50_RS23530_0001"
                     /evalue="3.70E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="C1A50_RS23530"
                     /protein_end="171"
                     /protein_start="153"
                     /score="16.3"
                     /tool="antismash"
                     /translation="KVLVTGATGGVGGAAIAL"
     misc_feature    4437..4453
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.69"
                     /tool="antismash"
     gene            4550..5110
                     /locus_tag="C1A50_RS23535"
                     /old_locus_tag="C1A50_5017"
     CDS             4550..5110
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013373621.1"
                     /locus_tag="C1A50_RS23535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5017"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_045244708.1"
                     /transl_table=11
                     /translation="MQSNRELFDLYQRDVYRTCYYMVHNASDAEDLTQEVFITLFHSNR
                     EHIEQLKAWIMKVTVNHCLNHLKRRKSLHLKVAANPHLFTGTEGKPVDRQVEERESAEE
                     WAIYMNRLPAKIRAVLTLRYMHDFTLAEISKLLEIPLGTVKSRTHKGLKLMEQILRGAD
                     AQIPKLEGENYEQRRKGIEAQVK"
     misc_feature    4572..4585
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.57"
                     /tool="antismash"
     gene            5070..6755
                     /locus_tag="C1A50_RS23540"
                     /old_locus_tag="C1A50_5018"
     CDS             5070..6755
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019688920.1"
                     /locus_tag="C1A50_RS23540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5018"
                     /product="DUF4179 domain-containing protein"
                     /protein_id="WP_045244709.1"
                     /transl_table=11
                     /translation="MNNVEKALKRKLNEDSELAHPNFDEMWNRMEQAGHTALTPTGVSD
                     SFTPHQHRNWRKIAIAASLSALLVAVPVYAAIHYNWGNLLHGRSGIETALAQDLGQPLE
                     QSVTKDGIKLTLHTAIVDENRTVILYSLEVGKRADNEFWNVKGVSLKNAVGKSSEGEYS
                     FQQWDEKNQRYNGYFESDWTPQQETENVRLTVDHIELTSVQELDLPLDITSPQKQTFRL
                     DRNGLQDMKVQVFEQGKDKLMLSSAITFDSSIPKEWDNPQIIAYKDGKPVNPQSGGTFG
                     TPGEDGEYTAQQYFTKGDIPEGQTTFKLQYAQTEKSIHEPLNFDLQLSKKKMESGTIKS
                     VLNTPLENGNPNFMLEQMIVTPTQIRVTIRSEKKFAMLPYQKYFLSVNGTTLEGNRWSS
                     PDQDHDLNTIRFERPAHLAITRDTPITFTGKYKVTTHSDDKTPQHLTDISEQKQTITTQ
                     IGGYPVKWTYYKQGADLFVETESEDTHFGGINQTHIGLGKERMIGKPITANFAGDGNNK
                     AVDVYKNFKGKEASIYMFYYTTDEPEAETSVPLQPLTSNSQASK"
     gene            complement(6868..7692)
                     /locus_tag="C1A50_RS23545"
                     /old_locus_tag="C1A50_5019"
     CDS             complement(6868..7692)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426161.1"
                     /locus_tag="C1A50_RS23545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5019"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_016822712.1"
                     /transl_table=11
                     /translation="MKTSRRTNWPVLILVALGTIFILFPLYMTVTIALKNPEQMAHSAF
                     AFPTELHWENFSRAVEMTHFFSAFQNSVMVTTSTVILTLLTNSMVAYAIARNMQRRFFK
                     GLYFYFVSAMFIPFPIIMLPIVKLASGLHMTNLLGLIVLHTVYGLAFNVFVYVGYIRSI
                     PVALEEAATVDGATTWGTFWRIIFPLMAPISATVGILTCLSTYNDFLLPLIIISDAEQY
                     TLPLVQYVFQGQFNTDFNLAFASYLMALLPMIIVYLIAQKWIINGVTQGSVK"
     gene            complement(7692..8558)
                     /locus_tag="C1A50_RS23550"
                     /old_locus_tag="C1A50_5020"
     CDS             complement(7692..8558)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013373624.1"
                     /locus_tag="C1A50_RS23550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5020"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_016822711.1"
                     /transl_table=11
                     /translation="MNKRLTTFYWMTVPAVLLFFVFLTLPALQGFYYSLTNWNGFGHQY
                     HFVGFKNYINLFQDDNVGNAYWFTFKFAIVVTIAINILSLLIAMGLNAKIRFRNFFRGI
                     YFLPNILSVLIVGYIFNYLFSNVFTIWGQNLGISSLSTNILGSEQLAWVGVVIVAVWQG
                     IAFNTILYLAGLQTIPTSLYEASNLDGAGKWREFWSITFPLIAPFFTINMVLAMKNSLM
                     VFDQIVALTNGGPGRATQSISHLIYTGGFRGGEFAYQSANSVIYFIVIAIISILQLRFL
                     QRREMDN"
     gene            complement(8575..9807)
                     /locus_tag="C1A50_RS23555"
                     /old_locus_tag="C1A50_5021"
     CDS             complement(8575..9807)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016822710.1"
                     /locus_tag="C1A50_RS23555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5021"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_019688922.1"
                     /transl_table=11
                     /translation="MWNGVKRLSALAAILLLTIVVSACNKGDASGKVQIEFFQNKPEAK
                     GSFDKLIAQFNQEHPGIEVTQVNPPEAETVLLTRVVKNDVPDIVGLGATDTYSILAQSG
                     IFTDLANTELPRTVDPIYLKMLKDVTGVDPVYGIPYAANANGVMYNKKLFREMGLQVPK
                     TWDELIATAQKIKAAGKIPFYFTYKDDWQTNLPFNALGPNLVGIDFFLQRRENQVTFQD
                     KYREVAEKQLELLKYGHSDNFGKNYADGNRAFANGQGLMYIQGSWAISEIRKANPKVEL
                     GFFPFPTGNDAKAVKLVSGIDTLLAVSESTPHKKEAEEFIAFLLKPENSKQYITEQTLF
                     SAVKGVTQDDPSVAELLPYFKSGRVIDFADHYIPKAVQLNSIVQAFLQNGDIDAYLAKL
                     DREWNKVANRR"
     gene            complement(10001..11383)
                     /locus_tag="C1A50_RS23560"
                     /old_locus_tag="C1A50_5022"
     CDS             complement(10001..11383)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="C1A50_RS23560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5022"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_045244710.1"
                     /sec_met_domain="LANC_like (E-value: 1e-55, bitscore:
                     187.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTISYTCDNWIPVKGEMKNKISTLLREITERYRNPDQVRLWMKK
                     IPPIEADGVIMERWADESLGSGFTGICLLMGQLDYLYPKNGWDIVGHQYLERIRMVVEQ
                     KGVHDLSLYSGLAGIMLAIYSLSRKGTRYQGMLDALASWFEEAALQSLALHRIEWEKGE
                     LRMSQYDTISGFAGVGRIAMLFLNRPGMQMVWEQTMDLFHVMCGEKNLNGHTVPAWHIS
                     SEHQFQEDEKLQYPQGNFNLGISHGIAGPLCFLSLSALHGVDASPLMNDIHRLGKFIHH
                     WRVQDVEGIIWPGRISFGEWLDGQLLSGSTRNYRDSWCYGVPGIARSIWLAGQAVHNEE
                     WLETGLSAYLDIEKRLHRKGGLSSATLCHGIGGLLHLVQRMYSDTSHEQLGRIRDRLLE
                     DVLDMFDANSLFGFYDHSLLDGRLAEVDEAGFLNGSAGVALVLASLIGDQNPDWDAAFL
                     IR"
     gene            complement(11385..13262)
                     /locus_tag="C1A50_RS23565"
                     /old_locus_tag="C1A50_5023"
     CDS             complement(11385..13262)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="C1A50_RS23565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5023"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_052679230.1"
                     /transl_table=11
                     /translation="MTDIQAKMNLESSTIWRSVRQGLKLFSLVFGMNKTYMVSSIFLHI
                     LQGLMPVLTLIIMQNLLNSIVSFGTQGISLIMLQFGIFIVIHVLKSVVTMSQTFVEGTL
                     ESVLSKSLNLMIGKKSSSLGLADYENSEINDQLKRASQEASYRPYQLYTQMAGILSSMV
                     TMVSSATLILLWKWWVVIILFGISLVSVYSIFKLNKEQFEIYMNRTPLYRESWYMTYLL
                     TNDRAVKEVKIFNMSSYLLKRYEDLLQRFFVEDRRILGKRVTITFMYSLLELAVLLGVV
                     WVAIRETFEKKILVGSLYGYIQAIMLTQSQMQALIQGIVQFSQNNLYMEQLFLFLQLPT
                     SDPVRQQKEQALPINRKKNEDFCIEQICIEGVSFTYSGKTVPSIRDIHLTVNRGQTIAI
                     VGKNGSGKSTLMKVLMQLYSNYEGVFKINGLPVQDYDLHQVQDKIGVVFQDFMHYEMSA
                     RHNIGFGSLERLEKDEELIQAARYAAIDQIITELPQGLDTQLGKWFEDGFQLSGGQWQR
                     IAIARAFLRQADIYILDEPSSFLDPVAERDLLKLFLELMKDSIGIFITHRISSARLADK
                     IVVMDNGGIVEQGTHRELMLLDGLYAEMYNIQASSFNDEEALAETGGRV"
     gene            complement(13259..16291)
                     /locus_tag="C1A50_RS23570"
                     /old_locus_tag="C1A50_5024"
     CDS             complement(13259..16291)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="C1A50_RS23570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5024"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_103042620.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.2e-176,
                     bitscore: 586.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.7e-12,
                     bitscore: 46.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.2e-35, bitscore:
                     119.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELSRDPFIREALAASSPTLLESLVHISNHENPRKQGQVIKAFMR
                     YIIRMITRPTPFGLLSGITYGRFGERSQLFLQGTDTFKKRARPDMEWLMKAVELVESRK
                     EIVRQLRVRSNKLIYRQGNRAKIPYTTRHGSMNDGEDQSVSVRITQVFDCVMAASSAFI
                     PFLDLVDHLNKTFESANIEVIERYVWQLFEQEFLISELIPPTTTTEPLSYIRSVLKPVT
                     GIEELKEDLDTIADTSAKYNHLPIGQGEQLLESLRQKMNKMFSAKSSLQIDLSLEDRGI
                     ILPQSIRKDIECVAELLTKLSTRENRPLNEFCVEFLEKYGPYREVPLLDLLDEDTGLGA
                     PAGYKHPMSRRVRLQDMSPSKSRSHQEKLLFQWFVSAMHEGKHEIVLTDNMIDELIKGH
                     DTEKWLAAPSMELFFQLITSDQEALDQGEYTLLLAPNQGSDAAGKTFGRFMDLFGEPFN
                     DIFSSIQSEEQRLQPGKLLAGISYLPSSGRSANVVLTKQTRPYEIAIGANHTMPEDRQI
                     HISDLVVGVRNDHFYLKSKSRNREVIASSGHMLNAELTPNIYRFLVEVSDNSYRHWSPM
                     EWGFVAHAPFTPRLRYKHIILYPGTWRIASSSSKKMADFAEEIRLFQEKWNIPRYVYMI
                     ESDNRILLDMDHPLHIEQICRDLQSKGKVTLIEHIGGLDNSPVSCGKGHLTAEFVCPLV
                     RNQAEDTQHFVEETAASLELVAKENEQQPTKADYTYLPGESWFYAKLYGINSRQNEFIG
                     GYWEEFVRKHQDNGTILQAYFIRYADPDKHLRVRFELSKNRTADGFLSTFHKWTEMLLH
                     EGMIARVVIDTYEPEIERYGGSKPMAWAERMFSCDSEVTAKLVHLIRFNQVSLEEDIIA
                     TLSVINLLYQFGYHEKDAFNLLNRYFDVKEYLENFRKERKFFLQWFASDQEISQSIQSN
                     LQAIESIFKIRREAVKQYSHVLYEHETGGLSTNTREDIVFSVIHMHLNRLLGIDRDRER
                     KIMIMARHALNSLVQYRGNRQ"
     aSDomain        complement(15680..15961)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C1A50_RS23570_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="9.60E-15"
                     /identifier="RREFam001.1"
                     /label="C1A50_RS23570"
                     /locus_tag="C1A50_RS23570"
                     /protein_end="204"
                     /protein_start="110"
                     /score="46.1"
                     /tool="antismash"
                     /translation="RVRSNKLIYRQGNRAKIPYTTRHGSMNDGEDQSVSVRITQVFDCV
                     MAASSAFIPFLDLVDHLNKTFESANIEVIERYVWQLFEQEFLISELIPP"
     gene            complement(16462..17229)
                     /locus_tag="C1A50_RS23575"
                     /old_locus_tag="C1A50_5025"
     CDS             complement(16462..17229)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312509.1"
                     /locus_tag="C1A50_RS23575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5025"
                     /product="ABC transporter permease"
                     /protein_id="WP_090888938.1"
                     /transl_table=11
                     /translation="MSGIWLSELERIWNRKSTFLLYIAMLLIIFVNIWSLKTNGTMRFR
                     FGEGTVVVNNLNLPWLMMSEISLFLILAMLPILYVDQLGGDLHSGAYRLYVLRPYRRFQ
                     FWLGKLLALSVTTAIFTGTALVIGIVAGWLLFPHTSTFFKYGSGVISPSSDAIPYTLAF
                     YLILTLACVAKLLLVSAVCLFISRPLFAFIAIFVLSVALYQVVRPLVLLMDPFQQIMLA
                     LRVEGSFKFWMCLIAIILVGSVISFVRWQKKII"
     gene            complement(17242..18042)
                     /locus_tag="C1A50_RS23580"
                     /old_locus_tag="C1A50_5026"
     CDS             complement(17242..18042)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312510.1"
                     /locus_tag="C1A50_RS23580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5026"
                     /product="ABC transporter permease"
                     /protein_id="WP_044786940.1"
                     /transl_table=11
                     /translation="MKTLVYSEFERLWRRKWFWLLVLCTPVLVYSTGIYIQHTLRIPVK
                     DLSKIFIVAGLRENLYLICNFAVATLVAAVFTEEFRSGQLRLLFVRRFTRGQIFWSKLL
                     VVNTSILLLLIVYAVSSQVIVVFWKFSHNINGTDIFGQIWSQVFEYYGWAFASLLAISS
                     LYSFIAMCSKSVTYAIGICMTYNLGVLLFDPLYMKLATLFSSIPLLKNLIPFLLIPYLQ
                     YKGLDQSLIWNWSVNGAIVIAVLFHLILFTGWAYRRFTTDDYLY"
     gene            complement(18039..18767)
                     /locus_tag="C1A50_RS23585"
                     /old_locus_tag="C1A50_5027"
     CDS             complement(18039..18767)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312511.1"
                     /locus_tag="C1A50_RS23585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5027"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_045244713.1"
                     /transl_table=11
                     /translation="MTDFLLEVKQVSKTVGKRSLLNNISFELEKGKIYGFIGPNGAGKT
                     TMMRIMTGLMQPTSGSVKIASYNIQTDREKALSKVGAIIESPVFFDYMTGRQVLRNLSR
                     LHLGVASSDREKHIKELLERVGLENRGDDKVKTYSLGMKQRLGIAQSMLGNPELLLLDE
                     PSNGLDPMGMRELRDIILRLRDSDNYAFFVSSHLLDELQQMCDELIVIKEGTLIWKGAA
                     DQLIKDGQRLEDAFMGLMGL"
     gene            complement(18937..19113)
                     /locus_tag="C1A50_RS25095"
     CDS             complement(18937..19113)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="C1A50_RS25095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_113050054.1"
                     /sec_met_domain="TIGR03731 (E-value: 8.2e-08, bitscore:
                     30.3, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAENLFDLDIQVNKSQGSVEPQVLSIVACSSGCGSGKTAASCVET
                     CGNRCFTNVGSLC"
     CDS_motif       complement(19048..19113)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MAENLFDLDIQVNKSQGSVEPQ"
                     /locus_tag="C1A50_RS25095_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(18937..19047)
                     /prepeptide="core"
                     /locus_tag="C1A50_RS25095_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="11.80"
                     /molecular_weight="3323.8"
                     /monoisotopic_mass="3321.5"
                     /core_sequence="VLSIVACSSGCGSGKTAASCVETCGNRCFTNVGSLC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAENLFDLDIQVNKSQGSVEPQ"
                     /leader_location="[19047:19113](-)"
                     /alternative_weights="3341.8"
                     /alternative_weights="3359.8"
                     /alternative_weights="3377.9"
     misc_feature    19345..19361
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 26.05"
                     /tool="antismash"
     misc_feature    complement(19363..19375)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 22.66"
                     /tool="antismash"
     misc_feature    complement(19406..19415)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     gene            complement(19565..21649)
                     /gene="abc-f"
                     /locus_tag="C1A50_RS23595"
                     /old_locus_tag="C1A50_5028"
     CDS             complement(19565..21649)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="abc-f"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016822707.1"
                     /locus_tag="C1A50_RS23595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5028"
                     /product="ribosomal protection-like ABC-F family protein"
                     /protein_id="WP_044786942.1"
                     /transl_table=11
                     /translation="MYIVNGQQLKKYHAANLILDGATFDIHKGEKVGLIGRNGSGKTTL
                     LRLIARLSRPDEGQLVIAKDTKIGYLPQIPAEFESFTVYETLAYAYRELKDCRNQMTTL
                     EREMSDPVVAANPELLEKLLQTYASLQERFERNGGYEMDASMDQIADGLGIPKAMYTRN
                     FGSLSGGEKTKIALASQLIGRPDLLLLDEPTNHLDLKGLEWLEQFLQGYAGACVVVSHD
                     RYFLDRVAGKMIELEDGEAFTYYTNYSGYVKEKEERLLLQFEDYKEQQKRIKKMRETIR
                     RLEEWGRNGDNEKFFKKAASIRKALERMELVKRPVLDPQGAEFHLKLEDRSGRRVLQFE
                     DITKAYGERQILNGATGSLEFGEKVALLGNNGAGKTTLLKLLLGQESVDAGTVQWGARV
                     EYGYLAQQERERNSRATVLAYFKEEAGLDEGEARGQLAKYLFYGADVFKPVSMLSGGEW
                     SRLRLALLVMKKPNLLVLDEPTNHLDIDSREALEEALGTYTGTVLAISHDRYFVNKLAG
                     RVWELENGKLSFYLGGFDEYRAKKRELENAHSQRGADAGVRSASAGRAASGGGSGAGLA
                     TPASAASNDAGTAARTGATTGADASRARSGAAGRLGASDARSGARGAKAAKPSRSPAVS
                     RERLERAIAAKEAALAATDAELELLGTSSDTARMAELWDVRERLQAELDTLLGEWVELE
                     "
     gene            complement(21753..21896)
                     /locus_tag="C1A50_RS25335"
                     /old_locus_tag="C1A50_5029"
     CDS             complement(21753..21896)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007432937.1"
                     /locus_tag="C1A50_RS25335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5029"
                     /product="RAxF-45 family protein"
                     /protein_id="WP_016822706.1"
                     /transl_table=11
                     /translation="MNHEMLNNRISQLPIAMAGIVHAFPYNGRSLSNFNHTVVNIARRR
                     LP"
     gene            complement(21976..23154)
                     /locus_tag="C1A50_RS23600"
                     /old_locus_tag="C1A50_5030"
     CDS             complement(21976..23154)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019688926.1"
                     /locus_tag="C1A50_RS23600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5030"
                     /product="MFS transporter"
                     /protein_id="WP_045244714.1"
                     /transl_table=11
                     /translation="MNFKVVILTIATFTVGLVELIIGGVLPQIAQDLNVSVSTAGQLIM
                     IYALVYAIAGPTLLALTAKIERKRLYLWSMFIFILGSLLAFWSPNYAVLFISRIITAAS
                     GSLIVTLSLTIAVKVVSKAYQARVLGVISMGVSSSIVLGIPAGVLIGNAFGWRVLFLII
                     ALLTVVSMIIMHLFMERIPTEHVVPMREQLKSLKNVKVISAHLVTTLTLAGHYTLYAYF
                     TPFLENLMGLNASWVSVAYFVFGLAAVSGGFIGGSLADRFGTAKSILIVVGVFIAVMFL
                     LPFSIHSVYMFAPLLIIWGILSWALSPPMQSYLIENAPESGSIQQSFNFSALQVGIALG
                     SALGGVVIENSESVATNAWVGGTFVIVAFVCGVFSITRAGTSQTVRGHHSVS"
     regulatory      complement(23223..23322)
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(23378..24337)
                     /locus_tag="C1A50_RS23605"
                     /old_locus_tag="C1A50_5031"
     CDS             complement(23378..24337)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013373632.1"
                     /locus_tag="C1A50_RS23605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5031"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_017426155.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.6e-07, bitscore:
                     28.8, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 6.2e-12, bitscore:
                     43.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEDMSLQQLQSYMGSNPKPQDFDMYWERALQELERQPLEYTLEP
                     AEFVSPLVECYHLYFTGVGGARVHGKLARPKHLTEQGPALAMFHGYSCDSGDWFDKVSY
                     AAHGFTVLAMDCRGQGGLSEDNLQVQGTTVRGHIIRGIDDPDPDRLYYRNVFLDTVQTV
                     RILMSMEQVDPERIGAFGCSQGGALTVACAALEPRVRVAVPVYPFLSDYKRAWALDATT
                     SAYEELVYYFRWFDPNHVRESEVFHRLGYIDIQHLADRIRGRVLFVTGLSDVICPPSTQ
                     FAVYNKIVSDKELLVYHEYGHEYLPYLSDRAMSEFLRL"
     gene            complement(24350..25399)
                     /locus_tag="C1A50_RS23610"
                     /old_locus_tag="C1A50_5032"
     CDS             complement(24350..25399)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016822703.1"
                     /locus_tag="C1A50_RS23610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5032"
                     /product="glycoside hydrolase family 130 protein"
                     /protein_id="WP_045244715.1"
                     /transl_table=11
                     /translation="MSKLNVDLDVGNVRIVGDSLSKMPWQDKPEGSEAPVWRHTENPVI
                     GRNPVPGIARIFNSAVAPYEGRFVGIFRAETINGRPHLHLGWSDDGLAWDIETERLHMV
                     DEEGNEYQPNYAYDPRLVRVEDTYYIIWCTDFYGAALGIAQTKDFKSFVRLENPFLPFN
                     RNGVLLPRKLNGNFMLLSRPSDSGHTPFGDIFLSESPDLVYWGKHRHVMSKGGQGWWQS
                     VKIGGGPAPIETTEGWLMFYHGVTGTCNGLVYSMGVAVLDLDDPSKVKYRSSNFVLTPE
                     EWYEERGFVPNVVFPCATLHDADTGRIAIYYGAADTYVGIAYTTVSDIIKYVIATDEVV
                     ADDRESGRM"
     gene            complement(25442..26275)
                     /locus_tag="C1A50_RS23615"
                     /old_locus_tag="C1A50_5033"
     CDS             complement(25442..26275)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013373634.1"
                     /locus_tag="C1A50_RS23615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1A50_5033"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_016822702.1"
                     /transl_table=11
                     /translation="MYKLKRLLANTIKYGALLLGAFIALLPIVVILFASLKTKAEYAAT
                     SPLTPPVNWLNWANYAKAFVDGNMLTGFLNTAFILLISIIGATLTGSMIAYILNRFKFK
                     GKSLMLGAFLLATLIPGVTTQVSTFQIINKLELFNTPWAAILLYLGTDIIAVYIFLQFL
                     DSIAVALDESAMLDGASYLTIYWRIILPLLKPAIVTVIIIKGVNIYNDFYTPFLYMPKT
                     SLQVISTALFKFKGPYGSQWEVISAGIIIAIIPTLVAFLSLQKYIYNGFAQGSVK"
ORIGIN
        1 gaattggaat cttttttgct cagcgccagc acgaattagt ctgggctcat tccccgcata
       61 accttcaccg ctacgagcgc aagctcaaca aggacgcatc caagtcagcc ttaacttcca
      121 atagcccgta ttcacatttg tgtgacctga gcagcatgcg catactcagg tcacacaaag
      181 gaatacgggc tatttttata atatgtggca tggtgctcat ctacagcgtt ttgacagatt
      241 ctcctcgatt gatatccggc acaaatcggt aaataatcgg aaccgactcg ccgccttcct
      301 caatgctgga caacaacgtt tttgccgcct gtttccccat atccgcaatc ggttgtgtaa
      361 tggtcgtaat tggcggattg taaatatgag caaactccgc atcgtcaatc ccgataatgg
      421 acagctctgc cggaatgcgt atacggcgag cattcacata cttcaacacc tcagccaaca
      481 cgatatcatt cccggccaac agtgcagtcg gcggctccgg cagttggaac agctccttca
      541 gcgtctgctg gatttcttct ctcggcacgc tgtgcatata ttcttcacga aatggcaagc
      601 catgctcctc cagcgccttc ttatatccgc tgagccgctc cactcgtgga gtaatccgat
      661 tcaagccaag aggcaaggta atcaacgcaa ttcgttcatg cttgtgagcc acaagttcct
      721 gaatcgccag cttaatcgcc atttcgttat ccaacagcag gctacgtgta ttgacaccgt
      781 ccaccaagcg gtccaaaaac accaatggat atttttcacg aatgagctgg ttgtaaatgt
      841 ctgcatgctt tcctgttggg aagatgatta ggccgtccac ttgacgggcc ttgagcatct
      901 caatatactg actttccttg tcagggtttt catcggcgtt gcaaatgatc acctgaatgc
      961 caaagcgctg caattcctcc tcaatcgcac ggatagactg aatcgacagc gtataatcaa
     1021 tgttggctac aatgactccc accataaacg tccggttttg cttcaggctg cgggctagtc
     1081 cgttaggctg atagttcagc tcttgaataa cctcggcgat ccggtctttg gtttggtcgc
     1141 tcatatattt atatcgtttg ttcagaaatt gcgagacagt gcttttagac actcccgcct
     1201 tctgggcaac atcttcaatc gtcggcttct tcatcggtac actccttgtc tttcatgtac
     1261 tgcgttagtg caacaaaagt atatctttct tttagtaaat ttaccatact tctatttatg
     1321 aatgccatta tgatatattc tgagcttaaa acttacctgt ggcgccactg cgcgtttttt
     1381 tcataacagt tcctggttct ctgctatttc ctctctatgc agcaaaaaga ggcagctcaa
     1441 gatgttctct tgaactacct ccacgtatac aactctatcg aaaagctaga ttctagctaa
     1501 cccgaattat tacttggatt agtgcgccgg aacaggcgtt gcaggctgat ctggtgtatc
     1561 gtgctcgacc agcgaatgct tctcccataa ccggcttctc cagcgggcat acatgatgac
     1621 agcacgagtc cattcatcag cagcaatcgc cagccacaca ccagccagtc ccatatccag
     1681 cttgaatacc agcagataac ccagcggcaa gctcatgcag accatggaga tcagacccat
     1741 aaagaccggg aacttggcat ctccagcagc acgcaacgag ttaataatga cgatattcgt
     1801 cgtccggcca gtttccagca gaatgctaag taaaataacc tgtgcaccca aacgaataat
     1861 ctcagggttt tccgtaaaca aaccgagcag gggtacacgg aaaaagataa ctatcgcatc
     1921 aatgatcaca gtcacgagca gcgcccattt cacactgctc aatacacgtt tataagccgt
     1981 atccttctct ctggctccca cgagtcttcc cactacgata gctgttccca taccaactgc
     2041 catactgaac aaataaatat agctcgaaat attattggca tattgacgtg tcgccattgc
     2101 ttctgcgccc agataggtca cgtacagtgt gaatatgagc tgacacgact gatacatgat
     2161 ggactccagc gcggatggta caccaatacg caatattttt gagataaatt ttttggataa
     2221 atggacgtaa tatttccact cgacacggac ctcagttacc cggtacatca gccagaagaa
     2281 gatcaagaga caaataaagc ggctacctac tgtagaaata gcagcaccct ctacaccgag
     2341 tgcaggcatt ccccaatgtc ccaaaatcaa aacatagttg ccgaccacgt ggatcacgtt
     2401 cataaaaacc gatacataca tcgtttcttt ggtaaaaccg tgcgtacgaa tggtcgccgc
     2461 cagcgagtta atcaatgcct gaaggaaaat ggcccccccg acgatactca tataggattc
     2521 cgcgtaagtc agaatatcac cctggacatt cagccattgc aacatatgag taccaaacac
     2581 aagaaaaatg acgcttagca aaagacctac cattaaattc agagtaatgg ccgtacccgt
     2641 cacctgggcc gcttcgacta gtttcttaga accgatatat tgagctacga cgatagcagc
     2701 gccgttgccg ataacctcca gtacaaggat agcgattgaa ataatttgat tggatgcgcc
     2761 cacacccgac actgcattat cagatacaga gctgagcatg aatgtatcga cgcttcccat
     2821 tagcataaac aggaacaatt caaggaaaat aggccatgtc aaacggaaca aattcagttc
     2881 cttggcttcg gacaataccg aaccattttt tagtgctctg gttgtcattc attcaccttt
     2941 cttcatagaa tatttaacga tcaaagggta tgttagcaca gtcattctga aaatacatcc
     3001 cgtttacgta aaatgatttg aaaaatgcgt aagaattcat ttatcactct ctttataatt
     3061 gattatcgaa ctttattgaa atagattgtt gcaagaatat atccataatc cggtattttc
     3121 gacgtaattc taagctaaag ggtataatag attaagagct tgtgagcatt gccgctgaca
     3181 ggctgtgcag attgttgtat gctgcataag cataatttgt atattagaga tggaatatat
     3241 agaccattca taagcttaaa cggtaataaa ggaggctttt acagatgact cagtcatttc
     3301 atgcccttgt cgtcgatcag acgcaggacg gtgaagttca agcagaggtt cgttctttgg
     3361 aaactggcag tttacctgct ggagaggtat tgattcgtgt cgcttattcc agtatcaact
     3421 ataaagacgg gcttgccgcc cgcaaggatg gcaatattgt caaagcctat ccattcgtac
     3481 ccggcataga ttgctcggga actgtcgtct cctcggagga tagccgcttt agcgagggac
     3541 aagcggtact cgttacaggc tacgggctgg gtgtgtctca attcggagga ttcagccaat
     3601 acgcgcgtgt gcctgcggac tgggtagttc cgcttccaga cggactcacg ctgagagagg
     3661 cgatgatttt cgggacagcc ggatttaccg cagccctgtc gttatatcgg ctagagcaaa
     3721 acggcgttgc accggagaag ggcaaggtac tcgtcaccgg agcaacgggt ggcgtaggcg
     3781 gtgcagccat tgccttgctg cacaagaggg gctaccatgt cgtagccagc agtggcaaag
     3841 ccgaatcgca tgattacctc aagacgctcg gagcagccga ggttatttcg cgtgaggagg
     3901 tctacgacgg tgccgagagc atccgaccgc taggcaagca gctttggcaa gcggctgtag
     3961 accctgtagg cggaaagccg ctcgcttcgc tgcttagcca gatcgcctac aacggctctg
     4021 ttgccgtgag cggcctgaca gcaggcacca agctgcctac gacggtgctg ccgtttattt
     4081 tgcgcggtgt aaatctgcta ggcatagact ctgtcttttg cccctatgac acccgcgtag
     4141 cgatctggaa gcagctcagc agtgactgga agccggagca gctggagcag ctcgttgagc
     4201 gcgaaattgg cttggctgac ctgccaagcg cgctcgaaga catcctggca gcccgctcac
     4261 agggtagaac gattgtacgg ctagctgatt aagcgggatt atgcccgcaa gctatccgtt
     4321 agcgtgtttt tgccccgaag gagtgctcat cccgtagggg ctagcaatga aacatataag
     4381 aagcctgtaa atctgcagtt ttgagattta caggcttctt tttttgtgtg gtacattgga
     4441 gaaaaagtgg acacattcga agcggacgat ctatttttca caaccaaatg aaccttttga
     4501 ggactccagt tgttatatag gtaaactgca cgagaaagga gagccatcat tgcaaagtaa
     4561 tcgagagttg tttgatctat atcaacggga tgtataccga acctgctatt acatggtcca
     4621 taatgcctcg gatgcagagg atttaacgca ggaagtgttt attactctgt ttcacagcaa
     4681 tcgcgagcat atcgagcaac taaaagcctg gatcatgaaa gttacggtca atcattgtct
     4741 gaaccatctt aaacgccgaa aaagcctgca tttaaaggta gcggctaatc cccatctctt
     4801 tactggaaca gaaggcaagc ctgtggacag gcaggtggag gaacgcgagt cggctgagga
     4861 atgggccatt tacatgaacc gccttccggc caaaatccgt gctgtgctga cacttcgcta
     4921 tatgcatgat ttcacgctag cggaaatatc gaaactgctg gaaatcccgc tgggaaccgt
     4981 caaatccagg acacacaaag gactaaagtt aatggagcaa atactgcggg gggctgatgc
     5041 acagattccc aagctggaag gagagaacta tgaacaacgt agaaaaggca ttgaagcgca
     5101 agttaaatga agattcggaa ttggcgcatc ctaacttcga tgagatgtgg aatcggatgg
     5161 aacaggcagg ccatactgcc cttacgccaa ccggcgtttc ggattcattc actccacacc
     5221 aacatagaaa ttggcgcaaa atagccatcg ctgcctccct gagcgcactt ctcgttgccg
     5281 ttcccgtcta tgctgccatt cattataatt ggggcaatct gctgcacgga agaagtggaa
     5341 ttgagacagc attagctcaa gacctgggac agccattaga acagtctgtc accaaagacg
     5401 gaataaagct gacgttgcat accgctattg tcgatgagaa ccggactgta attctgtaca
     5461 gcctggaggt tggaaaacgc gcagacaacg agttttggaa tgtcaaaggg gtatcgctta
     5521 aaaatgctgt gggaaaaagt agtgaagggg agtatagctt ccaacaatgg gatgagaaaa
     5581 accaacgcta taacggctac tttgaaagcg attggacacc gcagcaagaa acagaaaacg
     5641 tgcggctgac cgtggatcat attgagctta ccagcgttca ggaattggat ttgccgctcg
     5701 atatcacatc gcctcagaaa cagactttca ggctagatcg taacggtcta caagatatga
     5761 aggtacaggt attcgaacaa ggtaaggaca agctgatgct gtcatcagca attaccttcg
     5821 attcctccat accaaaagaa tgggacaatc cgcaaattat tgcctacaaa gatgggaagc
     5881 ctgtgaaccc ccaatctgga gggacatttg gtacacccgg tgaggacgga gaatacacag
     5941 cccagcagta ttttactaaa ggggatatac cagaagggca gactactttt aaactgcaat
     6001 atgcacaaac ggagaaaagt atacatgaac ccctaaactt tgacctgcag ctaagcaaga
     6061 agaaaatgga gagcgggacg attaaaagtg tgctgaatac ccccttggag aacggtaatc
     6121 cgaatttcat gctggaacaa atgattgtca caccgacaca aatccgtgtc acgatcagaa
     6181 gcgaaaagaa attcgccatg ttgccttatc aaaaatattt tctttctgtg aacggcacaa
     6241 cgttagaggg taatcgttgg tcttcaccag atcaggacca cgatctgaat acgatccgtt
     6301 ttgaacggcc ggcccatctt gcgattaccc gagatactcc cattactttt acaggcaaat
     6361 acaaggttac gactcattcg gatgacaaaa cgccgcagca tttgactgat atttctgagc
     6421 aaaagcagac gataacgacg caaatcggcg gctatcctgt gaagtggacc tactacaaac
     6481 aaggagcaga tttattcgta gaaaccgaaa gtgaggatac tcactttgga gggatcaacc
     6541 agacgcatat tggtctgggg aaagaacgga tgattggcaa gccgatcaca gccaacttcg
     6601 ccggagacgg caataataag gcagtcgatg tctacaagaa cttcaaggga aaggaagctt
     6661 ctatttatat gttctactat acaacggacg aacctgaagc agagacgagc gtacccttgc
     6721 agccactgac tagcaacagc caagcatcta aataaccatg ctataaaagg agggttctct
     6781 atacctgtgt gattcacagt ataggaaccc cctttttatt cgcctagtaa ggcacagcct
     6841 gctgcttgaa gctgttgtat tctcatctta ttttacagaa ccttgcgtaa caccattaat
     6901 aatccatttt tgtgcaatca gatagacaat aatcatcggc agcaaggcca tcaagtacga
     6961 ggcaaaggcc agattaaagt cagtattgaa ctgtccctgg aacacatact ggacgagcgg
     7021 caatgtatat tgctccgcat cgctgataat aatgagcggc agcaaaaagt cattatatgt
     7081 ggacaaacaa gtgagaatcc ccactgtagc actaatcggc gccatcagcg gaaatataat
     7141 acgccaaaat gtcccccatg tcgtcgcacc atctaccgtg gctgcctctt ccaatgccac
     7201 tggaatcgac cgaatataac cgacatacac gaagacatta aacgccaagc catacaccgt
     7261 atgcagcaca atgaggccca acagattggt catatgtagc cccgaggcca gctttacaat
     7321 cggcagcatg atgatcggga acggaataaa catggcgctg acaaagtaaa aatataatcc
     7381 tttgaaaaaa cgccgctgca tattgcgagc aatggcataa gcaaccatcg agttggtgag
     7441 caaagtgagt atgaccgtcg atgttgtcac catcacacta ttctgaaaag cactgaaaaa
     7501 atgggtcatt tccactgcac gactaaaatt ttcccaatgc agctccgtcg gaaaggcaaa
     7561 ggcggaatgc gccatctgct cgggattttt gagtgcaatc gtcaccgtca tatagagggg
     7621 aaacaggata aatattgtcc ccaacgctac cagaatcagc acaggccagt tggtacgtct
     7681 gcttgttttc atcagttatc catctccctt ctttggagga atcgcagctg taagatggaa
     7741 atgatcgcga tcacaataaa gtaaatcaca gagttagctg actgataggc aaattctcct
     7801 cctctaaagc ctccggtgta tatcagatga gaaatcgact gcgtggcccg tcccggtccg
     7861 ccgttcgtca aggccacgat ctgatcgaat accattaggg aatttttcat cgccaatacc
     7921 atattgatcg taaaaaatgg agcaatcaac ggaaaggtaa tgctccagaa ttcacgccat
     7981 ttacctgcac cgtccaggtt ggatgcctca tacagactgg tcggaattgt ttgcagccct
     8041 gccagataga ggatcgtatt aaaggcaatg ccctgccata cggctacaat gaccaccccc
     8101 acccaagcca actgctcgct acccaagatg ttagtcgata gtgaactgat gcccagattt
     8161 tgtccccaaa tcgtaaacac gttcgagaac aggtaattaa atatgtaacc tacaattaat
     8221 acgctcaaaa tattaggcaa aaaataaatt cctcgaaaga aattacggaa acgtatttta
     8281 gcgttcagcc ccatggcaat caacaagctg agaatattaa tcgcaatggt aaccacaatc
     8341 gcaaatttga aagtaaacca gtaagcattg cccacattgt cgtcctgaaa caaattaata
     8401 tagttcttaa atccgacaaa gtgatactga tgcccgaatc cgttccaatt ggtaagcgaa
     8461 taataaaaac cctgcaaggc aggtaaggtc aaaaatacaa aaaacaatag caccgccggc
     8521 accgtcatcc agtaaaaagt cgtcagtcgc ttattcatgt ctcatcctcc tcccctatcg
     8581 gcggttagct accttattcc actcacggtc gagcttggct agataggcgt cgatatctcc
     8641 attttgcagg aaagcctgca caatagaatt caattggact gctttgggaa tataatgatc
     8701 ggcaaaatca atgacacggc ctgatttaaa atacggcaac aactctgcca cactcgggtc
     8761 atcctgtgtg actcccttca ccgctgaaaa caacgtttgt tccgtaatgt attgcttgct
     8821 gttctctggc ttcaatagga aggcaatgaa ctcttcagct tcctttttat gcggggtgct
     8881 ttccgaaaca gctaatagcg tatctattcc agacactagc ttgaccgcct ttgcgtcatt
     8941 ccctgtaggg aacgggaaaa atccgagttc cactttcggg ttggctttgc gaatttcaga
     9001 tatagcccac gagccctgaa tgtacatcag tccctgcccg ttagcgaaag cacggttccc
     9061 gtcagcatag tttttgccga agttatcact atgtccgtat ttcagcagct ccagctgctt
     9121 ttccgcaacc tcgcggtact tgtcctgaaa ggtgacctga ttctcacgcc gttgcaggaa
     9181 aaaatcaata cccaccaggt tcggacccag tgcgttaaaa ggaaggttcg tttgccaatc
     9241 atctttatat gtaaaataga atgggatctt gccagcagcc ttgatttttt gcgctgttgc
     9301 aatcagttca tcccacgttt tgggcacctg taatcccatt tccctaaaaa gctttttgtt
     9361 gtacatcaca ccattcgcat tcgcagcata aggaattcca tacacaggat cgaccccggt
     9421 cacatcctta agcattttga ggtaaatcgg gtccaccgta cgtggtaatt ctgtatttgc
     9481 cagatccgta aaaataccgc tttgcgccaa aatggagtag gtatctgtgg ccccaagccc
     9541 cacaatgtca ggtacatcgt ttttgacaac ccgtgtcaat agcaccgttt ctgcctctgg
     9601 cgggttgacc tgtgtcactt caataccagg atgctcctga ttgaattgag cgatcagctt
     9661 atcgaatgaa cccttagcct ccggcttatt ttggaaaaac tcaatttgca ccttgcctga
     9721 agcgtcgccc ttattgcatg cgcttacaac gatcgttagc agcaggatcg ccgctagtgc
     9781 agacagcctt ttgaccccat tccacatgct catacctcct tttcccctat gtcaatctat
     9841 gcggtactag acaattaata cccgtccctc gcagaaaaga aacgatacac cgtatttcta
     9901 ccctaaacgt ccgtataaaa aagacccagc taacctcgaa tggtcgcttg gatcttttct
     9961 atttgtatag tgtcaggtta ggcaaaaaaa tttctatatc ttagcgaatt agaaaagcag
    10021 catcccagtc cggattctga tctccaatta aggaggctaa caccaaagca actccagcac
    10081 ttccattcaa aaaaccagcc tcatcaactt ccgctaacct tccatccagt aagctatgat
    10141 catagaagcc aaacaacgaa ttagcatcga acatatctaa tacatcttca agtagtctgt
    10201 cccggatcct ccctaactgc tcatgggaag tatctgagta catacgttgg actagatgca
    10261 acaatccccc aatcccatga cataatgtag cagaagataa tccccctttt cgatggaggc
    10321 gtttctctat atctaaataa gcggaaagcc ccgtttcgag ccattcttca ttgtgaacag
    10381 cttgtcctgc tagccagata gaacgtgcga tacctggtac accatagcac caagaatcac
    10441 gatagtttcg agtgcttcct gataaaagct ggccatccag ccactcccca aaggaaattc
    10501 gaccaggcca aattatgccc tctacgtcct gaacacgcca atgatgtata aactttccca
    10561 gtctatgtat atcgttcatt aaaggggagg cgtccactcc atgaagggca gacaagctca
    10621 gaaaacataa gggacctgca ataccatgcg aaatacctaa attaaaattc ccctgaggat
    10681 actgtagctt ttcatcctcc tgaaactgat gttccgagga aatgtgccaa gcgggtacag
    10741 tgtgaccatt tagatttttc tcaccgcaca tgacgtggaa caaatccatt gtctgttccc
    10801 ataccatctg catgcccggg cggttcagga acagcatagc tatacgccca actcccgcaa
    10861 agccagagat ggtgtcatat tgactcatcc gcagctctcc cttttcccac tcaatccgat
    10921 gtagagccag actttgtaaa gcagcttctt caaaccatga agcaagtgca tctagcatac
    10981 cttgataacg tgtacccttc ctagataaag agtaaatggc cagcataata cctgccaatc
    11041 cactatacaa ggataaatcg tgaacacctt tttgctctac caccatacgg attcgctcta
    11101 aatattgatg tcctacaata tcccaaccat ttttgggata aagataatcc agctgaccca
    11161 tgagcaaaca tattcccgta aacccactac ccaagctttc atctgcccaa cgttccatta
    11221 tcaccccgtc ggcttctatt ggaggtatct ttttcatcca taaacgcacc tgatccgggt
    11281 ttctataacg ttcggtaatc tcccgcaata atgtagatat cttgttcttc atttccccct
    11341 tgacgggtat ccagttatcg catgtatatg aaatcgtcgt catcctatac tctccctccg
    11401 gtttcggcca aagcttcctc gtcattgaat gaactagctt gaatgttgta catctctgca
    11461 tataatccat ccagtagcat cagttcccga tgggttccct gctcgacaat tcccccatta
    11521 tccatgacca caattttatc cgccaggcgt gccgaagaaa ttcgatgtgt tataaagatt
    11581 ccgatgctat ccttcattaa ctctagaaat aacttcagca aatccctttc tgctactgga
    11641 tccaagaagg aactcggctc atctaaaata tatatatctg cctggcgcaa aaaagcccga
    11701 gcaattgcga ttctctgcca ttgtcctccc gagagctgga agccatcctc gaaccatttt
    11761 ccgagttgtg tgtctaatcc ttgcggaagc tcggttataa tctgatctat agctgcatat
    11821 cgagccgctt ggatgagctc ttcatccttt tccaaacgtt ctagcgaccc aaagccgata
    11881 ttatgacgtg ctgacatttc ataatgcata aagtcctgga acacaactcc gattttgtcc
    11941 tgaacttgat gcagatcata atcctgaacg ggaagaccgt taatcttaaa cacaccttca
    12001 taattggagt aaagctgcat cagtactttc attagcgttg atttacctga accgttcttt
    12061 cctacaatag ctatagtttg gcctctattc acggttaagt gaatatcacg tatagagggg
    12121 actgttttac ccgaataagt aaaagaaaca ccttctatac atatttgctc aatacaaaaa
    12181 tcttcatttt tttttcggtt aatcggtagc gcttgttcct tttgctgtcg gaccggatct
    12241 gatgtgggaa gctgtaaaaa taaaaacaac tgttccatat acaaattatt ttgcgagaat
    12301 tgaacaattc cctgaatcaa tgcctgcatc tggctttgcg tcagcataat tgcttggata
    12361 tagccatata agctacctac tagtattttt ttctcaaagg tctccctaat agccacccat
    12421 actactccta acaacacagc aagctccagc agactgtaca taaaagtgat tgtgaccctt
    12481 ttccccagaa ttcgtcggtc ctctacaaaa aatctttgta gcaaatcctc gtatctctta
    12541 agcaaataag aactcatatt aaaaattttg acctccttga ctgcacgatc attggtcaac
    12601 aagtaggtca tataccaaga ctctcgatat aatggagttc gattcatata gatttcaaat
    12661 tgttctttgt ttagcttaaa aatagagtat acagatacca gagagatccc aaacagaatg
    12721 ataactaccc accatttcca cagaagaatc aaggttgcgg aagagaccat ggtaaccata
    12781 ctggataaaa ttcctgccat ttgtgtatac agttgatacg gtcgataaga ggcctcctga
    12841 gaggcccgct ttaattggtc atttatttct gaattctcat aatcagctaa tcccaaagag
    12901 cttgattttt tcccgatcat taagttcaga gacttagaca gcactgattc cagcgtacct
    12961 tcaacaaacg tttggctcat tgtaactaca cttttcagta cgtgaatcac tataaatatg
    13021 ccaaactgta acataatcaa ggagatgcct tgagtgccga aggaaacaat gctgtttaaa
    13081 aggttttgca taattattag tgtcaggact ggcattaagc cctgaagaat atgcaagaaa
    13141 atgcttgata ccatgtacgt cttattcata ccaaatacca acgaaaacaa ctttaacccc
    13201 tgtcgcaccg acctccagat agtggaagac tctagattca ttttcgcttg aatatcggtc
    13261 attgtcgatt cccccgatat tgaactaaac tgttcagagc atgtctggcc ataatcatga
    13321 tcttccgttc tcgatccctg tctatcccta gcagtcgatt cagatgcata tgaattacac
    13381 taaatacgat atcttctctt gtgttagtgg ataatccccc cgtttcatgc tcatagagta
    13441 catggctata ctgctttacg gcttctcttc ttatcttgaa aatactctct atagcttgga
    13501 gattggattg aatggattgt gaaatttcct gatcggatgc aaaccattgt aaaaaaaact
    13561 tccgttcttt gcggaaattc tccagatatt ccttaacatc aaaatatcga ttcagtaagt
    13621 tgaacgcatc tttctcatgg taaccaaatt gatagagaag attgataaca cttaaggtgg
    13681 ctataatatc ttcttctaag gaaacttggt taaaccggat gaggtgtaca agcttagctg
    13741 ttacctcact atcgcacgaa aacattctct ccgcccaggc catgggttta cttccaccat
    13801 atcgctctat ctcaggctca tatgtatcga tgaccaccct ggctatcatc ccttcatgca
    13861 gcagcatttc tgtccattta tgaaacgtag agagaaatcc atctgctgtc ctattttttg
    13921 aaagctcaaa tcggacacgt agatgcttgt ccggatcggc atatcggata aaatatgcct
    13981 gaaggatagt accgttgtct tgatgcttcc gcacaaattc ttcccaatat ccacctataa
    14041 actcattttg tcggctattt ataccgtaaa gcttcgcgta gaaccaagat tctcccggca
    14101 ggtaagtata gtctgccttt gttggttgtt gctcattttc ttttgcaacc aattcaagag
    14161 aagctgcagt ctcttccaca aaatgttgcg tatcttcagc ttgatttcga acgagaggac
    14221 atacaaattc agcagttaaa tgtccttttc cacaggagac tggtgaattg tcaaggccgc
    14281 caatgtgctc tatcaaggta accttacctt tagactgaag gtccctgcat atttgttcga
    14341 tatgcaacgg atgatccata tctagtaaaa tacgattatc cgattcaatc atataaacat
    14401 aacgtggtat gttccacttc tcttgaaata aacgtatctc ttcggcgaag tctgccatct
    14461 tcttcgatga gctacttgca attctccatg ttcccgggta gagaatgata tgcttgtacc
    14521 tgagacgtgg ggtaaaaggg gcgtgagcca caaatcccca ctccataggc gaccaatggc
    14581 ggtaactatt atcgctaacc tccacgagaa aacggtatat attaggcgtc aactctgcat
    14641 taagcatgtg tcccgaacta gcaataacct ctcgattgcg gctttttgat ttcaaataaa
    14701 agtgatcgtt ccgcacacca acgactagat cggaaatatg aatttgtcga tcttccggca
    14761 ttgtatgatt agcccctatt gcgatctcat aaggtcgagt ttgtttcgtc aacacgacat
    14821 tagctgatct tcccgagcta ggcaagtaag atatcccagc aagcagcttt ccaggttgca
    14881 aacgctgctc ttccgactgg atactagaaa atatatcgtt aaaaggctcc ccgaacaggt
    14941 ccataaacct accgaatgtc tttcctgctg catcagaccc ctgattaggt gctaagagca
    15001 acgtatattc accttgatcc aaagcctcct gatcagaagt aattagctga aaaaataatt
    15061 ccatggaggg tgcagctagc catttctccg tatcgtgacc ctttatcaat tcatcgatca
    15121 tgttatctgt caatacaatt tcatgctttc cttcatgcat agcagataca aaccattgaa
    15181 acaaaagctt ttcttgatgt gacctcgact tggatggaga catgtcctgt aaccgtactc
    15241 gacgactcat agggtgttta tagcctgccg gggcccctag ccctgtgtcc tcatcaagca
    15301 gatccagcaa aggtacctcc cgatatggtc cgtatttctc caaaaattcc acacaaaact
    15361 cattcaaagg tctgttttca cgcgttgaaa gtttggtcaa taattcggca acacactcaa
    15421 tatccttacg aatggattgt ggaaggatga tacctctatc ttccagggag agatcgattt
    15481 gcaaacttga ttttgcacta aacattttgt tcattttttg tcttaagctc tctaacagtt
    15541 gttctccttg acctatagga agatgattat atttagcaga agtatctgcg attgtatcaa
    15601 gatcttcttt taactcttcg atacctgtta ctggtttcag aacagaccgt atataactta
    15661 acggttcagt agtcgtcgta ggtgggataa gttcagaaat cagaaactct tgttcgaaaa
    15721 gttgccacac gtaacgttca attacctcaa tattagcact ctcaaaagtt ttattaagat
    15781 gatcgaccaa atccaaaaat ggtatgaagg ctgaactcgc agccattaca cagtcaaata
    15841 cttgagttat acgaacagac acactctgat cttcgccatc gttcatactg ccatgtcttg
    15901 tcgtataagg aattttggca cggttaccct ggcgataaat taatttatta ctccgaaccc
    15961 gcagttggcg cacaatctcc tttcgacttt caaccagctc aaccgctttc attagccatt
    16021 ccatatcagg tctcgcacgc tttttaaacg tgtctgttcc ttgcaaaaat agctgcgatc
    16081 gttccccaaa tcgcccatat gtgataccag atagtaagcc aaacggcgtt ggccgtgtaa
    16141 tcattctaat gatataacgc ataaaagctt tgattacttg tccttgtttg cgcggattct
    16201 catgattact gatatgtacc aaagattcaa gcaaagtggg actggaggcg gctagagctt
    16261 cacgaatgaa cggatcacgg gacaattcca ataaacgctc taatgcaatc tctctagcgt
    16321 ccccccctct ttaatactgc tcggaaagca tttagaaaac tcttgaatgg gtaatacagg
    16381 agtacgaagc atgaaaaaat ctaacgtttt gtacagattt cctgttgtct tcataaggaa
    16441 cctccgttct aaaacaaact tttaaattat tttcttttgc caacgtacaa agctgataac
    16501 tgagccgacc aaaataattg cgattaagca catccaaaac ttaaaggaac cttccaccct
    16561 taaagcaagc ataatttgtt gaaagggatc catgagtaag acaagcggtc taaccacctg
    16621 ataaagagcg acagataaaa caaaaattgc gataaaagca aacaaaggtc ttgaaataaa
    16681 caagcagaca gcactaacta acagcaactt tgccacgcag gccagtgtta aaatcaaata
    16741 gaatgcaagc gtatatggga ttgcatccga tgagggagat attactcctg aaccatattt
    16801 aaaaaaggta gaggtatggg gaaacagtaa ccatccagcc actatgccta tcaccaaagc
    16861 cgtacctgta aatatggcgg ttgtaacaga taaagcgagc agcttgccaa gccagaattg
    16921 aaaacgacga tatggtcgca atacatatag ccgatatgct ccgctatgaa gatcgccgcc
    16981 taattgatcg acatacagta taggcaacat ggctaagatt aaaaaaagag aaatttcgct
    17041 catcataagc catggcagat ttaaattatt aacaactaca gttccctcac caaatcgaaa
    17101 tcgcattgta ccatttgttt taagactcca tatattcaca aaaatgataa ggagcattgc
    17161 tatatataat aaaaaagtag atttccgatt ccaaattctc tctaattcgc tcaaccaaat
    17221 tccagacata aatagatcct cctaatacaa ataatcatcc gttgtaaagc ggcggtatgc
    17281 ccaccctgta aaaagaatca gatggaacaa gacggcaatc acaattgccc cattgacgga
    17341 ccaattccat atcagtgatt gatctagtcc cttgtattgt aaatatggaa ttaataaaaa
    17401 tggaatcaga ttctttaaga gtggaataga agagaataaa gtagccaatt tcatgtacaa
    17461 cggatcaaat aacaaaacac ccagattata ggtcatacaa ataccaattg catatgttac
    17521 acttttactg cacatagcaa taaaagaata gagtgaactg atagctaata aagaagcaaa
    17581 tgcccaccca taatattcaa acacttggga ccatatttgc ccgaaaatat ctgtaccgtt
    17641 tatattatgc gagaacttcc aaaaaacaac aattacttgc gaggatacgg cgtatacaat
    17701 cagaagaagt aaaatagaag tattaactac caataattta ctccaaaaga tctgaccacg
    17761 ggtaaaacga cgcacaaata acaacctcag ctgtccgctc ctaaactcct ccgtaaaaac
    17821 agcagccacc agggtagcca cagcaaaatt acatattaaa tatagatttt cacgcaagcc
    17881 tgcaacaata aaaattttag ataagtcctt cacaggaatc cttaacgtat gctgtatgta
    17941 tatccccgtc gaatatacaa gtacaggggt gcataaaacc aataaccaaa accatttcct
    18001 tctccataat ctctcaaatt cactataaac aagtgttttc atagccccat cagccccata
    18061 aaggcatcct ctaaccgttg gccatctttg ataagttgat cagcggcccc cttccaaata
    18121 agcgttcctt ccttaatgac aatcaactca tcacacattt gctgtaattc atccaacaga
    18181 tggctggaga caaaaaaagc ataattatct gaatcacgca aacgaagaat tatatccctc
    18241 aactcacgca tccccatggg atcgagacca ttggaaggct catcaagcaa caatagctcg
    18301 gggttaccca acatagattg ggctatacca agccgttgct tcatccctag cgagtaggtt
    18361 ttgaccttat catccccgcg attttccaga ccaacccgtt ccaacaattc tttaatatgt
    18421 ttttctcgat ccgaagatgc aacacctaag tgcaatcggg acaaattacg cagcacctgt
    18481 ctgcctgtca tataatcaaa aaagaccgga gactcaatga tagcgcctac tttggataac
    18541 gctttttccc gatctgtctg tatattatat gaagctatct ttacagaacc actagtaggc
    18601 tgcatcagtc ccgtcatgat tcgcatcatc gtcgtttttc cagctccatt cgggccaatg
    18661 aatccatata ttttcccttt ttcgagctca aatgaaatgt tatttaacaa acttcgttta
    18721 cctacagttt tgcttacctg ctttacttcc aataagaaat cggtcatacc ttttccctcc
    18781 atcaccaaac acgatatcaa aaatatctct aaatattata tagttaaaaa ataaatattt
    18841 atcaaacaag aagaagggac tttaaggtcc ctccttcttg tttttctttt atggagtaca
    18901 aaaaaatcca ttatctaaaa aaagcaacaa tcgagattag cagagtgaac caacgttagt
    18961 aaagcaccgg ttgccacaag tttcaacaca actggcagct gttttaccgc taccacatcc
    19021 gctagaacat gccacaatgc tcagaacctg aggctctaca gaaccttgag atttgtttac
    19081 ttgaatgtcc agatcaaata agttttcagc cattgcattc ccccctttca tttagatata
    19141 ccctcagctt tcaacgagac tcatatctat cccgccgaaa tgtcttccct ctttagtaga
    19201 aaagaaggat ttatatgaac aacatcccgc ccagatcgtc atccatacga aatattgtca
    19261 tatatgaaca tgtggaaaac cctatgtata attctagatg acaatataaa attcatttaa
    19321 cagcgattag cctcgccctt acaagtgaaa taatatcaca tgttgcaaaa tgtaaatcta
    19381 ttactttata tgtaaacata cataataaaa aaacattata attcattaat ttaaatatat
    19441 ggttattctt ttcccactct ctcattctct ttaccataca aaaatagccc ctcggcagac
    19501 gcgctacctc agggctattc tttatgcaaa tatacgttgc ctacttcaac aaccagcctg
    19561 tcgcctactc cagttcaacc cactcgccga gcaacgtgtc cagctccgct tgcagtcgct
    19621 cacgcacgtc ccacagctcc gccatgcgcg ctgtgtcgct gcttgtgccg agcagttcca
    19681 gctcggcatc tgtcgccgcc aatgctgctt ccttggcggc aatcgcccgc tccaaccgct
    19741 cgcgggacac agcgggtgag cgggatggct tcgcggcctt cgctccgcgt gccccactcc
    19801 gggcatcgga cgcccccaag cgacctgccg ccccggagcg agcacggctc gcatcggctc
    19861 cggtagtcgc ccctgtccgc gcagccgttc ccgcatcatt gctcgctgca ctggcgggcg
    19921 tagctaggcc cgcgcccgag ccgccaccag atgcggctct acctgcagat gccgagcgta
    19981 ctcctgcatc cgctccacgc tgcgagtggg cgttttccag ctcccgcttc ttcgcgcggt
    20041 attcatcaaa gccgcccaga taaaaggaca gctttccgtt ttccagctcc cacacgcgtc
    20101 cagccagctt attcacaaag tagcggtcat gggaaatggc tagcaccgtt cccgtgtagg
    20161 tgcccagcgc ttcctccaag gcctcgcggg aatcgatgtc cagatggttg gtcggctcat
    20221 ccagcaccag caaattcggc tttttcataa ccagcaacgc cagccgcaag cgagaccact
    20281 ccccaccgga cagcatgctc acaggtttaa acacatccgc accataaaat aaatacttcg
    20341 ccagctgccc gcgtgcttcg ccttcatcca gccctgcttc ctccttgaag taagcaagca
    20401 ccgtcgcccg gctattccgt tctctctctt gctgcgccaa atatccgtac tcgacgcgcg
    20461 cgccccattg gaccgtgcct gcatctacgc tttcctgacc aagcaacagc ttgagcagcg
    20521 tcgttttgcc cgcgccgtta ttgcctagca aagctacctt ttcaccaaat tccaggctgc
    20581 ctgttgcccc gtttaatatt tgacgttctc cataggcttt ggtgatgtcc tcgaattgaa
    20641 gcaccctgcg accggaacga tcctccaact ttaggtgaaa ctccgcacct tgagggtcca
    20701 gtacaggtcg cttcaccagc tccattcgtt ccagcgcctt gcggattgag gctgcctttt
    20761 tgaaaaactt ttcattatcg ccattgcgtc cccactcttc caaacggcga atggtctctc
    20821 tcatcttttt gatccgcttt tgctgctcct tataatcctc aaattgcagc agcagacgtt
    20881 cttccttctc cttaacgtag ccgctgtaat tcgtatagta cgtaaaggcc tcgccatcct
    20941 ccagttcgat catcttgccg gcaactcgat ccagaaaata gcgatcatgg gatacaacca
    21001 cacacgcacc tgcgtagccc tgcaaaaatt gctccagcca ttccaatcct ttcaaatcca
    21061 aatggttggt cggctcatcc agcaacagta gatctggtcg tccaatgagc tgtgatgcca
    21121 gcgctatttt ggttttttct ccgcctgaca gtgacccgaa gttgcgcgta tacatagctt
    21181 tgggaatacc tagcccatcc gctatctgat ccatactggc atccatttca tagccgccgt
    21241 tacgctcaaa ccgctcctgt agagaagcat acgtttgcaa cagcttctct aacagctcgg
    21301 gattcgctgc cacaaccgga tctgacattt cccgttccag tgtggtcatc tgattgcggc
    21361 aatccttcag ttcacgatag gcgtaagcca gcgtttcgta tacggtgaag ctttcaaact
    21421 ctgccgggat ttgcggcaaa tagccgattt tcgtatcctt ggcgatgacg agctgccctt
    21481 catctgggcg ggacaaacgc gcaattaggc gtaatagggt ggttttgccg cttccgttgc
    21541 gaccgataag ccccaccttt tctcccttat ggatatcaaa cgttgctcca tctaaaatca
    21601 gattggcagc gtggtatttt ttcaattgtt gaccgtttac aatatacatg ttcaggctct
    21661 cctttattta ggaagaccct tacccaggta acacaaaaag agccgcagga gcaaccccgc
    21721 gactcttcgg aagatatagc aatccgttgg agttaaggta ggcgtcttct cgcgatgttt
    21781 acaaccgtat gattaaaatt ggacagactt ctcccgttgt atggaaaagc atgaacaatg
    21841 ccagccatag caatcggcag ctggctaata cggttgttca gcatctcgtg attcacctac
    21901 ctcaccccct tcttcataat tggaagtagt ataacatgtt ttctcgtttt ataaaagagg
    21961 acaatgacct cccacctaag aaacagagtg gtgtcctctg actgtctgcg atgtgcccgc
    22021 tctggtaatc gaaaaaacgc cgcagacaaa agcaacaatc acaaatgtcc cgcctaccca
    22081 agcgtttgtg gcaacagact cgctattctc aatcactacc cctcccaagg cagaaccgag
    22141 agcgatcccg acctggagtg cggagaaatt aaagctttgc tgaatactac ccgattcggg
    22201 tgcattttca ataagataac tttgcatcgg gggcgacaag gcccaactca gaatccccca
    22261 gatgatcaga agcggcgcaa acatatacac cgagtgaatc gagaacggca gcaggaacat
    22321 cacggcaata aacacaccca cgacgatgag aatgcttttc gctgtgccga atcggtctgc
    22381 caaagagccg ccaataaaac ctccactcac tgccgccagc ccaaagacaa aataggctac
    22441 actcacccac gaggcgttca agcccatcag gttttccaaa aacggagtga aataagcata
    22501 caacgtgtag tgtcccgcca gtgtcagcgt tgttaccaga tgggcgctga ttactttaac
    22561 atttttcaag gacttcaact gctcacgcat aggcacaaca tgctctgttg gaatccgctc
    22621 cataaacaag tgcataatga tcatagaaac tacggtcaac aaggcaatga tcaggaatag
    22681 cacccgccag ccaaacgcat ttccaatcag caccccggct ggaatgccta gcacgatgga
    22741 agaacttacc cccatggaga tcacgccgag aacgcgggct tgataagctt tggacactac
    22801 tttgactgca atggttagcg acaatgtcac gatcaatgat ccactggcag cagtaatgat
    22861 acgagatata aacaacacag catagttcgg actccagaaa gccagcagac ttcccagaat
    22921 aaagataaac atcgaccaca aatacagtcg ctttcgttcg attttggcgg tcaacgccaa
    22981 caaagtcggc ccggcaatag cgtacacgag cgcatagatc atgatgagct gtcctgccgt
    23041 gcttacagag acgttcaaat cctgtgcaat ctggggcagc acgccaccga taatcaactc
    23101 caccagacct accgtaaagg tcgcaatggt taaaataact actttgaagt tcattacatt
    23161 agctcctttg ctgtcatgta aatccctcgc atcacgcaaa aaaatcctga ccacaagaaa
    23221 tgtacaagac gtacactttt tgtaatcagg atttatcggt tcctggtaga gaccctcaaa
    23281 ccatattatt gaggttatac aaatggggta ttcatttatt acgcttcacg aaggttatag
    23341 ctattactat aaaggagcct ctggttaagt tcaaccccta cagccgcaaa aattcgctca
    23401 tggcacgatc tgacagatag ggtaaatact catgaccgta ttcgtgatac acaagcaatt
    23461 ccttgtccga tacgatttta ttgtacaccg caaactgtgt ggaaggtggg caaatcacat
    23521 ccgatagccc tgtcacgaat agcacccgtc ctcgaatacg gtctgctaaa tgttgaatgt
    23581 cgatgtagcc taagcggtga aacacttcgc tctcacgtac atgattggga tcaaaccagc
    23641 gaaaataata aaccagttcc tcataggccg atgtcgttgc atccagcgcc caagctcttt
    23701 tatagtccga caggaacgga tataccggta ccgccacacg gacacgcggc tccaatgcag
    23761 cgcaagcaac cgttagtgcc ccgccttggg agcagccaaa tgcaccgatc cgttcagggt
    23821 caacctgctc catagacatt agaatgcgca ccgtctgcac cgtatccaaa aatacgttgc
    23881 ggtagtacaa ccgatccggg tccgggtcgt caattccgcg gataatatga cctcgaaccg
    23941 tcgttccctg aacctgcaaa ttgtcctcag acagcccgcc ttgccctcgg cagtccatgg
    24001 ccagcacagt gaatccgtgt gccgcatagc tcaccttgtc gaaccagtcg ccactgtcgc
    24061 aggaataccc atgaaacata gccaaggctg gaccttgttc cgtaagatgc ttgggacgag
    24121 ccagcttccc atgaaccctc gctccgccca ctccagtaaa atacagatgg taacactcca
    24181 ccagcggaga gacaaattcg gcaggctcaa gtgtatattc cagtggctgt cgttccagct
    24241 cctgtagcgc ccgttcccag tacatatcaa aatcctgcgg ctttggatta cttcccatgt
    24301 atgactgtag ctgctgtaaa gacatatcct ccggcatgta aaattcctcc tacatccggc
    24361 ctgactcacg atcatctgcg actacttcat ccgtcgcgat gacatacttt ataatgtcag
    24421 atactgtcgt gtatgcgata cctacatacg tatcagcggc tccataataa atcgcaattc
    24481 ttccggtgtc cgcatcatgc agtgtagcac acgggaacac cacatttggc acaaatcccc
    24541 gctcttcgta ccattcctct ggggtcaaca cgaagttgga ggaacgatat ttgactttgg
    24601 aaggatcatc cagatcaaga acagctacac ccatgctgta taccagtcca ttgcatgtgc
    24661 ctgtcacccc gtgatagaac atcagccagc cctctgtcgt ctcaatcggt gctggtccgc
    24721 caccaatctt caccgattgc caccagccct gaccaccctt gctcattaca tgacgatgct
    24781 tgccccaata caccaagtca ggactttcgc tcaggaaaat atcaccaaac ggagtatgac
    24841 cactgtcgct cggacgggat agcaacataa agtttccatt tagcttacga ggcaacagca
    24901 ctccattgcg attaaacggc aagaacggat tttccaagcg cacaaagctt ttgaaatcct
    24961 tcgtttgtgc gattcccagc gctgcaccat agaaatctgt acaccagatg atataatacg
    25021 tgtcttccac tcgaaccaga cgcggatcgt aagcataatt aggctgatat tcatttcctt
    25081 cctcatcgac catatgcaga cgctctgtct caatgtccca agccagcccg tcgtcactcc
    25141 agccgagatg caaatgcggg cgtccattaa tcgtttcagc acggaatatc cctacaaacc
    25201 gtccttcata cggagctacg gcactgttga aaatacgggc aatgccaggc accggatttc
    25261 gtccaatgac cggattctca gtatgcctcc atactggagc ctcactgcct tccggcttat
    25321 cctgccaagg cattttcgac aagctgtctc ctacaattcg tacgttacct acatccaaat
    25381 ccacattcaa tttactcata cttaactctc ctctcaccta gacacttcat tttatttttt
    25441 tctatttcac tgaaccctgt gcaaatccgt tatagatata tttttgtaat gataaaaatg
    25501 caaccagcgt cggaataatc gcaatgatga tgcctgcgct aatgacttcc cattgcgaac
    25561 cgtatggccc tttaaactta aacagtgccg tcgatatcac ctgaaggctt gttttgggca
    25621 tatacaggaa cggggtgtaa aaatcgttgt aaatattaac acccttgatg ataattaccg
    25681 tcacaatggc aggcttcagc agcggcaaaa taatgcgcca gtagatggtc agataggagg
    25741 ccccatccag catggcagac tcatccagcg ccaccgcgat ggaatccaga aactgaagga
    25801 aaatatacac cgcgataata tcggttccta aatacagtaa aatggctgcc caaggtgtgt
    25861 taaacagttc cagcttgtta atgatctgga atgtcgatac ctgtgtcgtc acccccggaa
    25921 tgagcgtggc gagtaagaac gcacccagca tgagactttt acctttaaat ttaaagcgat
    25981 tcaaaatata cgcgatcatg gaaccggtca acgtagcccc gatgatggaa atcagcaaaa
    26041 taaaggctgt gttcaaaaat ccggttagca tatttccatc cacaaaggcc ttggcgtagt
    26101 tcgcccagtt cagccagttc accgggggag tcagaggact ggttgccgca tattcagcct
    26161 tcgtcttcaa agatgcaaac aaaatcacaa caattggcag tagagcaatg aacgcaccta
    26221 gcaatagcgc accatacttg atggtgtttg ccagtaatct ttttagctta tacatgatta
    26281 gtcctcctcc c
//
