LOCUS       NZ_LJIW01000001        22000 bp    DNA     linear   CON 11-JUN-2024
DEFINITION  Streptomyces malaysiensis strain F913 SMF9131, whole genome shotgun
            sequence.
ACCESSION   NZ_LJIW01000001
VERSION     NZ_LJIW01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces malaysiensis
  ORGANISM  Streptomyces malaysiensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
REFERENCE   1  (bases 1 to 6203920)
  AUTHORS   Xu,Y., Wei,J., Xie,J., Li,T. and Zhou,Z.
  TITLE     Genome sequence, genome mining and natural product profiling of a
            biocontrol bacterium Streptomyces malaysiensis F913
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6203920)
  AUTHORS   Li,T. and Zhou,Z.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2015) State Key Laboratory of Silkworm Genome
            Biology, Southwest University, Tian Sheng Road, Beibei, Chongqing,
            Chongqing 400715, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 10-FEB-2015
            Assembly Method                   :: SOAPdenovo v. 2.04
            Expected Final Version            :: yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002891865.1-RS_2024_06_11
            Annotation Date                   :: 06/11/2024 05:20:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,419
            CDSs (total)                      :: 9,336
            Genes (coding)                    :: 9,091
            CDSs (with protein)               :: 9,091
            Genes (RNA)                       :: 83
            rRNAs                             :: 5, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (16S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 245
            CDSs (without protein)            :: 245
            Pseudo Genes (ambiguous residues) :: 0 of 245
            Pseudo Genes (frameshifted)       :: 59 of 245
            Pseudo Genes (incomplete)         :: 218 of 245
            Pseudo Genes (internal stop)      :: 14 of 245
            Pseudo Genes (multiple problems)  :: 43 of 245
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:22:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1961062
            Orig. end                         :: 1983062
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LJIW01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22000
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="12"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22000
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22000
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12000](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12000
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(146..574)
                     /locus_tag="SMF913_RS07565"
                     /old_locus_tag="SMF913_11475"
     CDS             complement(146..574)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058761.1"
                     /locus_tag="SMF913_RS07565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11475"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_069871363.1"
                     /transl_table=11
                     /translation="MKRQDLDDLVRLRRARDRMDRDYAEPLDVPALARGALMSPGHFSR
                     SFRAAFGETPYSYLMTRRIERAKALLRRGDLSVTEVCIAVGCTSLGSFSSRFTQLVGES
                     PSSYRARSHDHGAAIPACMAKIHTRPVRNGEARPAARP"
     gene            697..1107
                     /locus_tag="SMF913_RS07570"
                     /old_locus_tag="SMF913_11476"
     CDS             697..1107
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012894118.1"
                     /locus_tag="SMF913_RS07570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11476"
                     /product="VOC family protein"
                     /protein_id="WP_069871536.1"
                     /transl_table=11
                     /translation="MDLTIHWTFLPHDDPDASLAFYRDTLGFEIRKDVGYDGMRWLTVG
                     PAGQPGTSIVLEPPALDPGITDDERRTIVEMMAKGSYARLTLATADLDGVFARVRSSGA
                     EVVQEPTEQPYGIRDCAFRDPAGNMIRINELR"
     gene            1231..3624
                     /locus_tag="SMF913_RS07575"
                     /old_locus_tag="SMF913_11477"
     CDS             1231..3624
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013000733.1"
                     /locus_tag="SMF913_RS07575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11477"
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_102933755.1"
                     /transl_table=11
                     /translation="MSMATETGTRSPAPHAADSHDLIRVHGARENNLKDVSIEIPKRRL
                     TVFTGVSGSGKSSLVFNTIAAESQRLINETYSTFVQGFMPTLARPEVDVLEGLTTAIIV
                     DQQRMGADPRSTVGTATDANAMLRILFSRLGEPHIGPPGAYSFNTASVSASGGFTVDRG
                     AEKTRTEKVSFSRTGGMCTHCEGRGTVSDIDLTQLYDDSKSLSEGPFTIPTYTGDGWVV
                     RVITESGFFDRDKPIREYTKRERHDFLHREPTKVKINGVNLTYEGLIPKLQKTFLAKDR
                     ESMQPHIRAFVDRAVTFARCPECDGTRLSEAARSSRIGKVSIADACAMEIRDLSEWIRG
                     LDEPSVAPLLAKLQHTMDSFVEIGLGYLSLDRASGTLSGGEAQRVKMIRHLGSSLTDAT
                     YVFDEPTTGLHPHDIQRMNNLLLRLRDKGNTVLVVEHKPETIAIADHVVDLGPGAGTAG
                     GAVCFEGTVEGLRDSDTVTGRHLDDRAVLKETVRKATGTLEIRGATANNLRDVDVDVPL
                     GVLCVVTGVAGSGKSSLIHGSIPVPEGVVSVDQTPIRGSRRSNPATYTGLLDPIRKAFA
                     KANGVKPALFSANSEGACPTCNGAGVIYTDLAIMQSTATTCEECDGRRFDASVLEYHLG
                     GLDISEVLAMSVVEAEEFFGGGAARTPAAHRILQRMADVGLGYLRLGQPLTTLSGGERQ
                     RLKLAVHMADKGGVYILDEPTTGLHLADVQQLLGLLDRLVDSGKSAIVIEHHQAVMAHA
                     DWIIDLGPGAGHEGGEVVFEGTPADLAAARSTLTGEHLAEYVGG"
     gene            complement(3698..4876)
                     /locus_tag="SMF913_RS07580"
                     /old_locus_tag="SMF913_11478"
     CDS             complement(3698..4876)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069051.1"
                     /locus_tag="SMF913_RS07580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11478"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_102933756.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.5e-26, bitscore:
                     91.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 8.4e-21, bitscore:
                     72.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.5e-31, bitscore:
                     107.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLEYTPDQRRLRDELRAYFAELVPDDAYARYADSTGQKRFYRAT
                     IRRLGSDGWLGVGWPQEYGGRGLGPVEQFIFFDEAAQAGVPLPLMALNTVGPTIMRFGT
                     EEQKGYFLPKVLSGEIDFAIGYSEPDAGTDLASLKTRAVRDGDDYIINGQKTWTTNGDT
                     ADWVWLAVRTDPEAKPHKGISILLVPTDDPGYSATLIRTLASHDTTASYYENIRVPATR
                     RVGAENEGWRMITTQLNYERVTLAAHGTMAIRALRGVRQWAADTKLPDGRRVIDLGWVR
                     GRLARTHARLDAMKLLNWQMVEALQRDALTPQDASAVKVYGSEARRDAYAWLMEIVGAA
                     GPLKEGSAGEVLHGELERGYRSSVVFTFGGGNNEVQREIISWIGLGMPRVRR"
     misc_feature    complement(4988..5001)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(5013..7121)
                     /locus_tag="SMF913_RS07585"
                     /old_locus_tag="SMF913_11479"
     CDS             complement(5013..7121)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058770.1"
                     /locus_tag="SMF913_RS07585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11479"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_069871356.1"
                     /transl_table=11
                     /translation="MENTAAPAAAVLPPRPQPRQPRRYRRPAPWLGLVAIGYAVVQLAM
                     VIPHTGHALGWDESVYVSQVDPRTPPAYFSAPRSRGVSLLVAPVVAATDSIPVLRVLLM
                     LLSAGALYGAFRVWARLLPPPQVALAALLFSGLWITQISGPAVMPNLWVAIGAVAAVGW
                     FLRAPDEPNARWWLAAVLAGVTLVRTPDGGWLALPLLIGAIGVRTWRPALPALIGGPLL
                     GAAQWIGEAYDRFGGIGGRLNVSSHVEGGMGLHFSVGAALRSLNGPQLCRPCEVPLRHP
                     ELTVWWLALPVLTLLAVHAALRDRQELRRVRVGLGRPAARPPAVPLTLLPIVCAAALAL
                     PYLLLIDYSAPRFLMPSYALLALPIAGLVFRAVRAARSPQHLAVALGVIVTLHLASQFV
                     ILDHTAKQSDTTTGRYRTAAQGLQRLGLRPPCLVTGDRALPIAYHAGCSSAQTSGNNRS
                     TTLPSLLRRAAREPTALLLRRGQARPPSYARTWVGYPLPGTEWNAYLPPDQARESEAAK
                     SRQETSGNGASMGAMTTTYPTTSWAGFEAAEPTFAGYAQDRFRRYRHHVLATLRQDGSP
                     RVTPLEVTFLSGELWLGMMPDSRKALDLRRDPRFSVQANPGPGDGLTEGDVRVSGRAVE
                     VTDPEAVARFAEAVRPPEPFHLFRTEVTEVVHTASENGEMVLRTWRPGRPVQVVRRGSD
                     DSPPRVEG"
     misc_feature    7263..7278
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.75"
                     /tool="antismash"
     gene            7264..8256
                     /gene="dhaK"
                     /locus_tag="SMF913_RS07590"
                     /old_locus_tag="SMF913_11480"
     CDS             7264..8256
                     /EC_number="2.7.1.121"
                     /GO_function="GO:0004371 - glycerone kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006071 - glycerol metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="dhaK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058771.1"
                     /locus_tag="SMF913_RS07590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11480"
                     /product="dihydroxyacetone kinase subunit DhaK"
                     /protein_id="WP_069871354.1"
                     /transl_table=11
                     /translation="MKMLINVPETVVADALRGLAACHPELTVDIENRVIVRRDAPVEGK
                     VALISGGGSGHEPLHGGFVGPGMLDAACPGEVFTSPVPDQMVRAAAAVDSGKGVLFIVK
                     NYTGDVLNFDMAAELAEDEGIQVAKVLVNDDAAVTDSLYTAGRRGTGATLFVEKIAGAA
                     AEEGAPLERVESIARRVNEVSRSFGVALSACSTPAKGGPTFDLPAGELELGVGIHGEPG
                     RERRAMMTSREIADYAVEVVVEDLRPDNPVLLLVNGMGATPQLELYGFAAEVHRALGER
                     QVAVARTLVGNYVTSLDMAGASITLCQVDEDLLRLWDAPVRTAGLRWGA"
     misc_feature    complement(7265..7279)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.24"
                     /tool="antismash"
     misc_feature    complement(7266..7281)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.07"
                     /tool="antismash"
     misc_feature    7269..7284
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.07"
                     /tool="antismash"
     gene            8316..8951
                     /gene="dhaL"
                     /locus_tag="SMF913_RS07595"
                     /old_locus_tag="SMF913_11481"
     CDS             8316..8951
                     /EC_number="2.7.1.121"
                     /GO_function="GO:0047324 - phosphoenolpyruvate-glycerone
                     phosphotransferase activity [Evidence IEA]"
                     /GO_process="GO:0006071 - glycerol metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="dhaL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058772.1"
                     /locus_tag="SMF913_RS07595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11481"
                     /product="dihydroxyacetone kinase subunit DhaL"
                     /protein_id="WP_102933757.1"
                     /transl_table=11
                     /translation="MSSSEPAVDDVLDTPFFLRWLTAAAAAVSREAARLTDLDSAIGDA
                     DHGTNMQRGFAAVAEALEKEPPGSPGATLILAGRQLISKVGGASGPLYGTLLRRAGKAL
                     GDAERITPQQLADALRAGVDAVAQLGGAAPGDKTMLDALLPAVEALGTGAGSFAAAGEA
                     AEKGALATVPMLARKGRASYLGERSVGHQDPGATSSALLIAALAEAAR"
     gene            8948..9364
                     /gene="dhaM"
                     /locus_tag="SMF913_RS07600"
                     /old_locus_tag="SMF913_11482"
     CDS             8948..9364
                     /EC_number="2.7.1.121"
                     /GO_function="GO:0047324 - phosphoenolpyruvate-glycerone
                     phosphotransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="dhaM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019526857.1"
                     /locus_tag="SMF913_RS07600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11482"
                     /product="dihydroxyacetone kinase phosphoryl donor subunit
                     DhaM"
                     /protein_id="WP_069871352.1"
                     /transl_table=11
                     /translation="MTDEGEKKLVGIVLVSHSAAVADSVAEMAKGLSGGGTAPVRAAGG
                     TEDGGFGTSPELIAEAAHAVDRGAGVAVLVDLGSAVLAVKALLAEGDELPEGTRLVDAP
                     LVEGAVAALVTASTGADVEAVLQAASEAYDYRKV"
     misc_feature    9911..9924
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.48"
                     /tool="antismash"
     misc_feature    9912..9925
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.56"
                     /tool="antismash"
     gene            10001..11080
                     /locus_tag="SMF913_RS07605"
                     /old_locus_tag="SMF913_11483"
     CDS             10001..11080
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058774.1"
                     /locus_tag="SMF913_RS07605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11483"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_069871350.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.2e-51, bitscore:
                     173.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPTLSPGRLDADTVRESVDVVLEDFLAAKARTTPQHHLPYLSG
                     LLRDFLSGGKRIRPLLCVTGWQAVGNGEDTEAVFRVAACLEMFHAFALIHDDVMDDSDT
                     RRGRPTIHRTLAALCAADRRPDQIERFGVGGAVLLGDLALTWSDELLHSAGLTPAQFNA
                     VLPLLSEMRTEVMLGQYLDLQATGELTDDIEATLTVIRYKTAKYTIERPLHVGAAIAGA
                     GPDAMEAISAYALPLGEAFQLRDDLLGVYGDPESTGKSQLDDLRAGKNTTLIALALRGS
                     DSVQAARLRSLIGNPLLDERDAATVQEIFAATTAREAVEQMIDDRRTQALRALDDAPFT
                     ADAVHALKQIARMATVRNS"
     gene            11077..12000
                     /locus_tag="SMF913_RS07610"
                     /old_locus_tag="SMF913_11484"
     CDS             11077..12000
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058775.1"
                     /locus_tag="SMF913_RS07610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11484"
                     /product="terpene synthase family protein"
                     /protein_id="WP_099012745.1"
                     /sec_met_domain="T1TS (E-value: 5.2e-16, bitscore: 57.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTGPSTAGAQDISRTSVRPYLEECTRRFQEMFDRYVVTRPTKVE
                     LTDAELREVIDDCNAAVAPLGKSVSDERWISYVGVVLWSQSPRHIKDMEAFKAVCVLNC
                     VTFVWDDMDPALHDFDLFLPQLRKICEKYYGPEDAEVAYEAARAFVTSDHMFRDSPIKA
                     ALCTTSPEQYFRFRVTDIGVDFWMKMSYPIYRHPEFTEHAKTSLAARMTTRGLTIVNDF
                     YSYDREVSLGQITNCFRLCDVSDETAFKEFFQARLDDMIEDIECIKAFDQLTQDVFLDL
                     IYGNFVWTTSNKRYKTAVNDVNSRIR"
     gene            12015..13376
                     /locus_tag="SMF913_RS07615"
                     /old_locus_tag="SMF913_11485"
     CDS             12015..13376
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000061: Hydroxylation (95% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058776.1"
                     /locus_tag="SMF913_RS07615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11485"
                     /product="cytochrome P450"
                     /protein_id="WP_079256571.1"
                     /sec_met_domain="p450 (E-value: 1.4e-83, bitscore: 279.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPAKSSAQPERSWTTGTAPGSVPLLGHTLALWRQPLQFLASLPA
                     HGDLVEVRLGPSRAYLVCHPELVRHVLLNPRTFDKGGVFDKARQLLGNSLSVSRGEEHR
                     SQRRMIQPAFHTPKISAYTAAVADDTRAAIGSWEPGRTLDISDTMHALLMRVAARTLFS
                     TGIDEATIDEARHCLRTVSDGIYKRTMAPLGIMEKLPTPGNRRYDRANARLRQIVDEMI
                     RDRRRSGTDHGDLLSTLLRAEHPETGKGLDDGEVLDQVVTFLVAGSETTASTLAFVFHL
                     LGAHPEVEKRVHAEIDEVLEGRVATFEDLPSLEYTRGVITESLRLYPPSWMAMRVTAAE
                     TELGGRTIPAGTMILYSAQALHHNPELFPDPERFDPERWLPGRAEEVPRGALLPFGAGS
                     HKCIGDVLALTETALIVATIASRWRLRPVPGTTLRPEPKATLEPGPLPMVCEPR"
     gene            13459..14820
                     /locus_tag="SMF913_RS07620"
                     /old_locus_tag="SMF913_11486"
     CDS             13459..14820
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000062: Hydroxylation (94% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058777.1"
                     /locus_tag="SMF913_RS07620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11486"
                     /product="cytochrome P450"
                     /protein_id="WP_069871531.1"
                     /sec_met_domain="p450 (E-value: 1.3e-79, bitscore: 266.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTAQHPATRHWRHALAPGGLPLAGHALLMGRKPLQFLASLPAHG
                     DLVELRLGPRPVFLPCHPELVQQVLVNARIYDTGGPVKEKAKPILGNGLITSDWADHRR
                     QRRLVQPAFQAARIAKYAEVMEEECAAESTAWSARRPIDVSHEMLALTARVTARALFST
                     DMAPHAVAEIQHCLPIVVEGAYRQAIDPTGLLARLPLAANRRFDDALHRLNQLIDRMID
                     DYKAADDGDRGDVLSALFAAQDDETGGTMSDQEIHDQVMTLLLAGIETTASALTWTWFL
                     LGRNPRAEAALHAEVDEVLGGRAPVYADVPRLAHTQRVFSEALRLFPPAWLFTRTTTEA
                     TELGGRRLPPGSDVLISPYVMHRDPALFPDPESFDPDRWLPERAKDVARNSYLPFGGGS
                     RKCIGDVFGMTEATLALAAIAGRWRMRPIPGTKIRPRPQMSLTAGPLRMIPEPR"
     gene            complement(15033..16226)
                     /locus_tag="SMF913_RS07625"
                     /old_locus_tag="SMF913_11487"
     CDS             complement(15033..16226)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741294.1"
                     /locus_tag="SMF913_RS07625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11487"
                     /product="cytochrome P450"
                     /protein_id="WP_069871343.1"
                     /sec_met_domain="p450 (E-value: 1.8e-16, bitscore: 58.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQDLSALGADFVVNPYPVYARLRERGPVHRVRTDTSGVFWLVVG
                     HEEARAALTDPRLSNDVRHSAAWQDDGGNAIGRNMVQTDPPHHTRLRGLVARTFTPGRI
                     EALRPRVQRIADELLDAMVPLGRADLVEDYALPLPLAVICELLGVPETDRKAFHDWYLE
                     STDLTCPETAGAAAQALTGYFAELIESKRRAPGDELLSALVRTMEGDGDALSAEEMLGM
                     TFVLLVAGYETSANLISSGTLALLRHPGQLAALRADWSLLEGAIEEMLRYDGPVESAAF
                     RFTREPVEIAGTAIAAGEPVAVALAAGSRDPRRFAEPDRFDIRRSSRGHLAFGHGVHHC
                     LGAPLARLEGAVAFRALLERCPDLALDGDPAELAWRPSLMLRGLRRLPVRFSTAPDA"
     gene            16350..17030
                     /locus_tag="SMF913_RS07630"
                     /old_locus_tag="SMF913_11488"
     CDS             16350..17030
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058778.1"
                     /locus_tag="SMF913_RS07630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11488"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_069871341.1"
                     /transl_table=11
                     /translation="MGSRVEKETPLRRDARRNREMLITAAREIYTDQGVDAPLDDIARR
                     AGVGSATLYRRFAGRAELIEAVFGDSLRDILRAAEEARSAVDAWVGLTAYLERIFGLLA
                     ADRGTNDLMTTGIQGVPSLDALREENAKTLDVLLRRAQEQGAVRKDATAEDLQFMLAAL
                     GRAVPGSTVAAPLAWRRYLFLLLDGLRPEGSHPLPAPSLTTEQLNAAMLQLGKVRRPRA
                     GRAD"
     gene            17285..18712
                     /locus_tag="SMF913_RS07635"
                     /old_locus_tag="SMF913_11489"
     CDS             17285..18712
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1074: major
                     facilitator family transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058779.1"
                     /locus_tag="SMF913_RS07635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11489"
                     /product="MFS transporter"
                     /protein_id="WP_102933758.1"
                     /transl_table=11
                     /translation="MPTPDSPASAPPTPPGSLRRIVAASLIGTTIEWYDFFLYGSAAAL
                     VFNKLFFPDSDPLVGTLLSFLTYAVGFAARPVGALVFGHYGDRLGRKKLLILSLLMMGG
                     ATCAIGLLPTHATVGSAAPVLLTALRLLQGFALGGEWGGAVLLVSEHGDARRRGFWASW
                     PQTGAPAGQLLATGVLSALTALLSDSAFESWGWRVPFLLSGVLVVVGLWIRLSVDESPV
                     FKAALARAEARKAATDGGADAAEKMPLVAVLRHHWRDVLIAMGARMAENISYYVITAFV
                     LVYATSDHVGLGKQTALNAVLIASAVHFAVIPAWGALSDRIGRRPVYLLGAAGVGAWAF
                     PFFLLIDTKGFPALLLAVTVGLIFHGAMYAPQAAFFSEMFATRMRYSGASIGAQFSSVA
                     AGAPAPLIATALLADYDSATPIALYVIAAALLTLVAVGVAKETRDRDLAAVEPTSAHSP
                     RPASEGAGRKARSASAQ"
     gene            complement(18706..20820)
                     /locus_tag="SMF913_RS07640"
                     /old_locus_tag="SMF913_11490"
     CDS             complement(18706..20820)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058780.1"
                     /locus_tag="SMF913_RS07640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11490"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_102933759.1"
                     /transl_table=11
                     /translation="MPVTMPDDRPEAPYLELLVRGAPAEAYERPVLRARADKAPADLLA
                     ALERAKLLALRVRGELEGRRRREAELSALFETAHDLAGLRDLDAVLQAIVQRARSLLGT
                     EVAYLTLNDPTAGDTYMRVTDGSVSARFQQLRLGMGEGLGGLVAQTARPYVTENYFDDP
                     RFQHTHAIDAGVRDEGLVAILGVPLLLGSGVIGVLFAADRRARVFEREQIALLGSFAAH
                     AAVAIDTAHLLAETRTALAELEAANEIIRDRSRVIERASDVHDRLTELVLRGGGVHDVA
                     DALAEVLSGSVEFLETDEAPAAAVDRSRADGHAVRDGEEDWVAAVSAGGELLGALVLRG
                     HPRLDPMDQRTLERAAMVTSLLQLARRSAGEAEQRVRGELLDDLLDAPDREPRLLRERA
                     ARLRADLDTPHVVLAAGIEAPDTGTPAAGPGGAPGSGPGTTPGGGPGTAPASGPGGARA
                     SGPGGASGSRPGGAPGAGPGGGPGGAPAEDAAGRRRLWSAASHLAVTRHGLAAARDGGT
                     VLLLPLAEGDTADALARRTARQLGTAVHAAVTVGASAPVPAPAARPGDVAAGYAEARRC
                     LAALRVLDRAGQGAAAEDFGFLGLLLAGTREGAPAGTGVQDFVQRTVGAVIDYDERRGT
                     ELIRTLDAYFAGGMSPARTKDALHVHVNTVAQRLERIGRLLGPDWQSPARSLEIQLALR
                     LHRLASAVGY"
     misc_feature    20984..20998
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
     gene            complement(21090..21896)
                     /locus_tag="SMF913_RS07645"
                     /old_locus_tag="SMF913_11491"
     CDS             complement(21090..21896)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058781.1"
                     /locus_tag="SMF913_RS07645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SMF913_11491"
                     /product="3-hydroxybutyrate dehydrogenase"
                     /protein_id="WP_079256574.1"
                     /sec_met_domain="adh_short (E-value: 1.9e-29, bitscore:
                     101.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSASTTPGPGPRPSDGPDLSCRTALVTGAAGGIGRACTLRLATAG
                     ARVRAVDLDAEGLTDLVDAAAGLPGQVEAHPLDLTDLDAAERAAAGIDILVNNAGLQLV
                     RPIEDFPPEVFSRVLTVMLEAPFRLVRGALPHMYARGWGRIVNISSVHGLRASPYKSAY
                     VAAKHGLEGLSKVAALEGAAHGVTSNCVNPGYVRTPLVERQIADQAEAHGISPERVVSD
                     VMLADSAVKRLVEPEEVAEAVAYLCGPHTSFVTGASLSMDGGWTAH"
ORIGIN
        1 cccgacggtc acccagcgca tcccctcgaa cccgacgtca ttgcggacct cgaggccgag
       61 tacatcgcgg tagaagggga tcgccttgtc gtggtcgtcg acggcgatga aacattggga
      121 gagcgtgatg tccatgccgc tcacgctacg gccgggcggc gggacgcgct tctccgttcc
      181 tgaccggccg cgtgtggatc ttggccatgc acgccgggat ggcggcgcca tggtcatggc
      241 tccgggcccg gtagctgctc gggctctcgc cgaccagctg tgtgaagcgc gagctgaacg
      301 accccagcga ggtacagccc accgcgatgc agacctcggt caccgagagg tcgccgcgcc
      361 gcagcagcgc cttggcccgc tcgatgcggc gggtcatgag gtagctgtac ggcgtctcgc
      421 cgaaggcggc ccggaagctg cgggagaaat ggccgggcga catcagggcg ccccgcgcca
      481 gcgccgggac gtcgagcggc tcggcgtagt cgcggtccat ccggtcgcgg gcccgccgca
      541 gccggacgag gtcatcgaga tcctgccgtt tcacccgctc agcttcgcac agcgcccagg
      601 ggcgcggacg aggggcggcg accgggagcg agaggcgacc ggaccggtca ggaatggaga
      661 agccccggtc ggaagggcgc ggctagcgtg accgccatgg acctcaccat tcactggacc
      721 ttccttccgc atgacgaccc ggacgcctcc ctggccttct accgcgacac cctcggcttc
      781 gagatccgta aggacgtcgg gtacgacgga atgcgctggc tcacggtcgg ccccgcaggc
      841 cagcccggaa cctccatcgt cctggagcct ccggccctcg accccggcat caccgacgac
      901 gagcgccgca ccatcgtgga gatgatggcc aagggcagct acgcccgtct caccctggcc
      961 accgccgacc tcgacggcgt cttcgcccgg gtgcggagca gcggcgccga ggtcgtccag
     1021 gaaccgaccg agcagccgta cgggattcgc gactgcgcct tccgcgaccc cgcgggcaac
     1081 atgatccgca tcaacgagct gcgctgagcc ctccggcgac ggcggccacg acccgcgaac
     1141 cggacgtatt gttcgaagcc gaccaggtcg agccaggcga caccggtggg gaccgcgaag
     1201 acggtccccg cccgaacaga tggagacacg atgagcatgg ccacggagac gggcacgcgg
     1261 tcgcctgcgc cccacgccgc cgacagccac gatctgatcc gggtgcacgg cgcgcgcgag
     1321 aacaacctca aggacgtcag catcgagatc ccgaagcgcc ggctgacggt gttcaccggc
     1381 gtctcgggct cgggcaagag ctcgctggtg ttcaacacga tcgccgcgga gtcacagcgg
     1441 ctgatcaacg agacctacag cacctttgtg cagggcttca tgccgacgct ggcgcggccc
     1501 gaggtcgatg tgctcgaggg gctgaccacc gcgatcatcg tggaccagca gcggatgggt
     1561 gccgatcccc gctccacggt cggcaccgcc accgacgcca acgcgatgct gcgcatcctc
     1621 ttcagccggc tcggcgagcc gcatatcggc ccgcccggcg cgtactcctt caacaccgcc
     1681 tcggtctcgg cgagcggtgg gttcacggtc gaccgcggcg ccgagaagac caggaccgag
     1741 aaggtgtcct tcagccgcac cggtggcatg tgcacgcact gcgagggccg gggcacggtc
     1801 tccgacatcg acctcaccca gctctacgac gactccaagt cgctctccga gggtccgttc
     1861 accatcccca cctacaccgg ggacggctgg gtcgtgcggg tcatcaccga gtcgggcttc
     1921 ttcgacaggg acaagccgat ccgtgagtac accaagaggg agcggcacga cttcctccac
     1981 cgcgagccca ccaaggtgaa gatcaacggc gtcaacctca cctatgaggg gctgatcccg
     2041 aagctccaga agaccttcct cgccaaggac cgcgagtcga tgcagccgca tatccgggcg
     2101 ttcgtggacc gggcggtcac cttcgcccgg tgtcccgaat gcgacggcac ccggctgagc
     2161 gaggcggccc ggtcctcccg gatcggcaag gtcagcatcg ccgacgcctg cgcgatggag
     2221 atccgcgacc tgagcgaatg gatccgtggg ctggacgagc cgtcggtggc gccgctgctc
     2281 gccaagctcc agcacaccat ggactcgttc gtggagatcg gcctcggcta cctctcgctc
     2341 gaccgggcct cgggcacgct ctccggcggc gaggcacagc gcgtcaagat gatccgccac
     2401 ctgggctcct cgctcaccga cgccacctac gtcttcgacg agcccaccac gggtctgcac
     2461 ccccatgaca tccagcggat gaacaacctg ctgctgcggc tgcgggacaa gggcaacacg
     2521 gtgctcgtgg tggagcacaa accggagacg atcgccatcg ccgaccatgt ggtggacctc
     2581 ggcccgggcg ccggtacggc gggcggcgcc gtctgtttcg aggggaccgt cgaggggctg
     2641 cgcgacagcg acaccgtcac cggccgccac ctggacgacc gggcagtgct caaggagacg
     2701 gtgcgcaagg ccaccggcac gctggagatc cgcggcgcga cggcgaacaa cctgcgcgat
     2761 gtcgacgtgg acgtcccgct cggcgtgctc tgtgtggtca ccggcgtcgc cggctccggc
     2821 aagagctcgc tcatccacgg ttccatcccg gtcccggaag gtgtggtctc ggtggaccag
     2881 accccgatcc gcggttcgcg gcggagcaac ccggccacgt acaccgggct gctcgacccg
     2941 atccgcaagg cgttcgccaa ggccaacggc gtcaaaccgg cgctgttcag cgccaactcc
     3001 gagggcgcct gccccacctg caacggcgcc ggcgtcatct acaccgacct ggcgatcatg
     3061 cagagcaccg ccaccacctg cgaggagtgc gacggcaggc gattcgacgc gtcggtgctc
     3121 gagtaccacc tcggcggcct tgacatcagc gaggtgctcg cgatgtcggt ggtcgaggcc
     3181 gaggagttct tcggcggcgg cgcggcgcgc acaccggccg cccacaggat cctccagcgg
     3241 atggcggacg tcggcctcgg ctatctccgc ctcggccagc cgctcaccac gctgtccggc
     3301 ggtgagcggc agcggctcaa gctggccgtg cacatggccg acaagggcgg tgtctacatc
     3361 ctcgacgagc cgaccaccgg gctgcacctc gccgacgtgc agcagctgct cgggctgctc
     3421 gaccggctgg tcgactccgg caagtcggcc atcgtcatcg agcaccacca ggccgtcatg
     3481 gcacacgccg actggatcat cgacctcggc cccggcgcgg gccacgaggg cggcgaggtc
     3541 gtcttcgagg gcacacccgc cgacctcgcc gccgcccgct ccaccctcac cggcgagcac
     3601 ctggcggagt acgtcggcgg ctgaccggag gcgtcggcgg ctgaccggag gcgtcggcgg
     3661 ccgaccgggg cgtcgcggga agcgccgtcg cggcggctca gcggcgcacc cgtggcatcc
     3721 ccaggccgat ccaggagatg atctcccgct ggacctcgtt gttgccgccg ccgaaggtga
     3781 agacgacgct gctgcggtag ccgcgctcca gctcaccgtg gagaacctcg cccgccgagc
     3841 cctccttcag cggtccggcg gcgccgacga tctccatcag ccaggcgtag gcgtcgcggc
     3901 gcgcctccga gccgtacacc ttgacggcgg aggcgtcctg cggggtgagg gcgtcgcgct
     3961 ggagggcctc caccatctgc cagttgagca gcttcatggc gtccagccgg gcgtgcgtac
     4021 gggccagccg gccgcgcacc cagcccaggt cgatcacccg gcggccgtcg gggagcttgg
     4081 tgtcggcggc ccactggcgg acgccgcgca gggcgcggat ggccatggtg ccgtgggcgg
     4141 cgagggtgac ccgttcgtag ttgagctggg tggtgatcat gcgccagccc tcgttctcgg
     4201 cgccgacgcg gcgggtggcc gggacgcgga tgttctcgta gtagctggcg gtggtgtcgt
     4261 gcgaggcgag ggtcctgatg agggtggcgg agtagccggg gtcgtcggtc gggacgagca
     4321 ggatgctgat gcccttgtgg ggtttggcct ccgggtcggt gcggaccgcg agccagaccc
     4381 agtcggcggt gtcgccgttg gtcgtccagg tcttctgacc gttgatgatg tagtcgtcgc
     4441 cgtcgcgcac cgcgcgggtc ttgagcgagg cgaggtcggt accggcgtcg ggctcgctgt
     4501 agccgatcgc gaagtcgatc tcaccggaga ggaccttggg gaggaagtac cccttctgct
     4561 cctcggtgcc gaaccgcatg atcgtgggcc cgaccgtgtt gagcgccatc agcggcagcg
     4621 gcaccccggc ctgggccgcc tcgtcgaaga agatgaactg ctcgaccggg ccgagcccgc
     4681 gcccgccgta ctcctgtggc cagcccaccc ccagccagcc gtccgagccg agccggcgga
     4741 tggtcgcgcg gtagaaccgc ttctgcccgg tggaatcggc gtagcgggcg taggcgtcgt
     4801 cggggaccag ctcggcgaag tacgcgcgca gctcatcgcg caaccgccgc tgatcagggg
     4861 tgtattcgag gtccacggcc cctcctggag tctcgcgtgc gccgtgacgg cgggctggga
     4921 gcgtcctggg atcgaggggc acggtagaac gtgttccaac aatacggaag ggccgtggac
     4981 cgggcccgtc gacccggtcc acggcccggg cctcagccct ccacccgggg cgggctgtcg
     5041 tcggagccgc gccgcaccac ctgtaccggc cggccggggc gccaggtccg cagcaccatc
     5101 tccccgttct ccgaggccgt gtgcaccacc tcggtcacct cggtgcggaa gaggtggaag
     5161 ggctcgggcg gccggaccgc ctcggcgaag cgggcgaccg cctcggggtc ggtcacctcg
     5221 accgcccggc cgctcacccg tacgtctccc tcggtcagcc cgtcccccgg gccggggttg
     5281 gcctgcaccg agaaccgcgg atcgcggcgc agatccagcg ccttgcgcga gtccggcatc
     5341 atgcccagcc acaactcacc ggagaggaag gtcacttcga gcggggtcac ccgcggggag
     5401 ccgtcctggc ggagggtggc gagcacatgg tggcggtagc gccggaagcg gtcctgggcg
     5461 tagccggcga aggtgggctc ggccgcctcg aatccggccc agctggtggt cgggtaggtc
     5521 gtcgtcatgg cgcccatgct cgcgccgttt ccggacgtct cctgtcggga tttcgcggct
     5581 tccgactccc gcgcctggtc cgggggcaga tacgcgttcc actcggtgcc cggcagcgga
     5641 tagcccaccc aggtgcgggc gtaggacggg ggccgggcct ggccgcgccg cagcagcagc
     5701 gcggtgggtt cacgggcggc gcgccgcagc agcgagggca gggtggtgga ccggttgttc
     5761 ccgctggtct gggcggagga gcagcccgcg tggtacgcga tgggcagggc gcggtcgccg
     5821 gtcaccagac agggcggccg cagccccagc cgctgaagcc cctgcgcggc ggtgcggtag
     5881 cgcccggtgg tggtgtcgga ctgcttcgcg gtgtggtcga ggatgacgaa ctggctggcc
     5941 agatggagcg tgacgatcac cccgagggcc accgccagat gctgcggtga gcgcgcggcc
     6001 cgtacggcgc ggaacaccag cccggcgatc ggcagcgcca gcagggcgta ggagggcatc
     6061 aggaagcggg gtgcggagta gtcgatgagc agcagatagg gcagggcgag tgcggccgcg
     6121 cagacgatgg gcagcagggt cagcggcacg gcggggggcc gggcggccgg gcggccgagg
     6181 cccacccgca cccggcgcag ctcctggcgg tcgcgcaggg cggcgtgtac ggcgaggagg
     6241 gtcagcacgg gcagcgccag ccaccacacg gtcagctccg ggtggcgcag cggcacctcg
     6301 caggggcggc acagctgggg tccgttgagg ctgcgcagcg cggcgcccac gctgaagtgg
     6361 agccccatac ctccctcgac atggctggag acgttcagcc gccccccgat gccgccgaag
     6421 cggtcgtacg cctcgccgat ccactgggcg gcgccgagca gcggcccgcc gatcagcgcg
     6481 ggcagggcgg ggcgccaggt gcgcaccccg atggcgccga tcagcagcgg cagggcgagc
     6541 catcccccgt cgggggtgcg caccagggtg acgcccgcga ggacggcggc cagccaccag
     6601 cgggcgttgg gctcgtccgg tgcccggagg aaccagccga cggcggcgac ggcgccgatg
     6661 gccacccaga ggttgggcat caccgcggga ccgctgatct gggtgatcca cagcccggag
     6721 aagagcagcg cggccagggc gacctggggt gggggcagca gccgggccca gacccggaag
     6781 gcgccgtaga gcgcgcccgc ggacagcagc atgagcagga cgcgcagcac cggaatggag
     6841 tcggtcgcgg cgaccacggg cgcgaccagg agactgacgc cgcgcgagcg gggtgcgctg
     6901 aagtacgcgg gcggggtgcg cggatcgacc tgggagacgt acacggactc gtcccagccc
     6961 agcgcgtgac cggtgtgcgg gatcaccatg gcgagctgga ccacggcgta tccgatggcg
     7021 accaggccga gccagggggc cggtcgacgg taccgccgcg gctggcgggg ctgggggcgc
     7081 gggggcagca cggcggccgc cggtgcggca gtattctcca tgcgcgcacc atatgatgac
     7141 tatgtacctt tttcgtccta ttaggccatt cggctcagtg tccaaggggt gccattgacg
     7201 tgacggatcc gtaggctgtt gcagcggtgc acagccccca tccggcggag gacggacaca
     7261 cctatgaaaa tgctcatcaa cgtccccgag accgtggtcg ccgacgcgct gcgcggactg
     7321 gccgcctgcc accccgagct gaccgtcgac atcgaaaacc gggtgatcgt ccggcgggac
     7381 gcgccggtcg agggcaaggt ggcgctgatc tccggtggcg ggtcgggaca cgaaccgctg
     7441 cacggcggtt tcgtggggcc cggcatgctc gacgccgcct gtcccggcga ggtgttcacc
     7501 tcccccgtac cggatcagat ggtgcgcgcg gcggccgcgg tggacagcgg caagggcgtg
     7561 ctgttcatcg tcaagaacta cacgggcgac gtgctcaact tcgacatggc cgccgagctc
     7621 gccgaggacg agggcatcca ggtcgccaag gtcctggtca acgatgacgc ggcggtcacc
     7681 gacagcctct acacggccgg ccggcgcggc accggcgcca ccctgttcgt ggagaagatc
     7741 gcgggcgcgg cggccgaaga gggcgcgccg ctggagcggg tggagtcgat cgcccggcgg
     7801 gtgaacgagg tctcgcggag cttcggcgtc gcgctcagcg cctgctccac cccggccaag
     7861 ggcggcccca ccttcgatct gcccgccggg gagctggagt tgggcgtggg catccacggc
     7921 gagccggggc gtgagcggcg ggcgatgatg acctcccgcg agatcgccga ctacgcggtg
     7981 gaggtggtgg tcgaggacct gcgcccggac aatccggtgc tgctgctggt caacggcatg
     8041 ggggcgaccc cgcagctgga gctgtacggc ttcgccgccg aggtgcaccg ggcgctcggc
     8101 gagcggcagg tggcggtggc gcgtacgctc gtcggcaact acgtcacatc actcgacatg
     8161 gcgggcgcct cgatcacgtt gtgccaggtc gacgaggacc tcctgcggct gtgggacgcg
     8221 cccgtgcgga ccgcagggct gcgctggggc gcctgaggcc gggcggccca cgatacgtac
     8281 gctgtcgccg ttggctactc cccgaggagg cgtctgtgtc cagcagtgaa cccgccgtcg
     8341 acgacgtgct cgacacccct ttcttcctcc gatggctcac ggccgcggcc gcggccgtga
     8401 gccgtgaggc ggcccgtctc accgatctgg actccgcgat cggcgacgcc gatcacggca
     8461 ccaacatgca gcgcggcttc gccgccgtgg ccgaggccct ggagaaggag cccccgggct
     8521 cgcccggggc cacgctcatc ctggccgggc gccagctgat ctccaaggtg ggcggggcct
     8581 ccggaccgct gtacggcacg ctgctgcggc gcgcgggcaa ggcgctcggc gacgccgagc
     8641 ggatcacccc gcagcagctg gcggacgcgc tgcgggccgg ggtggacgcg gtggcgcagc
     8701 tcggcggtgc cgcgcccggc gacaagacga tgctggacgc gctgctcccc gccgtcgagg
     8761 cgctgggcac gggcgccggg tcgttcgcgg ccgcgggcga ggccgccgag aagggggcgc
     8821 tggccaccgt gccgatgctg gcccgcaagg gccgggccag ctatctgggt gagcgcagcg
     8881 tcggccatca ggacccgggc gccacctcgt cggcgctgct catcgcggcg ctcgcggagg
     8941 cggcgcgatg accgacgagg gcgagaagaa gctggtcggc atagtcctgg tgtcgcacag
     9001 cgcggcggtg gccgactcgg tggccgagat ggcgaagggg ctgtccggcg gtggcaccgc
     9061 gccggtgcgc gccgcgggcg gcaccgagga cggcgggttc ggcaccagtc ccgagctcat
     9121 agcggaggcg gcccacgcgg tcgaccgggg cgcgggagtg gcggtcctgg tggacctggg
     9181 cagcgcggtc ctggccgtca aggcgctgct ggccgagggc gacgaactgc cggagggcac
     9241 ccggttggtg gacgcgccgc tcgtggaggg cgcggtcgcg gcgctcgtca ccgcctccac
     9301 cggggcggat gtggaggcgg tgctccaggc ggcctcggag gcgtacgact accgcaaggt
     9361 gtgatagcga cgcgctattg aacgggcccc gccgagtgaa ggcgaggccc gttcagcttt
     9421 caacgaagtc accgcgcgca tattgcgcgg ccgcgtattt ccctgatact cggcgcgtac
     9481 ggggcgagtt gcccggtttc ggaccgcacc gggcacggcg acagcacccc ggacccccgc
     9541 ccgccaagtg ataggcgcga tagcagaacg ggcttccgaa tccgtcgatc ttgcgtctag
     9601 actgctcatg tccgagtggg gggaccggcg gcactcaggg ggaataagtg gacgtaattg
     9661 agtgtgcccg cgcgcacctg gcatccatcg aaacgatgat gtccacgcgg gtgccgcgcc
     9721 cgccgggacc ccattgccgc ccggcccgga ttccatgcgc ggaaatgacc cgaccgcgcc
     9781 tgccccatgg ctccctgagc gtctgaacta cgcgcgcccg tcgcggcgcg ttcggcactt
     9841 cggccatggg gcggcggtag cgccccgcgt ccgccttcat ggtgccgcac tcagcacgat
     9901 cggcaatcca tcttttccat acaaagcagg ggtttccgcg ttcctgtttt ttctcgttaa
     9961 tcaacggatt tcgacatttc gacgtggagg agtcagtcgc atgaccacac ccacgctcag
    10021 ccccggccgc ttggatgcgg ataccgtccg tgagtcggtg gacgtcgtac tcgaagactt
    10081 tctggcggcc aaggcccgca ccacaccgca acaccatctg ccgtatctct ccgggctgct
    10141 ccgggatttc ctgtccggcg gaaaacgcat acgccccctg ttgtgtgtca ccggctggca
    10201 ggccgtcggc aacggggagg acaccgaggc ggtgttccgg gtggccgcct gcctggagat
    10261 gttccacgcc ttcgcgctga tccacgacga cgtcatggac gacagcgaca cccgccgcgg
    10321 ccggccgacc atccatcgca ccctggccgc gctgtgcgcc gccgaccgca ggcccgatca
    10381 gatcgagcgg ttcggggtcg gcggggcggt gctgctcggc gacctcgcac tcacctggtc
    10441 ggatgagctc ctgcactcgg ccggcctcac ccccgcccag ttcaacgccg tactgccgct
    10501 gctgtcggag atgcgcaccg aggtgatgct gggccagtac ctcgatctcc aggccaccgg
    10561 ggagctgacc gacgacatcg aggccaccct caccgtcatc cggtacaaga ccgccaagta
    10621 caccatcgag cgtccgctgc acgtcggagc cgccatcgcg ggcgccggcc cggacgccat
    10681 ggaggcgatc agcgcctacg ccctgccgct gggcgaggcg ttccagctgc gcgacgatct
    10741 gctgggcgtg tacggcgatc cggagtcgac cggcaagtcc cagctggacg atctgcgggc
    10801 cgggaagaac accaccctga tcgcgctcgc cctgcgcggc tccgacagcg tccaggcggc
    10861 gcggctgcgc agcctcatcg gcaatccgct gctggacgag cgggacgccg cgaccgttca
    10921 ggagatcttc gccgccacca ccgcccggga ggccgtcgag cagatgatcg acgaccgccg
    10981 gacgcaggcc ctgcgggccc tcgacgacgc cccattcacc gcggacgcgg tccacgcgct
    11041 caagcagatc gcccgcatgg ccactgtgag gaactcatga cgaccggacc ttccacggcc
    11101 ggggcccagg acatcagccg gaccagcgtc cgcccgtacc tggaggagtg cacccgccgc
    11161 ttccaggaga tgttcgaccg ctatgtcgtc acccggccca ccaaggtcga attgaccgac
    11221 gccgaactgc gcgaggtcat agacgactgc aacgcggcgg tggcccccct cggcaaatcg
    11281 gtttccgatg agcgctggat ctcctatgtg ggggtggtgc tctggtccca gagcccccgc
    11341 catatcaagg acatggaggc gttcaaggcc gtctgcgtcc tgaactgcgt gaccttcgta
    11401 tgggacgaca tggatcccgc gctgcacgac ttcgatctct tcctgcccca gctgcgcaag
    11461 atctgcgaga agtactacgg ccccgaggac gcggaggtcg cgtacgaggc ggcgcgcgcc
    11521 ttcgtcacca gcgatcacat gttccgcgac tcacccatca aggcggcgct gtgcaccacg
    11581 tccccggagc agtatttccg tttccgggtc acggacatcg gtgtcgactt ctggatgaag
    11641 atgtcgtatc cgatctaccg gcatccggag ttcaccgaac acgccaagac aagcctggcc
    11701 gcacggatga ccacccgcgg actcaccatc gtcaacgact tctactccta tgaccgcgag
    11761 gtctccctgg ggcagatcac caactgtttc cggctctgcg atgtgagcga cgagacggcg
    11821 ttcaaggagt tcttccaggc ccgcctcgac gacatgatcg aggacatcga gtgcatcaag
    11881 gcgttcgacc agctgacgca ggacgtcttc ctcgatctga tctacggcaa cttcgtctgg
    11941 accaccagca acaagcgcta caagacggcc gtcaacgacg tcaactcccg catccggtga
    12001 gggaacgggg aaccgtgact cccgcgaaga gctccgcaca gccggagcgc tcctggacca
    12061 ccggcacggc gcccggttcg gtgccgctgc tggggcacac cctggcgctc tggcgccaac
    12121 cgctccagtt cctggcctcc ctgcccgccc acggcgatct ggtggaggtc aggctggggc
    12181 ccagccgcgc ctatctggtc tgccatccgg agctggtgcg ccatgtgctg ctcaaccccc
    12241 gtacgttcga caagggcggg gtcttcgaca aggcgcggca gttgctcggg aacagcctct
    12301 cggtctcccg gggcgaggaa caccgctccc agcgacggat gatccagccc gcgttccaca
    12361 ccccgaagat ctccgcctac accgccgcgg tcgccgatga cacccgcgcc gcgatcggct
    12421 cctgggagcc ggggcggacc ctggacatca gcgacaccat gcacgccctg ctgatgcggg
    12481 tcgccgcgcg gaccctgttc tccaccggga tcgacgaggc gacgatcgac gaggcgcgcc
    12541 actgtctgcg caccgtctcg gacggcatct acaagcgcac catggcgccc ttggggatca
    12601 tggagaagct cccgacgccg ggcaaccggc gctacgaccg ggccaacgcc cggctgcggc
    12661 agatcgtgga cgagatgatc cgcgaccggc ggcgctccgg caccgaccac ggcgatctgc
    12721 tctccacgct gctgcgcgcc gaacaccccg agaccgggaa gggattggac gacggcgagg
    12781 tcctggacca ggtggtcacc ttcctggtcg ccgggagcga gaccaccgcc tccaccctcg
    12841 ccttcgtctt ccatctcctg ggtgcccacc cggaggtgga gaagcgggtg cacgccgaga
    12901 tcgacgaggt cctcgagggt cgcgtcgcca ccttcgagga cctgccgtcc ctggagtaca
    12961 cccgcggggt catcaccgag tcgctgcggc tgtacccgcc gtcctggatg gccatgcggg
    13021 tcacggcggc cgagaccgaa ctcggcggcc ggaccatccc ggcgggcacg atgatcctct
    13081 acagcgccca ggcgctgcac cacaaccccg aactgttccc cgaccccgag cggttcgacc
    13141 ccgagcgctg gctccccggc cgcgccgagg aggtgccgcg cggggcgctg ctcccgttcg
    13201 gcgcgggcag ccacaagtgc atcggggacg tcctggcgct gaccgagacc gccctcatcg
    13261 tggcgacgat cgcgagccgg tggcgtcttc gcccggtgcc cgggaccacc ttgcgccccg
    13321 agccgaaggc gacgctcgaa cccggcccgc tgcccatggt gtgcgagccg cgctgacacc
    13381 gtccggtccg ggggccgccc cggaccggac gccccgtacc ttccgtaccc cacctcgcga
    13441 atgaaggaca tcttccgcat gaggaccgcg cagcacccgg cgacgcgcca ctggcggcac
    13501 gccctcgccc ctggcgggct tccactggcc ggccatgccc tgctcatggg ccgcaagccg
    13561 cttcagttcc tggcctccct gcccgcccac ggcgatctgg tcgagctccg gctggggccc
    13621 cggcccgtct ttctgccctg tcatccggag ctggtccagc aggtgctggt gaacgcgcgg
    13681 atctacgaca ccggcggacc ggtgaaggag aaggcgaagc ccatcctggg caatggcctg
    13741 atcacctccg actgggcgga ccaccgccgg cagcgccggc tggtgcagcc cgccttccag
    13801 gccgcccgga tcgccaagta cgccgaggtg atggaggagg agtgcgcggc cgagtcgacg
    13861 gcgtggtcgg cgcggcggcc catcgacgtc agccatgaga tgctcgcgct caccgcgcgg
    13921 gtgacggccc gtgcgctctt ctcgaccgat atggcgccgc acgccgtggc cgagatccag
    13981 cactgtctgc ccatcgtcgt ggagggcgcc taccggcagg cgatcgaccc caccgggctg
    14041 ctggccaggc ttccgctcgc ggcgaaccgg cgcttcgacg acgcgctcca ccggctcaac
    14101 cagctcatcg accgcatgat cgacgactac aaggcggcgg acgacggcga ccgcggcgat
    14161 gtgctctccg ccctcttcgc cgcacaggac gacgagaccg gcggcacgat gtcggaccag
    14221 gagatccacg accaggtcat gaccctgctg ctggccggga tcgagaccac cgcctccgcg
    14281 ctgacctgga cctggttcct gctcggccgc aacccccggg ccgaggccgc gctgcacgcc
    14341 gaggtggacg aggtgctggg cgggcgggcc ccggtctacg ccgacgtccc ccggctcgcc
    14401 cacacccagc gggtgttcag cgaggcgctg cggctcttcc cgcccgcgtg gctcttcacc
    14461 cggaccacca ccgaggccac cgagctcggc gggcggcggc tgccccccgg gtcggacgtg
    14521 ctgatcagcc cgtatgtgat gcaccgcgat ccggccctgt tccccgaccc ggagtccttc
    14581 gaccccgacc gatggctccc cgagcgggcc aaggacgtgg cacggaactc atatctgccg
    14641 ttcggcggcg gcagccgcaa gtgcatcggc gacgtcttcg gcatgacgga ggcgacgctc
    14701 gccctggccg cgatcgcggg ccgctggcgg atgcgcccga ttccggggac gaagatccgg
    14761 ccgaggccgc agatgagcct caccgccggt cccctgcgga tgattccgga accacgctga
    14821 ccgccctgcc ccacggaccg cggtggtcgg ccaccgcggt ccgtcgagtc cgtcgggcag
    14881 ccggggtccg ccggaccgcc ggagtccgcc gggttgcagg agtccatcag gttgccggga
    14941 tccgtcgagg tgccggggtc caccggaccg ccggggtctg tcgggcgggc acggccgcgg
    15001 ccagccaggg cgcacgtccc gtgggcgggg actcaggcgt ccggggcggt ggagaaacgt
    15061 accggcaggc gccgcaggcc gcgcagcatc aggctgggcc gccaggcgag ttcggccgga
    15121 tcgccgtcca gggcgagatc ggggcagcgc tccagcaggg cccggaaggc gacggcccct
    15181 tcgagacggg ccagcggggc gcccaggcag tggtgcacac cgtgcccgaa ggcgagatgg
    15241 ccgcgcgacg agcgccggat gtcgaaacgg tccggttcgg cgaagcgccg ggggtcacgc
    15301 gacccggcgg ccagggcgac cgcgaccggc tccccggccg cgatggccgt accagcgatc
    15361 tccaccggct cccgggtgaa gcggaacgcg gcgctctcca ccgggccgtc gtagcgcagc
    15421 atctcctcga tcgcgccctc cagcagcgac cagtcggcgc gcagcgcggc cagttgcccg
    15481 gggtggcgga gcagggcgag ggtgccgctg gagatcaggt tggcggaggt ctcgtagccg
    15541 gcgaccagca gcacgaacgt catgccgagc atctcctcgg cggagagcgc gtcgccgtcc
    15601 ccctccatcg tgcggaccag ggcgctgagc agctcgtcgc ccggggctct gcgcttggac
    15661 tcgataagct ccgcgaagta acccgtcagg gcctgggcgg cggcacctgc ggtctccggg
    15721 caggtcaggt cggtgctctc cagataccag tcgtggaacg ccttacggtc cgtctccggc
    15781 acccccagca gctcgcagat gacggccagg ggcagcggca gcgcgtagtc ctcgacgaga
    15841 tccgcgcggc ccagcgggac catggcgtcc aggagttcgt ccgcgatccg ctggacgcgg
    15901 gggcgcaggg cctcgatccg ccccggggtg aacgtgcggg ccaccagccc ccgcagccgg
    15961 gtgtggtgcg gcgggtcggt ctgcaccatg ttccgtccga tggcattgcc gccgtcgtcc
    16021 tgccacgcgg ccgagtgacg tacgtcattg ctcagccggg gatcggtcag cgcggcgcgg
    16081 gcctcttcat ggccgacgac gagccagaac acaccggagg tgtccgtgcg cacccggtgg
    16141 accgggcccc gttcccgcag acgtgcatag accggatacg ggttgacgac gaaatccgcg
    16201 ccgagcgcgg acagatcctg gggcatgtga tcccctcagt cggttgacgg cttcccccga
    16261 agccagaacc ggggatcgtt ccccgctctg tcgatgatct taacacctaa ccggagagat
    16321 tcccccggtt agtgttaggg ttgcgggcca tgggcagccg tgtggagaaa gagacaccat
    16381 tgcgccgaga cgcgcggcgc aatcgcgaga tgctgataac cgccgcccgg gagatctaca
    16441 cggatcaggg ggtggacgcc ccgctcgacg acatcgcccg tcgggccgga gtcggcagcg
    16501 ccaccctcta ccggcggttc gccggccggg cggaactcat cgaggcggtt ttcggcgatt
    16561 ccctcaggga cattctgcgg gcagcggagg aggcccgctc ggcggtcgac gcctgggtcg
    16621 gtctgacggc ctatctcgag cgcatcttcg ggctgctcgc cgccgaccgg ggcaccaacg
    16681 atctgatgac caccggtata cagggcgtcc cctcgctcga cgcgctccgt gaggagaacg
    16741 cgaagacact cgacgtcctc ctgcgccgcg cccaggaaca gggcgcggtc cggaaggacg
    16801 ccaccgcgga ggaccttcag ttcatgctgg ccgcactcgg ccgcgcggtc cccggctcga
    16861 cggtcgccgc gccactggcc tggcgccgct atctgttcct gctgctggac gggttgcgcc
    16921 ccgaggggtc ccatccgctc ccggccccct cgctcaccac ggagcagctc aacgccgcca
    16981 tgctccagct cggcaaggta cggcggccgc gcgcggggcg cgccgactag gcagagtccg
    17041 ggagcacctg ctctccggga gcgcccccct gttccggaag cgccgactct ccgggagcgc
    17101 gggccggagg acgtcgtccg gggcgcgccg atgtggaggc accggggcgg gggtccgggc
    17161 gaggcacctc accacagtgg ccgggcgaag tatgtcgccc gcctacatat ccgagccgaa
    17221 gagcgcattt ctacggtgtg gcaacacaaa accgtacccg caccccgctc ggaagtggtg
    17281 acccatgccc accccggatt ccccggcctc cgctcccccg accccgcccg gttcgctgcg
    17341 ccgtatcgtc gccgcgagcc tcatcggcac caccatcgag tggtacgact tcttcctcta
    17401 cggctcggcc gccgcgctcg tcttcaacaa gctcttcttc ccggactccg atccgctggt
    17461 cggcacgctg ctctcgttcc tgacgtacgc ggtcggcttc gccgcccggc cggtcggcgc
    17521 cctggtcttc ggccactacg gcgaccggct cggccgtaag aagctgctga tcctgagtct
    17581 gctgatgatg ggcggcgcga cctgcgccat cgggctgctg cccacccacg ccacggtcgg
    17641 ttcggcggca cccgtactgc tcaccgcgct gcgtctgctc caggggttcg cgctgggcgg
    17701 cgaatggggc ggggcggtgc tgctggtgtc ggaacacggg gacgcgcggc ggcgcgggtt
    17761 ctgggcgtcc tggccgcaga ccggcgcccc cgcggggcag ctgctggcca ccggggtgct
    17821 ctccgcgctg accgccctgc tctccgacag cgccttcgag tcatggggat ggcgggtgcc
    17881 gttcctgctc tcgggcgtgc tggtggtagt cggcttgtgg attcgtctct ctgtcgatga
    17941 atcgccggtg ttcaaggcgg cgctggcccg ggccgaggcc cgtaaggcgg ccacggacgg
    18001 cggtgcggac gccgccgaga agatgccgct ggtggccgtc ctgcgccacc actggcggga
    18061 tgtgctgatc gccatgggcg cgcggatggc cgagaacatc agttactacg tcatcaccgc
    18121 cttcgtcctc gtctacgcga cctccgacca tgtgggcctc ggcaagcaga ccgcgctcaa
    18181 cgccgtactg atcgcctcgg ccgtgcactt cgcggtcatc ccggcctggg gcgcgctgtc
    18241 ggaccggatc gggcgccgcc cggtgtatct cctgggcgcg gcgggtgtgg gcgcatgggc
    18301 cttccccttc ttcctcctca tcgacaccaa gggcttcccg gccctgctgc tcgccgtgac
    18361 ggtcgggctg atcttccatg gggcgatgta cgcgccccag gcggcgttct tctccgagat
    18421 gttcgcgacc cggatgcggt attcgggggc gtcgatcggg gcgcagttct cgtccgtcgc
    18481 ggccggtgcg cccgccccgc tgatcgccac cgcgctcctg gccgactacg acagcgccac
    18541 cccgatcgcc ctctatgtga tcgcggcggc cctgctcacc ctggtggccg tgggcgtcgc
    18601 caaggagacc cgggaccgcg atctggccgc cgtggaaccg acctcggccc actccccgcg
    18661 tccggcgtcg gagggtgcgg ggcgcaaggc ccgttcggcc tcggctcagt agcccacggc
    18721 cgaggccagt cggtgcagcc gcagggcgag ctggatctcc agggagcggg cgggcgactg
    18781 ccagtcgggg ccgagcagcc gcccgatccg ctccagccgc tgcgccaccg tgttgacgtg
    18841 cacgtggagg gcgtccttcg tacgggccgg gctcatccca ccggcgaagt acgcgtcgag
    18901 cgtgcggatc agttcggtgc cgcgccgctc gtcgtagtcg atgaccgcgc ccacggtgcg
    18961 ctgcacgaag tcctggacgc cggtgccggc cggggcgccc tcgcgggtac cggccagcag
    19021 cagaccgagg aagccgaagt cctcggcggc ggcgccctgt ccggcccggt ccagcacccg
    19081 cagggcggcc agacagcgcc gcgcctcggc atagcccgcg gcgacgtccc cgggccgcgc
    19141 ggcgggcgcg gggacaggcg cggaggcgcc gacggtgacc gcggcgtgca cggcggtgcc
    19201 cagctggcgg gcggtgcggc gggcgagggc gtcggcggtg tcgccctcgg ccagcggcag
    19261 cagcagaacg gtgccgccgt cgcgggcggc ggccagaccg tgtcgggtga ccgccagatg
    19321 ggacgcggcg gaccacagcc gacggcggcc cgcggcgtcc tcggcggggg cgccaccggg
    19381 accgcctccg ggcccggctc ccggtgcgcc gccgggcctg cttccggatg ccccgccggg
    19441 accgctcgcg cgtgcgccgc cgggaccgct cgcgggcgcg gtgccgggtc cgcctccggg
    19501 ggtggtgccc ggcccgcttc cgggtgcccc gccggggccg gcggcgggcg tgccggtgtc
    19561 cggggcctcg atgcccgcgg cgagcaccac atggggcgtg tccaggtccg cccggagccg
    19621 cgcggcgcgc tcgcgcagca gccggggctc acggtcggga gcgtcgagca ggtcgtccag
    19681 gagctcaccg cgcacccgct gctcggcctc acccgccgag cggcgggcga gctgcaacag
    19741 cgaggtgacc atggcggcgc gctccagggt gcgctggtcc atggggtcga gccgggggtg
    19801 gccgcgcagt acgagcgcgc cgagcagttc gccacccgcc gagacggcgg cgacccagtc
    19861 ctcctcgccg tcgcgcaccg cgtggccatc ggcccgggac cggtcgacgg ccgccgcggg
    19921 cgcctcgtcg gtctcgagga actccacgga gccgctgagc acctcggcca gcgcgtccgc
    19981 cacgtcgtgc accccgccac cgcgcagcac cagctcggtg agccggtcat ggacgtcgga
    20041 ggcgcgctcg atgacccggc tgcggtcccg gatgatctcg ttggccgcct ccagttcggc
    20101 gagcgccgta cgggtctcgg cgagcagatg ggcggtgtcg atggccacgg ccgcgtgggc
    20161 ggcgaacgag ccgagcagcg cgatctgctc gcgttcgaac acccgggccc tgcggtcggc
    20221 cgcgaacagc acgccgatga caccgctgcc cagcagcagc ggcaccccga ggatggcgac
    20281 gagcccctcg tccctgacgc ccgcgtcgat ggcgtgcgtg tgctggaacc gcggatcgtc
    20341 gaagtagttc tcggtcacat aggggcgggc ggtctgggcc accagaccgc cgagcccctc
    20401 ccccatgccg agccgcaact gctggaagcg ggccgagacc gaaccgtcgg tgaccctcat
    20461 ataggtgtca ccggccgtcg gatcgttgag cgtcagatac gcgacctcgg tgcccagcag
    20521 ggagcgggcg cgctggacga tggcctggag caccgcgtcc agatcgcgca gccccgccag
    20581 atcgtgggcg gtctcgaaga gcgcggagag ctcggcctcg cggcgccgtc gcccctccag
    20641 ctcaccgcgc acccgcaggg cgagcagctt ggcgcgctcc agagccgcca gcaggtcggc
    20701 cggggccttg tcggcgcggg cgcgcagcac cgggcgctcg tacgcctcgg cgggcgcgcc
    20761 gcgtacgagc agttccaggt agggggcctc cggccggtcg tcgggcatgg tcacaggcat
    20821 actcccgccg gacgcggcgg cgccagccgt agggcggccc ggtgtccttt cgagggggcg
    20881 gccgggcaag aggcggtccg gtggctgagc caatgagcca ccattccgcc cgtccggcag
    20941 tggctgagcc actgagccgc tctcccgccc ctccggcagt ggctgagcca atcggccacc
    21001 gtccgccggt ggctcagcca atcggccttc ctggcccagt ggctcggcca atcggccttc
    21061 accggccgat gaacgatccg atgagccgct cagtgggcgg tccatccgcc gtccatgctg
    21121 agcgaggcac cggtgacgaa ggacgtatgc ggaccgcaga gatacgcgac ggcctcggcg
    21181 acctcctcgg gttcgaccag ccgcttgacc gccgaatcgg ccagcatcac atcggagacc
    21241 acccgctccg gcgagatccc gtgggcctcg gcctggtcgg cgatctgccg ctcgacgagc
    21301 ggggtgcgca catagccggg gttgacgcaa ttggaggtca ccccgtgcgc cgcgccctcc
    21361 agggcggcga ccttggacag cccctccaga ccgtgtttgg cggccacata ggccgatttg
    21421 tagggggagg cgcgcagccc gtgcaccgag gagatgttca cgatccggcc ccagccccgc
    21481 gcgtacatat gcggcagcgc gccgcgcacc agccggaacg gtgcctcgag catcacggtg
    21541 agcacccggg agaacacctc gggcggaaag tcctcgatgg gccggacgag ttggagcccg
    21601 gcgttgttga ccaggatgtc gatgccggcg gcggcccgtt cggcggcgtc gaggtcggtg
    21661 aggtccaggg ggtgggcctc gacctggccg ggcagtccgg cggccgcgtc gaccaggtcg
    21721 gtgaggccct cggcgtccag gtcgacggcc cgcacccgcg ccccggcggt ggccagccgc
    21781 agtgtgcagg cccggccgat gcccccggcg gcgcccgtga cgagtgcggt acggcaggac
    21841 agatcggggc cgtcggacgg ccgggggccc gggcccggtg tggtggacgc gctcatgagt
    21901 ggcacattag gcagccatcg tgcccggacc gatgtgcggg cggcacatac ttcactccgc
    21961 gacgatgggc tcgaaccatg tcgggccgtc ctcgagcgcc
//
