LOCUS       NZ_LJSN01000003        22535 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces noursei strain JCM 4701 scaffold3, whole genome shotgun
            sequence.
ACCESSION   NZ_LJSN01000003
VERSION     NZ_LJSN01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 3830602)
  AUTHORS   Graham,D.E., Mahan,K.M., Klingeman,D.M., Fida,T., Giannone,R.J.,
            Hettich,R.L., Parry,R.J. and Spain,J.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-SEP-2015) Biosciences Division, Oak Ridge National
            Laboratory, PO Box 2008, MS-6038, Oak Ridge, TN 37831-6038, USA
REFERENCE   2  (bases 1 to 3830602)
  AUTHORS   Graham,D.E., Mahan,K.M., Klingeman,D.M., Fida,T., Giannone,R.J.,
            Hettich,R.L., Parry,R.J. and Spain,J.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-SEP-2015) Biosciences Division, Oak Ridge National
            Laboratory, PO Box 2008, MS-6038, Oak Ridge, TN 37831-6038, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2015
            Assembly Method :: SPAdes v. 3.6; SMRT Analysis v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: Illumina MiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002891315.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 20:38:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,947
            CDSs (total)                      :: 8,851
            Genes (coding)                    :: 8,489
            CDSs (with protein)               :: 8,489
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 362
            CDSs (without protein)            :: 362
            Pseudo Genes (ambiguous residues) :: 0 of 362
            Pseudo Genes (frameshifted)       :: 118 of 362
            Pseudo Genes (incomplete)         :: 301 of 362
            Pseudo Genes (internal stop)      :: 23 of 362
            Pseudo Genes (multiple problems)  :: 74 of 362
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:29:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1780834
            Orig. end                         :: 1803369
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LJSN01000003.1.
            Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22535
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="13"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22535
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22535
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12535](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12535)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    85..105
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.3"
                     /tool="antismash"
     gene            606..1118
                     /locus_tag="AOB60_RS29515"
                     /old_locus_tag="AOB60_28445"
     CDS             606..1118
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1278: PadR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538119.1"
                     /locus_tag="AOB60_RS29515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28445"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_073449300.1"
                     /transl_table=11
                     /translation="MLELAILGFLAEGPLHGYQLRHRIAHLSGHARPVSDGSLYPAINR
                     LVRAGLLDRRTEPGTSAAQRHTLSLTDTGRRELVRRLRDANGLDITDSTRYFTVLAFLS
                     QLPDTTDQHAVLRRRLEFLEQPASFFHDGDRPLRTDDTDDPYRRGMLTIARATSRAERS
                     WLREVLA"
     gene            complement(1131..2138)
                     /locus_tag="AOB60_RS29520"
                     /old_locus_tag="AOB60_28450"
     CDS             complement(1131..2138)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012656.4"
                     /locus_tag="AOB60_RS29520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28450"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_102925564.1"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.3e-14, bitscore:
                     52.2, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIESCAESVAEPLSEHAADALPPLDTAPTALVALARDAGYRGTA
                     APLAETLLVARPLLAAAGLAVPDGQLTVAAGPLDVRFAHVDTDSRVGPSGAAGTDDALR
                     VSGTLHRVPWARAVEAAVVLTEGPGGGPVLFLLEATEWRQVAGTNLAGEPRDDLVLLDV
                     AVPAERVRRVPAALVREATWRSGLARAALIAGAARRCVELTVDHTSSRVQFGRPLSHFQ
                     AVKQEEAKLVEEAALVAAAVEAAASALSEPDSAEFTAWLAAAQAAASVAEITRIAHQLH
                     GAIGFTELSPLRLATTRMWSWRDEDGGERAWQQRIGRHVLDGGSGGLWQQVTGG"
     gene            complement(2135..3301)
                     /locus_tag="AOB60_RS29525"
                     /old_locus_tag="AOB60_28455"
     CDS             complement(2135..3301)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571525.1"
                     /locus_tag="AOB60_RS29525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28455"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_102925565.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.3e-22, bitscore:
                     77.4, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 6.2e-20, bitscore:
                     68.8, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.3e-08, bitscore:
                     31.5, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLSDLDLGAVQLPPEATRLRQEVRDFLAAERAAGTVLGRPDSWL
                     TGWDPAFTRRLARRGWVGMTLPRAYGGGGRSNLERYVVIEELLAAGAPVSAHWVADRQA
                     GPTILRHGTEAQRSHFLPRIAAGACFFSIGMSEQDSGSDLASVRTRAERTANGWRLTGT
                     KMWTGGAHVNDHAIVLARTDESEDRHAGLSQFIVDLRDPHVRVEPIRLLSGEHTFNYCH
                     LEGVELTDEALLGRPGDGWRQVTGELALERSGPERFLSTLPLLSALVGQLQRTGACSPE
                     QQARVGRLTARLASIRQLSLGVAAALAAGRPADVQAALVKDLGTRFEGELVNEVREILP
                     IAARFDATRGSYPELLATAILHAPGYTLRGGTNEILRGIITRGLELSR"
     misc_feature    complement(3242..3244)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3397..4224)
                     /locus_tag="AOB60_RS29530"
                     /old_locus_tag="AOB60_28460"
     CDS             complement(3397..4224)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (24-263). E-value: 2.6e-60. Score:
                     195.7. Matches aSDomain:
                     nrpspksdomains_AOB60_RS29530_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571524.1"
                     /locus_tag="AOB60_RS29530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28460"
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_102925566.1"
                     /transl_table=11
                     /translation="MNEQAHLDEQAAPNAWEPLRVEHRPNGVTVLTFDNPDKRNPMTGR
                     LTAQWRRAMRSLRQDPDLRALVITGTGPAFCSGADLGELADRHGQPLSGTRAQLSDFYR
                     TWLTVRDLSVPTVAAVNGHAVGAGLALALACDLRYAAAEAKLGAPFVQLGLHPGMATTA
                     LLAEAVGPSRARELLLTGRLISGARAATIGMVHEALPADQVLRAALDVADEIAAAAPLA
                     VRLTKSGLAQGQPTVERALTWEGLAQPVTTTTDDFREGVQARRERRRPHFTGT"
     aSDomain        complement(3436..4152)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AOB60_RS29530_ECH.1"
                     /evalue="2.60E-60"
                     /label="AOB60_RS29530_ECH.1"
                     /locus_tag="AOB60_RS29530"
                     /protein_end="263"
                     /protein_start="24"
                     /score="195.7"
                     /tool="antismash"
                     /translation="PNGVTVLTFDNPDKRNPMTGRLTAQWRRAMRSLRQDPDLRALVIT
                     GTGPAFCSGADLGELADRHGQPLSGTRAQLSDFYRTWLTVRDLSVPTVAAVNGHAVGAG
                     LALALACDLRYAAAEAKLGAPFVQLGLHPGMATTALLAEAVGPSRARELLLTGRLISGA
                     RAATIGMVHEALPADQVLRAALDVADEIAAAAPLAVRLTKSGLAQGQPTVERALTWEGL
                     AQPVTTTTDDFREGVQA"
     gene            complement(4284..5417)
                     /locus_tag="AOB60_RS29535"
                     /old_locus_tag="AOB60_28465"
     CDS             complement(4284..5417)
                     /EC_number="2.8.3.-"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571523.1"
                     /locus_tag="AOB60_RS29535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28465"
                     /product="CoA transferase"
                     /protein_id="WP_338064008.1"
                     /transl_table=11
                     /translation="MRVVELASVIMGPYAAQQLGDLGADVIKVEPPTGDLTRHYPPTRS
                     PGMGVMTLNLNRNKRSVALDLKAPGGRDALLALLASADVFLTNVRPQALRRLDLAYEDV
                     AAVNSGLVYLNAQGFRSDSPLGGHAAYDDVVQAASGLVWLNEQVSGVPHYVPTVLADKI
                     CGLVIVQSVLAALHHRDRTGQGQHVEVPMADTMLAFNLVEHLAAATLSPPEGPIGYPRA
                     LSPRRTASRTADGWMCILPYSDRNWRDFFAFVGRPELADDPRFASYAARVHHADELYVL
                     VGEFTTRHTNAQWQEFCDATSIPAAPVLSLTEAATSAYAAEGGLLREAEHPTEGGYRLI
                     GQPVRFWATPAGLHRHCPRVGEHTEEVFAEIGHRPPS"
     gene            5587..6501
                     /locus_tag="AOB60_RS29540"
                     /old_locus_tag="AOB60_28470"
     CDS             5587..6501
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571522.1"
                     /locus_tag="AOB60_RS29540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28470"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_073449295.1"
                     /transl_table=11
                     /translation="MELTQRILQQIVVLAEEQHFGRAAERLAMRQPPLSQAIQRLERGL
                     GVTLFDRLPRGARLTPAGRAFAEDARRLLEAQAAAVDRARRIASGHEGELRLGFISSLG
                     YDFLPRLLRRTHAQLPELRLHLGQHPSAELVDMLQAGTLDLALVRLPVTGTERLTVRRI
                     GVERLVAVLPEHHPLVATSRLDLRELAEEWFAVPKPGALPGLAEQVALACAQAGFTPRP
                     RGQADDLPGLLSYVAAGLCLALAPEQVRTLGIPGVVYRPLHGDSPYLESTVAAVHRADG
                     PDAAVQQVLKLIEPDLPTVECTP"
     gene            6706..6924
                     /locus_tag="AOB60_RS48540"
     CDS             6706..6924
                     /GO_function="GO:0004089 - carbonate dehydratase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012696.4"
                     /locus_tag="AOB60_RS48540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbonic anhydrase"
                     /protein_id="WP_219729436.1"
                     /transl_table=11
                     /translation="MAVFITCSDSGVVPTMFTGARPGELFELRVAGNIVPRPRDTCRRR
                     AADRTHDARGTFRPAAASPCERHAVAL"
     misc_feature    6787..6789
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6973..8697)
                     /locus_tag="AOB60_RS29550"
                     /old_locus_tag="AOB60_28475"
     CDS             complement(6973..8697)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018539792.1"
                     /locus_tag="AOB60_RS29550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28475"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_102925569.1"
                     /sec_met_domain="Pkinase (E-value: 1.9e-47, bitscore:
                     159.4, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGEGTERAVTAGGASGEELIGKVLGGRYRVTATIGRGGMGVVAR
                     AVDQLLNREVAVKVLRAFTDASAPELVDLRTRMQREAQAAARIRHSGVVTVHDVTEEQG
                     LPVIVMELVDGPSLDDVLTERGTLEPHEAAAIGAKLMDALDAAHRVGVLHRDVKPANVL
                     LEHGGRVVLTDFGIASMDASGDEAMAKLTHSGQLVGSLDYLPPERAQGTVPSPASDIWS
                     LGMTLYAAVEGTSPFRRTSVWSTLSAIVTEPLPEPRRAGPLTPVLQALMAKEPKNRPTA
                     EQAREMLQWAAAGRTMNLAPPAPMAPTPPPVQVVGPTPPQAATPAPPPGFGAVPPFHPS
                     SPQPPHTGYPPSVPPLVTQPSMPTAGHAHGAGPAAGRGRRSRRTLIAAAAAFVVLAGGG
                     VTYALTAQPGADGNGPQAAPGASSPVGNGQPSGGGTADGINSPGSSPSTGSGNPSGATS
                     PSSAPPSTKPSATPSTSASPSAKPSSGPTTCSGWSHHDPKPGMYGYLSGDHHILTGPYQ
                     VCSSVAATKSGTKLWFHCSVENAYGHKWLYVRIGGTNNAGWMSADNVIRQSGWPVRC"
     tRNA            8863..8936
                     /anticodon=(pos:1789731..1789733,aa:Met,seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="AOB60_RS29555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="AOB60_28480"
                     /product="tRNA-Met"
     gene            8863..8936
                     /locus_tag="AOB60_RS29555"
                     /old_locus_tag="AOB60_28480"
     gene            complement(9026..9874)
                     /locus_tag="AOB60_RS29560"
                     /old_locus_tag="AOB60_28485"
     CDS             complement(9026..9874)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018838402.1"
                     /locus_tag="AOB60_RS29560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28485"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_102925570.1"
                     /transl_table=11
                     /translation="MPALLRPALEPFLDLLRCPVCRGSLRPDRGALRCATGHTFDIARQ
                     GYVSLLTGTRATSGDDTAMVQARNRFLSTGRYAPIRRTLARLTADALPGRGTVVDVGCG
                     TGYYLAGVLDQLPDARGLGLDASVCALRSAARAHQRAAAASWDVFRPFPLVDQAADVVL
                     DVFAPRNPSEFHRVLRPSGRLIVVRPTERHLAELRGHLPAMVTIDPDKEQRLQQALGPF
                     FEAAVTRHVAYTAPLTRQEAIDLLGMTPSARHLTHADLGAHGLLPDQVTVSVLATSYQP
                     R"
     gene            complement(10001..10426)
                     /locus_tag="AOB60_RS29565"
                     /old_locus_tag="AOB60_28490"
     CDS             complement(10001..10426)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004949361.1"
                     /locus_tag="AOB60_RS29565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28490"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_073449291.1"
                     /sec_met_domain="PF13471 (E-value: 5.9e-27, bitscore: 91.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSVVPHRTEVRLSPGRRLLVLLAVAVARRLAAKPPARTRALLTR
                     LRRGARAATYAEARDARDAVVAVSLRCAGDEGCLPRSLATVLLCRARGTWPTWTVGVRA
                     RLPFGAHAWVEAEGRMVEEKADPSYFRPLFSVPAEGA"
     gene            complement(10423..10683)
                     /locus_tag="AOB60_RS29570"
                     /old_locus_tag="AOB60_28495"
     CDS             complement(10423..10683)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004949363.1"
                     /locus_tag="AOB60_RS29570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28495"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_073449290.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 6.2e-25,
                     bitscore: 84.6, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.3e-13, bitscore: 48.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWRLHPDVSTVDTDYGTVLLNGSDGRYWQLNATASLAFRALVEG
                     STVQETTERLMASFDVDEPRARADVEQLMASLRQAKVVQQA"
     aSDomain        complement(10432..10683)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AOB60_RS29570_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="5.40E-27"
                     /identifier="RREFam002.1"
                     /label="AOB60_RS29570"
                     /locus_tag="AOB60_RS29570"
                     /protein_end="84"
                     /protein_start="0"
                     /score="84.6"
                     /tool="antismash"
                     /translation="MTWRLHPDVSTVDTDYGTVLLNGSDGRYWQLNATASLAFRALVEG
                     STVQETTERLMASFDVDEPRARADVEQLMASLRQAKVVQ"
     gene            complement(10715..12535)
                     /locus_tag="AOB60_RS29575"
                     /old_locus_tag="AOB60_28500"
     CDS             complement(10715..12535)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="AOB60_RS29575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28500"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_102925571.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.2e-39, bitscore:
                     134.6, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADAGWQYFVALPDDEGAAAAIGRFPTDGVRVLLRHRSGRPCVAG
                     RLADDRVLVAERGDTRLAVIGHCSATRDELATAADRIDDLTDLDRMGLAWAGSYHLVAS
                     VRGRLRVQGTASGLRRIFHGELGTLTIAADRADVLATVLDAPLDPALLALRTLDVLPHP
                     LGDQPPWRNVSAVPPGWYLALPQDGRRSLVERWWQAPEPVRSLTAGGQLLRQALEDAVR
                     VRARGARPISADLSGGMDSTSIALLAVRHRPSLTVLTMENDDRADEDARWARQAAAGLP
                     DLNHIVYSSRELPRFFGGLTSVEGVPDEPSTAVLSAPRLRAVRQRALAHGSRLHLDGLG
                     GDQLLCGHPAYHHDLLRHRPLLAAQRLRVLTQLRRSNWGTEARGLLEGHSYRRWFTDRA
                     HGRALRTPSPLSAWGHFPGLPAWLTPDARDLVTRTLCDTAATVEPLASTRGRHNDLLAI
                     QDAGRMVRQCHQLTETGDFSHTSPFLDDRVIQACLAVRPEQRVTPWEFKPLIKAAMADV
                     MPPEVLTRRTKGDGTTIVAEGFEAHRRELAELWDDSRLAALGLVDPGPLRELFDLPYTN
                     SLHQGAMQSALSCELWARATAFQPAAATRP"
     gene            complement(12575..12724)
                     /locus_tag="AOB60_RS44775"
     CDS             complement(12575..12724)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF039305.3"
                     /locus_tag="AOB60_RS44775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_107080297.1"
                     /transl_table=11
                     /translation="MQGNELQETDKLQTYEAPKMIECGSFQEDTGYFGLTGYENLFHFY
                     DKLH"
     CDS_motif       complement(12632..12724)
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MQGNELQETDKLQTYEAPKMIECGSFQEDTG"
                     /locus_tag="AOB60_RS44775_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       complement(12575..12631)
                     /prepeptide="core"
                     /locus_tag="AOB60_RS44775_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="2.20"
                     /molecular_weight="2246.5"
                     /monoisotopic_mass="2245.1"
                     /core_sequence="YFGLTGYENLFHFYDKLH"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MQGNELQETDKLQTYEAPKMIECGSFQEDTG"
                     /leader_location="[12631:12724](-)"
     misc_feature    13217..13231
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.29"
                     /tool="antismash"
     gene            13281..14276
                     /locus_tag="AOB60_RS29585"
                     /old_locus_tag="AOB60_28505"
     CDS             13281..14276
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049074.1"
                     /locus_tag="AOB60_RS29585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28505"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_102925572.1"
                     /transl_table=11
                     /translation="MDTEALRSFVRAAELGQFQHAADELGVTQQAVSKRIATLERELEV
                     RLFTRTARGVELTLDGQAFLSHARSIVAGVERAINAVRPGSRALRIDVLGLRSAQAVVL
                     HDYWRSRPEANLDVVTLRANDPRVVVAAVEAGDIDASFRTVIAPAVLPPDLQMIHAFDS
                     PLELLVGPRHPLASARRLTPPQLHKHRIWVPGIAPRSEWAEFYDQLATDFDLRIDAAGP
                     HFGDEVLLDTLAESADVATLVGARDRYIWPTNHDLRRIPIVNPTLAYPLSLILPRTNPH
                     PELRGIINHLGTLPRLPDAVWRPSWATTPQRAESGESDIENAQRSRPRPR"
     gene            complement(14587..15249)
                     /locus_tag="AOB60_RS29590"
                     /old_locus_tag="AOB60_28510"
     CDS             complement(14587..15249)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017946215.1"
                     /locus_tag="AOB60_RS29590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28510"
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_102925573.1"
                     /sec_met_domain="HAD_2 (E-value: 6.5e-10, bitscore: 36.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARGTDGCTPYRGLILDFVGVLTGGVQAALHSWCASEGLAPDAWR
                     ITLADLPEGRELYAALESGRLSQAEWNRRTAPLLGVDDHHNLMGRAWSGVRPAVNMIAL
                     ARAARRAGYTVALLSNSFGLDPYDPYEALGVWKLFDVTVISEREGIAKPDPEIYQRTLE
                     RMDLPGEACVFVDDNPGNLPPAAALGITTVHADGQADTVKRLSSLLGILPAAGRVHR"
     gene            complement(15454..15774)
                     /locus_tag="AOB60_RS29595"
                     /old_locus_tag="AOB60_28515"
     CDS             complement(15454..15774)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018539294.1"
                     /locus_tag="AOB60_RS29595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28515"
                     /product="hypothetical protein"
                     /protein_id="WP_073449286.1"
                     /transl_table=11
                     /translation="MRNKPDSAEFVSGGTRHTVTRAQVEAAASRLSPAHSATFSKNREW
                     YALVGTGLHYVTDLVAEATGTKPSDVETARLALDALGFPIVCWAWGDLLTTGHPGHRVR
                     ST"
     misc_feature    complement(15868..15882)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.21"
                     /tool="antismash"
     gene            complement(16052..16510)
                     /locus_tag="AOB60_RS29600"
                     /old_locus_tag="AOB60_28520"
     CDS             complement(16052..16510)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025789.4"
                     /locus_tag="AOB60_RS29600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28520"
                     /product="SUKH-3 domain-containing protein"
                     /protein_id="WP_180990313.1"
                     /transl_table=11
                     /translation="MPVSISRDEVLQWLTRNGWSPDRGIEEEAREFVSEVVADSEKEGF
                     SAVPFDAAVRFITTYGLLTLTHPSDPESKLITNPTGGYEGDFSEIADLSRELGKHLFRI
                     GYDLPDAGIFVVAEDGEFYCIHHTGAYYLGSDAFEFFDNWAKGDMQSV"
     gene            17183..17641
                     /locus_tag="AOB60_RS29605"
                     /old_locus_tag="AOB60_28525"
     CDS             17183..17641
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022432.4"
                     /locus_tag="AOB60_RS29605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28525"
                     /product="DUF2786 domain-containing protein"
                     /protein_id="WP_102925575.1"
                     /transl_table=11
                     /translation="MVAPGGPSEPEDAPSVCRRLPSLRALAEHPRTPRAERELAAALAA
                     ALMKRYGLGPPERRDGTARDGIIVVRREPDKTVEVLVLDPDAERATRQIAGTTGRDGGA
                     PASWNVHRLNAQGLNPGIAVWRKAAALHVSAGTYQARPRPREKREEIV"
     gene            17638..18372
                     /locus_tag="AOB60_RS29610"
                     /old_locus_tag="AOB60_28530"
     CDS             17638..18372
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AOB60_RS29610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AOB60_28530"
                     /product="hypothetical protein"
                     /protein_id="WP_102925576.1"
                     /transl_table=11
                     /translation="MTAHVPPAGADTTADLASDALARARAAGDRRAEARALCDLGAALT
                     RAGRAGEGRYLCRRAAGLAAEVGDRPAEEAAFGALGHNLAELDALGERWRAVLLEGGDE
                     TGFFASPAAARSDASYATGGRPDDAPARLTGVPVVELACGFVAVKFLGPFVESFAGKLG
                     ERLGESTVTATGRLRLLWHRRSGRRDLDVLTPGERTTLVLPDDFDDAARLAAIDLDLGA
                     DGVRGAELHWDADAGTWSPVNT"
     gene            18402..19019
                     /locus_tag="AOB60_RS29615"
                     /old_locus_tag="AOB60_28535"
     CDS             18402..19019
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AOB60_RS29615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AOB60_28535"
                     /product="hypothetical protein"
                     /protein_id="WP_073449282.1"
                     /transl_table=11
                     /translation="MREQAVCDTCGTTTRRSSGYHLPTKHVVVSEAYWRSFFRTAVGLV
                     RALDWDERAQAGAFDRLISQSASSATPWLVCEECSEWFVFDRAAAREHARSGSVPEGSG
                     AVDPAGFALFAAAAWEYVVGRWPASVQQPTVGDTCDLCAKKIYQGELVGRIGAGTAEAY
                     LASGVLETPPLSPPRPDQQGWLACWVCVSRVQTRAGRARGGR"
     gene            19016..21928
                     /locus_tag="AOB60_RS29620"
                     /old_locus_tag="AOB60_28540"
     CDS             19016..21928
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024180.4"
                     /locus_tag="AOB60_RS29620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_28540"
                     /product="CHAT domain-containing protein"
                     /protein_id="WP_146051221.1"
                     /transl_table=11
                     /translation="MSSELARAEALFEQGRDLFLRGRYQDAVRLLAAAAELAPTSVGCQ
                     FMLGAGRWNSGDTAGALYPLALCVYLDSEHASGRFALGVALRELGQPEQGAVHVAYAAY
                     RGNRQAAAHLGELTLAHCPDCGGPVTSGAARCDGCAGIPREISAPRPRTWSWPHLRSDD
                     ARSRWTLPYEQLADLGRGHLTRYAGHGDPHDIDDALAYLELAAATASAADRPARLTELG
                     SAYRQRFACHGLPADLDHAIDCHEQALDQAAADTPEQVIVLANLGVAYGARHESSAAAA
                     DLERAIGFLERAMAAPTEDPDEHLSAMASAGVLYQRRHRAGGDEADLDRSIALQDAVVE
                     ASPPDHPRYAGRMANLTVAYLNRYERHRRLPDLERALLLADRAVAATPRDSPALPIRLA
                     ARGSTWLQLHLADLPGESGGTRDRPLDRALDDLRRALDAAPDGQLHVADVLAELVRAHL
                     VPGARHMAPDRRTLEAWEARLKAARGATPSKRAVAGRNLGVLANVLGEYDLAARVLDAA
                     IALTPAVPLRGTDWTDQERRFGEPRGLASQAFAAHCARGEPLQAVQQAELGRGIQLATV
                     LDAHDDLADLESELPELARPFRQVRKELAAGSAAEAVLWDRYGQLVARIREHPRFTRFL
                     MTPRVEELRRAAGGGTVVVVNSARNRADAILIGHDGDLKQVPLPDLSADHVEAQSEAVV
                     GSAHAGLADRLGWLWDTVVGPVAEALPPGATPRRVWWLPIGLLGMFPLHAAGHPGRPGA
                     LDSFVSSYTPTLRILAHAHGHPAAVARRQLTVALPSTPGLPGLPGALTEALDLHRRHPD
                     QPPLLNEDATTSQVAAALSTATWAHFACHALADHAAPSHSGLCLSDGMLTIPEISRLAV
                     ADAQLAYLSACSTGHRSLEHVDESLNLASAFQLAGFRHVIASLWPLADAFGAVAARTFY
                     AELSGTADDAPGALHRTTLAMRDRYQGRPDLWASLIHSGP"
     misc_feature    19355..19357
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(22063..22077)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.76"
                     /tool="antismash"
ORIGIN
        1 cggtggccgt gacatcggat ccgaagacga cctggtagcc gcgttcgtat gcctgccggg
       61 ccgtggtgcc gcagcagtag ttggtgagcg ttcccgtgac gatgaccgtg tcgcggccga
      121 ggttgcgcag cacggtgtcg agcggggtgt cgtagaacgc cccgtaggac ggcttgcgga
      181 tcacgacctc atcggggcgg cgccccatcc ggccccagac ctcggcgggg cccggtcggc
      241 gccagtcggt gtcggcgtgc gggaggaagc gcagggcgtg tggccggtcc agtccgagat
      301 gggtgtcgtc gaagatcgtc cagatcaccg ggaccgaggc gtcccggcag tcttcgacca
      361 gttgccgcag ccggggcgcc atccgggtcg ccgcaggcac ccagtagggg ctccagccgg
      421 gccggacgaa ttcgtcctgc atgtcgatga ccagcagcgc cgtccgttcg ggtcgtaggt
      481 cgaacgatgc ctggccgtgc tcgtaggcgt ggcgcgcccg cgcggtcacc cattcctcgg
      541 tgtacgtcat ccctgccccc tatatcgatt cgaggtacct cgtttcgatg tgcgagagta
      601 gcagcatgct cgaactcgcc atcctgggat tcctggccga ggggccgctg cacggctacc
      661 aactgcgcca ccggatcgcg cacttgtccg gccatgcccg gccggtcagc gacggcagcc
      721 tctacccggc gatcaatcga ctggtacgtg ccgggctgct cgaccgacgg accgaaccgg
      781 gcacctcggc cgcccagcgc cacaccctga gcctgaccga caccggccgc cgcgagctgg
      841 tgcgccgact gcgggatgcc aacggcctcg acatcaccga cagtacccgg tacttcacgg
      901 tcctggcctt cctctcccaa ctgcccgaca ccaccgacca gcacgcggtg ctgcgccgcc
      961 gactggaatt cctggaacag cccgcgagct tcttccacga cggcgaccgc cccctgcgta
     1021 ccgacgacac cgacgacccc taccggcgcg gcatgctcac cattgcccgc gccaccagcc
     1081 gcgcggaaag gtcctggctt cgggaggtgt tggcctgaca cggcctcggg tcagccgccg
     1141 gtcacctgct gccacaaccc gccgctgccg ccgtcgagta cgtgccggcc gatcctttgc
     1201 tgccaggccc gttcaccacc gtcctcgtcg cgccaggacc acatgcgggt ggtggccagg
     1261 cggagcgggc tgagttcggt gaaaccgatc gcgccgtgca gttggtgggc gatgcgggtg
     1321 atctcggcca ccgaggcggc ggcctgtgcg gcggcgagcc acgcggtgaa ctccgcagag
     1381 tccggctcgg acagggcgga cgcggccgcc tcgacggccg cggcgaccaa ggccgcctcc
     1441 tcgacgagct tggcctcctc ctgcttgacg gcctggaagt ggctcagcgg tcggccgaac
     1501 tgcacacggg aggaggtgtg atcgaccgtc agctcgacac agcggcgtgc cgcaccggcg
     1561 atcagggcgg cccgcgccag gccggaacgc catgtcgcct cccggaccag cgcagccgga
     1621 acgcggcgga cccgctcggc ggggacggcc acatcgagca gcaccaggtc gtccctgggc
     1681 tcgcccgcca ggttggtgcc cgccacctgc cgccactcgg tggcttcgag gaggaagagc
     1741 acgggcccgc cgcccgggcc ctcggtcagc accaccgcgg cttcgacggc ccgggcccac
     1801 ggcacccggt gcagcgtgcc gctgacccgt agggcgtcat cggtgcctgc cgcccctgac
     1861 ggcccgaccc tgctgtcggt gtccacgtgg gcgaaccgca cgtcgagcgg gccggcagcc
     1921 acggtgagct ggccgtcagg gacggcgagc cccgccgcgg ccagcaacgg gcgtgcgacg
     1981 agcagcgtct cggcgagcgg tgccgcggtg ccgcggtagc cggcatcccg tgccagggcc
     2041 accagggcgg tcggagccgt gtcgagcggc ggcagggcgt cggcggcgtg ttcggagagg
     2101 ggttcggcga cggactcggc gcacgattcg atgctcatcg ggacagctcc agacctcggg
     2161 tgatgatgcc gcgcaggatt tcgttggtgc cgccgcgcag cgtgtatccc ggcgcatgca
     2221 ggatcgcggt ggccagcagt tcggggtagc tgccgcgggt ggcgtcgaag cgggcggcga
     2281 tcggcaggat ctcgcggacc tcgttgacga gttcgccctc gaagcgggtc ccgaggtcct
     2341 tgaccagggc cgcctgcacg tcggcggggc ggccggccgc cagcgccgcg gccaccccca
     2401 acgacagctg ccggatggac gccaggcgcg cggtgagccg gcccacccgg gcctgctgct
     2461 cgggactgca cgcgccggtc cgctgcaact gtcccaccag ggcggaaagg agcggcagcg
     2521 tggacaggaa gcgctcgggt ccgctgcgtt ccagggccag ttcgccggtg acctgccgcc
     2581 agccgtcacc ggggcgcccg agcagtgcct cgtcggtgag ctcgacgcct tccaggtggc
     2641 agtagttgaa ggtgtgctcg ccgctgagga gacggatcgg ctcgacccgg acgtgcggat
     2701 cgcgcaggtc gacgatgaac tggctcagac cggcgtggcg gtcctcggac tcgtcggtcc
     2761 gggcgagcac gatcgcgtgg tcgttgacgt gcgcaccgcc cgtccacatc ttggtgccgg
     2821 tcaaccgcca gccgttggcg gtccgctccg cccgggtccg taccgaggcc aggtccgacc
     2881 cgctgtcctg ctcgctcatc ccgatcgaga agaagcacgc gccggcggcg atccggggca
     2941 ggaagtggct ccgctgcgcc tcggtgccgt ggcgcagaat ggtgggcccg gcctgccggt
     3001 cggcgaccca gtgggccgag accggggcgc cggcggccag caactcctcg atgacgacgt
     3061 agcgttcgag gttgctgcgc ccgcctccgc cgtacgcccg cggcagggtc atgccgaccc
     3121 agccgcgccg ggccaggcga cgggtgaagg cggggtccca gccggtcagc caggagtcgg
     3181 gccgaccgag gacggtgccg gcggcccgtt ccgcggcgag gaagtcgcgc acctcctgtc
     3241 gtaaccgggt tgcttcgggg ggaagttgga cggccccgag atcgaggtcg gagagggtca
     3301 tcgggtactc ctcggacgga atggtgggtg tatggagtga cgggtatacg cagtggtggg
     3361 tgtgcggggt gacgggtgcg cggtcggcgg tggtggtcag gtgcccgtga agtgcgggcg
     3421 gcggcgttcc cggcgggcct ggacgccctc gcggaagtcg tcggtggtgg tcgtcaccgg
     3481 ctgggcgagt ccctcccagg tcagcgcccg ctcgacggtg ggctgcccct gggccaggcc
     3541 gctcttggtc agccggaccg ccagcggggc cgcggcggcg atctcgtcgg ccacgtcgag
     3601 cgcggcccga agcacctggt cggccggcag cgcctcgtgc accatgccga tggtggcggc
     3661 tcgtgctccg ctgatcagcc gcccggtcag cagcagttcc cgcgccctcg acgggccgac
     3721 ggcctcggcg agcagggcgg tggtggccat gcccgggtgc aggccgagtt ggacgaacgg
     3781 cgcgccgagc ttcgcctccg ccgcggcgta ccgcaggtcg caggccaggg ccagcgccag
     3841 tccggcgccc accgcgtggc cgttgacggc cgccacggtg gggacggaca ggtcacggac
     3901 ggtcagccag gtccggtaga agtccgacag ctgggcccgg gtgccggaca ggggctggcc
     3961 gtgtcggtcg gcgagttccc ccaggtcggc gcccgagcag aacgcggggc cggtgccggt
     4021 gatcacgagg gcgcgcaggt cggggtcctg gcgcagggag cgcatggcgc gccgccactg
     4081 tgcggtcagc cgtccggtca tcgggttgcg cttgtcgggg ttgtcgaagg tgagcacggt
     4141 gacgccgttc ggccggtgct cgacgcgcag cggttcccac gcgttcggcg ctgcctgctc
     4201 gtccaggtgt gcttgctcgt tcacggggcc tcgattcggt ccgcgggtac gggtgttggt
     4261 gactgctggt gactggtgag ggctcaggaa ggtggccggt ggccgatctc ggcgaagacc
     4321 tcctcggtgt gctcgccgac ccgcgggcag tgccggtgca ggccggccgg tgtggcccag
     4381 aagcgcacgg gctggccgat gaggcggtag ccgccctcgg tggggtgctc ggcctcccgg
     4441 agcagaccgc cttcggcggc gtaggcgctg gtggcggcct ccgtcaggct cagcaccggg
     4501 gcggcgggga tgctggtcgc gtcgcagaac tcctgccatt gcgcgttggt gtgccgggtc
     4561 gtgaactcac cgaccagtac gtagagttcg tcggcgtggt ggacgcgcgc ggcgtacgac
     4621 gcgaagcgcg ggtcgtcggc cagttccggg cggcccacga aggcgaagaa gtcacgccag
     4681 ttgcggtcgc tgtagggcag gatgcacatc cagccgtccg ccgtacggga ggccgtgcga
     4741 cgggggctga gcgcccgcgg gtagccgatc ggcccctcgg gcgggctgag ggtcgccgct
     4801 gccaggtgct cgacgaggtt gaaggccagc atggtgtcgg ccatcgggac ctcgacgtgc
     4861 tggccttggc cggtgcggtc acgatgatgg agcgcggcga gcaccgactg cacgatcacc
     4921 aggccgcaga tcttgtcggc cagcacggtg ggaacgtagt gcgggacgcc gctgacctgt
     4981 tcgttcagcc acaccaggcc ggaggccgcc tgcacgacgt cgtcgtaggc cgcgtgcccg
     5041 ccgagggggg aatcgctgcg gaagccctgg gcgttgaggt agaccaggcc ggagttgacg
     5101 gccgccacgt cctcgtaggc caggtcgagg cgccgcaggg cctgcgggcg gacgttggtg
     5161 aggaagacgt ccgcgctcgc gaggagggcg agcagggcgt cgcggccgcc cggggctttg
     5221 aggtcgaggg cgacgctgcg cttgttgcgg ttgaggttga gggtcatcac ccccatcccg
     5281 gggctgcggg tcggcgggta gtggcgggtc aggtcaccgg tcggcggttc gaccttgatc
     5341 acgtccgccc ccaggtcgcc gagctgttgg gccgcgtacg ggcccatgat cacgctggcc
     5401 agctcgacca cccgcacgcc gttcagtgga ccgaggccac cgtctgtttc ccgtcctgtc
     5461 gacatggcac gtctccgatc tccgccgggg ccggcttcgc gcgccggacc gttgacagcc
     5521 agtcaaatcc tcggcgaccc atatcgtcca atacttcttc cctgcggctt acatatgctg
     5581 tgcgatatgg aattgaccca gcgcatcctc caacagatcg tcgtgttggc cgaggaacag
     5641 cacttcggcc gcgctgccga gcggctcgcc atgcgccagc caccactcag ccaggcgatc
     5701 caacgactgg aacgcggcct cggcgtcacc ctgttcgacc gcctgccgcg aggagcccga
     5761 ctcaccccgg ccggccgcgc gttcgccgag gacgcccggc ggctgctcga agcacaggcc
     5821 gccgccgtgg accgggcccg gcggatcgct agcggacacg agggcgagct ccggctcggg
     5881 ttcatcagca gcctcggcta cgacttcctg ccgcgcctac tgcgccgcac ccatgcgcag
     5941 ttgcccgagc tgcggctgca cctgggtcaa cacccctccg cggaactggt cgacatgctc
     6001 caggccggga cgctcgacct cgcactggtc cggctccccg tcaccggcac ggaacgactg
     6061 accgtccggc ggatcggcgt ggaacgactg gtggcggtcc ttcccgaaca ccatccgctg
     6121 gtcgccacct cacgcctcga cctgcgggaa ctcgccgagg agtggttcgc ggtgcccaag
     6181 ccgggcgccc tgcccggact ggccgagcag gttgcgctcg cctgcgcgca ggccggcttc
     6241 acgccccgac cacgcggcca ggcggacgac ctgccggggc tgctcagtta cgtcgccgcc
     6301 gggctgtgcc tggcgctcgc ccccgagcag gtgcgcacgt tgggcatccc gggcgtggtc
     6361 taccgtcccc tgcacggcga ttccccctac ctggagagca cggtcgccgc cgtgcaccgc
     6421 gcggacggcc ccgatgccgc cgtgcaacag gtcctgaagc tgatcgagcc ggatctgccg
     6481 acggtcgagt gcacgccgta gaccgaagtg accacgttgc gcggggcagg tccgcttcac
     6541 gccgggattg cgttcttgga gattgcctgg aaggccctgg cgtgatccgt cggcggcaga
     6601 agcgaggtcg atgtgcaagc gttcctggag cacgcccgta gccttcccca gcgcgtcacc
     6661 caacagggcg gcaacttggg caagttggct catggccagc ggccgatggc ggtgttcatc
     6721 acgtgctcgg actccggcgt ggtccccacc atgttcaccg gagcccgacc cggcgaactc
     6781 ttcgagttac gggtagcggg caacatcgtc cctcggccac gggacacgtg ccgcaggcga
     6841 gccgccgacc gcacgcacga cgcgcgtggc acattccgac cggccgctgc cagcccctgt
     6901 gaacggcatg ccgtagcgct gtgagcttcc tccatcggga cgttccgacc gtggacggct
     6961 tcgatcgcgc cgctaacaac ggactggcca gccgctctgc cggatgacgt tgtcggcgga
     7021 catccagccc gcgttattcg tcccgccgat gcggacgtag agccacttgt ggccgtaggc
     7081 gttctcgacc gagcagtgga accacagctt cgtgcccgac ttggtcgcgg ccacagagga
     7141 gcagacctgg tagggccccg tcaggatgtg gtgatcgccg gacaggtagc cgtacattcc
     7201 cggcttcggg tcgtggtggc tccagccgct gcaagtcgtc ggccccgaac tgggcttggc
     7261 cgaaggggaa gcggacgtgc tcggcgtggc actgggcttg gtcgacggcg gggcggagga
     7321 gggagaggtc gcaccggacg ggtttccgga tcccgtggac ggcgaggagc ccggggagtt
     7381 gatgccgtcg gctgttccgc cgccgctcgg ctgaccgttg cccaccgggg agctggctcc
     7441 gggcgctgct tgcggcccgt tgccgtccgc accgggctgc gcggtcaagg cgtacgtgac
     7501 accgcctccc gcgagcacga cgaaggcagc cgcggccgcg atgagggtac gacgtgagcg
     7561 ccggccgcgg ccggcggcgg ggccggcacc gtgagcgtgg cccgcggtcg gcatcgaggg
     7621 ctgtgtgacg agcggcggga cagacggtgg gtaaccggtg tgcggaggct gcggggacga
     7681 cgggtggaac ggcggcacgg caccgaatcc gggcggcggc gccggggtgg ctgcctgggg
     7741 aggcgtcggg ccaacgacct gtaccggcgg aggggtgggg gccatgggcg ccggcggcgc
     7801 gaggttcatc gtcctgcccg cggccgccca ctggagcatt tcacgcgcct gctcggccgt
     7861 gggccggttc ttcggctcct tcgccatcag tgcctgcagc accggcgtca gcggacccgc
     7921 gcgccggggc tccggcagcg gctcggtgac gatcgccgac aaggtggacc acacggacgt
     7981 ccggcggaac ggtgacgtac cttccaccgc cgcgtacagc gtcataccga gcgaccagat
     8041 gtccgacgcg gggctgggca ccgtgccctg cgcgcgctcc ggcggcaggt agtccaggga
     8101 gccgaccagc tgaccgctgt gggtcagctt ggccatggcc tcgtcgccgg aggcatccat
     8161 ggaggcgatg ccgaaatcgg tgagcacgac ccgcccgccg tgctccagca gcacgttcgc
     8221 cggcttgacg tcccggtgca gtacgcccac ccggtgcgcg gcgtcgagcg cgtccatcag
     8281 cttggcgccg atcgccgccg cctcgtgcgg ctccagcgtg ccgcgctccg tcagcacgtc
     8341 gtcgagcgaa ggtccgtcga cgagttccat gacgatgacc ggcaggccct gctcctcggt
     8401 cacatcgtgc acggtgacca cgccgctgtg ccgaatacgg gcggcggcct gcgcctcccg
     8461 ctgcatccgg gtccgcagat cgaccagttc gggtgcggag gcgtcggtga aggcccgcag
     8521 taccttgacg gcgacctcgc ggttcagcag ttggtccacg gcccgggcga ccacgcccat
     8581 gccgccccgc ccgatcgtcg cagtcacccg gtaacggccc ccgaggacct tgcctatcag
     8641 ctcttcgccg ctcgctcccc cggccgtcac cgcacgctcc gttccttcgc cgctcatcgc
     8701 ttttcgtcgt tcgtccctgg cgccccagag tagaggcagc aaaaccggag gcgacacggg
     8761 gaggggatcg cacagcggta ccccctggcg ggcggatacc gcgggccggg cggaggccga
     8821 ttcggccgat ccggggaagt gccgtagagt tcctgttgtc gacgcggggt ggagcagctc
     8881 ggtagctcgc tgggctcata acccagaggt cgcaggttca aatcctgtcc ccgctactca
     8941 catgtgaagg cccggtggtt tccaccgggc cttcactgtt cgttcccact ggtcgtcggt
     9001 cagcgggcgg gtccgccgct ggtggtcatc ggggctggta ggaggtggcc agcacggaga
     9061 cggtgacctg gtcgggcagg aggccgtgag cgcccaggtc cgcgtgggtc aggtggcgtg
     9121 cactcggtgt cattcccaac aggtcgatgg cttcttgcct ggtcaggggc gcggtgtagg
     9181 cgacgtgccg agtgactgcg gcctcgaaga acggccccag ggcctgttgc aggcgctgtt
     9241 ccttgtccgg gtcgatcgtg accatcgccg gcaggtggcc gcgcagttcg gccagatgcc
     9301 gctcggtggg gcgcacgacg atcaaccgac cggacgggcg gagcacgcgg tggaactcgg
     9361 acggattgcg cggggcgaac acgtccagca ccacatcggc cgcctggtcg accaacggga
     9421 acggacggaa gacgtcccag ctcgccgccg cggcccgctg atgggcgcgg gccgccgaac
     9481 gcaacgcgca gacggacgcg tccagcccca gaccgcgggc gtcgggaagc tgatcgagca
     9541 cgccggccag gtagtagccg gtaccgcacc cgacgtccac caccgtgcct cgaccgggca
     9601 gggcgtcggc tgtcaggcgg gccagggttc ggcggatggg ggcgtatctg ccggtggaca
     9661 agaaccggtt tcgggcctgc accatggccg tgtcgtcacc gctggtggcg cgggtgccgg
     9721 tcaggagact gacgtagccc tggcgggcga tgtcgaaggt gtggcccgtc gcgcagcgca
     9781 gtgcgcctcg gtcgggccgg aggctgccgc ggcacaccgg gcagcgcagc aagtcgagaa
     9841 acggttcgag ggcggggcga agcaacgcag gcacgaggcg ctccaggcaa cagcgaaggg
     9901 aagggagcgt gcctgcacgc acccgtgggg tcctctcccc tccatcctac gagcccaccc
     9961 cgctgcgcct caccgtcccc cgacggttca gagacccgcg tcaggcccct tccgccggca
    10021 ccgagaacag ggggcggaag taggacgggt ccgccttctc ctcgaccatg cgtccctcgg
    10081 cctcgaccca cgcatgggcg ccgaacggta gacgggcgcg tactcccacc gtccaggtgg
    10141 gccaggtgcc gcgtgcccgg cagagcagga cggtcgccag cgaacgaggc aggcacccct
    10201 cgtccccggc gcagcgaagg ctgacggcca ccacggcgtc gcgggcgtcg cgggcctccg
    10261 cgtacgtggc cgcgcgggcg cccctgcgca ggcgggtcag cagggcgcgg gtccgggccg
    10321 gcggcttggc ggccaggcgc cgggcgacgg ccacggcgag cagcaccagg aggcggcggc
    10381 ccggcgagag ccggacctcc gtgcggtgcg gtacgaccga gctcacgcct gctgcaccac
    10441 cttcgcctgc cggagactgg ccatcagctg ctccacgtcc gcccgggcac gcggctcgtc
    10501 gacgtcgaag gaggccatca gccgctcggt ggtctcctgc accgtgctgc cctcgaccag
    10561 ggcacggaag gcgagggagg cggtcgcgtt gagctgccag tagcggccgt cgctgccgtt
    10621 cagcagaacg gttccgtagt cggtgtccac ggtcgagacg tcggggtgca gtctccatgt
    10681 catggttgtc tcctgctcgg gtcctgtggc gggctcaggg gcgggtggcg gctgccggtt
    10741 ggaaggccgt tgcccgggcc catagttcgc agctgagcgc ggactgcatc gcaccttggt
    10801 ggaggctgtt ggtgtagggc aggtcgaaca gctcgcgcag cggtccgggg tcgaccagac
    10861 ccagggcggc caggcgggaa tcgtcccaga gttccgcgag ttcccgacgg tgcgcttcga
    10921 agccctcggc gacgatggtg gtgccgtcac ctttggtccg tcgggtcagc acctctggcg
    10981 gcatgacgtc cgccatcgcc gccttgatga ggggtttgaa ctcccaggga gtgacgcgtt
    11041 gttcgggtcg tacggccagg catgcctgga tgacgcggtc gtcgaggaag ggggaggtat
    11101 ggctgaagtc cccggtctcg gtcagttggt gacactggcg gaccatccgt ccggcgtcct
    11161 ggatggccag gaggtcgttg tgccgccctc gcgtcgacgc gaggggctcg acggttgcgg
    11221 ccgtgtcgca cagggtgcgg gtcaccaggt ccctggcgtc cggggtgagc catgccggca
    11281 ggcccgggaa gtggccccag gcggacagcg ggctcggggt gcgaagggcg cggccgtggg
    11341 cccggtccgt gaaccagcgc cggtaagagt ggccctccag cagacctcgg gcctcggtgc
    11401 cccagttgct ccggcgtagt tgggtcagca ccctgaggcg ctgggcggcc aacagcggcc
    11461 ggtggcgcaa caggtcgtgg tgataggccg ggtgaccgca cagcagttgg tccccaccga
    11521 gtccgtcgag gtgcagccgc gagccgtgcg cgagggcccg ctgtcgcacg gcgcgcagtc
    11581 ggggcgcgct cagtacggcg gtggacggct cgtcgggaac gccctccacc gacgtgaggc
    11641 cgccgaagaa ccgcggcagt tcgcggctgg agtagacgat gtggttgagg tccgggaggc
    11701 cggcggcggc ctgtctggcc caccgggcgt cctcgtcggc ccggtcgtcg ttctccatgg
    11761 tgagcacggt gagcgagggc cggtgccgga cggccaacag ggcgatgctg gtggagtcca
    11821 tgccgccgga gaggtccgcg ctgattggcc gggcgccgcg ggcgcgcacc cgcaccgcgt
    11881 cctccagtgc ctggcgcaac aactggcccc cagcggtcag cgaacgcacc ggttcggggg
    11941 cctgccacca gcgttcgacc agtgaccgcc ggccgtcctg cggcagtgcc aggtaccagc
    12001 ccggagggac tgcggagacg ttgcgccacg gcggctggtc gcccagcggg tgcggcagca
    12061 cgtccagggt tcgcagggcg agcagggccg gatcgagcgg ggcgtccagt acggtcgcca
    12121 ggacgtccgc gcggtcggcg gcgatggtga gtgtgccgag ctcgccatgg aagatccggc
    12181 gcagcccgga ggcggtgccc tgtacgcgca gacggccgcg cacggaggcg acgaggtggt
    12241 agctgccggc ccaggccaga cccattcggt ccaggtcggt cagatcgtcg atccggtcgg
    12301 ccgccgtggc gagttcatcc cgggtcgccg agcagtggcc gatcacggcg agccgggtgt
    12361 cgccccgttc ggccaccagg acccggtcgt cggccagccg gccggccaca cagggccggc
    12421 cggaccggtg cctcaacagg acacgcacgc cgtccgtcgg gaaccggccg atggcggctg
    12481 ccgcgccttc gtcatccggc agcgcgacga agtactgcca accggcatcg gccatctcag
    12541 tgtccttacg gggtgtgccg catcagcgtc ggccctagtg gagcttgtcg tagaagtgga
    12601 aaaggttctc gtagccggtc agcccgaagt agccggtgtc ctcctggaag gagccacact
    12661 cgatcatctt gggggcctcg taggtctgga gcttgtcggt ctcctggagt tcgttgccct
    12721 gcatcacagt tcacctcccc gttgactggt gcgacggccc agggcggaac gcgttccggt
    12781 gcggaagggt ccgcggacgc cgggatgact cccaactcgc cgccgatcga cggggcttgc
    12841 gccccagtcg ccgccctggg tgtgatcgac agagaaccac gcggctcacc gcgattcaag
    12901 atccacaatc gaccatcctg ctatgaatat cccggaatgc cccctcccac ttttgcccca
    12961 acaaccactg acttcacacg ggttgcacta tcaacacccc aaggacccgc cccacccctc
    13021 acccacgaaa ccgacgccag ccacacccca ccgaagacac acccaccaac cacggctacg
    13081 gctacggcta cggctacggc tacggctacg gctacggcta cggctacggc tacggctacg
    13141 gctacggcaa ggcgatctcg cctcagccct catcagccat cgctggctca ccaactggaa
    13201 caacgcccag gcggagcttg ttcagacaac cgatcctcgg ccagccacaa cgatgggttg
    13261 agcacgccta aggtgaagca gtggacaccg aggcattgcg atcgttcgtc cgggcagccg
    13321 agctcggcca gttccagcat gcggccgatg agctgggcgt gacacagcag gcagtctcca
    13381 agcggatcgc caccctggag cgcgagctgg aagtccgcct gttcacacgt accgcccgag
    13441 gggttgagct gacactcgac ggtcaggcgt ttctctccca cgcccggagc atcgtcgcgg
    13501 gggtcgagcg cgccatcaac gcggtcaggc ccggctcccg ggcccttcgg atcgacgtgc
    13561 tcggcctgcg aagcgcgcaa gccgtcgtcc tgcacgacta ttggcggtcg cgtcccgaag
    13621 ccaatctcga cgtggtgacc ctcagagcca atgacccacg cgtggtggtc gccgccgtcg
    13681 aagcaggcga tatcgacgcc tcgtttcgaa ccgtcattgc cccggccgtg ctaccacccg
    13741 acctgcaaat gatccacgcc ttcgactccc cgctggaact cctcgtcggc ccgagacatc
    13801 cgctcgcctc cgcgcgaaga ctgacgccgc cacagctgca caaacaccgg atatgggtgc
    13861 cgggtatcgc gccccgaagc gaatgggcgg agttctacga tcagctcgcc acggacttcg
    13921 acctgcgcat cgacgcggca gggccgcact tcggagacga agtgctcctg gacaccctcg
    13981 cagagtccgc ggacgtggcc accctggtcg gggcacgcga ccggtacatc tggccgacga
    14041 accacgacct acgccgcatc cctatcgtga atccgaccct cgcatacccg ctctcgctca
    14101 tcctccccag aacgaatccg catccggaac tccgcggaat catcaaccac cttggcaccc
    14161 tgcccaggct ccccgatgcg gtctggcgcc cgtcctgggc cacgacacca cagcgcgccg
    14221 agagcggcga gagcgacatc gagaatgctc agaggtcccg cccccgccca cgatgactcg
    14281 atcaccccat cgcggcgagc tcctgccccg ccctcacccg cacgcctgcc agacctgccg
    14341 agcccagcgg cgaagcacga acgtcgtcac gttgccaacc acgcatccct ggaagaccga
    14401 agacccgttg cgtgaacgcc cgaaacgccg cgcgccccga acaccatctc gcctggccca
    14461 gcaccaggca catgctccct gcacacctcc cagagtgatg tgggcagtgg ccaggacgct
    14521 ctccacctcc ccgcggcctc agaactcctc cggacccttc cggactcttc cggctccggt
    14581 gcggcactac ctgtgaactc tgccggcggc cgggagaatc cccagcagac tcgacagcct
    14641 cttgaccgtg tcggcttggc cgtccgcgtg gaccgtggtg ataccgagcg cggctgccgg
    14701 aggcagattc cctgggttgt cgtcgacaaa cacacacgcc tccccaggca aatccatacg
    14761 ttccagagtc cgttggtaga tttccggatc gggtttcgcg atgccctccc gctcagagat
    14821 caccgtcacg tcgaacagct tccacacgcc caacgcctcg tatgggtcgt acgggtccag
    14881 gccgaaggag ttcgacaaca gagccaccgt gtaaccggct cgccgagcag cccgcgccag
    14941 agcgatcatg ttcaccgctg ggcgcacacc cgaccacgct cggcccatca gattgtggtg
    15001 atcgtccacc cccagcagcg gagccgtgcg gcgattccac tcggcttgcg acagccgtcc
    15061 tgactcaagt gccgcgtaca gttcccgccc ctcggggagg tcagcaaggg tgattcgcca
    15121 ggcatcgggc gcgaggccct cagatgcgca ccaggagtgc agcgcggcct gtaccccccc
    15181 ggtcagcacc cctacgaagt ccaagatcag cccccgatag ggcgtgcagc cgtcagtgcc
    15241 ccgtgccacg cttccaccaa cctccccggt caagccacga catcgcgaag gtacccacct
    15301 ccggcgccac ggcaacggcc cgggggcggg ccgctcttca acgagggccg cctcggctcc
    15361 taccgctctc ccccacgacg cgtcggcgag cggcggcaac ctgcaggcgg ctggctacat
    15421 ctgctcgccc ccgggtgcgg caccccgctc tcatcatgtt gagcggacgc ggtgtccggg
    15481 atgaccggtg gtgagcaggt cgccccaggc ccagcagaca atggggaagc ccagtgcatc
    15541 cagagcgagt cgagcggttt ccacgtcgga gggtttggta ccggtggcct cggccaccag
    15601 gtccgtgacg tagtggagac cggtgccgac gagggcgtac cactcgcggt tcttgctgaa
    15661 cgtcgcactg tgtgctgggg aaagacgtga ggccgcggct tcgacctggg cacgggttac
    15721 ggtgtgacgc gtaccgccgg acacaaactc agcggaatcg ggcttgttcc tcatgatgct
    15781 tcgctctcat cgcagcggga atgaccggac ggatcaacag ctccttcgcg gcattcttgt
    15841 cgctccgtag ccggagcaca cagcacttgg ccaagtccat cccgagcgac ctcgtaccgc
    15901 gccgtgcggc gcgctgccgg ccccacaacg ttacggcccg caaggcgccc cacgccctac
    15961 gacatcgtct gccctagaga cgtggccgac ggacgtgcgg ggcccggaga gaggagatgc
    16021 cgccccagga atcgacatcc ctttccagcg ctcagacgct ctgcatgtcg cctttcgccc
    16081 agttgtcgaa gaactcgaat gcgtcagagc cgagataata cgcccccgta tgatggatgc
    16141 agtagaactc tccatcctcg gccacgacaa agatccctgc gtcagggagg tcgtacccga
    16201 tccggaaaag atgcttcccc aactcccgtg atagatcggc aatttcactg aaatcaccct
    16261 catagccgcc ggtcggattg gttatcaact tgctctcggg gtcacttggg tgtgtcaagg
    16321 tgagcaaccc ataggtcgta atgaacctca cggccgcatc aaaggggact gccgagaatc
    16381 cctccttttc ggaatcggca accacctcgg aaacaaactc gcgagcctcc tcctcaatgc
    16441 ccctgtccgg actccagccg ttcctggtga gccactgcag gacctcatcc cgcgatattg
    16501 atacaggcac ggcaacccct atcgatcaac catgggcgga tgtgccaagc gctggcagca
    16561 tgtcgagcat gaccttgcca gtgtcggcga tggcgtcctt ggcccgggtg cggctgtggt
    16621 ggttcttggc tctgccgatc ttgccgccgg ccttgttgcg gaacgtcccg cccgcactct
    16681 ccagtccagc ggggcttggg gatgcgggcg ccggctcttg ggggcgtacc gtccaagccg
    16741 ctcggtccgc gtgacggact cggtggagag cgatcgctgg tgcacctggg gatgctggtc
    16801 cgctgctcgc ggcagaggca atggtgttcg cttgtcttgt ggaggagctg cgctgcggtg
    16861 atgtcgccgt gatcggcgcc gaggaccacg gtgcctggac ccgcatgctc ctgctctgag
    16921 aggcagtgcg agcccaagct cgcgggcttc tgtgagcagg ccggtttccc ggccaccgca
    16981 ggtgagttca ccgcgagcca gcgcgggaga cagccagctg agagcccagg taaaagccca
    17041 ggtcagaacc ggctccgtag gagtttcagc cgcacgcggc ggcgacgggc acggagttcg
    17101 ctcgttcggc tgaggtgcga gggcgaggtc tggttcaatt cgaccgacga ggcagcggtg
    17161 tccctctggg gggtgatgtg gcgtggtcgc gccgggtgga ccgagcgagc cggaggacgc
    17221 cccgtcggtc tgccgccggc tcccgtcgct gcgggcactc gccgagcatc cccgtacgcc
    17281 acgcgcggag cgcgagttgg cggcggcgct ggcggccgcg ctcatgaagc ggtacggact
    17341 gggaccgccc gagcggcggg acgggaccgc gcgggacggg atcatcgtgg tccggaggga
    17401 gccggacaag acggtggagg tcctggtgct ggacccggac gccgagcggg ccacccgaca
    17461 gatcgccggc accacgggcc gggacggcgg cgcgcccgcg agctggaacg tccatcggct
    17521 gaacgcacag gggctgaacc cggggatcgc ggtgtggcgc aaggccgccg ccctccacgt
    17581 cagcgccggt acgtaccagg cgcggccccg cccgcgagag aagcgagaag agatcgtatg
    17641 accgcacatg tcccgcccgc aggcgccgac accaccgccg atctcgcctc cgacgccctc
    17701 gcccgggccc gcgcggccgg cgaccgcagg gccgaggcac gggcactgtg cgacctggga
    17761 gcggcgctga cccgggccgg ccgggcgggc gagggccggt atctgtgccg ccgcgccgcg
    17821 ggcctggccg ccgaggtcgg cgaccggccg gcagaggagg cggcgttcgg cgcgctcggc
    17881 cacaacctcg ccgagctcga cgcgctcggg gaacggtggc gggccgtgct gctggagggc
    17941 ggggacgaga ccggcttctt cgccagcccc gccgccgcgc ggtccgacgc ctcctacgcc
    18001 acgggcgggc gcccggacga cgcccccgcc aggctcaccg gcgtccccgt cgtcgaactc
    18061 gcctgcggct tcgtcgcggt gaaattcctc gggccgttcg tggagagctt cgccggcaag
    18121 ctcggcgagc ggctcggcga gtcgacggtc accgccacgg gccggctgcg gctgctgtgg
    18181 caccgccgca gcggccgccg ggacctggac gtcctcacgc ccggcgagcg tacgacgctg
    18241 gtcctcccgg acgacttcga cgacgccgcg cgcctcgccg ccatcgacct cgacctcggt
    18301 gcggacggcg tacgcggcgc ggaactgcac tgggacgctg acgccggcac atggagcccg
    18361 gtgaacacct gaccacgacg ccaacgaaga cgggggcacg gatgcgtgag caagcggtgt
    18421 gcgacacctg tggcacgacg acccggcggt ccagcggcta tcacctgccg accaagcacg
    18481 tggtggtgtc ggaggcgtac tggcgcagct tcttccggac ggcggtcggc ctggtgcgcg
    18541 ccctcgactg ggacgagcgc gcccaggccg gcgccttcga ccggctgatc agccagtccg
    18601 cgagcagcgc caccccctgg ctggtctgcg aggagtgcag cgagtggttc gtcttcgacc
    18661 gcgccgccgc ccgcgagcac gcacgaagcg gcagcgtccc cgagggctcg ggcgcggtcg
    18721 atcccgcggg cttcgcgctc ttcgccgccg ccgcgtggga gtacgtcgtc ggtcgctggc
    18781 cggccagcgt ccagcagccg acggtcggcg acacgtgcga cctgtgcgcg aagaagatct
    18841 accaaggcga gctggtcggc cggatcgggg ccgggacggc ggaggcgtac ctggcgtccg
    18901 gcgtcctgga gactccgccg ctgagcccgc cccgcccgga ccagcagggc tggctggcgt
    18961 gctgggtctg cgtgagccgc gtccagacca gggcggggcg ggcgcggggc ggccggtgag
    19021 ctccgaacta gcccgcgcgg aggcgctgtt cgagcagggc agggacctct tcctgcgcgg
    19081 gcggtaccag gacgccgtac gactgctcgc cgccgccgcg gagttggctc cgacctcggt
    19141 gggctgccag ttcatgctgg gcgccggcag gtggaacagc ggcgacaccg cgggggccct
    19201 gtatccgctg gcgctgtgcg tgtacctcga ctccgagcac gccagcggcc ggttcgccct
    19261 cggggtggcg ctgcgcgagc tcggccagcc cgagcagggg gccgtccatg tcgcgtacgc
    19321 ggcttaccgg gggaaccggc aagccgccgc gcacttaggg gagttgactc tggcgcactg
    19381 cccggactgc ggcggccccg tcacatcggg ggcggcccgc tgcgacggct gcgcgggcat
    19441 tccgcgggag atctcagcgc cacgcccgcg cacctggtcg tggccccacc tgcgctccga
    19501 cgacgcccgc tcgcggtgga cgctaccgta cgagcagctg gccgacctcg gccgcggcca
    19561 cctcacccgt tacgcgggcc acggcgaccc ccacgacatc gacgacgccc tcgcgtacct
    19621 ggagttggcc gcggccaccg cctccgccgc cgaccgcccc gcccgcctca ccgaactcgg
    19681 cagcgcctac cgccagcgct tcgcctgcca cgggctgccc gcggacctgg accacgcgat
    19741 cgactgccac gaacaggccc tcgaccaggc cgccgccgac acccccgagc aggtgatcgt
    19801 cctcgccaac ctcggcgtcg cctacggggc ccgccacgag tcctcagcgg ccgccgccga
    19861 cctggaacgg gccatcggct tcctcgaacg ggcgatggcg gcccccaccg aggatccgga
    19921 cgagcacctg tccgcgatgg ccagcgccgg cgtgctctac cagcgccgcc accgggcggg
    19981 cggcgacgag gccgacctcg accgttcgat cgcactccag gacgccgtcg tcgaggcgtc
    20041 cccgcccgac catccccgat acgccggccg gatggccaac ctcacggtgg cctacctgaa
    20101 ccgctacgaa cgccaccgcc gcctccccga cctggaacgg gccctgctcc tcgccgaccg
    20161 cgcggtggcg gcgacgcccc gcgacagccc ggccctgccg atccggctgg ccgcccgggg
    20221 cagcacctgg ttgcagctcc atctggcgga cctgccgggc gagtcgggcg gcacgcgcga
    20281 ccggccgctg gaccgcgcgc tcgacgatct gcggcgggcg ctggacgccg cgcccgatgg
    20341 tcaactgcac gtggccgacg tcctcgccga gctggtcagg gcgcatctcg tccccggcgc
    20401 gcggcacatg gcgcccgacc gacggacgtt ggaggcgtgg gaggcgcggc tcaaggcggc
    20461 gcgcggggcc acgccgagca agcgggcggt ggccgggcgg aatctgggcg tcctcgccaa
    20521 cgtcctgggc gagtacgacc tggccgcccg cgtgctggac gccgccatcg cgctgacgcc
    20581 cgccgtaccg ctgcgcggca ccgactggac cgaccaggag cggcggttcg gcgagccccg
    20641 gggcctggcc agtcaggcgt tcgccgcgca ctgcgcccgc ggcgaaccgc tccaggcggt
    20701 ccagcaggcc gagctgggcc gcggcattca gctggcgacc gtactcgacg cccatgacga
    20761 tctcgccgac ctggaaagcg aactgccgga gctggcccgg ccgttccgcc aggtacgcaa
    20821 ggagctggcc gcggggtctg cggccgaggc cgtgctgtgg gaccggtacg ggcagctggt
    20881 cgcccggatc cgcgagcacc cccggttcac ccgtttcctc atgacgcccc gcgtcgagga
    20941 gctgcggcgg gctgcgggcg gcggcacggt cgtcgtcgtc aactccgcac ggaacagggc
    21001 cgacgcgatc ctgatcggcc acgacggcga cctcaaacag gtgccgctgc cggacctcag
    21061 cgccgatcac gtggaggccc agtccgaggc cgtggtcggc tccgcgcatg ccgggctggc
    21121 ggaccggctc ggctggctgt gggacacggt cgtcgggccg gtcgcggagg cgctgccccc
    21181 gggggccacg ccgcgccggg tctggtggct gcccatcggg ctgctcggga tgttcccgct
    21241 gcacgccgca ggtcaccccg gccggcccgg cgccctggac tcgttcgtgt cctcgtacac
    21301 ccctacgctg cggatcctcg cgcacgccca cggccacccc gcggcggtgg cccggcggca
    21361 gctgaccgtc gccctgccga gcacgcccgg cctgcccggg ctgcccggcg ccctcaccga
    21421 agccctcgac ctgcaccgcc gccatcccga ccagccgccg ctgctcaacg aggacgccac
    21481 cacgagccag gtcgccgccg cgctgtccac cgccacctgg gcgcacttcg cgtgccacgc
    21541 gctcgccgac cacgccgcgc cctcgcacag cgggctgtgc ctgagcgacg gcatgctcac
    21601 catcccggag atcagccggc tcgccgtggc cgatgcgcag ctcgcctact tgtcggcatg
    21661 ctccaccggc caccgcagcc tggagcacgt ggacgagtcg ctgaacctcg cctccgcctt
    21721 ccagctcgcc ggcttccgac acgtcatcgc gagcctgtgg ccgctggccg acgccttcgg
    21781 cgcggtggcg gcccgcacct tctacgccga gctgtccggc accgccgacg acgcccccgg
    21841 ggcgctgcac cgtacgacgc tcgccatgcg cgaccgttac cagggccggc ccgacctatg
    21901 ggcctcgctc atccacagcg gcccgtaacc cgacgcgtgg cgcgggccgg cccatgctgt
    21961 cccgcagtcc gctccgcagg cccggcgccg tggtgcagac catggtcaac gccttccgat
    22021 cgccgcgtgc cgtctggcgt acgctcgggg tggctcaggg ggatcggggg cgctgatccg
    22081 ccaggtcgtc ctcgacgggt tccggctcgt cctggagacc gcgcaagtgg cctgccgcac
    22141 cgcgcagtcg gaccccttgg gcgcgctcga aagctatgtg ctggagctca tcgctcagcg
    22201 cgacatgctc gttctgccgc tggtcggtgg cccggtggtc gacgatccgg agatcgcgtc
    22261 ggtccagcgc gagatcgacg ccgccttgga ggatctgctt gcggccggcc gggaggccgg
    22321 cgtggtcggc tgcgacgtca cggtcatgga cgtggtcatc gcctcgacgc tggtgtgccg
    22381 gccgctgcct cacctgccgc gcgaccaggc caccgccttg gtcacgcggc acgtgcgcat
    22441 cttcctcggc ggcctcggcg gtgcggcgaa gctgcccgcg gctccgacct atgcggagct
    22501 gaccgcccgc ttgcgggcgg caggagaggc cgcgg
//
