LOCUS       NZ_LJSN01000003        21050 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces noursei strain JCM 4701 scaffold3, whole genome shotgun
            sequence.
ACCESSION   NZ_LJSN01000003
VERSION     NZ_LJSN01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces noursei
  ORGANISM  Streptomyces noursei
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 3830602)
  AUTHORS   Graham,D.E., Mahan,K.M., Klingeman,D.M., Fida,T., Giannone,R.J.,
            Hettich,R.L., Parry,R.J. and Spain,J.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-SEP-2015) Biosciences Division, Oak Ridge National
            Laboratory, PO Box 2008, MS-6038, Oak Ridge, TN 37831-6038, USA
REFERENCE   2  (bases 1 to 3830602)
  AUTHORS   Graham,D.E., Mahan,K.M., Klingeman,D.M., Fida,T., Giannone,R.J.,
            Hettich,R.L., Parry,R.J. and Spain,J.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-SEP-2015) Biosciences Division, Oak Ridge National
            Laboratory, PO Box 2008, MS-6038, Oak Ridge, TN 37831-6038, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2015
            Assembly Method :: SPAdes v. 3.6; SMRT Analysis v. 2.3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: Illumina MiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002891315.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 20:38:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,947
            CDSs (total)                      :: 8,851
            Genes (coding)                    :: 8,489
            CDSs (with protein)               :: 8,489
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 362
            CDSs (without protein)            :: 362
            Pseudo Genes (ambiguous residues) :: 0 of 362
            Pseudo Genes (frameshifted)       :: 118 of 362
            Pseudo Genes (incomplete)         :: 301 of 362
            Pseudo Genes (internal stop)      :: 23 of 362
            Pseudo Genes (multiple problems)  :: 74 of 362
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:29:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 550407
            Orig. end                         :: 571457
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LJSN01000003.1.
            Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21050
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="atropopeptide"
                     /region_number="4"
                     /rules="atropopeptide_p450"
                     /tool="antismash"
     cand_cluster    1..21050
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="atropopeptide_p450"
                     /kind="single"
                     /product="atropopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21050
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11050](-)"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11050)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
     misc_feature    complement(142..156)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.88"
                     /tool="antismash"
     misc_feature    4312..4327
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            complement(4845..5828)
                     /locus_tag="AOB60_RS23950"
                     /old_locus_tag="AOB60_23010"
     CDS             complement(4845..5828)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AOB60_RS23950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AOB60_23010"
                     /product="hypothetical protein"
                     /protein_id="WP_102924981.1"
                     /transl_table=11
                     /translation="MSEEIAALVRRLASESREDRAAAQDALAALGAPVVKHLLPLLRNE
                     ETPGNSAAESCLESLGHAAIGPLREVRAEGPGSLRKAALRMLATIGGADALSDADRAAV
                     ERLVQIKMPDEEPGDLPADCWIAVPEAEIGDIVRALDLHDVRPVTTAMGLSAAVEHENS
                     LRRPTEDGGVTTAYRVFITPEFDGWRLIYGADYLNDNWAQIVTRLSAHCREAHFYAIDD
                     YNGAQVWWVSENGHDKRGYRTYGDPEWIGEPMEFERNLMPGGDAYDDEDDDAEQYAEGV
                     RGPEEVASSISIQPTVVEVLDRVGHGWLAVTDPNVGHGRFRGALDI"
     gene            6144..6599
                     /locus_tag="AOB60_RS23955"
                     /old_locus_tag="AOB60_23015"
     CDS             6144..6599
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577361.1"
                     /locus_tag="AOB60_RS23955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_23015"
                     /product="SRPBCC domain-containing protein"
                     /protein_id="WP_102924982.1"
                     /transl_table=11
                     /translation="MSNEPMRLPDLSSRPHQLAVERLMSGTPAALYRAWTEQFDRWFAA
                     AGSVLMEGRVNTAFFFETEHEGARHPHYGRFLRLDPDRLVELTWVTGAGGTQGAETVVT
                     VAFAAEDSGTRLRLSHAGFADEAARDRHRDAWPHVLEQLDRRIGAAH"
     misc_feature    complement(6805..6814)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.63"
                     /tool="antismash"
     misc_feature    6824..6833
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.85"
                     /tool="antismash"
     gene            6893..7792
                     /locus_tag="AOB60_RS23960"
                     /old_locus_tag="AOB60_23020"
     CDS             6893..7792
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543082.1"
                     /locus_tag="AOB60_RS23960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_23020"
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_102924983.1"
                     /transl_table=11
                     /translation="MTTAVSTHTGTRHGQRQGQGHRTLSSGTGGLPYIAEASKVAPKDA
                     KALSRPFFERLAVLEEGTHAYQYVRNTLVEMNLSLVRYAAARFRNRGGDPSEMEDIVQV
                     GTIGLIKAIDRFDLSREVEFTTFAVPYIVGEIKRFFRDATWAVHVPRRLQELRIDIAQA
                     KERLFARLDRDPTVAELAEHLGLGEDEVIDGLIAGNGYTAGSLDQPCDPAEDESARSLA
                     DALGDEDPRLQLAEDLHALTPLVRKLDRRDRRILTLRFVHEKTQSEIGEELGVSQMHVS
                     RLLARILGRLRTGLIGQP"
     gene            complement(7911..8498)
                     /locus_tag="AOB60_RS23965"
                     /old_locus_tag="AOB60_23025"
     CDS             complement(7911..8498)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016639027.1"
                     /locus_tag="AOB60_RS23965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_23025"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_102924984.1"
                     /transl_table=11
                     /translation="MPESRQRADAVRSREAVLDAAEALFARSGPAEVSMNAVASAAGVG
                     KGTVFRAFTDRAGLLQALAERRTAALRRAVAEGPAPLGPDAPPHERIPAVLDALARFKL
                     DNQSLYLVLEEAGAASPYRSPSYTWWHTTLRDSLAQCADAGRADFVAHALLAAVRADLI
                     AHLLTVEGLSVDEIRDRLAVYVRSVLPRDTHV"
     misc_feature    complement(8514..8526)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.65"
                     /tool="antismash"
     gene            8611..9030
                     /locus_tag="AOB60_RS23970"
                     /old_locus_tag="AOB60_23030"
     CDS             8611..9030
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047605.1"
                     /locus_tag="AOB60_RS23970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_23030"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_102924985.1"
                     /transl_table=11
                     /translation="MTPATTAQRTPEDLFRHGLRLLLDQDFAAWVDLWDDQGVFEFPFA
                     PEGRPRRLEGRSAVAAYMRDYPDHIELHDFPHLTIHQTQDAGTIIAEMSAVGRLVATDE
                     PFAMSYVAVVTVANGRITHYRDYWNPLAVPASMRS"
     gene            9077..9952
                     /locus_tag="AOB60_RS23975"
                     /old_locus_tag="AOB60_23035"
     CDS             9077..9952
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324534.1"
                     /locus_tag="AOB60_RS23975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_23035"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_102924986.1"
                     /transl_table=11
                     /translation="MTTPHHTPPTTGPVLVTGATGTTGSRLVARLTRAGLPTRAAGRHP
                     VPVTGAEPVAFDWTDPATHDAALDGASAVYLVPPPGATDAAAVMLPFLDRARRAGVRRA
                     VLLSSSLIPAGGPATGTVHQALPGLVPEWAVLRPSWFMQNFTGHHPHADAIRTDGLLTT
                     ATGRGRVAFIDADDIAAVATHALTDPVPHNTDWVLTGPAALSYDAVAAILTEVSGRPVR
                     HRAVSEAELRTRLAQHLPADFAAILADLDRRIADDAEDRVTDAVTRVTGRPPRSFAAYV
                     RANVQSFTGL"
     gene            complement(10001..11050)
                     /locus_tag="AOB60_RS23980"
                     /old_locus_tag="AOB60_23040"
     CDS             complement(10001..11050)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     atropopeptide: atropopeptide_p450"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145092.1"
                     /locus_tag="AOB60_RS23980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_23040"
                     /product="cytochrome P450"
                     /protein_id="WP_102924987.1"
                     /sec_met_domain="atropopeptide_p450 (E-value: 6.5e-179,
                     bitscore: 591.9, seeds: 287, tool: rule-based-clusters)"
                     /sec_met_domain="p450 (E-value: 1.8e-12, bitscore: 44.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQRPTVTRGDRRVRFAPRIDALLHRHTGQELFRLEPTTIGVAGA
                     DLMDALLRSRPANAEERPTFKPVLGRHVGRADAAAYMQALGADVRKALQHPLETSVDLT
                     GAWPAVPHTYLRDLVFGQELGRLRILVDRRLELTPKLTWSAVASGAALLRRPDPAEPLS
                     KLATLALGAAGYADRRYALYLYRRVAAPICFTVAALVTNAVWLGAPFDDAVPNRQLLAE
                     ALRLLPPSWNILRMASPELTAVDDRIGPTDDVLLLPLLSHRDPALWEDPDAFRPERWAD
                     LDPDNHPGYLPFGHANERCWARHMVLPLAERILDLVRRDGLTVRPAQTAGRVELDGLME
                     VAEVRVTRG"
     misc_feature    11086..11104
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.15"
                     /tool="antismash"
     misc_feature    complement(11386..11405)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.23"
                     /tool="antismash"
     gene            complement(11660..12643)
                     /locus_tag="AOB60_RS23985"
                     /old_locus_tag="AOB60_23045"
     CDS             complement(11660..12643)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016575931.1"
                     /locus_tag="AOB60_RS23985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_23045"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_102924988.1"
                     /transl_table=11
                     /translation="MRADRLLALLLLLQNRGRMTAAELAAELEVSVRTIYRDIEALGAS
                     GVPVRTERGPDGGYRLMDGYRTRLTGLTGAEADALFFAGAPGPARDLGLGAVLATAQLK
                     VQAALPVELAERTRRIQDRFHLDAPAWFRDADPVAHLAPVARAVWEQRVVRTHYRRWRG
                     EVHRELRPLGIVLKGGIWYVVALADEAVRTYRIARFQAVELTDEAFERPAGFDLAAYWA
                     ESSRRLAAALHQDTAHLRISPQARRLLPMLYGAVGRRALEGAGEPDADGWTEVTMPVEG
                     PAVAVGDLLRLGAEAEVLGPPALRRAVAETVAVLAGRYATVDDPSE"
     gene            12746..13153
                     /locus_tag="AOB60_RS23990"
                     /old_locus_tag="AOB60_23050"
     CDS             12746..13153
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016575932.1"
                     /locus_tag="AOB60_RS23990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_23050"
                     /product="DUF3224 domain-containing protein"
                     /protein_id="WP_102924989.1"
                     /transl_table=11
                     /translation="MPAQTTGRISYANWAEQPIGSDATSPRLARACVTNNFSGGIEADR
                     TACEYTIVYTSDKTGTFTGLELLTGRLDGREGSFVLEERGAFDADGTVRCTFEVVPGSA
                     TGDLVGLSGSGSFRYEAGNPSFPYTFDYRMG"
     gene            complement(13274..15076)
                     /locus_tag="AOB60_RS23995"
                     /old_locus_tag="AOB60_23055"
     CDS             complement(13274..15076)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537609.1"
                     /locus_tag="AOB60_RS23995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_23055"
                     /product="coagulation factor 5/8 type domain-containing
                     protein"
                     /protein_id="WP_102924990.1"
                     /transl_table=11
                     /translation="MTPASKESPTPERPTVGRRTVLGAAAAVASAPALLGPARTAHAAP
                     PHRTPGALPGGGDLGPNVLVFDPATPGIQAKLDEVFKQQEKAQFDTGRYALLFKPGTYH
                     GLNAQLGFYTSIAGLGLSPDDTTINGDVTVDAGWFNGNATQNFWRSAENLALVPVNGTN
                     RWAVAQAAPFRRMHVRGGLNLAPAGDGWASGGYLADSRIDGTVEPRSQQQWYARDSAVG
                     GWSNGVWNMVFSGVQGAPGQTFPNPPYTVLDTTPLSREKPFLHLDGADYRVFLPELRTN
                     ARGVTWGNGTPRGTSLPLSQFYVAKPGVSAATLNEALAQGLHLLLTPGIYHLDQPIQVT
                     APNTVVLGLGYATLIPDNGVTAVRTADVDGIRLASFLIDAGPVNSATLLEIGPAGAAAD
                     HSANPTTVQDVFLRIGGAGPGKATTSIVVNSRHTIIDHTWVWRADHGDGVGWDTNRADY
                     GIRVNGDDVLATGLFVEHFNKYDVQWYGQRGRTVFLQNEKAYDAPDQSAVQDGDVKGYA
                     AYKVADSVTSHEAWGLGSYCYYNVDPSIVQHHGFAAPNAPGVKFHDLLVVSLGGKGQFE
                     RVINDTGAPTSGSSTVPSTVVAYP"
     gene            complement(15401..15952)
                     /locus_tag="AOB60_RS24000"
                     /old_locus_tag="AOB60_23060"
     CDS             complement(15401..15952)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537610.1"
                     /locus_tag="AOB60_RS24000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_23060"
                     /product="hypothetical protein"
                     /protein_id="WP_102924991.1"
                     /transl_table=11
                     /translation="MAATRNRAIPALAVALALQAGVAGVATAQAVPAVASAPAAAPAAA
                     IRITEGQVGEVGPGRTIVYPAVTSCLTVTVRLADGGKVGAHASLFQVPGEYRSDRILAA
                     VQQRIGTRAVRAVEVRGAVGAWHPSYFTRAIESYPEGAQIPVPTAPDPDGLARAVADGL
                     GQPRGKVTVQDLPDGDQTVE"
     gene            complement(15967..16587)
                     /locus_tag="AOB60_RS24005"
                     /old_locus_tag="AOB60_23065"
     CDS             complement(15967..16587)
                     /EC_number="2.7.7.87"
                     /GO_function="GO:0061710 - L-threonylcarbamoyladenylate
                     synthase [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004059.1"
                     /locus_tag="AOB60_RS24005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_23065"
                     /product="L-threonylcarbamoyladenylate synthase"
                     /protein_id="WP_102924992.1"
                     /transl_table=11
                     /translation="MAKYFDVHPDNPQRRTITTVADTVRSGGLIAYPTDSCFALGCRLG
                     SRDGIDRIRSIRALDDRHHFTLVCQNFSQLGQFVQIDNDVFRAIKAATPGRYTFILPAT
                     KEVPRQLLHPKKKTVGVRIPDHTVTQALLEELGEPLLSSTLLLPDEDEPLTQGWEIKER
                     LDHVVDAVVDSGDCGTEPTTVVDFSGGVVEIVRRGAGDASRFE"
     misc_feature    16712..16727
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 24.4"
                     /tool="antismash"
     gene            16752..17999
                     /locus_tag="AOB60_RS24010"
                     /old_locus_tag="AOB60_23070"
     CDS             16752..17999
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014142647.1"
                     /locus_tag="AOB60_RS24010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_23070"
                     /product="chitinase"
                     /protein_id="WP_102924993.1"
                     /transl_table=11
                     /translation="MPPRHVRTLAAAVSAACIALGVAGTALATGQRAAPRPAAATPAPK
                     ALGGNWYAAAPYLMPLDNDPPDAGAVMDATGLKAFQLAFVLAPNGGGCSPTWDGLHPVA
                     SDTAVAGVISAIRAKGGDVSASIGGYNGTKLGQACGTPEATAAAYQQVIDKYGLKALDF
                     DLEEPEYENSAAIHNEIGAAKILQQKNPGLYLSVTTAGTADGTGWFGKQMLNEAKSQSF
                     VPDNFSIMPFDGGFNGAAAQTSALTNFNAVLRSTFGWDEATAYAHEGISQMNGRSDTGE
                     FFTQADFQTVLDYATSHHMARFTNWSVNRDRQCTPPDNNGRTSGTCSSVPQGAWDFTKY
                     SVKFAGATPPTTPPTTPPTTPPGGSCAASPYTAGTVYVGGDTVSYNGHTWKARWWTQGE
                     APSTGGSGVWQDLGTC"
     gene            18108..19052
                     /locus_tag="AOB60_RS24015"
                     /old_locus_tag="AOB60_23075"
     CDS             18108..19052
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158: ornithine cyclodeaminase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537613.1"
                     /locus_tag="AOB60_RS24015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AOB60_23075"
                     /product="ornithine cyclodeaminase"
                     /protein_id="WP_102924994.1"
                     /transl_table=11
                     /translation="MSATPPVPHLPRTIDETGLLRALPMAAAVDALRAALRDGPDPEAD
                     PPRTIVPVEHGQLLLMPAHRSRYAGVKIATVAPDNPAAGLPRVQGQYLLFDAPTLAPLA
                     LLDGIALTTVRTAAVSALAADLLAVPEASRLVVFGTGPQARGHLDALRAVRPLTHVTVV
                     GRTPANVERFVATARRDTGLRVEAGEPSAVAGADLVACCTTARAPLFDGALLPPHAMVT
                     AVGSHERGSREVDGTTVLRSTVVVESRSAAAREAGDLIPELESGRLDREALVTLAGLAT
                     GAATVDPDRPRLFKSVGMAWEDLAVAGAAYEAT"
ORIGIN
        1 ccaccgcggc gacccgggcg atcgtccgga aaatcatcaa ggaggccgcg aagcaggtcc
       61 tcgacgcagc gctggaaacc gccaaggagc ccgcggtctc ggcgctccag gccatgatct
      121 cggacgtcat cgcacagtcc gtgaacatga gcttcggcgc ccagaacgga ttcgacgtcg
      181 gccggaccgt caacaagggc gccgaggaag gcgtcaacgc gctcaagaac tcggggcaga
      241 cgttcaccga ggcgttgcgc gatggcgcgg gcgccaaggc aggccaccac gtccgcaacg
      301 gcctggaatc ggccgccggc cacaactccg gcggcgactc ggccggcggt tcgggacatg
      361 agtccacagg cggcgggagc gggggcggaa acacctcctc aggatccggc acttcgggcg
      421 gcggccagtc gtcgtccggg ggcaaccact cgccgtcgag cggcagcaac tcaccgtcgg
      481 acggcggtag ttcatcgccc ggaggcagcg gatccccatc gggaggcgac ggatcaccgt
      541 ccacgggtgg gacatcggcg ggtggatcgt ccgcgggcgg aacgtcagct ggcgcatcgt
      601 cggcgggcgg tggagccacc gcatcggggg gatcatcgtc ggcagaccat tccaccccca
      661 cgaacaaccc ctcaacggcg ccgaactcct ctccccacgg cgggagttca cccgccgatg
      721 gcggaagttc ctcctcggcc ggaggcaatg gtcactcgcc ggacggcggt aactcgcccc
      781 gcccggcgca ttccgccacc ccgccgcaga gccagctgac gccgttcgac gcgggttacc
      841 gggaagcaca gacggcatcg cccacgcctg acgcctcgtc gtccgctacc tcttccccgt
      901 cgtccccgga ctcgtccgcc cgaccgaaca ccgatacacc cacctcccac gacaccagca
      961 acaacggcag caacaccgac accagcacca acgccgcccc acgcccggac tccgaaacgt
     1021 ccccgcgatc cgacaccgac gcgcccccgc gaccgcacac ggagtccacc gcggacaccg
     1081 gcaccaggac ggacaccgac agcaggccag ataccgcatc agcaccggca ccgacacccg
     1141 cccacgcaga cagccccagc cccaacccaa gccccaaccc cgctgccccc actccggaac
     1201 atcacagcaa cgggatcagc gaccccagcg gcggcagtgg cgacactggc gacactggcg
     1261 gcgttggcaa cactggcggc agcgccacca acagtgggaa cgacggcacc actgacaccg
     1321 gtacccatac gcgcccgcaa ccacagcacg cgccatcacc agcccctgac ccatctccct
     1381 ccccttcccc ctccccgacc ccgtctccga cgccggacca ctccggcacc cagcacgacg
     1441 acggcaacag cagcaacggc gggggcagcc gtaccagcat gccgacgggc ggtggagtgg
     1501 catcgggcgg cagcgctccc catgcggccc cgtccggaca cgggtactcc ggtccctcct
     1561 cgtccggtgc gccgcaccag cccgatccca accggcccca ggacgacggc ccggtcaccg
     1621 tgcacacgga gagcgcgacc ctggcacctc caccgccggg cgtcgcccag ccgtcgcatg
     1681 caggcggcga tacccccggt tcggccggca caccgccgcc gtctacacag caatcgccgc
     1741 agcccggcgt cgtcatgggc ggcggcacca tgcctacggg cgttcccgcc gggactcccg
     1801 cgggcggatc cccctccgct acgacacccc cgcggtcgac cgccccatcc tcccccgccg
     1861 gcaacgccgg cgcacccccg cgcggcacgc cgacccggga cccgcggaac cccaccgcgg
     1921 ccgaccagtc gtcgcgcccg cggcccacgc ctgcgcgtag caccgcccaa ccgccgcgca
     1981 ccgagcgtcc gcacggcgag caaccgtccc cgcgtccgtc ccggcccgca cagcaatcgc
     2041 cccacaccaa cgacgcaccg ccgtcgccca ccacccctga ccacaactca cagtcgccga
     2101 acaccaagca cgacccgaag cccgacagcg actccaagcc cgagaacgac tccaagccgg
     2161 acagcgagtc gcaccccaag gacgaccaag cgccggacaa caaggacgac acttcccaca
     2221 cgcccgaccc atctgacgtg cctgacgcgt ctgacgcacc tgacacctcc gacgccaccg
     2281 ccacaccgga cgaccgtccc agcctcgacg agatccggtc cggtatccag gagtcccccg
     2341 gcggcctgct gccgcccgac accgtggacc agcacgcgct ggagaacgcc gtcccgcgca
     2401 acgacgacgg cagcccacag cgcttccccg atccgacggc cggctgggcc cagttgcaga
     2461 acgacggcgg caccaacgtg ccgggccgtt ccaacaactg cgccgactgc agtcgttcgt
     2521 tcctggagac ctggtacggc aacccccagg tctccgcgcc ccggaccccg gaccagaccc
     2581 cggacgggac cccggaccac tggtcgccgg agtccaaggc caacgagaac atcatcgact
     2641 gggccggggc gccgcactcc tacgccggca ccagcccgga cgggcaccat gccatcgccc
     2701 aggagttgct gaaggcaggg ccgggctccg cggcgatcgt ccaggtcaac tgggcggacg
     2761 gcggcggtca tgcgttcaac gccgtcaacc acaacgggaa gatcgtctgg gtcgacaccc
     2821 agagcggtga ggtcagccac caccccatca acaccgaggg cgccacggac gtcttccaca
     2881 tcccgctgga cgccgaccgg acgccgctgc atcccgcccc ggatgcctcc aacggttccg
     2941 gtgccaccga ttcgcaccac aattccgacg gcacggaccc cgaccacact gcgcacgcgg
     3001 accagtcgcc ccctgcggcg aacggttccc acgacacggg cgtcggcacc gcgagccacg
     3061 acgcaccgag tccggaccac gggaaggacg agcggccttc ggcggccgac cccgccgccc
     3121 tcaagcgcaa ggccagcgaa cagccttcgc ctgacggtga gtccgtcagc tcgacccccg
     3181 agtccgggtc cgatgcccac cggcggaccc gaataaaggt ggacggggag ggacagccgg
     3241 gccagcagtc tggtaatgat ccccacaccg acaccccgtc accgccccag acaaccctcg
     3301 gttccctccc ggaccacatg gacgccctgg gcctcgacga ccaccgcatg gacgtcgatg
     3361 acgaccacac gcagcagcat tcaccgccac agcaggcacc gcagccccag gggacgaaca
     3421 ccggctccgg cacggcggag catcccacct ccgggccgcc gcacggcaag acggacagca
     3481 agacagacgg caagacggac ggcaaagagc cctactccga tccccgtgat cgcggcacga
     3541 gcgacaccgc caagcaggag aaggagggga agcacaccct cgacgcggag aagaaggatt
     3601 ccaaggagta cgggaaggtt ccggacaagc tccaggcgca gctccgcaac gatcgggacg
     3661 tgcaccgcat cccgctcgac cgggtccacg accggctgac cggctgggcg gacgacggaa
     3721 gtttggcacg ggcgctccgg gcctcttccg gccatccgca gaccaacgac cccgacgcgg
     3781 gcaagggacc gcagaaattc acccagagcg acctggagaa gcggctgccc ggattcaagg
     3841 acctggaccg cggtgagaaa ctcgccgtcg tctcgtccct gacccggctc agtgtgggat
     3901 tccacgagca gcacggtgtc ggcagcaatc cggtggacgt cgacaagccg taccgtcctc
     3961 cgaacgagcc ggatgccaag gacggcacca cggacagtgc cgccaagaac tccgacgagt
     4021 cactgggcgt ccgagggcac cgcaacagcg gcaacaaata cctcgacaag ctgaagcacg
     4081 acggtccgat gccggagagc ctgaagcaga acagtccgga cttcaccgac cgcaactacg
     4141 cggtgttgga ggtcgaaggg ccgccgcccg cgcgggaaac ccactacgtt gccgattcct
     4201 cggttccggt gggcgagaag tacgtgtcgg gacgccactc ggagaaacat ctcatggagt
     4261 ggcttaatcg ggccaatcaa gagggcgcgc aatacagcgc gaaggccctt tacaccgagc
     4321 gcgaaccgtg cggcaacggc caggggcacg cgaagtgttc gaacgtgctg agggagatga
     4381 ctcctaaaga cacgaaggtg tactacagca cgacctaccg aaccgacccg gaagacgtca
     4441 aggcgaagaa gcagctcgac acggagaaga agaagctgaa gaaggagttc gacaagaagc
     4501 ccatcgtcgg cgtgcagaag gagatcaacg accggctcga tcgccgcgag ggcaagagcg
     4561 cgcattggat cgcggcagag aaggacaaga tcgacaagct cagcgaggcg gaacagcgca
     4621 agaagctctc ggacatgatc gatgcggagt tcaccaagcg gaagaacggg atgacgacgc
     4681 ccgaaaagca ggcgatggtc cgcgaaatgg accggcatat cgcccatctt gactcgacct
     4741 ggaagaagat tcagccgagt ctgctgtagt gggcagcgcc gacgcactcc gcgagtgccg
     4801 ccgccggcct tctgtcacgg cggcggcacc gcctcggggc gccctcagat gtccagggcg
     4861 ccccggaacc ggccgtgccc aacgttcggg tcggtcaccg cgagccagcc gtgcccgacc
     4921 cggtcgagca cctcgaccac ggtcggctgg atggaaatcg aggaagcgac ctcctccgga
     4981 ccacggacgc cctcggcgta ctgctcggcg tcgtcgtcct cgtcgtcgta ggcgtcgccg
     5041 cccggcatca agttccgctc gaattccatc ggttccccga tccactccgg gtcgccgtag
     5101 gtgcggtagc cgcgcttgtc gtgtccgttc tccgaaaccc accacacttg cgcgccgttg
     5161 tagtcgtcga tggcgtagaa gtgggcttcc cggcagtgcg cgctgagccg tgtcacgatc
     5221 tgcgcccagt tgtcgttgag gtaatcggcg ccgtagatca gtcgccagcc gtcgaattcc
     5281 ggggtgatga agacccggta tgccgtggtg acgccaccgt cttccgtggg gcgccggagg
     5341 gaattctcgt gctcgacggc ggcggacaga cccatggccg tcgtgaccgg gcggacgtcg
     5401 tgcaggtcca acgcccggac gatatcgccg atttccgcct cgggcaccgc gatccagcag
     5461 tcggcgggca gatcacccgg ctcctcgtcc ggcattttga tctgcaccaa ccgctccacg
     5521 gccgcccgat ccgcgtcact gagggcatcg gcaccgccga tcgtggccag catgcgcagc
     5581 gcggccttcc gcaggcttcc gggaccctcc gcgcgcacct cgcggagcgg accgattgcc
     5641 gcgtgcccca ggctttccag acaggattcc gcggccgagt tgcccggcgt ttcttcattg
     5701 cgcagcagcg gcagcaggtg tttgacgacc ggggccccga gagcggccag tgcgtcctgt
     5761 gcggccgcgc gatcctcccg gctctcggaa gccagacgac gtaccagtgc ggcgatctcc
     5821 tcactcatgc gtccgaccct aaccgagcgg tccgggcgac ttccgccatc ggccggaaag
     5881 gccggagtgc gctcatctcg acagccggcg caccgtcccc cgccaacgcc aactcctcgt
     5941 agaaatccac gttccgaccc acgtcggctc cagttttccc cacccgctcc ccacacccac
     6001 ccggcccgtt cccggcgaat tccgcggagg tccgtgaaac ggtgcggagg agtcgcggtc
     6061 agcgaagggc aaggacgccg atcgggcacc cttcgaacca gcaaagaagg gccacttttg
     6121 ccccattacg ctacattctc tccatgtcca acgaaccgat gcgcctgcca gatctctcct
     6181 cccggccgca ccagctcgcc gtcgaacgac tcatgagcgg aacgccggcc gcgctgtacc
     6241 gggcctggac cgagcagttc gaccgctggt tcgcggccgc cggatcggtg ctgatggagg
     6301 gccgggtgaa cacggcgttc ttcttcgaga cggagcacga gggggcccgc cacccgcact
     6361 acggccgctt cctgcggctc gatccggatc gactggtcga gctgacgtgg gtcaccggcg
     6421 cgggcggaac ccagggcgcg gagaccgtgg tcacggtcgc attcgccgcc gaggactccg
     6481 ggacgcggct acggctcagc catgccgggt tcgccgacga ggcggcgcgc gaccgccacc
     6541 gggacgcatg gccgcacgtc ctggaacagc tcgaccggcg catcggggct gcgcactgac
     6601 gcccgcgacc gggccgagaa ggaccctgag cgagccgagg agagaccaca gaaaggccaa
     6661 ggaaaggcca aggaaaggcc gaggaagggc cacgggaaga ccgaaccgag cgcgagacga
     6721 aggccgcgat gcgtccgatg cccggaagag agcagtacgt attgccacac cacacctgct
     6781 gacgcaacgt caagatcctg gatggcaaaa aagatggggc tggtgttttg ttccgcgaac
     6841 gaagggcaga cgcggcttac cggaccatga tccaaattat gggagggcag ccatgacgac
     6901 ggcagtttcc acacacaccg gaacgcggca cggccagcgc cagggacagg gccaccggac
     6961 gttgagttcc ggaaccggcg gactgccgta catcgcggag gcgtccaagg tggcaccgaa
     7021 ggacgccaag gcgctgtccc ggccgttctt cgagcggctc gcggtactgg aggagggcac
     7081 ccacgcgtac cagtacgtgc gcaacacgct cgtcgagatg aacctctccc tcgtccgata
     7141 cgccgccgcc cggttccgca accgcggtgg cgatccgagc gagatggagg acatcgtcca
     7201 ggtcggcacc atcgggctga tcaaggccat cgaccgcttc gacctgtccc gcgaggtcga
     7261 gttcacgacg ttcgcggtgc cctacatcgt gggcgagatc aagcggttct tccgggacgc
     7321 cacctgggcg gtccacgtac cgcggcggtt gcaggagctg cggatcgaca tcgcccaggc
     7381 aaaggagcgc ctcttcgccc gcctggaccg ggaccccacg gtcgccgaac tcgccgagca
     7441 cctcggcctg ggcgaggacg aggtgatcga cgggctgatc gccggcaacg gctacaccgc
     7501 ggggtcgctg gaccagccct gcgacccggc cgaggacgag tcggcccgca gcctggccga
     7561 cgccctcggc gacgaggacc cgcggctgca gctcgccgag gacctccatg cgctgactcc
     7621 cctggtccgg aagctcgatc ggcgggatcg ccggatcctc accctgcggt tcgtccacga
     7681 gaagacgcag tcggagatcg gcgaggagct cggggtgtca cagatgcatg tctcccggct
     7741 gctcgcccgg atcctgggcc ggttgcggac gggcctgatc ggccagccgt gacgtgacgg
     7801 ccagccacgc caggggccgg cggtcggccg tcaggccatg gccggacggc cggccggtcg
     7861 ggacctcggg acccgatggg ccgccggccg cgaccccgac cgggggcgcc tcacacgtgc
     7921 gtgtcgcgcg gcagcacgga gcggacgtag acggccagtc ggtcgcggat ctcgtcgacc
     7981 gacagcccct ccacggtgag caggtgcgcg atgaggtcgg cgcggacggc ggccagcagg
     8041 gcatgggcga cgaagtcggc gcgcccggcg tcggcgcact gcgccaggct gtcgcgcagc
     8101 gtcgtgtgcc accaggtgta ggacgggctc cggtacgggc tggccgcgcc ggcttcctcc
     8161 aggacgaggt agaggctctg gttgtccagc ttgaagcggg ccagggcgtc gagcaccgcg
     8221 gggatccgct cgtgcggcgg ggcgtcgggc cccagcgggg cgggtccttc ggcgacggcc
     8281 cggcggagcg ccgcggtgcg tcgttcggcg agcgcctgga gcagtcccgc ccggtcggtg
     8341 aaggcccgga agaccgttcc cttgccgacg ccggcggccg acgcgacggc gttcatgctc
     8401 acctcggcgg gaccgctgcg cgcgaacagc gcctcggcgg catccagaac ggcttcacga
     8461 ctgcggacgg cgtccgcacg ctgtcgggac tcgggcatcg gtcatgacct ctcttgcaaa
     8521 acggaccacc ggtccgtatc gtcgaagcgg accggcggtc caaccgtatc ggacgaccgc
     8581 gccgcacgct cccgatcgag gagaagcgag atgacccccg ccacgaccgc ccaacggact
     8641 ccggaggacc tcttccgtca cgggctccgc ctccttctgg accaggattt cgccgcatgg
     8701 gtggacctct gggacgacca gggcgtcttc gagttcccct tcgcgcccga aggccgcccg
     8761 cgtcgcctgg agggcaggtc cgccgtcgcc gcctatatgc gcgactaccc cgatcacatc
     8821 gagctgcacg acttcccgca cctgacgatc catcaaaccc aggacgccgg cacgatcatc
     8881 gccgagatga gcgccgtggg ccgcctggtc gccaccgacg agccgttcgc gatgtcgtac
     8941 gtcgcggtgg tcaccgtcgc caacggccgc atcacccact accgcgacta ctggaatccc
     9001 ctggctgtcc cggcctccat gcgcagctga ccccgccccc tcccgcacac ccgcccatcc
     9061 cgtccggaag gtccccgtga ccacacccca ccacacgccc ccgaccaccg gccccgtcct
     9121 cgtcaccggc gccaccggca ccaccggcag ccgcctggtg gcccggctga cgcgggccgg
     9181 actccccacc agagccgccg gccgccaccc cgttcccgtc accggtgcgg aaccggtggc
     9241 cttcgactgg accgaccccg ccacccacga cgcggcgttg gacggcgcga gcgccgtcta
     9301 cctcgtgccg ccgcccggcg ccacggacgc cgccgccgtc atgctgccct tcctcgatcg
     9361 cgcccggcgc gccggagtgc gccgggcggt cctgctcagc tcctccctga tccccgcggg
     9421 cggtccggcc accggaaccg tccaccaggc cctgcccggc ctcgtcccgg agtgggccgt
     9481 gctgcgcccc tcatggttca tgcagaactt caccggccac cacccgcacg ccgacgccat
     9541 ccgcaccgac ggcctgctga ccacggcgac gggacggggc cgggtcgcgt tcatcgacgc
     9601 cgacgacatc gccgcggtgg ccacgcacgc gctgaccgac cccgtgcccc acaacaccga
     9661 ctgggtgctc accgggccgg cggccctctc ctacgacgcc gtcgccgcga tcctcaccga
     9721 ggtcagcggc cgaccggtac gccaccgggc ggtgtccgag gcggaactgc gcacgcggct
     9781 cgcgcagcat ctgccggcgg acttcgcggc gatcctcgcg gacctggacc gccgtatcgc
     9841 cgacgacgcc gaggaccggg tgaccgatgc cgtcacccgc gtcacagggc ggccaccccg
     9901 ttccttcgcc gcgtatgtgc gggccaacgt ccagtcattt acaggtcttt gatgatgcgt
     9961 cagccaaggt ctccgctggc tcgtagcggc gggacggggt tcagcctcgg gtcacccgga
    10021 cctccgcgac ctccatcaga ccgtcgagtt cgacccggcc ggcggtctgg gcgggacgca
    10081 ccgtgaggcc gtcccggcgc accaggtcca ggatgcgttc ggcgagcggg agcaccatgt
    10141 ggcgggccca gcagcgctcg ttggcgtggc cgaacggcag atatccgggg tggttgtccg
    10201 ggtccagatc cgcccagcgc tcgggccgga aggcatcggg gtcctcccac aacgccgggt
    10261 cgcgatggct cagcaggggc agcaggagga cgtcgtcggt cgggccgatc cggtcgtcca
    10321 cggcggtgag ttcgggcgag gccatccgca ggatgttcca cgacgggggc agcagccgga
    10381 gcgcctcggc gagcagttgc cggttcggga cggcgtcgtc gaacggggca cccagccaga
    10441 ccgcgttggt gaccaatgcg gctacggtga agcagatggg tgccgccacc cggcggtaga
    10501 ggtacagagc gtagcggcgg tcggcgtagc cggcggcgcc gagggcgagg gtggcgagct
    10561 tcgacagcgg ctccgccggg tcggggcggc gcagcagggc ggcacccgac gcgacggcgg
    10621 accaggtcag cttcggggtg agttccagcc tccggtcgac caggatccgc aggcggccga
    10681 gttcctgtcc gaagacgagg tcgcggaggt aggtgtgcgg caccgccggc caggcaccgg
    10741 tcagatcgac cgaggtctcc aaggggtgct gcagggcctt ccgcacgtcc gcgcccaggg
    10801 cctgcatgta ggcggcggcg tcggcccggc cgacgtgccg gccgaggacg ggcttgaagg
    10861 tggggcgctc ctcggcgttg gccggccggc tgcgcagcag ggcgtccatc aggtcggcgc
    10921 ccgcgacgcc gatcgtggtg ggctccagtc ggaacagctc ctgaccggtg tggcggtgca
    10981 gcagggcgtc gatcctgggc gcgaagcgca cccgccggtc gccgcgggtg acggtcggtc
    11041 gctgggacat cgggaacctc cgggaacgcg ggccggtggc ggaccgttgc gagcggcccg
    11101 ccaccgtccg ttgtgggcgt gggccgatca gatccagccg taccaggcgt acgccttgag
    11161 gctcttttcg gtgcgcatcc gcttcacgag acgaacgaac ttcatccgta cctccttggc
    11221 aggggctgac tgtgccccgt ggcaggccgc cgaaagggtc ttcgaccgcc gcagaagtga
    11281 atgccggggc ggttggggtg tcaagtggcc catatcacgc ggaaaaacaa ccaacccatg
    11341 tttcagggga gttcgcggtg cggagcgccg aaaagcgccg tacgaatagg gtggttggtc
    11401 ccaatgtagc ggatgttcat gccaaatgcc gtatagatag gcggcgttga cggatatgga
    11461 gaaggatcga agattttgtt gattttacgg agccgggcgg cccggccgcc ccgcggagcc
    11521 ggagcggggc gcgccaggaa ccccgacttc gacaccgcgc tccacaccac accttccgcc
    11581 agggcaccgg ccgcaagatc cagctcagtc cgcagagctg aactcccgtg cggatcagct
    11641 cggtcctgtg cggagcgggt cactccgacg ggtcgtccac cgtcgcgtag cggccggcca
    11701 ggacggccac cgtctccgcc acggcgcggc gcagcgcggg tgggccgagg acctccgctt
    11761 cagcgcccag ccggagcagg tcgccgacgg ccacggccgg cccctcgacc ggcatcgtca
    11821 cctccgtcca gccgtccgcg tccggctccc cggcgccctc caacgcccgc cgtcccaccg
    11881 cgccgtagag catcggcagc aggcgccggg cctgcgggga gatgcgcagg tgcgccgtgt
    11941 cctggtgcag cgcggcggcc aggcggcggg aggactcggc ccagtacgcg gccaggtcga
    12001 agccggccgg ccgttcgaac gcctcgtccg tgagctccac ggcctggaac cgtgcgatcc
    12061 ggtacgtccg caccgcctcg tcggcgagcg ccaccacgta ccagatgccg cccttgagga
    12121 cgatgccgag cgggcgcagc tcgcggtgga cctcgccgcg ccagcgccgg tagtgggtgc
    12181 ggaccacccg ctgctcccac accgcccggg cgaccggcgc gaggtgggcg accggatcgg
    12241 cgtcccggaa ccacgcgggt gcgtcgaggt ggaagcggtc ctggatccgc cgggtccgct
    12301 cggcgagttc gaccgggagc gccgcctgca ccttcagttg ggcggtcgcc agcaccgcac
    12361 ccagccccag gtcgcgggcc gggccgggtg ctccggcgaa gaagagcgca tcggcctcgg
    12421 caccggtgag cccggtcagt cgggtgcggt acccgtccat cagccggtag ccgccgtccg
    12481 gcccgcgctc ggtgcggacc gggacgccgg acgcgccgag cgcctcgatg tcgcggtaga
    12541 tcgtgcggac cgacacctcc agttccgcgg cgagttcggc ggcggtcatc cgcccgcggt
    12601 tctggagcag caggagcagg gcgaggagcc ggtcggcgcg catgctccga ttgtctcgcg
    12661 tacctgacag aaggtgtcag gtacggcggt caggatggct gcacaccgcc cggcaccggc
    12721 cgtgcgggag accgagagga cagccatgcc cgcacagacc accggccgca tcagctacgc
    12781 caactgggcc gagcagccga tcggttcgga cgcgacgagc ccgcggctcg cacgcgcctg
    12841 tgtcaccaac aacttctccg gcggcatcga ggccgatcgc acggcctgcg agtacaccat
    12901 cgtctacacc tcggacaaga ccgggacgtt caccggtctg gagctgctga ccgggcggtt
    12961 ggacgggcgg gagggcagtt tcgtgctcga agagcgcggc gcgttcgacg cggacggcac
    13021 ggtgcgttgc accttcgagg tcgtccccgg atcggccacc ggggacctgg tcggcctgag
    13081 cgggtcgggc agtttcaggt acgaggccgg caatccgtcc ttcccgtaca ccttcgacta
    13141 ccggatgggc tgagcgccgc ccgtcgtcag tggcggacga ggagttcggc gccgcgcccg
    13201 aagccgaccg accgtgccat ggcctcctgc catggcacgg cgggccgggt ggtggtacgg
    13261 gccgggccgg aggtcagggg tacgccacca cggtcgaggg aaccgtcgag ctgcccgagg
    13321 tcggcgcgcc ggtgtcgttg atgacgcgtt cgaactggcc cttgccgccg agcgagacga
    13381 ccagcaggtc gtggaacttc acccccgggg cgttcggggc ggcgaagcca tggtgctgga
    13441 cgatgctggg atcgacgttg tagtagcagt agctgccgag cccccacgcc tcgtgggagg
    13501 tgaccgagtc ggcgaccttg taggcggcgt agcccttgac gtccccgtcc tggacggctg
    13561 actggtcggg ggcgtcgtac gccttctcgt tctggaggaa gacggtgcgg ccccgctgtc
    13621 cgtaccactg cacgtcgtac ttgttgaagt gctcgacgaa caggccggtg gccaggacgt
    13681 cgtcgccgtt gacacggatg ccgtagtcgg cacggttggt gtcccagccg acgccgtcgc
    13741 cgtggtctgc gcgccagacc caggtgtggt cgatgatggt gtgccggctg ttgacgacga
    13801 tgctggtggt ggccttgccc gggcccgcgc cgccgatgcg gaggaacacg tcctggacgg
    13861 tggtcgggtt ggcggagtgg tccgcggcgg cgccggccgg gccgatttcg agaagggtgg
    13921 cggagttcac cgggccggcg tcgatgagga agctagccag tcggatgccg tcgacgtcgg
    13981 cggtccgtac ggcggtgaca ccgttgtcag ggatgagtgt ggcgtagccg aggcccagga
    14041 cgacggtgtt gggcgcggtc acctggatcg gctggtcgag gtggtagatg cccggggtga
    14101 gcaacaggtg gagcccctgc gcgagcgcct cgttgagggt ggcggcggag acgccgggct
    14161 tggcgacgta gaactgcgac aggggcagcg aggtaccgcg cggggtgccg ttgccccagg
    14221 tgacaccgcg ggcgttggtg cgcagctccg gcaggaagac ccggtagtcg gcgccgtcga
    14281 ggtggaggaa gggcttctcg cgggagaggg gggtggtgtc gagcacggtg tagggcgggt
    14341 tggggaacgt ctgccccggg gcgccctgca cgcccgagaa caccatgttc cacacgccgt
    14401 tggaccatcc gccgaccgcg ctgtcgcggg cgtaccactg ctgttgggaa cgcggctcca
    14461 cggtcccgtc gatgcggctg tcggcgaggt agccgccgct ggcccaacca tcccctgcgg
    14521 gcgccaggtt gaggccgccg cggacgtgca tccggcggaa cggcgcggcc tgggcgacgg
    14581 cccagcggtt ggtgccattg accgggacga gggcgaggtt ctcggcggag cgccagaagt
    14641 tctgggtggc attgccgttg aaccagccgg cgtcgacggt gacgtcgccg ttgatggtgg
    14701 tgtcgtcggg tgacagtccc aggccggcta tggaggtgta gaagccgagt tgggcgttga
    14761 ggccgtggta ggtgccgggc ttgaacagca gggcgtagcg cccggtgtcg aactgggcct
    14821 tctcctgctg cttgaacacc tcgtccagct tcgcctggat gccgggggtg gccgggtcga
    14881 agacgaggac gttggggccg aggtcgccgc cgccgggcag ggcacccggg gttctgtgcg
    14941 gcggcgcggc gtgggcggtc cgggcggggc cgagcagggc gggggccgag gccaccgcgg
    15001 cggcggcgcc gaggacggtg cggcggccga cggtgggacg ttcgggcgtg ggggattcct
    15061 tggaggcagg ggtcatgggt gactctcctg attcaggaag tgaagatgtg gggggtgggg
    15121 agcgtactcc cgccgtcgca tgcttcagct tcgtgaaggg tgcgtcaaga gccccgaccc
    15181 gagtttcgcg cgacgacacc gaccgaccgt caacacatgt gctgataggg gcagttggtg
    15241 ccgctacgcg cttctgtgcg gcacggggga cttgccccca ccgcgttcaa gaagtgtccg
    15301 acctccggtg cccggcctcc actgtccgac caccggactc caggctccag gcgacgacct
    15361 cagggctccg aactccgggc tccgggctcc gggctccgat tcactccacc gtctggtccc
    15421 cgtcggggag gtcctgcacg gtgaccttgc cgcgcggctg gccgaggccg tccgccaccg
    15481 cccgggccag gccgtcgggg tcgggcgcgg tgggcaccgg gatctgtgcg ccctccgggt
    15541 agctctcgat cgccctggtg aagtagctgg gatgccaggc accgaccgcg ccccgcactt
    15601 ccacggcgcg taccgcccgc gtcccgatcc gctgctggac cgcggcgagt atccggtcgg
    15661 accggtattc cccgggcacc tggaacaggc tggcgtgtgc gccgaccttc ccgccgtccg
    15721 ccagccggac ggtgaccgtc agacagctgg tgaccgcggg gtagacgatc gtgcggccgg
    15781 gcccgacctc gccgacctgc ccctcggtga tcctgatcgc ggcggccggg gccgcggcgg
    15841 gggcgctcgc caccgccggg accgcctggg ccgtggccac gccggccacg cccgcctgga
    15901 gcgccagcgc caccgcgagc gccggtatcg cgcggttccg tgttgctgcc atcgttccgc
    15961 cgccgctcac tcgaaccgcg aagcgtcccc ggcgccccgc cgcacgatct ccacgacgcc
    16021 gcccgagaag tcgacgacgg tggtgggttc ggtgccgcag tcgccggagt cgaccaccgc
    16081 gtccaccacg tggtcgaggc gctccttgat ctcccagccc tgggtcagcg gctcgtcctc
    16141 gtcaggcagc agcagggtgc tggagagcag cggttcaccc agctcctcca ggagcgcctg
    16201 ggtgacggtg tggtcgggga tccggacgcc gacggtcttc ttcttcgggt gcaggagctg
    16261 gcgcgggacc tccttcgtcg ccgggaggat gaaggtgtag cggccggggg tcgccgcctt
    16321 gatcgcgcgg aacacgtcgt tgtcgatctg cacgaactgg cccagctgcg agaagttctg
    16381 gcagacgagg gtgaagtggt gacggtcgtc gagggcgcgg atcgagcgga tgcggtcgat
    16441 gccgtcgcgg ctgcccagtc ggcaccccag ggcgaagcag gagtcggtcg ggtaggcgat
    16501 gagcccgccg gagcggacgg tgtcggcgac cgtggtgatg gtgcggcgct gggggttgtc
    16561 cgggtggacg tcgaagtact tggccatttt cgcgagtcta ggtgatcgtg cggccggtcg
    16621 gcgttcgccg cctcgacggc ccgcccgccg cgccgacttg gtccggtcca aagtgttgac
    16681 gtgcccacgg cgagggttca cgctgtggtc gattggtctg gaccaccccc tcgtcggctc
    16741 gtggaggtca agtgccacct cgtcacgtca gaaccctggc cgccgccgtc tcggcagcct
    16801 gtatcgcgct cggtgtcgcc ggcacggcgc tcgccaccgg ccagcgcgcc gccccgcggc
    16861 ccgccgccgc gacaccggca ccgaaggcgc tgggcggcaa ctggtacgcg gcggcgccgt
    16921 acctcatgcc gctcgacaac gacccgccgg acgccggcgc ggtgatggac gccaccggcc
    16981 tcaaggcgtt ccagctcgcc ttcgtcctgg cgcccaacgg cggcggctgc tcgccgacct
    17041 gggacggtct ccacccggtg gcgtcggaca ccgcggtggc cggggtgatc tccgcgatcc
    17101 gcgccaaggg cggcgacgtc tccgcgtcca tcggcggcta caacggcacc aagctggggc
    17161 aggcgtgcgg cacgcccgag gcgaccgccg ccgcctacca gcaggtcatc gacaagtacg
    17221 gcctgaaggc actcgacttc gacctggagg aaccggagta cgagaactcc gcggccatcc
    17281 acaacgagat cggcgccgcc aagatcctcc agcagaagaa ccccggcctc tatctctccg
    17341 tcaccaccgc cgggacggcc gacggcaccg gctggttcgg caagcagatg ctgaacgagg
    17401 ccaagtccca gtccttcgtg ccggacaact tctccatcat gccgttcgac ggcggcttca
    17461 acggcgccgc cgcccagacc tccgcgctga ccaacttcaa cgccgtcctg cgctccacct
    17521 tcggctggga cgaggccacc gcctacgccc acgagggcat ctcccagatg aacggccgca
    17581 gcgacaccgg ggagttcttc acccaggcgg acttccagac cgtgttggac tacgccacct
    17641 cccaccacat ggcgcgcttc accaactggt ccgtcaaccg cgaccgacag tgcaccccgc
    17701 cggacaacaa cggccggacc tccggcacct gcagcagcgt tccgcagggt gcctgggact
    17761 tcaccaagta ctcggtgaag ttcgccggcg ccacaccgcc caccacgccc ccgaccacgc
    17821 cgcccaccac gcccccgggc ggcagttgcg ccgccagccc ctataccgcg ggcaccgtct
    17881 acgtcggcgg cgacaccgtc tcctacaacg gccacacctg gaaggcccgg tggtggaccc
    17941 agggcgaggc gccgtccacc ggcggctcgg gggtctggca ggacctgggc acctgctgac
    18001 cccgtgggga gcagcgctcc ggcgggcgct cctcccctcc ccgccccgca cgtccggtgc
    18061 gtcgaagatc acgcatcctg gcagccggcc ggggcagact cggcggtatg agcgccacgc
    18121 ccccagtccc ccacctgccc cggaccatcg acgagaccgg cctgctgcgc gccctcccga
    18181 tggccgcggc cgtcgacgca ctgcgcgccg cgctgcgcga cgggccggac cccgaagccg
    18241 acccaccccg caccatcgtg cccgtcgagc acggccaact gctcctgatg cccgcgcacc
    18301 gcagccggta cgcgggcgtc aagatcgcca ccgtcgcccc cgacaacccg gccgccggac
    18361 tcccccgcgt gcagggccag tacctgctct tcgacgcccc caccctcgcc ccgctcgcgc
    18421 tgctcgacgg catcgcgctg accaccgtgc gcaccgccgc cgtctccgcc ctcgccgccg
    18481 acctgctcgc cgtccccgag gcgagccgcc tggtggtgtt cggcaccggt ccccaggccc
    18541 gcggccacct ggacgcactg cgcgcggtgc gtccgctgac ccatgtcacc gtggtggggc
    18601 ggacccccgc caacgtcgag cggttcgtcg cgacggcccg ccgggacacc ggcctgcgcg
    18661 tcgaggccgg cgagccgtcc gcggtcgccg gcgccgacct cgtcgcctgc tgcaccaccg
    18721 cccgcgcccc gctgttcgac ggcgccctgc tcccgccgca cgccatggtg accgcggtcg
    18781 gctcccacga gcgcggcagc cgcgaggtgg acggcacgac cgtcctgcgc agcacggtcg
    18841 tggtggagtc ccggtccgcc gcggctcggg aagccggcga cctcatccct gagctggaga
    18901 gcggccggct cgaccgggag gcactggtga cgctcgccgg cctggccacc ggagccgcca
    18961 ccgtcgaccc cgaccgcccc cgcctgttca agagcgtcgg catggcctgg gaggacctcg
    19021 cggtcgcggg cgcagcctac gaagccacct gacggcacac acgacggccg ttccgacggc
    19081 cctcgtgcga tgctgggggc gctcggccga ggcgcgtgac ctcggccgat gccaaagatg
    19141 gggagcgtac ggcagcgtga aggcagcaat acgacggacc gttacgggca cctggaaccg
    19201 cttcgcggcc tccgacccgg gactgctgcg actgatggcc gggctgcgga cggtgggggc
    19261 gatcgtgctg accctcgtcg cgctggccct gctcgacacc ggcgtcacgc tcctggtcgc
    19321 gggagccatg gcgtcgatgg tcgctacctt cgccatccgg gagaaggagg tgcgcggcca
    19381 agcagtcacc ctcgcgctcg gcctgccggt ggcgttggcc gcggtggcgc tgggggcgct
    19441 gctgcacagt cggatcatcg ccggtgacct gttcttcatc gcgctgatct tcggcgccgc
    19501 gtacgcccgc cggttcggcg accgcggcac ggcgctgggt ctgatcggct ttcaggtcta
    19561 cttcatctcg ctgttcgtgc acgccaccgt ggccacgctg ccggagctgt tcctgaccct
    19621 ggccgtcgcg ttcgcgtgca gcgcggtggc ccgcttcgcc gccttcccgg acacccccga
    19681 acgcaccctg agccgactgc gggaggcgtt ccgggcccgc ctggcgcagc tggtggcaac
    19741 ccaccgggag ttggtggacg ccgggcccga ggagttggac ggcgtcctcg acgacctgcg
    19801 gcggcacacc gcccggctgc acgagacggc gctgatgatc cagggccgcc tggaggaggg
    19861 cacccgcgac gcaaccaccg cggcgctgct ccagcgccgc atcgcggacg ccgagatcgc
    19921 cgccgaacgc ctggggatga cactgctcaa cgcgcgcagc gcggagcgca ccgacaccct
    19981 taccctgcac ctgccgcacg ccccagtgcc ggccaccgcg aaccgcatgc agtccgaggg
    20041 cgatgccgtg gccacgctcc gccgggacct ggaggccctg gccctgctga tggctcgccg
    20101 ggcgcccgac gaccgcggca ccgcgctggc ccacgtgcgc aaccggctgc tcggctaccg
    20161 cgacgaggac aacctgccgc gcggctcggg cgccgtccag gacgccttcc gcgcgctcgg
    20221 tgaggccgcc cgcgccgtgc tgggtctgcg gctggcactg gacgggccac aggacgagtc
    20281 cgacgacacc tccgccacga tccgctcgcg ggaggagttc gacgccgagg acctggcgat
    20341 cgtcggtgcc gaggaggccg aggaggacga gcacaccggg ctccagcgac ccaccacccg
    20401 ggccgcgttc caggtcgcgg tgggctcggc gttggccatc gtcggcgggg agttcctgtc
    20461 cacccagcgc tggtactggg cggtgctgac ctgctgggtg gttttcctca acaccgcgtc
    20521 caccggcgag gtcctggtca aggggtaccg ccggctggtc ggcacggtgc tgggcgtgat
    20581 cgccggtgtg gcgctggcgg ggctggtggg caaccacacc tggacggcgt tcgcgctggt
    20641 gctgctgtgc gtcttcggca tgttcttcac cgcgccgctg tcgtacgcgc tgatgtcctt
    20701 cttcgtcacc gcgatgctcg gcctgctcta caccgtcctg aacacctaca gcgtcgcgac
    20761 gctggtgctg cgcatcgagg agaccgcgct gggcgcggcg tgcgggatca tcgccgcggc
    20821 ggtcatcctt ccggtgcaca ccgatcggcg caccgacgag catctgggcg ccgtcctgga
    20881 acggctgcgg gaggcggttg cggcggcggt ggcccagctg tccggcgggc cgacggcgga
    20941 cctgctgacc ctggcgcgcg acctggacac cgcgctgaac gacctgcgcg actccactca
    21001 gccgctggtg caccccatca ccccactgcg ggtccgccgg cagaccgcgc
//
