GCF_002865145.1 - 13 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_NBUK01000044.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor	225,091	246,005	Low	polyhydroxyalkanoate	other:other

NZ_NBUK01000052.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	RiPP-like	174,718	185,932

NZ_NBUK01000020.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	thioamitides	134,948	156,961

NZ_NBUK01000055.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	arylpolyene	26,490	67,692

NZ_NBUK01000006.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	T1PKS	51,035	98,537

NZ_NBUK01000078.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 14.1	hserlactone	4,394	25,014

NZ_NBUK01000031.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 23.1	2dos	48,292	82,700

NZ_NBUK01000062.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 34.1	hserlactone	97,221	117,865

NZ_NBUK01000079.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 40.1	thioamitides	1	18,216

NZ_NBUK01000029.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 45.1	hydrogen-cyanide	1	12,684

NZ_NBUK01000063.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 47.1	lanthipeptide-class-ii	1	8,725

NZ_NBUK01000015.1 (Sinorhizobium medicae (Ensifer medicae))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 71.1	terpene	66,346	87,188
Region 71.2	redox-cofactor	253,224	275,411

No secondary metabolite regions were found in these records:: NZ_NBUK01000039.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000069.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000026.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000010.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000002.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000001.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000043.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000025.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000050.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000038.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000033.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000051.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000073.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000016.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000018.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000019.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000047.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000060.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000080.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000017.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000009.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000071.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000046.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000066.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000034.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000054.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000067.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000056.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000011.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000048.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000013.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000068.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000036.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000042.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000027.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000075.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000023.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000028.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000004.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000007.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000030.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000024.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000059.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000061.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000040.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000049.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000077.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000072.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000022.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000032.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000045.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000053.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000064.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000076.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000005.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000021.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000037.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000003.1 (Sinorhizobium medicae (Ensifer medicae)); NZ_NBUK01000057.1 (Sinorhizobium medicae (Ensifer medicae))

Compact view

NZ_NBUK01000044.1 - Region 1 - terpene-precursor

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Location: 225,091 - 246,005 nt. (total: 20,915 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

BMJ25_RS22055: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

BMJ25_RS22095: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase aminotransferase kinase sulfotransferase transketolase

BMJ25_RS22060: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

BMJ25_RS22075: glutathione S-transferase

smcogs: SMCOG1193: glutathione S-transferase

BMJ25_RS22090: aminotransferase

smcogs: SMCOG1019: aminotransferase

BMJ25_RS22115: transketolase

smcogs: SMCOG1204: transketolase

BMJ25_RS22125: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

Ligases: synthase synthetase

BMJ25_RS22085: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

BMJ25_RS22120: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.58	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000867.3	0.50	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001361.3	0.48	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002283.2	0.48	terpene	sodorifen	Serratia plymuthica
BGC0002397.2	0.46	terpene	astallatene	Arabidopsis thaliana
BGC0001184.4	0.45	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000894.4	0.45	other (other)	citrinin	Monascus aurantiacus
BGC0000888.5	0.44	other (other)	bacilysin	Bacillus sp. CS93
BGC0001605.3	0.44	terpene	gibberellin	Sinorhizobium fredii NGR234

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.58	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000867.3	0.50	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001361.3	0.48	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002283.2	0.48	terpene	sodorifen	Serratia plymuthica
BGC0002397.2	0.46	terpene	astallatene	Arabidopsis thaliana
BGC0001184.4	0.45	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000894.4	0.45	other (other)	citrinin	Monascus aurantiacus
BGC0000888.5	0.44	other (other)	bacilysin	Bacillus sp. CS93
BGC0001605.3	0.44	terpene	gibberellin	Sinorhizobium fredii NGR234

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

BMJ25_RS22085: PT_FPPS_like

Domain 1 (42 - 303): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 25.77 out of 29.72

Confidence: strong

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 23.11 out of 27.18

Confidence: medium

Additional weak hits (11):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.24 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.74 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.62 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.74 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.88 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.49 out of 30.25

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.40 out of 26.12

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.76 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.42 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.27 out of 29.38

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.42 out of 35.63

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
NrdR	Represses ribonucleotide reductase encoding genes
NtrC	Nitrogen regulatory protein C

NZ_NBUK01000052.1 - Region 1 - RiPP-like

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Location: 174,718 - 185,932 nt. (total: 11,215 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: hydratase

BMJ25_RS25900: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000483.5	0.34	ribosomal	aeruginosamide B, aeruginosamide C	Microcystis aeruginosa PCC 9432
BGC0000904.5	0.31	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0000471.4	0.31	ribosomal	viridisamide A	Oscillatoria nigro-viridis PCC 7112
BGC0000477.3	0.31	ribosomal	patellin 2, patellin 3	uncultured Prochloron sp. 06037A
BGC0002560.3	0.31	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4
BGC0000480.5	0.31	ribosomal	tenuecyclamide A, tenuecyclamide C	Nostoc spongiaeforme var. tenue str. Carmeli
BGC0000625.5	0.31	ribosomal	thioviridamide	Streptomyces olivoviridis
BGC0000475.5	0.31	ribosomal	patellamide A, patellamide C	Prochloron didemni
BGC0002485.2	0.30	other (other), ribosomal	muscoride A, muscoride B	Desmonostoc sp. PCC 7906
BGC0002551.2	0.30	other (other), ribosomal, terpene	muscoride A, muscoride B	Nostoc sp. UHCC-0398

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000483.5	0.34	ribosomal	aeruginosamide B, aeruginosamide C	Microcystis aeruginosa PCC 9432
BGC0000904.5	0.31	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0000471.4	0.31	ribosomal	viridisamide A	Oscillatoria nigro-viridis PCC 7112
BGC0000477.3	0.31	ribosomal	patellin 2, patellin 3	uncultured Prochloron sp. 06037A
BGC0002560.3	0.31	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4
BGC0000480.5	0.31	ribosomal	tenuecyclamide A, tenuecyclamide C	Nostoc spongiaeforme var. tenue str. Carmeli
BGC0000625.5	0.31	ribosomal	thioviridamide	Streptomyces olivoviridis
BGC0000475.5	0.31	ribosomal	patellamide A, patellamide C	Prochloron didemni
BGC0002485.2	0.30	other (other), ribosomal	muscoride A, muscoride B	Desmonostoc sp. PCC 7906
BGC0002551.2	0.30	other (other), ribosomal, terpene	muscoride A, muscoride B	Nostoc sp. UHCC-0398

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.35 out of 18.57

Confidence: medium

Additional weak hits (8):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.43 out of 30.25

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.12 out of 27.55

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.34 out of 27.78

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.49 out of 39.62

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.82 out of 27.55

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.96 out of 29.65

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.28 out of 28.19

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.78 out of 20.01

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
ToxT	Regulator of MSHA biosynthesis

NZ_NBUK01000020.1 - Region 1 - thioamitides

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Location: 134,948 - 156,961 nt. (total: 22,014 nt) Show pHMM detection rules used

thioamitides: ((YcaO or TIGR03604) and TfuA)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acyltransferase

BMJ25_RS07685: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001849.4	0.45	ribosomal	thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D	Streptomyces varsoviensis
BGC0002560.3	0.45	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4
BGC0000625.5	0.41	ribosomal	thioviridamide	Streptomyces olivoviridis
BGC0001802.5	0.40	ribosomal	thioholgamide A, thioholgamide B	Streptomyces malaysiense
BGC0001696.5	0.40	ribosomal	neothioviridamide	Streptomyces sp.
BGC0002669.2	0.38	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0002120.3	0.31	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0000544.4	0.31	ribosomal	planosporicin	Planomonospora alba
BGC0001510.5	0.28	other (other)	anisomycin	Streptomyces hygrospinosus
BGC0001797.3	0.27	ribosomal	telomestatin	Streptomyces anulatus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001849.4	0.45	ribosomal	thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D	Streptomyces varsoviensis
BGC0002560.3	0.45	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4
BGC0000625.5	0.41	ribosomal	thioviridamide	Streptomyces olivoviridis
BGC0001802.5	0.40	ribosomal	thioholgamide A, thioholgamide B	Streptomyces malaysiense
BGC0001696.5	0.40	ribosomal	neothioviridamide	Streptomyces sp.
BGC0002669.2	0.38	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0002120.3	0.31	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0000544.4	0.31	ribosomal	planosporicin	Planomonospora alba
BGC0001510.5	0.28	other (other)	anisomycin	Streptomyces hygrospinosus
BGC0001797.3	0.27	ribosomal	telomestatin	Streptomyces anulatus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.02 out of 21.84

Confidence: medium

Additional weak hits (7):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.70 out of 20.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.33 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.89 out of 27.78

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.67 out of 35.63

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.97 out of 30.98

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.23 out of 30.98

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.27 out of 18.57

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MexT	Global virulence regulator

NZ_NBUK01000055.1 - Region 1 - arylpolyene

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Location: 26,490 - 67,692 nt. (total: 41,203 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

BMJ25_RS26275: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

BMJ25_RS26280: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

BMJ25_RS26330: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

BMJ25_RS26360: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: aminotransferase

BMJ25_RS26395: aminotransferase

smcogs: SMCOG1019: aminotransferase

Ligases: synthase

BMJ25_RS26365: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

BMJ25_RS26370: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Translocases: transporter

BMJ25_RS26310: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002487.3	0.46	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0002000.4	0.44	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001987.2	0.44	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0002488.3	0.44	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0000196.4	0.44	PKS	AQ-256, AQ-270a, AQ-284a	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002711.2	0.43	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000254.5	0.43	PKS	oxytetracycline	Streptomyces rimosus
BGC0000264.5	0.43	PKS	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0002510.2	0.43	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0002656.2	0.42	PKS	oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B	Streptacidiphilus oryzae TH49

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002487.3	0.46	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0002000.4	0.44	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001987.2	0.44	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0002488.3	0.44	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0000196.4	0.44	PKS	AQ-256, AQ-270a, AQ-284a	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002711.2	0.43	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000254.5	0.43	PKS	oxytetracycline	Streptomyces rimosus
BGC0000264.5	0.43	PKS	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0002510.2	0.43	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0002656.2	0.42	PKS	oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B	Streptacidiphilus oryzae TH49

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.71 out of 20.47

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 23.22 out of 27.55

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 24.74 out of 26.33

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.54 out of 28.19

Confidence: medium

Additional weak hits (9):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.13 out of 26.06

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.42 out of 33.73

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.90 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.55 out of 30.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.59 out of 30.97

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.25 out of 36.53

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.70 out of 32.93

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
GnfM	Regulator of nitrogen-fixation genes
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems
ZuR variant 1	Zinc-responsive repressor

NZ_NBUK01000006.1 - Region 1 - T1PKS

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Location: 51,035 - 98,537 nt. (total: 47,503 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

BMJ25_RS02290: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

BMJ25_RS02315: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

BMJ25_RS02325: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Hydrolases: hydrolase

BMJ25_RS02265: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Ligases: synthase

BMJ25_RS02320: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

Translocases: transporter

BMJ25_RS02270: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.61	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000107.3	0.60	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002154.2	0.60	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.59	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000037.4	0.59	PKS	cichorine	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.61	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000107.3	0.60	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002154.2	0.60	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.59	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000037.4	0.59	PKS	cichorine	Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.87 out of 29.72

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.41 out of 20.97

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 28.19

Confidence: medium

Additional weak hits (6):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.57 out of 20.97

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.10 out of 28.14

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.79 out of 26.85

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.48 out of 28.14

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.25 out of 30.97

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.42 out of 30.25

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 51034 - 98537:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

BMJ25_RS02325: mal

PKS_AT (527..824): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; Propionyl-CoA: 62.5%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 83.8
Methylmalonyl-CoA: 77.5
Methoxymalonyl-CoA: 77.4
Ethylmalonyl-CoA: 44.3
Propionyl-CoA: 33.3
trans-1,2-CPDA: 31.2
3-Methylbutyryl-CoA: 25.0
inactive: 22.1
fatty_acid: 18.6
Isobutyryl-CoA: 18.0
2-Methylbutyryl-CoA: 16.4
CHC-CoA: 13.0
Acetyl-CoA: 7.5
Benzoyl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CcpA	Catabolite control protein A
MexT	Global virulence regulator
NtrC	Nitrogen regulatory protein C
ZuR variant 1	Zinc-responsive repressor

NZ_NBUK01000078.1 - Region 1 - hserlactone

Download region GenBank file

Download region SVG

Location: 4,394 - 25,014 nt. (total: 20,621 nt) Show pHMM detection rules used

Region on contig edge.

hserlactone: Autoind_synth

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001992.3	0.35	other (other)	thioguanine	Erwinia amylovora CFBP1430
BGC0002713.2	0.23	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000453.5	0.22	NRPS	valinomycin	Streptomyces tsusimaensis
BGC0000495.5	0.21	ribosomal	actagardine	Actinoplanes garbadinensis
BGC0000446.5	0.20	NRPS	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca
BGC0000344.5	0.20	NRPS	entolysin	Pseudomonas entomophila L48
BGC0002336.2	0.18	NRPS	bolagladin A, bolagladin B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001992.3	0.35	other (other)	thioguanine	Erwinia amylovora CFBP1430
BGC0002713.2	0.23	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000453.5	0.22	NRPS	valinomycin	Streptomyces tsusimaensis
BGC0000495.5	0.21	ribosomal	actagardine	Actinoplanes garbadinensis
BGC0000446.5	0.20	NRPS	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca
BGC0000344.5	0.20	NRPS	entolysin	Pseudomonas entomophila L48
BGC0002336.2	0.18	NRPS	bolagladin A, bolagladin B	Burkholderia gladioli

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.13 out of 20.97

Confidence: medium

Additional weak hits (5):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.62 out of 30.22

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.68 out of 27.18

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.31 out of 29.65

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.02 out of 32.93

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.37 out of 29.25

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
RpoN	Regulator of nitrogen assimilation and virulence

NZ_NBUK01000031.1 - Region 1 - 2dos

Download region GenBank file

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Location: 48,292 - 82,700 nt. (total: 34,409 nt) Show pHMM detection rules used

2dos: ((DOIS or DHQ_synthase or ValA or salQ) and DegT_DnrJ_EryC1 and (LipV or ADSI-DH or cds(ADH_N and ADH_zinc_N)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acyltransferase aminotransferase transferase

BMJ25_RS15120: acyltransferase

smcogs: SMCOG1141: acyltransferase

BMJ25_RS15140: aminotransferase

smcogs: SMCOG1019: aminotransferase

BMJ25_RS15235: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: hydrolase

BMJ25_RS15150: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

BMJ25_RS15260: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

Ligases: synthase

BMJ25_RS15210: 3-dehydroquinate synthase

smcogs: SMCOG1183: 3-dehydroquinate synthase

BMJ25_RS15250: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002584.2	0.43	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001206.5	0.43	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0001485.4	0.42	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002116.3	0.42	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0001534.3	0.41	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001267.3	0.41	terpene	elymoclavine, Agroclavine I	Claviceps fusiformis
BGC0001229.4	0.41	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000925.5	0.41	other (other)	quinolobactin	Pseudomonas fluorescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002584.2	0.43	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001206.5	0.43	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0001485.4	0.42	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002116.3	0.42	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0001534.3	0.41	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001267.3	0.41	terpene	elymoclavine, Agroclavine I	Claviceps fusiformis
BGC0001229.4	0.41	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000925.5	0.41	other (other)	quinolobactin	Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.41 out of 27.55

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.74 out of 20.47

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.59 out of 18.57

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.29 out of 25.31

Confidence: medium

Additional weak hits (6):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.46 out of 21.55

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.79 out of 20.01

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.48 out of 32.74

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.09 out of 20.01

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.66 out of 29.25

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.90 out of 24.78

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
GnfM	Regulator of nitrogen-fixation genes
MexT	Global virulence regulator
ToxT	Regulator of MSHA biosynthesis
VqsM	Regulator of quorum-sensing signalling systems

NZ_NBUK01000062.1 - Region 1 - hserlactone

Download region GenBank file

Download region SVG

Location: 97,221 - 117,865 nt. (total: 20,645 nt) Show pHMM detection rules used

hserlactone: Autoind_synth

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

BMJ25_RS28925: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: hydratase

BMJ25_RS28910: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Isomerases: racemase

BMJ25_RS28965: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001555.4	0.41	ribosomal	colicin V	Escherichia coli chi7122
BGC0000584.5	0.40	ribosomal	colicin V	Escherichia coli
BGC0001660.3	0.40	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000589.5	0.39	ribosomal	microcin M	Escherichia coli Nissle 1917
BGC0000588.5	0.39	ribosomal	microcin L	Escherichia coli
BGC0000561.5	0.39	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0000587.5	0.39	ribosomal	microcin H47	Escherichia coli
BGC0000498.5	0.38	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0001684.3	0.38	other (other)	N-acyloxyacyl glutamine	Klebsiella variicola
BGC0000188.5	0.38	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001555.4	0.41	ribosomal	colicin V	Escherichia coli chi7122
BGC0000584.5	0.40	ribosomal	colicin V	Escherichia coli
BGC0001660.3	0.40	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000589.5	0.39	ribosomal	microcin M	Escherichia coli Nissle 1917
BGC0000588.5	0.39	ribosomal	microcin L	Escherichia coli
BGC0000561.5	0.39	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0000587.5	0.39	ribosomal	microcin H47	Escherichia coli
BGC0000498.5	0.38	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0001684.3	0.38	other (other)	N-acyloxyacyl glutamine	Klebsiella variicola
BGC0000188.5	0.38	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 21.40 out of 23.05

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

Additional weak hits (11):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.00 out of 27.78

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.27 out of 30.97

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.75 out of 26.12

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.52 out of 18.57

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.27 out of 32.74

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.42 out of 33.73

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.58 out of 30.22

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.46 out of 32.74

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.55 out of 27.78

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.76 out of 32.93

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.81 out of 32.93

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsR	Pleiotropic regulatory for antibiotic production

NZ_NBUK01000079.1 - Region 1 - thioamitides

Download region GenBank file

Download region SVG

Location: 1 - 18,216 nt. (total: 18,216 nt) Show pHMM detection rules used

Region on contig edge.

thioamitides: ((YcaO or TIGR03604) and TfuA)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

BMJ25_RS32570: methyltransferase

smcogs: SMCOG1089: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.49	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0002560.3	0.49	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4
BGC0001802.5	0.45	ribosomal	thioholgamide A, thioholgamide B	Streptomyces malaysiense
BGC0001696.5	0.45	ribosomal	neothioviridamide	Streptomyces sp.
BGC0000772.5	0.42	saccharide	lipopolysaccharide	Brucella melitensis
BGC0000625.5	0.41	ribosomal	thioviridamide	Streptomyces olivoviridis
BGC0002669.2	0.40	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0002120.3	0.39	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0001474.4	0.38	ribosomal	thiopeptin	Streptomyces tateyamensis
BGC0001687.3	0.36	other (other)	N-tetradecanoyl tyrosine	uncultured bacterium CSL12

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.49	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0002560.3	0.49	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4
BGC0001802.5	0.45	ribosomal	thioholgamide A, thioholgamide B	Streptomyces malaysiense
BGC0001696.5	0.45	ribosomal	neothioviridamide	Streptomyces sp.
BGC0000772.5	0.42	saccharide	lipopolysaccharide	Brucella melitensis
BGC0000625.5	0.41	ribosomal	thioviridamide	Streptomyces olivoviridis
BGC0002669.2	0.40	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0002120.3	0.39	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0001474.4	0.38	ribosomal	thiopeptin	Streptomyces tateyamensis
BGC0001687.3	0.36	other (other)	N-tetradecanoyl tyrosine	uncultured bacterium CSL12

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.64 out of 25.31

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.89 out of 23.79

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.77 out of 28.19

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.64 out of 25.31

Confidence: medium

Additional weak hits (3):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.64 out of 29.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.80 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.97 out of 24.78

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CatR	H2O2-responsive repressor
IolR	Regulator of the inositol catabolism
ZuR variant 1	Zinc-responsive repressor

NZ_NBUK01000029.1 - Region 1 - hydrogen-cyanide

Download region GenBank file

Download region SVG

Location: 1 - 12,684 nt. (total: 12,684 nt) Show pHMM detection rules used

Region on contig edge.

hydrogen-cyanide: (Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

BMJ25_RS12655: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

BMJ25_RS12665: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Isomerases: racemase

BMJ25_RS12675: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002116.3	0.41	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000575.5	0.40	ribosomal	lariatin	Rhodococcus jostii
BGC0002425.3	0.40	ribosomal	stlassin	Streptomyces sp.
BGC0001391.3	0.39	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0002110.3	0.39	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000410.5	0.39	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0001870.3	0.39	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000549.3	0.37	ribosomal	salivaricin D	Streptococcus salivarius
BGC0002285.2	0.37	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000433.5	0.36	NRPS	surfactin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002116.3	0.41	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000575.5	0.40	ribosomal	lariatin	Rhodococcus jostii
BGC0002425.3	0.40	ribosomal	stlassin	Streptomyces sp.
BGC0001391.3	0.39	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0002110.3	0.39	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000410.5	0.39	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0001870.3	0.39	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000549.3	0.37	ribosomal	salivaricin D	Streptococcus salivarius
BGC0002285.2	0.37	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000433.5	0.36	NRPS	surfactin	Bacillus velezensis FZB42

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

NZ_NBUK01000063.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1 - 8,725 nt. (total: 8,725 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

BMJ25_RS30185: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.42	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002699.2	0.36	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0002110.3	0.32	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001867.2	0.28	ribosomal	prochlorosins	Prochlorococcus marinus str. MIT 9313
BGC0002560.3	0.25	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.42	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002699.2	0.36	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0002110.3	0.32	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001867.2	0.28	ribosomal	prochlorosins	Prochlorococcus marinus str. MIT 9313
BGC0002560.3	0.25	ribosomal	thiostreptamide S4	Streptomyces sp. NRRL S-4

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for BMJ25_RS30185

allorf_6661_6894

Leader:

MMVVYLRASPSAAYQRINSCQPIRDNESAIS

Core:

YLSEVAERLNKQLIKVQGENMVTKSLIKRLMMLVCPPSRRVPPGLG

Core with dehydrations:

YLDhaEVAERLNKQLIKVQGENMVDhbKDhaLIKRLMMLVCysPPDhaRRVPPGLG

antiSMASH-DB 4.0 matches for allorf_6661_6894

100.0%

NC_009621.1and 4 others:

NZ_CP088111.1 Lanthipeptides: allorf_0786726_0786959_lanthipeptideNZ_NBUK01000063.1 Lanthipeptides: allorf_6661_6894_lanthipeptideNZ_VISX01000063.1 Lanthipeptides: allorf_1862_2095_lanthipeptideNZ_VITA01000039.1 Lanthipeptides: allorf_06616_06849_lanthipeptide

Lanthipeptides: allorf_1020482_1020715_lanthipeptide

1

YLSEVAERLNKQLIKVQGENMVTKSLIKRLMMLVCPPSRRVPPGLG

46

YLSEVAERLNKQLIKVQGENMVTKSLIKRLMMLVCPPSRRVPPGLG

1

YLSEVAERLNKQLIKVQGENMVTKSLIKRLMMLVCPPSRRVPPGLG

46

19.6%

NZ_FMHJ01000003.1:

Lanthipeptides: allorf_516193_516348_lanthipeptide

23

TKSLIKRLMMLVCP--PSRRVPPG

44

++ KRL +C P RR P G

5

SRGRGKRLRNALCGGWPGRRAPQG

28

17.4%

NZ_BLIS01000009.1and 5 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04860_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptide

Lanthipeptides: GVO03_RS04860_lanthipeptide

17

QGENMVTKSLIKRLMMLVC

35

+GEN+ T L+K + L C

10

KGENVTTDILLKICIALDC

28

with 1 more sequence matches

12.5%

NZ_CP086102.1and 1 other:

NZ_KZ195572.1 Lanthipeptides: allorf_6138327_6138542_lanthipeptide

Lanthipeptides: allorf_6127439_6127654_lanthipeptide

27

IKRLMMLVCPPSR

39

+RL M +CP R

21

ARRLFMCLCPHCR

33

allorf_7325_7396

Leader:

MVASAGG

Core:

FPAPARSAEPADVHNC

Core with dehydrations:

FPAPARDhaAEPADVHNCys

antiSMASH-DB 4.0 matches for allorf_7325_7396

100.0%

NC_009621.1and 6 others:

NC_017327.1 Lanthipeptides: allorf_0124171_0124311_lanthipeptideNZ_CP021217.1 Lanthipeptides: allorf_1159796_1159936_lanthipeptideNZ_CP088111.1 Lanthipeptides: allorf_0786224_0786295_lanthipeptideNZ_NBUK01000063.1 Lanthipeptides: allorf_7325_7396_lanthipeptideNZ_VISX01000063.1 Lanthipeptides: allorf_1360_1431_lanthipeptideNZ_VITA01000039.1 Lanthipeptides: allorf_07280_07351_lanthipeptide

Lanthipeptides: allorf_1019980_1020051_lanthipeptide

1

FPAPARSAEPADVHNC

16

FPAPARSAEPADVHNC

1

FPAPARSAEPADVHNC

16

43.8%

NZ_CP077072.1:

Lanthipeptides: allorf_2549811_2549951_lanthipeptide

3

APARSAEPAD

12

AP R AEP D

6

APPRHAEPHD

15

allorf_7639_7821

Leader:

MLNCAQRAFSKAPLPTGVIWRCSVIPTLRVVGTIPGA

Core:

PSAAATASIPVDTWPFSTKDSDC

Core with dehydrations:

PDhaAAADhbADhaIPVDDhbWPFDhaDhbKDDhaDCys

antiSMASH-DB 4.0 matches for allorf_7639_7821

100.0%

NC_009621.1and 3 others:

NZ_CP088111.1 Lanthipeptides: allorf_0785799_0785981_lanthipeptideNZ_NBUK01000063.1 Lanthipeptides: allorf_7639_7821_lanthipeptideNZ_VISX01000063.1 Lanthipeptides: allorf_0935_1117_lanthipeptide

Lanthipeptides: allorf_1019555_1019737_lanthipeptide

1

PSAAATASIPVDTWPFSTKDSDC

23

PSAAATASIPVDTWPFSTKDSDC

1

PSAAATASIPVDTWPFSTKDSDC

23

22.6%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: allorf_335035_335211_lanthipeptide

Lanthipeptides: allorf_335035_335211_lanthipeptide

2

SAAATASIPVDTWPF

16

+AAA S+P T P+

10

TAAAHRSVPTRTCPY

24

17.9%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29340_lanthipeptide

Lanthipeptides: CN427_RS29340_lanthipeptide

5

ATASIPVDTWPFSTKDSDC

23

A ++ V TW F T + C

12

AGLTVAVGTWVFQTSEKTC

30

with 1 more sequence matches

17.9%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS31525_lanthipeptide

Lanthipeptides: CN427_RS31525_lanthipeptide

8

SIPVDTWPFSTKDSDC

23

++ V TW F T D C

15

TVAVGTWVFQTSDKTC

30

allorf_7824_7970

Leader:

MQPTSLGG

Core:

PRPLHFILVDCAPVANPTYVEADLRATMKHDQFMCFAIHV

Core with dehydrations:

PRPLHFILVDCysAPVANPDhbYVEADLRADhbMKHDQFMCysFAIHV

antiSMASH-DB 4.0 matches for allorf_7824_7970

100.0%

NC_009621.1and 4 others:

NZ_CP088111.1 Lanthipeptides: allorf_0785650_0785796_lanthipeptideNZ_NBUK01000063.1 Lanthipeptides: allorf_7824_7970_lanthipeptideNZ_VISX01000063.1 Lanthipeptides: allorf_0786_0932_lanthipeptideNZ_VITA01000039.1 Lanthipeptides: allorf_07780_07926_lanthipeptide

Lanthipeptides: allorf_1019406_1019552_lanthipeptide

1

PRPLHFILVDCAPVANPTYVEADLRATMKHDQFMCFAIHV

40

PRPLHFILVDCAPVANPTYVEADLRATMKHDQFMCFAIHV

1

PRPLHFILVDCAPVANPTYVEADLRATMKHDQFMCFAIHV

40

97.5%

NC_017327.1and 1 other:

NZ_CP021217.1 Lanthipeptides: allorf_1159245_1159391_lanthipeptide

Lanthipeptides: allorf_0124716_0124862_lanthipeptide

1

PRPLHFILVDCAPVANPTYVEADLRATMKHDQFMCFAIHV

40

PRPLHFILVDCAPVANPTYV+ADLRATMKHDQFMCFAIHV

1

PRPLHFILVDCAPVANPTYVDADLRATMKHDQFMCFAIHV

40

20.0%

NZ_CP015591.1and 15 others:

NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide

Lanthipeptides: A7A70_RS27550_lanthipeptide

15

ANPTYVEADLRATMK

29

A PT VEA + AT+

10

ATPTIVEATIAATVS

24

with 4 more sequence matches

20.0%

NZ_CP059734.1:

Lanthipeptides: allorf_0384683_0384871_lanthipeptide

4

LHFILVDCAPVANP

17

LH + C PVANP

1

LHIYFLTCQPVANP

14

17.5%

NZ_CP012109.1:

Lanthipeptides: allorf_7979331_7979543_lanthipeptide

1

PRPLHFILVDCAP

13

PRP +L DC P

14

PRPARALLRDCRP

26

17.5%

NZ_FONG01000023.1:

Lanthipeptides: allorf_088862_088996_lanthipeptide

10

DCAPVANPTYVEADLRA

26

D AP PT +LR

7

DAAPPTQPTRRRPELRG

23

12.5%

NZ_VIKW01000003.1:

Lanthipeptides: FJR04_RS03310_lanthipeptide

3

PLHFILVDCAPVA

15

P H + V C P+

7

PFHTLWVGCKPIG

19

allorf_7954_8058

Leader:

MRYMYEATYARLCPSSSTISKIYLKQITGS

Core:

NCTI

Core with dehydrations:

NCysDhbI

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.34 out of 39.62

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.62 out of 30.97

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 25.58 out of 30.98

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

allorf_6661_6894 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 5118.9 Da

Molecular weight: 5122.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5140.2 Da N = 1; 5158.2 Da N = 2; 5176.2 Da N = 3

allorf_7325_7396 - Class II

Cleavage pHMM score: -5.40

RODEO score: 0

Monoisotopic mass: 1662.8 Da

Molecular weight: 1663.8 Da

Number of bridges: 1

allorf_7639_7821 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 2240.1 Da

Molecular weight: 2241.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2259.4 Da N = 1; 2277.4 Da N = 2; 2295.5 Da N = 3; 2313.5 Da N = 4; 2331.5 Da N = 5; 2349.5 Da N = 6

allorf_7824_7970 - Class II

Cleavage pHMM score: -5.30

RODEO score: 0

Monoisotopic mass: 4529.3 Da

Molecular weight: 4532.3 Da

Number of bridges: 2

allorf_7954_8058 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 431.2 Da

Molecular weight: 431.5 Da

Number of bridges: 1

TFBS definitions

Regulator	Description

NZ_NBUK01000015.1 - Region 1 - terpene

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Location: 66,346 - 87,188 nt. (total: 20,843 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	terpene	Similarity score	Type	Compound(s)	Organism
BGC0002120.3		0.25	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0000698.5		0.18	saccharide	hygromycin A	Streptomyces hygroscopicus

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0002120.3		0.25	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0000698.5		0.18	saccharide	hygromycin A	Streptomyces hygroscopicus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
triterpene		squalene	C30	acyclic	none
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

BMJ25_RS04015: PT_phytoene_like

Domain 1 (12 - 277): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → PSPP; FPP → squalene; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.74 out of 25.88

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.52 out of 27.55

Confidence: medium

Additional weak hits (1):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.70 out of 31.73

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes
PsrA	Oleic acid responsive regulator

NZ_NBUK01000015.1 - Region 2 - redox-cofactor

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Location: 253,224 - 275,411 nt. (total: 22,188 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

BMJ25_RS04965: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: transketolase

BMJ25_RS04915: transketolase

smcogs: SMCOG1204: transketolase

Hydrolases: hydrolase

BMJ25_RS04980: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002571.2	0.43	NRPS	pyoverdine DC3000	Pseudomonas syringae pv. tomato str. DC3000
BGC0002404.2	0.41	other (other)	falcarindiol	Solanum lycopersicum
BGC0002575.2	0.41	ribosomal	cochonodin I	Streptococcus suis
BGC0000043.5	0.39	PKS	curacin A	Moorea producens 19L
BGC0002514.3	0.38	PKS	julichrome Q6.6	Streptomyces sampsonii
BGC0002012.4	0.37	PKS	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0002181.3	0.37	terpene	pleuromutilin	Rhodocybe pseudopiperita
BGC0000252.5	0.37	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0001605.3	0.37	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002000.4	0.37	PKS	setomimycin	Streptomyces aurantiacus JA 4570

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002571.2	0.43	NRPS	pyoverdine DC3000	Pseudomonas syringae pv. tomato str. DC3000
BGC0002404.2	0.41	other (other)	falcarindiol	Solanum lycopersicum
BGC0002575.2	0.41	ribosomal	cochonodin I	Streptococcus suis
BGC0000043.5	0.39	PKS	curacin A	Moorea producens 19L
BGC0002514.3	0.38	PKS	julichrome Q6.6	Streptomyces sampsonii
BGC0002012.4	0.37	PKS	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0002181.3	0.37	terpene	pleuromutilin	Rhodocybe pseudopiperita
BGC0000252.5	0.37	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0001605.3	0.37	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002000.4	0.37	PKS	setomimycin	Streptomyces aurantiacus JA 4570

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.19 out of 20.47

Confidence: strong

Additional weak hits (8):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.38 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.98 out of 29.38

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.95 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.39 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.28 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.13 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.32 out of 33.14

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.53 out of 23.43

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: PqqD_RRE; Location: 7 - 95; Score: 93.9; RRE type: Thurincin_rSAM_RRE; Location: 34 - 89; Score: 27.1

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems