LOCUS       NZ_CP017780            22544 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Amycolatopsis sp. BJA-103 chromosome, complete genome.
ACCESSION   NZ_CP017780
VERSION     NZ_CP017780.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. BJA-103
  ORGANISM  Amycolatopsis sp. BJA-103
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9488490)
  AUTHORS   Ke,X. and Jia,L.
  TITLE     Isolation and identification of a potent feather degrading rare
            actinomycete Amycolatosis sp. BJA-103 isolated from the rhizomes of
            Valeriana jatamansi Jones with abundant antibiotic biosynthetic
            potential
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9488490)
  AUTHORS   Ke,X. and Jia,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-OCT-2016) College of Life Sciences, Northwest A&F
            Unversity, No.22 Xinong Road, YangLing, Shaanxi 712100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: AUG-2016
            Assembly Method                   :: SMRT v. 2.3.0
            Assembly Name :: version 2.3.0 of the PacBio Single Molecule Real
            Time
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:58:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,631
            CDSs (total)                      :: 8,562
            Genes (coding)                    :: 8,496
            CDSs (with protein)               :: 8,496
            Genes (RNA)                       :: 69
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 31 of 66
            Pseudo Genes (incomplete)         :: 47 of 66
            Pseudo Genes (internal stop)      :: 2 of 66
            Pseudo Genes (multiple problems)  :: 13 of 66
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:43:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8110596
            Orig. end                         :: 8133140
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017780.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from B415, College of Life
            Sciences, Northwest A&F Unversity.
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22544
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="33"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22544
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22544
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12544](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12544
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(224..964)
                     /locus_tag="BKN51_RS36430"
                     /old_locus_tag="BKN51_35945"
     CDS             complement(224..964)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102284.1"
                     /locus_tag="BKN51_RS36430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_35945"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_101611909.1"
                     /transl_table=11
                     /translation="MLTIGQLAATAGVTVRAVRHYHHVGLLPEPGRDASGYRRYSAEAA
                     VDLIRIRTLADAGVPLARIDALLHARPAEFAAAIADIDAELRRKIDQLTENRLRIAELA
                     VGERLVLPPGVVALLDRMRDLGVSEQRVLLERDAWILMRALDPHVVPERLREKNAAFDD
                     PETLRVHLACDQAIGWDPRDPRLDRLIDDLDAWEVGHEGDGGRPGYLELVVSRISEASP
                     AWQRVVGELTHRARLRAERESAGE"
     gene            complement(999..1892)
                     /locus_tag="BKN51_RS36435"
                     /old_locus_tag="BKN51_35950"
     CDS             complement(999..1892)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (35-146). E-value:
                     1.4e-11. Score: 36.4. Matches aSDomain:
                     nrpspksdomains_BKN51_RS36435_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102285.1"
                     /locus_tag="BKN51_RS36435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_35950"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_101611910.1"
                     /sec_met_domain="PF00561 (E-value: 2.2e-09, bitscore: 36.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.2e-09, bitscore:
                     38.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNDSTSPARFAPPIGGFEELDGRRLFLHRSGDGGPAVVFLPGAS
                     AVGLDYLGVQQEVARFTTAVVYDRGGTGYSDPLPLPRTAVEVATELRELLFALDIPGPY
                     VLAAHSLGGLYAHGFAQLHPREVAGLVWLDALHPAWDDFMPPSASLAEAERTAPDLDRL
                     GELRPVLRETYAELRTGYPDHVREALVEAKVSDGWLRAGVAERTGLVELAAELRAGPDL
                     PDVPVIALTVVGNDPAQPEQLSRELHDGKTKMDAALVSRVSYGEQRVLTDTLHHRLCFD
                     RPDAVTQAIRDVIDRS"
     aSDomain        complement(1455..1787)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BKN51_RS36435_Abhydrolase_1.1"
                     /evalue="1.40E-11"
                     /label="BKN51_RS36435_Abhydrolase_1.1"
                     /locus_tag="BKN51_RS36435"
                     /protein_end="146"
                     /protein_start="35"
                     /score="36.4"
                     /tool="antismash"
                     /translation="PAVVFLPGASAVGLDYLGVQQEVARFTTAVVYDRGGTGYSDPLPL
                     PRTAVEVATELRELLFALDIPGPYVLAAHSLGGLYAHGFAQLHPREVAGLVWLDALHPA
                     WDDFMPP"
     CDS_motif       complement(1530..1589)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BKN51_RS36435_0001"
                     /evalue="3.50E-04"
                     /label="NRPS-te1"
                     /locus_tag="BKN51_RS36435"
                     /protein_end="121"
                     /protein_start="101"
                     /score="13.2"
                     /tool="antismash"
                     /translation="GPYVLAAHSLGGLYAHGFAQ"
     gene            2090..2293
                     /locus_tag="BKN51_RS36440"
                     /old_locus_tag="BKN51_35955"
     CDS             2090..2293
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005441988.1"
                     /locus_tag="BKN51_RS36440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_35955"
                     /product="cold-shock protein"
                     /protein_id="WP_037319102.1"
                     /transl_table=11
                     /translation="MAQGSVKWFNGEKGFGFIAQDDGGPDVFVHYSEIQGNGFKSLDEG
                     QRVEFEIGQGQKGPQAQRVVAI"
     misc_feature    2294..2303
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.42"
                     /tool="antismash"
     gene            2465..3109
                     /locus_tag="BKN51_RS36445"
                     /old_locus_tag="BKN51_35960"
     CDS             2465..3109
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030754.1"
                     /locus_tag="BKN51_RS36445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_35960"
                     /product="GNAT family protein"
                     /protein_id="WP_101611911.1"
                     /transl_table=11
                     /translation="MRPDTVSRSATEPEQVGRKVRLREVGLRDRRVLMGFDRDMAREAT
                     PLIGGGHRHWASHRSGSAGDDIHFGIETVRGRMLVGSVCTIGADPVTGLFGYGIGIAPR
                     HQRCGYATDAITVLLAHMFEQRGFRKCEVSVYGGNLASLSLHGGLGFREEGRLRDTEVV
                     RGEIKYLVRMGITAEEFAARPSDGPDDLGRRGQHRRPRRGKHWRAPATVSG"
     gene            complement(3099..3746)
                     /locus_tag="BKN51_RS36450"
                     /old_locus_tag="BKN51_35965"
     CDS             complement(3099..3746)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163340.1"
                     /locus_tag="BKN51_RS36450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_35965"
                     /product="response regulator transcription factor"
                     /protein_id="WP_101611912.1"
                     /transl_table=11
                     /translation="MTIRVVIADDQTLVRTGLRMILDNAGDIDVVGEAGDGAEAVRMVA
                     DLDPDVVLMDIRMPEMDGVEATTAIAAAHRARVLVLTTFDLDEYVYAALQAGASGFLLK
                     DALAPDLISGVRVVAAGEATLAPTVTRRLLDRVVTGLPAPSPDARLALLTGREHEVLEQ
                     LARGLSNAEIAGLLYLSQGTVKTHVGRILTKLGLRDRVQAVVFAYESGMISR"
     gene            complement(3743..4948)
                     /locus_tag="BKN51_RS36455"
                     /old_locus_tag="BKN51_35970"
     CDS             complement(3743..4948)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633037.1"
                     /locus_tag="BKN51_RS36455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_35970"
                     /product="sensor histidine kinase"
                     /protein_id="WP_101611913.1"
                     /transl_table=11
                     /translation="MPAILRSHPKSVDLGLTVLIGLSTVVTTDDPEGFEWWLASLVSLA
                     SLLIRHRSPAITFAAGAVVSLLHLAMGNDLRPVDFVALIGLFSVAAWGSRRLSLALLAA
                     GLLVAGAWSFHAAETNSRTSDPEPPRIIVIDRLAPPTDLDGDHRQVQDWGGFAGIGLSL
                     AVAWLAGLNTRQRRIRLSVLEQRAADLERERDTQAALAVAAERGRISRELHDVVAHALS
                     VVVLQAQGAQAELERRPERAREALDAIVGTGRTALSEIRRLLGALGQDAPDWEPQPGAE
                     RLPRLAADIRAAGTPVEFVVEGEPRPLPSTVDLAAYRIVQEALTNVLKHAGPDASVTIV
                     MRYGPGALDIEVTDDGVAAEPPSGTGHGLEGMRERVNVLGGTFDAGPRPDHGFAVRASL
                     PS"
     misc_feature    5086..5101
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.05"
                     /tool="antismash"
     gene            5087..6187
                     /locus_tag="BKN51_RS36460"
                     /old_locus_tag="BKN51_35975"
     CDS             5087..6187
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330821.1"
                     /locus_tag="BKN51_RS36460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_35975"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_101611914.1"
                     /transl_table=11
                     /translation="MRRLLVALVALAAVVPMASPASAAAAPLTLPPPTGPQPVGSTDLH
                     LVDSARQDPWVPTGPRELMVSMFYPALLPLGPKRPYLTLAEAKAFLTESGVPDVDPARL
                     SGIRASARVDAPPLPGKRALVVLSPGFGKPRTTLTGLAEELASKGFVVALIGHNYESHG
                     TAFPDGRVTECAACGSESTLIPPIRAADVSFVLDTLTRPTSPWSRLIDRARIGMAGHSI
                     GGYSTPTAMVADRRIRAGVDMDGRLWSPVPASGIDRPFLLLGRESEYTPAGPDTTWAGS
                     WPNLTGWKRWISVATAGHASFTDVGPLGEQLGLAPPGTLGGARGLALTRAYVSAFFDKN
                     LRGGRQPLLDGPVAGNPEIKFWNRPR"
     gene            complement(6162..7121)
                     /locus_tag="BKN51_RS36465"
                     /old_locus_tag="BKN51_35980"
     CDS             complement(6162..7121)
                     /NRPS_PKS="Domain: PKS_KR (32-141). E-value: 1.3e-06.
                     Score: 20.4. Matches aSDomain:
                     nrpspksdomains_BKN51_RS36465_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163345.1"
                     /locus_tag="BKN51_RS36465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_35980"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_101611915.1"
                     /transl_table=11
                     /translation="MTTSQHKIGSGFGARSTAEEVLRGIDLSGELAIVTGGYSGLGLET
                     TRALANAGAHVVVPARRPADAEAALAGISGTEVGELDLADLTSVETFARRFLGTGRSVD
                     ILIANAGIMAAPERRVGPGWEAHFAINHLGHFALVNRLWPALTADGGARVVMVSSAGHH
                     SSPMRWDDVQFEGGYDRWLAYGQAKTANVLFAVQLDAIGAEHGIRAFSLHPGAILTPLQ
                     RHLRQEEMVEFGWIDENGDQADPDFKSPEQGAATQVWAATSPRLADMGGLYCEDCDVAE
                     IVAEEGEWVGVRPFAIDTGEAARLWQVSAGLTGVGSRT"
     CDS_motif       complement(6561..6674)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BKN51_RS36465_0002"
                     /evalue="2.70E+01"
                     /label="PKSI-KR_m1"
                     /locus_tag="BKN51_RS36465"
                     /protein_end="187"
                     /protein_start="149"
                     /score="-2.4"
                     /tool="antismash"
                     /translation="GGARVVMVSSAGHHSSPMRWDDVQFEGGYDRWLAYGQA"
     aSDomain        complement(6699..7025)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BKN51_RS36465_PKS_KR.1"
                     /evalue="1.30E-06"
                     /label="BKN51_RS36465_PKS_KR.1"
                     /locus_tag="BKN51_RS36465"
                     /protein_end="141"
                     /protein_start="32"
                     /score="20.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="IVTGGYSGLGLETTRALANAGAHVVVPARRPADAEAALAGISGTE
                     VGELDLADLTSVETFARRFLGTGRSVDILIANAGIMAAPERRVGPGWEAHFAINHLGHF
                     ALVNR"
     CDS_motif       complement(6948..7025)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BKN51_RS36465_0001"
                     /evalue="1.00E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="BKN51_RS36465"
                     /protein_end="58"
                     /protein_start="32"
                     /score="21.4"
                     /tool="antismash"
                     /translation="IVTGGYSGLGLETTRALANAGAHVVV"
     gene            7177..7569
                     /locus_tag="BKN51_RS36470"
                     /old_locus_tag="BKN51_35985"
     CDS             7177..7569
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009947867.1"
                     /locus_tag="BKN51_RS36470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_35985"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_101611916.1"
                     /transl_table=11
                     /translation="MTELAIGKVTDRTGLSVHALRFYEKEGLLAGPVKRDANGHRVYTE
                     HDVEWILNCTKFRASGMPLATIREFAELVRQGPGNEEKRLDLLREHQNTVRARIAELAD
                     CLELISRKVEVYEEHVARGTAGDLWH"
     gene            7678..8664
                     /locus_tag="BKN51_RS36475"
                     /old_locus_tag="BKN51_35990"
     CDS             7678..8664
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633041.1"
                     /locus_tag="BKN51_RS36475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_35990"
                     /product="MCE family protein"
                     /protein_id="WP_101611917.1"
                     /transl_table=11
                     /translation="MRSFGAVDPVKMALAGLTTMTLGMAAALNADALPVIGGGTTYSAE
                     FSDAGGLHEDNDVRVAGVKVGKVSEIDLEGDRVHVSFRVKDAWLGDATSASIQIKNVLG
                     QKYLALDPRGEAVLDPGDPIPLRRTTAPYDVLEAFRDLSKTVDAIDVDQLAKSFDAISA
                     TFADTPADVRAALDGISKLSGTIASRDRQLRTLVANTRQVSQTLVDRDTEAQRLIQDGN
                     TLLRAISTRQQAIKDLLDGSKRLATALDGIIADNDGQLGPVLEQLDRLTSMLQRNQDSL
                     AKGIAAFAPAIRVLTNVAGNGHWIDGYLCGLVLPSFGPINEKGCFEK"
     gene            complement(8782..9216)
                     /locus_tag="BKN51_RS36480"
                     /old_locus_tag="BKN51_35995"
     CDS             complement(8782..9216)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163353.1"
                     /locus_tag="BKN51_RS36480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_35995"
                     /product="hypothetical protein"
                     /protein_id="WP_174720499.1"
                     /transl_table=11
                     /translation="MPEETEENTVDTATDTRTDKASGPGRILVAVYAIFALAATSRAAV
                     QISTKFGEAPLAYALSAFAAVVYLLATVALARRGAGWWRIALVACGIELLGVLTVGTFS
                     LFDREAFPHATVWSVYGQGYLFIPLVLPVVGLFWLRRTKP"
     gene            complement(9209..9574)
                     /locus_tag="BKN51_RS36485"
                     /old_locus_tag="BKN51_36000"
     CDS             complement(9209..9574)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633043.1"
                     /locus_tag="BKN51_RS36485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_36000"
                     /product="hypothetical protein"
                     /protein_id="WP_101611918.1"
                     /transl_table=11
                     /translation="MITGFAVTVAICATLVAVWSFVQSARRKLPDNPLLAGLAVVELLL
                     VAQLVIGVVLLIDGGRPGSMATYLAYLIGSLVVLPLGTFWALAERTRSSTAILGIACLA
                     IPVMVLRLHEVWAGASA"
     misc_feature    complement(9676..9691)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.41"
                     /tool="antismash"
     misc_feature    9780..9793
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.41"
                     /tool="antismash"
     gene            10001..12544
                     /gene="lanKC"
                     /locus_tag="BKN51_RS36490"
                     /old_locus_tag="BKN51_36005"
     CDS             10001..12544
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633044.1"
                     /locus_tag="BKN51_RS36490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_36005"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_101611919.1"
                     /sec_met_domain="micKC (E-value: 0.0, bitscore: 1331.5,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 9.2e-13, bitscore: 47.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 6.7e-08, bitscore: 31.7,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6.6e-10, bitscore:
                     37.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVRYEAYCFADPLFFDEQRETGDAADDFASLLPAPESGWRTGVR
                     GVWRMMHPLARNLPLQGWKIHVSAGLGNAERVLVKVHEHCLEHNLSYKHLRSRSTLLAR
                     NSKYAPRDGSGKLLTLYPADNNELERVLVELSAKLDGEPGAYILSDLRYGAGPLYVRYG
                     GFAEQWVELDGKRVLAVRKPDGTLVPDKREPSFSVPDWVTIPEFLAPHLAARKGGGADR
                     FPYQVKSSLHFSNGGGVYLADRKDDGEEVVLKEARPFAGLDRDEIDAVDRLRWEHEVLE
                     RLKGIQGIPATYDRFTVWEHHFLAMEYMPGVSLGSWLARNYPLTRRDCTEDDIVAYTER
                     ALALVDRVARMVDEVHDRRIVFGDLHSMNILVDGDDDKIGLIDFEMATDADSGKRPALG
                     APGFRAPRDRNGFEIDDYAIAVLKLWIFLPLTTLLELAPAKLRGLADFVQRRFDVPEGY
                     ADSIVAELAPRDLPPLSASTELDQEKPDWALVRKQITEGILASASPERTDRLFPGDIEQ
                     FRVGGACFGYGAAGVLHALNAVGGERYPDHERWLLDSIRRDPPDRPGFYDGSYGIAYVL
                     EELGYRDEATKLLAASATLVEQTTDHSLEGGLSGIGLTQLHFAVARKDNEFGRQALATA
                     VRLAEALETAAPPGKFARAGLLNGWSGPALLFVRLFERTREEGWLSFADQALERDIEEC
                     AESDDGSLQVRDGESRTLPYVGVGGAGILMVAEELAKYRPDANSLKSLSGLREACRGEF
                     VIHPGLFFGRCGLMTALSMGSEPEQRVLDTIDLHLSRLAWYAMPYKGGLAFPGNQLLRL
                     SMDVVTGGAGVLLALAATLDGKAVLPFLSPRTTGH"
     misc_feature    10349..10351
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12583..12723
                     /locus_tag="BKN51_RS36495"
     CDS             12583..12723
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030765.1"
                     /locus_tag="BKN51_RS36495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_101613675.1"
                     /transl_table=11
                     /translation="MELVLDLQALEAPEVLEGGHGGGGGGSNLSLLASCNNSTISLLTC
                     H"
     CDS_motif       12583..12645
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MELVLDLQALEAPEVLEGGHG"
                     /locus_tag="BKN51_RS36495_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12646..12723
                     /prepeptide="core"
                     /locus_tag="BKN51_RS36495_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="9.00"
                     /molecular_weight="2250.5"
                     /monoisotopic_mass="2249.1"
                     /core_sequence="GGGGGSNLSLLASCNNSTISLLTCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MELVLDLQALEAPEVLEGGHG"
                     /leader_location="[12582:12645](+)"
                     /alternative_weights="2268.5"
                     /alternative_weights="2286.5"
                     /alternative_weights="2304.5"
                     /alternative_weights="2322.6"
                     /alternative_weights="2340.6"
     gene            12847..14514
                     /locus_tag="BKN51_RS36500"
                     /old_locus_tag="BKN51_36010"
     CDS             12847..14514
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633046.1"
                     /locus_tag="BKN51_RS36500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_36010"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_101611920.1"
                     /transl_table=11
                     /translation="MAGSADRLLVTVTALDRPRLIALIFCALAGTAAGLLLPGALAAAV
                     DAVVAGRPSLPEVSWLIVLGVTEIAVGLIGGILTARMTAYATAWLRRELTDRYLALGTR
                     SAFADGDAISRLTSDCTGAGMVASVVVQLGSTTLISGGAVVLLALMDWRLALVFLASIP
                     FGLMLARTHLKNTADDVLTYQEVSGELAARMIDAVAGLRTIAASGTADREAERVLRPLP
                     KLSLAGRGMWRTQARMVWRSGLLLPAAELAVLAAAGFGVMEGRLSVGQVLAALGYVALG
                     MGLITQIPLLTTLSRARSCAERINAVRESPVPEPGALGVVPGRGTLELRGVTVEGALRD
                     VDLLVRGGRFTAVVGRSGAGKSVLVNVLGGLVTPDEGMAVLDGRPLEKLRPYELRAVVG
                     FAFERPALLGATIGDAVGYGSWAGEAAVRGACQSAQVDDLIVRLPNGYRTPLSETPLSG
                     GEAQRIGLARAIAHAPRVLILDDATASLDTVTEAAVEEAIERTLPGRTRVVVTHRAATA
                     SRADAVVWLEDGRVRAVGTHAELWRDPAYQAVFTEGAQ"
     gene            14511..16247
                     /locus_tag="BKN51_RS36505"
                     /old_locus_tag="BKN51_36015"
     CDS             14511..16247
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030767.1"
                     /locus_tag="BKN51_RS36505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_36015"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_101611921.1"
                     /transl_table=11
                     /translation="MSVWGLYRSALAGQWRGGLVLLACSVLESAPAFLSGRLVELAVDE
                     GFAADRPGTGLRWLAIFGLVAVIGALGSRLVWHQLGKVVEPLRDALVTAVVRGVLRDPA
                     PPRNQPDASGVARITQHVEVVRDATAGLLVQARGMIVTTVAALAGLFTVAGSLALIVAI
                     PVVVAVLVFACLLPSLARRQRALALADERTAEVAGASLSGMRDVVACGAEPLAALELYD
                     AVDTQAKAAVRVARSGAARSVVIAIGAFVPLLLALLVAPGMVKDGSLTAGAALGALVYL
                     ATTMQPALQGLAATASTVVLRLIVALRRLAETAEAEPEADGTAEPDGTAIYVRDLTFSW
                     GAAAEPVVRGLDLHLRPGERLAVVGPSGIGKSTLAGLLTGMLEPQAGRVLLGGVPVREI
                     PAALRHRMVALIPQEAYVFAGSVRDNVGLFAQAAMDGELRAAVAAVGAEPLVKRLGGLD
                     GEIGHGTLSAGEAQLIALARVYASDAGIVVLDEATSHLDPPAEARAERAFAERGGVLVV
                     IAHRLTSALRADRVLVMDGKETALGTHLELMDRSTRYAQLMHAWSPRLPQPSAQFFQRA
                     PE"
     misc_feature    16203..16205
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16203..16622)
                     /locus_tag="BKN51_RS36510"
                     /old_locus_tag="BKN51_36020"
     CDS             complement(16203..16622)
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330831.1"
                     /locus_tag="BKN51_RS36510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_36020"
                     /product="thioesterase family protein"
                     /protein_id="WP_168214469.1"
                     /sec_met_domain="4HBT_2 (E-value: 4e-15, bitscore: 55.3,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNAEYPHWQTVPLRWKDNDVYGHVNNVVHYSVMDTVINTWLIER
                     GGLDIETGGVIGLCVESQCKYHASVSFPGELEVGLRVGHLGRSSVRYEVGMYSKETVIA
                     EGHFVHVFVDRESRRPVAVDGLLRSALEELRTGLG"
     gene            complement(16616..17848)
                     /locus_tag="BKN51_RS36515"
                     /old_locus_tag="BKN51_36025"
     CDS             complement(16616..17848)
                     /EC_number="1.1.99.24"
                     /GO_function="GO:0004022 - alcohol dehydrogenase (NAD+)
                     activity [Evidence IEA]"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0047988 - hydroxyacid-oxoacid
                     transhydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020642937.1"
                     /locus_tag="BKN51_RS36515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_36025"
                     /product="hydroxyacid-oxoacid transhydrogenase"
                     /protein_id="WP_101611922.1"
                     /sec_met_domain="Fe-ADH (E-value: 4.3e-104, bitscore:
                     347.2, seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYGAGSSDEIGYDLTQYGARRVLVLTDAGVAATGWPQRIAEGIE
                     TYGIEAVVFDGVHVEPTDVSMRKAVDFARGQGQWDAFVAVGGGSAIDTAKAVNLLTSND
                     GDLLDYVNAPVGGGRAPSAPLKPLVAVPTTTGTGSESTTVCVLDVLSLRVKSGISHLRL
                     RPSLAVVDPRLTVSQPPEVTAASGMDILCHAAESYTAKPYTEFDRKRPEDRVPYCGANP
                     LADMFAEQSLRLLSWALPAAVREGSDMKAREAMALAATFAGLGFGNAGVHIPHANAYPI
                     AGQVREFHPGGYPGDEPMVPHGMAVSLTAPAAFRFTFDAAPDRHLRVARLLAPDYEWPG
                     DLQDHLPAVLRQIMQEIGIPNGIGDVGYTESDVDSLVSGTVKQQRLLATAPREASEEDL
                     AGILRDSVTLW"
     misc_feature    complement(17867..17878)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.47"
                     /tool="antismash"
     gene            18020..19681
                     /locus_tag="BKN51_RS36520"
                     /old_locus_tag="BKN51_36030"
     CDS             18020..19681
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009071745.1"
                     /locus_tag="BKN51_RS36520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_36030"
                     /product="thiamine pyrophosphate-dependent enzyme"
                     /protein_id="WP_255414876.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-36, bitscore:
                     124.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.8e-34, bitscore:
                     115.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYQPGASVAQTAVRILTEAQIHRVYAVAGESFLDLLDALQRERS
                     ITFVSARHDSGAAFMAEAEGKLTEHPAVLLAGRGPSAANLAIGVSTAYQDESPMVVLLE
                     NPPSSPGPTSELPTADLTAMFEPLVKWLGRAESPDEVPGLLVEALTRCREGRPGPTVVA
                     VPADFWGVPFDSAKPVAAVKPPATGALGRTAEAVAQLVDEARYPVVIVGGRARAGREEL
                     IAVADELALPVYNAFRRQDAFPENHARYAGHLGIGIPARQLDALERADLVLALGTQLDE
                     VTTQSFRYPTPSQTLVLVGTGIEPARRGGLTFRVDSEVEPFLRELRTVASPRTRRASAA
                     NAAVHTFMTPPDTSGATRVHPADVIRAVRKLAPEDAIVTSDAGNFAQFMHRYWCFTAPR
                     SQLGPSNAAMGYAVPAAVAAKLAEPRRTVIAMAGDGGALMTGQEIETAVRYRVPVTVLV
                     FQNGLHGPLAVHQARKHGRLSGVTVPITDFASWARGLGAAGYTVDDREELEPIIASALV
                     RQRPCVIDIRTDPDVVTPDIRLTSLLGAARPQQGGQ"
     gene            19959..20129
                     /locus_tag="BKN51_RS43685"
     CDS             19959..20129
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163371.1"
                     /locus_tag="BKN51_RS43685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_168214470.1"
                     /transl_table=11
                     /translation="MADETKPQDKSVSGVVPVQFSADAETHDVAVMATNREVLRRSPFG
                     ADVPLRAASGE"
     misc_feature    20293..20308
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.51"
                     /tool="antismash"
     gene            20363..20566
                     /locus_tag="BKN51_RS36525"
                     /old_locus_tag="BKN51_36035"
     CDS             20363..20566
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222289.1"
                     /locus_tag="BKN51_RS36525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_36035"
                     /product="cold-shock protein"
                     /protein_id="WP_037319152.1"
                     /transl_table=11
                     /translation="MTQGTVKWFNSEKGFGFITPDNGGGDVFVHYSEIKGNGFRTLEEN
                     ARVEFEIGQGAKGPQATSVNVI"
     gene            complement(20653..21315)
                     /locus_tag="BKN51_RS36530"
                     /old_locus_tag="BKN51_36040"
     CDS             complement(20653..21315)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013678216.1"
                     /locus_tag="BKN51_RS36530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_36040"
                     /product="response regulator transcription factor"
                     /protein_id="WP_101611924.1"
                     /transl_table=11
                     /translation="MTTLFIVDDQAMVRESFASLLDAQPGLDVVGQAGDGLAALAGISA
                     LTRPPDVVLMDIRMPVMDGLEATRRLLEGDGEKPKVIVLTTFHLDEYVYEALRAGASGF
                     LLKDAPSAELVNAIDVVAAGDALLSPAVTKRLIASFVASAPVPRPSPSRFDVLTERERE
                     VLRLIAKGRSNPEIAADLVLSAQTVKTYVGRILAKLSLRDRAQAIVLAYETGLVGPG"
     misc_feature    complement(21880..21894)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    complement(22501..22516)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.74"
                     /tool="antismash"
ORIGIN
        1 gccttcggcg ggctggaggc cgcggtccgg cgtgccaagg ccgccgcggg cgacaaggac
       61 gtcctggtga tgggtacgga cgtcgccggg caggtgctcg ccgcggggct gctcgacgaa
      121 gtccacctcc acctcgcccc cgtggtgctg gggcagggga ccggcctgtt cggcggacat
      181 ctcggcgagc tgatcccgca gggtgaaccc gtcgcggggg ccgctactca cctgcgcttt
      241 cgcgttcggc gcgcagccgg gcccggtgag tgagctcgcc gacgacgcgc tgccacgccg
      301 gtgacgcctc ggagatccgg gaaacgacca gttcgaggta gcccggccgc ccgccgtcgc
      361 cctcgtgacc gacctcccag gcgtccaggt cgtcgatgag ccggtcgagg cgcggatcgc
      421 gcggatccca gccgatcgcc tggtcgcagg cgagatggac gcgcagcgtc tcggggtcgt
      481 cgaaggcggc gttcttctcc cgtagccgct ccggcacgac gtgcgggtcc agcgcgcgca
      541 tcaggatcca cgcgtcgcgt tcgagcagga cccgctgttc gctgaccccc agatcgcgca
      601 tccggtccag gagggcgacc acgccgggag gcaggacgag ccgttcgccg acggccagtt
      661 cggcgatccg gaggcggttc tcggtgagct ggtcgatctt gcgccgcagc tcggcgtcga
      721 tgtcggcgat ggcggcggcg aactcggcgg gccgggcgtg cagcagcgcg tcgatccggg
      781 ccagcggcac cccggcgtcg gcgagggtcc tgatccggat gaggtccacc gccgcctccg
      841 cgctgtaccg gcggtagccg gaggcgtcgc gtccgggctc gggcagcagg ccgacgtggt
      901 gatagtgacg gacggcacgc acggtcaccc cggcggtcgc cgcgagctgg ccgatcgtga
      961 gcacccgttc tccctgtcgc cggaaaccgc cgccgagtct aggagcggtc gatgacatcg
     1021 cggatcgcct gggtcacggc atcgggacgg tcgaagcaga gccggtggtg cagggtgtcg
     1081 gtgaggacgc gctgctcgcc gtaggagacc ctgctcacca gggccgcgtc cattttcgtc
     1141 ttgccgtcgt gcagctcccg ggacagctgt tccggctgag cggggtcgtt gcccacgact
     1201 gtgagtgcga tcacagggac atcgggcagg tcaggcccgg ctcggagctc ggcggcgagt
     1261 tcgaccaggc cggtgcgttc ggcgacgccg gcgcgaagcc agccgtcgct caccttggcc
     1321 tcgaccaggg cttctcgcac gtggtccgga tagccggtgc gcagctcggc gtacgtctcg
     1381 cggaggaccg gacgcagctc gcccagccgg tcgagatcgg gtgccgtccg ctcggcctcg
     1441 gccaggctcg ccgagggagg catgaagtcg tcccaggcgg ggtggagggc gtccagccag
     1501 accaggcccg ccacctcccg cgggtgaagc tgcgcgaacc cgtgcgcgta gaggccgccg
     1561 agggagtgcg ccgccaggac gtacgggccg gggatgtcca gggcgaacag cagctcgcgg
     1621 agctccgtgg ccacctcgac ggcggtgcgc ggcagcggga ggggatcgct gtagcccgtg
     1681 ccgccgcggt cgtagaccac ggcggtggtg aaccgcgcga cctcctgctg gaccccgagg
     1741 tagtccaggc cgaccgcact ggcgcccgga aggaacacga cggccggtcc gccgtcaccc
     1801 gatcggtgca agaagaggcg gcggccgtcg agctcctcga agcccccgat cggcggcgcg
     1861 aaccgggccg gggaagtgct gtcgttcgtc atgtgggaag cctccggccc tgacgctggg
     1921 tcaaggtcaa ggctgcggtc gagatcttcg gcctgacctg cggaaagatg acccgccacc
     1981 aaacttttcc gggacacgac gtgtgcggct cgggaagacc tgcgataatt accggtgaga
     2041 tcggggcatc gaatgggctc agactcgcta tgaagagcag gtaaaaagta tggctcaggg
     2101 cagcgttaag tggttcaacg gcgaaaaggg cttcggcttc atcgctcagg acgacggtgg
     2161 accggacgtt ttcgtgcact actcggagat ccagggcaac ggcttcaagt ccctggacga
     2221 agggcagcgc gtcgaattcg agatcggcca aggtcagaag ggcccccagg cccagcgcgt
     2281 cgtcgccatc tgacgttttt tcacaccgaa ggcccccacc ctctccgggt gggggccttc
     2341 gggcgtttca ggtggtcgac gggagtgtgt ccaggctcat ccgcgggctg gacgacgggc
     2401 tctggagctc gtgttccggc taccgatatc gtcaagggat gcttgtgatc gttcgtgagc
     2461 acgcgtgcgg ccggacacgg tgagccgctc cgccacggag ccggaacagg tcggtcggaa
     2521 ggtgcggctg cgcgaggtcg gcctccgcga ccgccgggtc ctgatgggct tcgaccgcga
     2581 catggcccgt gaggcgacgc cgctgatcgg tggcgggcac cgccattggg cctcgcaccg
     2641 ttcgggttcg gcgggtgacg acattcactt cggcatcgag acggtgcgcg ggcggatgct
     2701 ggtcggctcg gtctgcacca tcggcgcgga cccggtgacc ggcctgttcg gctacggcat
     2761 cgggatcgcc cctcgccacc agcgctgcgg ctacgccacg gacgccatca ccgttctcct
     2821 ggcgcatatg ttcgagcaac gtggcttccg taaatgcgag gtcagcgtgt acggcggcaa
     2881 cctggcgtcc ctttcgctgc acggcggtct gggcttccgc gaggaaggca ggctgcgcga
     2941 caccgaagtg gtgcgcggcg agatcaagta cctggtccgg atggggatca cggccgagga
     3001 attcgccgcg cgcccctccg acggcccgga cgacctcgga cggcgcggtc agcaccggag
     3061 gccccgccgc ggcaagcact ggcgcgcgcc cgccacggtc agcggctgat catcccggac
     3121 tcgtaggcga agacgaccgc ctggacgcgg tcgcggaggc cgagtttcgt gaggatgcgg
     3181 ccgacgtggg tcttcaccgt cccctgcgag aggtacagca gcccggcgat ctcggcgttg
     3241 gacagaccgc gggccagctg ctccagcacc tcgtgttcgc ggccggtgag cagagcgagc
     3301 ctggcgtccg gcgacggcgc gggcaggccg gtgaccacgc ggtcgagcag ccgccgggtg
     3361 acggtgggcg cgagcgtggc ttccccggcg gcgacgacgc ggacgccgga gatcagatcc
     3421 ggtgcgagcg cgtccttgag caggaaaccg ctggcccccg cctggagcgc ggcgtagacg
     3481 tactcgtcca ggtcgaaggt ggtcagcacc aggacgcggg cgcggtgggc cgcggcgatc
     3541 gcggtggtgg cctcgacgcc gtccatctcg ggcatccgga tgtccatgag cacgacgtcg
     3601 ggatcgaggt ccgccaccat cctgacggcc tccgcgccgt cgcccgcctc tccgacgacg
     3661 tcgatgtcgc cggcgttgtc caggatcatc cgcaggccgg tgcgcacgag cgtctggtcg
     3721 tcggcgatga ccacccggat cgtcatgacg gcaggctcgc gcggacggcg aagccgtggt
     3781 ccggacgcgg tcccgcgtcg aaggtgccgc ccagtacgtt cactcgttcc cgcattcctt
     3841 cgaggccgtg cccggtgccg gacggaggtt ccgccgcgac gccgtcatcg gtcacctcga
     3901 tgtccagcgc gccgggcccg tagcgcatca cgatagtcac cgacgcgtcc ggaccggcgt
     3961 gtttcagcac gttcgtcagc gcctcctgca cgatccggta ggccgccagg tccacagtgg
     4021 acggaagtgg ccggggttcc ccttcgacca cgaactcgac cggcgtaccc gcggcgcgga
     4081 tgtcggcggc cagccgcggc aggcgttccg cgccaggctg gggttcccag tccggtgcgt
     4141 cctggccgag cgcgccgagc agccgccgga tctcgctcaa ggcggtccgc ccggtgccga
     4201 cgatggcgtc cagcgcctcc cgcgctcgct cgggccgccg ctccagctcc gcctgggcgc
     4261 cttgggcctg cagcaccacc accgaaagcg cgtgcgcgac gacgtcgtgc agttcgcggc
     4321 tgatccgccc gcgttcggcg gcgacggcca gcgcggcctg ggtgtcgcgc tcgcgctcga
     4381 gatcggcggc ccgctgctcc aggaccgaga gccggatccg gcgctgccgc gtgttcaacc
     4441 cggccagcca agccaccgcg agcgagaggc cgatgcctgc gaacccaccc cagtcctgga
     4501 cctggcgatg gtcgccgtcg aggtcggtgg gtggtgccag ccgatcgatg acgatgatcc
     4561 gcggcggttc cggatccgac gtccgcgagt tcgtttcggc ggcatggaac gaccacgctc
     4621 cggcgacgag caggcccgcc gccaacaggg cgagggaaag ccgacgcgac ccccacgccg
     4681 cgacggagaa gagaccgatc aacgccacga agtcgaccgg gcggagatcg ttgcccatgg
     4741 ccagatgcag gagggagacc accgccccgg ccgcgaacgt gatcgcggga ctgcggtgcc
     4801 ggatcagcaa agaagccaag gacaccaagg aggcaagcca ccactcgaag ccttccgggt
     4861 catcggtggt gaccacagtg gacagtccga tgagtacggt cagcccgagg tccacggact
     4921 tcgggtgact cctgaggatg gccggcacca gccgagccta atcccagatc gggcgtcgcg
     4981 gatccacctc gcggcagacc ccggcatgcg acctgcgaca gacgcgcgaa tacggagccg
     5041 ggtcgcaggc tgatggcgga agatcctcga cagaaacgga atcctcatga gaaggcttct
     5101 cgtcgcactg gtcgccctcg ccgccgtggt gcccatggcg agcccggctt cggcggccgc
     5161 ggcgcccttg acgttgccgc cgccgaccgg tccgcagccg gtcggctcca ccgacctgca
     5221 cctggtcgac tcagcgcgcc aggacccgtg ggtgccgaca ggaccgcgcg aactgatggt
     5281 gtcgatgttc tacccggccc tgctgccgct cggcccgaaa cggccttacc tcactttggc
     5341 cgaggccaag gcgttcctga ccgaatccgg cgtccccgac gtcgatcccg cgcggctctc
     5401 cgggatccgg gccagcgcgc gggtcgacgc cccgcccctg ccgggaaagc gcgcgctggt
     5461 cgtcctgtcg ccgggattcg gcaaaccgcg cacgacgctc accgggctgg cggaagagct
     5521 ggcgagcaag ggtttcgtgg tcgcgctgat cggccacaac tacgaatccc acggcacggc
     5581 cttcccggac ggccgcgtca ccgaatgcgc cgcttgcgga tccgagtcca cgctgatccc
     5641 gccgatccga gccgcggacg tctcgttcgt cctcgacacg ctgaccaggc ctacgtcgcc
     5701 gtggtcccgg ctgatcgacc gagcgcggat cggcatggcc gggcactcca tcggcggcta
     5761 cagcacgccc acggcgatgg tcgccgaccg gcggatccgc gccggcgtcg acatggacgg
     5821 caggctgtgg tcaccggtcc ccgcgtccgg gatcgaccgg ccgttcctgc tgctcggccg
     5881 cgaaagcgag tacaccccgg ccggtccgga cacgacctgg gcgggcagct ggccgaacct
     5941 caccggctgg aaacgctgga tcagtgtcgc gacagccggg cacgcgtcct tcaccgacgt
     6001 cggcccgctc ggcgagcagc tgggccttgc cccgcccggc accctcggtg gcgcccgcgg
     6061 attggcgttg accagggctt acgtctccgc cttcttcgac aagaacctgc gcggcggacg
     6121 tcagccgttg ctggacggac cggtggcggg caaccccgag atcaagttct ggaaccgacc
     6181 ccggtgaggc cggcggaaac ctgccagagc cgcgcggcct caccggtgtc gatcgcgaag
     6241 gggcgcactc ccacccactc gccctcttcg gcgacgatct cggcgacgtc gcagtcctcg
     6301 cagtagagcc cgcccatgtc ggccaaccgt ggtgacgtcg ccgcccagac ctgggtggcg
     6361 gcgccctgct ccggcgactt gaaatccggg tcggcctggt ccccgttctc gtcgatccag
     6421 ccgaactcga ccatctcctc ctgccgcaga tgacgctgca ggggagtgag gatcgcgccc
     6481 ggatgcagac tgaacgcgcg gatcccgtgt tcggcgccga tcgcgtccag ctgcaccgcg
     6541 aacagcacgt tcgcggtctt tgcctggccg taggcgagcc agcggtcgta gccgccctcg
     6601 aactggacgt cgtcccagcg catcggggaa gagtggtgac cggcggagga caccatgacg
     6661 acccgggcac cgccgtccgc tgtcagcgcc ggccaaagcc ggttcaccag ggcgaagtgg
     6721 ccgaggtggt tgatcgcgaa atgcgcctcc cagccgggac cgacccgccg ttccggcgcg
     6781 gccatgatcc cggcgttcgc gatcaggatg tcgacggaac gaccggtgcc gaggaaccgg
     6841 cgggcgaagg tctcgacact cgtcaggtcg gctaggtcga gctcgccgac ctcggtaccg
     6901 gagatcccgg cgagggccgc ctccgcgtcg gccggacggc gggcggggac gaccacgtgc
     6961 gctccggcgt tcgccagggc gcgcgtggtt tccaagccca gtcccgaata tccgccggtg
     7021 acgatggcga gctcgccgga gaggtcgatt ccgcgcagga cctcttcggc ggtgctgcgg
     7081 gcgccgaagc cggagccgat cttgtgctgt gaggtggtca tgcggcgaac gctaggagct
     7141 agagggctct ctaggtcaaa cgctatcgtc gggcacgtga cggaactcgc gatcggcaag
     7201 gtcaccgacc ggacgggcct cagcgtgcac gcgcttcgct tctacgagaa ggaagggctg
     7261 ctcgcggggc cggtgaaacg ggacgcgaac ggccaccgcg tgtacaccga gcacgacgtc
     7321 gaatggatcc tgaactgcac gaagttccgg gcgtccggga tgccgctcgc cacgatccgc
     7381 gagttcgccg agctcgtccg gcaggggccg ggtaacgagg agaagcggct ggacctgctg
     7441 cgggagcatc agaacaccgt ccgcgcccgg atcgccgaac tggccgactg cctggagctg
     7501 atcagcagga aggtcgaggt ttacgaggag catgtcgcgc gggggaccgc tggagatctc
     7561 tggcactgat atgtccacaa tggacaggcg acgccacccg atcggtgcaa cgtttcgcct
     7621 ggccatcggg cggggcggcc cctaggctct cccgcttgtg acctgcgagg tgagacgatg
     7681 aggtccttcg gcgcggtgga tccggtcaag atggcgctcg cgggactcac cacgatgacg
     7741 ctcggaatgg cggcggcgct caacgccgac gccctgccgg tgatcggtgg cggcaccact
     7801 tattcggccg aattctccga cgcgggcggg ctgcacgagg acaacgacgt ccgggtcgcc
     7861 ggggtcaagg tcggcaaagt gtccgagatc gacctcgaag gcgatcgtgt gcacgtctcg
     7921 ttccgggtga aggacgcgtg gctcggcgac gccacgagcg cgtccattca gatcaagaac
     7981 gtcctggggc agaagtactt ggcgctcgat ccgcgcggtg aagcagtcct cgatcccggc
     8041 gacccgattc cgctgcggcg aaccaccgcg ccgtacgacg tccttgaagc gtttcgggat
     8101 ctgtcgaaaa ccgtcgacgc catcgacgtc gaccagctcg ccaagagttt cgacgccatc
     8161 tcggccactt tcgccgacac gcccgccgac gtccgcgccg cactcgacgg gatttcgaag
     8221 ctgtccggca ccatcgcctc ccgcgatcgg cagctccgga cgctggtggc gaacacgcgg
     8281 caggtctcgc agaccctcgt cgaccgcgac accgaggccc agcggctgat ccaggacggc
     8341 aacacgctgc tgcgcgcgat ttccacccgg cagcaggcga tcaaggacct gctcgacgga
     8401 tcgaaacggc tcgcgaccgc gctcgacggc atcatcgccg acaacgacgg gcaactaggg
     8461 ccggttctcg agcaactcga ccggctgacg tcgatgctcc agcgcaacca ggactcgctg
     8521 gccaagggca tcgcggcgtt cgctccggcg atccgcgtgc tcaccaacgt cgcgggcaac
     8581 gggcactgga tcgacggcta cctgtgcggg ctcgtcctgc cgtcgttcgg tccgatcaac
     8641 gagaagggct gcttcgagaa gtgacccacc tcgtgagcgg taaggacggc gggtctctca
     8701 gcggccgatg ttcccaatgt ggcattgggg acgctgagtg tctccaatgt ggcattgggg
     8761 gcatcgatcg cgaagcggtc gctagggctt cgtccgtcgc agccagaaca gtccgaccac
     8821 cggcagcacc agcgggatga acagatagcc ctgtccgtac accgaccaca cggtcgcgtg
     8881 cgggaaggcc tcgcggtcga aaagactgaa cgtcccgacg gtcagcacgc cgagcagttc
     8941 gatcccgcag gcgaccagcg cgatccgcca ccatcccgcg ccgcggcggg ccagggcgac
     9001 ggtggccagg aggtagacga cggccgcgaa ggcggagagg gcgtaggcca gcggggcctc
     9061 gccgaacttg gtgctgatct gcacggcggc gcgtgacgtc gccgccagtg cgaagatcgc
     9121 gtagacggcc accaggatgc gtcccgggcc ggaggctttg tccgtacggg tgtcggtagc
     9181 ggtgtccacc gtgttctcct cggtttcttc aggcactcgc gcccgcccac acctcgtgca
     9241 gccggagcac catcaccggg atggcgaggc aggcgatccc gaggatcgcg gtgctcgacc
     9301 gcgtgcgctc ggccagcgcc cagaacgtcc cgagcgggag tacgaccagg gagccgatca
     9361 ggtaggcgag ataggtggcc atgctgccgg ggcggccgcc gtcgatcagc agcacgacgc
     9421 cgatgacgag ctgggccacc aggaggagtt cgacgacggc gaggccggcg agcagcgggt
     9481 tgtccggcag tttcctgcgc gcggactgca cgaaactcca caccgcgacc aacgtcgcgc
     9541 aaatcgcgac ggtcaccgcg aagcctgtga tcacgcccgc ctccttaccc gctccaccgg
     9601 cgacaacgta cctccggacg ggtcgcgccc gacgggcgac cggtggggtg cgtggcggag
     9661 gccacggtag cgaccagtgg tccagacctt gggtgaatag atcacgaagc gcgtttgatt
     9721 ggcgttcggc caattcggcc gcgcattatt gtgatcggtg ccgggaccag ggattacgtc
     9781 gcacgtacgt tcctgttaca caccgaccgg gtggttgaaa tccctgttga tctcacgctg
     9841 ggtaccccta ccattcggta ggtttcgaat tcacgtccct gaacagccca tccgaacccc
     9901 cggtatggcg gattggccgt ttgcggtccg gcgggtggaa tattccccat cgcgatggtg
     9961 cacatggccc atccgattgg tgcgaaggag ggggcgctcg atggacgtcc ggtacgaagc
    10021 gtattgcttc gccgatcccc tgttcttcga tgagcagcgg gaaaccgggg acgccgccga
    10081 cgatttcgcc tccctgttgc ccgctcccga gtcgggctgg cggaccgggg tgcgcggagt
    10141 gtggcgcatg atgcaccctc ttgctcgaaa ccttcccttg cagggctgga aaatccacgt
    10201 gtccgcaggt ctgggcaacg ctgagcgggt gctcgtgaag gtgcacgagc attgtcttga
    10261 gcacaatctg tcgtacaagc acctgcgctc gcggagcact ctgctcgccc gaaattccaa
    10321 atatgccccg cgcgacggaa gcggcaagtt actgactctt tatccagctg acaacaacga
    10381 gctcgagcgc gttctcgtcg agttgtccgc gaagctcgac ggtgagcccg gtgcgtacat
    10441 tctcagtgat ctccggtacg gtgccgggcc gctctacgtc cgctacggcg gattcgccga
    10501 gcaatgggtc gaactcgacg gaaaacgtgt cctggcggtg cgcaaaccgg acggaacgct
    10561 ggtcccggac aagcgcgagc cgtccttctc cgtacctgac tgggtgacga ttccggagtt
    10621 cctcgcgcct catctcgcag ctcgcaaggg cggcggcgcg gatcgattcc cctatcaggt
    10681 gaagagttca ctgcacttct ccaacggcgg tggggtgtac ctcgccgacc ggaaggacga
    10741 cggcgaagag gtggtcctca aggaggccag gccgttcgcc ggcctcgacc gcgacgagat
    10801 cgacgccgtc gaccgtctcc gctgggagca cgaggtgctg gagcggctga agggcatcca
    10861 gggcatcccc gcgacctacg accggttcac cgtttgggag caccacttcc tcgccatgga
    10921 gtacatgccg ggtgtctccc tcggcagctg gctcgcccgc aactacccgc tcacccggcg
    10981 ggactgcacc gaggacgaca tcgtcgccta caccgaacga gccttggcgc tggtcgaccg
    11041 cgtggcgcgg atggtcgacg aggtgcacga ccggaggatc gtcttcggcg atctgcactc
    11101 gatgaacatc ctggtcgacg gcgacgacga caagatcggg ctgatcgact tcgagatggc
    11161 cacggacgcc gacagcggca aacggccggc gctcggcgca cccgggttcc gcgccccgcg
    11221 ggaccggaac gggttcgaga tcgacgacta cgcgatcgcc gtgctgaagc tgtggatctt
    11281 cctgccgctc accacgctcc tcgaactcgc cccggcgaag ctgcgggggc tcgcggactt
    11341 cgtccagcgg cgtttcgacg ttccggaggg ctacgccgac tcgatcgtcg ccgagctcgc
    11401 gccgcgcgac cttcctccgc tcagcgcgtc gaccgagctc gaccaggaaa aacccgactg
    11461 ggcgctcgtc cgcaagcaga tcaccgaagg gatcctcgcc tccgcgagcc ccgagcgcac
    11521 cgaccggctc ttccccggcg acatcgagca gttccgcgtc ggcggagcct gcttcgggta
    11581 cggcgcggcc ggtgtcctcc acgccctgaa cgccgtcggc ggtgagcggt atcccgatca
    11641 cgaacgctgg ctgctggact cgatccgccg cgatccgccg gatcgcccgg ggttctacga
    11701 cggctcgtac ggaatcgcgt acgtcctcga agagctcggg taccgcgacg aggcgaccaa
    11761 gctgctggca gcgtcggcga cgctggtcga gcagaccacc gaccacagcc tcgaaggcgg
    11821 cctgtccggc atcgggctca ctcagctgca cttcgcggtg gcccgcaagg acaacgagtt
    11881 cggcaggcag gcgctcgcca ccgcggtccg cctcgccgag gcgctcgaga ccgccgcccc
    11941 gcccggcaaa ttcgccaggg caggcctgct caacggctgg tccgggccgg cgctgctctt
    12001 cgtccggctg ttcgagcgca cccgcgaaga gggctggctg tccttcgccg accaggcgct
    12061 ggagagggac atcgaggagt gcgccgagtc cgacgacggc tccttgcagg tccgcgacgg
    12121 cgagtccagg acgttgccct acgtgggtgt cggcggcgcg gggatcctca tggtcgccga
    12181 ggagctggcg aagtaccgcc cggacgcgaa ctcgttgaag agcctgtccg gccttcgcga
    12241 agcttgccgt ggcgagttcg tcatccaccc cggtctcttc ttcggccgat gcgggctgat
    12301 gaccgcgctc tcgatgggtt ccgaaccgga acagcgcgtc ctcgacacca tcgacctgca
    12361 tctttcccgg ctggcctggt acgcgatgcc gtacaagggc ggcctggcgt tccccggcaa
    12421 ccagctgctc cggctgtcga tggacgtcgt caccggcggc gcgggcgtgc tcctcgccct
    12481 cgccgcgacc ctcgacggga aggccgtgct gcctttcctg tcccccagga ccaccggcca
    12541 ctgacggccg gcggaaataa gtaaccgatg aaagggaaca ccatggaact ggttctcgac
    12601 ctgcaggccc tggaagcccc cgaggttctc gaaggtggcc acggcggcgg cggcgggggc
    12661 agcaacctga gcctgctcgc ttcctgcaac aacagcacca tcagcctgct gacctgccac
    12721 tgatctccgg cacatcgcta gctgatcact gaaggtgcgg gagcggcaca ggccaagtgc
    12781 gccgctcccg cgcttttcat tttgccttcc ggttcgtctc gatgggatca cggattgagg
    12841 agtggaatgg cggggtccgc cgatcggctg ctggtcacgg tgaccgcgct cgatcgtcct
    12901 cgcctgatcg cgctgatctt ctgtgcgctc gccgggaccg cggcgggact gctcctgccc
    12961 ggcgcactgg ccgcggcggt cgacgccgtg gtggccggac gccccagcct tcccgaggtc
    13021 tcctggctga tcgtcctcgg tgtcaccgag atcgcggtcg gcctgatcgg cgggatcctg
    13081 accgcgcgga tgacggccta cgcgaccgcg tggctgcgcc gcgaactcac cgatcgctat
    13141 ctcgcgctcg gcacccgctc ggccttcgcc gacggcgacg cgatcagcag gctcaccagt
    13201 gactgcaccg gtgccggaat ggtcgcctcg gtcgtcgtcc agctcgggtc gaccaccctg
    13261 atctccggcg gagccgtcgt cctgctcgcg ctgatggact ggcggctcgc gctcgtcttc
    13321 ctcgccagca tcccgttcgg gctgatgctg gcgcgcacgc atctgaagaa caccgccgac
    13381 gacgtcctga cctatcaaga ggtctccggc gaactggcgg cgaggatgat cgacgccgtc
    13441 gccgggctcc gcacgatcgc cgcgtcgggc accgccgacc gcgaggccga acgcgtgctg
    13501 cggccactgc cgaaactgag tctcgccggc cgggggatgt ggcggacaca ggccaggatg
    13561 gtgtggcgct cgggcctgct gctgcccgcg gcggaactcg cggtgctggc cgccgccggt
    13621 ttcggcgtga tggaaggcag gctgtccgtc ggacaggtcc tcgcggcgct cggctacgtc
    13681 gcgctcggca tgggcctgat cacccagatt cctttgctca ccacactttc ccgtgcgcgg
    13741 tcgtgcgcgg agcggatcaa cgcggtacgc gaatcgccgg tccccgaacc gggtgccctg
    13801 ggcgtcgtcc ccggacgggg cacgctcgaa ctgcgcggcg tcaccgtcga gggcgcgctg
    13861 cgggacgtcg acctgctcgt gcggggtggc cggttcaccg cggtcgtcgg gcgctccggc
    13921 gccgggaagt ccgtactggt caacgtcctc ggcgggctgg tgaccccgga cgaggggatg
    13981 gcggtgctcg acggccgtcc gctggagaag ctgcggccct acgagctccg cgcggtcgtc
    14041 gggttcgcct tcgaacgtcc cgcgctgctc ggcgcgacca tcggcgacgc cgtggggtac
    14101 ggctcgtggg ccggtgaggc cgccgtgcgc ggtgcctgtc agtccgcgca ggtcgacgac
    14161 ctgatcgtcc ggctgccgaa cggataccgg acgccgcttt cggagacgcc gctttccggc
    14221 ggggaggcgc agaggatcgg gctggcgcgc gcgatcgcgc acgcgccgcg ggtgctcatc
    14281 ctcgacgacg ccaccgccag cctcgacacg gtcaccgagg ccgccgtcga ggaagcgatc
    14341 gaacgcaccc tgcccggccg gacccgggtg gtggtgacgc atcgcgcggc caccgcctcg
    14401 cgggcggacg cggtggtgtg gctggaagac ggccgggtcc gcgcggtcgg cacgcacgcc
    14461 gagctgtggc gggacccggc ttaccaggca gttttcaccg agggcgcgca gtgagcgtct
    14521 ggggtctcta ccgttcggcg ctggccgggc agtggagagg cgggctggtc ctgctggcct
    14581 gctccgtact ggagagcgca cccgcgttct tgtccggtcg cctggtcgaa ctcgcggttg
    14641 acgaggggtt tgccgcggat cggccaggca ccggactgcg ttggctcgcg atcttcggcc
    14701 tggtcgcggt gatcggcgcc ctcggttcac ggctggtgtg gcatcagctc ggcaaggtcg
    14761 tcgagccgct gcgcgacgcg ctggtgaccg ccgtcgtccg cggggtcctg cgcgatccgg
    14821 cgccaccgcg gaaccagccg gacgccagcg gcgtcgcccg catcacccag cacgtcgaag
    14881 tggtccgaga cgccacggcc gggctcctgg tgcaggcgcg cgggatgatc gtgacgacgg
    14941 tggcggcgct ggccgggttg ttcaccgtcg ccggttcgct cgcgctgatc gtcgcgatcc
    15001 cggtggtggt cgcggtcctc gtgttcgcct gcctgctgcc gtcactggcc cgccgtcagc
    15061 gcgcgctcgc gctggccgac gagcggaccg ccgaggtcgc gggcgcgtcg ctgtccggta
    15121 tgcgcgacgt cgtcgcctgc ggcgcggaac cccttgccgc gcttgagctc tacgacgccg
    15181 tcgacacaca ggcgaaggcg gccgtgcggg tggcgcggtc cggggcggcc cggtcggtgg
    15241 tgatcgcgat cggcgcgttc gtgccgctgc tgctggcgtt gctggtggcg ccgggcatgg
    15301 tcaaggacgg ctcgctcacg gccggggccg cgctcggcgc gctcgtctac ctggcgacga
    15361 cgatgcagcc ggcgctgcag ggccttgccg cgaccgcgag caccgtggtg ctgcggctga
    15421 tcgtcgcgct gcggcggctg gcggagaccg cggaggccga gccggaggcc gacggcacgg
    15481 ccgaaccgga cgggaccgcg atctacgtgc gcgacctgac cttcagctgg ggcgcggcgg
    15541 cggagccggt ggtgcggggt ctcgacctgc atctgcggcc cggcgagcgg ctcgcggtgg
    15601 tgggaccgag cggaatcggc aagtcgacac tggccgggct tttgaccggg atgctcgaac
    15661 cgcaggcggg ccgggtgctg ctcggcgggg tcccggtccg ggagatcccg gcggcgctgc
    15721 ggcaccggat ggtcgcgctg atcccgcagg aggcctacgt cttcgcggga tccgtgcggg
    15781 acaacgtcgg cctgttcgcg caggccgcga tggacggcga actgcgggcg gcggtggcgg
    15841 ccgtcggcgc ggaaccgctg gtgaagcggc tgggcgggct cgacggcgag atcgggcacg
    15901 ggacgctgtc cgccggtgag gcgcagctga tcgcgctcgc gcgggtgtac gcgagcgacg
    15961 cgggcatcgt cgtcctcgac gaggcgacgt cgcacctcga cccgcccgcc gaagcccgcg
    16021 cggaacgggc gttcgccgag cggggcgggg tgctggtggt gatcgcgcac cggctgacgt
    16081 cggcgctgcg cgcggaccgg gtcctggtga tggacggcaa ggaaaccgcc ctcggcaccc
    16141 atctcgaact catggaccgg tccacgcgct acgcccagct catgcacgcg tggtcgccgc
    16201 ggttacccca gcccagtgcg cagttcttcc agcgcgctcc tgagtaggcc gtcgacggcg
    16261 accgggcgcc gggactcgcg atcgacgaag acgtgcacga agtggccctc cgcgatcacc
    16321 gtctccttcg agtacatccc gacctcgtag cggacactcg accggccgag atgccccacc
    16381 cgcaggccga cctcgagttc tcccgggaac gacaccgaag cgtggtactt gcactgcgat
    16441 tccacgcaca gcccgatgac cccgccggtt tcgatgtcga gcccgccgcg ttcgatcagc
    16501 cacgtgttga tcacggtgtc catcaccgaa taatggacga cgttgttgac gtgcccgtag
    16561 acgtcgttgt ccttccaccg caacggaacc gtctgccagt gcgggtactc ggcgttcacc
    16621 acagcgtcac cgaatcccgc aggatcccgg cgaggtcctc ttcggacgcc tcgcgcggcg
    16681 ccgtcgccag cagtcgttgt tgtttcaccg tgccggaaac cagggagtcc acatcggact
    16741 cggtgtagcc gacgtcgccg atcccgttgg ggatcccgat ctcttgcatg atctgccgca
    16801 gcacggcggg caggtgatcc tgcagatcgc ccggccattc gtagtccggc gcgagcagcc
    16861 gggccacccg caggtgccgg tccggcgcgg cgtcgaaggt gaagcggaac gccgcgggtg
    16921 cggtcaaaga caccgccatc ccgtgcggca ccatcggttc gtcacccgga tagccgccgg
    16981 gatggaattc ccggacctgc ccggcgatcg gatacgcgtt ggcgtgcggg atgtgcacgc
    17041 ccgcgttgcc gaacccgagt ccggcgaagg tcgccgcgag tgccatcgcc tcgcgcgcct
    17101 tcatgtccga gccctcccgc acggccgcgg gcagcgccca cgacagcagc cgcaacgact
    17161 gctcggcgaa catgtcggcc agtggattcg cgccacagta aggaacccgg tcctccgggc
    17221 gtttgcggtc gaactcggtg tacggcttgg ccgtgtagct ttccgcggcg tggcaaagga
    17281 tgtccatccc gctcgcggcg gtgacctccg gcggctggga aaccgtcaac ctcgggtcga
    17341 cgacggcgag actcggccgc agccggagat ggctgatgcc gctcttcacc cgcagtgaca
    17401 acacgtccag cacgcagacg gtggtgctct ccgaaccggt cccggtggtg gtcggcaccg
    17461 cgaccagcgg tttcagcggc gcgctcggcg cacggccgcc gccgaccggc gcgttgacgt
    17521 agtccagcag gtcaccgtcg ttgctggtca acaggttcac cgccttcgcg gtgtcgatgg
    17581 ccgatccgcc gccgacggcg acgaaggcgt cccactggcc ctgtcctctg gcgaagtcga
    17641 cggccttccg catgctgacg tcggtcggct cgacgtgcac gccgtcgaag acgaccgctt
    17701 cgatgccgta ggtctcgatg ccttcggcga tccgttgtgg ccagcccgtc gcggcgacac
    17761 ccgcgtcggt cagtacgagc acccgccggg cgccgtactg ggtgaggtcg tagccgatct
    17821 catcgctcga cccggcaccg tatttcaagg ccggtgcgcc gtaagtgaaa actgtttcac
    17881 gtccagcggt ggctgaggtc acgttttcgt gctcccttgc tcgaacacgc tccgatatcg
    17941 gacattctgc cgccccgggg ttgccggaat cgaaagatcg cttgacggca ccgatcaccg
    18001 cccgcctaag ctcgtactca ttagatacca accgggagcg tccgtcgccc agacggccgt
    18061 gcggatcctg accgaggcgc agatccaccg cgtgtacgcg gtggccggtg agtccttcct
    18121 ggatctgctc gacgcgctgc aacgcgagcg gtcgatcacc ttcgtttcgg cgaggcacga
    18181 ttccggcgcg gccttcatgg ccgaggccga aggcaagctc accgagcacc cggccgtcct
    18241 gctcgccggc cgcggcccga gcgcggcgaa cctcgcgatc ggcgtctcca cggcgtacca
    18301 ggacgagagc ccgatggtcg tcctgctgga gaacccgccg tccagccccg gcccgaccag
    18361 cgaactgccc accgcggacc tgacggcgat gttcgagccc ctcgtcaagt ggcttggccg
    18421 cgcggagtcc ccggacgagg tccccggcct gctggtcgag gcgctgaccc gctgccgcga
    18481 agggcggccc gggcccaccg tcgtcgccgt ccccgccgac ttctggggcg tccccttcga
    18541 ctcggccaag ccggtcgccg ccgtgaagcc gcccgccacc ggcgcgctcg gccggaccgc
    18601 cgaggcggtc gcgcagctgg tcgacgaggc ccggtacccg gtggtcatcg tcggtggccg
    18661 ggcccgagca gggcgggaag agctgatcgc cgtcgccgac gaactcgcgc tcccggtgta
    18721 caacgcgttc cgccgccagg acgccttccc ggagaaccac gcgcgctacg ccggccacct
    18781 cggcatcggc atccccgcgc ggcagctcga cgcgctggag cgtgccgacc tcgtgctcgc
    18841 gctcggcacg cagctcgacg aggtcaccac tcagtccttc cgctacccga cgccgtcgca
    18901 gacgctggta ctggtcggca ccgggatcga gcccgcccgg cgcggcggcc tgaccttccg
    18961 ggtcgactcc gaggtcgagc cgttcctgcg ggaactgcgc accgtcgcct cgccgcggac
    19021 acgccgcgcg tcggccgcga acgccgccgt gcacaccttc atgacgccgc ccgacaccag
    19081 cggcgccacc cgcgtccatc ccgccgacgt catccgcgcg gtgcgcaaac tcgcgcccga
    19141 agacgcgatc gtgaccagcg acgcgggcaa cttcgcccag ttcatgcacc gctactggtg
    19201 cttcaccgcg ccgcgcagcc agctcggccc gagcaacgct gccatgggct acgcggtccc
    19261 cgcggcggtc gcggcgaaac tcgccgagcc acgccggacg gtgatcgcga tggcgggcga
    19321 cggcggcgcg ctgatgaccg ggcaggagat cgagacggcc gtccgttacc gggtgccggt
    19381 gaccgtcctg gtgttccaga acggcctgca cggcccgctc gccgtgcacc aggcgcgcaa
    19441 gcacggacgg ctctcggggg ttacagttcc catcaccgac ttcgcgtcgt gggcacgagg
    19501 actcggcgcc gccgggtaca ccgtggacga ccgcgaggaa ctggaaccga tcatcgcgag
    19561 cgcgctggtg cggcaacggc cgtgtgtgat cgacatcagg acggatccgg acgtggtgac
    19621 cccggacatc cggctgacga gcctgctggg cgccgcgagg ccgcagcagg gcggccagta
    19681 gggcgattac cgggcggtac tttttctcag gggatacaca gaaacccttg tggtgccgcc
    19741 ttcacctgct ccaaagggtg ggaatctggt gacgactcgg ccgagtttcg gtcgcggagg
    19801 ccggattttg tcggtcggtc gtggcacaat cgccgcaaca ccgagagtcc gatatggacc
    19861 ggagcggcca tcgggcccgc gaccgttcgc cggtgagttg ttggcacgca gtgtcttgcg
    19921 cagtactacg agcgttgtgt tgacacaggg gagaaaacat ggctgacgag acgaagccac
    19981 aggacaagtc cgtttccggc gtggtgccgg tgcagttcag cgcggacgcg gagacccacg
    20041 atgtggccgt catggccacg aaccgggagg tgttgcgccg ttcgccgttc ggcgccgacg
    20101 taccactgcg cgcggcgagc ggcgaatagc ccccctgaaa agggcatcgt gcggccgcgc
    20161 acacccgggt gatcacgctt gtcggcctgc gtgaggtgtg ctttactgct ccaggtctcg
    20221 atttttgtgt tcgtgttggt tcacgctcgc agaactcagc gggcgtagtg tctcctcgtg
    20281 tttccgggga agcaaaccgt ctggtcatga cccgggctgc cgacgtggct tcctgtttgt
    20341 ttgtgttgca tatggagatt ttatgactca gggcactgtg aagtggttca actccgagaa
    20401 ggggttcggc ttcatcactc ccgacaacgg cggcggcgac gtcttcgtgc actacagcga
    20461 gatcaagggc aacggcttcc gtaccctcga ggagaacgcc cgcgtggagt tcgaaatcgg
    20521 gcagggcgcg aagggtccgc aggccacctc ggtcaacgtg atctgatcca ggttttccaa
    20581 gctgggccgt catcccctcg gggaggcggc cctgctgctt ttcaggggta ttacagccag
    20641 gggtcgttcg tttcagccgg ggccgacgag tccggtctcg taggccagca cgatcgcctg
    20701 cgcccggtca cggagcgaga gcttcgcgag gatccggccc acgtatgtct taacggtctg
    20761 cgccgaaagc accaagtccg ccgcgatctc cggattggac cgtcctttcg cgatcagccg
    20821 cagcacctcg cgttcgcgtt cggtgagcac gtcgaaccgc gacggcgaag gcctcggaac
    20881 aggcgcgctg gcgacgaaac tcgcgatcaa ccgcttcgtg acggcggggg agagcagcgc
    20941 gtccccggcg gcgaccacgt cgatggcgtt caccagttcg gccgacggcg cgtccttcaa
    21001 caggaacccg ctcgcgcccg cccgtagcgc ttcgtagacg tactcgtcca aatggaaagt
    21061 ggtcaagacg atcaccttcg gcttctcgcc gtcgccttcg agcagtcgcc gcgtcgcctc
    21121 gagaccgtcc atcaccggca tccggatgtc catcaggacg acgtccggtg gcctggtcag
    21181 ggcggagatg cccgccagtg cggccagtcc gtcacctgct tggcccacga cgtcgagccc
    21241 gggctgcgcg tccagcaggc tcgcgaagct ttcccgcacc atggcctggt cgtcgacgat
    21301 gaacagcgtc gtcacgctac ccccgtgagt tccagtgtga cggccacccg gaacccgccg
    21361 ccgggcctcg ggccggtctc gcaagtgccc ccgatcagcg taacgcgttc ggctatcccg
    21421 gccaggcccg tgccgtcgtc ggccgagggc gccggaaccc gcgtggcggg cccgttctcg
    21481 acgaggatca cgagcacgtc ccgctcccgc cggacgtcga cgtccacaat ggacccaggg
    21541 ctgtgccggg ccgcgttgct cagcgcctcc tgcaagatcc ggtacgcggc aagggcgatc
    21601 atggccggga cgccgtcgcc gccggtgatc cgggagcgga cgtcgatccc ggaagcccgg
    21661 cagccgtcga gcagtccggg gacctcggcg agccccggct gcggttcgtg ttccggttcg
    21721 gtgtcgtcgt cccgcagcac gccgaccagc cgccgggcct cgtccagcgc ctcgcgggcc
    21781 gcgacgccga gcgcgcggaa ctcctccgcg gtggcctcgt tcacgtccgg gaggcggtag
    21841 cgcgcgctgt cggtgcgcag ggcgatcagc gacaggtggt ggccgatgat gtcgtgcagt
    21901 tccctggcga tcagcgcgcg ttcctgcagc gccgtgcgtt tcgtccgctc ctcgaccgcc
    21961 gtccgctcgg ccgtgtcggc ctgcgtcagc gcccgccgcc gctgctgcat gccgtacccg
    22021 gcgacgatgg tcacggtcac cacgatcagc gacgacacca gtgttttcgt ccccccgcgc
    22081 gggagctggg cgaggccgat cgcggtggtg agcaccaccg cgatgatcga gatccccgtg
    22141 ccctgcccgg gtttcgtcct ggcgagggtc agcgccagca ccgggaggta cgggaggacg
    22201 tgggtctgca gcggccagtc ggacagcgtc gtgccgaacg gcggatggcg cgtggggaag
    22261 agggtggcga tggtggcggc cgccatgccc accgccgcca cccggacggc ggtcagcggg
    22321 aaccgcacga ccagcagcgg tggcacgagc tgcaggagca gcaggaagaa gaccagcggc
    22381 aagctctccg agccgaggta gcgcgcccag gagccgtagg tcaggaccat cagcacggtg
    22441 agtgccgagg cggtgaggac gcccttgatc caggccggcc cgcgccacca ggccgaaggc
    22501 ggttcgagat cggcgtcgcg cccggtgaag agcgcccacc ccag
//
