LOCUS       NZ_CP017780            10390 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Amycolatopsis sp. BJA-103 chromosome, complete genome.
ACCESSION   NZ_CP017780
VERSION     NZ_CP017780.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. BJA-103
  ORGANISM  Amycolatopsis sp. BJA-103
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9488490)
  AUTHORS   Ke,X. and Jia,L.
  TITLE     Isolation and identification of a potent feather degrading rare
            actinomycete Amycolatosis sp. BJA-103 isolated from the rhizomes of
            Valeriana jatamansi Jones with abundant antibiotic biosynthetic
            potential
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9488490)
  AUTHORS   Ke,X. and Jia,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-OCT-2016) College of Life Sciences, Northwest A&F
            Unversity, No.22 Xinong Road, YangLing, Shaanxi 712100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: AUG-2016
            Assembly Method                   :: SMRT v. 2.3.0
            Assembly Name :: version 2.3.0 of the PacBio Single Molecule Real
            Time
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:58:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,631
            CDSs (total)                      :: 8,562
            Genes (coding)                    :: 8,496
            CDSs (with protein)               :: 8,496
            Genes (RNA)                       :: 69
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 31 of 66
            Pseudo Genes (incomplete)         :: 47 of 66
            Pseudo Genes (internal stop)      :: 2 of 66
            Pseudo Genes (multiple problems)  :: 13 of 66
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:43:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6935818
            Orig. end                         :: 6946208
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017780.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from B415, College of Life
            Sciences, Northwest A&F Unversity.
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10390
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="30"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10390
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10390
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5390](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5390)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(301..3090)
                     /locus_tag="BKN51_RS30745"
                     /old_locus_tag="BKN51_30300"
     CDS             complement(301..3090)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631926.1"
                     /locus_tag="BKN51_RS30745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_30300"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_101610962.1"
                     /transl_table=11
                     /translation="MGESGSPARFQLLGPVRLLDGERPVPVGGPGVRGLLALLALKVNK
                     VVGLDEIIDALWGHDPPATARTIVHGNVSHLRRVLRDIQGDHPRGAQILTAPPGYQLTV
                     EPGRIDVHRARSLLERASTEDPDKASELLAEALALWQGPALAGVPGSVRAPELEDLRLA
                     VHGARVDADLELGRHAELIVELSPLVRAKPLAERTAGQLMRALYHAGRRGDALELYRTV
                     SRATLRTLGVEPGADLRWLHERVLNDDLPVKVVEDAKAEAHPVQQLPPAVPSLAGREAD
                     LAWLDDLAERAEAGETAVGVVSGTAGIGKSSLVVWWAHRAARRFPDGILFASLRGFDPQ
                     HPPLEPADLLTQFLFGLGVPADGIPEQVHERIALYRSMIAGRRMLVILDNARSADQVRP
                     LLPPGSRSMTLVTSRSRLDGLAVSNAAKLRVLGTLAPGDAVRLIEELAGPAGFDLNHAL
                     ARLCGYLPLALRIAGARLAASAQWSAQDLVDELGNERTRLAALDVEGPDDGVRAAFDVS
                     FRGLPTDVANTFLRLGVVQVVSAGSHLTAAIGDITVGEARRHLRVLAAHNLLAETGRDS
                     FVPHDLVRLFLRELAENELDEEDREDVLSRSVRFYQAVADRARRKMLRIVDPLDFTDAL
                     SDAQMPPLNSFAEAQDWFTAEWANLLEVLEAARAGGRHDDVWRLARVAHTYRAVYPLLD
                     DWKRLVEIGLEAAERSGDVLGRCWMLISRCAIALTFELPQGCLADAERALELASAIGDN
                     RLMVSANIHLGCALTLLARYDEAIATLRQAVEETDRTGDLELRGQALNNCAEAEKRAGR
                     FIEAIGHQIASLEIDRTLGDESYVVVSLNNLAELSMRIGELAAAERYVWEAVDLTISRR
                     FVLQEGVLRLTLGRVLRAGSDVDGAREQFAIALKILSDANPKLAALVRAELTDLGEGP"
     misc_feature    complement(3808..3817)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.73"
                     /tool="antismash"
     gene            complement(4077..4976)
                     /gene="thpD"
                     /locus_tag="BKN51_RS30750"
                     /old_locus_tag="BKN51_30305"
     CDS             complement(4077..4976)
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005441527.1"
                     /locus_tag="BKN51_RS30750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_30305"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_101610963.1"
                     /sec_met_domain="PhyH (E-value: 3e-32, bitscore: 111.6,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLTDTRVDDSYPTRVTGKPEHLPRTHPTVWGGEADGPIDAATLA
                     NHETRGYTVVDQLLSPGEIQTYWQELVRMSSGDHRDDERVITEAKTGEVRSIFDVHETS
                     ELIAELVRDPRVLDRARQILGSEVYIHQSRVNYMPGFKGTGFYWHSDFETWHAEDGMPA
                     PRAVSCSIALTDNYPFNGGLMVMPGSQRTFVQCAGETPEDNYKSSLKEQRVGVPNEEDI
                     TKLAAEYGIDQFTGQAGSALWFDSNVMHGSSNNITPYPRSNIFIVFNSVENALREPFAA
                     IEPRPAFIAGRDSTPLSR"
     misc_feature    4998..5015
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.39"
                     /tool="antismash"
     gene            complement(5001..5390)
                     /locus_tag="BKN51_RS30755"
                     /old_locus_tag="BKN51_30310"
     CDS             complement(5001..5390)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005165143.1"
                     /locus_tag="BKN51_RS30755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_30310"
                     /product="ectoine synthase"
                     /protein_id="WP_101610964.1"
                     /sec_met_domain="ectoine_synt (E-value: 1.5e-53, bitscore:
                     178.9, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLVRTLDEVTDTDADIKTPNWRSKRIVLAKEGVGFSVHETTLYAG
                     TVNDFWYANHIEAVFITSGEGELENTATGEIFQLKPGTLYLLNDHDKHQVRPKTEIKCV
                     CVFNPPITGREVHDENGVYPLVTEP"
     gene            complement(5425..6675)
                     /gene="ectB"
                     /locus_tag="BKN51_RS30760"
                     /old_locus_tag="BKN51_30315"
     CDS             complement(5425..6675)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (21-357). E-value: 8.7e-73.
                     Score: 237.2. Matches aSDomain:
                     nrpspksdomains_BKN51_RS30760_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033455.1"
                     /locus_tag="BKN51_RS30760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_30315"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_101610965.1"
                     /sec_met_domain="Aminotran_3 (E-value: 6.8e-74, bitscore:
                     247.9, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIFEELESEVRSYSRGWPVVFDRAQGSYLYDEDGKAYLDFFAGA
                     GALNYGHNNPALKRALIDYIARDGVTHALDMFTVAKRDFLETFKEKILAPRELDYKVVF
                     PGPGGANAVEAALKLARKVTGKESVINFTNAFHGMTLGALSVTGNSMKRGGAGVPLVHA
                     TPMPYDNYFDGSIPDFLYFEKLLEDSGSGLNEPAAVIVEGVQGEGGINAARIEWLKALD
                     DLCKKHGILLILDDVQMGCGRTGPFFSFEDAGIKPDIVCLSKSIGGYGIPMALTLIRPD
                     LDVWEPGEHNGTFRGISPAFVTATEALRVYWSDDELEKSTKAKGERIAAAFQGIVEAYP
                     DANLFAKGRGLARGLEFANGDLAGKVCAAAFERGLLMETSGPDGEVMKLLPPLTLTDEE
                     LTKGLSIIDESIATVLN"
     aSDomain        complement(5605..6612)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BKN51_RS30760_Aminotran_3.1"
                     /evalue="8.70E-73"
                     /label="BKN51_RS30760_Aminotran_3.1"
                     /locus_tag="BKN51_RS30760"
                     /protein_end="357"
                     /protein_start="21"
                     /score="237.2"
                     /tool="antismash"
                     /translation="FDRAQGSYLYDEDGKAYLDFFAGAGALNYGHNNPALKRALIDYIA
                     RDGVTHALDMFTVAKRDFLETFKEKILAPRELDYKVVFPGPGGANAVEAALKLARKVTG
                     KESVINFTNAFHGMTLGALSVTGNSMKRGGAGVPLVHATPMPYDNYFDGSIPDFLYFEK
                     LLEDSGSGLNEPAAVIVEGVQGEGGINAARIEWLKALDDLCKKHGILLILDDVQMGCGR
                     TGPFFSFEDAGIKPDIVCLSKSIGGYGIPMALTLIRPDLDVWEPGEHNGTFRGISPAFV
                     TATEALRVYWSDDELEKSTKAKGERIAAAFQGIVEAYPDANLFAKGRGLARGLEF"
     misc_feature    6706..6721
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.5"
                     /tool="antismash"
     gene            complement(6714..7205)
                     /gene="ectA"
                     /locus_tag="BKN51_RS30765"
                     /old_locus_tag="BKN51_30320"
     CDS             complement(6714..7205)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033456.1"
                     /locus_tag="BKN51_RS30765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_30320"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_101610966.1"
                     /transl_table=11
                     /translation="MSGKHLIENPTKADGAALWRIARDSKKLDLNTPYAYLLWCHDFAD
                     TSVVAKVDDTPVGFVIGYRKQDTGFVWQVAVDASQRGKGLAGALLDELFSQLTAQGVRY
                     LETTITPDNEASIRLFASFAKRWNATLERRDLFTAKDFPAEDGTHEQEDLYRIGPLSSQ
                     "
     gene            complement(7421..10390)
                     /locus_tag="BKN51_RS30770"
                     /old_locus_tag="BKN51_30325"
     CDS             complement(7421..10390)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631930.1"
                     /locus_tag="BKN51_RS30770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_30325"
                     /product="patatin-like protein"
                     /protein_id="WP_101610967.1"
                     /transl_table=11
                     /translation="MADAGSPWPQEIRLAMTMVGGASLAVWMGGVATETSHLLHASRTP
                     ESEGPYRALLDLLNATVSLDVLTGTSAGGINAACLGLAEAFRSSPQVLRDTWISTGSLD
                     NLIRDPGEKEPRSLLDGDKVLLADLKDALHRITDKATVKPDCPDITVLLTGTMIDGETT
                     RFDDALGNLVRDTEHRLLFRFDGPLWTDDVVGPLALAARSTASFPGAFELSRMPIGEKT
                     GPLHPDMTRYTDVTRSHWLTDGGVLLNKPLRPALREIFERQSHSDVRRLLLYVVPTAER
                     EAERVEVDPDRPPLLGSAMSKVVGTVLSQTISAELEDLTRHNDAVVRTRGTRVSLASMG
                     VRGGPDALVDQRLMNDYRDRRVQEDATALVREATRRLSLSDVEDPGRQWASGTAAQLRA
                     AAAEGLRDGLPTAPPKDTCELQDLVAFRTTALDDSVATGLQLVNAGFRLDPAPEQAVQL
                     NRCRVLLHEARHKAARGERLAGWVTEQDPPDAKVTLAAWIEGLAKKWAARGRSDTLKEA
                     WPIVVAALRQATPILLPLAQAKPDTEAADTVTTLLAWTGLTSGDDSAGDSVVTSRLVRL
                     HIATRGLLAQAPSVDQRVDLVQVSADSRTLMDMKRRRSWDKLTGMQADYFGAFYKASWR
                     ANDWMWGRVDGAGWLIQCLLDPKRLRLLRDVVGREAFRKQVRETFEKIGWRRPGTEDGL
                     SQEEAESLRAQLAGELAFLGLDGELGDVEKETELPISMPVTAMVLARVRQAEIAREELP
                     CVGLHCGHDAKTAKGNGKPSERFRRLIENEPETDEQTQRAFQACQVSGERFDHERGTML
                     LTKTLVKAGAAGINAAAGATRVPKSVQPAATFAKAASRSAWWITRGAATLPSPWNVLAA
                     LITVLAGFVIGGQGGPVLQWVGVPVAAGAIVFLVVSLMTLRKTWRMVLTVLAVLVGAGL
                     LFAAFLPPVRDPLFGWLGGVVAGWRRGEAPVWWLVVCLLILLPAVWTPLGSVFRRRHRR
                     "
ORIGIN
        1 tgtgcaccgc gagcaccggc tgatctccgc gttcggtcct ctggatgcgg tacttgcacg
       61 cgcaaccacc gcatccagag gactgaacgc gggaaggccg cctggcggcc ggccggtatc
      121 gcccccacct ccaccggccg gaccgccacg agccgctcct ggcggctctt caaacggatc
      181 ccgaagggtc cgcccgagcg ccgatcccta ccgaatgccc ctcccctagg gctcgatcga
      241 cgctgaaacg gaccctacgc gcgcaagagg cgaggccact aagaatccgc taaggatcac
      301 tcacggacct tcgccgaggt ccgtgagttc cgcgcggacc agcgcggcga gcttcggatt
      361 ggcgtcggag aggatcttca gcgcgatcgc gaactgctcg cgggcaccgt ccacatccga
      421 cccggcccgc agcactctgc ccagtgtcag cctcagcacg ccctcctgga ggacgaaccg
      481 cctgctgatc gtcaggtcta cggcttccca gacgtatcgc tcggcggcgg cgagttcgcc
      541 gatcctcatg ctcagttcgg ccaggttgtt cagcgagacg acgacgtagc tttcgtcgcc
      601 gagggtccgg tcgatctcca gcgaggcgat ctggtgcccg atcgcctcga tgaaccgccc
      661 cgcccgcttt tcggcctccg cgcagttgtt gagcgcctgc ccgcgcagtt cgaggtctcc
      721 ggtccggtcg gtctcctcga ccgcctgccg cagcgtcgcg atggcctcgt cgtaccgggc
      781 gaggagagtc agcgcgcagc cgagatggat gttcgccgag accatcagcc ggttgtcgcc
      841 gatcgcgctc gcgagttcca gcgcgcgttc ggcgtcggcg aggcagccct gcggcagttc
      901 gaaggtgagc gcgatggcgc agcgcgaaat cagcatccag caccggccga ggacgtcacc
      961 ggaccgctcg gcggcctcca gcccgatctc gaccagccgc ttccagtcgt ccagcaacgg
     1021 gtacaccgcg cgataggtgt gcgcgaccct ggccagccgc cagacgtcgt cgtggcgccc
     1081 gccggcacgg gcggcttcga ggacctccag caggttcgcc cattccgcgg tgaaccagtc
     1141 ctgcgcttcg gcgaaggagt tcagcggcgg catctgcgcg tcactcaacg cgtcggtgaa
     1201 gtcgaggggg tcgacgatcc gcagcatctt ccgccgcgcc cggtcggcga cggcctgata
     1261 gaaccgcacc gaccgcgaca gcacgtcttc gcggtcttcc tcgtcgagtt cgttctccgc
     1321 cagctcgcgc aggaacaggc ggacgaggtc gtgcggcacg aaggaatcgc ggccggtttc
     1381 ggcgagcagg ttgtgcgcgg cgagcacccg cagatgccgc cgcgcctcgc cgacggtgat
     1441 gtcgccgatc gcggccgtca gatgagaacc ggccgagacg acctggacca cgccgagccg
     1501 caggaacgtg ttcgcgacgt cggtgggaag cccccggaac gagacgtcga acgccgcgcg
     1561 gaccccgtcg tcggggccct cgacgtcgag ggcggccagc cgcgtccgct cgttgccgag
     1621 ttcgtcgacc aggtcctgcg cggaccactg cgcgctggcg gcgagccgcg cgcccgcgat
     1681 ccgcagcgcg agcgggagat aaccgcagag ccgggcgagc gcgtggttga ggtcgaatcc
     1741 ggccggcccg gcgagttcct cgatcagccg gacggcgtca ccgggcgcga gcgtgccgag
     1801 gacacgcagt ttggcggcgt tggacacggc gagtccgtcg agcctggagc ggctggtcac
     1861 cagcgtcatc gaccgcgagc cgggcggcag cagcggccgc acctgatcgg ccgaacgcgc
     1921 gttgtcgagg atcaccagca tccggcgacc ggcgatcatc gagcggtaga gggcgatgcg
     1981 ttcgtggacc tgctcgggga tgccgtcggc ggggacgccg agcccgaaca ggaactgcgt
     2041 gagcagatcg gcgggctcca gcggcgggtg ctgcgggtcg aaaccccgca gcgaggcgaa
     2101 aaggatgccg tcggggaagc ggcgggcggc gcgatgcgcc caccacacca ccaggctgct
     2161 cttgccgatc cccgcggtcc cggagaccac gccgaccgcg gtctcgcccg cttcggcccg
     2221 ctcggcgaga tcgtcgagcc aggcgagatc ggcctcgcgc ccggccaggc tcggcacggc
     2281 gggcggcaac tgctggacgg gatgcgcttc ggctttcgcg tcctcgacga ccttgaccgg
     2341 caggtcgtcg ttcaggacgc gttcgtgcag ccagcgcaga tccgcgccgg gttcgacgcc
     2401 gagcgtgcgc agcgtcgccc gggacaccgt gcgatagagc tcgagcgcgt caccgcggcg
     2461 cccggcgtga tagagcgcgc gcatcagctg accggccgtg cgttcggcga gcggcttggc
     2521 ccggaccagc gggctgagct cgacgatcag ttccgcgtgc ctgccgagtt cgagatccgc
     2581 gtcgaccctg gcaccgtgga cggcgagccg caggtcctcc agttcggggg cgcggacgga
     2641 ccccggcact ccggccagcg ccggtccctg ccagagcgcg agggcctcgg cgagcagctc
     2701 ggacgccttg tccgggtctt cggtggacgc ccgctccagc agcgaccggg cacggtggac
     2761 gtcgatccgg ccgggttcga cggtgagctg gtacccgggc ggcgcggtga ggatctgggc
     2821 gccgcgcgga tggtcgccct ggatgtcccg gagcacgcgc cgcaggtggg agacgttgcc
     2881 gtggacgatc gtgcgggcgg tggcgggcgg gtcgtgcccc cagagcgcgt cgatgatctc
     2941 gtcgagcccg acgactttgt tgactttcag ggccagcagc gcgagcagtc cgcggacgcc
     3001 gggaccgccg acggggaccg gccgttcgcc gtcgaggagc cgcacgggac cgaggagttg
     3061 gaagcgggca ggggaaccgc tttcgcccat gacaaacccc ctcccccgat ctctcccctt
     3121 accggagtag ccaacctacc gcgcgaagac gccgccaacc agaaaacgcg agggaagaga
     3181 gacatagcgg gcggcgaccc cccatgcccc caatgccaca ttggggccac caagcgtccc
     3241 caatgccaca ttgggggctt cggaatcccg gacgctcacg tgagctcagg agaagtgacc
     3301 ggcggactcg tctccccgga agcgcgccag cgcgacgggg agacttcacc ccgcgcgccc
     3361 tctttcaggc cgaaggccca cgaagacgtt ttgtagggcg ccctgaccac gaatccgcag
     3421 cttgaccacc atctggcgcc ctgcgaaacg tcttcgtcag cgcgcggaaa taacctttgt
     3481 gacgtccgcc cagtccctgt atgaccggtc cgatcacgac agccgaaccg ccggcgacgc
     3541 gagggctgtg tggaaatagg gacgttgaac gtccctattt ccacacagcc tcaccctggg
     3601 taacctctcg cgcgctcaac aggcagttcg cgtggctggc ggtgacagat cgtgagcagt
     3661 ggctcgcggt cctccgcggc cgatgttccc aatgtcgcac ttgagacgct gagcgtctca
     3721 aatgcgacat tgggaacatg agactgggaa cagcggagcg gggtgcccgg tggatcgcgc
     3781 gtaccacacc atctttgccc tacccggcaa aaaaataagg ccccgtgcca tcagtcccga
     3841 tctgatggca cggagccggg ggatgtccga tttgggccgc ctgggggcgc gacccacacc
     3901 ggacatcggc gtccacgtcc gtccgggtgg gctcaccccg agcgaagaac ccgttcgtcc
     3961 gtcgacaaca cctacgtgag cgagcccact ggcccgctca cgtaggcgac aacgtaacag
     4021 ggcgcacacc gtcggctaca ggcgccccgt catggccttc gctacctgcg ggttcgtcag
     4081 cgcgacaggg gtgtcgagtc gcggccggcg atgaacgccg ggcgcggttc gatcgcggcg
     4141 aacggctccc gcagcgcgtt ctcgacgctg ttgaacacga tgaagatgtt cgacctcggg
     4201 tacggggtga tgttgttcga cgaaccgtgc atcacattcg aatcgaacca gagcgccgaa
     4261 ccggcctgtc cggtgaattg gtcgattccg tattcggcgg cgagtttggt gatgtcttcc
     4321 tcattgggaa caccgacccg ctgctctttc agcgaactct tgtagttgtc ctcgggggtt
     4381 tccccggcgc attggacgaa ggtccgctgt gaacccggca tcaccatcag cccgccgttg
     4441 aacgggtagt tgtcggtgag cgcgatggag cagctgaccg cgcgcggcgc cggcatgccg
     4501 tcctcggcgt gccaggtctc gaagtccgag tgccagtaga acccggtgcc cttgaagccg
     4561 ggcatgtagt tcacgcggct ctggtggatg tagacctcgg agccgaggat ctgccgggcc
     4621 cggtcgagca cgcggggatc gcggacgagc tccgcgatca gctcgctggt ctcgtggacg
     4681 tcgaagatgg agcggacctc accggtcttg gcctcggtga tgacgcgctc gtcgtcgcgg
     4741 tggtcccccg acgacatgcg gacgagttcc tgccagtacg tctggatctc gccaggcgac
     4801 aacagctggt cgacgacggt gtaaccacgg gtttcgtggt tggcgagcgt ggccgcgtcg
     4861 atgggaccgt cggcctcgcc gccccagacg gtggggtgcg tcctgggcag gtgttcgggc
     4921 ttgcccgtga cacgcgtcgg gtagctgtcg tcgactcggg tgtcggtcag cgtcaatgca
     4981 gtcgcctcct cgagcgattt ttagggttcg gttacgagcg ggtacacgcc gttttcgtcg
     5041 tggacctcgc ggccggtgat cggggggttg aacacgcaga cgcacttgat ctcggtcttg
     5101 ggccggacct ggtgcttgtc gtgatcgttc agcaggtaca acgtgcccgg cttcagctgg
     5161 aagatctcgc cggtcgcggt gttctcgagc tcgccttcac cggaggtgat gaagaccgct
     5221 tcgatgtggt tcgcgtacca gaaatcgttg accgtcccgg cgtaaagcgt ggtctcgtgc
     5281 accgagaaac cgacgccctc cttggcgagc acgatgcgtt tgctgcgcca gttcggggtc
     5341 ttgatgtcgg cgtcggtgtc ggtgacctcg tcgagtgttc ggacaagcaa cggaaaactc
     5401 cttctcgttc tcggttgagg gcggtcagtt caggacggtg gcgatggact cgtcgatgat
     5461 cgacaggccc ttcgtgagtt cttcgtcggt gagcgtcagc ggcggcagca gcttcatgac
     5521 ctcgccgtcg gggccggagg tctccatcag cagcccgcgc tcgaacgcgg cggcgcagac
     5581 cttgcccgcg aggtcgccgt tggcgaactc gaggcccctg gcgaggccgc ggcccttcgc
     5641 gaacaggttc gcgtccgggt acgcctcgac gatgccttgg aacgcggcgg cgatgcgctc
     5701 gcccttggcc ttggtcgact tctccagctc gtcgtcgctc cagtagacgc gcagcgcctc
     5761 cgtcgcggtg acgaacgccg ggctgatgcc gcggaaggtg ccgttgtgct cgcccggctc
     5821 ccagacgtcg aggtccgggc ggatcagcgt cagcgccatc gggatgccgt agccgccgat
     5881 ggacttcgag aggcagacga tgtcgggctt gatgcccgcg tcctcgaagc tgaagaacgg
     5941 gccggtgcgg ccgcagccca tctggacgtc gtcgaggatc agcaggatgc cgtgcttctt
     6001 gcacagatca tccagcgcct tgagccactc gatgcgcgcg gcgttgatgc cgccctcgcc
     6061 ctgcacacct tcgacgataa cggccgcggg ctcgttcagg ccgcttccgg agtcttcgag
     6121 aagtttctcg aaatagagga agtccgggat cgagccgtcg aagtagttgt cgtacggcat
     6181 cggggtggcg tgcaccagcg ggacaccggc gccgccgcgc ttcatcgagt tgccggtcac
     6241 cgagagggca cccagcgtca tcccgtggaa ggcgttggtg aagttgatga cggattcctt
     6301 gcccgtcacc ttgcgcgcga gcttcagcgc ggcctcgacc gcgttcgcgc caccggggcc
     6361 ggggaagacg accttgtagt cgagttcgcg cggcgcgagg atcttttcct tgaaggtctc
     6421 gaggaagtcc cgcttggcca cggtgaacat gtcgagcgcg tgcgtgacgc cgtcacgggc
     6481 gatgtagtcg atcagggccc gcttgagcgc cgggttgttg tgcccgtagt tgagcgcgcc
     6541 ggcaccggcg aagaagtcga ggtaggcctt gccgtcctcg tcgtacaggt agctcccctg
     6601 ggcccggtcg aacaccacgg gccagccacg gctgtaactg cgtacttcgg attcgagttc
     6661 ctcgaaaatg ctcatcacgt tttctttctc cctgggatcc ccggatttac gttctattga
     6721 ctgctgagcg gaccgattcg gtacaggtcc tcctgctcat gcgttccgtc ctcggccggg
     6781 aaatccttgg cggtgaacag atcccggcgt tccaaagtgg cgttccaccg cttggcgaac
     6841 gaggcgaaca accggatcga agcctcgttg tccggcgtga tcgtggtttc gaggtaccgc
     6901 acaccctggg cggtgagctg actgaacagc tcgtcgagca gtgccccggc caggcctttt
     6961 ccgcgctggg acgcgtcgac cgcgacctgc cagacgaagc cggtgtcctg cttccgatac
     7021 ccgatcacga agccgaccgg ggtgtcgtcg actttcgcga cgaccgaggt gtcggcgaaa
     7081 tcgtgacacc acagcaaata ggcgtaaggc gtgttgagat cgagcttctt cgaatcgcgg
     7141 gcgattctcc agagcgcggc accgtctgcc ttggtcgggt tttcgatcaa gtgctttccg
     7201 gacatgtcca agaaacgtac cggaggattc gggcgcggtc agatcagcgc ggcggcggca
     7261 acgcggctac ctgcaacaac cctgaaacac acgtgacaaa ggtaacggta acgtttgaag
     7321 cgcagcactg gtgggtaagg ccgcttcgtc gcggtctcac tggatgtgac gataccaacc
     7381 gttaccactc ggtcgcagga ccaggccaca attcggcggt tcagcggcgg tggcgccgcc
     7441 ggaatacgga acccagcggc gtccagacgg cgggcagcag aatcagcaga cagaccacca
     7501 gccaccagac cggcgcctcg ccgcgccgcc agcccgcgac gacgccgccg agccagccga
     7561 acagcggatc acggaccggt ggcaggaacg cggcgaacag cagacccgct cccaccagca
     7621 cggcgagcac cgtgagcacc atccgccacg tcttgcgcaa cgtcatcagg ctgaccacca
     7681 ggaacacgat ggcgcccgcg gccaccggga cgccgaccca ctgcaggacg ggcccgccct
     7741 ggccgccgat gacgaacccg gccagcacgg tgatcagcgc ggcgagcacg ttccacgggg
     7801 acggcagggt ggccgcgccg cgtgtgatcc accacgcgct gcggctcgcg gccttggcga
     7861 aggtcgcggc gggctggacc gatttcggca ccctggtcgc ccccgcggcc gcgttgatcc
     7921 cggcggcacc cgccttgacc agcgtcttcg tcagcagcat cgtcccgcgt tcgtggtcga
     7981 accgttcgcc ggagacctgg cacgcctgga acgcgcgctg ggtctgctcg tcggtctccg
     8041 gttcgttttc gatcaggcgc cggaaccgtt ccgacggttt cccgttcccc ttggccgttt
     8101 tcgcgtcgtg tccacagtgg aggccgacac agggcagttc ctcgcgcgcg atctccgctt
     8161 ggcggaccct ggcgagcacc atcgccgtca ccggcatgct gatcgggagc tcggtttcct
     8221 tctccacgtc accgagttcg ccgtcgaggc cgaggaaagc gagttcaccg gccagttgcg
     8281 cgcgcaacga ctccgcttct tcctgcgaca ggccgtcttc ggtgcccggc cgccgccatc
     8341 cgatcttctc gaacgtttcc cggacctgct tgcggaaggc ctcccgcccg acgacgtcgc
     8401 gcagcagccg caggcgtttc ggatcgagca ggcactggat cagccagccc gcgccgtcga
     8461 cccggcccca catccagtcg ttcgcgcgcc acgacgcctt gtagaaggcg ccgaagtagt
     8521 cggcctgcat gccggtgagc ttgtcccacg aacggcgccg cttcatgtcc atcagcgtcc
     8581 gcgaatccgc gctcacctgg acgaggtcga cccgctggtc gaccgagggc gcttgcgcga
     8641 gcagcccccg ggtcgcgatg tgcaggcgca ccaggcgcga ggtgacgacc gagtcgccgg
     8701 cgctgtcgtc gccggaggtg agcccggtcc acgccagcag cgtggtgacc gtgtcggcgg
     8761 cttcggtgtc gggtttcgcc tgtgccagcg gcaaaaggat cggcgtcgcc tgacggagcg
     8821 cggcgaccac gatcggccac gcctccttca gggtgtccga ccggcccctt gcggcccatt
     8881 tcttggcgag gccctcgatc caggccgcga gcgtgacctt ggcgtccggc ggatcctgtt
     8941 cggtgaccca gcccgcgagc cgctcgccgc gcgcggcctt gtgccgcgcc tcgtgcagca
     9001 gcacgcggca gcggttgagc tgcaccgcct gctccggcgc cgggtcgagc cggaagcccg
     9061 cgttcaccag ctggaggccg gtggcgaccg aatcgtccag cgcggtggtc cggaaggcca
     9121 ccaggtcctg gagttcgcag gtgtccttcg gcggcgcggt gggcaggccg tcgcgcagtc
     9181 cctccgccgc ggccgcgcgc agctgcgccg ccgtgccgga cgcccactga cggcccggat
     9241 cctccacatc ggacagagag agcctgcggg tcgcctcacg gaccagcgcg gtggcgtcct
     9301 cctggacccg ccgatcgcgg tagtcgttca tcagccgctg gtcgaccagc gcgtccggac
     9361 cgccgcgaac ccccatcgag gcaagggaaa cgcgagttcc cctggttcgg acgacagcgt
     9421 cgttgtgccg ggtcagatcc tcgagctcgg cgctgatcgt ctggctcagg acggtgccga
     9481 cgaccttgct catcgcgctg cccagcagcg gcggccggtc cggatcgacc tcgacccgct
     9541 cggcttcgcg ttccgccgtc ggcaccacgt acagcagcag ccgccggacg tcggaatgcg
     9601 actgtcgttc gaagatctcc cgcaacgccg ggcgcagcgg cttgttcagc agcacgccgc
     9661 cgtcggtcag ccaatgcgac cgggtgacgt cggtgtaccg ggtcatgtcc ggatgcagcg
     9721 gcccggtctt ctcgccgatc ggcatgcggg agagttcgaa cgcgccgggg aacgacgcgg
     9781 tggagcgcgc cgcgagcgcg agcgggccca cgacgtcatc cgtccacaaa ggaccatcga
     9841 agcggaagag gagccggtgc tcggtgtccc gcaccaggtt cccgagcgcg tcgtcgaacc
     9901 tggtcgtctc gccgtcgatc atcgtgccgg tgagcagcac ggtgatgtcg ggacagtccg
     9961 gtttgaccgt ggccttgtcg gtgatgcggt gcagcgcgtc cttgagatcc gccaggagca
    10021 ccttgtcgcc gtcgagcagc gagcgcggtt ccttctcgcc ggggtcgcgg atcaggttgt
    10081 cgagcgaccc cgtgctgatc cacgtgtcgc gcagcacctg cgggctcgac cggaacgcct
    10141 cggccagccc gaggcacgcc gcgttgatgc cgcccgcgct cgtgccggtg agcacgtcga
    10201 gcgaaaccgt ggcgttgagc agatcgagca gggcgcggta cggcccctcg gattccggcg
    10261 ttctcgacgc gtgcagcaga tgtgaggtct cggtggcgac cccgcccatc cagaccgcga
    10321 ggctcgcccc gcccaccatg gtcatcgcca gccggatctc ctgcggccac gggctccccg
    10381 cgtcggccat
//
