LOCUS       NZ_CP017780            22035 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Amycolatopsis sp. BJA-103 chromosome, complete genome.
ACCESSION   NZ_CP017780
VERSION     NZ_CP017780.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. BJA-103
  ORGANISM  Amycolatopsis sp. BJA-103
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9488490)
  AUTHORS   Ke,X. and Jia,L.
  TITLE     Isolation and identification of a potent feather degrading rare
            actinomycete Amycolatosis sp. BJA-103 isolated from the rhizomes of
            Valeriana jatamansi Jones with abundant antibiotic biosynthetic
            potential
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9488490)
  AUTHORS   Ke,X. and Jia,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-OCT-2016) College of Life Sciences, Northwest A&F
            Unversity, No.22 Xinong Road, YangLing, Shaanxi 712100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: AUG-2016
            Assembly Method                   :: SMRT v. 2.3.0
            Assembly Name :: version 2.3.0 of the PacBio Single Molecule Real
            Time
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:58:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,631
            CDSs (total)                      :: 8,562
            Genes (coding)                    :: 8,496
            CDSs (with protein)               :: 8,496
            Genes (RNA)                       :: 69
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 31 of 66
            Pseudo Genes (incomplete)         :: 47 of 66
            Pseudo Genes (internal stop)      :: 2 of 66
            Pseudo Genes (multiple problems)  :: 13 of 66
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:43:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6170519
            Orig. end                         :: 6192554
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017780.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from B415, College of Life
            Sciences, Northwest A&F Unversity.
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22035
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="27"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22035
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22035
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12035](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12035
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(218..232)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            complement(378..2438)
                     /locus_tag="BKN51_RS27125"
                     /old_locus_tag="BKN51_26710"
     CDS             complement(378..2438)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150523.1"
                     /locus_tag="BKN51_RS27125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26710"
                     /product="hydantoinase/oxoprolinase family protein"
                     /protein_id="WP_101610323.1"
                     /transl_table=11
                     /translation="MTGLRVGVDIGGTFTDLCVLDETGVVAVGKVLTTHDEPARAVEEG
                     LRRTLADAGLEAADVEQFVHGTTLVTNALIERKGSRTALLATAGFRDVLEMRREHRYEL
                     YDLLIELPDPLVPRHLRFDVPERILADGTVHTGLDEEYVARLGRELDARGIDAVAICFL
                     HAFTNPAHERRAAEILQDVAPRLRVALSSEVVPEIREFERASTTVANVYVQDLTERYLR
                     DLERRLHAAGVRPSPHIMLSNGGIATVDTAARYPIRILESGPAGGALAASAIGSAAGVE
                     DLLAFDMGGTTAKLCMISGGSPLVTHEFEVDRKYRLLPGSGLPVKVPVTDMIEIGVGGG
                     SIARIDALGLLTVGPDSAGSEPGPVCYGRGGTEPTVTDADLVLGYLDPGYFLGGGMTLD
                     AEGAREAIRSKIAGPLGVSVEEAAWGIHTSVNEDMANAARVHAVERGKDPAKLPMFTFG
                     GAGPVHGVGVARALGAPEVVAPPAAGVLSAAGFLTAPLAFDFVRSARSAVLDLSWEQVD
                     ELFAEMETEGGELLEKSGVDGAKVTHRRIAEMRYSGQGYEIRVPVEPGNWPESLVDAFT
                     GTYRTLYRRTGPDVAIEVLNWRVVSSGPVPEVTLKLAGVVAEGDARKGSRPAYFPAEGG
                     FVDTAVFDRYRLKPGDRVEGPVIVEERESTVVVPPGAHCVVGEDASLVVTV"
     gene            complement(2435..4066)
                     /locus_tag="BKN51_RS27130"
                     /old_locus_tag="BKN51_26715"
     CDS             complement(2435..4066)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631248.1"
                     /locus_tag="BKN51_RS27130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26715"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_101610324.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.2e-56, bitscore:
                     189.1, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-26, bitscore:
                     92.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAPTGAQHLADALTALGTEVVFGLPGVHNLPLWEALADSDIRLI
                     GVRHEQTAGYAADGYARATGKLGVAMVTTGPGAANTLAAVGEAMASAAPMLVIATDIPS
                     TLRRPGVVRGVLHETSDQQAMFAPVTKAGFTVTSADQVAATLHRAARLALQPQSGPVYL
                     GIPTDFLSERTPARRPPRSHARPSEIPDLSEAEALLATAARPLIWAGGGALRAGAGEAI
                     GKLAERLAAPVLTTFGARGLLSVDHPCLAPNPVHAPEVGALWDEADVVLAIGTDFDGLM
                     TQNWLMPQPKKLIAINVDPDDAAKNYQPDITLVGDARVLTEALKVEERPGIAALVGRLA
                     KVSARVRRRIKEEEPQAADLLSTLDEVLPQDAVVVADMCVAGYWIGGFHRVRAPRKLAY
                     PMGWGTLGYGFPAALGAGAAGTGRAICVSGDGGFLFGCGDLATLAQEQLPVTVIIVDDG
                     GYGMLRYDQDRAGLPRRGVDWDSPDFVGLARSFGVHADRVSGFGRAFRRLLGEFVESDE
                     PNVLVVRAKMAPPLNTSPRWYRKGSS"
     misc_feature    complement(3968..3970)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4165..4791)
                     /locus_tag="BKN51_RS27135"
                     /old_locus_tag="BKN51_26720"
     CDS             complement(4165..4791)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033792.1"
                     /locus_tag="BKN51_RS27135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26720"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_101610325.1"
                     /transl_table=11
                     /translation="MSDGFIEVTSEAELREILPPPLERTANKARPALHEMDRRWLAESP
                     FVLIATSAADGTCDVSPKGDPAGFTLVLDDTRIAIPERPGNRRADGFRNVLSNPHVGLI
                     YLIPGRGDTLRINGRARLVREAPFFDDMIVRGNRPRLALVVDIDEIFHHCQKAFMRSKL
                     WSPESWTPGAMPSRAVISKTFERPEDSIAELEAYYEPSKYSAGLY"
     gene            complement(4784..5941)
                     /locus_tag="BKN51_RS27140"
                     /old_locus_tag="BKN51_26725"
     CDS             complement(4784..5941)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150529.1"
                     /locus_tag="BKN51_RS27140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26725"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_101610326.1"
                     /sec_met_domain="DAO (E-value: 1e-69, bitscore: 234.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESLPERTDVVVIGGGIIGVSCAYRLAAAGVSVLLLERDSLGAGS
                     TGKAAGGIRSSFTTHVNIEIGLRGLAEYASFAETYGAEIDFRRDGYLYLVTDPADLPEF
                     ERCAELQNSYGVRSRLVEPAEARRFSPMIDTEGVIAALWSPDDAKATPDSAVQGYARAA
                     RGHGAVLKTGVEVVGIERDGDEITGVRTGDGLVRTDAVVCAAGAWSGRIGEFAGVELPV
                     RPFRRQVVFTGPVAGLPESVPLTIEMPSAFYFHREGLGLAMSFCDGDGDPGFDTRYQPG
                     DWLPKLAEIAARRVPAVLEAGIRSGWAGLYEVTPDRNQIVGESVQVSRFFYATGFSGHG
                     FQMGPAVGELVRDLYLGRVPAIDITGLDVRRFAGDRAATREHNIV"
     gene            complement(5925..6938)
                     /locus_tag="BKN51_RS27145"
                     /old_locus_tag="BKN51_26730"
     CDS             complement(5925..6938)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033794.1"
                     /locus_tag="BKN51_RS27145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26730"
                     /product="glutathione S-transferase C-terminal
                     domain-containing protein"
                     /protein_id="WP_101610327.1"
                     /sec_met_domain="GST_C (E-value: 2.4e-07, bitscore: 29.8,
                     seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIPTDPKTGEFRRSANHFDARVTADGRDGWPVEAGRYRLVVSRA
                     CPWASRGLVVRRLLGLESALSVAVADPIQDDKSWRFTLDPDDRDPVLGIKYLAEAYHAA
                     DPHYMGGISVPAIVDIPSRRLVSNDYPRITLDLSTEWTSLHRPGAPDLYPERLRDEIDD
                     VNVGVFADVNAAVYQAGFATRQRAYEDAYTRLFAMLDALSERLENQRYLVGDTITEADI
                     RLFTTLVRFDPVYHGHFKCNRDKLTELPVLWAYARDLFQTPGFGDTVDFDHIKRHYYGV
                     HEQVNPTRIVPMGPDLSGWATPHHREQLGGRPFGDGTPPGPPPEDERIEATDGVTS"
     gene            7035..8411
                     /locus_tag="BKN51_RS27150"
                     /old_locus_tag="BKN51_26735"
     CDS             7035..8411
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008374 - O-acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631252.1"
                     /locus_tag="BKN51_RS27150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26735"
                     /product="wax ester/triacylglycerol synthase family
                     O-acyltransferase"
                     /protein_id="WP_101610328.1"
                     /transl_table=11
                     /translation="MPFMPVTDSMFLLVETREHPMHVGGLQLFKKPEDAGPDYLRDIRR
                     KLLDSDNMRSVFRRRPARPVNTAGHIAWATDVDLELDYHFRHSALPQPGRIRELLELTG
                     RWHSTLLDRHRPLWEIHLVEGLQDGRFAIYSKIHHALMDGVSALRHLQGTLSDDPNDLD
                     CPPPWGRRAKPDDGRNGKASPSVLQTMGKTFNQLAGIAPAAMKVAREAFQEHTLTLPAQ
                     APKTMLNVPIGGARRFAAQSWSLDRVRKVATAAGVSRNDVVLAMCSGALRDYLMEQNAL
                     PDAPLTAMVPVSLRRKDSGDAAGNNIGALLCNLATDLADPAARLTAINASMRNGKKLFS
                     ELTPLQTLLLSGINVAQLGVSPIPGIVNNTKPPFNLVISNVPGPRKQMYWNGASLDGIY
                     PASVLLDGQALNITLTSNGDNLDFGITGCRRSVPHLQRILTHLDTALAELEHAVSIGRS
                     "
     gene            complement(8475..9461)
                     /locus_tag="BKN51_RS27155"
                     /old_locus_tag="BKN51_26740"
     CDS             complement(8475..9461)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631253.1"
                     /locus_tag="BKN51_RS27155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26740"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_101610329.1"
                     /transl_table=11
                     /translation="MSLRRTLAATFAAATAVSIAAVPAAAAEVPSIQAIRQLAGGLNQA
                     WSIDFLPDGTGLFTQKDAKTISRIDKAGKVTTVQTIPGVSVTAEAGLLGIAVSPKYATD
                     ETVFIYYTTSSDNRIAKLKLGQAPTPIVTGIPRGSQYHHGGRIRFGPDGYLYAGTGDGQ
                     NGANAQNKNSLGGKVLRVTTDGAAAPGNPFNSRVYSYGHRNVQGLTWANGQLYISDIGN
                     NKLDELNKIDPGKNYGWPTCEGPCNTAGMTNPVKAWPTASATPSGLAAYKGSLYMASLK
                     GGTYKLDLNGNGGKLWTNLGRTRDATAGPDGQLYTITPGAIYVSDGS"
     misc_feature    complement(9453..9455)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9772..9786
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            9802..9897
                     /gene="pqqA"
                     /locus_tag="BKN51_RS27160"
                     /old_locus_tag="BKN51_26745"
     CDS             9802..9897
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033797.1"
                     /locus_tag="BKN51_RS27160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26745"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_101613483.1"
                     /transl_table=11
                     /translation="MIEAIEVWTTPDFVEYETPMEVTAYAARMED"
     misc_feature    9816..9831
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.68"
                     /tool="antismash"
     gene            10001..10681
                     /gene="pqqC"
                     /locus_tag="BKN51_RS27165"
                     /old_locus_tag="BKN51_26750"
     CDS             10001..10681
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631254.1"
                     /locus_tag="BKN51_RS27165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26750"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_101610330.1"
                     /sec_met_domain="TIGR02111 (E-value: 4e-84, bitscore:
                     280.6, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSAEFIAALRGLSHRYWGTHPFHHRMHGGELSEHELKIWAANRW
                     YYQCVLPQKDAAIISNCPLPEIRREWLDRIVYHDGTKAGDGGTERWLRLCTAVGLDREE
                     VLDQRHVAPGVRFAVDAYVNFARTKPWLEAVASGLTEMFAGHLMQRRVADMLANYSWIA
                     REDLAYFTNRIDKVSGEGKGTLDIVVRHAVTREQQEKAIAALSFKTDVLWSMLDAIERA
                     AAKE"
     gene            10684..10956
                     /gene="pqqD"
                     /locus_tag="BKN51_RS27170"
                     /old_locus_tag="BKN51_26755"
     CDS             10684..10956
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336984.1"
                     /locus_tag="BKN51_RS27170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26755"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_101610331.1"
                     /sec_met_domain="PqqD_RRE (E-value: 4.4e-25, bitscore:
                     86.2, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7.2e-10, bitscore: 38.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTITTGSVPRLRRGVRLSYDRTRETHVLLFPEGVLVPNPTAAAV
                     LGLCDGAADVAAIAAALRERYTGVREQEILDVLTRLGDRRIVEWT"
     aSDomain        10687..10947
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BKN51_RS27170_PqqD_RRE.1"
                     /evalue="1.40E-27"
                     /identifier="RREFam006.1"
                     /label="BKN51_RS27170"
                     /locus_tag="BKN51_RS27170"
                     /protein_end="88"
                     /protein_start="1"
                     /score="86.2"
                     /tool="antismash"
                     /translation="TTITTGSVPRLRRGVRLSYDRTRETHVLLFPEGVLVPNPTAAAVL
                     GLCDGAADVAAIAAALRERYTGVREQEILDVLTRLGDRRIVE"
     gene            10947..12035
                     /gene="pqqE"
                     /locus_tag="BKN51_RS27175"
                     /old_locus_tag="BKN51_26760"
     CDS             10947..12035
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150538.1"
                     /locus_tag="BKN51_RS27175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26760"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_101610332.1"
                     /sec_met_domain="PF04055 (E-value: 5.4e-21, bitscore: 74.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.8e-05, bitscore: 24.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.1e-08, bitscore: 34.3,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.6e-10, bitscore:
                     38.7, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLNTSTAAPPLGMLAELTHRCPLHCPYCSNPVEMIARDGELSTE
                     EWLSVLSQARELGVLQVHMSGGEPLARPDLPILVEHATKLGCYVNLVTSGLGLTEPRLD
                     DLVERGIAHIQLSVQGATAERADRLAGARAHDRKLVVAGLIKKAGLPLSVNVVLHRQNH
                     DQLAGIIDLAEQMGADRLELANTQYYGWALRNRDALMPTRRQLDEAEPIVRAATERLRG
                     SMEIIYVVADYYEQYPKPCMYGWGARQLTVAPDGNVLPCPASTAIETLTFDNVRDKPLA
                     WIWYESGSFNAYRGEDWMPDTCGTCDRRSIDFGGCRCQAFQLTGDAAATDPVCSRSPRR
                     DVVDLILATPPKTDELVMRGPQ"
     gene            12032..12895
                     /gene="pqqB"
                     /locus_tag="BKN51_RS27180"
                     /old_locus_tag="BKN51_26765"
     CDS             12032..12895
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631257.1"
                     /locus_tag="BKN51_RS27180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26765"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_101610333.1"
                     /transl_table=11
                     /translation="MRVILLGTAAGGGFPQWNCACALCTSDAPPRTQDCVAVSADGESW
                     YLLNASPDIRAQILATPPLRAGPGPREIPLRGVLLTDAELDHSLGLLLLREAGGLPVWA
                     PEAVLGALSEQFPARSIIDGYGGWDWLSNSEIAIDGLRVSALPVSDKRPKYARSSTEDG
                     PWVVAYRIEDVQTGGVFVYAPCLKSWPDGFDAFTEGASLVLLDGTFYAPDEMSGATAAE
                     VGDGAQLAMGHLPITGSLAKLRPGPRWAYTHLNNTNPVVDPSSPEHAAVLDGGASLPLD
                     GTEFEL"
     gene            complement(12892..13866)
                     /locus_tag="BKN51_RS27185"
                     /old_locus_tag="BKN51_26770"
     CDS             complement(12892..13866)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082804.1"
                     /locus_tag="BKN51_RS27185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26770"
                     /product="aldo/keto reductase"
                     /protein_id="WP_101610334.1"
                     /transl_table=11
                     /translation="MRTTTLGRSGLEVSRIAFGTWQLGGDWGSFDEDAAIAAIHHAREL
                     GVDFFDTAQAYGFGKSEAMLGKALREELKRDRDSLVIATKGGIKPRSDRPRDSRREWLT
                     QGIEDSLRFLDVDHIDLYQIHWPDSDAPAEETAGILQEFVDAGKIRHIGVSNYDAAGLA
                     DFDKTRPIETLQPPYHLFRRDIETDPLPYARENDIGVLVYSPLGSGLLTGSFTPETTFE
                     KTDWRSRSSAFTGETFRRNLAIVDKLEEFAADKGISVSQLAIAWTLAQPGVHVAIVGAR
                     KAANIEASLAAADVDLTADELAEIDRLTADAVPVSGASPEGVA"
     misc_feature    complement(13927..13940)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.81"
                     /tool="antismash"
     gene            13975..14493
                     /locus_tag="BKN51_RS27190"
                     /old_locus_tag="BKN51_26775"
     CDS             13975..14493
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005447463.1"
                     /locus_tag="BKN51_RS27190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26775"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_101613484.1"
                     /transl_table=11
                     /translation="MSESPSLDGLRVLAHPVRLRILSLLTGVAMSAAEAARELGETQAN
                     ISYHLRRLHEAGLLDVAEEVRIRGGLAKRYRHDPESGGRFASTNPQEDQILIAAMAEEL
                     KRRGEFRVAGQRGSTTDAEIWVDRETWEKAVEHAHELSKLLHSAARPPRTRGTIPVSAT
                     VSLFEMTRS"
     gene            14490..15710
                     /locus_tag="BKN51_RS27195"
                     /old_locus_tag="BKN51_26780"
     CDS             14490..15710
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631260.1"
                     /locus_tag="BKN51_RS27195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26780"
                     /product="MFS transporter"
                     /protein_id="WP_101610335.1"
                     /transl_table=11
                     /translation="MTSLREPLRHHNFRWLIGGRTFGEFGNAVAPLALAFAVIDLTGSA
                     VDIGIVVGARSVASVVLLLFGGVLADRLPRSVILQGTELAATLTQATIAASVLCGFASI
                     PLLVGLSVVNGAVTAISAPASASLTPLTVPATLLAQANALGRLLSNSGRIAGAGLGGVL
                     VTAVGPGWALGGNALLFLGSALSYRRIRLSRRERVPGSRPLAELAEGWREFRSRTWVWV
                     VVVQFMVVNAVIAGGIAVLGPLVADGTFGRSGWGFAIAAQTIGSLVGGILVARWQPRRA
                     LFVGVAVILFEAPPLILLGQAPWLPLLLAAMFVSGMAIEQFVVAWDVSLQENVPEDKLA
                     RVYSYDMLGSFIALPLGQMAAGPAALHFGVSTTLIACAALVVAATCLALCSGQVRGLVR
                     KTHAAQP"
     gene            complement(15755..17131)
                     /locus_tag="BKN51_RS27200"
                     /old_locus_tag="BKN51_26785"
     CDS             complement(15755..17131)
                     /EC_number="3.5.1.4"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150551.1"
                     /locus_tag="BKN51_RS27200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26785"
                     /product="amidase"
                     /protein_id="WP_101610336.1"
                     /transl_table=11
                     /translation="MNDTKLTASELVAAYATGELSPVEATQNALRVIEERDGETNAYCL
                     VDADGALEQAKASEIRWRDGNPIGWLDGVPASIKDMFLTQGWPTLRGSRCIDPDQPWDV
                     DSPVTARLRENGLVLLGKTTTPELAWKGVTDNTLTGITRNPHDPSTTAGGSSGGSAAAV
                     AAGMGELSVGTDGGGSIRIPASFCGIVGLKPTHGRIPLFPASPFGPLSHAGPMARSVDD
                     TALLLDVLALPDHRDPAALAPPVSTFREAVRRDVRGLNAAYSPTFGYVDVDPEVAAIVK
                     SAVQSLSDAGLHIEETDPGFSDPKPAFDILWSTGAAKWLDTFPAGSDTMVDPGLRKVWE
                     LGKTFSASDYLGANAERAALGILMGEFHTRYDVLITPTLPIAAFEAGHEVPPGSGLSGW
                     PDWTPFTYPFNMTQQPAISVPAGRTSRGLPVGLQIIGPRHSDDLVLAVAKLLEEVRPWP
                     "
     gene            complement(17128..18129)
                     /locus_tag="BKN51_RS27205"
                     /old_locus_tag="BKN51_26790"
     CDS             complement(17128..18129)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336991.1"
                     /locus_tag="BKN51_RS27205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26790"
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="WP_101610337.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 1.8e-51, bitscore:
                     172.9, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPSETPVLAVLCGDARPPDMRAIEAEAVVRYTDEAGLADALSGA
                     DALFVYDFLSTAVPGAWHAADGLRWLHIASAGVDPVLFPGLQASDVVLTNSRGVFDGAI
                     AEYVLGVVLAFAKDFVRSWDLQRRKQWKHRESERISGRRVLVVGTGPIGRSIARSLRAA
                     GMSVAGVGRRPREDDPDFGDVFSSSDLARHLPEADYVVAVAPLTEQTKGMFDAEAFAAM
                     KPGARFVNVGRGELVVTSDLVGALRDGPLGGAALDVFDTEPLPAESPLWSMENVLISPH
                     MSGDFVGWRTTLVEVFADNFRRWRAGEPLRNVVDKQLGYVPSETLRQGLGAG"
     misc_feature    complement(17140..17142)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(18004..18006)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18230..18970
                     /locus_tag="BKN51_RS27210"
                     /old_locus_tag="BKN51_26795"
     CDS             18230..18970
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631263.1"
                     /locus_tag="BKN51_RS27210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26795"
                     /product="Asp/Glu/hydantoin racemase"
                     /protein_id="WP_101610338.1"
                     /transl_table=11
                     /translation="MDFDLLEFEGPLAQRGIGVIAPFDLALERELWRWVPMEVSLHLAR
                     TPYEPVPVSMEMAQLVSDSRHLAAATRDVLHVEPEVVAYLCTSGSFVNGVDYERSLTKA
                     ICDAGAPDAVTTSGALAEVLHQLDLHRVSVLTPYDGDLTGKLHDFLAELHVRTVSSDHL
                     GLGGGIWKVSYRTIAERILAADHADADAIFVSCTNLPTYDLIEPLESALGKPVLTANQL
                     TMWACLRRMNLPIVGPGKWLREVD"
     gene            19014..19784
                     /locus_tag="BKN51_RS27215"
                     /old_locus_tag="BKN51_26800"
     CDS             19014..19784
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033808.1"
                     /locus_tag="BKN51_RS27215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26800"
                     /product="maleate cis-trans isomerase"
                     /protein_id="WP_101610339.1"
                     /transl_table=11
                     /translation="MSISPLTPPEPPSETTTIGFIYPDHAAEDDYPLAEQLLGGDMAGI
                     KLPVEHIYGTDLHAVPELLDLGSESRLADGAALLAKHEPDAVVWACTSGSFVYGWEGAR
                     DQADRLAAVAGVPASSTSFAFVHAAQALGVRRVAVAASYPDDVARLFVEFLGAGGIEVV
                     SMGSADIDTAAEVGELSPEAVVELAVSRDHPAADALLVPDTAMRTLGEINTLEIRLRKP
                     VLTANQVTVWEGLRLTGKSPLVRTLGALFGKRGN"
     gene            19788..20480
                     /locus_tag="BKN51_RS27220"
                     /old_locus_tag="BKN51_26805"
     CDS             19788..20480
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033809.1"
                     /locus_tag="BKN51_RS27220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26805"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_101610340.1"
                     /transl_table=11
                     /translation="MSLPDIEPVSRESTAGIIARQLRDAIMTGALPPGTQLGETDLASR
                     FQVSRGPLREAMQHLVSEGLLRSERHRGLFVIDLEPGDVYDIYSARSAIERAAMLRALR
                     GDREKVATELEQAVGAMAVAADDDDPTALSWADLRFHEALIAASGSKRLVRMARTLLIE
                     TRMCLTALQGTYQRVEERVTEHTRIIEALRAGDEETALSLLEAHMEDAVQRLAPGTSLR
                     EGEAPAVP"
     gene            complement(20485..20961)
                     /locus_tag="BKN51_RS27225"
                     /old_locus_tag="BKN51_26810"
     CDS             complement(20485..20961)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033810.1"
                     /locus_tag="BKN51_RS27225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_26810"
                     /product="DUF4262 domain-containing protein"
                     /protein_id="WP_101610341.1"
                     /transl_table=11
                     /translation="MCWHCDNPGKTRDDYLTEEVRPLIRKYGWMVQTVERGAAQPGFAY
                     TVGLTDAGLPELVVTGLRERRSGQLLNYFAQQVVRSGPPDSGEVLPAALGWPALEVVPL
                     SSPSAHLLTAVLLYGADFRALQLVYEDEHGNWPWDRDFRGGTGGQPVLGARGRG"
     misc_feature    complement(21207..21217)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 17.16"
                     /tool="antismash"
ORIGIN
        1 cggggcatgg cagcaggaag cgaaccacgc gaccagccgt ccccgcagga acaccggcgt
       61 ggcgacggtg atgtcgttga tctgccccgc cgtctgccac gggtcgttgg tgagcaggac
      121 gtcgcctggc gcgagggtct ccggcgggta cgcggcgacg aaatggtgca tcccggtcgc
      181 catcgcgttg atgtggccgg gggtcccgcc gacggactgg ccgatcatct cgccgcgcga
      241 gtcgaacacc gcgcaggcga gatcgagcga ttcccgcacc acggaggaga acgcggtgtt
      301 gacgagcgcg ttctgctgct ccgcgaggat cgaatgcagc cggtttccca gcactcccac
      361 gaggatcggg tcgacgctca taccgtcacc accaggctgg cgtcttcgcc gaccacgcag
      421 tgagcgccgg gcggaacgac cacggtggac tcgcgctcct cgacgatgac cggtccctcg
      481 acacgatcac ccggcttgag ccggtaccgg tcgaacaccg ccgtgtcgac aaatccacct
      541 tcggcgggaa agtacgccgg acgactcccc ttgcgcgcgt cgccttcggc caccacaccc
      601 gcgagtttca aggtgacctc gggtaccgga ccgctggaaa cgacccgcca gttgagcacc
      661 tcgatcgcga cgtccggccc ggtccgccgg tacagcgtcc gataggtccc ggtgaacgcg
      721 tcgaccagcg actccggcca gttccccggt tcgaccggca cgcggatctc gtagccctgc
      781 ccggaatacc gcatctcggc gatcctgcga tgcgtcacct tcgcaccgtc cacaccggac
      841 ttctccagca gttccccgcc ctcggtctcc atctcggcga acagctcgtc gacctgttcc
      901 catgagagat cgaggaccgc cgagcgcgcc gagcgcacga agtcgaaggc cagcggcgcg
      961 gtcaggaatc ccgccgcgct cagcactccg gcggcgggcg gggcgaccac ctcgggcgcg
     1021 ccgagcgccc gcgccacacc gacgccgtgc accggcccgg cgccaccgaa agtgaacatc
     1081 ggcagcttcg ccggatcctt gccgcgctcg acggcgtgga cgcgggcggc gttggccatg
     1141 tcctcgttga cgctcgtgtg aataccccag gcggcctctt cgacactgac gccgagcggt
     1201 ccggcgatct tcgaacggat cgcctcgcgc gcgccctcgg cgtccaaagt cattccgcca
     1261 ccgaggaagt agccgggatc cagatagccg agcacgaggt cggcgtcggt cacggtcggt
     1321 tcggtgccgc ctcgcccgta gcagaccggg ccgggttcgg accccgccga atccgggccg
     1381 acggtcagca ggccgagtgc gtcgatgcgg gcgatcgagc cgccgccgac cccgatttcg
     1441 atcatgtcgg tgaccgggac cttgaccggc agccccgacc ccggcagcag ccggtacttc
     1501 cggtcgacct cgaactcgtg cgtcaccagc ggcgagccgc cggagatcat gcacagtttc
     1561 gccgtcgtgc cgcccatgtc gaaggccagc agatcctcga caccggccgc ggaaccgatc
     1621 gcggacgcgg ccagcgcccc accggccggg ccggattcga ggatgcggat cggatagcgc
     1681 gcggccgtgt cgacggtcgc gatcccgccg ttggacagca tgatgtgcgg cgacggccgg
     1741 accccggccg cgtgcaggcg ccgttccaga tcacgcagat agcgttcggt gaggtcctgg
     1801 acgtacacgt tcgcgaccgt ggtggacgcg cgttcgaact cgcggatctc cgggacgacc
     1861 tcgctggaca acgcgacccg cagcctcggc gcgacgtcct ggagtatctc ggcggcccgc
     1921 cgttcgtgcg cgggattcgt gaaggcgtgc aggaaacaga tcgcgaccgc gtcgatcccg
     1981 cgggcgtcga gctcgcggcc gaggcgggcg acgtactcct cgtccagtcc tgtgtggacg
     2041 gttccgtcgg cgaggatccg ctcggggacg tcgaaccgca ggtgtcgcgg gaccagcggg
     2101 tcggggagct cgatgagcag gtcgtacagt tcgtaccgat gttcgcgccg catctccagc
     2161 acgtcacgga aaccggcggt cgccagcagc gcggtccgcg atcccttgcg ttcgatcagc
     2221 gcgttcgtga ccagcgtggt gccgtgcacg aactgctcga cgtcggccgc ctccagcccc
     2281 gcgtcggcga gtgtcctcct cagaccttcc tcgacggcac gagcgggctc gtcgtgcgtc
     2341 gtcaggacct tgccgacggc gacgacaccg gtttcgtcga gcacgcagag atcggtgaac
     2401 gtgccgccga tgtccacgcc gacgcgaagc ccggtcacga agaacccttg cgataccaac
     2461 gcggagacgt gttgagcggc ggcgccatct tcgcgcggac gaccagcacg ttcggctcgt
     2521 cggactcgac gaactcgccg agcaaccggc ggaacgcgcg cccgaacccg gagacgcggt
     2581 ccgcgtgcac cccgaaggac cgggcgagac cgacgaaatc ggggctgtcc cagtcgacgc
     2641 cccggcgcgg caggcccgca cgatcctgat cgtagcggag cattccgtac ccgccgtcgt
     2701 cgacgatgat caccgtgacc ggcaactgtt cctgcgccag cgtggcgaga tcaccgcagc
     2761 cgaacaggaa tccgccgtca ccgctgacgc agatcgcgcg gccggtgccc gcggcaccgg
     2821 cgccgagcgc ggcggggaag ccgtagccga gggtgcccca gcccatcgga tacgcgagct
     2881 tgcgcggggc gcggacgcgg tggaacccgc cgatccagta cccggcgacg cacatgtccg
     2941 cgaccacgac ggcgtcctgc ggcagcactt cgtccaaagt ggacagaagg tccgcggcct
     3001 gcggctcttc ttccttgatc cgccgccgga cccgggcgga gaccttggct agcctgccga
     3061 cgagcgccgc gatacccggc cgttcctcga ctttcagcgc ctcggtgagc acccgggcgt
     3121 cgccgaccag cgtgatgtcc ggctggtagt tcttggccgc gtcgtccggg tcgacgttga
     3181 tcgcgatgag cttcttcggc tgcggcatca gccagttctg cgtcatcagc ccgtcgaagt
     3241 cggtgccgat ggcgaggacg acgtcggcct cgtcccacag cgcgccgacc tcgggcgcgt
     3301 gcaccgggtt cggggcgaga caggggtggt cgaccgacag gagcccgcga gcgccgaagg
     3361 tggtgagcac cggagcggcc agccgctcgg cgagtttgcc gatcgcctca ccggccccgg
     3421 cgcgcagcgc gccgcctccc gcccagatca gcggccgggc ggcggtggcc aacagggcct
     3481 cggcctcgga gagatccggg atctcggacg gccgggcgtg cgacctcggc ggacggcggg
     3541 cgggcgtccg ctcggacagg aagtcggtgg ggatgccgag gtagaccggc ccgctctgcg
     3601 gctggagcgc gaggcgggcc gcgcggtgca gggtggcggc gacctggtcg gcgctcgtga
     3661 cggtgaaccc ggccttggtg accggcgcga acatcgcctg ctgatccgac gtctcgtgca
     3721 gcacgccgcg gaccacgccg ggccgccgca gcgtggacgg gatgtcggtc gcgatgacga
     3781 gcatcggcgc ggccgacgcc atggcctcgc cgacggcggc gagcgtgttc gccgcgccgg
     3841 gtcccgtggt caccatggcg acgcccagtt tcccggtcgc gcgggcgtat ccgtcggccg
     3901 cgtacccggc cgtctgctcg tgccggaccc cgatgagccg gatgtccgaa tcggccagcg
     3961 cctcccataa cggcaggttg tgcaccccgg ggagaccgaa gacgacttcg gtccccagag
     4021 cggtcagcgc gtcggcgaga tgctgggctc cggtgggtgc aggcaccccg ccgatagtgc
     4081 cagatcgttc aacgatccag caaccgtgac ctcctgcccc gtgagcggca cggacggtta
     4141 gaaccatcct taccactcac gaggtcagta cagaccggcc gagtacttgc tcggctcgta
     4201 gtacgcctcg agctcggcga tgctgtcctc cggccgctcg aaggtcttcg agatgaccgc
     4261 cctcgacggc atcgcgccgg gtgtccagct ctcgggcgac cagagcttcg accgcatgaa
     4321 cgccttctgg cagtggtgga agatctcgtc gatgtcgacc accagcgcga gccgcggccg
     4381 gttgccccgc acgatcatgt cgtcgaagaa cggcgcctcc cgcaccaggc gcgcccggcc
     4441 gttgatccgc agcgtgtcgc cgcggccggg gatcaggtag atcagcccga cgtgcgggtt
     4501 cgacagcacg ttgcggaacc cgtccgcgcg gcggttgccg ggacgctccg ggatcgcgat
     4561 ccgcgtgtcg tccagtacca gtgtgaaccc ggcggggtcg cccttcggcg agacgtcgca
     4621 ggtgccgtcc gccgccgacg tcgcgatcag cacgaacggc gactccgcca gccatcgccg
     4681 gtccatctcg tggagcgcgg gccgcgcctt gttcgccgtc cgctccagcg gcggcggcag
     4741 gatctcccgc agctccgcct cgctggtgac ctcgatgaac ccgtcagaca atgttgtgct
     4801 ccctcgtcgc ggcccggtcg ccggcgaacc ggcggacgtc gagcccggtg atgtcgatgg
     4861 ccgggacccg ccccaggtag aggtcccgca cgagctcccc cacggccggg cccatctgga
     4921 acccgtgtcc cgaaaatccg gtcgcgtaga agaaccgcga tacctggacg ctttccccca
     4981 cgatctggtt gcggtcgggg gtgacctcgt acagcccggc ccagccactg cggatccccg
     5041 cttcgagcac ggcgggcacc cgcctcgcgg cgatctcggc gagcttcggc aaccagtcgc
     5101 ccggctgata ccgggtgtcg aaaccggggt cgccgtcacc gtcgcagaag gacatcgcca
     5161 ggcctagacc ctcacggtgg aagtagaagg ccgacggcat ctcgatggtc agcggcacgg
     5221 attcgggcag gcccgcgacc gggccggtga acaccacctg ccgccggaac ggccgcaccg
     5281 ggagctcgac accggcgaac tcgccgatcc gccccgacca cgcgcccgcc gcgcagacca
     5341 ccgcgtccgt ccggacgaga ccgtcgccgg tccggacacc ggtgatctcg tccccgtcgc
     5401 gttcgatccc gacgacctcg acaccggtct tcagcaccgc gccgtgcccg cgggccgccc
     5461 gcgcgtagcc ctggaccgcg gagtccggcg tggccttggc gtcgtccggc gaccacagcg
     5521 ccgcgatcac gccttcggtg tcgatcatcg gggagaaccg tcgcgcttcg gccggctcga
     5581 cgagacggct tcggacgccg taggagttct gcagttcggc gcagcgttcg aactcgggca
     5641 gatccgcggg atcagtgacc aggtacaggt agccgtcgcg gcggaagtcg atctcggcgc
     5701 cgtacgtctc ggcgaacgag gcgtactcgg ccagcccgcg cagcccgatc tcgatgttga
     5761 cgtgcgtggt gaacgacgac cggatcccgc ccgccgcctt ccccgtcgag cccgcgccca
     5821 ggctgtcgcg ttcgaggagc agcaccgaga ccccggccgc ggcgagccgg tacgcgcagc
     5881 tgaccccgat gatgccgccg ccgatcacga cgacgtcggt acgttcagga agtgactcca
     5941 tccgtggcct cgatccgttc gtcctcgggc ggcggtcccg gcggcgtgcc gtcaccgaac
     6001 gggcgcccgc ccagctgctc ccggtgatgc ggggtcgccc agccggacag gtccggtccc
     6061 atcgggacga tccgcgtcgg gttcacctgc tcgtgcaccc cgtagtagtg ccgcttgatg
     6121 tggtcgaaat cgacggtgtc accgaagccc ggtgtttgga agaggtcgcg ggcataggcc
     6181 cacagcaccg gcagttcggt cagtttgtcc cggttgcact tgaaatgccc gtgatagacc
     6241 ggatcgaagc ggacgagcgt ggtgaacaac cggatgtccg cttcggtgat cgtgtcgccg
     6301 acgaggtaac gctggttttc gagccgctcg gaaagcgcgt ccagcatggc gaagagccgg
     6361 gtgtacgcgt cctcgtacgc acgctgcctg gtcgcgaaac cggcctggta gacggcggcg
     6421 ttgacgtcgg cgaagacccc tacgttgacg tcgtcgatct cgtcgcgcag ccgctcggga
     6481 tagaggtcgg gcgcgccggg ccggtggaga ctggtccatt cggtggaaag atcgagcgtg
     6541 atccgcggat agtcgttgct caccagccgc ctgctcggaa tgtccacaat ggccggaacg
     6601 ctgatcccgc ccatgtagtg cggatcggcc gcgtgatagg cctcggccag gtacttgatg
     6661 cccagcaccg ggtcccggtc atcgggatcg agggtgaacc gccagctctt gtcgtcctgg
     6721 atcgggtcgg cgacggcgac gctcagcgcg gactcgaggc cgagcagccg ccggacgacc
     6781 agtccccggc tcgcccaggg acaggcccgg ctgaccacca gccggtacct ccccgcctcc
     6841 accggccagc cgtcgcggcc gtccgcggtg actcgcgcgt cgaaatggtt ggcggaccga
     6901 cggaactcac ccgtcttcgg atcggtcggg atcgtcatgt gagccaccct aaagcgtgag
     6961 agggtggttt cggtgtgcgt agactctggc acccggcgtg ctcgcacgcc gccgcgcgga
     7021 aggtggtccc gacgatgccg ttcatgcccg tgaccgactc gatgttcctt ctcgtggaaa
     7081 cgcgcgaaca tccgatgcac gtcggcggac ttcagctgtt caagaaaccc gaggacgccg
     7141 ggcccgacta tctgcgtgac atccgccgga aactgctcga ttccgacaac atgcgctcgg
     7201 tgttccggcg gcgtcccgcc cggccggtca acaccgccgg gcacatcgcc tgggcgacgg
     7261 acgtcgacct cgaactcgat taccacttcc ggcattcggc actgccccag cccggccgga
     7321 tccgcgagct gctggaactg accgggcgct ggcacagcac cctgctcgac cggcaccggc
     7381 cgctgtggga gatccacctg gtcgagggcc tgcaggacgg ccggttcgcg atctacagca
     7441 agatccacca cgcgctgatg gacggcgttt cggcgctgag gcatctgcag ggcacgctgt
     7501 cggacgaccc gaacgacctc gactgcccgc cgccgtgggg ccgccgggcc aaaccggacg
     7561 acgggcgcaa cggcaaggcg tcaccctcgg tgctccagac catggggaag acgttcaacc
     7621 agctcgccgg catcgcgccc gccgcgatga aggtggcgcg ggaggcgttc caggagcaca
     7681 cgctcacgct gccggcgcag gcgccgaaga cgatgctgaa cgtcccgatc ggcggggcac
     7741 ggcgattcgc cgcgcagtcg tggtcgctgg accgcgtgcg caaggtcgcg accgccgccg
     7801 gggtgtcacg caacgacgtc gtcctcgcga tgtgctcggg cgcgctgcgg gactacctga
     7861 tggaacagaa cgcattgccc gacgccccgc tgaccgcgat ggtcccggtt tccttgcggc
     7921 gcaaggacag tggggacgcg gcggggaaca acatcggcgc gctgctgtgc aacctcgcca
     7981 ccgacctggc cgaccccgcc gcgcggctca cggcgatcaa cgcgtccatg cgcaacggga
     8041 agaagctgtt ctcggagctg accccgctgc agacgctcct gctgtccggg atcaacgtcg
     8101 cccagctcgg cgtgtccccg atccccggca tcgtgaacaa cacgaaaccg ccgttcaacc
     8161 tggtgatctc caatgtgccg gggccgcgca agcagatgta ctggaacggc gcgtcgctcg
     8221 acggcatcta cccggcgtcg gtgctgctcg acgggcaggc gctgaacatc acgctgacca
     8281 gcaacgggga caacctggac ttcggcatca ccggttgccg tcgcagcgtc ccgcatctgc
     8341 agcgcatcct gacgcacctg gacaccgcgc tcgcggaact cgaacacgct gtatctatcg
     8401 ggcgcagctg actcccgcgt ttagtcctct ggttgcggtt gtccaccgca accagaggac
     8461 taaacgcgcc ggcgctagct gccgtcggag acgtagatgg cgcccggtgt gatcgtgtag
     8521 agctggccgt cgggtccggc ggtggcgtca cgggtgcggc cgaggttggt ccagagcttg
     8581 ccgccgttgc cgttcaggtc gagcttgtac gtgccgccct tgagggaggc catgtacagc
     8641 gagcccttgt aggccgccag cccgctcggc gtcgccgaag ccgtcggcca ggccttgacc
     8701 gggttggtca tccccgccgt gttgcacggt ccctcgcagg tcggccagcc gtagttcttc
     8761 ccggggtcga tcttgttcag ctcgtcgagc ttgttgttgc cgatgtcgga gatgtacagc
     8821 tgcccgttcg cccaggtcag gccctggacg ttgcggtggc cgtaggagta gacgcggctg
     8881 ttgaacgggt taccgggtgc ggcggcgccg tcggtggtga cgcgaaggac cttgccgccg
     8941 agcgagttct tgttctgcgc gttggcgccg ttctggccgt cgccggtacc cgcgtagagg
     9001 taaccgtcgg ggccgaacct gatccgcccg ccgtggtgat actgcgagcc acgcgggata
     9061 ccggtgacga tcggtgtcgg cgcctggccc agcttcagct tggcgatgcg gttgtcggaa
     9121 ctggtcgtgt agtagatgaa gaccgtctcg tccgtggcgt acttcggcga gaccgcgata
     9181 ccgagcaggc ctgcctccgc ggtgacgctc accccgggga tggtctggac cgtggtgacc
     9241 ttgcccgcct tgtcgatccg gctgatcgtc ttggcgtcct tctgcgtgaa aagacccgtg
     9301 ccgtcgggca ggaagtcgat cgaccaggcc tggttgagac caccggcgag ctgtctgatc
     9361 gcctggatgg acggcacttc ggcggcggcc gccgggaccg ccgcgatcga cacggccgtc
     9421 gcggccgcga acgtggcggc gagagtacga cgtaaggaca tgggacgcct ccttcagcta
     9481 cacccctgga gctcggatgg cggcggtcgg cgggtggccg gggttcaccc gtcgagttgg
     9541 atacaaacac accatgggac gaaacggaca ccactggacg gggtatcgga agcccttccc
     9601 gttaaccgtt gtgtgcgccg agcgtgacga tcggggcggc tcgatcggcc ataggtagga
     9661 aactttacaa aacggcttcg gaacttggtc cttacgtctg gtcagaatcg gcggcccgct
     9721 tctagggtgg cggggctcgg cccggttcgt tcccatgtgg acgttccggg gatcaaggtc
     9781 agcgatccga ggagtgagaa aatgatcgaa gccatcgagg tatggaccac acccgacttc
     9841 gtcgagtacg aaactcccat ggaggtcacc gcttacgcgg cccgcatgga ggactgattt
     9901 cccacccggt ggtgggggcc gtcccccacc accgtgccgc cgtcccgatc agcgagccgt
     9961 tggaggcagc atcgtgtctc ttcctctttc cgccgagccg atgtcgtcgg cggaattcat
    10021 cgcggccttg cgcgggcttt cccaccgcta ctggggcacg catccgttcc accaccggat
    10081 gcacggcggt gaactgtccg agcacgaact gaagatctgg gccgcgaacc gctggtacta
    10141 ccaatgcgtg ctcccgcaga aggacgcggc gatcatcagc aattgcccct tgcccgagat
    10201 ccgccgtgaa tggctcgacc gcatcgtcta ccacgacggg acgaaagccg gggacggcgg
    10261 aaccgagcga tggctccgtt tgtgcaccgc ggtcggactc gaccgcgaag aggttctcga
    10321 tcagcggcac gtcgcccccg gcgtccggtt cgccgtcgac gcctacgtga atttcgcccg
    10381 cacgaaaccg tggctcgaag cggtcgcttc ggggctgacc gaaatgttcg cggggcacct
    10441 catgcagcga cgcgtcgccg acatgctggc gaactactcg tggatcgcgc gggaagacct
    10501 cgcctacttc accaatcgca tcgacaaggt ctcgggcgag ggcaaaggaa cactcgacat
    10561 cgtcgtgcgg cacgccgtca cccgcgaaca gcaggagaag gcgatcgccg cgctgtcgtt
    10621 caagaccgac gtgctctggt ccatgctcga cgccatcgag cgcgccgcgg ccaaggagta
    10681 gcgatgacca ccatcaccac cggttccgtg ccgcggctgc ggcgcggcgt ccggctgagt
    10741 tatgaccgga caagggaaac tcacgtcctc ctgttccccg aaggcgtgct cgtcccgaat
    10801 ccgaccgccg ccgccgtgct cggactctgc gacggcgcgg cggacgtcgc cgcgatcgcg
    10861 gccgcgctgc gcgagcgcta taccggtgtg cgtgagcaag agatcctgga cgtcctgacc
    10921 aggctgggag atcggcggat cgtcgaatgg acctgaacac ctccaccgcg gcgccgccct
    10981 tgggcatgct cgccgagctg acccatcgct gcccgctgca ctgcccgtac tgctcgaacc
    11041 cggtcgaaat gatcgcccgc gacggcgaac tgtccacaga ggaatggctt tccgtgctct
    11101 cacaggcgcg ggaactcggc gtgctccagg tgcacatgtc cggcggcgaa ccgctcgcca
    11161 ggccggacct gcccatcctg gtcgagcacg ccacgaaact cggctgctac gtcaacctgg
    11221 tgacgtccgg actcgggctg accgagccca gattggacga tctcgtcgaa cgcggcatcg
    11281 cgcacatcca gttgtccgtc cagggcgcga ccgccgaacg cgcggaccgg ctcgcgggtg
    11341 cccgggccca cgaccggaaa ctggtcgtcg ccgggctgat caagaaggcc ggtctgccgc
    11401 tttcggtgaa cgtcgtcctg caccggcaga accacgacca gctcgccggg atcatcgacc
    11461 tggccgagca gatgggcgcg gaccggctcg aactggccaa cacgcagtac tacggctggg
    11521 cgttgcggaa ccgcgacgcc ctgatgccga ccaggcggca actcgacgag gccgagccga
    11581 tcgtgcgcgc ggccaccgaa cggctgcgcg gcagcatgga gatcatctac gtcgtcgccg
    11641 actactacga gcagtacccg aagccgtgca tgtacggctg gggcgcgcgg cagctgaccg
    11701 tggcgcccga cgggaacgtg ctgccgtgtc ccgcgtcgac cgcgatcgag accctgacgt
    11761 tcgacaacgt gcgggacaag ccgctggcgt ggatctggta cgaatccggc tccttcaacg
    11821 cttatcgcgg cgaggactgg atgccggaca cctgtggcac ctgcgacagg cgctcgatcg
    11881 acttcggcgg ctgccggtgt caagcgttcc agctcaccgg cgacgcggcg gcgacggatc
    11941 cggtgtgctc gcgttcaccg cgtcgcgacg tcgtcgatct catcctcgcc acacccccga
    12001 aaacggacga gctcgtgatg cgggggccgc aatgagggtg atcttgctcg gcaccgcggc
    12061 gggaggtggc ttcccacaat ggaactgcgc ctgcgcactg tgcacttcgg acgcgccgcc
    12121 ccggacccag gactgtgtcg cggtgagcgc ggacggtgaa agttggtatc tgctcaacgc
    12181 gtctccggac atccgcgcgc agattctcgc cacgccgccg ctccgcgccg gtccagggcc
    12241 gagggagatc ccgctgcgcg gcgtgctgct caccgatgcc gagctcgatc attcgctcgg
    12301 cctgctcctg ctgcgggaag ccggcgggct gccggtgtgg gcaccggaag cggtactcgg
    12361 cgcgctgtcg gagcagttcc ccgcgaggtc gatcatcgac ggctacggcg gctgggactg
    12421 gctgtcgaac tcggagatcg ccatcgacgg actccgcgtg agcgcgcttc ccgtcagtga
    12481 caagaggccg aagtacgcgc gttcgtccac tgaggacggc ccgtgggtgg tggcgtaccg
    12541 gatcgaagac gtccagaccg gcggggtgtt cgtgtacgcg ccttgcctga agagctggcc
    12601 ggacgggttc gacgccttca ccgagggcgc gagcctggtt ctcctggacg ggacctttta
    12661 cgcgccggac gagatgtcgg gcgccacggc tgccgaggtc ggcgacggtg cccagctggc
    12721 gatggggcat ctgccgatca ccggcagtct cgcgaagctc cggcccggtc cccggtgggc
    12781 gtacacccat ctgaacaaca cgaaccccgt cgtcgacccg tcttcgccgg agcacgccgc
    12841 cgtcctggac ggcggcgcct cgcttccctt ggacggtact gagttcgagc tctaggcgac
    12901 gccctcggga ctggcgcccg aaacgggaac ggcgtcggcg gtgaggcggt cgatctccgc
    12961 gagctcgtcc gcggtcaggt cgacgtcggc cgcggcgaga ctggcttcga tgttggccgc
    13021 cttgcgcgcg ccgacgatcg cgacgtgcac gcccggttgg gcgagcgtcc acgcgatcgc
    13081 gagctggctg accgagatcc ccttgtccgc ggcgaattcc tcgagcttgt cgacgatggc
    13141 gaggttgcgc cggaaggtct ccccggtgaa cgccgacgag cgcgagcgcc agtcggtctt
    13201 ctcgaacgtc gtctccggcg tgaaggatcc ggtcagcagg ccgctgccca gcgggctgta
    13261 cacgagcacg ccgatgtcgt tctctcgcgc gtacggcaga ggatcggtct cgatgtcgcg
    13321 gcggaacagg tggtacggag gctggagggt ttcgatcgga cgggtcttgt cgaagtcggc
    13381 cagaccggcg gcgtcgtagt tcgagacacc gatgtgccgg atcttccccg cgtcgacgaa
    13441 ctcctgcagg atccccgcgg tctcctcggc gggcgcgtcg gaatcgggcc agtggatctg
    13501 gtagagatcg atgtggtcga cgtcgaggaa gcggagactg tcctcgattc cttgcgtcag
    13561 ccactcgcgc cgggagtcgc gcggacggtc ggatcgcggc ttgatgccgc ctttcgtggc
    13621 gatgacgagg ctgtcgcggt cgcgcttgag ttcctcgcgc aacgccttcc cgagcatggc
    13681 ctcggacttc ccgaaaccgt aggcctgagc ggtgtcgaag aaatcgaccc cgagttcgcg
    13741 ggcgtggtgg atcgcggcga tcgccgcgtc ctcgtcgaac gatccccagt ccccgccgag
    13801 ctgccaggtg ccgaaggcga tcctcgaaac ctcgaggccg ctcctgccca atgtcgtcgt
    13861 acgcatacct ccagcagagc acagacatcg gaccatcgca ccggatctcc cggccaacga
    13921 aacccccaaa taactgtttg acggttggcg tcccggcagt cgatactcac cctcatgtcc
    13981 gagtccccca gcctcgacgg gctgcgcgtg ctggcccatc ccgtgcggct gcgcattctg
    14041 tcgcttttga ccggtgtcgc gatgagtgcg gccgaagccg cgcgcgaact cggtgagaca
    14101 caagcaaata tcagctatca cctgcggcgg ctgcacgagg ccggactgct cgacgtcgcc
    14161 gaggaggtcc ggatccgggg cgggctggcg aaacgctacc ggcacgatcc ggagtccggc
    14221 ggtcggttcg cgtcgacgaa tccgcaggag gaccagatcc tcatcgcggc gatggccgaa
    14281 gaactcaagc ggcgcggcga attccgcgtc gccggacaac ggggttcgac gaccgacgcg
    14341 gagatctggg tcgaccgcga gacctgggaa aaggcggtcg aacacgctca cgagctgagc
    14401 aagctcctcc actcggccgc gcgaccgcct cgtacccggg gcacgatccc ggtcagcgcg
    14461 acggtttcgc tgttcgaaat gacgcgatcg tgacgtcact gcgcgagccc ttgcgccatc
    14521 acaacttccg ctggctgatc ggcggccgca cgttcgggga gttcggcaac gccgtcgccc
    14581 cgctcgcgct ggcgttcgcg gtgatcgacc tgaccggttc ggccgtcgac atcggcatcg
    14641 tcgtgggcgc gcggtcggtg gccagcgtcg tgttgctgct gttcggcggg gtattggccg
    14701 acaggttgcc gcgatcggtg atcctgcagg gcaccgaact cgcggccacg ctgacccagg
    14761 cgaccatcgc cgcgagtgtc ctttgtggat tcgcgtcgat cccgctgctg gtcggactga
    14821 gcgtggtcaa cggcgcggtg accgcgatct ccgcgccggc ctcggcgtcg ctcaccccgc
    14881 tgaccgtgcc cgccaccctg ctggcacagg ccaacgcgct gggcaggctg ctttcgaact
    14941 ccggccggat cgccggtgcc gggctcggcg gcgtcctggt caccgccgtc ggccccggct
    15001 gggcgctcgg cgggaacgcg ctgctgttcc tgggctccgc cctgtcctat cggcggatcc
    15061 gcctcagccg ccgggaacgg gtccccggca gccgtccgct ggcggaactc gccgaaggct
    15121 ggcgagagtt ccggtcacgg acctgggtgt gggtcgtggt cgtgcagttc atggtggtga
    15181 acgccgtcat cgccggcggg atcgcggtgc tcggccccct ggtcgccgac ggcaccttcg
    15241 ggcgctccgg ctggggattc gccatcgcgg cgcagacgat cggctcgctc gtcggcggga
    15301 tcctcgtggc ccgatggcag ccgcggcgcg cgctgttcgt cggtgtcgcg gtgatccttt
    15361 tcgaagcgcc gccgttgatc cttctcggtc aggcaccgtg gttgccgctg ttgctggcgg
    15421 ccatgttcgt ctccggcatg gcgatcgagc agttcgtggt ggcctgggac gtctcgctgc
    15481 aggagaacgt gcccgaggac aaactcgcgc gcgtctactc ctacgacatg ctcggttcct
    15541 tcatcgcctt gccactcggc cagatggcgg cgggaccggc ggcgctgcac ttcggggtca
    15601 gcacgaccct gatcgcctgc gccgcgctgg tcgtggccgc cacctgcctc gcgctgtgca
    15661 gtggccaggt gcgcggcctg gtgcggaaga cccacgccgc gcaaccctga acctcaccgg
    15721 cgatagcaaa ggtcccttgc tctctttccg ctggtcacgg ccagggacgg acctcttcga
    15781 ggagtttcgc gaccgcgagc accaggtcgt cggagtgccg cgggccgatg atctgcaggc
    15841 cgaccgggag accacgagag gtgcgaccgg ccggcacgct gatggcgggc tgctgggtca
    15901 tgttgaacgg gtaggtgaac ggcgtccagt ccggccagcc gctcagtccg ctgcccggcg
    15961 gcacctcgtg cccggcctcg aaggcggcga tcgggagggt cggcgtgatg agcacgtcgt
    16021 accgcgtgtg gaactcgccc atcaggatgc ccagcgcggc ccgctcggcg ttggcgccga
    16081 ggtagtcgct cgccgagaag gtcttgccga gttcccacac cttccgcagc cccggatcga
    16141 ccatcgtgtc cgaaccggcg gggaaggtgt ccagccactt ggccgcgccc gtcgaccaca
    16201 ggatgtcgaa ggcgggcttg gggtcgctga agccgggatc ggtctcctcg atgtgcaggc
    16261 ccgcgtcgct cagcgactga accgccgact tgacgatcgc cgcgacctcc ggatcgacgt
    16321 cgacatagcc gaacgtcggc gagtaggcgg cgttcagccc gcgcacgtcc cggcgcaccg
    16381 cttcgcggaa ggtcgagacg ggcggggcga gcgcggccgg atcgcggtga tcgggcaagg
    16441 cgaggacgtc gaggagcagc gcggtgtcgt ccaccgaccg cgccatcgga cccgcgtgcg
    16501 acagcgggcc gaacgggctc gccgggaaca gcggaatccg gccgtgtgtc ggcttgaggc
    16561 cgacgattcc gcagaacgaa gccggaatcc ggatcgagcc accgccgtcg gtgccgacgg
    16621 agagttcgcc catcccggcc gcgacggccg cggcactccc accgctggac ccacccgccg
    16681 tcgtcgacgg atcgtgcggg ttgcgggtga tcccggtcag cgtgttgtcg gtgacaccct
    16741 tccaagcgag ttccggcgtc gtggtctttc ccagcagcac caagccgttt tcccgcagtc
    16801 gcgcggtgac cgggctgtcg acgtcccacg gctggtccgg atcgatgcac cgcgaaccgc
    16861 gcaacgtcgg ccagccctgc gtcaggaaca tgtccttgat cgaggccggg acaccgtcga
    16921 gccagccgat cgggttaccg tcccgccagc ggatctcgga ggctttcgcc tgttcgagcg
    16981 cgccatcggc gtcgacgagg cagtaggcgt tggtctcgcc gtcgcgttct tcgatgacgc
    17041 gcaacgcgtt ctgggtggcc tcgaccggtg aaagctctcc ggtggcataa gcggcgacga
    17101 gctcgctcgc ggtcaacttg gtgtcgttca tccggcccct aacccttgac gaagcgtctc
    17161 cgacggcacg tatccgagct gcttgtccac gacattgcgc agtggctccc ccgcgcgcca
    17221 gcgacggaag ttgtccgcga acacctctac cagagtagtg cgccagccga cgaagtcgcc
    17281 cgacatatgc ggcgagatca gcacgttctc catactccac aaaggacttt cagcgggcag
    17341 cggctcggtg tcgaagacgt cgagagccgc accgccgagc gggccgtccc gcagcgcgcc
    17401 gaccaggtcg gaggtgacga ccagctcccc gcggccgacg ttgacgaacc gcgcgccggg
    17461 cttcatcgcg gcgaaggcct cggcgtcgaa catgcccttc gtctgctcgg tcagcggggc
    17521 gaccgcgacg acgtagtccg cctcggggag atgacgggcc aggtccgagg aggagaacac
    17581 gtccccgaaa tcgggatcgt cttcacgggg gcgacggccg acgccggcca ccgacatccc
    17641 ggccgcccgc agcgaccgcg cgatcgaccg gccgatcggc ccggtgccga ccaccaggac
    17701 acggcgtccg gagatccgct cactctcacg gtgcttccac tgcttccgcc gctgcaggtc
    17761 ccacgaccgg acgaaatcct tggcgaacgc gaggacgacc ccgaggacgt actcggctat
    17821 cgccccgtcg aacaccccgc gcgagttggt gagcacgacg tcgctcgcct gcagcccggg
    17881 gaagagcacc gggtcgacac ccgcgctggc gatgtgcagc cagcgcagcc cgtcggccgc
    17941 atgccaggca ccgggcacgg cggtcgaaag gaagtcgtag acgaagagcg cgtcggctcc
    18001 ggataacgca tcggccagcc cggcctcgtc ggtgtaacga accaccgctt cggcttcgat
    18061 agcgcgcatg tccggtgggc gtgcgtctcc gcagagcacc gccagcacag gggtctccga
    18121 gggtttcacg ttgacaccgt aaaagtggct cgtatgattg tcaacaatcc gaggaacgac
    18181 ccccggagca ccggacctgt ggcagcagaa gttctccgga ggctgaaact tggatttcga
    18241 cttgttggag ttcgaaggcc cgttggcgca gcgcggcatc ggcgtgatcg ctcccttcga
    18301 cctcgccctt gaacgcgagc tgtggcgctg ggtgcccatg gaggtctccc tccatctggc
    18361 gcggacgccg tacgaacccg tgcccgtcag catggagatg gcccagctcg tcagcgacag
    18421 caggcatctc gccgccgcca cgagagacgt gctccacgtg gagcccgaag tcgtcgccta
    18481 tctgtgcacc tccggaagtt tcgtcaacgg tgtggactac gaacgctcct tgaccaaggc
    18541 catctgcgac gcgggcgcgc cggacgccgt caccacctcc ggggcgctgg ccgaggtcct
    18601 gcaccagctc gacctccacc gggtctcggt gctgacgccc tacgacggcg acctgaccgg
    18661 gaagctgcac gacttcctgg ccgaactcca cgtgcgcacc gtctcgagcg accacctcgg
    18721 cctgggcggc ggcatctgga aggtcagtta ccggaccatc gccgagcgca tcctcgccgc
    18781 cgaccacgcc gacgcggacg ccatcttcgt cagttgcacc aacctcccca cctacgatct
    18841 gatcgagccg ctcgaaagcg cgctcggcaa acccgtcctc accgcgaacc agctcacgat
    18901 gtgggcctgc ctccggcgga tgaacctgcc gatcgtcggc cccggcaagt ggctccgcga
    18961 ggtcgattga cctcttcccc tacgattgtc gacaatctgc ctccggaggt cccgtgtcca
    19021 tctcgccgct caccccacct gagccgccgt ccgagacgac cacgatcgga ttcatctacc
    19081 ccgatcacgc ggccgaggac gactacccac tcgcggaaca gctcctcggc ggggacatgg
    19141 ccgggatcaa gttgccggtc gagcacatct acgggaccga tctgcacgcc gtacccgagc
    19201 tgctggacct cggcagcgag agccggctcg ccgacggtgc cgcgctgctg gccaaacacg
    19261 aaccggacgc ggtggtgtgg gcatgcacca gcggcagctt cgtctacggc tgggaaggcg
    19321 cccgcgacca ggccgaccgg ctggccgccg tcgccggcgt cccggcgtcg agcacctcct
    19381 tcgccttcgt ccacgccgcc caggccctcg gcgtccggcg ggtcgccgtc gccgccagct
    19441 atccggacga cgtcgcccgg ctgttcgtcg agttcctcgg cgccggcggg atcgaagtgg
    19501 tctcgatggg cagcgccgac atcgacaccg ccgccgaggt cggggaactc agcccggaag
    19561 ccgtcgtcga actcgcggtg agccgcgacc atccggccgc tgacgcactg ctggtccccg
    19621 acaccgccat gcggacgctc ggcgagatca acacactcga gatcaggctc cgcaagccgg
    19681 tgctgaccgc caaccaggtc accgtctggg agggcctgcg gctcaccggg aagtccccgc
    19741 tcgtccgcac actgggcgcg ctgttcggca agagaggcaa ctgaaccatg tccttgccgg
    19801 atatcgagcc ggtcagccgg gaatcgaccg ccgggatcat cgcgcgccag ctgcgggacg
    19861 cgatcatgac cggcgccctc cctcccggca cccagctcgg tgaaaccgac ctggcctccc
    19921 ggttccaagt ctcgcggggg ccgctgcgag aggcgatgca gcatctcgtc tccgaggggc
    19981 tcctgcgcag cgagcgccac cgcggcctgt tcgtgatcga cctcgaaccc ggcgacgtct
    20041 acgacatcta ctcggcacgc tcggccatcg agcgcgccgc gatgctgcga gccctgcgcg
    20101 gtgaccggga gaaggtcgcc accgaactcg aacaggccgt gggcgccatg gccgtcgccg
    20161 ccgacgacga cgatccgacc gcgctctcct gggctgacct ccgtttccac gaggcgctga
    20221 tcgccgcttc cggcagcaag cggctcgtcc gtatggcccg gacactgctg atcgagaccc
    20281 ggatgtgcct caccgcactg caggggacct atcagcgagt cgaagagcgg gtcaccgagc
    20341 acacgcggat catcgaggct ctgcgcgcgg gcgacgaaga gaccgcgctt tcgctgctgg
    20401 aagcccacat ggaggacgcg gtgcaacggc tggccccggg gacaagcctg cgagagggcg
    20461 aagctcccgc ggtgccttag gaattcagcc acgaccccgc gcccccagca ccggctgccc
    20521 gcccgtcccg ccgcgaaaat ccctgtccca cggccaattg ccgtgctcgt cctcgtaaac
    20581 cagttgtagg gcacggaagt cggctccgta caagaggacg gcggtgagca ggtgcgccga
    20641 cggcgagctc agcggaacga cctcgagcgc gggccatccc agcgccgcgg gcagcacctc
    20701 accggaatcc ggcggccccg accggaccac ctgctgggcg aaatagttca gcagctgccc
    20761 cgatcttcgc tcccgcaagc cggtgacgac gagctccggc agcccggcgt cggtgagccc
    20821 gaccgtatac gcgaagccgg gttgagcggc tccccgctcg acggtctgca ccatccagcc
    20881 gtacttccgg atcagcgggc ggacctcctc ggtgaggtag tcgtcgcgag tcttcccggg
    20941 gttgtcgcaa tgccagcaca tcggcactcc tccagtcgtc gaatccgatg atcgacaccg
    21001 tgcaccgggg caccgacaaa aactcgcgac tcgggtgagt gcccgtgcga tgcggagacc
    21061 tttccgtctt ggctttcctt tgcgaggcag ggaacttcgc gaattttggc gttctggccg
    21121 acttgaattt cccaggcaaa ggtgtcgcgt tcgagcgcgg tgcccgtcac cggccccacc
    21181 cccgcccgac ggccactgct cccaatgtca cattggagac gctgagcgtc tccaatgtgg
    21241 cattgggggc atcggtcccg cagcgtggag caacgtctcg accgacctga gccccgggct
    21301 gccatcacga caccttgcct cccgataagt acgtgaaggc ccccttcact gcgcctagcg
    21361 caaggaaggg ggccttcacg tacttcacat cgcgtcgctc aggcgagcga atcaccccgt
    21421 gatgtcatga acggaccgtt catgacatca cggacttgac acgcctctat gcggatggtt
    21481 caagatagag cggcgaccac cgcggacccg agttcggcgg tggtggactt accgccgagg
    21541 tcaggggttt gcacggtccc ctcctcgaga accttctcca ccgcagcgtg aacgtcttgt
    21601 gccgcagcgg tttccccgag atggtcgagc agcatcgcac ccgccaggat ctgcgccacc
    21661 ggattcgcga tgccctgtcc ggcgatgtcg ggagcgctgc cgtgcaccgc ttcgaacatg
    21721 gaagggaact cgccggtggg attgatgttg cccgaaggcg ccattccgag cccgcccgtc
    21781 acggccgccg ccaggtcgct caggatgtcg ccgaagagat tggaagcgac cacgacgtcg
    21841 agccggtccg gcgcctggac catccgcgcg gcgagcgcgt cgacatggca ctgttcggct
    21901 cgcacgtccg gatagtccga agcgatttcg aagaagatct cgtcccagaa cggcatcgag
    21961 tgaatgagcc cgttggattt cgtggccgag caaacccggc ccgtccgcgt cttcgccagc
    22021 tcgaaggcgt agcgg
//
