LOCUS       NZ_CP017780            10813 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Amycolatopsis sp. BJA-103 chromosome, complete genome.
ACCESSION   NZ_CP017780
VERSION     NZ_CP017780.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. BJA-103
  ORGANISM  Amycolatopsis sp. BJA-103
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9488490)
  AUTHORS   Ke,X. and Jia,L.
  TITLE     Isolation and identification of a potent feather degrading rare
            actinomycete Amycolatosis sp. BJA-103 isolated from the rhizomes of
            Valeriana jatamansi Jones with abundant antibiotic biosynthetic
            potential
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9488490)
  AUTHORS   Ke,X. and Jia,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-OCT-2016) College of Life Sciences, Northwest A&F
            Unversity, No.22 Xinong Road, YangLing, Shaanxi 712100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: AUG-2016
            Assembly Method                   :: SMRT v. 2.3.0
            Assembly Name :: version 2.3.0 of the PacBio Single Molecule Real
            Time
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 03:58:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,631
            CDSs (total)                      :: 8,562
            Genes (coding)                    :: 8,496
            CDSs (with protein)               :: 8,496
            Genes (RNA)                       :: 69
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 31 of 66
            Pseudo Genes (incomplete)         :: 47 of 66
            Pseudo Genes (internal stop)      :: 2 of 66
            Pseudo Genes (multiple problems)  :: 13 of 66
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:43:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1255504
            Orig. end                         :: 1266317
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP017780.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from B415, College of Life
            Sciences, Northwest A&F Unversity.
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10813
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10813
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10813
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5813](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5813)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            108..1181
                     /gene="hemE"
                     /locus_tag="BKN51_RS05855"
                     /old_locus_tag="BKN51_05775"
     CDS             108..1181
                     /EC_number="4.1.1.37"
                     /GO_function="GO:0004853 - uroporphyrinogen decarboxylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005156993.1"
                     /locus_tag="BKN51_RS05855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_05775"
                     /product="uroporphyrinogen decarboxylase"
                     /protein_id="WP_101606644.1"
                     /transl_table=11
                     /translation="MSPSAASPAQTVPAARRALPGAPFLAAARGERPARTPVWFMRQAG
                     RSLPEYRALREGTSMFDACFDPEMLAEITLQPIRRHGVDAAILFSDIVVPLKAAGLDID
                     IVAGTGPVVAEPIRDAAGVRALPVLDPEQVERVADGVRLLVGSLGETPLIGFAGAPFTL
                     ASYLIEGGPSRNHEHTKALMHSEPELWHELAGRLADMAITFLSAQLDAGADAIQLFDSW
                     AGALSERDYREFVLPHSAKVLSAVAAYGVPRIHFGVGTGELLVAMRDAGADVVGVDWRL
                     PLDEAVRRLGGGVVQGNLDPALLHASWPVLEAEVRRIHAEGRAADGHIFNLGHGVLPGV
                     DPDVLTRVVGLVHELQP"
     gene            1187..2566
                     /gene="hemG"
                     /locus_tag="BKN51_RS05860"
                     /old_locus_tag="BKN51_05780"
     CDS             1187..2566
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332996.1"
                     /locus_tag="BKN51_RS05860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_05780"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_101613065.1"
                     /transl_table=11
                     /translation="MKTAAVVGGGISGLTAAYRLRTLLGEEARIVVFEATESLGGKLRT
                     IELAGERYDVGAEAFLARRPEALALVREVGLGESLVHPTKARAKIHAGGSVLGLPPGTV
                     MGVPASADAVAGVLSEKGRALVEAESSLAPVELPAGDVPLGPLLRERFGDELVDRLVDP
                     LLGGVYAGGADGLGLRATMPGLASAVDRGARSLTEGAASLMPASPSTAPVFGTLLGGLG
                     TLIRRLAELSRAEIRTGTTVTAIERTATGWKVDDLDADSVLLAVPAPSARRLLDGVVGV
                     ASSAFAEVELASMAVIALALPPGTELPESSGVLIGAGEQDAAGKPFAAKAFTFSTRKWA
                     QYGEGPVLVRGSVGRFGEPGALHADDDELVRVVRDDLARLTGVTAAPIETLVTRWGGGL
                     PQYGTGHLELVERVERAVAEVPGLAVAGATLHGVGLPACIATADAAARRIAGITPTHEG
                     S"
     gene            2592..3284
                     /gene="hemQ"
                     /locus_tag="BKN51_RS05865"
                     /old_locus_tag="BKN51_05785"
     CDS             2592..3284
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983668.1"
                     /locus_tag="BKN51_RS05865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_05785"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_101606645.1"
                     /transl_table=11
                     /translation="MARLNYNELNDTIRYTAWSVFRAEQGKLGDDRAQATAETTEYLDA
                     LEAKGVVVRGLYDLSGLRADADYMVWWHAEEIEQVQAAYSGFRHTPLGRASVPVWSQVA
                     LHRPAEFNKSHIPAFLAGEEARKFICVYPFVRSYEWYLLPDDERRKMLADHGKEARDYP
                     DVRANTVASFALGDYEWILAFEADELHRIVDLMRHLRGTEARLHVREEIPFYTGTKVEP
                     AELITLLP"
     misc_feature    2634..2649
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.76"
                     /tool="antismash"
     gene            3296..4642
                     /locus_tag="BKN51_RS05870"
                     /old_locus_tag="BKN51_05790"
     CDS             3296..4642
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0008410 - CoA-transferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033530.1"
                     /locus_tag="BKN51_RS05870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_05790"
                     /product="CoA transferase"
                     /protein_id="WP_101613066.1"
                     /transl_table=11
                     /translation="MDSRVWTTLTGDTLAEDAVEVTGPESVLPGTFRVEEAATTSIAAA
                     TLAAGELLRLRGIEPGKVSVDTRHAAASFHSEQYIRVDGEPVPFSAPLSGDYRANDGWV
                     RLHCNYPRHVSAVCWGLGVPATRAAFEKVVAAKSKFEVESAVVGAGGAAAVLRSREEWL
                     AHKQGQASSALPVAEIRSLGPSDPVRLFDSDRPLGGVRILDLTHVIAGPVAGRVLAAHG
                     ATVMHIGADRLPTVPPLAVDTGMGKLSAYVDLETEAGRSRLRKLIARADVVLQGFRPGS
                     LVAKGFTPEAIAESRPGIVVADLSAYGWEGPWARRRGFDSLVQMASGIADEGGKTAGID
                     GPGPLPVQALDHATGWLTAAAIMTALRRAATEGGSQHVRTSLAGTGEWLNSLGRKEPGP
                     TGFDGGEWLEEAESPLGRLTRVKMAGVLPGSNPFWVEGTRVPGSDRAVW"
     gene            complement(4660..5004)
                     /locus_tag="BKN51_RS05875"
                     /old_locus_tag="BKN51_05795"
     CDS             complement(4660..5004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033529.1"
                     /locus_tag="BKN51_RS05875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_05795"
                     /product="hypothetical protein"
                     /protein_id="WP_101606646.1"
                     /transl_table=11
                     /translation="MTSPRERLAGQQAELLKALLAGGDPPAGFDADRLRIEANVLRNKQ
                     SRLAVYLRPDLAEALGDRFGALFREYATAHPKTDTIRARAYADAFGTWLVERGEIPKPK
                     GRLARWLHRV"
     gene            complement(5001..5813)
                     /locus_tag="BKN51_RS05880"
                     /old_locus_tag="BKN51_05800"
     CDS             complement(5001..5813)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005157007.1"
                     /locus_tag="BKN51_RS05880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_05800"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_101606647.1"
                     /sec_met_domain="DUF692 (E-value: 1.2e-82, bitscore: 276.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADAPGHLGIGIGWRHELDLSIARLPGVDWVEVVAENLHTGHLPE
                     TLIALRDKGIPVLPHAVSLSLGGAGPVDTDRVEQLAEVTRELGAPMASDHVCFVRAGGL
                     DSGHLMPLPRTREALDVLVDNVKLTQSIVDVPFALENIAAVLEWPDAEFTESEFLRELT
                     DRTGCLLIIDVANLYANARNLGTDPERFLDEIPWERLAYTHMAGGVERDGVYHDTHAHP
                     VVPEVLDLLRELRKRVAPPGVLLERDDDYPPDSELAAELAALREAVTP"
     gene            complement(5806..6756)
                     /locus_tag="BKN51_RS05885"
                     /old_locus_tag="BKN51_05805"
     CDS             complement(5806..6756)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033527.1"
                     /locus_tag="BKN51_RS05885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_05805"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_101606648.1"
                     /transl_table=11
                     /translation="MEDTWGIPGPTFLAIYAVLLVFPLALGLLWTISVKLDRKTSRGTV
                     NGPQPTVYELAYLAGGPDRVVDTAIAALVDRGTLRVSSSKQLQLTGAEPADPIERAVAK
                     GARPGYNATTRGIRDRLRMSGPMQALGKDLEARGLVVIDQAPQIRRVVANLYLGVMILG
                     LVRVFAGILGDHPVGFLIPLVIVASLATLFSRIAKNKRTGPRPTSEGNRILGSANSALA
                     RERKRGIPNAPAMGGMAGGAMLGGAAAAVALGGLAFYPDEELSAALIPPPMPGAFGGGG
                     SSGGSTCSTGSSCSGGSSCGGGGSSCGGGGGGCGG"
     misc_feature    complement(6825..6840)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.93"
                     /tool="antismash"
     gene            complement(6837..7640)
                     /locus_tag="BKN51_RS05890"
                     /old_locus_tag="BKN51_05810"
     CDS             complement(6837..7640)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637335.1"
                     /locus_tag="BKN51_RS05890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_05810"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_233224232.1"
                     /transl_table=11
                     /translation="MAELETVMAVLAALPLLAALTYTRWLRNRRHDGEPPRTIYQVAYL
                     AGGPDRVSDTAVAGAVERRVARLDSSGVLRRTSARSADPFLLAVADSLPKVRAARVRES
                     LRGSEPMRSLRAELLDGGLVVPEGRLRRVWRAAVVAHLGLVVLGAAVLIRTVVITERSI
                     ALAGIALAVTTTACAVTVRLERVHRAVWTTKAGERALSRAGGDPQLVTGAMGAVALGGI
                     DAYPDRRLARLLTLTTPSSRRKAQVDVCNGASPDGLTAVADGSPG"
     gene            complement(7633..8196)
                     /locus_tag="BKN51_RS05895"
                     /old_locus_tag="BKN51_05815"
     CDS             complement(7633..8196)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033525.1"
                     /locus_tag="BKN51_RS05895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_05815"
                     /product="hypothetical protein"
                     /protein_id="WP_101606649.1"
                     /transl_table=11
                     /translation="MSDPWGISGPDFAWLAFLPLLERHGLQRRGLQVAENRRRLGWRCA
                     MAVYVAVLALGIARLANAVPLKRPVAILVVLMVGVVGALGLIVWLQLPDRSGRATTQGT
                     LALRYGDGDREPGRTAAGRVALYGFGAHPDPAIAAVLGKTGDTRGNRFTGMVGSSCSGG
                     TYIAAGSSCGGGGSSCGGGGGCGG"
     misc_feature    complement(7921..7923)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8275..8697)
                     /gene="msrB"
                     /locus_tag="BKN51_RS05900"
                     /old_locus_tag="BKN51_05820"
     CDS             complement(8275..8697)
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333001.1"
                     /locus_tag="BKN51_RS05900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_05820"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_101613068.1"
                     /transl_table=11
                     /translation="MKPVVGATPRVVKSEQEWREQLSPDEYAVLRQAGTERPFTGEYTD
                     AKTTGVYQCRACGAELFRSDTKFESHCGWPSFYDPADTEAVLLREDTAMGMRRIEVLCK
                     SCHSHLGHVFEGEGYATPTDQRYCINSISLTLVPES"
     gene            complement(8717..9022)
                     /locus_tag="BKN51_RS05905"
                     /old_locus_tag="BKN51_05825"
     CDS             complement(8717..9022)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033523.1"
                     /locus_tag="BKN51_RS05905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_05825"
                     /product="hypothetical protein"
                     /protein_id="WP_101606650.1"
                     /transl_table=11
                     /translation="MADSGPFGPGQNPRFDEDLVGLDPYDPEARAFAEHLDRIERCGPN
                     FTVEACLDGVSDFADSSNRLGGLRWWVSALVVILIVLGVMVTAWDIIGRAIAWLAG"
     gene            complement(9077..10735)
                     /locus_tag="BKN51_RS05910"
                     /old_locus_tag="BKN51_05830"
     CDS             complement(9077..10735)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005157015.1"
                     /locus_tag="BKN51_RS05910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BKN51_05830"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_255414918.1"
                     /sec_met_domain="Pkinase (E-value: 1.8e-53, bitscore:
                     180.5, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAGHYRLVEQIGSGAMGVVWRAIDVRLERSVAVKQILPQPGVSE
                     AERDNMRQRAMREAKNAARFQHPNAIVVFDIAEDGGDPCLVMEYLNGPSLSAIISDEGT
                     LPLGRVAKIGEQVASALVAAHRAGIVHRDVKPGNILIDESGTAKITDFGISRAAGDMTL
                     TQTGLIGGTPAYLAPELARGSDPVPSSDVFALGATLYQAIEGQTPYGNSSNQLALLYAA
                     ANGQINPPQQAGAATALLMSLLRTEPTERPSMAEAQQRLAALAANESGAGTAASPRLFG
                     AGGGRQPAAPDTPGRGNPGGDRPPWQRTEQPAQSAAAPPPPPPAKQHTPTAAFIPMRSQ
                     SAPPNTPPRPVAAASPPPSAAAPMRPSSGKPADGKRKAVLFAGAGAAVVVIAVIVFLVL
                     NSSNGTTGNQGGDNAGANPQSSTSAPKSTAPSSSKAAPAGLGKTPSEKVTSYSSVGGFV
                     LDFFDTDKIGTSASWNKLTDAAKEVYGSEQAFAEYWSAHKVTGADTARADKGGGNADGS
                     IDMNITLNKGVRPALRVVQVGGQYFIDADTRVLGN"
ORIGIN
        1 ctgacgtcat cgcggtcacc aaccgactgt aagacgcgat agtccggttc ggggcgcaga
       61 cgcgccgaga gtaagggccc ggagcgccca tggcaccatg aaccgtgatg tctccttcag
      121 ctgcttctcc cgcgcagacc gtccccgcgg cccgtcgcgc cctgcccggc gcgccgttcc
      181 tggccgccgc gcgcggcgaa cgcccggccc gcacccccgt gtggttcatg cgccaggcag
      241 gccggtcgct gcccgagtac cgggcgctgc gcgagggcac ctcgatgttc gacgcgtgct
      301 tcgaccccga gatgctcgcc gagatcacgc tccagccgat ccgccgtcac ggcgtcgacg
      361 cggccatcct cttcagtgac atcgtcgtcc cgctcaaggc ggcggggctc gacatcgaca
      421 tcgtcgcggg caccggcccg gtcgtggccg agccgatccg cgacgccgcg ggcgtgcgcg
      481 cgctgccggt cctggacccg gagcaggtgg agcgggtcgc cgacggcgtc cggctgctgg
      541 tcgggtcgct gggcgagaca ccgctgatcg ggttcgccgg cgcgccgttc accctggcct
      601 cctatctcat cgagggcggg ccgagccgca accacgagca caccaaggcg ctcatgcact
      661 ccgagccgga gctgtggcac gagctggccg ggcgcctggc ggacatggcg atcaccttcc
      721 tgtccgcgca gctcgacgcc ggggccgacg cgatccagct gttcgactcg tgggcgggcg
      781 cgctctcgga gcgggactac cgcgagttcg tcctgccgca ttcggcgaag gtgctgtcgg
      841 cggtcgccgc ctacggcgtg ccccggatcc acttcggcgt cggcaccggc gagctgctgg
      901 tcgcgatgcg cgacgcgggc gccgacgtgg tcggcgtcga ctggcgcctc ccgctcgacg
      961 aagccgtccg gcggctcggc ggcggtgtcg tccagggcaa cctcgacccc gcgctgctgc
     1021 acgcgtcctg gccggtgctc gaagcggagg tccggcggat ccacgccgag ggccgcgcgg
     1081 ccgacggtca catcttcaac ctcggccacg gcgtcctgcc cggcgtcgac ccggacgtct
     1141 tgacgcgcgt ggtcgggctg gtgcacgagc tccagccgtg agcaccgtga agaccgccgc
     1201 cgtcgtcggt ggcggtatct cgggactgac cgcggcctac cgcctgcgga cgctgctcgg
     1261 cgaagaagcc cggatcgtcg tcttcgaagc gaccgagtcc ctcggcggaa aactccgcac
     1321 gatcgaactc gccggtgagc gctacgacgt cggcgcggag gccttcctcg cccggcgacc
     1381 cgaggcgctc gccctggtcc gcgaggtcgg gctgggcgag agtctcgtcc accccaccaa
     1441 ggcccgcgcg aagatccacg ccggcggatc cgtgctcggc ctgccgccgg gcacggtcat
     1501 gggtgttccc gcctcggccg acgcggtcgc cggggtgctg tcggagaagg gccgcgccct
     1561 ggtcgaggcc gagtcttcgc tggcgccggt ggaactgccc gccggggacg tgccgctcgg
     1621 cccgctgctg cgcgagcggt tcggcgacga actcgtggac cgcctcgtcg acccgctgct
     1681 cggcggggtc tacgccgggg gagcggacgg gctcgggctg cgcgcgacga tgcccgggct
     1741 ggcgtccgcg gtggaccgcg gcgcgcgttc gctcaccgaa ggcgcggcct cgctcatgcc
     1801 cgcttcgccg agtacggcgc cggtcttcgg cactctgctg ggcgggctcg gcaccctgat
     1861 ccggcgcctc gcggagctgt cccgcgccga gatccggacc gggaccacgg tgacggcgat
     1921 cgagcgcacc gccaccggct ggaaggtcga cgacctcgac gccgactcag tccttctcgc
     1981 ggttccggcg ccctcggcgc ggcggctgct cgacggcgtc gtgggtgtgg cgtcgtcggc
     2041 gttcgcggag gtcgagctgg cgtcgatggc ggtgatcgcg ctcgcgctgc cgccgggcac
     2101 cgaactgccg gagtcgtccg gggtgctgat cggcgccggt gaacaggacg cggccgggaa
     2161 accgttcgcg gccaaggcgt tcaccttctc cacgcgcaag tgggcgcagt acggcgaagg
     2221 cccggtgctg gtgcgcggct cggtcggccg cttcggcgaa ccgggcgcgc tgcacgccga
     2281 cgacgacgaa ctcgtccggg tggtccgtga cgacctggcc cggctgaccg gggtcaccgc
     2341 agcgccgatc gaaacgctgg tcacgcgttg gggcggcggg ctcccgcagt acggcaccgg
     2401 tcacctcgaa ctcgtcgagc gcgtcgaacg cgccgtcgcg gaggtcccgg ggctcgccgt
     2461 ggcgggcgcg acgctgcacg gcgtcgggct cccggcctgc atcgccaccg ccgacgcggc
     2521 cgcccggcgc atcgccggga tcacaccgac ccacgagggc tcctgagcac cggcagtgcc
     2581 aagatggcgg tatggcgcgg ctgaactaca acgagctcaa tgacaccatc cgctacaccg
     2641 cctggtcggt cttccgggcc gagcagggca agctcggcga tgatcgcgcg caggcgaccg
     2701 cggagaccac ggagtacctg gacgcgctgg aggccaaggg cgtcgtcgtc cgcgggctct
     2761 acgacctttc cgggctgcgg gccgacgccg actacatggt ctggtggcac gccgaggaga
     2821 tcgagcaggt ccaggcggcc tacagcggtt tccggcacac cccgctcggc cgcgcctcgg
     2881 ttccggtgtg gagccaggtc gcgctgcacc gtccggcgga gttcaacaag agccacatcc
     2941 cggcgttcct cgccggtgaa gaggcccgca agttcatctg cgtctatccg ttcgtgcgct
     3001 cctacgagtg gtacctgctg ccggacgacg agcgccgcaa gatgctggcc gaccacggca
     3061 aggaggcccg cgactacccg gacgtccgcg ccaacacggt cgcgtcgttc gcgctgggcg
     3121 actacgagtg gatcctggcc ttcgaggccg acgagctgca ccgcatcgtc gacctgatgc
     3181 gccacctgcg cggcaccgag gcccgcctcc acgtgcgcga ggagatcccg ttctacaccg
     3241 ggacgaaggt ggaacccgcc gaactgatca ccctgctgcc gtagtgaacg cttcagtgga
     3301 ctcccgcgtc tggaccacgc tcaccggcga cacgctcgcc gaagacgccg tcgaggtcac
     3361 cggccccgaa tccgtgctgc ccgggacctt ccgggtcgag gaagccgcga ccaccagtat
     3421 cgccgcggcg acgctggcgg ccggggaact gttgcggctg cggggaatcg agccgggcaa
     3481 ggtctcggtc gacacccggc acgcggcggc gtccttccac agcgagcagt acatccgggt
     3541 cgacggggaa ccggtgccgt tcagcgcgcc gctgtccggc gactaccgcg cgaacgacgg
     3601 ctgggtgcgg ctgcactgca actacccgcg tcacgtctcc gcggtgtgct ggggcctcgg
     3661 tgtcccggcg acccgcgcgg ctttcgaaaa ggtcgtggcg gccaagtcga agttcgaggt
     3721 cgagtcggcg gtggtcggcg ccggcggtgc cgcggccgtg ctgcgctccc gtgaggaatg
     3781 gctggcgcac aagcaaggac aggcctcttc ggcgttgcct gtcgccgaga tccggtcgct
     3841 cgggccgtcg gatccggtgc ggctgttcga ttccgaccgg ccgctgggcg gggtgcggat
     3901 cctcgatctg acccacgtca tcgccggacc ggtcgcgggc cgcgtgctcg ccgcgcacgg
     3961 cgccaccgtc atgcacatcg gcgcggaccg cctgccgacc gtgccgcccc tggccgtcga
     4021 caccggcatg ggcaagctct cggcgtacgt cgatctggag accgaagccg ggcgctcgag
     4081 gctgcgcaag ctgatcgcgc gtgccgacgt cgtcctgcag ggcttccggc cgggatcgct
     4141 ggtggccaag ggtttcactc cggaggcgat cgccgaatcc cggcccggga tcgtggtcgc
     4201 tgacctgtcc gcctacggct gggaaggccc ctgggcgcgc aggcgagggt tcgacagcct
     4261 ggtgcagatg gcctcgggga tcgccgacga aggcggcaag accgccggga tcgacggtcc
     4321 gggaccgctt ccggtgcagg cgctcgacca cgcgaccggc tggctcaccg cggcggcgat
     4381 catgaccgcg ctccgcaggg cggccaccga gggcggtagt cagcacgtcc ggacctcgct
     4441 cgccgggacg ggggagtggc tgaattcgtt gggccgcaag gaacccgggc ccaccggttt
     4501 cgacggcggc gaatggctgg aggaggccga aagcccgctc gggcggctga cccgggtcaa
     4561 gatggccggg gtgctgccgg gctcgaatcc cttctgggtg gagggcacgc gcgtacccgg
     4621 aagcgaccgt gccgtctggt gaccaccgca gctagaggac taaacgcggt gtagccacct
     4681 cgccaaacgg cccttcggct tcggtatctc gccgcgttcc acgagccacg tgccgaacgc
     4741 gtccgcgtaa gcccgcgcgc ggatcgtgtc ggtcttcgga tgcgccgtcg cgtactcgcg
     4801 gaacagcgcg ccgaaccggt cgccgagggc ctcggcgagg tccggccgca ggtacacggc
     4861 cagcctgctc tgtttgttcc gcaagacgtt cgcttcgatg cggagcctgt ccgcgtcgaa
     4921 acccgccgga gggtcgcctc cggcgaggag cgccttgagc agttcggcct gttgcccggc
     4981 gagccgctcc cggggcgagg tcacggcgtg accgcttccc ggagcgcggc cagttcggcg
     5041 gccagttcgc tgtcgggcgg gtagtcgtcg tcgcgttcca gcaggacacc cggtggggcg
     5101 acgcgcttcc gcagctcccg cagcaggtcc agcacctccg ggacgaccgg gtgggcgtgc
     5161 gtgtcgtggt agacgccgtc gcgttcgaca ccgcccgcca tatgcgtgta cgccagccgc
     5221 tcccacggga tctcgtcgag gaaccgttcg ggatcggtgc cgaggttgcg ggcgttggcg
     5281 tacaggttgg cgacgtcgat gatcagcagg cagccggtcc ggtcggtgag ttcgcgcagg
     5341 aactccgact cggtgaactc cgcgtccggc cactccagca ccgccgcgat gttctccagc
     5401 gcgaacggga cgtccacgat ggactgggtc agtttgacgt tgtccaccag gacgtcgagc
     5461 gcttcccggg tgcgggggag cggcatcaga tgccccgagt cgagcccgcc cgcgcggacg
     5521 aagcacacgt ggtcgctggc catcggcgct ccgagttcac gggtgacctc cgcgagctgc
     5581 tcgacgcggt cggtgtccac cggccccgcc ccgcccagcg acagcgagac cgcgtgcggc
     5641 aggacgggga ttcccttgtc gcgcaaggcg atcagggttt cgggaagatg accggtgtgc
     5701 aggttctcgg cgacgacctc gacccagtcg acgccgggca gccgcgctat cgacaggtcc
     5761 agctcgtgcc gccagccgat gccgatgccg aggtggcccg gtgcgtcagc caccgcaacc
     5821 cccgccgccg cctccgcagg agctgccacc gccgccgcac gagcttccgc cgctgcacga
     5881 ggagccggtg ctgcaggtgc tgccaccgga ggagccaccg ccaccgaagg cgccgggcat
     5941 gggcggcggg atcagcgccg cgctgagctc ttcgtccggg tagaaggcga gtccgcccaa
     6001 agcgacggcc gcggcggcgc cgcccagcat ggctccaccg gccataccgc ccatcgcggg
     6061 cgcgttgggg atcccgcgct tgcgctcccg cgccagggca ctgttggcgc tcccgaggat
     6121 ccggttgcct tcgctggtcg ggcgcggccc ggtccgcttg ttcttggcga tccgggagaa
     6181 caaggtcgcg agcgaggcca cgatcaccag cgggatcagg aaaccgaccg gatggtcgcc
     6241 gaggatcccg gcgaacacgc gcaccaggcc gaggatcatc acacccaggt agaggttggc
     6301 cacgacccgg cggatctgcg gcgcctggtc gatgacgacg agtccccgcg cttccagatc
     6361 cttgccgagc gcctgcatcg gccccgacat ccgcagccgg tcgcgaatgc cgcgcgtcgt
     6421 ggcgttgtag cccggccggg cgcccttggc gacggccctc tcgatcgggt ccgcgggctc
     6481 ggctcccgtc agctggagct gcttcgagct gctgacccgc agcgtcccgc ggtcgaccaa
     6541 ggccgcgatg gccgtgtcga cgacgcggtc cgggccgccc gcgagatagg cgagttcgta
     6601 caccgtcggt tgcggtccgt tcaccgtgcc gcgcgacgtc ttgcggtcca gcttgaccga
     6661 gatggtccac agaagaccta gggccagcgg gaacaccagc aggacggcgt agatagccag
     6721 gaaagtgggt ccgggaatgc cccaggtgtc ttccatcgca cgggcctttc acgagcaggt
     6781 gcacttaccg tagtcggacg cttttccgtc cggtcatggt tccccggacc agtcgatcag
     6841 cccggcgaac cgtccgcgac ggccgttaga ccgtcaggag aggcaccgtt gcagacgtcg
     6901 acttgggctt tgcggcggga agaaggcgtc gtcagggtca ggagccgcgc caaccgccga
     6961 tccggatagg cgtcgatgcc acccagcgcc accgcgccca tcgcgccggt gacgagctgc
     7021 ggatcgccgc cggcccgcga gagcgcccgc tcgcccgctt tcgtggtcca caccgcgcga
     7081 tggacgcgct cgagccggac ggtgacggcg cacgccgtcg tcgtgacggc cagcgcgatt
     7141 ccggcgagcg cgatggaccg ctcggtgatc acgacggtgc ggatgagcac cgccgccccg
     7201 agcaccacga gcccgaggtg cgcgaccacg gcggcgcgcc acacccggcg cagacgccct
     7261 tccggaacga ccaggccgcc gtcgagcaac tccgcccgca gcgagcgcat cggttccgac
     7321 ccgcgcagcg attcgcgcac cctcgccgcc cgcaccttcg gcaggctgtc cgccaccgcg
     7381 agcaggaacg ggtccgcgga gcgcgcggag gtccggcgca ggacgccgga gctgtcgagg
     7441 cgggccaccc gccgctcgac ggcgcccgcg acggcggtgt ccgagacccg gtcgggtccg
     7501 ccggcgaggt aggcgacctg gtagatcgtg cgcggcggtt cgccgtcgtg acgccggttc
     7561 cgcagccacc gcgtgtacgt cagtgccgcg aggagcggaa gcgccgcgag cacggccatg
     7621 acggtctcga gttcagccac cgcaaccacc tccaccacca cacgaagaac cgccgccgcc
     7681 gcaggacgag cccgccgcaa tgtacgtgcc cccggagcac gaggagccca ccatgcccgt
     7741 gaaccggttg ccgcgggtgt caccggtctt gcccagcacg gccgcgatcg ccggatcggg
     7801 gtgggccccg aagccgtaaa gcgcgaccct cccggcagcg gtcctgcccg gttcgcggtc
     7861 cccgtcgccg taccggagcg ccagcgtgcc ctgggtggtc gcgcggccgg acctgtccgg
     7921 taactgcaac cacacgatca ggccgagtgc gccgaccaca ccgaccatca ggacgacgag
     7981 gatggcgacc ggccgcttca gcggtacggc gttcgccagc cgcgcgatcc ccagcgccag
     8041 aacggcgacg tacacggcca tcgcgcaccg ccagcccaga cggcggcggt tctcggcgac
     8101 ttgcagacct cttcgctgga ggccgtgccg ttcgagcaac gggagaaacg cgagccaggc
     8161 gaagtccggt ccgctgatac cccaggggtc actcatatga agacaccgcc ctccccgacg
     8221 ctgttcctgt tcaacgggaa cgcgtcgggg agggcggtgg ttcgcttcgg ttggttacga
     8281 ctcgggaacg agcgtcagcg agatcgagtt gatgcagtac cgctgatccg tcggcgtcgc
     8341 gtacccctcg ccttcgaaga cgtgcccgag gtggctgtgg cacgacttgc acagcacctc
     8401 gatccggcgc atccccatgg cggtgtcctc acggaggagg acggcttcgg tatcggcggg
     8461 gtcgtagaac gacggccagc cgcagtggct ctcgaacttc gtatcgctgc ggaacagctc
     8521 ggcgccacag gcacggcact ggtacacacc ggtggtcttg gcgtcggtgt actccccggt
     8581 gaaggggcgc tcggtgcccg cctggcggag cacggcgtac tcgtcggggc tgagctgttc
     8641 ccgccattcc tgctcggact tgaccacgcg tggcgtggct ccgacaacgg gtttcatgcc
     8701 tttcaccggt tccacgttac cccgcgagcc acgcgatggc ccggccgatg atgtcccatg
     8761 cggtgaccat cacgccgagc acgatgagga tcaccacgag tgccgaaacc caccagcgca
     8821 gaccgccgag acggttgctg gagtcggcga aatcggagac accgtcgagg caggcttcca
     8881 cggtgaaatt ggggccgcag cgttcgatgc ggtccaggtg ctcggcgaag gcacgggctt
     8941 cggggtcgta cgggtcgagg cctaccaggt cctcgtcgaa acgaggattc tggccaggtc
     9001 cgaaaggtcc gctatcggcc atgcgagcaa cagtaagcca agagcggcga ttggcctacc
     9061 accagcgagg cgggtctcag ttgccgagta ctcgcgtgtc ggcgtcgatg aagtactggc
     9121 cgccgacctg gacgacgcgc agcgcgggac ggactccctt gttgagcgtg atgttcatgt
     9181 cgatcgagcc gtcggcgttg ccgccgccct tgtccgcccg ggcggtgtcg gcgccggtga
     9241 ccttgtgggc actccagtat tcggcgaaag cctgctccga gccgtagacc tctttcgcgg
     9301 cgtccgtgag cttgttccag ctcgcggagg tcccgatctt gtccgtgtcg aagaagtcga
     9361 ggacgaagcc gccgacgctc gaatagctcg tgaccttctc gctcggggtc ttccccaggc
     9421 ccgccggggc ggccttcgag gacgacggcg cggtcgactt gggcgccgag gtgctggact
     9481 gcgggttcgc cccggcgttg tcgccgccct ggttgccggt ggtcccgttg ctcgaattca
     9541 gcaccaggaa cacgatcacc gcgatcacca cgaccgcggc accggcgccc gcgaacagga
     9601 cggccttgcg tttgccgtcg gcgggtttcc ccgaggacgg ccgcatcggg gcggccgcgg
     9661 acggcggcgg gctcgccgcg gcgaccggcc gcggcggggt gttcggcggg gccgactgcg
     9721 agcgcatcgg gatgaacgcc gctgtcggcg tgtgctgctt ggccggagga ggcgggggag
     9781 gtgccgcggc ggactgcgcg ggctgctcgg tccgctgcca cggcggccgg tccccgccgg
     9841 ggttgccgcg tcccggggtg tcgggcgcgg cgggctgtct gccgccgccc gctccgaaga
     9901 gccgcggcga cgccgccgtg cccgcgccgg attcgttcgc cgccagcgcg gcgagccgct
     9961 gctgggcctc ggccatgctc gggcgttcgg tcggttcggt gcgcaggagg ctcatcaaca
    10021 gcgccgtcgc ggcgcccgcc tgctgcggcg ggttgatctg cccgttcgcg gccgcgtaca
    10081 gcagcgcgag ctggttggag ctgttcccgt acggcgtctg gccctcgatc gcctggtaga
    10141 gcgtcgcgcc gagcgcgaag acatcggagc tgggcaccgg gtcggagccg cgcgccagct
    10201 ccggcgcgag gtaggccggg gtgccgccga tcaggccggt ctgggtgagc gtcatgtcgc
    10261 cggccgcgcg ggagatgccg aagtcggtga tcttggcggt acccgactcg tcgatcagga
    10321 tgttgcccgg tttgacgtca cggtgcacga tcccggcgcg gtgcgcggcg accagcgccg
    10381 acgcgacctg ctcgccgatc ttcgcgacgc gccccagcgg cagcgtgccc tcgtcggaga
    10441 tgatcgccga aagactcggg ccgttcaggt actccatcac caggcagggg tcgccgccgt
    10501 cttcggcgat gtcgaacacc acgatcgcgt tcggatgctg gaagcgggcc gcgttcttcg
    10561 cctcgcgcat ggcgcgctgg cgcatgttgt cgcgttcggc ttcggagaca cccggctggg
    10621 ggaggatctg cttgaccgcc accgagcgct cgaggcggac atcgatggca cgccagacca
    10681 cccccatggc accgctacca atttgctcga ccaggcgata gtgcccagcg atcagctgac
    10741 cggtgtcgat ggcgactgct cctgacacat tcccggggtg atggtggcgt tacgcggtcg
    10801 tgatggtccc gcg
//
