GCF_002836835.1 - 10 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_PIZP01000001.1 (Staphylococcus shinii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor	186,732	207,616
Region 1.2	terpene	308,056	328,874

NZ_PIZP01000014.1 (Staphylococcus shinii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	RiPP-like	3,256	15,670

NZ_PIZP01000002.1 (Staphylococcus shinii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	T3PKS,RiPP-like	251,513	302,935

NZ_PIZP01000004.1 (Staphylococcus shinii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 17.1	terpene,opine-like-metallophore	137,299	176,527	High	staphylopine	other:other
Region 17.2	NRPS	206,676	251,004
Region 17.3	lanthipeptide-class-iii	255,599	278,157

NZ_PIZP01000006.1 (Staphylococcus shinii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 19.1	NRPS	123,274	180,070

NZ_PIZP01000008.1 (Staphylococcus shinii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	NI-siderophore	1	32,537	High	staphyloferrin A	other:non-nrp siderophore

NZ_PIZP01000009.1 (Staphylococcus shinii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 22.1	cyclic-lactone-autoinducer	18,930	39,639

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor	186,732	207,616
Region 1.2	terpene	308,056	328,874
Region 6.1	RiPP-like	3,256	15,670
Region 11.1	T3PKS,RiPP-like	251,513	302,935
Region 17.1	terpene,opine-like-metallophore	137,299	176,527	High	staphylopine	other:other
Region 17.2	NRPS	206,676	251,004
Region 17.3	lanthipeptide-class-iii	255,599	278,157
Region 19.1	NRPS	123,274	180,070
Region 21.1	NI-siderophore	1	32,537	High	staphyloferrin A	other:non-nrp siderophore
Region 22.1	cyclic-lactone-autoinducer	18,930	39,639

No secondary metabolite regions were found in these records:: NZ_PIZP01000010.1 (Staphylococcus shinii); NZ_PIZP01000012.1 (Staphylococcus shinii); NZ_PIZP01000013.1 (Staphylococcus shinii); NZ_PIZP01000007.1 (Staphylococcus shinii); NZ_PIZP01000015.1 (Staphylococcus shinii); NZ_PIZP01000016.1 (Staphylococcus shinii); NZ_PIZP01000017.1 (Staphylococcus shinii); NZ_PIZP01000018.1 (Staphylococcus shinii); NZ_PIZP01000019.1 (Staphylococcus shinii); NZ_PIZP01000020.1 (Staphylococcus shinii); NZ_PIZP01000021.1 (Staphylococcus shinii); NZ_PIZP01000022.1 (Staphylococcus shinii); NZ_PIZP01000003.1 (Staphylococcus shinii); NZ_PIZP01000005.1 (Staphylococcus shinii); NZ_PIZP01000011.1 (Staphylococcus shinii)

Compact view

NZ_PIZP01000001.1 - Region 1 - terpene-precursor

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Location: 186,732 - 207,616 nt. (total: 20,885 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

CW747_RS00900: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: carboxylase

CW747_RS00950: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: peptidase

CW747_RS00965: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthase synthetase

CW747_RS00890: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

CW747_RS00925: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001534.3	0.66	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0001535.3	0.44	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000234.5	0.42	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000677.5	0.41	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002284.3	0.40	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001529.5	0.40	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001605.3	0.40	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000906.3	0.40	other (other)	heme D1	Heliophilum fasciatum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001534.3	0.66	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0001535.3	0.44	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000234.5	0.42	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000677.5	0.41	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002284.3	0.40	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001529.5	0.40	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001605.3	0.40	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000906.3	0.40	other (other)	heme D1	Heliophilum fasciatum

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

CW747_RS00925: PT_FPPS_like

Domain 1 (29 - 292): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.28 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.58 out of 20.97

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.16 out of 32.93

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.54 out of 26.06

Confidence: medium

Additional weak hits (2):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.05 out of 30.97

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.26 out of 27.04

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_PIZP01000001.1 - Region 2 - terpene

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Location: 308,056 - 328,874 nt. (total: 20,819 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

CW747_RS01590: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000859.3	0.47	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0001685.3	0.46	other (other)	N-acyloxyacyl lysine	Raoultella ornithinolytica 10-5246
BGC0000854.3	0.37	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0002382.3	0.32	ribosomal	grimoviridin	Grimontia marina
BGC0002633.2	0.31	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0002470.2	0.30	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002
BGC0000402.4	0.30	NRPS	paenilarvin A, paenilarvin B, paenilarvin C	Paenibacillus larvae subsp. larvae DSM 25430
BGC0000906.3	0.28	other (other)	heme D1	Heliophilum fasciatum
BGC0000905.5	0.28	other (other)	heme D1	Heliobacillus mobilis
BGC0001098.5	0.26	NRPS, PKS	iturin	Bacillus subtilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000859.3	0.47	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0001685.3	0.46	other (other)	N-acyloxyacyl lysine	Raoultella ornithinolytica 10-5246
BGC0000854.3	0.37	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0002382.3	0.32	ribosomal	grimoviridin	Grimontia marina
BGC0002633.2	0.31	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0002470.2	0.30	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002
BGC0000402.4	0.30	NRPS	paenilarvin A, paenilarvin B, paenilarvin C	Paenibacillus larvae subsp. larvae DSM 25430
BGC0000906.3	0.28	other (other)	heme D1	Heliophilum fasciatum
BGC0000905.5	0.28	other (other)	heme D1	Heliobacillus mobilis
BGC0001098.5	0.26	NRPS, PKS	iturin	Bacillus subtilis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

CW747_RS01565: PT_phytoene_like

Domain 1 (13 - 251): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → PSPP; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 21.84 out of 21.84

Confidence: strong

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.46 out of 29.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 26.45 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.99 out of 30.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.20 out of 28.19

Confidence: medium

Additional weak hits (1):

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.78 out of 29.65

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator
MexT	Global virulence regulator
PerR	Peroxide regulator
SypG	Regulator of biofilm formation and host colonization
ZuR variant 1	Zinc-responsive repressor

NZ_PIZP01000014.1 - Region 1 - RiPP-like

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Location: 3,256 - 15,670 nt. (total: 12,415 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CW747_RS14370: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0002700.2	0.50	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000617.5	0.49	ribosomal	coagulin	Bacillus coagulans
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002579.2	0.47	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000624.3	0.45	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0001862.4	0.45	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000619.3	0.45	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001388.3	0.45	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001602.3	0.45	ribosomal	gassericin-T	Lactobacillus gasseri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0002700.2	0.50	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000617.5	0.49	ribosomal	coagulin	Bacillus coagulans
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002579.2	0.47	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000624.3	0.45	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0001862.4	0.45	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000619.3	0.45	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001388.3	0.45	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001602.3	0.45	ribosomal	gassericin-T	Lactobacillus gasseri

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.28 out of 27.55

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes

NZ_PIZP01000002.1 - Region 1 - RiPP-like,T3PKS

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Location: 251,513 - 302,935 nt. (total: 51,423 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase reductase

CW747_RS04120: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

CW747_RS04155: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

CW747_RS04225: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

CW747_RS04290: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase phosphotransferase

CW747_RS04105: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

CW747_RS04110: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

CW747_RS04160: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

CW747_RS04250: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

Hydrolases: hydrolase

CW747_RS04075: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

CW747_RS04200: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

Ligases: synthase

CW747_RS04165: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Translocases: transport

CW747_RS04215: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000888.5	0.17	other (other)	bacilysin	Bacillus sp. CS93
BGC0002556.2	0.16	other (other)	cervinomycin B3, cervinomycin C1, cervinomycin C2, cervinomycin C3, cervinomycin C4	Streptomyces sp.
BGC0000866.5	0.16	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0001928.2	0.15	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000867.3	0.15	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001184.4	0.14	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0001039.5	0.13	NRPS, PKS	pyridomycin	Streptomyces pyridomyceticus
BGC0002370.2	0.12	NRPS	zelkovamycin B, zelkovamycin C, zelkovamycin D, zelkovamycin E	Actinomadura graeca
BGC0000255.5	0.12	PKS	pederin	Uncultured bacterium
BGC0002561.3	0.12	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.51	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0001928.2	0.50	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000867.3	0.49	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000888.5	0.48	other (other)	bacilysin	Bacillus sp. CS93
BGC0001184.4	0.46	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000205.3	0.44	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002561.3	0.43	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000671.3	0.43	terpene	momilactone B	Oryza sativa Japonica Group
BGC0000255.5	0.42	PKS	pederin	Uncultured bacterium
BGC0000509.4	0.42	ribosomal	epilancin 15x	Staphylococcus epidermidis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.81 out of 29.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.28 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 27.71 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.21 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.30 out of 28.19

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.91 out of 32.93

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.44 out of 26.06

Confidence: medium

Additional weak hits (4):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.17 out of 27.55

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.33 out of 36.54

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.73 out of 32.74

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.57 out of 35.63

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
SypG	Regulator of biofilm formation and host colonization
ZuR variant 1	Zinc-responsive repressor

NZ_PIZP01000004.1 - Region 1 - opine-like-metallophore,terpene

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Location: 137,299 - 176,527 nt. (total: 39,229 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)
opine-like-metallophore: (CntL and CntM)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

CW747_RS07655: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

CW747_RS07670: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

CW747_RS07780: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Lyases: dehydratase

CW747_RS07685: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

CW747_RS07665: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002487.3	0.62	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0002488.3	0.51	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0002490.2	0.25	other (other)	yersinopine	Yersinia pestis CO92
BGC0000647.3	0.23	terpene	carotenoid	Rhodobacter sphaeroides
BGC0002489.2	0.20	other (other)	pseudopaline	Pseudomonas aeruginosa PAO1
BGC0000646.5	0.17	terpene	β-carotein	uncultured bacterium
BGC0000645.3	0.16	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0002306.2	0.13	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000648.3	0.13	terpene	carotenoid	Myxococcus xanthus
BGC0000513.3	0.13	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002487.3	0.85	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0002488.3	0.79	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0002490.2	0.59	other (other)	yersinopine	Yersinia pestis CO92
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000646.5	0.54	terpene	β-carotein	uncultured bacterium
BGC0002489.2	0.52	other (other)	pseudopaline	Pseudomonas aeruginosa PAO1
BGC0000645.3	0.49	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000648.3	0.47	terpene	carotenoid	Myxococcus xanthus
BGC0000664.5	0.44	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.43	terpene	isorenieratene	Streptomyces argillaceus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none

Genes with terpene domains:

CW747_RS07660: PT_phytoene_like

Domain 1 (4 - 287): Prenyltransferase; Phytoene synthase like

Subtype: Diapophytoene synthase

Reactions:: FPP → diapophytoene

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.35 out of 23.79

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

Additional weak hits (6):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.33 out of 32.93

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.55 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.31 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.51 out of 29.38

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.26 out of 20.01

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
IolR	Regulator of the inositol catabolism

NZ_PIZP01000004.1 - Region 2 - NRPS

Download region GenBank file

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Location: 206,676 - 251,004 nt. (total: 44,329 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CW747_RS08065: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CW747_RS08105: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase

CW747_RS08040: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

Hydrolases: hydrolase

CW747_RS07975: isochorismatase

smcogs: SMCOG1027: isochorismatase

CW747_RS08020: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: dehydratase

CW747_RS08015: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase

CW747_RS08055: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CW747_RS08060: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002164.2	0.63	NRPS	peramine	Epichloe festucae
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001249.5	0.62	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000342.4	0.62	NRPS	enniatin	Fusarium equiseti
BGC0002276.2	0.62	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001825.4	0.61	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.61	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.61	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.61	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002164.2	0.63	NRPS	peramine	Epichloe festucae
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001249.5	0.62	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000342.4	0.62	NRPS	enniatin	Fusarium equiseti
BGC0002276.2	0.62	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001825.4	0.61	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.61	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.61	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.61	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.97 out of 20.97

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.91 out of 30.25

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.35 out of 25.88

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.55 out of 21.55

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.98 out of 18.16

Confidence: strong

Additional weak hits (4):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.75 out of 26.85

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.98 out of 36.53

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.78 out of 26.85

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.16 out of 20.47

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 4, location 206675 - 251004:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CW747_RS08060: X

AMP-binding (449..852): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NRRMFDPSIWEGVFLVGGETNVYGPTETTIDVTN
Nearest Stachelhaus code(s):: ohdmTyr DPWGLGLIDK (62% 8Å match); ohmeTyr DPWGLGLIDK (59% 8Å match)
Stachelhaus code match:: 80% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
ArcA	Repressor of carbon oxidation
CcpA	Catabolite control protein A
ColR	Phenol-responsive regulator
PsrA	Oleic acid responsive regulator
ToxT	Regulator of MSHA biosynthesis

NZ_PIZP01000004.1 - Region 3 - lanthipeptide-class-iii

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Location: 255,599 - 278,157 nt. (total: 22,559 nt) Show pHMM detection rules used

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000519.4	0.50	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0002700.2	0.49	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000551.5	0.48	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000501.3	0.48	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0002111.3	0.47	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000496.5	0.46	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.3	0.45	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000553.3	0.45	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000486.4	0.40	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000519.4	0.50	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0002700.2	0.49	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000551.5	0.48	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000501.3	0.48	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0002111.3	0.47	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000496.5	0.46	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.3	0.45	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000553.3	0.45	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000486.4	0.40	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CW747_RS08200

CW747_RS14930

Leader:

MKQVLDLQQMRSKSGKK

Core:

KPSPKQSSASWGCAPSSNTSWFFC

Core with dehydrations:

KPDhaPKQDhaDhaADhaWGCysAPDhaDhaNDhbDhaWFFCys

antiSMASH-DB 4.0 matches for CW747_RS14930

100.0%

NZ_PIZP01000004.1:

Lanthipeptides: CW747_RS14930_lanthipeptide

1

KPSPKQSSASWGCAPSSNTSWFFC

24

KPSPKQSSASWGCAPSSNTSWFFC

1

KPSPKQSSASWGCAPSSNTSWFFC

24

62.5%

NZ_CP026031.1and 4 others:

NZ_CP026033.1 Lanthipeptides: C2H98_RS25970_lanthipeptideNZ_CP026040.1 Lanthipeptides: C2I17_RS08935_lanthipeptideNZ_CP053315.1 Lanthipeptides: HLK66_RS26225_lanthipeptideNZ_CP053989.1 Lanthipeptides: FOC77_RS25275_lanthipeptide

Lanthipeptides: C2I06_RS25335_lanthipeptide

7

SSASWGCAPSSNTSWFFC

24

SS S GC+PSSNTSWFFC

1

SSVSLGCSPSSNTSWFFC

18

58.3%

NZ_CP024036.1:

Lanthipeptides: CR091_RS27895_lanthipeptide

6

QSSASWGCAPSSNTSWFFC

24

SS S GC+PSSNTSWF C

1

NSSLSLGCSPSSNTSWFLC

19

with 5 more sequence matches

41.7%

NZ_JAMYIV010000006.1:

Lanthipeptides: allorf_139780_139899_lanthipeptide

6

QSSASWGCAPSSNTSWFFC

24

+SSAS C S S FFC

2

KSSASINCKRKSTLSLFFC

20

37.5%

NZ_JACDUR010000006.1:

Lanthipeptides: HNR30_RS28255_lanthipeptide

1

KPSPKQSSASWGCAPSSNTSWFFC

24

+P + +WGC TSW FC

1

RPPATEGWDTWGCC---KTSWSFC

21

33.3%

NZ_CP084585.1:

Lanthipeptides: allorf_0614669_0614794_lanthipeptide

7

SSASWGCAPSSNTSWFFC

24

++++W C S TSWF C

4

TTSNWLCY--STTSWFLC

19

15.6%

NZ_JANYMP010000042.1:

Lanthipeptides: allorf_39377_39523_lanthipeptide

6

QSSASWGCAPSSN

18

+S+ WGC P ++

3

RSAGMWGCYPHAH

15

15.4%

NZ_JAELVF020000001.1:

Lanthipeptides: allorf_1254884_1255084_lanthipeptide

6

QSSASWGCAPSSN

18

+ + WGCAP S+

5

EHAGRWGCAPPSS

17

CW747_RS14810

Leader:

MEKNNVLKLQSMRSKKSSNHQAS

Core:

NASVMCKKQSSASIIFCVFPGGK

Core with dehydrations:

NADhaVMCysKKQDhaDhaADhaIIFCysVFPGGK

antiSMASH-DB 4.0 matches for CW747_RS14810

100.0%

NZ_PIZP01000004.1:

Lanthipeptides: CW747_RS14810_lanthipeptide

1

NASVMCKKQSSASIIFCVFPGGK

23

NASVMCKKQSSASIIFCVFPGGK

1

NASVMCKKQSSASIIFCVFPGGK

23

43.5%

NZ_CP017429.1:

Lanthipeptides: BI282_RS13940_lanthipeptide

3

SVMCKKQSSASIIFCVF

19

S+ CKK+SS S CVF

2

SIACKKKSSISAFSCVF

18

39.1%

NZ_AXVK01000021.1:

Lanthipeptides: K332_RS24275_lanthipeptide

1

NASVMCKKQSSASIIFCV

18

N S +CKK+S+ S+ CV

2

NLSFVCKKESTLSLFLCV

19

with 14 more sequence matches

Only the first 10 are displayed here.

37.5%

NZ_MJGO01000037.1:

Lanthipeptides: BIU97_RS08315_lanthipeptide

1

NASVMCKKQSSASIIFC-VFPGGK

23

N S++CK+QSS SI C P G+

6

NLSLICKQQSSLSIYMCPTSPNGE

29

34.8%

NZ_JAMYIV010000006.1:

Lanthipeptides: allorf_139780_139899_lanthipeptide

1

NASVMCKKQSSASIIFC

17

+AS+ CK++S+ S+ FC

4

SASINCKRKSTLSLFFC

20

30.4%

NZ_FNVO01000002.1and 2 others:

NZ_FNVO01000002.1 Lanthipeptides: C4U03_RS04695_lanthipeptideNZ_FNVO01000002.1 Lanthipeptides: C4U03_RS04695_lanthipeptide

Lanthipeptides: C4U03_RS04695_lanthipeptide

4

VMCKKQSSASIIFCV

18

++C K SS S I C+

5

LLCDKHSSHSTILCL

19

30.4%

NZ_JAEVFI010000019.1:

Lanthipeptides: JJV70_RS15420_lanthipeptide

4

VMCKKQSSASIIFCV

18

++C K S AS I C+

5

LICDKHSGASTILCL

19

29.6%

NZ_CP012752.1:

Lanthipeptides: allorf_08741123_08741263_lanthipeptide

5

MCKKQSSASIIFC

17

+C K SSAS+I C

14

LCTKPSSASLILC

26

26.1%

NC_016582.1and 1 other:

NZ_FOLM01000007.1 Lanthipeptides: BM242_RS14445_lanthipeptide

Lanthipeptides: SBI_RS53340_lanthipeptide

4

VMCKKQSSASIIFCV

18

++C K SS S + C+

9

LLCDKHSSHSNLLCL

23

26.1%

NZ_AUBE01000003.1:

Lanthipeptides: G412_RS38950_lanthipeptide

4

VMCKKQSSASIIFCV

18

+ C K SS S + C+

6

LACDKHSSNSFLLCL

20

26.1%

NZ_BBQG01000022.1and 5 others:

NZ_CP048875.1 Lanthipeptides: G3260_RS30690_lanthipeptideNZ_CP050693.1 Lanthipeptides: HC362_RS03880_lanthipeptideNZ_CP103060.1 Lanthipeptides: NR995_RS03375_lanthipeptideNZ_KE150472.1 Lanthipeptides: HMPREF1486_RS35560_lanthipeptideNZ_VJOK01000001.1 Lanthipeptides: FM076_RS28910_lanthipeptide

Lanthipeptides: TU22_RS34220_lanthipeptide

4

VMCKKQSSASIIFCV

18

++C K SS S + C+

6

LLCDKHSSHSTLLCL

20

26.1%

NZ_CP021121.1and 1 other:

NZ_CP084541.1 Lanthipeptides: LC193_RS06630_lanthipeptide

Lanthipeptides: CAG99_RS21195_lanthipeptide

4

VMCKKQSSASIIFCV

18

++C SS S+I C+

9

LICDTHSSNSVILCL

23

26.1%

NZ_CP032402.1and 1 other:

NZ_CP032402.1 Lanthipeptides: D3U04_RS17070_lanthipeptide

Lanthipeptides: D3U04_RS17070_lanthipeptide

4

VMCKKQSSASIIFCV

18

++C K SS S + C+

5

LLCDKHSSQSTVLCL

19

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.35 out of 20.97

Confidence: strong

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.71 out of 33.14

Confidence: medium

Additional weak hits (4):

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.77 out of 27.18

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 19.26 out of 32.38

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.42 out of 32.93

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 21.77 out of 32.38

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

CW747_RS14930 - Class III

Cleavage pHMM score: -2.60

RODEO score: 0

Monoisotopic mass: 2445.1 Da

Molecular weight: 2446.7 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2464.7 Da N = 1; 2482.7 Da N = 2; 2500.7 Da N = 3; 2518.8 Da N = 4; 2536.8 Da N = 5; 2554.8 Da N = 6

CW747_RS14810 - Class III

Cleavage pHMM score: -3.10

RODEO score: 0

Monoisotopic mass: 2329.2 Da

Molecular weight: 2330.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2348.8 Da N = 1; 2366.8 Da N = 2

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
ZuR variant 2	Zinc-responsive repressor

NZ_PIZP01000006.1 - Region 1 - NRPS

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Location: 123,274 - 180,070 nt. (total: 56,797 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

CW747_RS10355: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

CW747_RS10520: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: PPTase

CW747_RS10450: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase

CW747_RS10445: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase

CW747_RS10455: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.73	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.72	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.69	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000308.5	0.68	NRPS	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0000307.4	0.68	NRPS	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.73	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.72	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.69	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000308.5	0.68	NRPS	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0000307.4	0.68	NRPS	AbT1	Aureobasidium pullulans

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.52 out of 28.14

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.44 out of 26.06

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.91 out of 23.79

Confidence: medium

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.39 out of 33.14

Confidence: medium

Additional weak hits (5):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.97 out of 32.74

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.10 out of 31.73

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.12 out of 36.54

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 19.87 out of 29.72

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.20 out of 29.38

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 123273 - 180070:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser - Ser - Ser - Ala - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CW747_RS10455: Ser - Ser - Ser - Ala - X

Search NORINE for peptide: strict or relaxed

AMP-binding (450..853): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWLTFDVSVWEGHFLASGEINLYGPTEATIDVTS
Nearest Stachelhaus code(s):: Ser DVWHLSLIDK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1488..1891): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWVTFDVSVWEGHFLASGEINLYGPTEATIDVTS
Nearest Stachelhaus code(s):: Ser DVWHLSLIDK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2526..2929): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSIWEGHFFTSGEYNLYGPTETTVEVTY
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (3565..3968): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEGHFLASGEIDLYGPTEASIEVIY
Nearest Stachelhaus code(s):: Ala DVWHLSLIEK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4603..5006): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEGHFLATGEIDLYGPTEASIEVTY
Nearest Stachelhaus code(s):: Ala DVWHLSLIEK (74% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
PerR	Peroxide regulator
ZuR variant 2	Zinc-responsive repressor

NZ_PIZP01000008.1 - Region 1 - NI-siderophore

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Location: 1 - 32,537 nt. (total: 32,537 nt) Show pHMM detection rules used

Region on contig edge.

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

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regulatory genes

other genes

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Gene details

Select a gene to view the details available for it

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KnownClusterBlast

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TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CW747_RS10810: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

CW747_RS10815: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000944.5	0.81	other (non-nrp siderophore)	staphyloferrin A	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.3	0.57	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000947.5	0.54	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0002073.3	0.53	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002682.2	0.52	other (other)	aerobactin	Vibrio mimicus
BGC0000939.5	0.50	other (other)	aerobactin	Grimontia hollisae
BGC0000943.5	0.47	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002683.2	0.45	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0002681.3	0.41	other (other)	rhizoferrin	Francisella tularensis subsp. tularensis SCHU S4
BGC0000617.5	0.40	ribosomal	coagulin	Bacillus coagulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000944.5	0.81	other (non-nrp siderophore)	staphyloferrin A	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.3	0.57	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000947.5	0.54	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0002073.3	0.53	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002682.2	0.52	other (other)	aerobactin	Vibrio mimicus
BGC0000939.5	0.50	other (other)	aerobactin	Grimontia hollisae
BGC0000943.5	0.47	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002683.2	0.45	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0002681.3	0.41	other (other)	rhizoferrin	Francisella tularensis subsp. tularensis SCHU S4
BGC0000617.5	0.40	ribosomal	coagulin	Bacillus coagulans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.55 out of 21.55

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.81 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.57 out of 29.38

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.53 out of 20.97

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.94 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.84 out of 29.38

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.42 out of 24.78

Confidence: strong

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.55 out of 25.88

Confidence: medium

Additional weak hits (7):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 19.79 out of 30.22

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.24 out of 33.14

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.48 out of 19.52

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.48 out of 29.65

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 21.53 out of 32.38

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.13 out of 23.43

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.50 out of 28.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CcpA	Catabolite control protein A
FuR variant 1	Ferric Uptake Regulator
LexA variant 2	Repressor of DNA damage response
PsrA	Oleic acid responsive regulator

NZ_PIZP01000009.1 - Region 1 - cyclic-lactone-autoinducer

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Location: 18,930 - 39,639 nt. (total: 20,710 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: kinase

CW747_RS11640: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Lyases: hydratase

CW747_RS11665: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001687.3	0.43	other (other)	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0002667.2	0.43	ribosomal	estericin A	Clostridium estertheticum
BGC0002579.2	0.39	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000540.5	0.36	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0000624.3	0.35	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000207.5	0.32	PKS	chartreusin	Streptomyces chartreusis
BGC0001872.3	0.32	PKS	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0001835.2	0.29	PKS	gynuellalide	Gynuella sunshinyii YC6258
BGC0001053.5	0.29	NRPS, PKS	tubulysin A	Archangium disciforme
BGC0000082.5	0.26	PKS	kijanimicin	Actinomadura kijaniata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001687.3	0.43	other (other)	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0002667.2	0.43	ribosomal	estericin A	Clostridium estertheticum
BGC0002579.2	0.39	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000540.5	0.36	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0000624.3	0.35	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000207.5	0.32	PKS	chartreusin	Streptomyces chartreusis
BGC0001872.3	0.32	PKS	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0001835.2	0.29	PKS	gynuellalide	Gynuella sunshinyii YC6258
BGC0001053.5	0.29	NRPS, PKS	tubulysin A	Archangium disciforme
BGC0000082.5	0.26	PKS	kijanimicin	Actinomadura kijaniata

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.10 out of 18.16

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 21.55

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14

Confidence: medium

Additional weak hits (3):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.71 out of 30.97

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.72 out of 30.11

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.24 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
ArcA	Repressor of carbon oxidation
PerR	Peroxide regulator
ToxT	Regulator of MSHA biosynthesis