LOCUS       NZ_PIZP01000009        20710 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Staphylococcus shinii strain INIFAP 005-08 NODE_9, whole genome
            shotgun sequence.
ACCESSION   NZ_PIZP01000009
VERSION     NZ_PIZP01000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Staphylococcus shinii
  ORGANISM  Staphylococcus shinii
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 112569)
  AUTHORS   Lopez,G. and Munoz,A.
  TITLE     Phylogenomics unveils the most efficient molecular markers for the
            species phylogeny - the case of the genus Staphylococcus
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 112569)
  AUTHORS   Grana-Miraglia,L., Miranda-Mirand,E., Arreguin,C., Cossio-Bayugar,R.
            and Castillo-Ramirez,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-DEC-2017) CCG, UNAM, Av. Universidad, Cuernavaca,
            Morelos 62210, Mexico
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-FEB-2017
            Assembly Method                   :: Spades v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 337.1969x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002836835.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 11:05:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,976
            CDSs (total)                      :: 2,900
            Genes (coding)                    :: 2,859
            CDSs (with protein)               :: 2,859
            Genes (RNA)                       :: 76
            rRNAs                             :: 7, 4, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 3 (5S, 16S)
            tRNAs                             :: 60
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 41
            CDSs (without protein)            :: 41
            Pseudo Genes (ambiguous residues) :: 0 of 41
            Pseudo Genes (frameshifted)       :: 22 of 41
            Pseudo Genes (incomplete)         :: 25 of 41
            Pseudo Genes (internal stop)      :: 13 of 41
            Pseudo Genes (multiple problems)  :: 13 of 41
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:11:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 18929
            Orig. end                         :: 39639
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            PIZP01000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20710
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..20710
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20710
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10710](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10710)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     misc_feature    37..46
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 15.1"
                     /tool="antismash"
     misc_feature    complement(735..750)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 23.71"
                     /tool="antismash"
     misc_feature    818..827
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            1482..2129
                     /locus_tag="CW747_RS11610"
                     /old_locus_tag="CW747_11605"
     CDS             1482..2129
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002482775.1"
                     /locus_tag="CW747_RS11610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11605"
                     /product="redox-sensing transcriptional repressor Rex"
                     /protein_id="WP_172643908.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 6.1e-09, bitscore:
                     29.5, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILANQSEKIPRATLKRLPLYYRFVNTLKSKGIDRVNSKAISEGL
                     NIDSATIRRDFSYFGELGKKGYGYNIDSLLHFFKNEISENDEIKIAIVGVGNLGKALLT
                     YNFSIHDEMTITEAFDIREEIIGTQIGKVTVSPFDKIKEILSQEDIDVVILTTPEEAAQ
                     NVADVLVDSGVKGILNFTPSRVLTPSDVQVHHIDLGIELQSLLFFMKNYSNK"
     gene            2347..3435
                     /locus_tag="CW747_RS11615"
                     /old_locus_tag="CW747_11610"
     CDS             2347..3435
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017723426.1"
                     /locus_tag="CW747_RS11615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11610"
                     /product="YeeE/YedE family protein"
                     /protein_id="WP_101051183.1"
                     /transl_table=11
                     /translation="MTWLIISGIIVGSLLGFVMQRTRFCLAGGFRDMYIQKSNKMFYAL
                     LIAISVQSIGLLILTSTGLVQIPESTYPVIGTVIGSFIFGLGIILAGGCATGTWYRAGE
                     GLIGSWMALIAYAFTSAATKYGLLLPLMDGVNKPTNVNTSMSQTTGIPTWVWVLFLTAI
                     TVFFVVKTLRKPKPKFAVPKLKQKFTGVRHYLFEKKYHPFVAAIAVGIIALIAWPVSES
                     TGRMYGLGITTPSANLVQFFVTGDLKLLDWGVFLVLGIFLGSYIAAKGAREFKWRLPDK
                     KTIRNSIIGGVFMGFGASVAGGCSIGNGLVETATMSWKGWIALASMILGAWTMSYFVFI
                     RPMKKAQKQTSNETATSQTQTI"
     gene            3457..3681
                     /locus_tag="CW747_RS11620"
                     /old_locus_tag="CW747_11615"
     CDS             3457..3681
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001830019.1"
                     /locus_tag="CW747_RS11620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11615"
                     /product="sulfurtransferase TusA family protein"
                     /protein_id="WP_002482777.1"
                     /transl_table=11
                     /translation="MVHELGTVGMVCPFPLIEAQKKMNTLDNGEELKIDFDCTQATEAL
                     PNWAAEQGYPVTNYEQLDDASWTITIQKA"
     gene            complement(4042..4227)
                     /locus_tag="CW747_RS11625"
                     /old_locus_tag="CW747_11620"
     CDS             complement(4042..4227)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017723428.1"
                     /locus_tag="CW747_RS11625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11620"
                     /product="hypothetical protein"
                     /protein_id="WP_101051185.1"
                     /transl_table=11
                     /translation="MDKGKQYTFITLIICIIVIVICLPFSLKNGSYSAIFSAFLPIIIL
                     IIASIFKAKDNNNDKD"
     gene            4423..5385
                     /locus_tag="CW747_RS11630"
                     /old_locus_tag="CW747_11625"
     CDS             4423..5385
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011302725.1"
                     /locus_tag="CW747_RS11630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11625"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_101051187.1"
                     /transl_table=11
                     /translation="MKNIADIAKIAGVSKSTVSRYLNNGSVSLKTKQKLDKIIRENDYQ
                     PNQFAQSLRAHRTNMIGAIIPRMNSFAVDETVKGVKTICDQLNYSLLLNYTNLNTQLEI
                     DALETFYRSKVDGIVFMATEITEQHLEVINKINVPVIIVGQAHDELHCIIHNDYQAGYL
                     VGDMLGQQGYKDIKFFGVTESDIAVGVQRKNGLVAGLEKHGIKPHISLTSFNYQEAMID
                     VVEALQAYPYYDAIVGATDSIALAIHKYNSEHVPHMHEKYIVGFGGDPVTEIVSPSIHT
                     VNYNFEYAGSVAMDKLNQMIQQQEVEQRIIIDVQHTFKN"
     misc_feature    complement(5416..5430)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 19.72"
                     /tool="antismash"
     gene            5470..6954
                     /locus_tag="CW747_RS11635"
                     /old_locus_tag="CW747_11630"
     CDS             5470..6954
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001613916.1"
                     /locus_tag="CW747_RS11635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11630"
                     /product="sucrose-6-phosphate hydrolase"
                     /protein_id="WP_039069568.1"
                     /transl_table=11
                     /translation="MTEWTKEQRYQRYEDVDQQTIETLTEQVNQSKYRQIFHIQPKIGL
                     LNDPNGLIYFKGNYYVSHQWFPLGPVHGLKYWYTYQSKDLVEFEAIGPTIKPDTKDDSH
                     GVYSGSAFEYHDHLYYMYTANHRDSDWNRISTQHIAKMAKDGSINKFPKAVISEPPFGY
                     TQHFRDPKVHVQNGVYYAMIAAQNIKKQGRILQYRSTDIVNWEFQGEIQTNLDDFGYMW
                     ECPDYFNLNGYDMLLFCPQGIDSEGERFKNIYQSGYIMGQYDINNLTMNHGDFHELDYG
                     FDFYAPQTFLDENDQRILIGWMGLPEINYPSDADGWAHCLTIPRVLTIESGNLKQRPIK
                     ALEKLRTNEETALGYANKFTRQLHPYEGKQFELIIDILENEATEVYFEVRTSKTESTLI
                     TYNKREQKLTLDRSESGQLPGPVEGTTRSTYLDTPLSKLQLFVDTSSVEIFCNDGERVM
                     TTRIFTDENATGIKTSTESGQTYLKFTKYDLKGDIK"
     gene            6951..7916
                     /locus_tag="CW747_RS11640"
                     /old_locus_tag="CW747_11635"
     CDS             6951..7916
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017723431.1"
                     /locus_tag="CW747_RS11640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11635"
                     /product="carbohydrate kinase"
                     /protein_id="WP_101051189.1"
                     /transl_table=11
                     /translation="MKRLLAIGEALIDFIPSTTDSKLKDVEMFSRQVGGAPCNVACTAT
                     KLGGNAEMITQLGQDAFGDLIVETLDNLGVGTQYLKRTNEANTALAFVSLTKEGERDFS
                     FYRKPSADMLYSIDAVSTIDVNENDVLHFCSVDLVESPMKYAHKKLIEKVTHAGGTIVF
                     DPNVRLPLWKNEADCKSAIHEFIPLAHIVKISDEELEFVTGITDENQAIQWLFQGNVDA
                     VIYTKGADGATVYFKDGNEISQQGFKVKAIDTTGAGDAFIGALISKLLISDSTDLIAVL
                     KNEGKAILEFSNYVAATVTTKYGAISSIPTLEEVNKAIKS"
     gene            complement(7950..8666)
                     /locus_tag="CW747_RS11645"
                     /old_locus_tag="CW747_11640"
     CDS             complement(7950..8666)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000688500.1"
                     /locus_tag="CW747_RS11645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11640"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_039069566.1"
                     /transl_table=11
                     /translation="MKIFICEDDERQREHMVSIINNYIMIEEKPMEIEVATADPYDILE
                     RSKNINDIGCYFLDIQLEADINGIKLASEIRKHDPVGNIIFVTSHSELTYLTFVYKVAA
                     MDFIFKDDPDELKSRVIDCIETSESRLKLLSKESSVETIELKRGSNSIYVQYDDVMFFE
                     SSSKSHRLIAHLDNRQIEFYGNLKEIDQLDKRFFRCHNSFVVNRHNIESIDSKSRIVYF
                     KNNEHCYASVRNVKKI"
     gene            complement(8679..9719)
                     /locus_tag="CW747_RS11650"
                     /old_locus_tag="CW747_11645"
     CDS             complement(8679..9719)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011302728.1"
                     /locus_tag="CW747_RS11650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11645"
                     /product="GHKL domain-containing protein"
                     /protein_id="WP_338061916.1"
                     /transl_table=11
                     /translation="MYISNFVTIWLIITILDYNTSSVTFQLYYAGTFVIIYIISMYIIH
                     YFLTRLNKSVLSFNKVYLITVSLFLITAILLLNIYLPKSTVSFKDVKFLSLIFSVFIIT
                     IAILIITISFSVIRQIQYKRNMQEIENYYKYTLQIEKINHEMRKFRHDYVNILSTLSDF
                     IREEDMEGLRDYFHSEILPMQDSMQMNAIKINGIENLHVREIKGLLTTKILQAQEKNIR
                     ISIEVPEPIEKIDMPIINLSRVIGILLDNAIEASEKITEDPLIRIAFIKNEDTSVTFIV
                     MNKCEPDMPKVHTLFQENFSTKGKNRGLGLSTLKELTDSTTNVLLDTTIDNNYFIQKVE
                     ILNSDS"
     misc_feature    complement(9686..9703)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.27"
                     /tool="antismash"
     misc_feature    9828..9844
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 25.24"
                     /tool="antismash"
     gene            complement(10001..10138)
                     /locus_tag="CW747_RS11655"
                     /old_locus_tag="CW747_11650"
     CDS             complement(10001..10138)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002507141.1"
                     /locus_tag="CW747_RS11655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11650"
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="WP_069793020.1"
                     /sec_met_domain="TIGR04223 (E-value: 6.2e-08, bitscore:
                     25.5, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFLLDSIFKIIAKFFTVIGVASGGHVCIGFADEIEVPKEITDLYE
                     "
     gene            complement(10141..10710)
                     /locus_tag="CW747_RS11660"
                     /old_locus_tag="CW747_11655"
     CDS             complement(10141..10710)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002507142.1"
                     /locus_tag="CW747_RS11660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11655"
                     /product="accessory gene regulator AgrB"
                     /protein_id="WP_101051191.1"
                     /sec_met_domain="AgrB (E-value: 4.1e-32, bitscore: 103.8,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKLIDTKIDNFAKSLQLRNNLDHIEYLKMRLGMQVVVNNFFKTT
                     IIYGVSILCHLFLYTLTVHLSFLLIRVSAHGAHATSSLFCYIQSLVIFVLLPAIIGYYQ
                     VSSVLLYPLAIIGFIILATFAPTATKKQPIPERLKKSKKIKTIISTALLLLLSLFFETP
                     YQQFILIGIVIVSCYQLPTILLKEDV"
     gene            complement(11471..12256)
                     /locus_tag="CW747_RS11665"
                     /old_locus_tag="CW747_11660"
     CDS             complement(11471..12256)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002461414.1"
                     /locus_tag="CW747_RS11665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11660"
                     /product="carbon-nitrogen family hydrolase"
                     /protein_id="WP_039069562.1"
                     /transl_table=11
                     /translation="MNIEVFQFKIEPANVSLNEENIVNWFSKFVTSETDVVVLPEMWNN
                     GYALPQLKELADTQLSRSYEFISKLAIQYDVDIIAGSVSNSMKEDVYNTAFAVSKNGYL
                     INSYDKVHLVPMLDEPSFLTAGNAVPEAFNLTNGVKATQIICYDLRFPELLRYPARKDA
                     EIAFYVAQWPQARVSHWIALLKARAIENDMFVVGCNACGDDGQTEYAGHSIVINPNGEI
                     VAQLEDKPDHISCGINLDEVSNQRENIPVFKNLRPHLYK"
     gene            complement(12604..13233)
                     /locus_tag="CW747_RS11670"
                     /old_locus_tag="CW747_11665"
     CDS             complement(12604..13233)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522387.1"
                     /locus_tag="CW747_RS11670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11665"
                     /product="nitroreductase family protein"
                     /protein_id="WP_101051193.1"
                     /sec_met_domain="PF00881 (E-value: 9.1e-19, bitscore: 60.9,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLFSKKDSTLETFQNAIEKRRTIYSLDQDISISDNEVEDIIEHA
                     IKHVPSSFNSQSTRIVLLLNDNHNKFWEITKQELKNAMGPDRDFQATSDKVDNFKHSHG
                     TILFFEDQDVIEGLQNQMPNYAENFAVWSSQTNAMHQFSIWTALSTVGIGASLQHYNPL
                     VDVAVSEAFEIPKTWKLVAQMPFGNIRDEAGDKEFHDTSKRFLVRK"
     misc_feature    complement(13273..13286)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 24.68"
                     /tool="antismash"
     gene            13428..15338
                     /locus_tag="CW747_RS11675"
                     /old_locus_tag="CW747_11670"
     CDS             13428..15338
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039170.1"
                     /locus_tag="CW747_RS11675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11670"
                     /product="SdrH family protein"
                     /protein_id="WP_101051195.1"
                     /transl_table=11
                     /translation="MKWYFSHKFVISSFALALSTTLVSSQTHAAEQQIDEKLTNNNTNQ
                     SDKRPIHSNPANHIKSPTTVEDTVQSDNTTNQESDNDLGETVQDNEKIQNDWDKQNTNN
                     DELSDVQGQQDNSNLIEQNQSNNDNSNEMNEQPNPDESNNGDGTDDQPNPDEPNNGDGT
                     DEQPNPDESNNGDGTDEQSNPDEPNNGDRTDEQPNPDEPNNGDGTDEQPNPDEPNNGDG
                     TDEQPNPDEPNNGDGTDEQPNPDEPNNGDGTDEQPNPDEPNNGDGTDEQPNPDEPNNGD
                     GTDEQPNPDEPNNGDGTDEQPNPDEPNNGDGTDKPSGGGSETPDKPGNGDNGNTQPNPD
                     EPNNGSGSDKPSGGGSETPKPPNEDSDTNKPNNGNHAGPNNSNKPGNNSNLSPSKPNNQ
                     GDSNVTSNQGGNTNNNSNTNNHSINHANDNNNELQYGSSSHHEIASGGVSASYGDLAKN
                     EKSQSNEKQLINRFDQMSSGSFKYNPFVVNQVKQLGSSAKTVTDKDISSVLRRQTFADN
                     AFLNELQKGTNYFKFQYFNVLKSSDYYKNLDNQVLALITGEIGSMPDLKNPKRQQSSGK
                     YEYHSSSEDELTHTTNEQSKNEIDVKFERTLFALITAMIIIFIGMVLGFIVNRKNKKDS
                     E"
     gene            complement(15417..16160)
                     /locus_tag="CW747_RS11680"
                     /old_locus_tag="CW747_11675"
     CDS             complement(15417..16160)
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002507146.1"
                     /locus_tag="CW747_RS11680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11675"
                     /product="type II CAAX endopeptidase family protein"
                     /protein_id="WP_101051197.1"
                     /sec_met_domain="Abi (E-value: 2.4e-19, bitscore: 62.4,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLWVSILTLVIYGLAQFGIIILQLSGLFDHYSGKELVFAQIYT
                     QVILFIIASFIIIIINHFIANPTSLEQKPKEKKRYAIGWALVGYFVVMIYQIIANMINI
                     YLLGAPQSSPNTERLMKVAQEIPIFIVLISVVGPILEEFVFRKVIFGEIYNVIQANKTI
                     KFLIAGIVSSIIFSAAHSDPSFFIIYFGMGIIFSALYVYTKRIWVPILVHIMQNGFVVI
                     IQVLVGPEKIKEMQDSASFIFNFLF"
     gene            16339..16626
                     /gene="groES"
                     /locus_tag="CW747_RS11685"
                     /old_locus_tag="CW747_11680"
     CDS             16339..16626
                     /codon_start=1
                     /gene="groES"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002482789.1"
                     /locus_tag="CW747_RS11685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11680"
                     /product="co-chaperone GroES"
                     /protein_id="WP_029378932.1"
                     /transl_table=11
                     /translation="MLKPLGNRVIIQKSEQEQTTKSGIVLTDSAKEKSNEGTIIAVGAG
                     RILEDGSRVAPEVNEGDNVVFQQFAGTEVKRGDETYLIVNEEDILAIIES"
     gene            16690..18312
                     /gene="groL"
                     /locus_tag="CW747_RS11690"
                     /old_locus_tag="CW747_11685"
     CDS             16690..18312
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /gene="groL"
                     /gene_functions="other (smcogs) SMCOG1299: chaperonin
                     GroEL"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500736.1"
                     /locus_tag="CW747_RS11690"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES; misfolded
                     proteins enter the barrel where they are refolded when
                     GroES binds; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11685"
                     /product="chaperonin GroEL"
                     /protein_id="WP_039068958.1"
                     /transl_table=11
                     /translation="MAKDLKFSEDARQSMLRGVDKLANAVKVTIGPKGRNVVLDKEYTS
                     PLITNDGVTIAKEIELEDPYENMGAKLVQEVANKTNEIAGDGTTTATVLAQAMIQEGLK
                     NVTSGANPVGLRQGIDKAVEVAINALHDISQNVDNKNEIAQVGSISAADEEIGKYISEA
                     MEKVGNDGVITIEESSGFNTELEVVEGMQFDRGYQSPYMVTDSDKMVAELEKPYILITD
                     KKISSFQDILPLLEQVVQSNRPILIVADDVEGDALTNIVLNRMRGTFTAVAVKAPGFGD
                     RRKAMLEDLAILTGAQVITDDLGLDIKDATIDMLGTSNKAEITKDNTTVVDGDGDQNNI
                     DARVSQIKAQIEETDSEFDKEKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALN
                     STRAAVEEGIVAGGGTAFMNIYEKVSKIEAEGDIATGINIVLKALEAPVRQIAENAGLE
                     GSIIVERLKNADVGVGFNAATNEWVNMLEAGIVDPTKVTRSSLQHAASVAAMFLTTEAV
                     VANIPEESSNDTQAGMGGMPGMM"
     gene            19130..19597
                     /locus_tag="CW747_RS11695"
                     /old_locus_tag="CW747_11690"
     CDS             19130..19597
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019835050.1"
                     /locus_tag="CW747_RS11695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_11690"
                     /product="DinB family protein"
                     /protein_id="WP_039068959.1"
                     /transl_table=11
                     /translation="MTKPTVYEVIDLGINYLISGYDNWSNAQVLDDKIAAFPNTIHWQY
                     GHVLTIFESALSLCEQNEVDIAKYTSLFGYGSSPEKWGDEDIPTVDEIFEHLKTLPNRA
                     RNLTDEQLEQELTETIAGCSTLNELLVLNAIHVPLHAGKIEEMSRILKQHQ"
ORIGIN
        1 cgttaattat ttttttaacg tcttcttgta caaatagaaa gcgacctaaa acagcacgaa
       61 tgtctttttc attcatagta gggtattggt cccataagta atcaagtatt gttttatttg
      121 atttgaattc ggcttgtttc tgatcataat aaccaatttt taagttagca ccggtagtga
      181 ttgatccatt taatgcattt tgtatattgg caatggtttt tattaaagtt gatttcccaa
      241 taccattagg accgataatt gcaatatgat ctccttttgt tacttcaaaa gtaatccctt
      301 tagtaatcgg agactcatag ccaatctcta aattttttat atggaataca tcattaccag
      361 tattacgatc aaattcaaat tgaatgttgg cacttttagc atcaatcata ggtttattaa
      421 tgcgttcaat tttttctaac attttcctac ggctcttagc catacctgta gttgaagcac
      481 gagcaatatt tttatcgaca aaagtctcta atcgtttaat ttcagcttgt tgactttcat
      541 attcttgcat acgtttttca taatatttgt ctctttgatc aataaactga gcataattgc
      601 ctacataatg ctgaacgtca ccgagtgcta cgtcataaat ttgagtcaca attttatcta
      661 agaagtacct atcatgactg ataattacaa tggcaccttt aaagtaattt aaataacttt
      721 ctaaccattg ggtcgtttcc atgtctaaat ggttggtggg ttcgtccaaa agtaataaat
      781 caggctcgct taataacatt tgtgccaaag ataaccttgt tttttgacca ccgctaaagt
      841 cattgatagg tcgatcaaaa tccgcttcac taaaatttag tccatgtaag actgttttaa
      901 ttttgctttc atattgatag ccatcttgtt gttcaaattg attggataat gcttcgtagc
      961 gatcgatatg agatttatat gtctcagtat cgtattcagt ggcatgttgt gctaaccaat
     1021 ctgtttccaa tttcatttct tgttctaaat ttttcattgc ttcaaacggt ttagacattt
     1081 cttcaaatac agtttggtct gtatttaatg tcatttgctg tgttaaataa ccaagtttta
     1141 aatttttact cttagaaata tgaccactat cataatcttc aacgccagca attattttca
     1201 ttaatgtaga ttttccggca ccattacggc ctacaatacc aatgcgttca ccagttttaa
     1261 cttcaaaatc cacattatta aaaatatctt caccgtcaaa tgatttagtt aaatcattga
     1321 gttgtaataa tatcatctga ttttgcacct ctctattcat tatcattcta cagtattcag
     1381 cgtgttgtta aaactatcat tgtttatttt tattattcag tcatgtataa tgttgtagtg
     1441 attataaaat taatgaataa cagataatga aataggggga catgatcttg gctaatcaaa
     1501 gcgaaaagat tcctcgtgcc acattgaaac gtttaccgtt atattataga ttcgtcaata
     1561 cattaaaatc taaaggcatt gatagagtta attctaaagc catcagtgaa ggcttaaata
     1621 ttgattctgc aacgattcga agagattttt cttattttgg tgagttaggc aagaaaggct
     1681 atggctataa tattgatagt ttattacatt tctttaaaaa tgaaataagc gaaaatgacg
     1741 agattaaaat tgcaattgta ggtgtaggga acttaggtaa agcattattg acatataact
     1801 tttcaataca tgatgaaatg actataactg aagcatttga tattcgcgaa gaaattattg
     1861 ggacacaaat aggtaaagtg acagtgagtc catttgataa aataaaagaa atattatcac
     1921 aagaagatat cgatgtagtg atattgacta caccagaaga agcagctcaa aatgtagctg
     1981 atgtgttagt agattcaggt gttaaaggga tacttaattt tacaccaagt cgtgtactaa
     2041 caccttcaga tgttcaagtg catcatattg acttaggtat cgaattacaa tctttattat
     2101 tctttatgaa aaattatagt aataaataag aaataattta gtcagttttt tatagataca
     2161 gtaatacact ttgtgtgctg tgtttataaa aaactatttt tttatgaatt tttaattaga
     2221 atttcaacat actctactta ttaagttagt tgaagtttaa aaaatttatg agttacaagg
     2281 ttgaaatttt atacgatttc taatattatt aatcttattg attttatcgg gaaagaggtt
     2341 attaatatga cttggttaat aatcagcggc attattgtgg gcagtctttt aggctttgtt
     2401 atgcaaagga cacggttttg tctagctggc ggttttagag atatgtatat tcaaaagagt
     2461 aacaaaatgt tttatgcatt acttatagca atttcagtac aaagtatagg gttattaatt
     2521 ttaacttcta ctggtttagt acaaatacct gaatcgactt atcctgttat tggaacggta
     2581 ataggttcgt ttatttttgg tttaggtatt atattagctg gtggatgtgc gactggtaca
     2641 tggtatagag ctggtgaagg tttaattggt agttggatgg cacttattgc ttatgcattt
     2701 acatcggcag ctacaaaata tggtttgttg ttaccgttaa tggatggtgt taataagcct
     2761 accaatgtta atacgagtat gtcacaaact actgggatac cgacatgggt ttgggtacta
     2821 ttccttacag ctataacagt atttttcgta gtcaaaacat tacgtaaacc gaaacctaaa
     2881 tttgctgttc ctaaattaaa acagaaattt acgggcgtac gtcactattt atttgaaaag
     2941 aaataccatc cattcgttgc tgcaatagca gtaggcatca ttgcattaat tgcatggcct
     3001 gtaagtgaat cgacaggaag aatgtatggg cttggaatta ctactccatc tgccaatcta
     3061 gtacaatttt ttgtaactgg tgatttgaaa ttattagact ggggtgtgtt cttagtcctt
     3121 ggaatattcc taggatctta tattgccgct aaaggtgcaa gagagtttaa atggagatta
     3181 ccagacaaga aaactatccg taatagtatc atcggtggtg tgtttatggg attcggtgct
     3241 tcagtggcag gtggttgttc aatcggtaat ggactagtag aaacagcaac gatgtcgtgg
     3301 aagggttgga ttgcactcgc ttcaatgata ttaggcgctt ggacaatgag ttattttgta
     3361 tttattagac ctatgaaaaa agcacaaaag caaacttcta atgaaacggc aacgtcacaa
     3421 acacaaacaa tataattaat ataggaggca caaattttgg tacatgaatt aggtacagta
     3481 ggaatggtat gtccattccc attaatagaa gcacaaaaga aaatgaatac gctagataat
     3541 ggtgaagaat taaaaataga ttttgattgt actcaagcaa ctgaagcatt accaaattgg
     3601 gcggctgagc aaggctatcc agttacaaat tatgaacagt tagatgatgc atcatggaca
     3661 atcacaattc aaaaagctta attaagagta atagctgaga ttgacattgc aagtgaactt
     3721 cacttattca attagacaac aggataatta aaataaaaat ggtcgaattc ctagctatgc
     3781 tttgagttcg atcattttta tttatttata tattttttag tcagaatttt gttttttaat
     3841 atttgaatta atacatagat tccaattatt aacattatta ttggtagtat catgaccaaa
     3901 taaataaaaa accttcagag atattaatag ttaacgctaa cattaaaaca atgagtaaaa
     3961 ataaatttaa tagatttaac cttacagttc ttgtcatgtt ttcctccatt aaactaaata
     4021 agtatataat caataaccct gttaatcttt atcattatta ttgtctttag ctttaaagat
     4081 agaggcaata attaatataa ttataggaag aaaagctgaa aaaatggctg agtaactacc
     4141 atttttaagt gaaaatggta aacaaataac gatcactatt atgcaaataa ttaatgttat
     4201 aaaggtgtac tgtttccctt tatccatgac atatctctcc ttaaagttgt tatttccaca
     4261 actatatcat attgaaaact caacttatat gttacttatt tagagacact aatagtaagt
     4321 tttaaccttt ctataaacgt agatttaaat agtatttaaa gcgattgcat tatgataaaa
     4381 taagtattgt ttataatagc taattaatga gagtgagaaa atatgaagaa cattgctgat
     4441 atagctaaaa tcgctggcgt ttcaaaaagc acagtgtcga gatacttaaa taatggttcg
     4501 gtaagtttaa aaacaaaaca aaagctagat aagatcattc gagaaaatga ttatcaacct
     4561 aatcaatttg cgcaaagttt acgagcacat agaactaata tgataggggc aattatacct
     4621 agaatgaact cttttgctgt cgacgaaaca gttaaaggag tcaaaacgat ttgtgatcaa
     4681 ttgaattata gtttgctact aaattacaca aatcttaata ctcaattaga aattgatgcg
     4741 cttgaaacat tttatagaag taaagtagat ggtattgtct ttatggcaac agaaatcaca
     4801 gagcaacatt tagaagttat taataaaata aatgttcctg tgattattgt tggtcaagca
     4861 catgatgagt tacattgtat cattcataat gattaccaag cgggatactt ggttggcgat
     4921 atgttaggtc aacaaggtta taaagatatt aagtttttcg gtgtgacaga aagtgatatt
     4981 gctgtaggtg ttcaacgtaa aaatgggcta gttgcaggtt tagaaaaaca tggtataaaa
     5041 ccacacattt cacttacatc ttttaattat caagaggcga tgatagatgt tgtagaagca
     5101 ttacaagctt atccctatta tgatgcaata gttggagcta cagattcaat tgccttagct
     5161 atacataaat ataattcaga acatgtgccg catatgcacg agaaatatat tgtaggattt
     5221 ggtggagacc cagtaactga aatcgtgtca ccgtctattc atactgtaaa ttacaatttt
     5281 gaatatgcag gtagtgttgc tatggacaaa ctaaaccaga tgatacaaca gcaagaagtt
     5341 gaacaacgca tcattattga tgttcaacat acatttaaaa actaactcaa aagtgttatg
     5401 attaaaaagt atattatgga accggtacca ttttaatgta attattttta aaataggagg
     5461 atacgcacta tgacggagtg gacaaaagag caacgttatc aaagatatga agatgttgat
     5521 caacaaacga ttgaaacatt aactgaacaa gtcaatcagt caaaatatag acaaattttt
     5581 catatacaac ccaaaatagg attgttaaat gatcctaatg ggcttatcta tttcaaggga
     5641 aattattatg tctcacatca gtggttcccg ctaggtcctg tacatggact gaaatattgg
     5701 tatacatatc aaagtaaaga ccttgttgaa tttgaagcta ttgggccaac gattaaacca
     5761 gatacgaaag atgatagtca tggtgtatat agtggcagcg catttgaata tcatgaccat
     5821 ttatattata tgtatactgc taatcatcgt gacagcgact ggaatagaat ttccacacaa
     5881 catatagcaa aaatggctaa agatggctcg attaataaat ttcctaaagc agtaatatct
     5941 gaaccaccgt ttggctacac tcaacatttt agggatccta aggtacatgt tcaaaatgga
     6001 gtttattacg cgatgatagc tgcacaaaac ataaaaaaac aaggtagaat tttgcaatat
     6061 cgttcaacag atatcgtaaa ttgggagttt caaggagaaa tacaaacgaa tctagacgat
     6121 tttggttata tgtgggaatg cccagactat tttaatttaa acggctatga catgttactg
     6181 ttttgccctc aaggtattga ttcagaagga gaacgtttta agaatattta tcaatctggc
     6241 tatattatgg ggcagtatga tatcaataat ttaactatga atcatgggga ttttcatgaa
     6301 ttagattatg gttttgattt ttacgctcca cagacatttt tagatgaaaa tgatcaacgc
     6361 atattaattg gttggatggg tctgccagaa attaactatc cttcagatgc cgatggttgg
     6421 gcacattgtt taactattcc acgtgtgttg acaattgagt caggtaattt aaaacaacgt
     6481 ccgattaaag cacttgaaaa acttcgtaca aatgaagaaa cagcactagg ttacgctaat
     6541 aaatttacta gacaattaca tccatatgaa ggtaaacagt ttgaattaat tatcgatatt
     6601 ttagaaaatg aagcgacaga agtttatttt gaagtacgta cgtctaagac tgaatcaact
     6661 ttaattacgt ataataaaag ggagcagaaa ttaacattag accgtagtga aagtggtcaa
     6721 ttacctggac ctgttgaagg gacgacgaga agtacttatt tagatactcc gttatcaaaa
     6781 ctacagttat ttgtagatac ttctagcgtg gaaattttct gcaatgatgg ggaacgtgtg
     6841 atgacgacaa ggatatttac agatgaaaat gcgacaggca ttaaaacatc tactgaatca
     6901 ggccaaacct acctaaaatt cacaaaatat gatttgaaag gtgacattaa atgaaacgtt
     6961 tactagcaat tggagaggct ttaattgact ttataccaag tactacagat tctaaattaa
     7021 aagatgtaga aatgttttct cgtcaggttg gaggagcacc gtgcaatgtg gcctgtacag
     7081 caacaaaact aggcggaaat gctgaaatga ttacacaatt aggacaagat gcttttggtg
     7141 atttaattgt ggaaactcta gataacctag gtgtaggtac tcaatactta aaacgtacta
     7201 acgaagctaa cacagcttta gcgtttgtga gtttaactaa agagggggaa agagactttt
     7261 ctttttatag gaagccatcc gctgacatgt tatacagtat agatgcagta agcaccatcg
     7321 atgtaaatga aaatgatgta ttacatttct gttcagttga tttagtggaa agtcctatga
     7381 aatatgcaca taagaaattg attgagaaag tgacacatgc aggagggaca attgtatttg
     7441 atcctaatgt gaggttgccg ttatggaaaa atgaagcgga ttgtaaatca gcaatccatg
     7501 aatttattcc attagcacat attgtcaaaa tatctgatga agaattagag tttgtaacag
     7561 gaattacaga tgaaaaccag gctatacagt ggttgttcca aggtaacgtt gatgcagtaa
     7621 tttataccaa aggtgccgat ggtgcgaccg tatattttaa agacggaaat gaaatatctc
     7681 aacaaggatt taaagttaaa gccattgata ctacaggtgc gggtgacgca tttataggtg
     7741 ctttaattag taaattatta atttctgatt ctacagattt gatagcagta ttaaaaaatg
     7801 aaggtaaagc catacttgaa tttagtaatt atgtagctgc aacggttact acgaaatatg
     7861 gagcgatatc aagtattcca actttagaag aagtgaataa agcaataaaa agctgagcat
     7921 gtaattaaac atgcccagct ttttatgtat tatatctttt taacatttct tacagacgca
     7981 taacaatgtt cattgttttt gaaatagact atgcgcgatt tagagtcgat ggactcgata
     8041 ttgtgtctat taactacgaa actattatga cacctaaaga aacgtttatc taactgatcg
     8101 atttctttaa gatttccata gaattcgatt tgacgattat ctagatgtgc aattaaacga
     8161 tgggacttgc tagatgattc aaagaacatc acatcgtcgt attgtacata aatagaattg
     8221 ctaccacgtt ttaattctat tgtttcaaca ctgctttctt ttgagagtag ttttaaacgt
     8281 gactcagaag tttctatgca atcaatcact cttgatttta attcgtctgg atcatctttg
     8341 aaaataaagt ccattgcagc aaccttgtag acaaatgtta agtaagtcag ctcactgtga
     8401 cttgtaacaa aaatgatatt gccaaccggg tcatgcttgc gtatttcact tgcaagcttg
     8461 ataccattga tatcagcttc taattggata tctaaaaagt aacatcctat atcattaatg
     8521 ttctttgatc gttctaaaat gtcataagga tcagctgtcg caacttcaat ttccattggc
     8581 ttttcttcaa tcataatata attattaata attgatacca tatgttcacg ttgtctttcg
     8641 tcgtcttcac aaatgaatat tttcatagtt acacatcctt atgaatcaga atttaagatt
     8701 tccacttttt gaataaagta gttgttatca atagttgtat ctaataaaac atttgttgtt
     8761 gaatcagtca attcttttaa cgtggataac ccaagtccac ggtttttccc tttagtagaa
     8821 aagttttctt ggaaaagagt atgtacttta ggcatatctg gttcacactt gttcataacg
     8881 ataaatgtga cggatgtgtc ttcattttta ataaaagcaa tacgaataag tgggtcttca
     8941 gtaatctttt cagaagcttc aattgcgtta tcaagtaata taccgattac tctacttaaa
     9001 tttataatag gcatatcaat tttttcaatt ggttctggca cttcaatgct gatgcgaata
     9061 tttttttctt gggcttgaag tattttagta gttaacaaac ctttaatttc gcgaacatgc
     9121 aagttttcaa taccattgat tttaattgca ttcatttgca tactatcttg cattggtaat
     9181 atttcagaat gaaagtaatc tcttagacct tccatatctt cttccctgat aaaatctgag
     9241 agggtagata aaatattgac ataatcatgt ctaaatttac gcatttcatg attgattttt
     9301 tcaatttgta acgtgtattt ataataattt tcgatttctt gcatattacg cttatattga
     9361 atttgacgaa taacgctaaa agaaattgta attataagaa tagcgattgt aatgataaat
     9421 acagaaaata ttaaagataa aaatttaacg tctttaaaag aaactgtact cttaggtaaa
     9481 taaatattca ataataaaat tgcagttatt aaaaataatg aaacagtgat taagtacact
     9541 ttattaaaag acagaacaga tttattaagt ctagttaaaa agtagtgaat aatatacata
     9601 gaaataatat aaataataac aaaagttcca gcatagtata attgaaatgt aaccgaagaa
     9661 gtattgtaat ctaaaattgt aattattaac caaatagtaa caaaattaga tatatacaaa
     9721 ataaaacaac tacctagtac tgtaagaata cccaaaattt tgttttttac atatgcccaa
     9781 atagatacta ttattaatag tattaataat gtttgagagc cccaaacttg taacaaaaca
     9841 acattaagga taataaccac taataaaatg gttacatcct taattgtaaa atatatctta
     9901 ttaaagaatt taattgaaaa aattaataat aaaatttgaa ttataggtaa aacataaaga
     9961 ttcaaaaatg ccattttata cacactttct atactaacaa ttattcatac aagtcggtga
    10021 tttcttttgg aacttcaatt tcgtcagcaa agccaataca tacatgacca cctgatgcaa
    10081 cgcctattac tgtgaaaaac ttagcgataa ttttgaaaat agaatctaat aaaaacatat
    10141 ttaaacatcc tcctttagta aaattgtggg caattggtaa cacgacacaa taacaattcc
    10201 tattaatata aattgctggt atggtgtctc aaaaaacaag gataaaagta ataacaaggc
    10261 tgtacttatt attgttttaa ttttcttgct ttttttcaat cgttcaggaa tcggttgttt
    10321 ttttgtagct gtcggagcaa atgttgctag gataataaat ccaataattg ctaatggata
    10381 tagtaatact gatgatactt gataataccc aataatagca ggcaataaaa caaatattac
    10441 taaactttga atataacaaa ataatgagct tgtagcatgt gctccatgag cagagacacg
    10501 aattagaaga aatgataaat gaacagttag tgtgtataag aataaatggc aaaggattga
    10561 aacaccataa atgatagttg ttttaaagaa attatttact acaacttgca tgcctaaacg
    10621 catctttaaa tattcgatat gatctaaatt gttgcgtaat tgtagacttt tagcaaagtt
    10681 gtctatttta gtatcaatta atttactcat tggcttttct ctcctcactc gtattataca
    10741 attttaatta agttttatgc gtcttattgc ttaactgtat atttttaatt cctaactgtt
    10801 taaaatattt atctgactaa ttttatcata tttatgctta catttaggaa taaaatttaa
    10861 cgagttaggg atttttttac attaatttaa ataatcatgg ttaaatgtac ttgtatcaca
    10921 aagaagtgat tacattttac aaatcattta atcaaaattt tgtttgaatt tttgtttgaa
    10981 tgataacgtt gattagactt ttgagcaggg gtctgattaa cacactgata ttgtaactgt
    11041 acttacttcg tatagttgtt atagttacaa gttaagttct cgtttttcaa ttaattgatt
    11101 acaaacaaga ggaggctgat gtagtgacaa accatttctc agcaatgatt agtgatttcg
    11161 taaaataata ctttcaggta cacaacgcgc ttaattttat taagcaatcc caaaatttgg
    11221 attcgtagaa cattcccagt ctcaattcaa atatcatttt aacattgcct ataacagagg
    11281 cgatttaaag taaaacatgt aagctatcgt aaacatcatt caatttatca ttttaatcgg
    11341 taaattcact aaattttttc ataattaata acatccccaa aaatagatag agaaataact
    11401 gtaaaaacat tcccttaata ataagttaca aaaaccgtga gtccctccca agctcacggt
    11461 ttttttgtat ttatttgtat agatgagggc gaagattttt gaaaactggg atattttctc
    11521 tttgattact aacctcatcc aagttgatac cgcatgaaat atgatctggc ttatcttcta
    11581 attgggcgac tatttctcca tttggattga ttacgataga atgtccagca tattctgttt
    11641 gtccgtcatc tccacacgca ttacatccta caacaaacat atcattttca atagcgcgtg
    11701 cttttaaaag tgctatccaa tgacttactc ttgcttgagg ccattgtgct acatagaagg
    11761 ctatctctgc atctttccga gcaggatagc gtaataattc agggaaacgt aaatcataac
    11821 aaataatttg tgtagcttta acgccattag ttaagttaaa cgcctcaggt acagcattgc
    11881 cagcagttaa gaatgaaggc tcgtctaaca taggaactaa atgaactttg tcataactat
    11941 tgattaaata gccatttttt gaaactgcaa atgctgtatt atacacatcc tctttcatag
    12001 aatttgaaac agaaccagcg ataatatcaa cgtcgtattg aattgccaac tttgatataa
    12061 attcatagct acgcgaaagt tgagtatcag caagttcttt taattggggt aaagcgtacc
    12121 cattattcca catttctggt aatacaacga catcagtttc tgaggttaca aatttagaaa
    12181 accaattaac tatgttttct tcatttaatg aaacatttgc cggttcgatt ttaaattgaa
    12241 aaacttctat attcattttt atcgcccctt aaattattgt tagcatcaat atactaaaaa
    12301 aattctgata attcaaaatt agtaaatgct tgatatcaat aattatataa aggtaaacag
    12361 ttttagaaac taagggaaat gcttattcgt attttattta acataagttg gaggaggggt
    12421 aaatattata agtgtaaatc tatgtgtagg ataatgtact tattaatttg atagatataa
    12481 gatataaatt tacttaattt aaagtaaatg tgataaatca tttaaaatca taagaggtcg
    12541 agacagttat atacgctcga cctcttattt tataaaagac tacaacaaat taagtgaatg
    12601 tgattatttt ctaactaaaa aacgtttact tgtatcatgg aactctttgt ctccagcttc
    12661 atcgcgaata ttaccgaatg gcatttgtgc aacaagtttc catgttttag gtatttcaaa
    12721 agcttcagaa acggcaacat ccacaagtgg attgtagtgt tgtaaagaag caccaatgcc
    12781 aacagtactt aaagctgtcc aaattgaaaa ttgatgcatt gcgtttgttt ggctagacca
    12841 cacggcaaag ttttctgcat agttaggcat ttgattttgt aatccttcga taacatcttg
    12901 gtcttcaaag aaaagaattg taccatgaga atgtttgaaa ttgtctactt tgtcagaagt
    12961 tgcttggaaa tcacggtctg gacccatagc atttttaagt tcttgtttag tgatttccca
    13021 gaatttatta tgattatcat ttaaaagtaa tacaatacgt gtagattgag aattgaatga
    13081 tgatggaaca tgtttgatag catgctcgat aatatcttct acttcattat cagagattga
    13141 aatatcctga tctaaactat atatagtacg tcttttttct attgcgtttt gaaaagtttc
    13201 taaagttgag tcttttttac tgaataatcc cattgtgaaa gctcctttat atcaatttat
    13261 tttatatatt aagtataata attatatcag agtttgtaaa tagggggtta cataaaattt
    13321 caaaaggatt aatatttgtt ttcaataaat tagttttgat gaaaaatagg tctttttctt
    13381 atatactata tatgaatata aaaaatatga attttggagg tgaatctatg aagtggtatt
    13441 tttcgcataa atttgtgatt tccagctttg ctctcgcttt aagtacgaca ttagtttcta
    13501 gtcaaactca cgctgctgaa caacaaattg atgaaaaatt aacaaataat aacacaaatc
    13561 aatcagataa aaggccaatt cattctaatc ctgcaaatca tataaaaagt ccaaccacag
    13621 tagaggatac ggtacaaagt gataatacaa ctaatcaaga gtcagataac gatttaggtg
    13681 aaactgttca agataatgaa aaaatacaaa atgattggga taagcaaaat actaataatg
    13741 atgaattaag cgatgttcaa ggacaacaag acaacagtaa cttaattgaa caaaatcaat
    13801 ctaataacga taatagcaat gaaatgaatg aacaaccaaa tccagatgaa tcaaataatg
    13861 gagatggaac agacgaccaa ccgaatccag atgaaccaaa taatggagat ggaacagacg
    13921 agcaaccaaa tccagatgaa tcaaataatg gagatggaac agacgagcaa tcaaatccag
    13981 atgaaccgaa taatggagat agaacagacg agcaaccaaa tccagatgaa ccaaataatg
    14041 gagatggaac agacgaacaa ccaaatccag atgaaccaaa taatggagat ggaacagacg
    14101 aacaaccgaa tccagatgaa ccgaataatg gagatggaac agacgaacaa ccaaatccag
    14161 atgaaccaaa taatggagat ggaacagacg agcagccaaa tccagatgaa ccgaataatg
    14221 gagatggaac agacgagcag ccaaatccag atgaaccaaa taatggagat ggaacagacg
    14281 agcagccaaa tccagatgaa ccgaataatg gagatggaac agacgagcag ccaaatccag
    14341 atgaaccgaa taatggagat ggaacagaca aaccaagtgg gggaggttca gaaactccag
    14401 ataaaccagg gaatggagat aatggaaata cgcaaccaaa cccagatgag ccgaacaatg
    14461 gaagtggttc agacaaacca agtgggggag gatcagaaac tccaaaaccg cctaatgaag
    14521 atagtgatac aaataaaccg aataatggta accatgctgg tccaaataat tcgaataaac
    14581 caggcaataa tagtaattta agtccatcta aacctaataa ccaaggtgat tcaaatgtaa
    14641 catctaatca gggcggcaat accaataaca attcaaatac aaataaccat tcgataaatc
    14701 acgccaatga caataataat gagctgcaat atggaagttc tagtcatcat gaaattgcaa
    14761 gtggtggcgt ttcagcaagt tatggtgatt tagctaaaaa tgaaaaatct caatcgaatg
    14821 aaaaacaatt aataaataga tttgatcaaa tgtcttcagg ttcgtttaag tataatcctt
    14881 ttgtagtgaa tcaagttaaa cagttgggtt ctagtgctaa aacagttact gataaagata
    14941 tttcatcggt tttaagacgt caaacttttg ctgataatgc atttttaaat gaattacaaa
    15001 aaggcacaaa ttattttaaa ttccaatatt ttaatgtatt aaaatcaagc gattattata
    15061 aaaatctaga caaccaagta ctagcgttaa ttacaggtga aattggttca atgccagatt
    15121 taaaaaatcc taaaagacaa caatcctctg gaaaatatga atatcattca agtagtgagg
    15181 atgaattaac gcatacaaca aatgaacaat ctaaaaatga aattgatgtt aaattcgaac
    15241 gtacactatt tgctttaatc actgcaatga taattatctt tattggtatg gttttaggat
    15301 ttatcgtaaa tagaaaaaat aaaaaagata gtgaataata atcaaaatct aaaaagggaa
    15361 gaagctttga cataaaatga tgtcgtagcc tcttcccttt aatgctttta taatgattaa
    15421 aataaaaagt taaaaataaa tgacgcggaa tcttgcattt cttttatttt ttctggtcct
    15481 actaatactt gaattataac tacaaaacca ttttgcataa tatgtactaa aataggcacc
    15541 caaattcgtt tagtataaac atatagtgct gagaaaatta tccccatacc aaagtaaata
    15601 ataaaaaagg aaggatctga atgggcagca ctaaaaataa ttgaacttac aattcctgca
    15661 atcaaaaact taatagtttt atttgcttgg attacattat aaatttcacc gaaaattact
    15721 tttctaaaaa caaattcttc taaaataggg ccaaccactg aaattaatac aataaatata
    15781 ggaatttctt gagctacttt cataagtctt tctgtatttg gacttgattg tggtgcacct
    15841 aataagtaga tattaatcat gttagcaatt atttgataaa tcattactac gaagtagcca
    15901 acaagcgccc atccaatagc atatcttttc ttttctttgg gcttttgttc caaggaagta
    15961 ggattagcaa tgaaatgatt aattataata attatgaaag acgcaataat aaataatata
    16021 acttgcgtat aaatttgtgc aaagacaagt tctttgccac tatagtgatc aaataggcca
    16081 gacaattgca gaatgatgat accaaattgt gctaaaccat atataaccaa tgtcaatatg
    16141 gacacccata aacgagacat aatgaacctc caaaaattaa atgatatctt attttatcgt
    16201 aaaatagtgt tttatacaaa atttagctga atagttttaa cttgaaatat tgaccaactt
    16261 tgattattat agaagtacat tagcactcat caactttaag tgctaaacaa ttttattctt
    16321 tttaaggagg aacaatcaat gttaaagcca ttaggtaacc gagtaattat tcaaaaatca
    16381 gaacaagagc aaacaacaaa aagcggtatt gtattaactg atagcgcaaa agagaaatcc
    16441 aacgaaggta cgataattgc agtaggtgca gggcgtattt tagaagatgg ttctcgtgtt
    16501 gctcctgaag taaacgaagg cgataatgta gtatttcaac aattcgctgg aacagaagta
    16561 aaacgtggag acgaaactta tttaattgtg aatgaagaag atattttagc tattattgaa
    16621 tcataaaaaa tcataaaaat tctgataatt tcaaataaat caatataaca tcatggaggt
    16681 ataattaata tggcgaaaga tttaaaattc tctgaagacg cacgtcaatc tatgttaaga
    16741 ggtgtagata aattagctaa tgccgttaaa gttacaattg gaccaaaagg gcgtaacgta
    16801 gtattagata aagaatatac atcaccgctt atcacaaatg atggtgtaac aattgctaaa
    16861 gaaattgaat tagaagatcc ttatgaaaat atgggggcaa aattagtcca agaagttgct
    16921 aacaaaacta atgaaattgc cggtgatggt acaacaactg caactgtttt agcacaagct
    16981 atgatacaag aaggattgaa gaacgttact agtggtgcaa atccagtagg cttacgtcaa
    17041 ggtattgata aagctgtaga agttgctatt aatgcattac atgatatttc tcaaaatgta
    17101 gataataaaa atgaaattgc ccaagttggt tcaatttctg ctgctgatga agaaattggt
    17161 aaatatattt ctgaagctat ggaaaaagtg ggtaatgacg gcgttattac aattgaagaa
    17221 tctagtggtt ttaacacaga attagaagtt gtagaaggta tgcaatttga tcgaggctat
    17281 caatcaccat atatggtaac agattcagat aaaatggttg cagaacttga aaaaccttat
    17341 atcttaatta ctgataaaaa gatttcatcg ttccaagata ttttaccatt attagaacag
    17401 gttgttcagt ctaaccgtcc aatcttaatt gtagctgacg atgtagaagg tgacgcatta
    17461 acaaatattg tattaaaccg tatgcgtggc acatttactg ctgttgctgt taaggctcct
    17521 ggttttggtg atcgtcgtaa agcgatgtta gaagacttgg caattttaac aggagcgcaa
    17581 gtaatcacag atgacttagg tttagatatt aaagatgcta caatcgatat gttaggtaca
    17641 tcaaataaag ctgaaatcac aaaagacaat acaactgttg ttgatggtga tggagaccaa
    17701 aataatattg atgcacgtgt aagccaaatt aaagctcaga ttgaagaaac agactctgag
    17761 ttcgataaag aaaaattaca agaacgttta gctaaattag caggtggcgt agcggtaatt
    17821 aaagttggtg cagcaagtga aacagaattg aaagaacgta aattacgcat tgaagatgcc
    17881 ttaaactcta caagagctgc tgttgaagaa ggtatcgtag caggtggagg tactgccttc
    17941 atgaacatct atgaaaaagt ttctaaaatt gaagcagaag gcgatattgc aactggtatt
    18001 aatattgtat tgaaagcttt agaagcacca gtacgccaaa ttgctgaaaa tgctggatta
    18061 gaaggttcaa ttatagttga aagacttaaa aatgcagatg taggcgttgg tttcaatgcg
    18121 gctacaaacg aatgggtaaa catgttagaa gctggtattg tagatcctac aaaagtaaca
    18181 cgttcatcac tacaacatgc tgcaagtgtt gctgcaatgt tccttacaac agaagcagtt
    18241 gttgctaata ttccagaaga aagtagtaat gacactcaag caggtatggg cggcatgcca
    18301 ggtatgatgt aaagtttcat ataaatattt aactaaatag catgagactt ctcttgctaa
    18361 ctttaataaa ttatatgtag taaaagttat agaggctggg gcaattttta attgtcccag
    18421 ccttgatctt tgtattggca gtaactcact ctattgaaaa atagacttac tgtatatcta
    18481 acatacatgc tgattaagac agtgtaatcc attttagtga aaagtagttt atgttatgga
    18541 tccttaatcg ttaaacataa ctaataaata atattgttaa ccaaaataaa agagcgagcc
    18601 aaattaataa aacgagaatt gccataaaac gatccttcga tttgttctat ccatagtcat
    18661 ttgattttga aatgtggata taacttttag aatgattgat aaagattgaa agttaatgag
    18721 tcctaataaa acagctcatc attttgatac tttgatgaaa aaatataaac aaaaagtacg
    18781 cgtaatacaa tttctatgtt tttcatttta agtaaatata tttatagaaa tattgaacga
    18841 ttatttagag agtatttaat aaagtataat atagcattaa attttaaagt attgcgcttt
    18901 tgaacaaatt atataatgtt aaaagtgtgg tatatagagc ttctatatct attaaaatga
    18961 aggattagtg catttaaatt aagtttataa atttttcatt tctaaagcat tttattatgt
    19021 gaatatttaa ttatagttta gggtaaagta tgtaagtata attagaagcg gttcttatac
    19081 atgattttaa gtgtacttaa atttttgaaa gacgaaagga agtttaatta tgacaaaacc
    19141 aacagtttat gaagttatcg atttaggtat taattattta atatcaggat atgataactg
    19201 gagtaacgca caggtgctag atgataagat tgctgccttt ccaaatacaa ttcattggca
    19261 atatggacat gtacttacga tatttgaaag tgcattatca ttatgtgaac aaaatgaagt
    19321 agatattgct aaatatacaa gtttatttgg atacggttct tcaccagaaa agtggggaga
    19381 tgaagatatt cctaccgttg atgaaatatt tgaacattta aaaacattac ccaaccgtgc
    19441 cagaaattta actgatgaac agttagaaca agaattaaca gaaactatcg ctggttgcag
    19501 tacgttaaat gaattattag tactcaacgc gattcatgtt ccattacacg ctggtaaaat
    19561 tgaggaaatg tcacgtatac ttaaacaaca tcaataaata tagcaaattt aatcagtcca
    19621 gaacgtaaat aagtatttgg gctgttttaa tgtatagtta ttttttgtgt gttgggctag
    19681 cttaaagaga aatcttgtta ataaaagtta ctatcgtgac acacccaaga cgttggatac
    19741 ttgcaagtaa tattaactta tatttgcaac taacctaaga tttttcagtt ataacaaaag
    19801 agggcaacga aagtttatta ataagctttc gttgctctct tttattttat attaaatcaa
    19861 taaattattt ttgtaattct gagattgctt ttgctattgt atcaaataca tgagggatat
    19921 cgtctttttc cacacaactg aacgcgatac gtatatcagt atcgttaagc gcaatgatac
    19981 caattgaata tgtttcgatt aaacgtaaac gcaattgctc aggatctaca ccatgaactt
    20041 ttaatgccat gaaatatcca gaattaaagt catatgcttg ccaataaggc gcatattgct
    20101 catcataaac tactgattta gtgatttcat atctcgcttg tagggtgtca atattatgtt
    20161 gtatttcact ttcgaaagtc tcagggtgtt ccaaaacata ttttacagca ctttgagaag
    20221 gcattggacc gcttgagatg ttgcttctaa ttaatccttt tactttttct tcaagtacgt
    20281 gtttcgtcat ttcatttgtc acaccaaagc taatgaaacc aacacgaagt ccccatgcga
    20341 aaaattcttt tgtagcacca tctaaacgga ttggcaatat attatctaaa tgtaaatttg
    20401 ttaacgcagt aaatagtgat tgtgtataaa cgtcttcata aaataaaccg taataagcat
    20461 catctactaa agcaataaca tttgtccctc gttctgctaa agatttgata gcagtcacta
    20521 ttgtactaac ttcttcttta gtaggtgtgt agcctgttgg attatttgga tagtttaaaa
    20581 ttaaaactac tttatctttt tggtaatttt ccaaagtatc aacaaaatta tcagttgtaa
    20641 aatggccatc ttcatcaaag atatcgtacg tttcaatatc agcgctgtgt ctagcactat
    20701 atacaagttt
//
