LOCUS       NZ_PIZP01000004        22559 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Staphylococcus shinii strain INIFAP 005-08 NODE_4, whole genome
            shotgun sequence.
ACCESSION   NZ_PIZP01000004
VERSION     NZ_PIZP01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Staphylococcus shinii
  ORGANISM  Staphylococcus shinii
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 396061)
  AUTHORS   Lopez,G. and Munoz,A.
  TITLE     Phylogenomics unveils the most efficient molecular markers for the
            species phylogeny - the case of the genus Staphylococcus
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 396061)
  AUTHORS   Grana-Miraglia,L., Miranda-Mirand,E., Arreguin,C., Cossio-Bayugar,R.
            and Castillo-Ramirez,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-DEC-2017) CCG, UNAM, Av. Universidad, Cuernavaca,
            Morelos 62210, Mexico
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-FEB-2017
            Assembly Method                   :: Spades v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 337.1969x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002836835.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 11:05:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,976
            CDSs (total)                      :: 2,900
            Genes (coding)                    :: 2,859
            CDSs (with protein)               :: 2,859
            Genes (RNA)                       :: 76
            rRNAs                             :: 7, 4, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 3 (5S, 16S)
            tRNAs                             :: 60
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 41
            CDSs (without protein)            :: 41
            Pseudo Genes (ambiguous residues) :: 0 of 41
            Pseudo Genes (frameshifted)       :: 22 of 41
            Pseudo Genes (incomplete)         :: 25 of 41
            Pseudo Genes (internal stop)      :: 13 of 41
            Pseudo Genes (multiple problems)  :: 13 of 41
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:11:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 255598
            Orig. end                         :: 278157
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            PIZP01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22559
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="3"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22559
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22559
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12559](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12559)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(2787..3536)
                     /locus_tag="CW747_RS08170"
                     /old_locus_tag="CW747_08165"
     CDS             complement(2787..3536)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0008170 - N-methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006306 - DNA methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003469307.1"
                     /locus_tag="CW747_RS08170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_08165"
                     /product="N-6 DNA methylase"
                     /protein_id="WP_101050657.1"
                     /transl_table=11
                     /translation="MSEIIIKSKSRVQKHGEVFTPRKIVNKMLDSPGIKECCENLTSTF
                     LEPAVGEGAFLIVILERKLDMVAKKHNESLNQYENYSLLALSTIYGIELLEDNAQNCTM
                     NLFQVFYEKYNAQLNKYGKSYMNPKVLDSAKLIIATNISQGNFLTRYTNADKPIIINEW
                     TAINLDRKPKIIKIIRTEYTLDEIYQGISKELGEPIIDSPSKKESEQLSFFDDLLKSEK
                     NTVSKAHYVPSKIIDVYKEEMEEVNED"
     gene            complement(3745..5064)
                     /locus_tag="CW747_RS08175"
                     /old_locus_tag="CW747_08170"
     CDS             complement(3745..5064)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002458510.1"
                     /locus_tag="CW747_RS08175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_08170"
                     /product="SEFIR domain-containing protein"
                     /protein_id="WP_101050658.1"
                     /transl_table=11
                     /translation="MNKKAFISYSRTSKDHLKRVVRIAENLRVDHGIDVILDVWDCTEG
                     DDLNYFMESMVNDKTIDFIIILSDFQYFNRANDREGGVGKESTIITSQIYDKQRDSKFI
                     PVFLDILSNGKPALPTFCNTRFAIDMTDIELDIEKAEEIARKVHNKPLFEKPKIGNVPD
                     YNQDHNDLKKAIKKLTLSKSYNETRNFEEALDIIYKTLENIENSVEEYNKDDLMTLKEV
                     FDTWKELITYALNNDNFYFRELIIEHYNRCLMLTEEEFKNPMTRIFNYFSFLILVSEAL
                     SSGANEFLKDLLNAKFHFSRREANYYILSLYPQALSRKYSYNTNVKKMLAEIYFEGKDL
                     KKVQDADVILYTESLIKKDIHSVYETWHGVLSYSKWPTLEQQTINILINKFRSKKYLDQ
                     FDFLFGSSQREVFENYDKIKSTQEIPTIFNFIDKEEIGSY"
     misc_feature    5641..5652
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.35"
                     /tool="antismash"
     misc_feature    5849..5863
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.77"
                     /tool="antismash"
     gene            complement(6054..6674)
                     /locus_tag="CW747_RS08180"
                     /old_locus_tag="CW747_08175"
     CDS             complement(6054..6674)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002449486.1"
                     /locus_tag="CW747_RS08180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_08175"
                     /product="NDxxF motif lipoprotein"
                     /protein_id="WP_101050735.1"
                     /transl_table=11
                     /translation="MKKLLILGILFLLIFITGCSNGHNTDINKADNSYKKVEKKSLPTK
                     IFDNKTTNSQLSEQEIKDSIKLYLNSDDDLSKAKEYYQDKLDSEEKLSEVDSKEIKQLN
                     KLTRENDNNFYNYIKNNRLPEGYNKYAFKISKYISTSNKVFENLDKQIDLTMNKLTEDG
                     EIPTEDFDEIKYDSKIVNGKEQDKIEKFLKEKNIKTRAFKNTE"
     gene            complement(6674..7240)
                     /locus_tag="CW747_RS08185"
                     /old_locus_tag="CW747_08180"
     CDS             complement(6674..7240)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002454678.1"
                     /locus_tag="CW747_RS08185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_08180"
                     /product="DUF1700 domain-containing protein"
                     /protein_id="WP_101050659.1"
                     /transl_table=11
                     /translation="MTKDEYIATLNRCIKRMNKEDKKDILNEYESHFISGYKDKKNDEE
                     IIRGLGDPIDISKEINAMNALNIVEKEKSIKNIFIATFSIMGLSVFNFIVIGLSLFIFL
                     LLLPFIIAYIIAVPVMLSSPIILFIIGIINGFDTITVSDVFEVIKGVILGVILGLIGYY
                     FVKNFFKFIIFYLKWNLNTFKRESL"
     gene            complement(7227..7556)
                     /locus_tag="CW747_RS08190"
                     /old_locus_tag="CW747_08185"
     CDS             complement(7227..7556)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002451950.1"
                     /locus_tag="CW747_RS08190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_08185"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_101050660.1"
                     /transl_table=11
                     /translation="MNVQFKKGALELLVLLIINNNDQYGYSLIQIIAKKIAISEGTIYP
                     LLRRLVKEGYLNSYYEPSREGPSRKYYAITVKGNERLKKLTEEWNMFTESINSFMKESD
                     IHDKG"
     gene            complement(7646..9358)
                     /locus_tag="CW747_RS08195"
                     /old_locus_tag="CW747_08190"
     CDS             complement(7646..9358)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011117499.1"
                     /locus_tag="CW747_RS08195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_08190"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_101050661.1"
                     /transl_table=11
                     /translation="MNVYKVFKLTINNKKKKIYLALIIFLSLIFTIASLYFPILIKNII
                     NELENNRINTLVIISLVSFLILRSLIEGINEYIISKFGNIIIKDLQQNIYNKIIHYPIS
                     FFDKYKSGELSSRLVNDTEVIKDLITFHIPKVINGVIMVIGAIVLIAFLDWELTIVILL
                     IAPLIFGIIFPLMKKLEDTGEKQQYEISNFISQTQETFKNIKMVKASTAECSEKNIISR
                     HINNLFKVNLYESKVMAFISPLVNFLLIFGLLVIAGYGAYRIQNGTLELGTLIAFIIYS
                     FQLMSPMSSISSFIGEYHKANGAFRSLTKIINEDVERKNDQYTYDFRLNNNLSFNNVTI
                     EFNGKKILDDISFTLNKGNSLTIIGPSGSGKTTLLNLLEKFYTVEKGTITVDGVDINQI
                     STHSLRKNIGLVSQDIPIISGTIKDNLLYGLREETITNDKIQKSLDFSILNKLVTNQID
                     NLNSYVGESGNKLSGGEKQRINLARLFLKNPSIILLDEATSNLDNESKSEILKSISDLT
                     RNRTTLKITHNIQELHENEEVLFIENGKILFKGIHGELLKNSERYKKFIKIIS"
     gene            complement(9437..9556)
                     /locus_tag="CW747_RS14915"
     CDS             complement(9437..9556)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038159.1"
                     /locus_tag="CW747_RS14915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_198553049.1"
                     /transl_table=11
                     /translation="MNKVLSLQQETISKEVQLKAKSSRSQNCKKSSHASWFFC"
     gene            complement(9581..9706)
                     /locus_tag="CW747_RS14920"
     CDS             complement(9581..9706)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038159.1"
                     /locus_tag="CW747_RS14920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_198553050.1"
                     /transl_table=11
                     /translation="MSMNKVLSLQQETISKEVQLKAKSSRSQNCKNSSHASWFIC"
     gene            complement(9725..9850)
                     /locus_tag="CW747_RS14925"
     CDS             complement(9725..9850)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038159.1"
                     /locus_tag="CW747_RS14925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_198553050.1"
                     /transl_table=11
                     /translation="MSMNKVLSLQQETISKEVQLKAKSSRSQNCKNSSHASWFIC"
     gene            complement(9869..9994)
                     /locus_tag="CW747_RS14930"
     CDS             complement(9869..9994)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="CW747_RS14930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_198553052.1"
                     /transl_table=11
                     /translation="MKQVLDLQQMRSKSGKKKPSPKQSSASWGCAPSSNTSWFFC"
     CDS_motif       complement(9944..9994)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKQVLDLQQMRSKSGKK"
                     /locus_tag="CW747_RS14930_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9869..9943)
                     /prepeptide="core"
                     /locus_tag="CW747_RS14930_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-2.60"
                     /molecular_weight="2446.7"
                     /monoisotopic_mass="2445.1"
                     /core_sequence="KPSPKQSSASWGCAPSSNTSWFFC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKQVLDLQQMRSKSGKK"
                     /leader_location="[9943:9994](-)"
                     /alternative_weights="2464.7"
                     /alternative_weights="2482.7"
                     /alternative_weights="2500.7"
                     /alternative_weights="2518.8"
                     /alternative_weights="2536.8"
                     /alternative_weights="2554.8"
     gene            complement(10001..12559)
                     /gene="lanKC"
                     /locus_tag="CW747_RS08200"
                     /old_locus_tag="CW747_08195"
     CDS             complement(10001..12559)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000347596.1"
                     /locus_tag="CW747_RS08200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_08195"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_101050662.1"
                     /sec_met_domain="micKC (E-value: 5.8e-138, bitscore: 455.5,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.4e-13, bitscore: 45.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.4e-37, bitscore:
                     123.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYRYVKYINDSCYYTKPTNQNVGYINLDYIPSNFTKVSGDHWIN
                     ISNYNQTLPEQGWKIHISTQLKTAKQTLDSVAELMFNENVSFKYVKSMHELMLKDSKYG
                     DRSSSGKFITIYPSSTDQFLDLLLKLEEKLSHLPKGPYILNDKRWYKSNIYFRYGGFMP
                     KTLYKNGEILDAIEDLNGNLIEDQRKPFYSVPDFIEEPSQIKKMDLESEKEYERTCIDD
                     YSIKEALHFSNGGGVYLADHEKWGEVILKEGRPYTASGLDDVDAFKRIHNEGEILKKLK
                     DAHYPVEVYDDFVAWEHKFIVEEYIKGNSLTIWIVNNYPFSSKEKNKEYVKSSVNILNE
                     LVKSIEEIHSLGIGFGDLQPANIMVTSDERIRLIDFETAGSVEDSIATVMTPGFIGDPK
                     MCKEQSDWFAVLRIAKQMFIPIGNVQDISHNLDKIHTKWIEKVFGLEALNIIKKIEKIC
                     KRHNARPMKQLIDSTETLVRDFNLISIKEKLINAIKKDLNNEELLIHGDIRQYEMDSGK
                     WNVLTGGFGVIMALKRANEWDERLNKWIENIEEEILINLEDGLYTGKMGICNVLIEAKY
                     TDKAKKLLETIDIDSNKHDISIASGLSGLGLGFLSIYYEFENDYYLSKCKQIAELLENN
                     FEKDTPVYTFDYDIVDKGFLTSWSGASLFMSSLYKATGEKKWLDISKKMLDRELEKTLF
                     DEDGLFQTDDDFRILPYLSSGGSGLAIPMLEIQSIENSNKWIKELEGIAKIAHSKTFYN
                     AGLFQGATGILAISHLLDKYLNRKDLVNSSLFTLNLYLIETDDCLYVPGDSCFRVSSDL
                     MSGAAGLLTVIQDIISGSHFSWIPLFNINKILNLDSIKRG"
     gene            complement(12622..12762)
                     /locus_tag="CW747_RS14810"
     CDS             complement(12622..12762)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038159.1"
                     /locus_tag="CW747_RS14810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_157822560.1"
                     /transl_table=11
                     /translation="MEKNNVLKLQSMRSKKSSNHQASNASVMCKKQSSASIIFCVFPGG
                     K"
     CDS_motif       complement(12694..12762)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKNNVLKLQSMRSKKSSNHQAS"
                     /locus_tag="CW747_RS14810_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12622..12693)
                     /prepeptide="core"
                     /locus_tag="CW747_RS14810_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-3.10"
                     /molecular_weight="2330.8"
                     /monoisotopic_mass="2329.2"
                     /core_sequence="NASVMCKKQSSASIIFCVFPGGK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKNNVLKLQSMRSKKSSNHQAS"
                     /leader_location="[12693:12762](-)"
                     /alternative_weights="2348.8"
                     /alternative_weights="2366.8"
     gene            complement(12774..13448)
                     /locus_tag="CW747_RS08205"
                     /old_locus_tag="CW747_08200"
     CDS             complement(12774..13448)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CW747_RS08205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CW747_08200"
                     /product="hypothetical protein"
                     /protein_id="WP_101050663.1"
                     /transl_table=11
                     /translation="MLHKSKECRKITTKNVGIIKTLINGEEMTSNASVIFWEDKPLIIT
                     SAHSVYDWYSEKFSEKVNFFDYLGGKINIDYIILSKRWINEGILDFDTAILFPEKINMH
                     RYDKIRPKFCVTKPAKVLIISQKRGLFKNKVVSYERNIFNDDIYKSSMIGIKLKSNSGL
                     SGSPWYYECNNKQYQISNTSLSFKKKKRLTFAPYWGRYIEEMFEFTENSIYNNEFIYHQ
                     LN"
     gene            complement(13984..14529)
                     /locus_tag="CW747_RS08210"
                     /old_locus_tag="CW747_08205"
     CDS             complement(13984..14529)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000592150.1"
                     /locus_tag="CW747_RS08210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_08205"
                     /product="YdhK family protein"
                     /protein_id="WP_101050664.1"
                     /transl_table=11
                     /translation="MIKKLIFILLGSMLALSACSNSDEKNEDTKDQKSESHMKHNDESK
                     APEDMTSTDQGKFKPGDKVTITAGHMPGMKDAEATVKDAYKTYAYVVTYKPTNGDKKVN
                     NHKWVVNEEIKDAPKNGFNKGDTVKLEADHMPGMKGATANIDDVKETPVYMVDYKPKDN
                     GKTVKNHKWLTENELKAR"
     gene            complement(14547..16637)
                     /locus_tag="CW747_RS08215"
                     /old_locus_tag="CW747_08210"
     CDS             complement(14547..16637)
                     /EC_number="7.2.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0015662 - P-type ion transporter activity
                     [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0019829 - ATPase-coupled monoatomic cation
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002449344.1"
                     /locus_tag="CW747_RS08215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_08210"
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="WP_198553053.1"
                     /transl_table=11
                     /translation="MRNNGEEHNLNHENHMNHSNQIHHEAHEHHDHHEAYSHHNGHEHH
                     HHGNFKVKFFVSLIFAIPIIILSPMMGVKLPFQFTFPGSEWVVLILGTILFFYGGKPFL
                     SGGKDEIVAKKPGMMTLVALGISVAYIYSLYAFYMNNISSTPGHTMDFFWELATLILIM
                     LLGHWIEMNAVGNAGDALKKMAELLPNSAIKIMDNNKREEVKISDIMIDDIVEVKAGES
                     IPTDGMIVHGQTSIDESLVTGESKKIQKNQNDSVIGGSINGSGTIQMKVTAVGEDGYLS
                     QVMGLVHQAQNDKSRAELLSDKVAGYLFYFAISVGVISFIVWMLIQNDVDFALERLVTV
                     LVIACPHALGLAIPLVTARSTSIGAHNGLIIKNRESVETAQYIDYVMMDKTGTLTEGNF
                     SVNYYESFKDDLSNDTILSLFASLESQSNHPLATGIVDFAKSKNISYASPQEVNNISGI
                     GLEGSIDSKKYKITNISYLDKYKFEYDNDLFVELAQQGNSISYLIDEQQVIGIIAQGDQ
                     IKESSKQMVADLLSRNITPVMLTGDNNEVANAVAKELGISDVHAQLMPEDKESIIQDYQ
                     SNGKKVMMVGDGINDAPSLIRADIGIAIGAGTDVAVDSGDIILVKSNPSDIIHFLTLSN
                     NTMRKMVQNLWWGAGYNIVAVPLAAGVLAFIGLILSPAVGAILMSLSTIIVAINAFTLK
                     LK"
     misc_feature    16676..16692
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: medium, score: 26.71"
                     /tool="antismash"
     misc_feature    16693..16708
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 19.26"
                     /tool="antismash"
     misc_feature    complement(16693..16709)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 23.42"
                     /tool="antismash"
     misc_feature    complement(16694..16709)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.77"
                     /tool="antismash"
     gene            complement(17569..18003)
                     /locus_tag="CW747_RS08220"
                     /old_locus_tag="CW747_08215"
     CDS             complement(17569..18003)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000592130.1"
                     /locus_tag="CW747_RS08220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_08215"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_101050665.1"
                     /transl_table=11
                     /translation="MIKKLDNLDSESIEKISNIWLNSNLDAHDFIKREYWIDNLSKVKK
                     MFPDSTIYVYYDDNQIVGFAGLYEQYIAGVFITEKHRNKGIGKLLLERLKSDYNGLNLH
                     VYEKNEGAIRFYTKHQFEIRSKEFEAETQEYEYLMKWDSN"
     gene            complement(18408..19631)
                     /locus_tag="CW747_RS08230"
                     /old_locus_tag="CW747_08225"
     CDS             complement(18408..19631)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CW747_RS08230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CW747_08225"
                     /product="hypothetical protein"
                     /protein_id="WP_101050666.1"
                     /transl_table=11
                     /translation="MEMNRFDIYRELWTKSRTAFAEEHNIEFNDLKKIIEIHKIPLPNS
                     KYLYDYRRGIIGQLEPIEGEDYSIKLDEKLSEKTKITNKWSYFDDDKKEEIYNVYTELK
                     IPDKVKRHHKIVTKHKNYLTSERRREREAEMKLWGYYRSEPQKVLNTSHISKEALPDFY
                     RLCDTLFKAIECLNFKVSVDEEYICIHIARRDKQVKKSDLMYLKLNVFHIKLRFKEKKK
                     RVKRDDNRYSSYDYLNTGYFKAELVGVYPWGNNVYGINRDYPGTDDNNTLMKKIFERIF
                     ELPQLLNDAELEYIEKQNEEERKRKEAEQLRKSKESEFNNIKTLISEYKLHKEIKALTE
                     YINEYKLKNATIEEMMWYKETLTWLKDSSKVEKALGDRNHDQIVKYLLNEMKESDVDFH
                     DPSSYRWW"
     gene            complement(20033..22195)
                     /locus_tag="CW747_RS08235"
                     /old_locus_tag="CW747_08230"
     CDS             complement(20033..22195)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024565.4"
                     /locus_tag="CW747_RS08235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CW747_08230"
                     /product="AAA family ATPase"
                     /protein_id="WP_101050667.1"
                     /transl_table=11
                     /translation="MLNKLENVSYKSFDNYTSKDDLNKVNIFFGRNGSGKSSLSEWLRR
                     LDNEKSVIFNTGYLKNNIEEVEEIDGVSLVIGEESINHSDQIKHLNSAINNLENFITRK
                     DNEIMHSKKRIYDKMNIRLNEARKKFEIGSNVVKQKRNADKDPVNAFYSWKKNTNDIIE
                     ETTIESLDELEERITSKEVLLNNIKTPILAFDYDEFSNMVKLLMKEVIKPTSSVSYKVS
                     EWLKDGLEIHNMQSKEETCEFCGNIFDVELLKESIDVRIKNEFSYLIGNLNNYKTKINK
                     SLSNLEDLNIDIDLVDYSNQKEELIRLLHILEDKEVKTYEHLEYPMDNWESINIIDNIV
                     NSYIENLKKEIQNDKNIRDSIADFVKSWIGKKLKNDEEIQMEISNINSNSKQIKESEEC
                     ITENNDWITKLKTNSSNLKQFSEIVNKRFETLDINIELEPNIEIKSYRVLHRVTKEKLK
                     LVDLSEGEKRLIGFLHFYYNLFMIADSEMKENIEYIIIDDPITSLDTENRYHLTKIINQ
                     FIELSKSVNKQVFVFTHSSFDFHNFAFKGKNNTKETSYWYIEKIDGISKVNKLSKEELS
                     NYSDYYRTVFNEVMSFAIKGKSKVNKIDNYIKYANKVRFILESHARSHYKIEYATAASV
                     TELSKYYNIADEKIGDLKESLDIINSLSHGISFIDNHYYELSVTEVHKAIRKVIGIIYN
                     KDKQHVSAICSGVLNKENKEELQKWI"
ORIGIN
        1 gtattattct acctgcttca ataaaaattt ctccatcata atattgagca aattctctaa
       61 ataactcttt agtcaaccct tcaggcataa actctatcca tgatttctca tcaactaatt
      121 gaataaattt ttcaatatct atatcctctt tgagattaac attcattcca taaatcatca
      181 ttggaattcg aattgaaaca cctcgaagaa ttgaaatcat tgccttacgt tgttttcgca
      241 aattttgtat cctttttatt aattcttctt cttctaagtt tctttctttt tttggtttct
      301 tttctgcttt accagctttt tcaaattctt cttgatttaa tccattttta ttaatatcta
      361 taaaatcttt actttgagcc tcagtgtttc caacaatccc ttttaatttt ttaaattttg
      421 ataaatcatt attatttaac attaataatt tatcattata caaagaacta tcttcgaatc
      481 cattattcac tgctttctct gcataaacct tttttaattg agttaacata ctatccacac
      541 taaattcttt cattccattt ccagattgac caagaaccgg taaaaaatta agcattctct
      601 gtagcttttg tttttgttcc gttgtattaa ttttgccttt cttattattt aaaccaatac
      661 tttcactaat aattttcaat gctctgtctg gagcaaaatc aaatacataa gcatttttct
      721 taattcctag tttttcatga ttaaatggcg tttgagcacg aaaagcagct tgcaaataag
      781 aagtgggact ttctgtgtta gataagaaaa atacgcctgt ccattcggga atattcacac
      841 ctgtagttag ttttcttaca gttaaggtaa tagttctagt agttgaaggg tcgctaccta
      901 tcgcatacct aactttattt atatctgatt cttttgcgta tttttcgtcg ccatcacgaa
      961 ctatattaac aatttgatac tctttaaata cttcgtgctt attcaaaagc aattctaacg
     1021 ctcttgcttc ccttactcca gggagtaacc ataaagtatg tcttaactta tctcgaaatt
     1081 ctttttttga aaatggaaag ttattattag tgttttcagt tgttatatag tttaaaaact
     1141 tttttatctc tttttcatga acaaacttat caatgttatc gtcatctacg cggaaaaatt
     1201 ctttgaaatt aaaagccctt tcttcgtcca aataattaaa cttattcgta acatcgaatg
     1261 tatacataga aactcgtgga agaccagaat atggattagg ttcatcaggt ttatctattg
     1321 accaacgtat ttttgcttct tgttccattg tatagtccca agtaaatata ttatctttat
     1381 catatttatc tatcaaattg aatggggtac ctgataattc taaaattttc gtgtgtgttt
     1441 ttttaaggtt attttttaca tttttagcaa ggtcagtctc attaccttca tgtgcttcat
     1501 caattatgat taaatcccaa tcaatttcaa ggaatttttc gtttttatca ccctgtttac
     1561 ctccagccca agttgatcct cttagatctt ggatactcgc aaagaaaata aaaggctttg
     1621 tggtattgac tacgttattt aaattaatac cttctttaga attggatcca tatatatatg
     1681 aattatcttg aaatattttg ccaaaatctt caaaccaacc atcacttact actggtctat
     1741 gtgtcattat taatactttt tgaaattttt cattttttat taactgtaga gctgataaag
     1801 ttttaccaaa acgcatcttt gcattccaca acatagtatc tttattttta aatacttgtt
     1861 gtgtttgttt aatagcctct tgttgctcag gacgcaattt aatagtcgat gttttatggg
     1921 caccaacata ttctgaattt aaagctactt ttccttcctt aacagcattt attgcagctt
     1981 ttgccacctc tatgggaact ctaaaccatt ctgaaggcct gccctcatta tttttttcag
     2041 gttcaattcc tgaacgtttt aatacagcat ggacatccct atctgagaaa aatttcttat
     2101 tgttatcaat agctaattgc gcccaatcaa cttgataagg taataaagaa gttgtcatat
     2161 attgactaat acgctttttt gcatgtaagt gtaaataatc actattaggt ctgaagtctg
     2221 cttctaaatc atctggtaca gaagcttcac ctattttctc caaaccatta aatgtaggat
     2281 aatccccatt atcattttca acactagtaa cataaatgaa ctttctctca aaagtttcat
     2341 aatttgcttg ttgcatttca tcaaatattt ctggatacac attaaatctc ttatcatact
     2401 ctttttttat gataaatcta aaaatacaat cgatatttat taatgcttgc tctgcttcct
     2461 gtgtagttac aagttccccg tgagctgctt tattcccagc tattcttatc tgtgtaaaca
     2521 atttctctat agattctgaa ataactcttt cttgctttaa ttcatttacc aatttataaa
     2581 tttttttatt tttataattc ggtaaagttt tcttagcaat ttctttagtt attgtttccg
     2641 catacaacct tgttctaaaa agtacagtat ctggtttttg agccaaaatc cctctataaa
     2701 aatgaacatc ttcgatcaat tttaaatcag gtaaattcat aaattcttct attttcattc
     2761 catatttagg taaataatca aaatatttag tcttcattaa cttcctccat ctcctcttta
     2821 tacacatcta ttatttttga tgggacgtaa tgcgcttttg atactgtatt tttttcagat
     2881 tttagcaagt cgtcaaaaaa agaaagttgt tcactttctt tttttgatgg agaatcaatt
     2941 ataggttctc ctaattcttt agaaatacct tgatatattt catctaatgt atattctgta
     3001 cgaattattt taataatttt gggttttcta tctaaattaa tagcagtcca ctcatttata
     3061 atgatcggct tgtcagcatt tgtatatcga gttaaaaagt taccttgaga aatattggta
     3121 gcaataatta atttagcact atctaaaact tttggattca tataactttt tccgtactta
     3181 tttaattgcg cattatattt ttcgtaaaaa acttgaaata aattcattgt acaattttga
     3241 gcattatctt ctaataattc tattccatat atagtactca acgctaataa tgaataattt
     3301 tcatattggt ttaaactttc attatgtttt tttgcaacca tatctaactt tctttccaaa
     3361 ataacaatta aaaatgctcc ttccccaact gcaggttcta aaaatgtact agttaaattt
     3421 tcacaacatt ctttaatgcc tggtgaatcg agcattttgt ttactatttt cctaggagta
     3481 aatacttctc catgcttttg cactcgagat ttacttttaa taatgatttc actcaaaaat
     3541 ttcacctcta tttaagttta aatataatat aattatacat caatacattt taaaagtgcg
     3601 ttattttaaa taattttaaa gttacttaaa ttaattcact acatttatta aatcaaaaac
     3661 cgcatcactt atgatacatt tccccttact agttatttta ctaaaaaatg agcccattac
     3721 ctgagctcat tctaaataat tatattaata gctgccaatt tcttctttat caataaaatt
     3781 aaaaatagta ggtatttctt gtgtggattt aatcttatca tagttttcaa atacttctct
     3841 ttgtgaactt ccaaataaaa agtcaaattg atctagatat tttttactac gaaatttatt
     3901 tattaaaata ttaatagttt gttgctcaag cgtaggccat ttactatacg acaaaactcc
     3961 atgccacgtt tcatatacac tatgaatatc tttttttata agactttctg tatataaaat
     4021 tacatctgca tcttgaacct tttttaaatc cttcccttca aagtatattt cggctaacat
     4081 ttttttgaca ttagtattat atgaatattt ccttgataac gcctggggat ataaacttaa
     4141 tatataataa tttgcttctc ttctactaaa gtgaaattta gcattcaata aatctttcaa
     4201 aaattcattt gctcctgatg ataaagcttc acttactagt ataagaaatg aaaaataatt
     4261 aaaaatcctg gtcattggat ttttaaattc ttcttccgta agcattaagc acctattata
     4321 atgctctatg attaattccc taaaataaaa gttatcattg tttagcgcat acgtaataag
     4381 ttctttccaa gtatcaaaaa cctcttttaa agtcattaaa tcatctttat tatattcctc
     4441 tacactattt tctatatttt ctaaagtttt ataaataatg tctaaagctt cttcaaaatt
     4501 tctcgtttca ttataacttt tagataaagt taattttttt atcgcttttt tcaggtcatt
     4561 gtgatcttga ttataatcgg gtacattacc aattttcggt ttttcaaata atggtttatt
     4621 atgtactttt cttgcaattt cttctgcttt ctctatatct aattcaatat ctgtcatatc
     4681 aatagcgaat ctagtattac aaaaagttgg caatgctggt ttgccattgc ttaaaatatc
     4741 taaaaaaaca ggtataaact tactatctct ttgcttatca taaatttgtg aggtaattat
     4801 tgtgctttct tttccgactc ctccttctct atcattagct ctattaaaat actgaaaatc
     4861 gcttaatata ataataaaat caatcgtctt gtcattgacc atagactcca taaaataatt
     4921 caagtcatct ccttcagtac aatcccaaac atctaaaata acatcaattc catggtcaac
     4981 tctcaaattc tctgctattc tcacaactct ctttaaatgg tctttacttg ttctagaata
     5041 tgaaataaaa gcttttttgt tcacattgtc ccactccttg ttcaaaaaca tttaatatat
     5101 agtctcattt ttcttttaat acatttctaa atttagttac atgtctatca taatctccgt
     5161 tttttaacat ttcataaatt accatttaat aaagtatact cgaaccatat tcaatctgca
     5221 gtctgatatc agctaattgt tcaaccactt tttcagaggc aatagcccaa ccaatactaa
     5281 tagcaagcgc aattgatttt aaaaaactac ttatatgaat aacattgtta tttgtatcta
     5341 acgacttaat tgatcttact agtatttcat caaactatat acctatataa atgtcgtctt
     5401 ctacaattgg tatattaaga actctactgt agttaaccat atctacccta attttctctg
     5461 atattgacag tcagttggat tattgataga aacaagctga taaaaataat gatttagaaa
     5521 caatgtaaaa gctgattcaa atcgagaata taaagttgtt agtaatgaag ttaatacaca
     5581 agaacagcat acacgggaaa aatctattaa ttcatcaaaa aatgaaaaat tataaatcgt
     5641 gaaaatgttt tcaactattt gatgattgaa acagattcca aaccagaaaa cgattcaagt
     5701 aaaattaaat tccagagtct tagtataaag agaggtattg gttaataact gcaaataata
     5761 aaagtaatgc aggttcatac tcattgaaat tatataatga tggaacagtt gaattagaat
     5821 taaaattgca caaaacagac tatagatgac acatcatcta tggtctgttt tcattttgag
     5881 acctgtctaa atttaaatac cccttgtttt ttgtatttaa gaaaaaggat cgataattta
     5941 aaagtacaaa aataagcata tttcacttaa gaacctctta tttccataaa gtgtaattag
     6001 tgtactttac aaagtgaatt aacgtgaaaa tacttttcca tttaaactat actttattct
     6061 gtatttttga aagctcttgt tttaatattt ttttctttca agaatttttc aattttatct
     6121 tgttctttac catttacaat tttactgtca tatttaattt catcaaaatc ttcagttgga
     6181 atttcaccat cttcagtaag tttattcata gttaaatcaa tttgtttgtc taaattttca
     6241 aatactttat ttgaagtaga tatatattta cttattttaa atgcatactt gttgtatcct
     6301 tctggcaatc tattattttt tatataatta tagaaattat tatcattttc tctagttaat
     6361 ttatttaatt gcttaatttc tttgctatct acttcactta gcttctcctc agagtccaat
     6421 ttatcttggt aatattcttt cgctttactt aaatcatcat cactgtttaa gtataattta
     6481 attgagtctt ttatttcctg ttctgaaagc tgagaattgg tagttttatt atcaaagatt
     6541 tttgtaggta aactcttttt ttctactttc ttataactat tatcagcttt atttatatca
     6601 gtgttatgcc cattagaaca ccctgtaata aatatcaata aaaatagtat tcctaatatt
     6661 aaaagttttt tcatcataaa ctctccctct taaaggtatt taggttccat ttcaaataga
     6721 aaataatgaa tttaaaaaag ttttttacaa aatagtatcc tataagtcct aaaattactc
     6781 ctaaaattac tccttttatt acttcgaaaa catcgcttac tgtaattgta tcgaatccat
     6841 ttataattcc aattataaat aatattattg gagaagataa cattactggg accgcaataa
     6901 tatacgctat tataaaaggt agaagtaata agaaaataaa tagacttaat cctattacta
     6961 taaaattgaa aacgcttagt cccataatag aaaaagtggc aataaaaata ttttttatac
     7021 ttttttcttt ttcaacaata tttaaagcat tcatagcatt tatttccttt gaaatatcaa
     7081 taggatcacc taatcctcta attatttctt cgtcattctt tttgtcttta taaccactaa
     7141 taaaatgaga ctcatattcg tttaaaatat cttttttatc ttctttgttc attcttttaa
     7201 tacatctatt caaagttgca atgtattcat cctttgtcat gaatatcact ctctttcata
     7261 aatgagttta ttgattcagt gaacatattc cattcttccg ttaatttttt tagtctttcg
     7321 ttacctttca ctgttattgc atagtattta cgtgaaggcc cttcccttga gggttcataa
     7381 taactattca agtatccttc tttaacaagt ctacgcaaca aaggataaat tgtaccttct
     7441 gatattgcta tttttttagc tataatttga attaatgagt aaccatattg gtcattatta
     7501 tttataatta ataataccaa taactccaat gctccttttt taaattgaac attcattatt
     7561 aaatggcctc cttatactga ttgtagggta tataaaacac tactatgcaa tatataatac
     7621 cttgccttaa acaataggta aagagctaag agataatctt aataaatttt ttataccttt
     7681 cactgttttt caataattct ccgtgaattc ctttgaaaag aattttaccg ttttcaataa
     7741 aaagtacctc ttcattttca tgtaactctt gtatgttatg agttattttt aaagtcgttc
     7801 tgttacgtgt aagatctgaa atagatttta agatttcact tttagattcg ttatctaaat
     7861 ttgaagttgc ttcatctaat aatataatac tagggttctt taaaaacagt cttgctaaat
     7921 ttattctttg cttttctcca ccagataatt tatttccgct ttctcctaca taactattga
     7981 ggttatcaat ttgattcgtt actaatttat ttaaaattga gaaatctaga ctcttttgaa
     8041 ttttatcatt tgttatggtt tcttctctta atccatataa taagttatct ttgattgttc
     8101 cacttataat tggtatatct tgactcacta atccaatatt ttttcttaaa gaatgagtac
     8161 taatttggtt gatatcaacg ccatctacgg taatagtgcc tttttctaca gtataaaact
     8221 tttctaataa atttagtaat gttgtttttc ctgagcctga agggcctata atcgtaagac
     8281 tatttccctt attaagtgtg aatgatatgt catcaagaat tttcttccca ttaaactcta
     8341 ttgttacatt attaaatgat aaattattat ttaatctaaa atcatatgta tattgatcat
     8401 ttttcctttc tacatcttca ttaataatct tagttaaact tctgaaagca ccgtttgctt
     8461 tgtgatactc tcctataaag ctgcttatag aactcatagg agacattaat tgaaacgaat
     8521 aaattataaa tgcaataaga gtgcctaact ctaaagtccc attttggatt ctatatgccc
     8581 cgtacccagc tataactaat aatccaaata ttaatagaaa attaactaaa ggagaaataa
     8641 aagccataac tttactttca tatagattca ctttaaataa attattaata tgtcttgaaa
     8701 taatattttt ctctgaacac tcagcagtgg atgcttttac cattttaata tttttaaagg
     8761 tctcttgcgt ttgggatata aaattagata tttcatattg ctgtttctca cctgtatctt
     8821 ctaatttctt catcaaagga aagataatcc caaaaattaa aggggctatt aataatataa
     8881 ctatagtcaa ttcccaatct aaaaatgcta ttaaaacgat agcaccgata accatgataa
     8941 ccccattaat aactttcgga atatgaaaag ttattaaatc ttttattact tcggtatcgt
     9001 ttaccaatct actagataat tcaccacttt tatatttatc aaaaaatgat attggatagt
     9061 gtattatctt attatatata ttctgctgta agtctttaat tattatattt ccaaattttg
     9121 agataatata ttcatttatt ccttcaatta atgatcttaa gattaaaaat gaaaccaacg
     9181 aaataataac aagtgtattt atccgattat tttcaagctc atttatgatg ttttttatca
     9241 atataggaaa atataaagaa gctattgtaa aaattaatga taaaaaaata attaaagcta
     9301 gataaatttt tttcttttta ttgttgatag taagcttaaa tactttatat acattcaaaa
     9361 attatcacct tcataaaaag tgagacaata aagctgtata gaacaccttc attgtctcta
     9421 tttttaaaaa ctaactctaa cagaaaaacc aacttgcatg actacttttc ttacagttct
     9481 gacttcttga agattttgct tttaattgaa cttcctttga aattgtttct tgttgtaaag
     9541 ataatacttt attcattgac attctctcct taattataat ttagcaaata aaccaacttg
     9601 cgtgactact attcttacag ttttgacttc ttgaagattt tgcttttaat tgaacttcct
     9661 ttgaaattgt ttcttgttgt aaagataata ctttattcat tgacattctc tccttagtta
     9721 taatttagca aataaaccaa cttgcgtgac tactattctt acagttttga cttcttgaag
     9781 attttgcttt taattgaact tcctttgaaa ttgtttcttg ctgtaaagat aatactttat
     9841 tcattgacat tctctcctta attataattt aacagaagaa ccaactagta ttacttgaag
     9901 gagcacatcc ccaactagca cttgattgtt ttggacttgg cttttttttt ccagacttac
     9961 ttcgcatttg ttgcaaatct aaaacttgct tcattagatt tcaccccctt tttatgctat
    10021 ctaaatttaa tattttattt atattaaata gcggtatcca agaaaaatgg gaaccactta
    10081 taatatcttg aataactgtc aataatccag cagcccccga catgaggtct gatgacaccc
    10141 tgaaacaaga atctcccggc acatacaaac aatcatctgt ttcaattaaa tataaattca
    10201 gcgtaaataa tgatgaattt actaaatctt ttctatttaa atacttatcc aacaagtgac
    10261 taattgctaa tatacctgta gctccttgga atagtcctgc attataaaat gtcttactat
    10321 gagcaatttt ggctatacct tctagttctt ttatccattt attactattt tcaatacttt
    10381 ggatttcaag catagggatt gctaaaccac tacctccgct agataagtag ggaagtattc
    10441 gaaagtcatc atctgtttga aataagccat cctcatcaaa caatgttttt tccaactctc
    10501 tatctaacat ctttttagat atatctaacc atttcttttc accagtggct ttataaagac
    10561 tagacataaa taaagaagct ccagaccaac tagtaagaaa acctttatct actatgtcat
    10621 aatcaaaagt ataaactggg gtatcttttt caaaattatt ctctagtaat tctgctattt
    10681 gtttacattt gcttaggtag taatcatttt caaattcata gtaaatactt aaaaaaccta
    10741 ggcctaaacc acttagacct gaagcaatag atatatcatg tttattagaa tcaatatcta
    10801 ttgtttcaag taatttttta gctttatctg tatatttagc ctcaatcaaa acattacata
    10861 tacccatctt tcctgtatat agaccatcct ctaaattaat caaaatttct tcttctatat
    10921 tttcaatcca cttattgagt ctctcatccc actcattagc tcttttaaga gccataatta
    10981 ctccgaatcc tccggttaaa acattccatt ttccagaatc catttcatat tgtcttatgt
    11041 ccccatgtat taataattct tcattattca aatctttttt tatggcattt attaatttct
    11101 ctttaattga aattaaatta aaatccctaa ctaaagtttc agtagaatct attaattgtt
    11161 tcataggtct agcattatgt cttttacaaa ttttttctat ttttttaata atattcaaag
    11221 cttctaatcc aaaaactttt tcaatccatt tagtatgtat tttatccaaa ttgtgagaga
    11281 tatcctgtac attacctata ggaataaaca tttgtttagc aattcttaac acagcaaacc
    11341 agtcactttg ttctttacac attttagggt ctcctatgaa acctggagtc attacagtag
    11401 caatagaatc ttcaacagac cctgcagttt caaaatcaat caatcttatt ctttcatcag
    11461 atgtcaccat aatgtttgct ggttgtaggt ctccaaatcc aataccaaga ctatggattt
    11521 cttctataga tttaactagt tcatttaata tgttaactga ggattttaca tactctttat
    11581 ttttttcttt tgaagaaaaa gggtaattat tcactatcca aatcgttaac gaatttcctt
    11641 ttatatattc ttcaacgata aatttatgtt cccatgctac gaaatcatca tatacttcaa
    11701 ctggataatg tgcatctttt aattttttta aaatttctcc ttcattatga attcttttaa
    11761 aagcatcaac atcatccaaa ccagaagctg tatacggtct tccttcttta agtataactt
    11821 ccccccattt ttcatggtca gctaaataaa ctccacctcc attactaaaa tgtaaggctt
    11881 cttttatcga ataatcatct atacaagttc tctcgtattc tttttctgac tctaaatcca
    11941 tcttttttat ttgactaggt tcttcaataa aatcaggtac agaataaaat ggttttcttt
    12001 ggtcttctat taaattccca ttcaagtctt ctatcgcatc cagaatctct ccatttttgt
    12061 ataacgtttt aggcataaat ccgccatatc taaaataaat attactttta taccatcttt
    12121 tatcgtttaa aatatatggt cctttaggta aatgagataa tttttcttct aatttcagca
    12181 ataaatctaa aaattgatca gtagatgaag ggtatatagt tataaattta cctgaagaac
    12241 tccgatctcc atatttagaa tcctttaaca ttaattcatg catgcttttt acatatttga
    12301 atgatacatt ttcattaaac ataagttcag caactgaatc tagtgtttgt tttgccgttt
    12361 ttaattgtgt acttatatgt attttccaac cttgttccgg taaagtttga ttgtaattag
    12421 atatatttat ccaatggtct cctgatactt ttgtgaagtt agatggaata taatctaaat
    12481 ttatataccc tacattttga ttagtaggtt tagtatagta acaactatca tttatgtatt
    12541 ttacatacct ataatccata attttcatct ccaaatccac accaactgaa gtttacttca
    12601 gttggtgtaa ttaatcctta tctattttcc tccagggaaa acacagaaga taatgctagc
    12661 actactttgt tttttacaca taacacttgc atttgatgct tggtgatttg atgacttttt
    12721 tgaacgcata ctttgcaatt tcaagacgtt attcttttcc attttttcac ctcctaattc
    12781 aattgatgat aaataaattc attattgtag atagaatttt ctgtgaattc gaacatttct
    12841 tctatatagc gtccccaata aggtgcgaat gttaaccttt tctttttttt gaatgaaagg
    12901 ctggtattag atatttgata ttgcttatta ttacattcgt aataccaagg agagccagaa
    12961 agccctgaat ttgattttaa ttttatgcct atcatacttg atttatatat atcatcgtta
    13021 aaaatatttc tttcataaga aacaacttta tttttaaaca aacctctttt ttgagatata
    13081 attaatactt ttgctggctt agtcacacaa aatttaggtc ggattttatc atatctatgc
    13141 atatttattt tttcaggaaa taatatagca gtatcaaaat ccaatatacc ttcattaatc
    13201 catcttttac ttaaaataat gtaatcaata tttatttttc cacccaaata atcaaaaaaa
    13261 tttacttttt ctgaaaactt ttcgctatac cagtcataaa cactgtgcgc tgaagtgata
    13321 attaaaggtt tgtcttccca aaatatcact gaagcattag aagtcatttc ttcaccattt
    13381 attagggttt ttataatacc gacatttttg gttgttattt ttcgacactc cttactcttg
    13441 tgcaacataa tatctattac aaaaatacca cttacccaat aatatttcaa taaaatttat
    13501 aatttttttc taaaatttaa tatttataaa acagtgttaa gcaaagtacc ttactatata
    13561 tagtaggtgc ttaaacactt tagattaata aattataatg ttaatgggta acttattaaa
    13621 aaagactaac tgaaagtaat aacagttagc ctttttaaca aaacaactaa taagtagaat
    13681 cttataaaac cgcatcattt atgatacgct tctgcttatc agttgatgtt gcggtttttc
    13741 tagatatgta actcaagcca ttaaagttat aatcagtttt tcaataaaat tgttattctg
    13801 ttaagacttc ctataattta aatattcata aaaaatattc tcctttacaa tagtaagtta
    13861 tttaaactat tgattaagga gaatatataa ttcttatata aagaatattg ggttagtttt
    13921 aaaataacag taatccctac taatatttta tctctaacca tttcatcttc aagaattaaa
    13981 ctattaacgt gctttcaatt cattttcggt cagccattta tgatttttga cagtttttcc
    14041 attatcttta ggtttgtaat caaccatgta aacaggggtc tctttcacat catctatatt
    14101 cgctgtcgca cctttcattc caggcatatg atctgcttct aatttaacag tatcgccctt
    14161 gttaaaccca tttttggggg catctttaat ttcttcattt acgacccatt tatgattgtt
    14221 tactttttta tctccatttg taggtttata agttacaaca taggcatatg ttttataagc
    14281 gtcttttact gtggcttctg catccttcat tccaggcata tgcccagctg taatagtcac
    14341 tttatcacct ggtttaaact taccttggtc agttgatgtc atatcttcag gagccttact
    14401 ttcatcatta tgtttcatat ggctctcact cttttggtct ttagtgtctt catttttttc
    14461 atcactattt gaacatgcag ataacgctaa cattgagcct aataaaataa aaattaattt
    14521 tttaatcata gtaacgctcc tatcttttat tttaatttca gtgtaaaggc attaattgca
    14581 acgataatcg tacttagtga cattaaaatg gcacctactg caggtgataa aatcaagccg
    14641 ataaatgcca aaacaccagc agctaaaggt acagcaacaa tattgtatcc tgctccccac
    14701 cataagtttt gaaccatttt tctcatggta ttatttgaaa gggtcaagaa atggataata
    14761 tctgatggat tacttttaac aagaattata tcacctgaat cgactgcaac atctgtgcct
    14821 gcaccaattg ctataccaat gtcggctctt ataagactcg gcgcgtcgtt gataccgtca
    14881 ccaaccatca ttactttttt accgttactt tgataatctt gtatgatact ttctttatct
    14941 tctggcatta gttgtgcatg tacatcacta atacctaatt cttttgcaac agcattcgct
    15001 acttcattat tgtcaccagt aagcataact ggtgtaatat ttcttgataa taaatcagct
    15061 accatttgtt ttgaactttc tttaatttgg tctccttgag cgataatgcc aatgacttgt
    15121 tgctcgtcaa ttaaataact gattgaatta ccttgttgag ctaattcaac aaacaagtcg
    15181 ttatcatatt caaatttata tttatctaga taagagatat tggttatttt atatttttta
    15241 ctatcaatgc taccttctaa tcctatacct gaaatgttat taacttcttg cgggctagca
    15301 tatgaaatat ttttactttt cgcaaaatcc acaatacctg tggctaatgg atgattagat
    15361 tggctttcta atgacgcaaa aagacttaat attgtatcat tgcttaagtc atctttaaag
    15421 ctttcataat aattaactga aaaattacct tcagttaaag tgcctgtttt atccatcatt
    15481 acataatcaa tatattgagc tgtttctaca gactctctat ttttaataat taaaccatta
    15541 tgtgcaccga ttgaagtaga acgtgcagta actaaaggta tcgccaagcc taaagcatgt
    15601 ggacaagcaa tgactaatac agttacgagt cgttctagtg caaagtcaac atcattttga
    15661 ataagcatcc atacgataaa agaaattacg ccgacactta tggcaaagta gaataaataa
    15721 cccgctactt tatctgataa caattcagct ctagatttat cattttgcgc ttgatgaact
    15781 agccccataa cttgagaaag atagccgtct tctcctacag ctgtaacctt catttgtatc
    15841 gttccggacc cattaataga accgccgatg acgctgtcat tttgattttt ttgtattttt
    15901 ttagattccc ctgtgactaa tgattcatct attgatgttt gaccgtgaac aatcatacca
    15961 tctgttggaa tgctttctcc agcttttact tctacgatat catcgatcat gatatctgat
    16021 attttaactt cttcacgttt gttattgtcc atgattttaa tggcactatt aggtaagagt
    16081 tctgccattt tcttcaaagc atccccagca tttcctacag cattcatttc tatccaatga
    16141 cctaataaca tgattaaaat taatgtagct aattcccaga aaaagtccat tgtatggcct
    16201 ggcgtactac taatgttatt catgtaaaaa gcatacaagc tataaatgta agctaccgaa
    16261 atacctaaag caactaaggt catcataccc ggttttttcg caacaatttc atcttttcca
    16321 ccagataaga atggtttacc accataaaag aataaaattg taccaagtat taagacgacc
    16381 cattcagagc ccggaaatgt gaattgaaag ggtaatttaa cccccatcat tggtgataaa
    16441 ataattatag gtattgcaaa aatgagtgag acaaaaaatt taactttaaa attgccatga
    16501 tggtgatgtt cgtgcccatt atgatgacta tacgcttcat ggtgatcatg atgttcatgt
    16561 gcttcatgat gaatttgatt agaatgattc atgtgatttt catgattaag attatgttct
    16621 tctccattat ttctcaaatt aagtccccct atttacgaaa atattatagt aattatggtt
    16681 ataatataac acataccccg tataggtata aacgcttttg tttttaactg atattacaca
    16741 gtcaagtgat gtgctgttat ttacaataac ccaaaatata taacaaggaa attagagtaa
    16801 aactaaatgg aacgcatacc acaaaatatt tttataattc atttatacta tgattcacaa
    16861 tgagttatgt ttatattttt gttaatataa taaattatct atattaaacg tctcatagtt
    16921 attgagctta tttatcatat gtctctgcta tcgtttgttg atgttttttc acatttatat
    16981 atcgtgttga aaagcaatct atatacatag gaaaaagaaa gtatcacata tttaggcact
    17041 gaccccttaa agtgggaatt tagtaaaaac acgattgcta ggctgctagt tttctaaatt
    17101 ccataggaga taagtagcct aatttttatt gaattctaac tttatttttt gttgagtttt
    17161 gtgtcagtat aaccttaata tgttgctagt tgattagatt tgtttattaa agcaaaattc
    17221 aatagtgatt ttgatttgtt aggattatta atctgaggaa tgagagtaaa agtacgcaat
    17281 gcattgctac ttttagttaa acatctttta atcaattaca tctataaaaa accgcatcac
    17341 ttatgatacg cttctgctta tcgggtagtg atgcggtttt ttgtaattgg tttttcgtac
    17401 atctagataa aacgatatat tactactgta aacactttac gtctaatatc aactagtatc
    17461 ataaaagctt attatatata caaaaagctc tatcaagttg tgggacttga tagagtatat
    17521 tgtctgttac ctttttacat aaaatttttt attgttgctt tggtaatttc aattactatc
    17581 ccatttcata agatattcat attcttgggt ttctgcttca aattccttag atcgtatttc
    17641 aaattgatgt tttgtataaa aacgaatggc tccttcattc ttctcatata catgtaaatt
    17701 aagtccatta taatcgcttt ttaatctttc caataataac tttcctatac ctttattacg
    17761 gtgtttttct gtaataaaaa cacctgcaat atattgctca tataagccag caaatccgac
    17821 aatttgatta tcatcataat acacgtaaat tgttgaatct gggaacattt ttttcacttt
    17881 acttaggtta tcaatccaat actcacgttt tataaagtca tgcgcatcta aattagaatt
    17941 aagccatata tttgatatct tttctattga ctcagaatct aaattgtcta atttctttat
    18001 cattacatac ccctccttac ttccaaattt ttatccgcag ccaactaata cctgctttga
    18061 tatttggaag atttctctta tctcataatt ctattcagca ttttcaaata ggtattaatg
    18121 taaactgcac gtcgataaac atcataactt tcttattgac tagcaaataa tgttcgcctg
    18181 ggttcactat cagtccgaaa acatggtgat taagatgcac aaacacttgc agtgacatac
    18241 tttatagaaa tacttataaa agagaagcat ttattatatt aagacatata agcccgtcac
    18301 acctataaac atccttttta gctatttata tgaagcacca attccattaa ctgataaaag
    18361 tattctgttc tatgagtctt atttaactat gaatcaatga ttactactca ccaccatcta
    18421 taactcgatg gatcatggaa atcaacatcg ctttctttca tttcatttag taaatatttt
    18481 actatttgat catggtttct atctcctaat gctttctcaa ctttactgga gtctttcaac
    18541 caagtaagtg tctccttata ccacatcatc tcttcaattg ttgcattctt tagcttatac
    18601 tcattaatat actcggttaa cgcttttatt tctttatgta atttgtactc actgattagt
    18661 gttttaatat tattaaattc cgattcctta ctttttctta attgttcagc ttctttgcgt
    18721 ttgcgttcct cttcgttctg cttttcaatg tattcaagct ctgcatcatt caataactgt
    18781 ggtaattcaa atattctctc aaaaattttc ttcattaatg tgttattgtc atctgtacca
    18841 ggatagtctc gattaatacc atagacgtta ttaccccaag gatagactcc aacgagttca
    18901 gccttgaaat agccagtatt gagataatca taagaagaat aacgattatc atctcttttg
    18961 actcttttct tcttttcttt aaaccttaat tttatatgaa atacattcaa ctttagatac
    19021 attaggtcac ttttcttcac ttgtttgtct ctacgagcta tatgaataca aatatattct
    19081 tcatcaacac taaccttaaa atttaaacat tcgattgctt taaataaagt atcacaaagt
    19141 ctataaaagt ctggtaatgc ttcttttgat atatgtgatg tattcaaaac tttctgtggc
    19201 tctgagcgat aataacccca aagcttcatt tccgcttccc tttctcttct tctttcagat
    19261 gtaaggtagt ttttatgttt agtgacgatt ttatgatgac gtttaacctt atctggtatc
    19321 ttcaattcgg tatatacatt ataaatttct tcttttttat catcgtcaaa gtatgaccat
    19381 ttatttgtta ttttagtttt ttcgctcagt ttctcatcaa gtttaattga ataatcttca
    19441 ccttctatag gttctagctg accaataata cctcttctgt aatcatacaa atacttagaa
    19501 ttgggtaaag gaatcttatg gatttcaatg attttcttca aatcattaaa ctcgatatta
    19561 tgttcctcag caaatgcagt acgagatttt gtccataact ctctataaat atcaaagcga
    19621 ttcatttcca tctttcacac tcctaacgaa ttgtatgatt acaatagatg tagcatgtga
    19681 atatataaaa agtcgaattt tctcttccat caattttcat atcatactct aattaagtaa
    19741 ttgcattatt agctattgct gcattttgat ttataatact gataatctat atacaaattt
    19801 atcttcaagt taaatagtaa ttatttagta aatccacctt cactattaat aaatctgtcc
    19861 aataatccaa aatgctctat cataactaag cagccacaat gcaagtaaat tatccacctt
    19921 agccataata ttaacctctt tcatgtgtat cttatatcac ttttccgcaa ctttacttct
    19981 tcattcgtaa ttgctttggg tattatatca tcttatattt ataaatatat tattaaatcc
    20041 acttttgaag ttcttcttta ttttctttat ttagaactcc actacatatt gcacttacat
    20101 gttgtttatc tttattataa attattccaa ttacctttct tattgcctta tgaacttctg
    20161 taacagacaa ttcgtaataa tgattatcta taaatgatat tccgtgagag agactattaa
    20221 taatatctaa gctttctttt aagtctccaa ttttttcatc tgctatatta taatattttg
    20281 ataattcagt aaccgaagca gctgtcgcgt attctatttt ataatggctc ctagcatgag
    20341 attctaaaat aaacctcact ttatttgcat atttaatata attatctatc ttattgactt
    20401 tacttttacc ttttatagca aatgacatta cttcgttaaa aactgtccta taataatcac
    20461 tataattgct taactcttct ttagataatt tatttacttt actaattcca tcaatttttt
    20521 caatatacca ataggaagtt tccttggtat tattctttcc tttaaaagca aaattatgga
    20581 aatcaaaaga ggaatgtgta aacacaaaaa cctgtttatt tacagatttg gaaagctcaa
    20641 taaattgatt gataatttta gttaaatgat atctattttc tgtatctaaa ctagtaatcg
    20701 gatcatctat gattatatac tcaatatttt ctttcatctc actatctgct atcataaata
    20761 agttataata aaaatgtaag aaacctatta atcgtttttc cccctcactt aaatcaacta
    20821 atttaagttt ttcttttgtt actctatgta aaactctata actcttaatt tcaatattag
    20881 gctctaattc aatatttata tcaagtgttt caaatctctt atttactatt tcactaaact
    20941 gtttcaagtt agatgagttt gttttcaact ttgttatcca atcattattc tctgttatac
    21001 attcttctga ttcttttatt tgtttgctat tactattaat gttagaaatt tccatttgaa
    21061 tttcttcatc attttttagc ttcttgccaa tccatgattt cacaaaatcc gcaattgaat
    21121 ctctaatatt tttatcattt tgtatttctt tttttaaatt ttcaatataa ctattaacga
    21181 tattatctat tatatttatt gattcccaat tatccatagg gtactcaaga tgttcatatg
    21241 tctttacttc cttatcttcc aatatatgta atagtctaat aagttcttct ttttgatttg
    21301 agtaatctac taagtcaata tctatattta aatcttctaa attacttaat gatttattta
    21361 tttttgtttt ataattattt aaatttccaa ttaaataact aaattcattt tttattctta
    21421 catctatact ttcttttagc aattctacat caaatatgtt accgcaaaac tcacatgttt
    21481 cctcttttga ttgcatgtta tgaatttcta agccatcttt tagccattca gaaactttgt
    21541 aacttacgct acttgtaggt ttaattactt ctttcatcag taattttacc atattactaa
    21601 actcatcata atcaaaagct aaaatagggg tttttatatt atttaataag acttctttac
    21661 tggttattct ttcttctaat tcatctaaag attctatagt cgtctcttca attatatcgt
    21721 tagtattttt cttccaacta taaaaagcat taacaggatc tttgtcagca ttcctcttct
    21781 gcttaaccac attactaccg atttcaaatt tttttctagc ttcatttagt ctaatattca
    21841 ttttatcgta aattcttttt tttgaatgca taatttcatt atctttccga gtaataaaat
    21901 tttctaaatt atttatagcg ctatttaaat gcttaatttg atcactatga tttatagatt
    21961 cttctccaat aaccaaactc acaccatcta tttcttcaac ttcttcaata ttatttttta
    22021 agtaaccagt attaaagata acgctttttt cattatctag tcttcttaac cattcactta
    22081 atgagctttt tccactccca tttcttccaa aaaatatatt tactttattc aaatcatctt
    22141 tactagtgta attatcaaat gatttataac taacattttc taatttattt aacatcaaat
    22201 caatcctttt tatatttaaa atatattata cacaatcctt ttttagtttt atttgtgata
    22261 cgcttcccca cgcataatct taaatgcacg gtaaatctgc tctatcaata tgacacgcat
    22321 catttggtgt gggaaggtca ttttactgaa ggataatgca taatcgctac ggtctagtac
    22381 gtcttgatgt aaaccgttgg acccaccaat aataaaggtg aagtcacttt gtcctctcgt
    22441 cattctccct tctatttctt tagctaatcc ttcagacgtc aacatattgc ctttgatttc
    22501 aagtgttatg acagttgact gaggttttac ttttgctaat aagcgctgcc cttcttttt
//
