LOCUS       NZ_CP021707            11368 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces sp. S063 chromosome, complete genome.
ACCESSION   NZ_CP021707
VERSION     NZ_CP021707.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S063
  ORGANISM  Streptomyces sp. S063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Complete genome sequence of Streptomyces sp. S063, a producer of
            anti-complement compounds and various secondary metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAY-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:19:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,905
            CDSs (total)                      :: 6,817
            Genes (coding)                    :: 6,244
            CDSs (with protein)               :: 6,244
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 574
            CDSs (without protein)            :: 573
            Pseudo Genes (ambiguous residues) :: 0 of 574
            Pseudo Genes (frameshifted)       :: 432 of 574
            Pseudo Genes (incomplete)         :: 192 of 574
            Pseudo Genes (internal stop)      :: 13 of 574
            Pseudo Genes (multiple problems)  :: 61 of 574
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:16:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7171745
            Orig. end                         :: 7183113
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021707.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Xinqing Zhao, Life Science
            and Biotechnology, Shanghai Jiaotong University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11368
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="25"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11368
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11368
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6368](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6368
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            193..1251
                     /locus_tag="CCZ36_RS32550"
     CDS             193..1251
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955794.1"
                     /locus_tag="CCZ36_RS32550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron ABC transporter permease"
                     /protein_id="WP_069739362.1"
                     /transl_table=11
                     /translation="MTFVDTAPGPVRRTLRAPGVRLGGLALLVAVVACAGLFAGRGVTP
                     DSVRAVLLGAGGDPTSEHIVLQLRLPRVLVALVAGACLGVAGLVLQSALRNPLAGPEVT
                     GVTPGAVLGAVTATGLGLAGWESPAAVVVAACVGGFAGAGLLWLLTGRDRGDPEQTAVY
                     GVLVSAVLAGLTAVVLLVAPGELGSVVQWLIGSTEGRVWQHWNLLWPWAAFWGAAAWLL
                     AGPLTLLRCGDEQAAAAGLATGRGRGAALVCAVALTAGAVSAVGALGFVGLLVPHLALA
                     VFGADLRVTLPGAALLGAAVVCGADAVAQLLSRLLATALDADRLTLPVGALTTCVGAGL
                     LLVVARRRADER"
     gene            1281..2135
                     /locus_tag="CCZ36_RS32555"
     CDS             1281..2135
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955796.1"
                     /locus_tag="CCZ36_RS32555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_128819187.1"
                     /transl_table=11
                     /translation="MSATESATPKAPDVVRAEGLAFGYPGRPVLRGVDLSIRAGELVAL
                     IGLNGCGKSTFLKLAAGLLAPSGGRVLLGGDDVARLPRRTAARRAALLHQSAPSVPGLT
                     VRQLVRQGRYAARGPLGMLREGDDEVMSRALADVGVTAWADRPVDALSGGERQRVRLAM
                     ALAQDAPVLFLDEPTTYLDLRHQLEVLQTVVRLRRERRLTVVMVLHDLNHAARFADRIV
                     ALREGRIAADGPPGEVVTRHLLAEVLGVEGRVGIDDEGGWPVCYPDHPLEPLQLLRNEN
                     HIH"
     gene            2204..2338
                     /gene="amiA"
                     /locus_tag="CCZ36_RS36270"
     CDS             2204..2338
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508296.1"
                     /locus_tag="CCZ36_RS36270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_006129278.1"
                     /transl_table=11
                     /translation="MEQNKVFSPIADQGQLAHLSATHSNALVENPFDDAVEADTAAEK"
     misc_feature    complement(2211..2225)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.28"
                     /tool="antismash"
     gene            2472..3440
                     /locus_tag="CCZ36_RS32560"
     CDS             2472..3440
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059073.1"
                     /locus_tag="CCZ36_RS32560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_128819188.1"
                     /transl_table=11
                     /translation="MTRSRLAPGAGIVTVPGAAPVLRTSGGEFLRIDTGDVTGEALVRR
                     LAGEETPDGETPGKETPGEESQTAGLARLVEAFEAGGHAVSTPPRAPLAGRTVHVVGDP
                     VLTGPMARCAGAEGAEVHSITPDRVAELARTTRDPRTEGRVAVVWCLDSPVPEGLWDAA
                     DRLPDRRIAWLRCHREGSHSWTEPLAAAPGDVTSRHVRLRRLAATPAHRELAAYWAGHR
                     TPDTGPHPTEASAALIAALLTADLIAWTEAEAEAEATGGRAGGSGRQPAGVPARRRLRR
                     VDLRDLTFTEHAVLPVPDVAPLPAPTPAGTRARSGAAEARP"
     gene            3437..5004
                     /locus_tag="CCZ36_RS32565"
                     /pseudo=""
     CDS             3437..5004
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059074.1"
                     /locus_tag="CCZ36_RS32565"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="CocE/NonD family hydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNTRTVSVLTPDGTPLATDVCLPDGGRPRPAVLIRTPYGRDAHRA
                     ELRGWAAHGFAALAQDVRGRHGSPGEWHPYGDHEKADGAATVAWVRAQAWSNGEVVAVG
                     ASYAAYCALVTALDGPDGPRDAVAEKGFATESPTPSSPPFPRSGSPRPRASTGGRSGCG
                     PGPAGGRPTATGTTPTRTRWGARWPTPPGCSNTSRSPAWGSGWPRVSGVNCLPGPGSGP
                     TGSAAASWRSAPRPAFRCSPSVALATPSPRTPWPSGAAGADRRVCCSAPGGTASPPTGP
                     RPPARVSTSAPCTYDGPAPRSSGDWIRPATGSSPSATAAVGTASTGRCPPPKPSAVGPS
                     RRPPVYGCSTEPSSTPTRSAPCAPTTSPSRSTAARPTAVCCSRRRCPAPSTWRGPP"
     gene            5001..6368
                     /locus_tag="CCZ36_RS32570"
     CDS             5001..6368
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="CCZ36_RS32570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YcaO-like family protein"
                     /protein_id="WP_128819839.1"
                     /sec_met_domain="YcaO (E-value: 4.9e-45, bitscore: 153.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSALPLEALVDPVSGVVRAVAPVEHPAGAPPRYTAMTADVADAR
                     RLGAWPADRVSLGTTFGDPRGAWIAAVAEAVERYCGNRLPPPGHPQEPRRATAAELTAE
                     GARLYGPGALPTYAPWQYGRPRFPYGELTPDTPALWTRAVENGEPCWAPVALTHLNWRQ
                     GELRSLPRTHHLNYAGIATGQGLDDAVERGLLEVVERDALELWWHLDGPTRGIDPASVP
                     GLTDDLADCGLDVHIVEMPSEFAPCVAALVHDPGRGMYAAGFACRYDPAEAARKAVLEA
                     VHTWVFTQGTVDADGWVYRAIEAGMLARGLYLDHRADRRYLDDCGPEFAAVRDLGAHVQ
                     VWLDARMTPLARRFTEPALGVVPVAAIAPGSRSALDTALAAGGHRVVTADLTTEDVAET
                     ALRVARVLVSGLIPNAPAAFGYFGCPRFAEAALARGWRTQRPTGPGDFTLAPPPHM"
     gene            6368..7902
                     /locus_tag="CCZ36_RS32575"
                     /pseudo=""
     CDS             6368..7902
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006129282.1"
                     /locus_tag="CCZ36_RS32575"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="nitroreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEHASMPHTRDRTAAPVRGADAALPAAPDLLRTSLADARSPRVPK
                     LSPYAPERPFPWSGPTTDTAGPTATNVDGPTATNAGERGTAIDLGRVLRLSLAAPLGPG
                     AGSAPFPRRAPCTRCAPTCCSGRGVRCRPGVTPTTRAPTAPTGAARPPTACPRAPSSSS
                     PWPRPAPSPTTVTGPGRYCSSTRAMPPPPSRWPGPRPPVCWSPSTRTAPCCPPPPDCPR
                     PRTGSAPGPAPSRNYPSRQSG"
     gene            7899..9638
                     /locus_tag="CCZ36_RS32580"
     CDS             7899..9638
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955801.1"
                     /locus_tag="CCZ36_RS32580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_128819189.1"
                     /transl_table=11
                     /translation="MMLHPELLRAARTARRPLGLATALLAAVAATHLAQAVLLALVLSR
                     IAQGETGALAPLLAAVIAVVLVRAALGRAQRLTAVTAGASVRVRLRDTLLERLGALGPT
                     EVTGARAGAVRATLVDGVEGVDAYLSRYLPQLLITAAVPPLLLVAVALVEPHAALALGP
                     TLLLALFGPRAWDRLLARRGKEHWDTYEALAADYLEALQGMPTLRNAGAVGRVRERLER
                     RSGALHRSTVAKLRVSLVDTGLTDLAVQGGTVAAVLVACSSAATGRTAATGTYLLLLLA
                     SECFRPVRDLSREWHAGYLGVSAADGIAALRTAEAAVPDRGTVTAAWGSAPDIRFEDVR
                     FTHPGGARPALDGVSFTAPAGRTTAVVGPSGAGKSTVLSLLLRQRDPDGGRVTVAGTDT
                     AAYTLASLRRGIAVVSQETYLFHATIAENLRIARPAATDEELRTAARTAGIDEEIARLP
                     DGYATLVGERGATLSGGQRQRLALARALIADAPVLILDEATSAVDERNQARIVRALAAA
                     GRGRTCVVVAHRLDAVRHADHIVVLDAGRVAAAGDHTTLLAGGGVYASLVAAGHTAQEE
                     RAA"
     misc_feature    10088..10104
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.9"
                     /tool="antismash"
     misc_feature    10089..10102
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.66"
                     /tool="antismash"
ORIGIN
        1 ccagccggcc cggctcgccc tcgcaccggt cgagacgccc gtcggcgcct ggaccgccct
       61 cgtcggcgtg ccggtcgggg tcgtgctact gaaacggggg cggcggcccg cccgggaccg
      121 ggggcctgcc accctcgccg ctccggtgac ttcgccggac gccctcgctc ccgtcctgcg
      181 gaaggcggaa cgatgacctt cgtcgacacc gcgcccggac cggtccgccg gaccctgcgc
      241 gcgccgggcg tccgtctggg cggcctggcg ctgctcgtcg cagtcgtcgc ctgcgccgga
      301 ctcttcgccg gtcggggcgt cacccccgac agcgtgcggg ccgtgctgct cggggccggc
      361 ggcgacccca cctccgagca catcgtgctc caactccgct tgccccgcgt gctggtggct
      421 ctggtcgcgg gggcctgcct cggggttgcc ggactcgtgc tccagtcggc cctgcgcaac
      481 ccgctggccg ggcccgaggt caccggtgtc acccccggcg cggtgctcgg tgcggtgacc
      541 gcgaccggcc tcggtctcgc ggggtgggag tccccggcgg ccgtggtcgt ggcggcctgc
      601 gtcggcggct tcgccggggc gggactgctg tggctgctca ccgggcggga ccggggcgac
      661 ccggaacaga ccgccgtcta cggagtcctt gtgtcggccg tgctcgccgg actcaccgcg
      721 gtcgtcctcc tggtggctcc cggtgaactc ggcagcgtcg tccagtggtt gatcggctcc
      781 accgagggcc gggtctggca gcactggaat ctgctctggc cgtgggccgc cttctggggt
      841 gcggcggcct ggctgctcgc cgggccgctg accctgctgc gctgcggtga cgaacaggcc
      901 gccgccgcgg gcctggccac cggccggggc aggggggcgg cgctcgtgtg cgcggtggcg
      961 ctgacggccg gcgcggtgtc ggcggtgggc gccctcgggt tcgtcgggct gctggtgccc
     1021 catctggcac tggccgtctt cggcgccgat ctgcgcgtca cgctcccggg cgccgcgctg
     1081 ctcggcgcgg cggtggtgtg cggggcggac gccgtggccc aactgctgtc ccggctgctg
     1141 gccaccgcgc tcgacgcgga ccggctgacc ctcccggtcg gcgccctgac cacctgtgtg
     1201 ggggcggggc tgctgctggt cgtggcacgc cgacgggcgg acgagagatg agggagagaa
     1261 cgagggagag gacagtggag atgagcgcga cggagagcgc gaccccgaaa gccccggacg
     1321 tcgtccgggc ggagggactg gcgttcggct accccggacg cccggtgctg cgcggggtgg
     1381 acctgagtat ccgggccggt gaactggtcg ccctgatcgg gctgaacggc tgcggcaaga
     1441 gcaccttcct caagctcgcc gccgggctgc ttgccccgag tggcgggcgt gtgctgctcg
     1501 gcggcgacga cgtggcacgg ctgccccgcc gcaccgccgc ccggcgtgcg gcactgctgc
     1561 accaatcggc accgtccgta ccggggttga cggtacgtca actcgtgcgt caggggcgtt
     1621 atgccgcgcg ggggccgctc gggatgctgc gggagggcga tgacgaggtg atgtcccggg
     1681 cgctcgcgga cgtcggtgtc acggcctggg ccgaccggcc cgtggacgcg ctgtccggag
     1741 gtgaacgcca gcgtgtccgg ctggccatgg cgctggctca ggacgccccc gtgctgttcc
     1801 tcgatgagcc gaccacctat ctggatctac ggcaccagct ggaggtgctc cagacggtcg
     1861 tacggctgcg cagggagcgc cggctgacgg tggtgatggt gctgcacgac ctcaaccacg
     1921 ccgcccggtt cgccgatcgg atcgtcgcgc tccgggaagg ccgcatcgcc gccgacgggc
     1981 ccccgggcga ggtggtgacc cggcatctgc tggccgaagt cctgggcgtg gaaggccggg
     2041 tggggatcga cgacgagggc ggctggcccg tctgttaccc agatcaccct ctcgaaccgc
     2101 tccagctatt gcggaatgaa aatcatattc attaatgtct gtgctgcggc tcgcaccaac
     2161 gccgcgaccc acacccatcc gatatgaatg gaggcttcaa ctcatggagc agaacaaggt
     2221 gttcagcccg atcgccgacc agggccagct cgcccacctc tccgccacgc actcgaacgc
     2281 cctcgtcgag aaccccttcg acgacgccgt cgaggccgac accgcggccg agaagtaagc
     2341 gacgcctgcc gctgaaggca ggtctcccgc atggcgcggg gcgggcccgc ccggtgacaa
     2401 cccgggcggg cccgccccgt tcggcccgat caccccgtcc cgccgtccct ctctccgacc
     2461 cggaggattc cgtgacccgc agtcgactcg ctcccggtgc cgggatcgtc accgttcccg
     2521 gcgccgcccc cgtgctccgg acctccggag gagagttcct gcgcatcgac accggagacg
     2581 tcaccgggga agccctggtg cgccgactgg cgggcgagga gacgccggac ggggagacgc
     2641 ccggcaagga gacgccgggc gaagagtcgc agaccgccgg actcgcccgg ctcgtcgagg
     2701 cgttcgaggc cggtgggcac gccgtgtcca ccccgccccg ggccccgctc gccggccgca
     2761 ccgtccatgt cgtcggcgac cccgtgctca ccgggcccat ggcgcgctgc gccggggcgg
     2821 aaggggccga ggtgcacagc atcaccccgg accgggtggc ggaactcgcg cggacgaccc
     2881 gggacccccg caccgaaggc cgcgtcgccg tggtgtggtg cctggactcg cccgtccccg
     2941 aagggctctg ggacgcggcg gaccggctgc cggatcgacg tatcgcctgg ctgcgctgcc
     3001 accgcgaggg ctcccacagc tggaccgagc cccttgccgc ggccccggga gacgtgacct
     3061 cccggcatgt ccgactccgc aggctcgcgg ccacccccgc ccatcgcgaa ctcgccgcgt
     3121 actgggccgg gcaccgcacc cccgacaccg gaccgcaccc caccgaggca tccgccgccc
     3181 tgatcgccgc gctgctcacc gccgatctga tcgcctggac cgaagccgaa gccgaagccg
     3241 aagcaacggg cgggcgcgcg ggcggttcgg gtcggcagcc ggccggtgtc ccggcccggc
     3301 gccggctgcg ccgggttgat ctgcgcgatc tcaccttcac cgaacacgcc gtcctccccg
     3361 tcccggacgt cgcgccactg cccgcgccga caccggcggg gacgcgcgca cggtccggcg
     3421 ccgccgaggc ccgcccgtga acacccgtac cgtgtccgtc ctcacgccgg acggcacccc
     3481 gctcgccacc gacgtatgcc tcccggacgg gggccgcccc cgccccgccg tcctgatccg
     3541 caccccgtac gggcgcgatg cccaccgtgc cgagctgcgt ggctgggcgg cacacggatt
     3601 cgccgccctc gcccaggacg tacgcggccg ccacggctca ccgggggagt ggcacccgta
     3661 cggggaccac gagaaggcgg acggagcggc cacggtcgcc tgggtgcgcg cacaggcgtg
     3721 gagcaacgga gaggtcgtcg ccgtcggcgc ctcctacgcg gcgtactgcg ccctcgtcac
     3781 cgcactcgac ggccccgacg gcccccggga cgccgttgcc gaaaagggct ttgcgacgga
     3841 gtccccgacg ccgtcatcgc cgccgttccc gcgctcgggc tcaccgagac cgcgcgcgag
     3901 cacggggggc cggagcggct gtgggcccgg gccggctggt gggcggccca cggcgaccgg
     3961 cacgactccg acccggacgc gctggggcgc gcgctggccg acgccccccg gctgctcgaa
     4021 cacctcccgg tcgccggcct gggggagcgg ctggccgcgg gtctcgggcg tgaactgcct
     4081 tcctggcccc ggctctgggc cgaccgggag cgcggccgcc tcgtggcgct cggctccgcg
     4141 gcccgccttc cgctgctcgc cgtcggtggc actcgcgacc ccttcgccga ggacaccgtg
     4201 gccctctggc gcggctgggg cggaccggcg cgtctgctgc tcggcccctg ggggcaccgc
     4261 ctcaccgccg accggtccgc gcccgcccgc gcgcgtgtca acctcggcgc cctgtacgta
     4321 cgatgggccc gcgccgcgct cgtcgggcga ctggatccgg cccgccacgg ggtcatcgcc
     4381 ctcggcgaca gcggccgttg gcacagcatc caccgggcgg tgtcctcctc cgaagccgag
     4441 tgccgttggc ccttcgcgtc gtccaccggt ctacggctgc tccacggagc cgagttcaac
     4501 gccgacccgg agcgccccgt gcgctccgac gacctcgccg tcccggtcga cggcggcccg
     4561 gccgaccgct gtctgctgct ctcgccgccg ctgccccgcc ccctcgacct ggcgggggcc
     4621 gccgtagccc ggatcaacgc caccgccgac acaccgtcgg ccgactgggc cgtgcgcctg
     4681 accgcgctcg acccgtccgg ccgggccgat ccgctcgcct tcggcatcgt ccggcgcgcc
     4741 gccccgcccg gcgaagccgc ggacatcacc gtgccgctcg gcaccctggg ccgcaggctg
     4801 cccgccggta cccggttgcg ggccgagatc gccggacacc acttccccgc ccacgcccgc
     4861 aacccgcaca ccggcgacga cccggtcacg gccacccgcc tcaccccgtc ccgccgcacc
     4921 gtgaaccccc ggggcagcgc cctccacctg cccgtcgtcg cccggcgcca ctacgtcgag
     4981 cccgtaccgg agatatgccg ttgaccagcg ccctgcccct cgaagccctc gtcgaccccg
     5041 tcagcggggt cgtccgcgcc gtcgcacccg tcgaacaccc cgccggtgcg ccgccccgct
     5101 acaccgcgat gaccgccgac gtcgccgacg cccgccgcct cggcgcctgg cccgccgacc
     5161 gggtctcgct cggcaccacg ttcggcgacc cccggggcgc ctggatcgcc gcggtggccg
     5221 aggccgtgga gcgctactgc ggcaaccgcc tcccgccgcc cggccacccc caggagcccc
     5281 ggcgggccac cgcggccgag ctgaccgccg agggcgcccg cctctacggc cccggcgctc
     5341 tgccgacgta cgcaccgtgg cagtacggcc gccctcgctt cccgtacggc gaactcaccc
     5401 ccgacacacc ggcactgtgg acccgggcgg tcgagaacgg ggaaccctgc tgggcccccg
     5461 tcgcgctcac ccacctcaac tggcgtcagg gggagctgcg ttcactgccc cgcacccacc
     5521 acctcaacta cgccggcatc gccaccgggc agggcctcga cgacgccgtc gagcgcgggc
     5581 tcctcgaagt cgtcgagcgc gacgcgctgg agctgtggtg gcacctggac gggcccaccc
     5641 gcggcatcga cccggcgagc gtacccgggc tcaccgacga cctggccgac tgcgggctgg
     5701 acgtgcacat cgtggagatg ccctccgagt tcgccccctg cgtcgcggcc ctcgtgcacg
     5761 accccgggcg cggtatgtac gcggcggggt tcgcctgccg gtacgacccg gcggaggccg
     5821 cccgcaaggc cgtcctggag gccgtgcaca cctgggtgtt cacccaaggc acggtggacg
     5881 ccgacgggtg ggtgtaccgg gcgatcgagg ccgggatgct cgcccgcggc ctctacctcg
     5941 accaccgggc cgaccggcgc tacctcgatg actgcgggcc cgagttcgcc gccgtccgcg
     6001 acctcggcgc ccatgtccag gtgtggctgg acgcccggat gaccccgctc gcccgccgct
     6061 tcaccgaacc cgccctgggc gtcgtcccgg tcgccgcgat cgctcccggc agccgcagtg
     6121 cgctggacac ggcgctcgcc gccgggggcc accgggtcgt caccgcggac ctcaccacgg
     6181 aggacgtcgc cgagaccgcg ctgcgcgtcg cccgggtcct ggtctccggg ctcatcccca
     6241 acgccccggc ggccttcggc tacttcggct gcccgcgctt cgcggaagcg gcgctcgccc
     6301 ggggctggcg cacccaacgc ccgaccggtc cgggcgactt cactctcgcc ccgcccccgc
     6361 acatgtgatg gagcacgcca gcatgcccca cacgcgggac cgtaccgccg cgcccgtccg
     6421 cggggcggac gccgccctgc ccgccgcacc ggacctcctg cgcacgtcgc tcgcggacgc
     6481 ccggtcgccg cgtgttccaa agctctcccc gtacgctccg gaacgcccgt tcccgtggag
     6541 cggccccacg accgacaccg ccggccccac ggccacgaac gtcgacggcc ccacggccac
     6601 gaacgccggc gagcgcggga ccgcgatcga cctgggccgg gtgctacggc tctccctggc
     6661 cgcgcccctc ggcccagggg ccggctccgc cccgttccct cggcgggcgc cctgcacccg
     6721 gtgcgcgccc acctgctgct cgggccgggg tgttcgctgc cgcccgggcg ttacacctac
     6781 gacccgcgca cccaccgcgc ccaccggcgc ggcccggccg ccgaccgcgt gcccccgggc
     6841 gccctcgtcg tcctcaccgt ggccgcgtcc cgcaccgtcg cccactacgg tcaccgggcc
     6901 tggccgctac tgctcctcga cgcgggccat gccgccgcct ccctcgcgct ggccggggcc
     6961 acgaccgccg gtgtgctggt ctccctcgac gcggacggct ccctgctgtc cgccgccgcc
     7021 ggactgcccg aggccccgga ctggcagcgc acctggcccg gcaccgagcc ggaactaccc
     7081 ctcgcggcag tccggttgac cccccggggc ggcccctgtg agaccgagcc gccgctgggc
     7141 gcctgggccg cgctgccccg cgcctcggcc ccgactccgc aaccaggagc cgacaccacg
     7201 ccaccccgtg aactcgctgc ggcacggcac ctgttgcacc acatcgccga agcgcccggg
     7261 cggcccggcg gcacctggca cccggcgtcg cgccccggag aggtgaccga cgaagctctg
     7321 gagacgcgcc ggagcgcccc gcccgacgac ctgaagcgcc cacccgcctc cgagccgctc
     7381 gcccagatcc tggccacggc ccggagcgtg cggccgggcg ggccctcctg gaccgtggcc
     7441 gtgggcgggg ccgaaccggc cctgtacgcg gcggctcccg gcggaccggg cctcgacgtc
     7501 cgcgccgtgg gcgacgcgcg ccccactctc gcccactggg ccgcgggcca gcagtggatc
     7561 gcgacgtcgg gcgcggtgct cctggcccac ggctgccccg caaacgcatc gcgcgccacc
     7621 gtccgcggca gccacctcgt cgccggatac gcggccggca cggcccaggc gcacgccgcc
     7681 gcactgggtc tgcgctcacg ccccatcggc tcctggcaac aggccgacct gggcgccgcc
     7741 ctcggcgaca cccccggacg cgactggatc gtgcacggtc tcgcgctcgg cgcacccccg
     7801 acgacaccgg ccaccccagc cacgtcggcc cccacgcccg ccaccccacc cacggcatcc
     7861 gccgccccgg cagccccgtc cggcgaggaa gaacgcccat gatgctccac cccgaactcc
     7921 tgcgcgccgc gcgcaccgca cgccgcccgc tcggcctcgc caccgcactc ctcgcggcgg
     7981 tcgccgccac ccacctcgcc caggccgtcc tcctcgccct cgtgctctcc cggatcgccc
     8041 agggggagac aggcgccctc gccccactgc tcgcggccgt gatcgccgtc gtcctggtcc
     8101 gcgccgcgct cggccgggcc cagcgcctga ccgcggtcac cgccggcgcc tccgtacggg
     8161 tgaggctgcg cgacaccctg ctggagcggc tcggggcgct cggccccacc gaggtcaccg
     8221 gtgcgcgggc cggcgccgta cgggccacgc tggtggacgg ggtcgagggc gtcgacgcgt
     8281 acctctcgcg ctatctgccc caactcctca tcaccgccgc cgtgccgccg ctgctgctcg
     8341 tcgccgtcgc tcttgtcgag cctcacgcgg cgctcgccct cgggcccacc ctgctgctcg
     8401 ccctcttcgg gccgcgtgcg tgggaccgac tgctggcgcg gcggggcaag gagcactggg
     8461 acacctacga agccctcgcc gccgactacc tggaagccct ccagggcatg ccgacgctgc
     8521 gcaacgccgg tgccgtgggc cgcgtacggg aacggctgga gcggcggtcg ggcgccctgc
     8581 accgaagcac cgtcgccaaa ctgcgggtct cgctcgtcga caccggcctc accgacctgg
     8641 ccgtccaggg cggcacggtc gccgccgttc tcgtggcgtg ctcctcggcc gccaccggcc
     8701 gcaccgccgc caccggcacc tacctcctgc tgctgctcgc ctccgaatgc ttccgccccg
     8761 tccgcgacct ctcccgcgag tggcacgccg gctacctcgg ggtgtcggcg gccgacggaa
     8821 tcgcggccct gcgcaccgcc gaggccgccg tcccggaccg gggcaccgtg accgcggcct
     8881 gggggagtgc gcccgacatc cgtttcgaag acgtgcgctt cacgcacccg gggggcgccc
     8941 ggcccgccct cgacggcgtg tccttcaccg cccccgccgg gcgcaccacc gccgtcgtcg
     9001 gcccgtccgg cgcgggcaag tcgaccgtgc tgagcctcct gctgcggcaa cgggacccgg
     9061 acggcgggcg cgtcaccgta gccggcacgg acaccgccgc gtacaccctc gcctcgctcc
     9121 gccggggcat cgccgtggtg tcgcaggaga cctacctctt ccacgccacg atcgcggaga
     9181 acctccgcat cgcccgcccc gccgccacgg acgaagaact gcgcaccgcc gcccgtaccg
     9241 ccgggatcga cgaggagatc gcccgacttc cggacggtta cgccaccctc gtcggcgaac
     9301 gcggcgccac gctctccggc ggacagcgcc aacggcttgc cctggcacgg gcgttgattg
     9361 ccgacgcccc cgtcctgatc ctggacgagg ccaccagcgc cgtcgacgaa cgcaaccagg
     9421 cccggatcgt ccgggcactg gcggcggccg gccgcggccg cacctgcgtc gtcgtcgccc
     9481 accggctcga cgccgtccgc cacgccgacc acatcgtcgt cctggacgcg ggccgtgtgg
     9541 ccgcggcggg cgaccacacc accctgctcg cgggcggcgg cgtctacgcc tcgctcgtcg
     9601 cggccggaca caccgcacag gaagagcgcg ccgcatgacc ccgatcccgc gcacgaccca
     9661 ggacccgccc cagccccctg ccccgcccac gacccaggtc ccggacccgg ctccgaccgg
     9721 tgccctgcgc tcgctcctcc cggtcctcgg cgcgcaccgc gccaccgtgc tccgcacctg
     9781 cctggccgcc ctcgtcgacc aggccgccct ggtggccctg gtcaccctcg ccgcgtacac
     9841 ggtgggcacc gctgtcatcg agcaccgccc gcccgccccc gggaccgtcg ccgtcctgat
     9901 cgggctcgtc ctcctccggg cgctggccac ctggcgcgag atggacctct cgcacgacct
     9961 cgcctaccgg gtcctggccg aactgcgcgt ccgggtcttc gacggactgg cccgcagcgc
    10021 ccccgcccgg atcgcgggca ggcgcagcgg cgacctcgcg gccaccgcgc tcggggacgt
    10081 cgaggcgctg gaattcttct acgcccacgc catcgcccaa ctcctcgcct ccggtgtggt
    10141 cttcgcggtg tcggcggccg tgctggcgac cctcgggccc tggctgctgc tcgccgtcgt
    10201 acccgccgcg ctgctcctcc tctggtcgcc gctgatcgag gcgcgcggtc gggccgaacg
    10261 cggacatcgc acccggagcg cgctcgccga gctgtcgtcg gagaccgtgg agagcgtcga
    10321 cggactccgc gagctcctga tgacggggtc gctcaaccgc aggcgggcgc ggctccgggc
    10381 cgccgggcgg cggctggccc gcgcccagcg tgccgaacag tcgtgggaga ccggtgcggg
    10441 cgctgcccgc gacctgctgg tcgtcgccgc cgtcatcggg gtcgtggcgg ccgccgccga
    10501 cgccgcgtcc gccggacggc tcgacggggc gtgggccccg gccgccatgg cactggccct
    10561 gggcgcactg gccccggtcg ccgagtcggc ggccgcgctc ggccgggcgg gtggcctgcg
    10621 cgccgccgcg gcccgggtcc gggccgccgt gcacgccccg gccggcgccc ccgccgccac
    10681 cgctccccgc cccgtcccgc cgggcccgct cggcctgcgg ctgcgcggcg tacggttcgg
    10741 ctacggggga ggggccgtgc tggacggcgt cgacctcacc gtccgcccgg gggagaccgt
    10801 ggccctcgtc ggagcgtccg gggccggcaa gtcgacctgc gcccacctgc tggcccgcta
    10861 ctgggacccc gccgagggcg ccgtggaact cgtgcccctc gcccccgccc accccgtgga
    10921 cctgcgggac ctcgccgagg acgacctgcg cgccgccgtg tccgtggtcg ggcaggaggc
    10981 cccgctcttc cacggcaccc tcgccgagaa cctccgcctg ggcgcccccg acgcgacggc
    11041 ggacgaggtg gacgcggtgg cccggatctg cggcgtcgac accgtcgccg ccaccctgcc
    11101 cgacggactc gacaccgcgg tcggtgagcg cggcgcgacc ctctccggcg gccaacgcgc
    11161 ccgggtggcc ctggcccggg ggctgctgag cggcccgcgc gtcctcgtcc tggacgagac
    11221 gaccgcccac ctggaccacc gtggtgacgc ggaactggcc cgggcgctcg ctgccgactc
    11281 cgccacccgg gcgaccctgg tgatcgccca tcgcccggcc accgtccgca gggccgaccg
    11341 gatcgcggtc ctggacggcg ggcgcatc
//
