LOCUS       NZ_CP021707            12931 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces sp. S063 chromosome, complete genome.
ACCESSION   NZ_CP021707
VERSION     NZ_CP021707.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S063
  ORGANISM  Streptomyces sp. S063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Complete genome sequence of Streptomyces sp. S063, a producer of
            anti-complement compounds and various secondary metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAY-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:19:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,905
            CDSs (total)                      :: 6,817
            Genes (coding)                    :: 6,244
            CDSs (with protein)               :: 6,244
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 574
            CDSs (without protein)            :: 573
            Pseudo Genes (ambiguous residues) :: 0 of 574
            Pseudo Genes (frameshifted)       :: 432 of 574
            Pseudo Genes (incomplete)         :: 192 of 574
            Pseudo Genes (internal stop)      :: 13 of 574
            Pseudo Genes (multiple problems)  :: 61 of 574
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:16:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6114173
            Orig. end                         :: 6127104
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021707.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Xinqing Zhao, Life Science
            and Biotechnology, Shanghai Jiaotong University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..12931
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="hydrogen-cyanide"
                     /region_number="20"
                     /rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)"
                     /tool="antismash"
     cand_cluster    1..12931
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="single"
                     /product="hydrogen-cyanide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12931
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7931](+)"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7931
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
     misc_feature    43..59
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 23.98"
                     /tool="antismash"
     misc_feature    complement(859..872)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.87"
                     /tool="antismash"
     misc_feature    complement(1994..2009)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.36"
                     /tool="antismash"
     gene            complement(2084..3262)
                     /locus_tag="CCZ36_RS27955"
     CDS             complement(2084..3262)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0045227 - capsule polysaccharide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072430.1"
                     /locus_tag="CCZ36_RS27955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CapA family protein"
                     /protein_id="WP_069736869.1"
                     /transl_table=11
                     /translation="MGRAAGLLAIAVGLTVSCGSQPAQPEAKAGGRSFTVAAAGDVLIH
                     PELVEQAAKDAEKSGRGEAGLDFGPLLAGVKPVISKADLAICHMETPVGNPKGPFQGYP
                     EFLVPPQILTSLKDVGYDTCSTASNHTFDHGLKAVRRTLDAMDKVGLGHSGSARTPKEA
                     EQINIRDVNGVKVAHLSYSWESFLNPTPEKQSWAFNRSRTEDIKKDEKRARDKGAEVVL
                     LSLHWGLEHYNEPSVPQLDMAQRITEETGIDLVIGHHAHVVQPIQKVNGTWVAYSLGNQ
                     VARHSSPTGLTEEGAIGWFEFRETADGWDVSARYRTTLVDVPPEIEPGEKAPEGAVEDL
                     RLVDVQQALENPEGLPADRTARYRLAEDRTRGFLYNRGAPGGDGLKRLSLEK"
     misc_feature    3353..3368
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.09"
                     /tool="antismash"
     gene            3370..4269
                     /locus_tag="CCZ36_RS27960"
     CDS             3370..4269
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072431.1"
                     /locus_tag="CCZ36_RS27960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_128818806.1"
                     /transl_table=11
                     /translation="MGLLLALVGCQTEPSPAPEDTVPRARELVDLRSRILGYTAKFRAD
                     APYRPPGKEQRERLAKAVGSLLSGDAQGAERRLAPLGLGVTRLTDTDSGRRYDEIAATG
                     PGESARWGRLYLNADSTVRWNAQVPHPVSDRDTEDLGIRLLEQNPGGALVIAGSHRRAG
                     GNGEADVAHREDSAFHTIVVELQKRGVPGVQLHGFSDSSDRPYDAVVSTGAVEAAPAEV
                     VALADRMDDEGLRVCRAWAARCPLEGRSNVQGRSAEREHAGFVHVELARRARADGGRDT
                     EEAAEALAGLVAGWNAGG"
     gene            complement(4266..4724)
                     /locus_tag="CCZ36_RS36030"
     CDS             complement(4266..4724)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012398.4"
                     /locus_tag="CCZ36_RS36030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_237302751.1"
                     /sec_met_domain="Aldedh (E-value: 1.2e-09, bitscore: 35.9,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGARRRAATVTTGEPFDPAYRDASPEQVAEAAGCPVVVKAHPAHP
                     GTGEAMARAALAAALTGVPAGVFALLVGRGHEASLASVGDPGVAAAGFTGPGSAGPAPL
                     VAAAVPRHRARAAAQWRNGCRRRPRRGGRRSAARCRSPSGPITITATG"
     misc_feature    complement(4934..4954)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 21.93"
                     /tool="antismash"
     misc_feature    complement(4956..4966)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: strong, score: 22.4"
                     /tool="antismash"
     gene            5001..6161
                     /locus_tag="CCZ36_RS27970"
     CDS             5001..6161
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: DAO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454561.1"
                     /locus_tag="CCZ36_RS27970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_164873558.1"
                     /sec_met_domain="DAO (E-value: 2.9e-65, bitscore: 219.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /sec_met_domain="Trp_halogenase (E-value: 4e-05, bitscore:
                     21.3, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVVIVGAGIVGAACAFHAASAGLGVTVLDRGPVGAGTTSRGEGN
                     ILLSDKEPGPELELARLSRDLWGEASEELGARSVEFESKGGLVAASTPEGLAALHAFAA
                     RQAAAGVRTELVTCAREFEPHIAPGLPGAVHYPQDAQVQPVLAAAGLLQAAVRRGARVR
                     TGEAVAAVTGTGGRITGVRTADGSVLAADAVVNAAGTWGGEVGRRLGAPVEILPRRGFV
                     LVTEPLPPMIRHKVYSADYVANVASNGEGLETSCVVEGTRAGTILIGASRERVGFDTAM
                     NPDVVALLAAQACRLFPFLRDVHLIRAYRGFRPYCPDHLPVVGPDPRVPGVLHACGHEG
                     AGIGLAPGTGALITAQLLGRPWRGADPAAHTGLLPDRFLTTGGVPK"
     gene            6158..6448
                     /locus_tag="CCZ36_RS27975"
     CDS             6158..6448
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972635.1"
                     /locus_tag="CCZ36_RS27975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_069741330.1"
                     /sec_met_domain="Fer2_4 (E-value: 1.8e-22, bitscore: 77.9,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGAAAETAATDVPTVTVDGEPLAFVPGQTLAAALVASGRVAWRT
                     TRGGQRPRGVFCGIGVCYDCLVAVDGRRGQRACLVRARAGMAVATEEGDDD"
     gene            6441..7931
                     /locus_tag="CCZ36_RS27980"
     CDS             6441..7931
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Pyr_redox_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_BFD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378675.1"
                     /locus_tag="CCZ36_RS27980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_128818808.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 5.3e-20, bitscore:
                     70.5, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 6.9e-12, bitscore:
                     44.2, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEPRDLGGLPAMQKPHDLVVVGAGPAGMAAAATALDGGLRVALV
                     DAGPAPGGQFWRHPPDHARDAVPTEDLHHDLRTYRALRATLAAHERTGRLALLLDHHVW
                     TTARAADGFAVHAVDRGRPPEERAVVLRAPALLVATGAYDRQLPFPGWDLPGVLTAGGL
                     QSLLKGGGVVAGRRVVLGGTGPFLLPVAAALAARGAEVVAVCEAAAPSAWLRHPAPLLR
                     NPAKWAEAAGYAGTLARHRIPVRTRTGIIGAEGAGRVAVVRTASLGADGAPLPGTERRI
                     EADTVGVGWGFVPQLDLLLPLGCDLADAGDGTTAAAVDAGQRTTVPGLYAAGETCGVGG
                     AALALSEGRVAAVSVLTDLSAPGRPGIRPLAAERRSVARHRAFARALARAHPVPRNWPA
                     WLTDDTTVCRCEEVTAGAVRAARADGPATDHRQVKQLTRAGMGWCQGRMCGPAVHCLVA
                     ARAESYTPAERLIATPVTLGALADSSTFPTGDTPTEPT"
     gene            7941..8855
                     /locus_tag="CCZ36_RS27985"
     CDS             7941..8855
                     /EC_number="4.1.3.3"
                     /EC_number="4.2.1.41"
                     /EC_number="4.3.3.7"
                     /GO_process="GO:0009436 - glyoxylate catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0071704 - organic substance metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072436.1"
                     /locus_tag="CCZ36_RS27985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_164873559.1"
                     /transl_table=11
                     /translation="MNHVDRTAPARMPWHGVIVATSLPFDRDLAVDHGAYGDNVAWLAA
                     QGLHGVAPNGSLGEYQTLTYEERDRVVETAVAHAPEGFTVMPGVGAYGAIEARRHALFA
                     KDAGCQAVMCLPPNAYRADDRAVLEHYAMVASAGLPVTAYNNPIDTKVDLRPELLAKLY
                     AEGFIVAVKEFSGDVRRCYAISELAPGLDLIIGTDDTLLEVGVAGAKGWVAGYPQVFPR
                     ACLDLYEAALAGDLATALPLYRRLHSVLRWDSRTEFVQAIKLGQDMIGRTGGVCRPPRR
                     PLDPETEAVVRSATRALIDAGVN"
     gene            8857..9858
                     /locus_tag="CCZ36_RS27990"
     CDS             8857..9858
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378674.1"
                     /locus_tag="CCZ36_RS27990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="proline racemase family protein"
                     /protein_id="WP_128818809.1"
                     /transl_table=11
                     /translation="MLSTVCYHAVDSHTEGMPTRVITGGVGVLPGATMAERRQRFMAER
                     DGLRTLLMCEPRGHGAMSGAILQPPTRPDADFGVLFIEVSGCLPMCGHGTIGVATVLVE
                     TGMVEAVEPETLIRLDTPAGLVTARVAVRDGRAESVTLENVASYSHALDQVVDVAGFGP
                     VRYDMAYGGNFYAIVRTEDLGIPFDRAEKGRLLDAGLAVMRAVNEQNPVVHPENPAIDV
                     CHHVYLEAPGSTAEHSRHAMAIHPGWFDRSPCGTGTSARMAQLHARGLLKTGQDFVNES
                     FIGSRFTGRILDESTVGGRPAVLPSVTGRAWITGTAQYLLDPNDPYPEGFTV"
     gene            complement(9937..10647)
                     /locus_tag="CCZ36_RS27995"
     CDS             complement(9937..10647)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128212.1"
                     /locus_tag="CCZ36_RS27995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_128818810.1"
                     /transl_table=11
                     /translation="MSELKSRKLISVQEHLRDQVAGALRAALIAGELQPGAIYSAPTLA
                     AEYGVSATPVREAMLDLAREGLVEAVRNKGFRVTELSERDLDEYTEIRALIEIPTIGRV
                     TRTASREQLEAVRPVAEEIVAAAQRGDLIGYLESDRRFHLDLLALAGNARLVETVADLR
                     KRSRLYGLTDLSQEGSLVGSAREHTALLDIMIEGDAEAAEEHMRRHLAHVRTLWAARKR
                     EAERAAPSRKLGAR"
     misc_feature    10674..10690
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.35"
                     /tool="antismash"
     misc_feature    10678..10688
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            complement(10730..12190)
                     /locus_tag="CCZ36_RS28000"
     CDS             complement(10730..12190)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965659.1"
                     /locus_tag="CCZ36_RS28000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_128818811.1"
                     /transl_table=11
                     /translation="MTSTPPARLHTGSHDLPVPAALDAFMATGWAPSPLPADARFPGHA
                     LLPGRRQRLSARFPGERLVIPAGTLKVRSNDTDHRFRPHSAYAWLTGLTGEEQPDHVLV
                     LDPSGPDGHEAVLHIRPRSPRDTSGFYRDRRYGEFWVGRRPDLDETAALTGLRCAHLDG
                     LPRLLAGPQPPTRLLAGVDPHVDDLLPARSHTPFGDAELDSVLAELRLLKDPWEVSQLQ
                     LAVDHTTSGFEDVARSLPDALRHPRGERWIEGVFNLRARTEGNGTGYETIAAAGAHACV
                     LHWIRNDGPLSPSQLLLLDAGVETDTLYTADITRTLPLSGRFSPAHRDVYELVLAAQEA
                     AIAVLRPGARFRDFHREAMRVIAEGLHAWGVLPVAPEEALADDSGLYRRYTLCSSGHML
                     GIDVHDCARARVETYLDGVLEEGHVLTVEPGLYLQPDDETLPPELRGMGVRIEDDLVIT
                     ADGAKLLSGALPRTADGVEEWMARLLDD"
     misc_feature    12311..12321
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
ORIGIN
        1 tcccggatga gcagcccgtt ctccagcggc ccggcgccca cccgcacatt ggcggcgcgc
       61 accaggtcgg gcagcgcgtc gttcggcagc ccctcgaagg cgcggaatcc gtcgctggcg
      121 gcgacggtcc gcgcgtccgc gttcacgatc cggacctcgc cgaggccggg ccgcttcagc
      181 agcgagttga ggaactccac ccgcacctcg ccgaccaggg tcatgccctt gcgctccggc
      241 acgggcgccc cggcctggac gacgggcctc ttctcgccct ggccggagac gcggaccagc
      301 gacgggtcct tctccgcgct ccacgggtgg gtgtcgccgc cggcccgggc gacgatgtcg
      361 ccgttcgcgc cgacgacgta cagcgcctgg tagcgggtgt gctcgcgcag ggcgttcttc
      421 agcacggtct cggtgccggc ggggtcgtcg acgtcgagca ggcgggaggt ggagacgagg
      481 tcggcctggg cctcgttcag cgcccggcgg gcccggtcgg cgaccaggtc ggtgcggtcg
      541 cgctggtcgt tgaccatgac ggcggggatg ctgacggtcc cgtccgtgcg gttgagcagg
      601 aggcctacgg gaacgcacca cagcagcagg aggaccgccg tcagcgccaa cggtccgcgc
      661 gcgccgcccc ggaaccggcc gggcgggcgg gcgcccacgg ggccgtcgga ggcctgagca
      721 ccgccgagct ggccgcggat acgttccagc gcggcgccga tccgggcggc ctcgccccag
      781 cggggcacgg tgaccgggcg gatcaggtcg ccgcgggcga gccggcggga ctccaggaac
      841 agtccgagca gcgggcgctg cacggtcatc cacagcacgg cgaccgcgag caggccgagc
      901 agcaccaggg cgcccgccgc gagcagcccg aagagctgcc ggctgtcgtc ggtgaaggtc
      961 tgctgctgga ccaccgggag cagggagacg accgtgaggc cgagaccggc ggcgacgctc
     1021 tccccgtcct ccgggtcgga ggcggcgagg gaggcgtacc ccacggtggc gacccggccg
     1081 ttgtagcccc cgcccaccag ggttccgctg accccggggt agccgcggga accgggctcc
     1141 cgggcgctga ccgggttctg ctcggtctcc tcggcggcct ggtcggacag ccgggtcatc
     1201 tgcttctgga ggaaggtgag ttccttgcgc tccgcgtccg agttcagcgc ctcggactgc
     1261 tcgaagccgg cggtcgcgag gatctcgcca ccgcgcgcga cgacggccat gctgcggaac
     1321 gggcccaggt tgatgggcgg cacggagagg ctgttggagg cgaccagcaa ctgctgcgcc
     1381 ccctgcttcc cctccagcac ggccatcgtc atcaggcgta cgtcgccggt ctccagccgc
     1441 accatccgcg gggtgagcgc cttgtcaccg gtgaggacgt ccttgtccac ccaggcgagc
     1501 gggatgcgct ccccgcgggc ggcgagcacc ttgccgtccg ccaggtccag caccgtggtg
     1561 ccggtccact tctggtacgc cttgctcagg tccgacagca cgcgctcggg gtcggccggc
     1621 ttgcccgtgt tcagggcggc cgcggtgcgt tcgaggtccg tgacccgctc gtcgatcgag
     1681 gcgcgcaggg cgatggcgcc gtcctcggcg aagtactgct gggaggagag caccgccttc
     1741 ggcacgaccg gttccgagcc cggccccagc accttggccg tgagccccgc gagggcgagg
     1801 atcagcacgc acagcaacgc gatcggcggc cggatgccac ccagcagcgg catgtccgca
     1861 cgtctgcggc tgcgccgccg gcctttcggc acgaggggcg cggcaggagt cgatgtcacc
     1921 ggtttcttcc ttggtcgctg cgtgtgctca gtgcccggag gaagcaccgc tgtcgcgtgg
     1981 ctgcgagacg ctgtcgtaga gaagttcgag acgctgtcat aggaaagacg gacaagcgcc
     2041 taagaggttg tactcatcgg catatgagcg ggtgtgtgcc tggtcacttc tccagggaca
     2101 gccgcttcag gccgtcaccg cccggagctc cccggttgta gaggaagccg cgcgtgcggt
     2161 cctcggccag gcggtagcgc gcggtccggt cggcgggcag cccttcgggg ttctccagtg
     2221 cctgctgtac gtccaccagc cggaggtcct cgacggcgcc ctcgggggcc ttctccccgg
     2281 gttcgatctc cggcggaacg tcgacgagcg tggtgcggta gcgggccgag acgtcccagc
     2341 cgtcggcggt ctcgcggaac tcgaaccagc cgatggcccc ctcctcggtg aggccggtcg
     2401 gcgaggagtg ccgggccacc tggttgccga ggctgtaggc gacccaggtg ccgttgacct
     2461 tctggatcgg ctgcaccacg tgggcgtggt gcccgatcac caggtcgata ccggtctcct
     2521 cggtgatccg ctgggccatg tccagctgcg ggacgctcgg ctcgttgtag tgctccaggc
     2581 cccagtgcag ggagagcagt accacctcgg cgcccttgtc gcgggcccgc ttctcgtcct
     2641 tcttgatgtc ctcggtacgg gaacggttga aggcccagct ctgcttctcg ggcgtggggt
     2701 tgaggaagga ctcccaggag tacgagaggt gagcgacctt gacgccgttg acgtcccgga
     2761 tgttgatctg ctctgcttcc ttcggcgtcc gcgccgaccc gctgtgcccg aggcccacct
     2821 tgtccatggc gtccagcgtg cggcgcacgg ctttcagtcc atggtcgaag gtgtgattgg
     2881 aggctgtcga gcaggtgtcg tatccgacgt ctttcaggct ggtcaggatc tgcggcggaa
     2941 ccaggaattc cggatatccc tggaacggcc ccttggggtt cccgacaggt gtctccatgt
     3001 gacagatcgc gaggtcggcc ttgctgatca ctggcttcac cccggcgagc agcggcccga
     3061 aatccaggcc ggcctccccg cgtccgctct tctccgcatc cttggcggcc tgctcgacca
     3121 gctcgggatg gatgaggacg tctccggccg cggcgacggt gaaactgcgg ccgccggcct
     3181 tggcctcggg ttgcgccggc tgcgagccgc acgacacggt caggccgacg gctatcgcca
     3241 gcaggcccgc cgcccgaccc ataccgagag aattacggaa tgtcactgag tcatacttac
     3301 atgcgcctcg tgtgtgatcg tcgtattgcc atcacgggac gatcacgttt cctccgcatt
     3361 tttgtcccgg tgggtttgct cctggctctg gtcggttgcc agaccgaacc gtccccggcc
     3421 ccggaagaca ccgttccgcg cgcccgggaa ctggtcgacc tgcgcagccg cattctcgga
     3481 tacaccgcga agttccgcgc cgacgccccc taccgcccgc ccggcaagga gcagcgggag
     3541 cggctggcga aggccgtcgg gagtctgctg tcgggtgacg cccagggcgc cgagcgccgg
     3601 ctcgccccgc tgggcctcgg tgtgacccgc ctcaccgaca ccgactcggg tcgccgctac
     3661 gacgagatcg ccgccaccgg gccgggcgag agcgcccgct ggggccgcct ttacctgaac
     3721 gccgactcca ccgtccgctg gaacgcccag gtcccgcacc ccgtctccga ccgcgacacc
     3781 gaggacctcg gtatccggct cctggagcag aaccccggcg gcgctctcgt catcgccgga
     3841 tcccaccggc gggccggcgg caacggcgag gccgatgtgg cccaccgcga ggacagcgcc
     3901 ttccacacga tcgtcgtgga gttgcagaag cgtggggtgc ccggagtcca gctgcacggc
     3961 ttcagcgact cctccgaccg cccctacgac gccgtggtct ccaccggcgc cgtcgaagcc
     4021 gcgcccgccg aggtggtcgc cctggccgac cgtatggacg acgaggggct gcgggtctgc
     4081 cgggcctggg cggcgcgctg cccgctggag ggcaggagca acgtccaggg ccgctcggcg
     4141 gagcgcgaac acgccggctt cgtccacgtc gaactggccc gccgcgcccg cgcggacggc
     4201 ggccgcgaca cggaggaggc ggccgaggcc ctggccggac tggtcgcggg gtggaatgcc
     4261 ggcggttagc ccgtcgcggt gatcgtgatc ggtccggacg gcgagcggca tcgagcagct
     4321 gaacgccgac cgcctcggcg cgggcggcgg cggcatccat tgcgccactg agcagcggcc
     4381 cgtgccctgt ggcgcggcac ggcggcggcg accaggggcg ccgggcccgc cgacccgggc
     4441 ccggtgaagc ccgccgcggc gacccccgga tccccgaccg aggcgaggct cgcctcgtgg
     4501 ccccggccca ccagtagcgc gaacaccccg gccggtacgc cggtgagcgc ggcggccagg
     4561 gcggcgcggg ccatcgcctc gccggtgccg gggtgggccg gatgcgcctt gaccaccacg
     4621 gggcacccgg ccgcctccgc gacctgttcc ggcgaggcgt cccggtacgc ggggtcgaac
     4681 ggttcgccgg tcgtgacggt tgccgcgcgc cgacgggcac ccatgccggc cgccacccgt
     4741 gccggggacc tcccggccgg ccgggggcga atgcccggtg aggggcgtga gttcggtgga
     4801 tggggggcgt ctgcggccgg gtgcgggttc tcggtcgggt ggacggtgat gtgtcgggtt
     4861 cggaggtccc cgggcatccg ggtgtcgcgg tgaaactcgt cccggcggtg gcgttgtcct
     4921 cgggtcgtcc ggatgtatag cctaagcaat ggcatgtgac attgcactag aggcggtcgt
     4981 gcggacgccg aggggtggtc atggaagtcg tcatcgtcgg cgcgggcatc gtgggcgccg
     5041 cgtgcgcgtt ccacgccgcc tccgccggtc tcggcgtcac ggtgctcgac cgggggcccg
     5101 tcggtgcggg caccaccagc cgcggcgagg ggaacatcct gctctccgac aaggagccgg
     5161 gcccggagct ggagctggcc cggctcagcc gtgacctctg gggcgaggcg agcgaggaac
     5221 tcggggcgcg gtccgtcgag ttcgagagca agggaggcct ggtcgccgcc agcacccccg
     5281 aaggcctcgc ggccctgcac gcgttcgccg cacgccaggc ggcagcgggt gtgcgcaccg
     5341 aactggtcac ttgtgcacgg gagttcgagc cgcacatcgc tcccggtctc cccggcgccg
     5401 tccactaccc gcaggacgcc caggtgcagc ccgtcctggc cgccgccgga ctgctgcaag
     5461 ccgccgtccg gcgcggcgcc cgggtccgta ccggcgaggc cgtcgccgcc gtcaccggaa
     5521 ccggcgggcg gatcaccgga gttcgcacgg ccgacggttc ggtgctggcc gccgatgccg
     5581 tggtcaacgc ggccgggacg tggggcggcg aggtcggccg ccgcctcggc gcgccggtcg
     5641 agatcctgcc gcgccggggg ttcgtcctcg tcaccgagcc gctgccgccg atgatccggc
     5701 acaaggtcta ctccgccgac tacgtcgcca acgtcgcctc caacggcgag ggcctggaga
     5761 cctcgtgcgt tgtcgagggc acccgcgcgg gcaccatcct gatcggcgcc agccgtgaac
     5821 gcgtcggctt cgacaccgcg atgaaccctg acgtggtggc cctgctcgcc gcgcaggcgt
     5881 gccgcctctt cccgtttctg cgcgacgtcc atctgatccg cgcctaccgg gggttcaggc
     5941 cgtactgccc cgaccatctg ccggtcgtcg gcccggaccc ccgggttccc ggtgtcctgc
     6001 acgcgtgcgg ccacgagggc gcgggcatcg gtctcgctcc cggcaccggc gccctcatca
     6061 ccgcccagtt gctcggccgc ccgtggcgcg gtgccgatcc ggccgcccac accggcctcc
     6121 tgcccgaccg attcctcacg accggaggtg tgccgaagtg accggagcgg ccgcggagac
     6181 cgcggcgacc gacgtaccca ccgtgaccgt ggacggcgaa cccctggcgt tcgtcccggg
     6241 gcagaccctg gccgccgcgc tcgtcgcctc gggccgggtc gcctggcgga ccacccgggg
     6301 cgggcagcgg ccccggggcg tcttctgcgg gatcggggtc tgttacgact gcctcgtcgc
     6361 cgtcgacgga cggcgcggac agcgcgcctg cctggtgcgg gcccgcgcgg gcatggccgt
     6421 cgcgacggag gagggcgacg atgactgagc cccgggacct cggcggcctc cccgcgatgc
     6481 aaaagccaca cgacctcgtg gtggtgggcg ccgggccggc cggtatggcg gccgccgcca
     6541 ccgccctgga cggcgggctg cgggtcgccc tcgtcgacgc gggccccgct cccggcggcc
     6601 agttctggcg ccaccccccg gaccacgcgc gcgacgccgt tcccaccgag gacctgcacc
     6661 acgacctgcg cacctaccgc gccctccgcg cgaccctggc cgcccacgag cgcaccggac
     6721 ggctcgccct cctgctcgac caccacgtat ggaccacggc ccgcgcggcg gacggcttcg
     6781 ccgtccacgc cgtggaccgc ggcaggccgc ccgaggagcg ggccgtcgtg ctgcgcgcac
     6841 cggccctcct ggtggcgacc ggcgcctacg accgccaact cccctttccc ggctgggacc
     6901 tgcccggcgt gctcaccgcg ggcggactcc agtcgctgct caagggcggg ggagtggtcg
     6961 ccggccgccg cgtggtcctc gggggtacgg gcccgttcct gctgcccgtc gccgccgccc
     7021 tcgccgcacg cggcgcggag gtcgtcgcgg tgtgcgaggc ggcggcgccc tcggcctggc
     7081 tgcggcaccc cgcacccctg ctgcgtaacc ccgccaagtg ggccgaagcc gctggatacg
     7141 cgggcacgct cgcccggcac cgcatcccgg tccgtacccg caccggcatc atcggcgccg
     7201 aaggggcggg gcgggtcgcc gtcgtacgca ccgcctccct gggcgccgac ggggcgccgc
     7261 tgccgggtac cgagcggcgg atcgaggccg acaccgtggg cgtcggctgg ggcttcgtcc
     7321 cccagctcga cctgctgctc ccgctcggct gcgacctcgc cgacgcgggc gacggcacca
     7381 cggccgccgc cgtcgacgcc ggacagcgca ccacggtgcc ggggctctac gcggcgggcg
     7441 agacctgcgg ggtgggcggg gcggcgctcg ccctgagcga agggcgcgtg gcggccgtct
     7501 ccgtgctcac cgacctctcc gcgccgggcc ggccgggcat ccggcccctg gccgcggagc
     7561 gccgatcggt ggcccggcac cgcgccttcg cccgcgccct ggcccgggcg caccccgtgc
     7621 cccggaactg gcccgcctgg ctgaccgacg acaccacggt ctgccggtgc gaggaggtca
     7681 ccgcgggggc ggtccgcgcc gcccgcgccg acggcccggc aaccgaccac cggcaggtca
     7741 aacaactgac cagggcgggc atggggtggt gtcagggccg gatgtgcggg cccgccgtgc
     7801 actgcctcgt cgccgcccga gccgagtcct acacccccgc cgagcgactc atcgcgaccc
     7861 ccgtcaccct cggcgcgctc gccgactcca gcacgttccc caccggcgac acccctaccg
     7921 aacccacctg aggagttccc atgaaccacg tggaccgcac agcccctgcc cggatgccct
     7981 ggcacggcgt catcgtcgcg acgagcctcc cgttcgaccg ggacctcgcc gtcgaccacg
     8041 gcgcctacgg cgacaacgtc gcctggctcg ccgcccaggg cctgcacggt gtcgccccga
     8101 acggctcgct gggcgagtac cagaccctga cgtacgagga acgcgaccgt gtcgtcgaga
     8161 ccgccgtcgc ccacgccccc gagggcttca ccgtgatgcc gggcgtcggt gcgtacggcg
     8221 cgatcgaggc gcggcggcac gccctcttcg ccaaggacgc cggctgccag gccgtcatgt
     8281 gcctgccgcc caacgcctac cgggccgacg accgcgccgt cctggagcac tacgcgatgg
     8341 tggcctccgc cgggctcccc gtcaccgcct acaacaaccc catcgacacc aaggtcgacc
     8401 tgcgtcccga actgctggcc aagctgtacg ccgaggggtt catcgtggcc gtgaaggagt
     8461 tctccggaga cgtacgacgg tgttacgcca tcagtgaact ggcccccggc ctcgacctga
     8521 tcatcggcac cgacgacacc ctcctcgaag tcggcgtcgc cggggccaag ggctgggtcg
     8581 ccggatatcc gcaggtcttc ccgcgtgcct gcctcgacct ctacgaagcc gcactggccg
     8641 gcgacctcgc caccgcgctc ccgctctacc gccggctcca ctccgtactg cgctgggaca
     8701 gcaggaccga gttcgtccag gcgatcaagc tcggccagga catgatcggc cggaccggcg
     8761 gcgtctgccg gccgccccgc cggcccctgg acccggagac cgaggccgtc gtacgttccg
     8821 cgacccgggc gctcatcgac gcgggggtga actgacgtgc tttccacggt gtgttaccac
     8881 gccgtcgact cgcacaccga gggcatgccg acccgggtga tcaccggcgg ggtgggtgtc
     8941 ctgccgggcg cgaccatggc ggagcgccgg cagcggttca tggccgaacg cgacggactg
     9001 cgcaccctgt tgatgtgcga gccgcgcggg cacggggcca tgtccggcgc gatcctccag
     9061 cccccgaccc ggccggacgc cgacttcggc gtgctgttca tcgaggtctc cggctgcctg
     9121 cccatgtgcg gccacggcac catcggcgtg gcgacggtcc tggtggagac cggcatggtc
     9181 gaggcggtcg agccggagac cctcatccgc ctcgacaccc ccgccggtct cgtcacggca
     9241 cgggtcgccg tgcgcgacgg ccgcgcggag tccgtcaccc tggagaacgt cgcctcctac
     9301 agccacgccc tggaccaggt cgtcgacgtg gcggggttcg gcccggtccg gtacgacatg
     9361 gcgtacggcg gcaacttcta cgcgatcgtc cgcaccgagg atctgggcat ccccttcgac
     9421 cgggcggaga agggccggct gctggacgcg ggcctcgccg tcatgcgggc ggtcaacgag
     9481 cagaacccgg tggtccaccc ggagaacccc gcgatcgacg tctgccacca cgtctacctg
     9541 gaggcccccg gctccaccgc cgaacactcg cggcacgcca tggcgatcca ccccggctgg
     9601 ttcgaccgct caccctgcgg gacgggaacc agcgcccgga tggcccaact gcacgcgagg
     9661 gggctgctga aaaccgggca ggacttcgtc aacgagtcct tcatcggctc ccgcttcacc
     9721 ggccggatcc tggacgagag cacggtcggc ggccgacccg ccgtcctgcc ctccgtcacc
     9781 ggtcgcgcct ggatcaccgg caccgcgcag tatctgctcg acccgaacga cccctacccg
     9841 gagggattca ccgtctgacg tccgctcggc acaccggccc cagggggccc gcgccgcgcg
     9901 aaacgccaac ccccgccgcc cggcaccgac ttcggctcag cgcgcgccga gcttgcggga
     9961 cggggccgcg cgctcggcct cccgcttccg tgccgcccac agggtccgca catgcgcgag
    10021 atggcggcgc atgtgctcct cggccgcctc cgcgtcgccc tcgatcatga tgtccaggag
    10081 cgcggtgtgc tcccgcgccg aacccaccaa cgacccttcc tgggacaggt cggtgagtcc
    10141 gtacagccgg gagcgcttgc gcaggtccgc caccgtctcg acgagacggg cgttacccgc
    10201 gagggcgagc aggtcgagat ggaagcggcg gtccgactcc aggtagccga tcaggtcgcc
    10261 ccgctgcgcg gccgccacga tctcctcggc caccgggcgc accgcctcca actgctcgcg
    10321 ggaggcggtg cgggtcaccc ggccgatggt ggggatctcg atgagcgcgc ggatctcggt
    10381 gtactcgtcc aggtcgcgct cggagagctc ggtgacccgg aagcccttgt tgcgcaccgc
    10441 ctcgaccagg ccctcgcggg ccagatccag catcgcctcg cgcacgggtg tggccgagac
    10501 gccgtactcg gcggccaggg tgggcgccga gtagatcgcg ccgggctgga gttctcccgc
    10561 tatcagcgcg gcacggaggg cgcccgccac ctggtcgcgc agatgctcct gcaccgagat
    10621 gagtttgcgg gacttcagct cactcatgcg ttccccttca gatttgtcac cgcactatac
    10681 aatgtcacgt tgcgcggtgc gcccctcctc ggtcggcagc tggcagccgt cagtcgtcca
    10741 ggaggcgggc catccactcc tcgacgccgt cggccgtacg gggcagcgct ccggagagga
    10801 gcttcgcacc atcggcggtg atcacgaggt cgtcctcgat gcgcacgccc atgccacgca
    10861 gttcgggcgg cagcgtctcg tcgtccggct ggagatagag cccgggttcg acggtgagga
    10921 catggccctc ctccagtact ccgtcgagat aggtctccac ccgggcccgg gcgcagtcgt
    10981 gcacgtcgat gccgagcatg tgcccgctgc tgcacagggt gtagcggcgg tacaggccgc
    11041 tgtcgtcggc gagcgcctcc tcgggtgcga ccggcaggac gccccaggcg tgcagcccct
    11101 cggcgatgac gcgcatggcc tcccggtgga agtcccggaa gcgggctccg ggccgcagga
    11161 cggcgatggc ggcctcctgt gcggccagca ccagttcgta gacgtcgcgg tgggccggtg
    11221 agaagcggcc cgacaggggg agggtgcggg tgatgtccgc ggtgtagagg gtgtcggtct
    11281 ccacccccgc gtcgagcagg aggagttggg acggcgagag cgggccgtca ttgcggatcc
    11341 agtgcaggac gcaggcgtgc gcacccgccg ccgcgatggt ctcgtagccc gtgccgttgc
    11401 cctcggtccg tgcgcgcagg ttgaacacgc cttcgatcca gcgttcgccg cgggggtggc
    11461 gcagggcgtc gggcagggag cgcgccacgt cctcgaagcc cgacgtggtg tggtcgacgg
    11521 ccagttggag ctggctcacc tcccacgggt ccttgagcaa gcggagttcg gcgagcacag
    11581 agtccaactc ggcgtccccg aaaggggtgt gggaccgcgc gggcagcagg tcgtcgacgt
    11641 ggggatcgac gcccgcgagc aggcgggtcg gcggctgagg accggcgagg agccttggca
    11701 gcccgtccag gtgggcgcag cgcagcccgg tcagcgccgc cgtctcgtcc aggtcgggcc
    11761 ggcggccgac ccagaactcg ccgtagcggc ggtcgcggta gaacccgctg gtgtcccggg
    11821 gggagcgggg gcggatgtgg agcaccgcct cgtggccgtc ggggcccgac gggtcgagga
    11881 ccaggacgtg gtcgggctgc tcctcaccgg tcaggccggt cagccaggcg taggcgctgt
    11941 gcgggcggaa gcggtgatcg gtgtcgttcg agcggacctt gagcgttccg gcgggtatga
    12001 ccagccgttc gcccgggaag cgcgccgaca ggcgctgccg ccggccgggg agcagggcgt
    12061 ggccggggaa ccgtgcgtcg gcgggcagcg gggagggcgc ccagccggtg gccatgaagg
    12121 cgtccagggc ggccgggacc ggcagatcgt ggctgcccgt gtgcagtcgg gccgggggcg
    12181 tggaggtcat gggtctcctt cggagggtgt gccttggggg tgccggggct gccaggggtg
    12241 ccgggacggg gagccgaagc gtccgactgc gggacacgtt tcggtaacgg ggcgacgcac
    12301 tccttggctg tgcaatttca cattactatg ttacgggtca catcgcgtgg atggatgcgt
    12361 tcccggccgc tccgcctcgc gttccgcaaa cggccgccca ccgggccgct cggccgcccg
    12421 gagcaccaga tcccgccgga cccctccttc ttcctccttt ccgccggccc gttccgctgt
    12481 cgccgtgccc cgttcccgta ccgaggagtg ccccatgtcc cgtcgcagcc gtgcgctgtc
    12541 cgtatccctg agcacctcgc tggccctggc cctggccctg ctgggcgcct gctccccgca
    12601 gggaggtgac gaccgaggcc cgggcgcgcg gcagcccggt gtggcgaccg gcaccgtcat
    12661 cggcggcaca ccgaagcggg gcggcaccct gaccgtgctg tccaaccagg acttcgccca
    12721 tctggacccg gcccgcaact gggtcatgcc gaccatggac ttcggcaccc ggctgatcta
    12781 ccgcaccctc acgaccttcc gggcagcgcc cgggaagcgg ggcagcgagg tcgtccccga
    12841 tctcgcgacc gacctcggcc gatcctccga cgggggacgc acctggacct tcaccctgaa
    12901 gcccggcctc gtctacgagg acggcacccc g
//
