LOCUS       NZ_CP021707            22746 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces sp. S063 chromosome, complete genome.
ACCESSION   NZ_CP021707
VERSION     NZ_CP021707.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S063
  ORGANISM  Streptomyces sp. S063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Complete genome sequence of Streptomyces sp. S063, a producer of
            anti-complement compounds and various secondary metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAY-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:19:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,905
            CDSs (total)                      :: 6,817
            Genes (coding)                    :: 6,244
            CDSs (with protein)               :: 6,244
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 574
            CDSs (without protein)            :: 573
            Pseudo Genes (ambiguous residues) :: 0 of 574
            Pseudo Genes (frameshifted)       :: 432 of 574
            Pseudo Genes (incomplete)         :: 192 of 574
            Pseudo Genes (internal stop)      :: 13 of 574
            Pseudo Genes (multiple problems)  :: 61 of 574
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:16:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4237270
            Orig. end                         :: 4260016
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021707.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Xinqing Zhao, Life Science
            and Biotechnology, Shanghai Jiaotong University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22746
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="14"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22746
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22746
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12746](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12746
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    685..703
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.82"
                     /tool="antismash"
     gene            703..1554
                     /gene="otsB"
                     /locus_tag="CCZ36_RS19565"
     CDS             703..1554
                     /EC_number="3.1.3.12"
                     /GO_function="GO:0004805 - trehalose-phosphatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="otsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018958814.1"
                     /locus_tag="CCZ36_RS19565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="trehalose-phosphatase"
                     /protein_id="WP_069740894.1"
                     /transl_table=11
                     /translation="MGSHPERLPNPTTPAGREGLDAVLARPDRAVVALDFDGTLADIVP
                     DPEQARAHPGTVAALAALAPKVAAIAVITGRPAGVAVRYGGFAGVPGLERLVVLGHYGA
                     ERWDAVTGTVRAPAPHPGVTAVRAELPGVLHDVGAWNGTWIEEKGQALAVHTRRAQDPQ
                     AAFESLRGPLGELAAKHGLIVEPGRLVLELRPPGMDKGVALAGFVAELDAESVIYAGDD
                     LGDLAAFAAVEKLRGEGPDGVPGLLVCSGSAEVPELAERADLSVPGPAAVVDFLAALAD
                     RL"
     gene            complement(1606..2997)
                     /locus_tag="CCZ36_RS19570"
     CDS             complement(1606..2997)
                     /EC_number="2.4.1.15"
                     /GO_function="GO:0003825 - alpha,alpha-trehalose-phosphate
                     synthase (UDP-forming) activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018101576.1"
                     /locus_tag="CCZ36_RS19570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="trehalose-6-phosphate synthase"
                     /protein_id="WP_069740895.1"
                     /transl_table=11
                     /translation="MVSEHTSSSHAQVLVASNRGPITYTLDEDGTLDSKRGGGGLVSGL
                     SAVDDKLWVCAALGDGDREAVRRGVGEPGVRMLDIDAEVHADAYNGIANSVLWFVHHLL
                     YQTPVEPVFDTEFRRQWAAYEAYNRAFAQALAEEAGPEAAVLVQDYHLALVPGMLRELR
                     PDLRIGHFSHTPWAPVDYFRLLPDDIAEQLLRGILGADRAAFLTRRWSDAFIGCCTEIL
                     GGTGRTRIGVHGLGADADFLRRRSHEADVDERMAALREQVGENRKTIVRVDRTELSKNI
                     VRGLHAYRTLLETRPEWRERVVHIAFAYPSRQDLSVYRDYTAAVQSLATEINGAYGTDG
                     WTPVVLHVKDDFARSLAAYRLADVALVNPIRDGMNLVAKEVPVVSDHGCALVLSREAGA
                     YEELGEDAIVVNPYDVTGTAEALHEALTMSVDERSGRTKRLAEAATALPPQRWFLDQLE
                     ALRQE"
     gene            complement(3124..4074)
                     /locus_tag="CCZ36_RS19575"
     CDS             complement(3124..4074)
                     /EC_number="2.4.1.266"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511020.1"
                     /locus_tag="CCZ36_RS19575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glucosyl-3-phosphoglycerate synthase"
                     /protein_id="WP_069735611.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 5.5e-10,
                     bitscore: 38.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEEVERWLTRRSWSSGDRPLNRLTDARAADPRRTSVSVVLPALN
                     EEATVGAIVATIRRELMEKIRLVDELVVIDSGSTDATAAVARAAGARVVHRDAILPRIP
                     AVPGKGEVLWRSLLVTSGEIVCFVDADLKDFSADFVSGTVGPLLTDPTVQFVKAMYDRP
                     LGGSAGQGGRVTELVARPLLNLHWPQLAGFVQPLGGEYAVRRSLLERLPFPVGYGVELG
                     LLVDALHTVGLDALGQVDVGVRVHRHQDGQALGRMAAAIYRTAQLRLSRGHLVRPVLTQ
                     FERGEEGFVPRTHAVDTEERPPMREIAEYAERHAA"
     misc_feature    4100..4120
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.9"
                     /tool="antismash"
     regulatory      4228..4355
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            4374..5668
                     /gene="thrC"
                     /locus_tag="CCZ36_RS19580"
                     /pseudo=""
     CDS             4374..5668
                     /GO_function="GO:0004795 - threonine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thrC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056010.1"
                     /locus_tag="CCZ36_RS19580"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="threonine synthase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAVQTIAGNATTAPVDLGPAAALSCRECGERFELGPLFACASCFG
                     PSKWPTTCPPAPPRNCASASRPVRTTSGAMPRCCPSPPTSRTSPT"
     misc_feature    4377..4391
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.51"
                     /tool="antismash"
     gene            5704..5982
                     /locus_tag="CCZ36_RS19585"
     CDS             5704..5982
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265553.1"
                     /locus_tag="CCZ36_RS19585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MoaD/ThiS family protein"
                     /protein_id="WP_006126483.1"
                     /transl_table=11
                     /translation="MSVKVRIPTILRTYTGGQAEVPAEGTKLSEVIESLEKDHPGIAAR
                     VLDDQGKLRRFVNVYVNDDDVRFEGGLDAATPDGAGVSIIPAVAGGC"
     gene            6428..6634
                     /locus_tag="CCZ36_RS19590"
     CDS             6428..6634
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967346.1"
                     /locus_tag="CCZ36_RS19590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cold-shock protein"
                     /protein_id="WP_003967346.1"
                     /transl_table=11
                     /translation="MAQGTVKWFNAEKGYGFIAVDGGADVFVHYSAIQMDGYRTLEEGQ
                     RVEFEISQGQKGPQADMVKLAVG"
     misc_feature    complement(6476..6489)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    6829..6844
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    complement(6832..6847)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    complement(6864..6878)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.78"
                     /tool="antismash"
     misc_feature    complement(6866..6881)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.09"
                     /tool="antismash"
     gene            7000..8622
                     /gene="groL"
                     /locus_tag="CCZ36_RS19595"
     CDS             7000..8622
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /gene="groL"
                     /gene_functions="other (smcogs) SMCOG1299: chaperonin
                     GroEL"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133870.1"
                     /locus_tag="CCZ36_RS19595"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES; misfolded
                     proteins enter the barrel where they are refolded when
                     GroES binds; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /product="chaperonin GroEL"
                     /protein_id="WP_003967345.1"
                     /transl_table=11
                     /translation="MAKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGA
                     PTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLR
                     NVAAGANPMALKRGIEKAVEAVSAALLEQAKDVETKEQIASTASISAADTEIGAKIAEA
                     MDKVGKEGVITVEESQTFGLELELTEGMRFDKGYISAYFATDMERMEASLDDPYILIVN
                     SKIGSVKDLIPLLEKVMQSGKPLLIIAEDVEGEALSTLVVNKIKGTFKSVAVKAPGFGD
                     RRKAMLADIAILTGGTVISEEVGLKLENAGLDLLGRARKVVITKDETTIVDGAGDSDQV
                     QGRVNQIRAEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVR
                     NAKAAVEEGIVAGGGVALLQASAVFEKLDLTGDEATGANAVKLALEAPLKQIAVNGGLE
                     GGVVVEKVRNLPIGHGLNAATGEYVDMIAEGILDPAKVTRSALQNAASIAALFLTTEAV
                     IADKPEKAGAAAPGGMPGGDMDF"
     gene            8786..9295
                     /locus_tag="CCZ36_RS19600"
     CDS             8786..9295
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015610344.1"
                     /locus_tag="CCZ36_RS19600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_069735453.1"
                     /transl_table=11
                     /translation="MSVRATGRTGGRGRLKGVSLVVGGAVLFAAGLFVVVAGTGLSGAL
                     GMRVETFGRIDCDDTRTEKGQTVWHCSGETPAQQRANDAERERVAHEALRAHVDGVPRS
                     AEISRSRILFADHDGRMDPETITATQVFDGGRWYAHSSMLVGYGMIPLFLGAGTAAWGG
                     YRLRAG"
     misc_feature    9530..9545
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.76"
                     /tool="antismash"
     gene            9819..9950
                     /locus_tag="CCZ36_RS19605"
     CDS             9819..9950
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071616.1"
                     /locus_tag="CCZ36_RS19605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_128818240.1"
                     /transl_table=11
                     /translation="MKPQQQQKKAYVKPSMFQQGDFSKKTAGYFVGSYKEYWSRRII"
     gene            10001..12004
                     /locus_tag="CCZ36_RS19610"
     CDS             10001..12004
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071617.1"
                     /locus_tag="CCZ36_RS19610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_128818241.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.7e-29, bitscore:
                     102.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGQLRDYFVVLPDSAAGAAAAGQLPVPGEAAGRSAAPDATGPAR
                     EVGDTLTVAHPSGRPWIVARPLVRRVSQIARGSDALVLIGPDRVPDAVLAGILEGARDR
                     TGLERRLARLPGLYHVVARLSGQSWIRGTATGLRRIYHARHPAAGTIASDRPAVLARLI
                     DAPLDDSALALRLLDFLPHPLSRRPVWRGIHETGAGHGLALPAAAPGTAAVPGPTEHRW
                     WEPPPGELPLAEGARKAGDAIAASVRAHVGGLDRISCELSGGLDSTALAFAARETGPAS
                     LSLLTVAARDRYSEDETWARRAVEAAGGTPATATRNTHSAATRGRPSAPALDHHVIPAG
                     DAPYFYADLASTAAELNDEPLPVAPGRARAELLLGRAHATGSRYHLTGYGGDEIFLGLP
                     HAYQDLFHGSPFTAWSHLGGLRHQLGWPLLPTVKALFDRSTFPRWLAGAVAAAPQPVAR
                     APLFSWGVRQSLHPWLTEHATALIAEEFRAAAEQAEPIDPRRGRHVDIDGVRMGARHFQ
                     AMEDIGMTIGLPVAAPFYDDRVLEATLAVRLPERISPWRYKPLLVEAMRGVVPDALLAR
                     TTKDHMASDEHQGLREHAPELVELWTGSRLAEHGLVDARRLLRLAAEPFSPVLVEHSIS
                     STVAGETWLRTAENAWPPPEPSLPTTPSEASL"
     aSDomain        12001..12246
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CCZ36_RS19615_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="7.40E-28"
                     /identifier="RREFam002.1"
                     /label="CCZ36_RS19615"
                     /locus_tag="CCZ36_RS19615"
                     /protein_end="82"
                     /protein_start="0"
                     /score="87.4"
                     /tool="antismash"
                     /translation="MKLRKGIAVTTTEYGGVLLDEKSGSYWQLNDTSVIVVETLAAGRA
                     PEAAVERIVAEFDVERAEAESDVAELTRRLVEARILR"
     gene            12001..12252
                     /locus_tag="CCZ36_RS19615"
     CDS             12001..12252
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126488.1"
                     /locus_tag="CCZ36_RS19615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_069735451.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.8e-25,
                     bitscore: 87.4, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5.6e-13, bitscore: 47.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLRKGIAVTTTEYGGVLLDEKSGSYWQLNDTSVIVVETLAAGRA
                     PEAAVERIVAEFDVERAEAESDVAELTRRLVEARILRP"
     gene            12249..12746
                     /locus_tag="CCZ36_RS19620"
     CDS             12249..12746
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071618.1"
                     /locus_tag="CCZ36_RS19620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_128818242.1"
                     /sec_met_domain="PF13471 (E-value: 6.9e-24, bitscore: 82.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEMTMPRRGAGAGGIRLRTAIAAAFVLARLKPGRLRRTLARCA
                     RGARPATYAETSEVLDAVTAISRRCASRYGCLPRSVAVALACRMSGVWPDWCAGVWATP
                     PFSPHAWVQAEGRTVGEQAEAADLRPLMVVTVREGVQGERGDGDVGGGGAGGPGPGSGE
                     IT"
     gene            12790..14562
                     /locus_tag="CCZ36_RS19625"
     CDS             12790..14562
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126490.1"
                     /locus_tag="CCZ36_RS19625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_237302705.1"
                     /transl_table=11
                     /translation="MPAPAAAPTPPPAPGPSPLRLLLARVRPHRGVLIRAGLLSLAGSG
                     AGLAMPLMAKHAVDTFAEGRSPVAPLVALTALVLAGACLSAYGSFLMSRTGEGVVLRAR
                     DQLVCRIMRLKVPAVDRLTPGDLQSRVTSDTTLLRTVLSSGLVESFNSVLMLLGTLALM
                     AYMDLTLLGVTLVVVVGIGAVTSLLMPRIQRAQLKAQESVGAMGAALDRVLQAFRTVKA
                     SGAEERETAVVAAAARHAHDRGVSVAKWASVTEVTMTMSIQLAFLAVLGVGGARVASGS
                     LEISSLIAFLLYLFYLIGPIGGLVEGWTGLQSGLAAVRRIDEVESLPGEPAEEPVALTK
                     ADGGPLGVTFQDVTFDYGDERAPAHQRVTFDVPAGGMVALVGPSGAGKSTVFSLLERFY
                     DHEAGTITVGGRDIRDWPLAELRGSLAYVEQDAPVLAGTLRENLLFAAPDAGESELTAA
                     VARTRLDALVERLPDGLDTAVGHRGVTLSGGERQRIAIARALLRRPRLLLLDEVTSQLD
                     AVNEQALRDVILELAERTTVLVIAHRLSTVRHADRIVVLEEGRVRTAGTHEELMAGDEL
                     YRELATTQLAAEAR"
     gene            14721..15275
                     /locus_tag="CCZ36_RS19630"
     CDS             14721..15275
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126492.1"
                     /locus_tag="CCZ36_RS19630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_128818244.1"
                     /transl_table=11
                     /translation="MTHTSSSPWKSSPELSFRRAGEGDLAELVRLRDDAARWQIERGID
                     QWKPGELGPEHFGARLRAGEVWIATAGPGGPNAGAWELWWEDEPAWGVQPPVAGYVHRL
                     MTDRRTAPPGAGRALLAEAERRIAASGRPLCRLDCLTSNTRLRRYYEQAGYVVVGEQAG
                     KNGDGGRTYGVTLLEKRVGAG"
     misc_feature    complement(15346..15361)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            15442..15942
                     /locus_tag="CCZ36_RS19635"
     CDS             15442..15942
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489040.1"
                     /locus_tag="CCZ36_RS19635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SigE family RNA polymerase sigma factor"
                     /protein_id="WP_065487879.1"
                     /transl_table=11
                     /translation="MTVEEFEEFYAQAVARLTGQLYVMTGDLQEAQDVVQEAFVKAWVR
                     RGRLERDGQPEAWIRTVAWRLAVSRWRFRRRSADAWGRGSGGAEHVAPPDPDHVVLVDA
                     LRELPAQQRRTLTLHYLCDLTVEQIAGETGLSTSTIKTHLVRGRAALAHRLRDPRIEEA
                     PDV"
     misc_feature    complement(15457..15470)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.98"
                     /tool="antismash"
     gene            16531..17754
                     /locus_tag="CCZ36_RS19645"
     CDS             16531..17754
                     /GO_function="GO:0000009 - alpha-1,6-mannosyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004376 - glycolipid mannosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006506 - GPI anchor biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071623.1"
                     /locus_tag="CCZ36_RS19645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="mannosyltransferase family protein"
                     /protein_id="WP_206515752.1"
                     /transl_table=11
                     /translation="MSTLSPGLRPSPVRPAPEPRAAELRLARFRLAPADRGILWLYLLT
                     RVSLWITAHFARWLFPAQSGVREAAPVLAPFQQWDANHYLHIARDGYFPAGAGPWTSGW
                     DNREAFFPGYPLLLRAVHTVVPHWTAAGLLISFVAGAVAVLALARVARAYLPEDAAGPR
                     TAVLFLLSPCAVFLAAGYTEALFLAFALPAWLVAMKHRWALAAVLTTSATAVRVSGLFL
                     AAAVGLLFLLSVRAGEGRRRWRAAGWTLLPALPPAAYSWYLHARTGDWMAWKHAQERGW
                     YRTFHAPWEAWANTWTGAFGGTQSTGYAFMFQAELAAMVVGLALVVLLVRRRRWPEAVY
                     VALSLWALGTSYWYTSVPRATLLWWPLWIGLAALSLRRPWFRTAYLCVAAPVTTLVALT
                     FLTGRWAG"
     gene            complement(17885..18463)
                     /locus_tag="CCZ36_RS19650"
     CDS             complement(17885..18463)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981641.1"
                     /locus_tag="CCZ36_RS19650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_069735447.1"
                     /transl_table=11
                     /translation="MSVQERKERERANRERLIVATARELADQQGWDAVTTRRLAERIEY
                     SQPVLYSHFRGKREIIGAVALEGATEMASALRAASSGADGRRTRVAALAHAYLEFAERN
                     PAVYDALFQLDGGLAFAREDTPEPLKDAFAALLETLGEVAGEGVHPALFTELFWSALHG
                     LATLTRAGRLLPEGAGERLDLLVERLAVL"
     gene            18555..19001
                     /locus_tag="CCZ36_RS19655"
     CDS             18555..19001
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482038.1"
                     /locus_tag="CCZ36_RS19655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="anthrone oxygenase family protein"
                     /protein_id="WP_069735446.1"
                     /transl_table=11
                     /translation="MLDVLEVVTTVIVGLLVGVEFSVAFVINRILDALPDDSAQRGRSH
                     GGRMLGAVMPFWYIGSLVLSAIWAVAGWGEPGAGLVVAAGALLLLGVLMSLLLLVPIND
                     RGKTWTSENRPEDWKEQMNRWDRYHYARVAVLIGAFASLVAALA"
     gene            complement(19038..19502)
                     /locus_tag="CCZ36_RS19660"
     CDS             complement(19038..19502)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126496.1"
                     /locus_tag="CCZ36_RS19660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_069735445.1"
                     /transl_table=11
                     /translation="MSTNETAPPVDWLTPDEDRAWRAYLRMVTAVQVGVAQDLAALGLS
                     EPDYEVLSTLSEREDGTSTLHEQAAKMGWSRSRLSRHASRMEARGLIRRAPDPTDGRGC
                     LLVLTSAGWDVLRDAAPSHVTSVRRHFVDRLTPEELATLGRIAGKLSADR"
     misc_feature    complement(19501..19517)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.76"
                     /tool="antismash"
     misc_feature    complement(19520..19533)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.15"
                     /tool="antismash"
     gene            <19661..19915
                     /locus_tag="CCZ36_RS19665"
                     /pseudo=""
     CDS             <19661..19915
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126497.1"
                     /locus_tag="CCZ36_RS19665"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="VRTRRTGTDLHVGRLAVAAPDLRGQGVGRWLLRLAESAGEGCGRI
                     VLSTGAASHRNIALYQRQGYALLPETQEAGAVDLAKAVA"
     gene            complement(20202..21188)
                     /locus_tag="CCZ36_RS19675"
     CDS             complement(20202..21188)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388482.1"
                     /locus_tag="CCZ36_RS19675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_237302706.1"
                     /transl_table=11
                     /translation="MANQSVAAGVSLAGVMAHCGGSPVGAVELLVGVIASAPAAPEPYV
                     ALAALWQGLRPDGLRESLAEDGSLSTVPAQAYFLFLEGDMDNAVMALGSVTGVRPDVAW
                     GAAPWFGDARFLGAVSAAALAEACLRTLDYGRDLDTDAMRERFAPWFHALDVVSERDPA
                     PESLAAMARLPRACGRYELSFALCDRADAVDPVMWTALARAATWRAMGNLDQAAASFER
                     ALLLEPGNWSLYLDLADLRAEQGDFAAAASLVEQGLQHEPREATLRAASAAYRTRLVGS
                     ADDLTALIALAPSLADTAYRNLLIDYACAGPQLPPGLVAEAHRIQES"
     gene            complement(21209..22237)
                     /locus_tag="CCZ36_RS19680"
     CDS             complement(21209..22237)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126501.1"
                     /locus_tag="CCZ36_RS19680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_128818245.1"
                     /transl_table=11
                     /translation="MATQHISSALPVPAVSAAYPMAKPGYGKRTAPDQQRRTRDNFALL
                     PTRERYVAGFVDHLPDGAAMSVKHLAKQLPLYGQQAISTALNALSVAGHLRRVRCSVGA
                     GDETRWVFRTFWSRTARDNEWWTAYLATETAAQTAAPAATPEAPASPDLAAPAEPPAPA
                     AVPPQRTPHQAPDAESAPPAQPTREAAPTPAYLALARLGRDDHRLALSAHDCTALEPLA
                     AQWLDRGVTTDYLTSTLTAGLPAQVDSPVGLLRRRLTDKLPPHLPTTTSTPPDAPTPTH
                     RLLVECTDCGRPGQPEALPDGLCHPCHQTHTAQDNTTPPDPTQIAAVKAHMANLRNLLK
                     PV"
ORIGIN
        1 cggcgacaac ggcgtctacg tcaccgcgcg caatgccggg ggcgcggaga ccgaccggat
       61 cgacgtcaag gtcgctccgg gcggcgaccg gcgcgccgtc gccgccgcgc tgaacaccgc
      121 cgctgccgac accggtacgc gggtggagac ccccgcggag cggccggccc cgaccggtcc
      181 ggggccggat gcccgccccg ctgacgatcc gcccgcggcc gcccccggcc cggacgaccc
      241 cacgcgcacc ggcctgcgca tgatcctcgg catcgctctg ctcgccaccg ggaccgccct
      301 ggccaacacc ctggtgatgg ccacctccca ccgggggcgc gacctcgccg tgctccgact
      361 cgccggggcc accgtcccgc aggtcctgcg gctcgtcgtg gccgaggcgg tggcggcggt
      421 cggggtgggc gcggtgctcg ggggcctggt cgccgcggtg aacctgctgg tcgtgtgggg
      481 cgcgctggcg ctgctgggcg tcacgaccgc cgtcgtggtg ccctggggaa cgctcggcct
      541 cgtcgtcgcg gccgccgcgc tcctggccgc cggctccgcc gtcctgccgg ccctgttcgc
      601 gctgcggccc cggccggtcg agctggcggg ctcccccgag tagggggcgt tccgcccggg
      661 gcagggctcg tggtcgaccg gtccagggct taggctcgcc ccatgggcag tcacccggaa
      721 cgtcttccga acccgaccac cccggccggc cgcgaggggc tcgacgccgt tctggcccgg
      781 cccgaccgcg cggtcgtcgc cctcgacttc gacggcacgc tcgccgacat cgtcccggac
      841 cccgagcagg cccgcgccca ccccggcacc gtcgccgcgc tcgccgcgct cgcgccgaag
      901 gtcgccgcga tcgccgtgat caccggccgc ccggcgggcg tcgccgtgcg ctacggcggc
      961 ttcgcgggcg tccccggcct ggagcgcctc gtcgtgctcg gacattacgg ggccgagcgc
     1021 tgggacgccg tgaccggcac ggtccgcgcc cccgccccgc atccgggcgt cacggcggtg
     1081 cgcgccgaac tcccgggcgt actccacgac gtcggggcct ggaacggcac ctggatcgag
     1141 gagaaggggc aggccctcgc cgtccacacc cggcgggcgc aggacccgca ggcggccttc
     1201 gagtcgctgc gcgggcccct cggcgagctg gccgccaagc acgggctgat cgtcgaaccg
     1261 ggtcggctgg tgctggagtt gcgcccgccc ggcatggaca agggcgtcgc gctcgccggg
     1321 ttcgtcgcgg agctggacgc ggagtccgtg atctacgcgg gcgacgacct cggggacctc
     1381 gccgcgttcg ccgccgtgga gaagctgcgc ggcgagggcc cggacggtgt ccccggcctc
     1441 ctggtgtgca gcggcagcgc cgaggtgccc gaactggccg agcgggccga cctgtcggtg
     1501 ccgggccccg ccgcggtggt ggacttcctg gcggccctgg cggaccgcct gtagacacga
     1561 ccgggcggcg gccctggccg agcggctgtg aagccgcgag gggtctcact cctgccgcag
     1621 cgcctccagc tggtccagga accaccgctg cggcgggagc gcggtcgccg cctccgcgag
     1681 ccgcttcgtg cggcccgacc gctcgtcgac gctcatcgtc agcgcttcgt gcagggcctc
     1741 cgccgtgccc gtcacgtcgt acgggttcac cacgatcgcg tcctcgccca gctcctcgta
     1801 cgcccccgcc tcccgcgaca gcaccagggc gcagccgtgg tccgagacga ccgggacctc
     1861 cttggcgacc aggttcatac cgtcgcggat cgggttgacc agggccacgt ccgccagtcg
     1921 gtacgcggcc agcgagcggg cgaagtcgtc cttgacgtgg agcacgaccg gcgtccaacc
     1981 atccgtgccg tacgccccgt tgatctccgt ggccagtgac tggaccgccg ccgtgtagtc
     2041 ccggtagacg gagaggtcct ggcgggaggg gtaggcgaag gcgatgtgga cgacgcgctc
     2101 gcgccactcg gggcgggtct ccagcagcgt ccggtacgcg tgcaggccgc gcacgatgtt
     2161 cttggacagc tccgtgcggt ccacccgcac gatcgtcttc ctgttctcgc cgacctgctc
     2221 gcgcagcgcc gccatccgct cgtccacgtc cgcctcgtgg gagcggcggc gcaggaagtc
     2281 cgcgtcggcc ccgaggccgt gcaccccgat cctggtgcgg cccgtgccgc cgaggatctc
     2341 cgtacagcag ccgatgaacg cgtccgacca gcggcgggtc aggaacgcgg cccggtccgc
     2401 gccgaggatg ccgcgcagca gctgctcggc gatgtcgtcg ggcagcagcc ggaagtagtc
     2461 caccggggcc cacggggtgt gcgagaagtg gccgatcctc aggtccgggc gcagctcgcg
     2521 gagcatgccg gggaccaggg ccaggtggta gtcctggacc aggaccgccg cttccggccc
     2581 ggcctcctcg gcgagcgcct gggcgaaggc ccggttgtac gcctcgtacg cggcccactg
     2641 ccgccggaac tccgtgtcga agaccggctc gacgggtgtc tggtacagca ggtggtggac
     2701 gaaccacagc acggagttgg cgatgccgtt gtacgcgtcg gcgtgcacct cggcgtcgat
     2761 gtccagcatc cgcacgcccg gctcgccgac cccgcggcgt accgcctcgc ggtcaccgtc
     2821 acccagcgcg gcgcacaccc acagcttgtc gtcgacggcg ctcagcccgg agacgagacc
     2881 gccgccgccg cgcttggagt ccagcgtccc gtcctcgtcg agtgtgtacg tgatcgggcc
     2941 gcggttggac gcgacgagga cctgggcatg cgaggaagac gtgtgctcgg agaccatgta
     3001 gcggaaccta gcccgttcgg gaagccgtca aacgcctcgc aggggcacgc gtcccgctcg
     3061 cgggggcacg cgtcccgccg ccccacgccg cgggtccgcc ccggacggcc gcccctcgcc
     3121 cgctcacgcc gcgtggcgct ccgcgtactc cgcgatctcc cgcatcggcg gccgctcctc
     3181 cgtgtccacc gcatgggtgc gcggtacgaa gccctcctcg ccgcgctcga actgggtcag
     3241 caccggccgc accaggtggc cccgggagag ccgcagctgg gccgtgcggt agatcgccgc
     3301 cgccatccgg cccagcgcct gaccgtcctg gtggcggtgg acgcgtacac cgacgtcgac
     3361 ctggcccagc gcgtccaggc ccaccgtgtg cagcgcgtcc acgagcagcc ccagctccac
     3421 tccgtaaccg accgggaacg gcagccgctc cagcagggac cgccgcaccg cgtactcgcc
     3481 gcccagcggc tgtacgaaac cggccagctg cggccagtgc agattgagca gcgggcgtgc
     3541 caccagttca gtgacccggc cgccctgacc tgcgctgccg ccgagcgggc ggtcgtacat
     3601 cgccttgacg aactggaccg tgggatcggt gagcagcggg ccgaccgtgc ccgagacgaa
     3661 gtccgccgag aagtccttga ggtcggcgtc cacgaagcag acgatctccc cgctggtcac
     3721 caggagtgag cgccacagca cctcgccctt gccgggcacg gccgggatcc ggggcaggat
     3781 cgcgtcccgg tggaccacgc gcgcgcccgc cgcccgggcc accgccgcgg tggcgtcggt
     3841 ggatccggag tcgatcacca cgagctcgtc gaccagccgg atcttctcca tcagctcgcg
     3901 gcggatcgtc gccacgatcg cgccgaccgt ggcctcctcg ttcagcgcgg gcaggaccac
     3961 gctcacggac gtacggcgcg ggtcggcggc ccgggcgtcg gtgagccggt tgagcgggcg
     4021 gtcgccggac gaccaggaac gcctggtcag ccagcgttcc acctcttcga gcacggtcgg
     4081 cactccctgt gtgtgatcca tctcgcggtt cggacgacta tctcaacggt ccggtgcttc
     4141 ggttacagtc ttgaacaacg cggatgaccg tcgcatgtcg gggtcggagc gcacataaac
     4201 gcctggatcg aagatccagc gccatagagc tcatccagag ggactgaggg aacggcccgt
     4261 tgaagtcccg gcaaccctcc tgccgaccgc gaggtcacgg tggggaaggt gccaattccg
     4321 tcttgcggcg aaatgcgtcg cgaggaagat gaggagaaag ggcctccgcc atcatggctg
     4381 ttcagaccat tgcaggtaat gccaccaccg cccccgtgga cctcggtccc gccgcggcgc
     4441 tttcctgccg cgagtgcggc gagcgtttcg agctcggccc cctcttcgcc tgtgcgtcct
     4501 gtttcggccc ctcgaagtgg cctacgacct gcccaccggc tccgccgagg aactgcgcaa
     4561 gcgcatcgag gccggtccgg acaacatctg gcgctatgcc ccgctgctgc ccgtccccgc
     4621 cgacgtcgcg gacaagccca acctgaaccc cggcttcacc aagctggtca aggccgacaa
     4681 cctcgcccgt gagctgggcg tcaccggcgg cctgtacgtg aaggacgact ccggcaaccc
     4741 gacgcactcc ttcaaggacc gcgtcgtcgc gatcgccgtc gaggccgccc gcgccttcgg
     4801 tttcaccacc ctctcctgct cctccacggg caacctggcc ggggccgtcg gcgccgccgc
     4861 cgcccgcgcc ggactgcgct cctgcgtgtt catcccgcac gacctggagc agggcaaggt
     4921 cgtcatggcc gcggtgtacg gcggtgaact ggtcggcatc gagggcaatt acgacgacgt
     4981 caaccgcttc tgctccgagc tgatcggcga ccccctcggc gagggctggg gcttcgtcaa
     5041 cgtcaacctc cgcccgtact acggcgaggg ctccaagacg ctggcgtacg agatctgcga
     5101 gcagctcggc tggcggctgc ccgaccagat cgtcatcccg atcgcgtccg gctcgcagct
     5161 cacgaagatc gacaaggggc tccaggagct gatcaagctc ggtctggtcg aggacaagcc
     5221 gtacaaggtc ttcggcgccc aggccgaggg ctgctccccg gtctccgccg ccttcaaggg
     5281 cgggcacgac gtcgtgcggc cccagaagcc gaacaccatc gccaagtcgc tggccatcgg
     5341 caacccggcc gacggcccct acgtcctcga catcgcccgg cgcaccggcg gcgcggtgga
     5401 ggacgtcacc gacgagcagg tcgtcgacgc gatcaagctg ctggcccgca ccgagggcat
     5461 cttcggcgag acggcgggcg gggtgacgct cggcgtgacg aagaagctca tcgaggccgg
     5521 tgtcatcgac ccggcgctca ccaccgtcgt cgtcaacacc ggcgacggcc tgaagacgct
     5581 cgacgcggtc tccgccacct cgcaggccac ggccaccatc aagccgagcc tggacgcgtt
     5641 ccgcgccgcg ggcctcggca ccgcctgacg accaccccgt aacgaaggaa gaagggcacc
     5701 accatgagcg tcaaggtccg catccccacc atcctccgta cgtacacggg cggccaggcc
     5761 gaggtgccgg cggagggcac gaagctctcc gaggtcatcg agtccctgga gaaggaccac
     5821 ccgggcatcg cggcccgcgt cctggacgac cagggcaagc tgcgccgctt cgtgaacgtg
     5881 tacgtcaacg acgacgacgt gcgcttcgag gggggcctgg acgcggccac cccggacggc
     5941 gccggcgtct cgatcatccc cgcggtggcc ggcggctgct gaaccgcccg gggccgctcc
     6001 acggcggccc ccgccgcacc tctgtgtgac ccctgttgcc ccctccgcga gagaagcgga
     6061 gggggcaatt ctgcatggtt gagcgcggta cagttgggga agccccatcc gctgcccgtg
     6121 ccgcccgcat atgagaatgc gcccggcccc gataagaagc agccaaagta cctgaacctc
     6181 ttgcggcata agtgcccttt gcctggcccg acttgcccgt aaatctcagc aaacccgcat
     6241 attcgcgtgt tccgccgcgc ccggaattct cgtccgattg acctgttgca gagggcagtt
     6301 gggcggatac attcagccgc ggtcgacgcg ctgcggcgcc gcgcaccctc tcctgtcgga
     6361 gggtgagttc cgacccgggc ccgcgaagtg cggtcccgtg caagggccag taatagggga
     6421 gttaggcatg gctcagggca ccgtcaagtg gttcaacgcg gagaaggggt acggcttcat
     6481 cgcggtcgac ggtggtgcgg atgttttcgt ccactacagc gcgatccaga tggacgggta
     6541 ccgcaccctc gaagaggggc agcgagttga attcgagatc tcgcagggcc agaaggggcc
     6601 ccaggccgac atggtcaagc tcgccgtcgg ctgagctcgg cgcggtcgtc cgacgacacc
     6661 actcacgcac gtagggcccg accccgggat cggcgaattc caggggatcg ggccttacgc
     6721 gcgttcaagg gggggcgacg acgtgcgcgc gtccgggagc cggtcgcgct ccgcgccctc
     6781 gaccgcatgg cgggcaccgg ccgaaggcgc ttgcactctc gggggtcgag tgctaatcat
     6841 tggcgttagc actctccagg tgagagtgac agaaacttgg accgggccgg tgaggcccgc
     6901 aggcgcggtg gggcaaggaa ccaccacgca cgcaggccgt ccgtcgcggg cgcctctcgg
     6961 tccggagcaa tccacccctg tccgggagga ccacttcaca tggccaagat catcgcgttc
     7021 gacgaggagg cacggcgcgg tctcgagcgc gggatgaacc agctcgccga cgccgtcaag
     7081 gtcaccctcg gccccaaggg ccgtaacgtc gtcctcgaga agaagtgggg cgcgcccacg
     7141 atcaccaacg atggtgtttc catcgccaag gagatcgagc tcgaggaccc gtacgagaag
     7201 atcggtgcgg agctggtcaa ggaggtcgcc aagaagacgg acgacgtcgc cggcgacggt
     7261 acgaccaccg ccaccgttct cgcccaggcg ctcgtccgcg agggtctgcg caacgtcgcc
     7321 gccggtgcca acccgatggc cctcaagcgc ggtatcgaga aggccgtcga ggccgtctcc
     7381 gccgctctgc tggagcaggc caaggacgtg gagaccaagg agcagatcgc ttcgaccgcc
     7441 tccatctccg ccgccgacac cgagatcggc gccaagatcg ccgaggcgat ggacaaggtc
     7501 ggcaaggaag gcgtcatcac cgtcgaggag tcccagacct tcggtctgga gctggagctc
     7561 accgagggta tgcgcttcga caagggctac atctcggcgt acttcgccac cgacatggag
     7621 cgtatggagg cgtcgctcga cgacccgtac atcctgatcg tcaactcgaa gatcggcagc
     7681 gtcaaggacc tgatcccgct gctggagaag gtcatgcagt cgggcaagcc cctgctgatc
     7741 atcgccgagg acgtcgaggg cgaggcgctc tccaccctgg tcgtcaacaa gatcaagggc
     7801 acgttcaagt ccgtcgccgt caaggccccg ggcttcggcg accgccgcaa ggccatgctc
     7861 gcggacatcg ccatcctcac cggcggcacc gtgatctccg aggaggtcgg tctcaagctg
     7921 gagaacgccg gcctggacct gctcggccgt gcccgcaagg tcgtcatcac caaggacgag
     7981 acgacgatcg tcgacggcgc cggtgacagc gaccaggttc agggtcgcgt caaccagatc
     8041 cgtgccgaga tcgagaactc cgactcggac tacgaccgcg agaagctcca ggagcgcctc
     8101 gcgaagctgg ccggcggcgt ggccgtcatc aaggccggcg ccgccaccga ggtggagctc
     8161 aaggagcgca agcaccgcat cgaggacgcg gtgcgcaacg ccaaggccgc cgtcgaggag
     8221 ggcatcgtcg ccggtggtgg cgtggctctg ctccaggcct cggccgtctt cgagaagctc
     8281 gacctcacgg gtgacgaggc gaccggcgcc aacgccgtga agctcgcgct ggaggccccg
     8341 ctcaagcaga tcgccgtcaa cggtggtctc gagggtggcg tcgtcgtgga gaaggtccgc
     8401 aacctgccga tcggtcacgg cctcaacgcc gcgaccggcg agtacgtcga catgatcgcc
     8461 gagggcattc tcgacccggc gaaggtcacg cgctccgccc tgcagaacgc cgcgtccatc
     8521 gccgcgctgt tcctcaccac cgaggccgtc atcgccgaca agcccgagaa ggccggcgcg
     8581 gccgctccgg gcggcatgcc gggcggtgac atggacttct gatcggttcc ggctccgcgc
     8641 cggtcgatcg aggttccgcg tacgtcgagt acgcaggtac gtcccccagg ggcggtatct
     8701 ccttcacgga ggtgccgccc ctggggcgtg tccggggaca atggggcgag gccgcggtcg
     8761 tacggacacg gggggcggta cgggcatgag cgtgcgtgct acggggagaa cgggcggccg
     8821 ggggcggctc aagggggtct cgctcgtcgt gggcggggcc gtgctgttcg cggcggggct
     8881 gttcgtcgtg gtggccggga cgggtctctc cggcgccctc ggtatgcggg tggagacctt
     8941 cggccgcatc gactgcgacg acacccgcac cgagaagggc cagaccgtct ggcactgctc
     9001 cggcgagacg cccgcccagc agcgcgccaa cgacgcggag cgcgagaggg tggcccacga
     9061 ggccctgcgc gcccatgtgg acggcgtgcc ccggtccgcg gagatcagcc gcagcaggat
     9121 cctcttcgcc gaccacgacg gccggatgga ccccgaaacg atcaccgcga cccaggtgtt
     9181 cgacggcgga cgctggtacg cccactcctc gatgctcgtc ggctacggca tgatcccgct
     9241 gttcctgggc gcgggaacgg cggcctgggg cggctaccgg ctgcgcgcgg ggtagcggac
     9301 ggggcagcgc gggccctcgg cgtggccgaa tgactacttg ccgtggccac tcccgtacgg
     9361 cagtgcgttt cggcgcaccc ctgccgaggg cggtggcgcg cccgggctcc ctggggtaaa
     9421 gcggtcgcgg agccgccccg cggcccgctc cggccggttc cccggggcct cctgtcggcc
     9481 gctccccgtc gtggcagctc accgtagggt ccggcgacca cgtccagtca ttggtccagt
     9541 ccacgaagcc cctccggcgg ggcggtgtgc gactgcacac ggcggacgtc agggcgaccg
     9601 ggcccgggcg gaggcccccg aaccggtccg cgacgcacct cgccgctcgc gctatccagc
     9661 caacttcatg cggtaagtcg gaatcacgcg taccggttca acggtcggac atgatggccc
     9721 tggtgttcgc atgacgaaca cccgtcgcac cagtaactcc agttatgcag aagtcctttg
     9781 ggcataacgg gcgtcaaccg cacagaaggg aaggtgtcat gaagccgcag cagcagcaga
     9841 agaaggctta cgtgaagccg tcgatgttcc agcagggcga cttctcgaag aagaccgccg
     9901 gctacttcgt cggctcgtac aaggagtact ggagccggcg gatcatctga tccgccgatc
     9961 cgtttcctgt gcaccgcgtg agaacttccg aaaggtgaag atgcccggcc agttgcgtga
    10021 ctacttcgtc gtcctgccgg acagcgcggc gggagcggca gcggccgggc agcttcccgt
    10081 accgggagag gctgccgggc ggtccgccgc gccggacgcc accgggcccg cccgggaggt
    10141 gggcgacacc ctgaccgtcg cccacccctc gggccggccc tggatcgtcg cccgcccgct
    10201 ggtccgccgg gtcagccaga tcgcccgggg ctcggacgcc ctcgtcctca tcggcccgga
    10261 ccgcgtcccc gacgccgtac tcgccgggat tctggagggc gcccgcgacc ggaccggcct
    10321 ggagcgccgc ctcgcccggc tgcccggcct ctaccacgtg gtcgcccggc tgtccgggca
    10381 gagctggatc cggggcaccg ccaccggact ccgccggatc taccacgccc ggcacccggc
    10441 ggccggaacc atcgcctccg accgccccgc cgtcctggcc cgcctgatcg acgcgcccct
    10501 ggacgacagc gcgctggcgc tgcggctgct ggacttcctg ccgcaccccc tgagccgccg
    10561 ccccgtgtgg cggggcatcc acgagaccgg tgccgggcac ggcctggccc tgcccgccgc
    10621 agcaccgggc acggccgccg tccccggtcc cacggagcat cgctggtggg agccgccgcc
    10681 cggcgaactt cccctggcgg agggggcgcg aaaggccggg gacgccatcg cggcctccgt
    10741 acgggcccat gtcggcggcc tggaccggat cagctgcgaa ctctccggcg gactggactc
    10801 caccgccctc gccttcgccg cccgcgagac cggccccgcg tcgctgtccc tgctgaccgt
    10861 ggccgcccgg gaccgctaca gcgaggacga gacctgggcg cgcagagcgg tcgaggcggc
    10921 aggcggcacc cccgcgacgg cgacccggaa cacccactcc gccgccaccc ggggccgccc
    10981 ctccgccccc gccctggacc accacgtcat ccccgccggc gacgccccgt acttctacgc
    11041 cgatctcgcc tccaccgcag ccgagttgaa cgacgaaccg ctccccgtcg cccccggccg
    11101 ggcccgcgcg gaactgctcc tcggccgcgc ccacgccacc ggctcccgct accacctcac
    11161 cggctacggc ggcgacgaga tcttcctcgg cctgccccac gcctaccagg acctcttcca
    11221 cggcagcccg ttcaccgcct ggagccacct ggggggcctg cgccaccagc tcggctggcc
    11281 gctcctgccc acggtgaagg cgctgttcga ccgttcgacg ttcccccgct ggctcgccgg
    11341 ggcggtcgcc gccgcacccc agccggtcgc ccgggccccg ctgttctcct ggggcgtacg
    11401 gcagtccctg cacccctggc tcaccgaaca cgcgaccgcc ctgatcgccg aggagttccg
    11461 ggccgccgcc gagcaggccg aaccgatcga cccgcggcgg ggacggcacg tcgacatcga
    11521 cggcgtacgg atgggggccc ggcacttcca ggcgatggag gacatcggca tgacgatcgg
    11581 gctgccggtc gccgccccct tctacgacga ccgggtcctg gaggcgaccc tcgcggtacg
    11641 cctgccggag cgcatcagcc cctggcgcta caaaccgctc ctcgtcgagg cgatgcgcgg
    11701 ggtggtgccg gacgcgctgc tggcccggac gacgaaggac cacatggcct ccgacgaaca
    11761 ccagggcctg cgcgaacacg ctccggaact ggtcgagttg tggacgggct cccgcctcgc
    11821 cgaacacggt ctggtcgacg cccgccgact gctgcgactg gcggccgagc ccttctcgcc
    11881 ggtcctggtc gaacactcca tcagctccac cgtggccggg gagacctggc tccgcacggc
    11941 cgagaacgcc tggcccccac ccgagccgtc cctccccacc acccccagcg aggcatccct
    12001 gtgaagctca gaaaaggcat cgccgtcacg accaccgagt acggcggcgt tctcctcgac
    12061 gagaagagcg gcagctactg gcagttgaac gacaccagcg tcatcgtggt cgagaccctc
    12121 gcggcgggcc gcgccccgga ggccgccgtc gagcggatcg tcgccgagtt cgacgtcgag
    12181 cgggccgagg ccgagtcgga cgtcgcggag ctgacccgcc ggctcgtcga ggcgaggatc
    12241 ctgcggccat gaccaccgag atgacgatgc cccgccgggg cgccggggcg ggtgggatac
    12301 ggctgcgcac cgccatcgcc gccgcgttcg tcctggcccg gctcaagccc ggccggctgc
    12361 gccggacgct cgcccggtgc gcccggggcg cgcgcccggc cacgtacgcc gagacgtcgg
    12421 aggtgctgga cgcggtcacc gccatcagcc gccgctgcgc gagccgttac ggctgcctgc
    12481 cccgctcggt ggccgtcgcc ctggcctgcc ggatgtccgg tgtctggccc gactggtgcg
    12541 cgggggtgtg ggcgaccccg ccgttctccc cgcacgcctg ggtgcaggcg gaaggacgta
    12601 cggtcgggga gcaggcagag gccgccgatc tgcgtcctct gatggtggtg acggtacgcg
    12661 agggggtcca gggtgagcgc ggtgacgggg acgtcggcgg gggcggggca ggcgggcccg
    12721 ggcccggttc cggggagatc acctgagagc acggagcgac cggggccgga gacacctccg
    12781 gaccggactg tgcccgcccc ggccgccgcc cccacgcctc cgcccgcccc cggcccttcg
    12841 cccctccgcc tgctcctggc ccgggtccgc ccgcaccggg gcgtcctgat ccgggcgggc
    12901 ctgctctcgc tcgccgggtc cggggcgggt ctggcgatgc cgctgatggc gaagcacgcg
    12961 gtggacacgt tcgccgaagg ccgctcgccc gtggccccgc tcgtcgcgct gaccgcgctc
    13021 gtgctggccg gggcctgcct ctccgcgtac gggagcttcc tcatgtcccg gacgggagag
    13081 ggcgtcgtcc tgcgcgcacg cgaccaactg gtgtgccgca tcatgcggtt gaaggttccg
    13141 gcggtggacc ggctgacgcc cggcgacctc cagtcacggg tcacgagcga cacgaccctc
    13201 ctccgtacgg tgctctccag cggacttgtc gagtcgttca acagcgtcct gatgctgctg
    13261 ggcacgctcg ctctcatggc gtacatggac ctgacgctgc tcggtgtgac gctggtggtc
    13321 gtcgtcggca tcggggccgt gacgtccctg ctgatgccgc gcatccagcg ggcgcagctc
    13381 aaggcgcagg agtccgtggg tgcgatgggc gcggccctgg accgggtgct ccaggcgttc
    13441 cgtacggtca aggcgagcgg ggcggaggag cgggagaccg cggtggtcgc ggcggcggcg
    13501 cggcatgcgc acgaccgggg cgtgtcggtg gcgaagtggg cctcggtcac cgaggtcacg
    13561 atgacgatgt cgatccagct ggcgttcctg gcggtgctgg gcgtcggcgg cgcacgggtt
    13621 gcgtccggct cgctggagat ctcctccctg atcgcgttcc tgctgtacct cttctacttg
    13681 ataggcccga tcggcggcct ggtcgagggc tggacgggcc tccagagcgg gctggcggcg
    13741 gtgcgccgga tcgacgaggt ggagtcgctg cccggagaac cggccgagga gccggtcgcg
    13801 ttgacgaagg cggacggcgg cccgctcggg gtcaccttcc aggacgtgac cttcgactac
    13861 ggggacgagc gcgcccccgc ccaccaaagg gtgacgttcg acgtgccggc cggcgggatg
    13921 gtggcgctgg tcggcccgtc cggggcgggc aagtcgacgg tgttcagcct gctggagcgc
    13981 ttctacgacc acgaggccgg cacgatcacc gtgggcggcc gggacatccg cgactggccg
    14041 ctggccgaac tgcggggctc actggcgtac gtggaacagg acgcgccggt gctcgccggg
    14101 acgctgcggg agaacctcct cttcgccgcc ccggacgccg gggagagcga gctgacggcc
    14161 gcggtcgccc gcacccggct ggacgccctg gtcgagcggc tgccggacgg cctggacacg
    14221 gcggtcggcc accggggcgt caccctctcc ggcggcgaac gccagcgcat cgccatcgcc
    14281 cgggccctgc tgcgccgccc ccggctgctc ctcctggacg aggtgacctc gcaactggac
    14341 gcggtcaacg agcaggcgct gcgcgatgtg atcctcgaac tcgccgagcg cacaacggtg
    14401 ctggtgatcg cgcaccgcct gtccacggtc cggcacgcgg accgcatcgt ggtcctggag
    14461 gagggccggg tgcgcacggc gggcacgcac gaggagctga tggccgggga cgagctgtac
    14521 cgcgagctgg cgacgaccca gctggcggcg gaggcgcggt gagagatccg gagggcgcgg
    14581 acgacggggg cggcgaggcg gacgcggacg gtgggtgtgg cgcgaacgag gaactgagag
    14641 gcaggttcgc cgaggaggtc gactggtcgc aggctgccgg ccgtcccgta ccgcgaaacc
    14701 tgttgaggaa ggatcgcggc atgacgcata caagctcttc tccctggaag tcgtcccccg
    14761 agttgtcgtt ccggcgggcg ggggaggggg atctggccga gctcgtgcgc ctccgggacg
    14821 atgccgcgcg ctggcagatc gagcgcggca tcgaccagtg gaaacccggg gagctggggc
    14881 cggaacactt cggggcgcgg ttgcgtgcgg gcgaggtgtg gatcgctacc gccggtcccg
    14941 gcgggccgaa cgccggggcg tgggagctgt ggtgggagga cgagccggcc tggggcgtcc
    15001 agccgccggt ggcgggctac gtccaccgcc tgatgaccga ccggcgcacc gccccgcccg
    15061 gggccgggcg tgcgctgctg gcggaggccg agcgccggat cgccgcgtcg ggccggccgc
    15121 tgtgccgact cgactgcctg acgtcgaaca cccggctccg ccgctactac gagcaggcgg
    15181 ggtacgtggt ggtcggcgag caggcgggaa agaacgggga cggcggccgg acgtacgggg
    15241 tgaccctgtt ggagaagcgg gtgggggcgg gttgagcggc ggctgaaccc ccgccggagc
    15301 gggttgagcg ctggctgaat ccccgcccgg caggctgagc ccggctgtga cgaccgtcac
    15361 ccggatgctc ggtcgacgct gtagaccgga tgcccgacgg caggcgtata cccggtgaag
    15421 cgaaagatcc gggagcaact tttgaccgtc gaggagttcg aagagttcta cgcccaggcg
    15481 gtcgcacgtc tcaccggcca gttgtacgtg atgaccggcg acctccagga ggcgcaggac
    15541 gtcgtgcagg aggcgttcgt caaggcgtgg gtccggcggg ggcggctgga gcgggacggg
    15601 cagcccgagg cgtggatccg tacggtcgcc tggcggctgg cggtgagccg ttggcgtttc
    15661 cggcggcggt cggctgacgc gtggggccgg gggagcggtg gggcggagca cgtcgcgccg
    15721 ccggacccgg accatgtggt cctggtcgac gcgctgcggg agctgcccgc ccagcagcgg
    15781 cggacgctga ccctgcacta cctgtgcgac ctcacggtcg agcagatcgc cggggagacc
    15841 gggctttcca ccagcaccat caagacgcat ctggtccgtg gccgggcggc gctcgcccac
    15901 cggctgcgcg acccccgcat cgaggaggct cctgatgtct gaaccgcggg atccgaagga
    15961 gccgcaggat ccgttgcggt ccctgttccg ggaggccggt gagttcgggc aggccctcac
    16021 cgccccggac accgcgtcga gcatcacccg gcgcggcatg cgcgcgcagc gacgccggat
    16081 ggccgtggtc gcggtggggg tgtgcctggt cgtcggcggg ggcggcgcgg tcgcggtggg
    16141 cctgctgccg gtgcggccgc agccggtggc cccggccacg aacccgtcgc ccagctaccc
    16201 ctcgcccgta ccgtcggagg gcctgcccac cgagcagccg tcaacgccgc cgtcgccgag
    16261 caccacggtg ccggggagcg cggggacgcg ggggcggagg ggccgtcggg ccggaccacc
    16321 gagccgggcg ggccgcccac gcgtacgcgt acgagcacga cgccaccgac ggcatcggcg
    16381 acaaccgatg ggggcgcgtc gacgccctga cgccgccgcg cggcctcgac ccttcccttc
    16441 tcctcttctt cccttccgtg ccccggcggc tctccgggcg atccggcgcg ccccgacgta
    16501 cccgcgaggc gcgcccgaaa ggtgcctgcg ttgtccacgc tctccccggg gctgcggccg
    16561 tctcctgtcc gtcccgcacc cgaaccccgg gcggccgagc tccggttggc acggttccgc
    16621 ctggctcccg ccgatcgcgg catcctgtgg ctctatctcc tgacccgcgt ctccctgtgg
    16681 atcacggccc acttcgcccg ctggctgttt cccgcgcagt ccggcgtacg ggaggcggcc
    16741 ccggtcctgg cgccgttcca gcagtgggac gcgaaccact acctccacat agcccgcgac
    16801 ggctacttcc cggcgggcgc gggaccgtgg acgagcggct gggacaaccg ggaggcgttc
    16861 tttcccggct accccctcct gctccgcgcc gtgcacacgg tggtgcccca ctggacggcg
    16921 gccgggctgc tgatctcgtt cgtcgcgggg gccgttgccg tactggccct ggcccgtgtc
    16981 gcgcgggcgt atctgccgga ggacgcggcg ggcccccgta cggctgtcct cttcctgctc
    17041 tcgccctgcg cggtgttcct ggcggcgggt tacacggagg cgctgttcct cgcgttcgcg
    17101 ctgcccgctt ggctcgtggc gatgaagcac cggtgggcgc tcgccgccgt actgaccacg
    17161 tcggcgacgg cggtgcgcgt gagcggcctg ttcctcgcgg cggccgtcgg gctgctgttc
    17221 ctgctgtccg tacgtgcggg cgagggccgg cggaggtggc gtgcggcggg ctggacgctg
    17281 cttccggcgc tgcccccggc cgcgtacagc tggtatctgc acgcgcggac cggtgactgg
    17341 atggcctgga agcacgcgca ggaacgcggt tggtaccgca cgttccacgc cccgtgggag
    17401 gcgtgggcga acacctggac cggggcgttc ggcggtacgc agtcgaccgg ctacgcgttc
    17461 atgttccagg cggagttggc ggcgatggtg gtggggctcg ccctggtggt gctgctggta
    17521 cgccgacgcc gctggccgga agcggtgtac gtggccctca gtctctgggc gctgggcacc
    17581 tcgtactggt acacgtccgt cccgcgcgcg acgctgctgt ggtggccgct gtggatcggc
    17641 ctggcggcgc tgagcctgcg tcggccgtgg ttcaggacgg cgtacctgtg tgtggcggcc
    17701 ccggtgacga cgctcgtcgc gctgacgttc ctgacgggga gatgggcggg gtgaggaggc
    17761 gggggccggt tctcccggcc ggtttcccga acagtcccgg cgttttcccg aacagccccg
    17821 ccggttcccc gaacagttcc cctccggggc gtgacgggca gtcggtgtac gtgcacgggg
    17881 acggtcagag cacggcgagc cgttccacca ggagatccag tcgctccccc gcgccctccg
    17941 gcaggagccg ccccgcccgg gtcagggtgg ccagcccgtg cagggccgac cagaagagtt
    18001 cggtgaacag cgccgggtgc acgccctccc cggcgacctc gccgagggtc tccagcagcg
    18061 cggcgaaggc gtccttcagc ggttccgggg tgtcctcgcg cgcgaaggcc aggccgccgt
    18121 cgagctggaa cagggcgtcg tagaccgcag ggttccgctc ggcgaactcc aggtacgcgt
    18181 gggcgagggc ggcgacccgg gtgcggcggc cgtccgcgcc cgagctggcg gcccgcagcg
    18241 ccgaagccat ctcggtggcg ccttcgagcg cgaccgcgcc gatgatctcg cgcttgccgc
    18301 ggaagtggct gtagaggacg ggctggctgt attcgatgcg ctcggcgagc cggcgcgtgg
    18361 tgaccgcgtc ccacccctgc tggtcggcga gttcgcgagc cgtcgccacg atgaggcgct
    18421 cgcggttcgc ccgttcccgt tccttgcgtt cctggaccga catgtaccga ccctagcatc
    18481 gctagacaat caagcggcag caggtctagc gttgcaccat catctagcat cgctagattc
    18541 cgagaggggt catcatgctc gacgtacttg aggtcgtcac caccgtgatc gtcggactgc
    18601 tggtgggggt ggagttctcc gtcgcctttg tcatcaaccg gatcctggac gcgctgcccg
    18661 acgacagtgc tcagcgcggg cgaagccacg ggggccggat gcttggggcg gtgatgccgt
    18721 tctggtacat cggttcactc gtcctgagcg cgatctgggc cgtggccggg tggggcgagc
    18781 cgggcgcggg gctggtcgtc gcggcgggcg cgctgttgct cctcggcgtg ctcatgtcgc
    18841 ttctgctgct cgtcccgatc aacgaccggg gtaagacgtg gacctcggag aaccggcccg
    18901 aggactggaa agagcagatg aaccgctggg accgctacca ctacgcgcgc gtggccgtcc
    18961 tcatcggcgc cttcgcgtcg ctggtcgcgg ccctcgcctg aggcgggccc ggcaccgccg
    19021 cctcctcccg gccgccccta ccggtcggcg ctgagcttcc cggcgatccg gcccagcgtg
    19081 gcgagctcct ccggtgtcag gcggtcgacg aagtgccgcc gtacggaggt gacatgggag
    19141 ggcgcggcgt cccgtagcac gtcccagccc gccgaggtca ggacgaggag gcagccccgg
    19201 ccgtcggtgg ggtcgggggc gcggcggatg agtccgcgtg cctccatgcg ggaggcgtgc
    19261 cgggacaggc gactgcgcga ccagcccatc ttggcggcct gttcgtgcag cgtgctggtg
    19321 ccgtcctcgc gctcggacag ggtgctgagc acctcgtagt ccggctcgga caggccgagt
    19381 gcggccaggt cctgtgcgac gccgacctgg acggcggtca ccatgcggag gtacgcccgc
    19441 caggcgcggt cctcgtcggg ggtgagccag tcgaccgggg gagccgtctc gttcgttgac
    19501 atgtaaccaa cctaccggct tatttcattt ctatgacaac gaaacggttg cgcgtcctcg
    19561 ttctggtctg cagtacccgc cccaacgcgc tcggccccgc cgtggggcag tggctgaccg
    19621 acgtgctcgc acccggcgcc aagctcctcg gcgcagacct gtccgcaccc gccgcaccgg
    19681 caccgacctc cacgtgggac gcctggccgt cgccgccccc gacctgcggg ggcagggcgt
    19741 gggccgctgg ctgctgcgcc tggccgagtc ggcgggggag gggtgcggcc gcatcgtcct
    19801 gtcgaccggc gcggccagcc accgcaacat cgcgctgtac cagcggcagg ggtacgcact
    19861 gctgcccgag acgcaggagg ccggcgcggt ggatctggcg aaggcggtgg cgtgagcgca
    19921 cgccgtcacc ggcgcgatct gcgacgacgc cgggtcgggc acaccgtcac ccgcccatgg
    19981 tccggagtcc ggcgtcaaca aggacccctg ccccggcgag agcgaaggcg ccaccgatca
    20041 ctctgcatgt gacgacactg gcgggccacg accggtaggc gtaggacatc gcctggaacc
    20101 gttcggccgc ccctcggacg tttgcggcca ggagcccccc gcccacgagc gcgacgccac
    20161 cccacatcag ctcgaacatc tgactgttca cgactacccg ttcagctttc ctggattcgg
    20221 tgggcctcgg caaccagtcc cggagggagt tgcggtcctg cgcacgcgta gtcgatcagc
    20281 aggttccggt aggcggtgtc ggcgagcgag ggggccaggg cgatcagggc cgtgaggtcg
    20341 tcggccgagc cgacgaggcg tgtccggtag gcagcgctcg ccgcgcgcag ggtggcttcg
    20401 cgaggttcgt gctgcaggcc ctgttcgacg aggctcgcgg ctgcggcgaa gtcgccctgc
    20461 tcggcacgca ggtctgccag gtccaggtag agggaccagt tgccgggctc caggagcagg
    20521 gcgcgttcga aggacgcggc agcctgatcc aggttgccca tcgcgcgcca ggtggccgct
    20581 cgcgcgagcg ctgtccacat gaccggatcg acggcgtccg cacggtcgca cagggcgaag
    20641 gacagttcgt accggccgca ggcccggggc agccgggcca tggcggccag cgactccggt
    20701 gccgggtccc gttcggacac cacgtcgagg gcatggaacc agggcgcgaa ccgctcccgc
    20761 atcgcgtcgg tgtccaggtc acgaccgtag tccaacgtcc gcagacacgc ctcggccagc
    20821 gccgcagcac tcaccgcacc gagaaaccgc gcatcgccga accagggtgc ggcaccccag
    20881 gcgacgtcgg gccgcacacc cgtgaccgaa ccgagggcca tcaccgcgtt gtccatgtcc
    20941 ccttcgagga acaggaagta cgcctgcgcc ggcacggtac tcaaggagcc gtcctctgcg
    21001 aggctctccc gcaggccgtc cgggcggagg ccctgccaca acgccgcgag ggccacatag
    21061 ggctccggag ccgccggcgc ggaggctatc acccccacca gaagctccac ggcacccacg
    21121 gggctcccgc cgcagtgcgc catcacaccc gcgagactga ctcccgctgc tactgactga
    21181 ttggccatcg ccagagagta cccgcacctc agacgggttt gaggaggttg cggaggttgg
    21241 ccatgtgggc tttgacggcg gcgatctggg tggggtcggg gggtgtggtg ttgtcctggg
    21301 cggtgtgggt ttggtggcag gggtggcaga ggccgtcggg gagggcttcg ggctgtccgg
    21361 ggcggccgca gtcggtgcat tcgacgagga ggcggtgggt gggggtgggg gcgtcgggtg
    21421 gggtgcttgt ggtggtcggc aggtgtgggg gcagtttgtc ggtgaggcgg cggcggagga
    21481 gtccgacggg ggagtcgacc tgtgcgggga gtccggcggt gagggtgctg gtgaggtagt
    21541 cggtggtgac gcctcggtcg agccattgcg ctgcgagggg ttcgagggcg gtgcagtcgt
    21601 gggcggagag ggccaggcgg tggtcgtcgc ggccgaggcg ggcgagggcg aggtaggcgg
    21661 gggtgggggc ggcttcccgg gtcggctgcg cgggcggcgc tgactcggcg tccggggcct
    21721 ggtgcggggt gcgttggggc ggtacggcgg cgggggccgg gggctccgca ggtgctgcga
    21781 gatctggtga ggcgggtgct tccggcgtgg cagcgggcgc tgcggtctgg gcggcggttt
    21841 cggtggcgag gtaggcggtc caccactcgt tgtcgcgggc ggtgcgggac cagaaggttc
    21901 ggaagaccca gcgggtttcg tcgccagcgc cgaccgaaca ccgtacgcgc cgcagatgtc
    21961 cggcgacgga gagggcgttg agggcggtgg agatggcctg ctgcccgtag agggggagct
    22021 gcttggccag gtgcttcacg ctcatcgcgg caccgtcggg gaggtggtcg acgaatccgg
    22081 cgacgtaccg ctcacgggtc ggcagcaagg cgaagttgtc acgcgtgcgg cgctgttggt
    22141 cgggtgcggt gcgtttgccg tagccgggtt tggccatcgg gtacgcggcg gagactgcgg
    22201 ggacgggcag ggcggagcta atgtgctgtg tagccacggg atcgtccttc tagggtgctg
    22261 gatcttgtgg tgagaccccg gctcggtctg cgaaaccgtg tcggggtcgt tcagttctcg
    22321 caccgtaagc ggcggtcacg ctgcgccgca agctgtcacg attagtcata ccaactggcc
    22381 gtgacggggt ggggaggtgg gggaggtttt cccaaccacc ctcttctacc cccgggttaa
    22441 agaaggagct cggaccccgg gtctcgcatc ccgacgcccg aaatcccggg tcccgagctt
    22501 cgggccggag ccccgttcac gtacccccgg aagagtgacc tgcccgtccc cgaagcccgg
    22561 gcctcgcggc ccgggacccg agtttcgagg ccttcgccgt gtccttgtcc agggcggtgc
    22621 gcagcctctt gatgctttcc tgcgcgagat ggtcatcggc gacgcggatc gcatggcggg
    22681 ttcgacctct ggtcgggagg acgcacattc cttgcccaca gggacgggct tcagagagct
    22741 tcccgg
//
