LOCUS       NZ_CP021707            15213 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces sp. S063 chromosome, complete genome.
ACCESSION   NZ_CP021707
VERSION     NZ_CP021707.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S063
  ORGANISM  Streptomyces sp. S063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Complete genome sequence of Streptomyces sp. S063, a producer of
            anti-complement compounds and various secondary metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAY-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:19:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,905
            CDSs (total)                      :: 6,817
            Genes (coding)                    :: 6,244
            CDSs (with protein)               :: 6,244
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 574
            CDSs (without protein)            :: 573
            Pseudo Genes (ambiguous residues) :: 0 of 574
            Pseudo Genes (frameshifted)       :: 432 of 574
            Pseudo Genes (incomplete)         :: 192 of 574
            Pseudo Genes (internal stop)      :: 13 of 574
            Pseudo Genes (multiple problems)  :: 61 of 574
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:16:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4077726
            Orig. end                         :: 4092939
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021707.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Xinqing Zhao, Life Science
            and Biotechnology, Shanghai Jiaotong University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..15213
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /product="ectoine"
                     /region_number="13"
                     /rules="AfsA"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..15213
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /detection_rules="ectoine_synt"
                     /kind="neighbouring"
                     /product="butyrolactone"
                     /product="ectoine"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..10882
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10882
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5882](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5882
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     misc_feature    complement(683..698)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.92"
                     /tool="antismash"
     misc_feature    complement(892..905)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.49"
                     /tool="antismash"
     misc_feature    902..915
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.36"
                     /tool="antismash"
     misc_feature    969..982
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.22"
                     /tool="antismash"
     gene            1019..1498
                     /locus_tag="CCZ36_RS18795"
     CDS             1019..1498
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0019239 - deaminase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1240: riboflavin biosynthesis protein RibD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763177.1"
                     /locus_tag="CCZ36_RS18795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleoside deaminase"
                     /protein_id="WP_069735582.1"
                     /transl_table=11
                     /translation="MGTHDSELMGFAHEAIRLSREHVAQGGIPFSGVVVGGGRILGTGF
                     NRVREDNDPTAHAEVVALRQATARHGMRAVAGATLIASGEPCALCYMAARFAGIGHIVH
                     TADRRTAARYGFDYTGSYSLFAEDPEHWPIKVTALQLPEAEVPFQDFLTMSRPRH"
     gene            1581..1901
                     /locus_tag="CCZ36_RS18800"
     CDS             1581..1901
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967532.1"
                     /locus_tag="CCZ36_RS18800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_030722115.1"
                     /transl_table=11
                     /translation="MHWLYLAIAVAFEIAVAIAAGKAEGFKNRKWTAITLISGALATFF
                     LSKSLLTFDVGVGYALWTSVAGVGITILGALFFGQRLNWNKAIGIVLVIGGVVGLQLSG
                     SA"
     gene            1983..2399
                     /locus_tag="CCZ36_RS18805"
     CDS             1983..2399
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763175.1"
                     /locus_tag="CCZ36_RS18805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_069735581.1"
                     /transl_table=11
                     /translation="MSNEAKTSTNAWLSLLLAGVFEIGYALAVGGSEGFTVLTWSLVAV
                     VFFLLTLYALSLALRTIEVSIGYAVWAGIGAVGAAVLGPVFFDETLTLAKGIWLSVIIV
                     GVIWLKLADRTKPETAAPAPAAQQVADRPGALQV"
     gene            complement(2533..3303)
                     /locus_tag="CCZ36_RS18810"
     CDS             complement(2533..3303)
                     /EC_number="1.1.1.47"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (11-181). E-value: 4.6e-13.
                     Score: 41.4. Matches aSDomain:
                     nrpspksdomains_CCZ36_RS18810_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452957.1"
                     /locus_tag="CCZ36_RS18810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glucose 1-dehydrogenase"
                     /protein_id="WP_079149435.1"
                     /sec_met_domain="adh_short (E-value: 5.5e-36, bitscore:
                     122.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.3e-30, bitscore:
                     105.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPGGPLLSGKVALITGASSGIGAAAGRHFAAEGAAVVLVARRAA
                     QVEEVAERIRKDGGRAVAVPGDVTRPADMERAVATAVDRFGSLDCAFNNAGYASAGTVL
                     HELPDDVFDRTLDVNLRGVWNCLRAEIPAMLEAGAGAVVNTSSVAGVRATAASAPYVAA
                     KHAVIGLTRAAAAEYGEHGIRVNALVVGGTDTEMMDSFRSTGLTVDAGFGSQGIQRRLA
                     DPVEIARAAAWLCSDAASFTTGTALAVDGGRTAK"
     aSDomain        complement(2761..3270)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CCZ36_RS18810_PKS_KR.1"
                     /evalue="4.60E-13"
                     /label="CCZ36_RS18810_PKS_KR.1"
                     /locus_tag="CCZ36_RS18810"
                     /protein_end="181"
                     /protein_start="11"
                     /score="41.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALITGASSGIGAAAGRHFAAEGAAVVLVARRAAQVEEVAERIRK
                     DGGRAVAVPGDVTRPADMERAVATAVDRFGSLDCAFNNAGYASAGTVLHELPDDVFDRT
                     LDVNLRGVWNCLRAEIPAMLEAGAGAVVNTSSVAGVRATAASAPYVAAKHAVIGLTRAA
                     AAEYGEH"
     CDS_motif       complement(3175..3264)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CCZ36_RS18810_0001"
                     /evalue="1.60E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="CCZ36_RS18810"
                     /protein_end="43"
                     /protein_start="13"
                     /score="14.3"
                     /tool="antismash"
                     /translation="LITGASSGIGAAAGRHFAAEGAAVVLVARR"
     gene            complement(3300..4019)
                     /locus_tag="CCZ36_RS18815"
     CDS             complement(3300..4019)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763173.1"
                     /locus_tag="CCZ36_RS18815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD family phosphatase"
                     /protein_id="WP_128818177.1"
                     /transl_table=11
                     /translation="MLSLRLAALNIDGVLLNDTFSPVIHQFVVSRGGTYSAALERSVFS
                     QSQHIAGQRLAAAVGGGMTGEAALAAYFEERAAHVGRHPVTITPGTHRLLLRLRSAGLR
                     TVCYGGLGKEHFDRHLGRYAHLFDGPGYVSTNDIRPGLREITEDVFGLRPAQALFVDDV
                     ARVAEEARALGTAFVGHPSAFAHSHQRTLMREAGVRHMVDRLDALDDGLLHRIDQEMST
                     GTFWSPALVAAGRERQA"
     misc_feature    complement(4008..4010)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4073..4705)
                     /locus_tag="CCZ36_RS18820"
     CDS             complement(4073..4705)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452959.1"
                     /locus_tag="CCZ36_RS18820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_128818178.1"
                     /transl_table=11
                     /translation="MAQPKQERAEQTRRALLHAAAEVFDEFGYAGASITRILKRAGVTA
                     GALYFHFGSKEDLAKAVMNSQPETLVPLVAAGGLQRLIDITLVWSWQLQRDPLLRAGVR
                     LTNEQTSVGGPANADPYEKFRAIMTGCLQDAQNDGELQPGVDPVVVAEFVVAACTGMQM
                     YSNVVSGRQDLPERTQQMWNLILPGIAVPSVITRADATPARGAAMTP"
     misc_feature    4705..4715
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     cand_cluster    4839..15213
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    4839..15213
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[9838:10213](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(9839..10213)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="2"
     misc_feature    4865..4874
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.04"
                     /tool="antismash"
     gene            5001..5882
                     /locus_tag="CCZ36_RS18825"
     CDS             5001..5882
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452960.1"
                     /locus_tag="CCZ36_RS18825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_079133914.1"
                     /sec_met_domain="AfsA (E-value: 2e-22, bitscore: 77.7,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHQWQVHKLRGEEVLLRTWTEEDSGRFVITARWPKGHAFYQPSQG
                     AYDPLLLAETVRQTVPLLSHAVHGVPREHKQAWECLDFAVEPLAALVTTAEDEVRLVVS
                     CSDVVRRGNRFAGMTMDIDVHLGKRLMGIAHTRFNDQPAAVYRRMRRGYADIDAALENR
                     LPAGPPVEPHRVGRGSPADVVLSPALGGERPGRWLLRVDTAHPVLFDHPVDHAPGMLLL
                     EAARQAARAVGGATAAVIGMRTNFVRYVELDAPAVVVAGSPAPVGPGRRRVPVSIEQDG
                     VQVFTSEVTIAG"
     misc_feature    5241..5243
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5966..6718)
                     /locus_tag="CCZ36_RS18830"
     CDS             complement(5966..6718)
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (132-191). E-value: 1e-07. Score:
                     23.7. Matches aSDomain:
                     nrpspksdomains_CCZ36_RS18830_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763171.1"
                     /locus_tag="CCZ36_RS18830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_069735577.1"
                     /transl_table=11
                     /translation="MTHDLKWSDAPPGEVRDQVGVWIVRAPAGQRLPPDGSPPGWLDEK
                     ERSRLAAIPQRSGKEAYAFAHWALRSVLGSSLGCPPRGVAFLRQPCPGCGGAHGRPAIR
                     DPDRGGEPPEFSMSHSGDHVAIAVAEATIGIDIECHPTPESVAGYLPFLHPREQQWLGG
                     RPADELVRDFARLWTRKEAMAKATGQGMAAVMNRLDLTGQPLGWRVRQLIAPPGYEASF
                     AVPASVHVDVIMYEDLPHPMPEAELEPV"
     aSDomain        complement(6146..6322)
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CCZ36_RS18830_ACPS.1"
                     /evalue="1.00E-07"
                     /label="CCZ36_RS18830_ACPS.1"
                     /locus_tag="CCZ36_RS18830"
                     /protein_end="191"
                     /protein_start="132"
                     /score="23.7"
                     /tool="antismash"
                     /translation="IGIDIECHPTPESVAGYLPFLHPREQQWLGGRPADELVRDFARLW
                     TRKEAMAKATGQGM"
     gene            complement(6774..7016)
                     /locus_tag="CCZ36_RS18835"
     CDS             complement(6774..7016)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489549.1"
                     /locus_tag="CCZ36_RS18835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6253 family protein"
                     /protein_id="WP_019763170.1"
                     /transl_table=11
                     /translation="MSLLPAYGYQAAVQETCDTPEYHMPLVCWHDDDNGVRGLVLYRGA
                     LRPAEQVPGFRRYLAAEGLEQYATTGPWPLLAATA"
     gene            complement(7013..7828)
                     /locus_tag="CCZ36_RS18840"
     CDS             complement(7013..7828)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763169.1"
                     /locus_tag="CCZ36_RS18840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="maleate cis-trans isomerase"
                     /protein_id="WP_069740806.1"
                     /transl_table=11
                     /translation="MTQFQAREDGWGAVARVGVVVPHADVGPESELQAMAPRDVYIHGS
                     RVHFGAMRPGGEMDPKIPHDPVRAFIDPPFIDDAVELLAASPLDSIALGFTSSAYVLGA
                     DGEQKLFERLAERTRGIPLTGTTHAATAGFRALGAERIALVNPPWFDDELSALGASYFG
                     ERGFDVVHHAPCGLPSNQKLITPEALVQWIESTVAPQKPQAVLVAGNGIRAVGTIAGLE
                     ERIGFPVLTANQVLFWHALHLAGGTEAAARISDYGALFGVRPEPGSVTG"
     gene            complement(7888..8607)
                     /locus_tag="CCZ36_RS18845"
     CDS             complement(7888..8607)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489547.1"
                     /locus_tag="CCZ36_RS18845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transglutaminase-like domain-containing protein"
                     /protein_id="WP_176734495.1"
                     /transl_table=11
                     /translation="MTDTLTDTVSAPPAPEDLDRLTAATDFLDHEHGTVRAFVDKALDG
                     IDREKAGQVELAVALYYAVRDGIHYEVYGADLSPEGLKASSIITGGKGFCLHKSVLYAA
                     ACRSVGIPARLHYSDVRNHLASDRLRSYIGGDVFFHGLVTVYLEGRWLQVTPVFNKLLC
                     RLYGMTPLEFDGRSDSLYHPFDAQGRQSMEFLTDHGDFDDVPYEFVLDNMRRKHPKFLD
                     ADGTGTVSGGSLADEAN"
     gene            complement(8623..9753)
                     /locus_tag="CCZ36_RS18850"
     CDS             complement(8623..9753)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489546.1"
                     /locus_tag="CCZ36_RS18850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_069735575.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.3e-18, bitscore:
                     66.3, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.4e-25, bitscore:
                     87.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 5.9e-32, bitscore:
                     109.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAEKDTDTYGVTAPYGDELNDDVARWDRAGEFPREKWKPLQRSG
                     LFTLPFAPEYGGAGRTLTETMSALEGLGHTSRDAGLNFSASTQIVSVGIPLQAFGSEEL
                     RSRYLPRVTSGEAITAHAITEPSHGSDVMNIRTTAVREGDEYVIDGGKMFITNAPVADL
                     FLLYVRTGKPGAFGLSTFLAERSTPGLKIGEPLETMGLRTSPISEVTLENVRLPAANRL
                     GSEGAGFLIMDYVMKREVLFSFAVNLGEMTHRLKRVVEHATTRQQFGSAIGKNQAVSHK
                     IADMRIAVETARKWLYDTGRKVEQGTDASLDVAATKIVVSEANQLTAQHAIQIFGARGY
                     LTDTGIERELRNATSGSIYSGTNEIQRNCIAALMGL"
     gene            complement(9839..10213)
                     /locus_tag="CCZ36_RS18855"
     CDS             complement(9839..10213)
                     /GO_function="GO:0033990 - ectoine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452967.1"
                     /locus_tag="CCZ36_RS18855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine synthase"
                     /protein_id="WP_069735574.1"
                     /sec_met_domain="ectoine_synt (E-value: 1.7e-24, bitscore:
                     85.3, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSLSDVPAVEWGSGTSHRLLTEADGMGFTVCETLVRKGTSSG
                     LQYLGHLEACYCIGGSGEVVTTEGVRHKIKTGTIYALDQHDAHHLLASDDEDLLLVSVF
                     SPALRGDEKHSLSEDGFSRY"
     gene            complement(10306..10566)
                     /locus_tag="CCZ36_RS18860"
     CDS             complement(10306..10566)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763164.1"
                     /locus_tag="CCZ36_RS18860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl carrier protein"
                     /protein_id="WP_069735573.1"
                     /sec_met_domain="PP-binding (E-value: 8.3e-06, bitscore:
                     24.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTASDPIRAYIVSEFLAGEDAEDLTDDFDLIESTVVNSLGLVR
                     LISWISETYRIPVDDIPLEPAAYRTLADIRRFVEQAAPASV"
     gene            complement(10563..12011)
                     /locus_tag="CCZ36_RS18865"
     CDS             complement(10563..12011)
                     /NRPS_PKS="Domain: AMP-binding (1-382). E-value: 1.1e-57.
                     Score: 187.4. Matches aSDomain:
                     nrpspksdomains_CCZ36_RS18865_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489543.1"
                     /locus_tag="CCZ36_RS18865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_079133915.1"
                     /sec_met_domain="AMP-binding (E-value: 4.3e-58, bitscore:
                     195.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQEQPDSTALVAAGERVSYAELERLTRRATADLDGAGFGSVRALC
                     VPAHKSPETIALLLAAWRQGINTLVPSPGLGAAALATLTAQAHGPLTATAVPGGGVSLV
                     REETDPAAADGFSVPDPAESLLTLTTSGSTGVPKLVPIRTHAFDRFADWATGKFGIDGT
                     TRALSFSPLNFDLALLDVWTVLEAGGTVVLADAGASGDAGYLRELTLAHEVTLVQGVPL
                     LHRLLAAEGARYPAVRTVVFTGEAVSEQGLRDAFASCPGARFHNVFGCTETNDSFIEDI
                     DPDAYVHPLPIGTPVDGTDAVLLIDGPEGSEVLQGPGTGELLVHTPFQTCGYLEQARNA
                     RAFMPDPRGGGAMFYRTGDLVHRDADGRYFLQGRTDFQVKVRGVRTNTMEVETVLGAHP
                     DVVEACVVALPCPEAGNRLHAEVVRRDGASLSSLGLRAYAAKHLPRHAVPSSVGLAGTP
                     LPKTPTGKPDRNSIKKNRLNGDTS"
     CDS_motif       complement(10836..10895)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CCZ36_RS18865_0002"
                     /evalue="3.90E-06"
                     /label="NRPS-A_a8"
                     /locus_tag="CCZ36_RS18865"
                     /protein_end="392"
                     /protein_start="372"
                     /score="19.4"
                     /tool="antismash"
                     /translation="GRTDFQVKVRGVRTNTMEVE"
     aSDomain        complement(10866..12008)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CCZ36_RS18865_AMP-binding.1"
                     /evalue="1.10E-57"
                     /label="CCZ36_RS18865_AMP-binding.1"
                     /locus_tag="CCZ36_RS18865"
                     /protein_end="382"
                     /protein_start="1"
                     /score="187.4"
                     /specificity="substrate consensus: Ala"
                     /tool="antismash"
                     /translation="QEQPDSTALVAAGERVSYAELERLTRRATADLDGAGFGSVRALCV
                     PAHKSPETIALLLAAWRQGINTLVPSPGLGAAALATLTAQAHGPLTATAVPGGGVSLVR
                     EETDPAAADGFSVPDPAESLLTLTTSGSTGVPKLVPIRTHAFDRFADWATGKFGIDGTT
                     RALSFSPLNFDLALLDVWTVLEAGGTVVLADAGASGDAGYLRELTLAHEVTLVQGVPLL
                     HRLLAAEGARYPAVRTVVFTGEAVSEQGLRDAFASCPGARFHNVFGCTETNDSFIEDID
                     PDAYVHPLPIGTPVDGTDAVLLIDGPEGSEVLQGPGTGELLVHTPFQTCGYLEQARNAR
                     AFMPDPRGGGAMFYRTGDLVHRDADGRYFLQGRTDFQVKVR"
     CDS_motif       complement(11586..11630)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CCZ36_RS18865_0001"
                     /evalue="4.90E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="CCZ36_RS18865"
                     /protein_end="142"
                     /protein_start="127"
                     /score="13.1"
                     /tool="antismash"
                     /translation="LTTSGSTGVPKLVPI"
     misc_feature    12182..12195
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.22"
                     /tool="antismash"
     misc_feature    12213..12228
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     gene            complement(12322..12765)
                     /locus_tag="CCZ36_RS18870"
     CDS             complement(12322..12765)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489542.1"
                     /locus_tag="CCZ36_RS18870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_069735571.1"
                     /transl_table=11
                     /translation="MTINQQPRAASDQTMWEAVLGLHAFVERQLAHTLQRRYGVGLSEY
                     RALETLHQAEKGECRMQELADHIGLGQSSVTRLVGRLDSAGYAYKDSCADDKRGVFAVI
                     TEEGRKRYQEARATYADVLSSALNTASTDAQLARAVQALRSAA"
     misc_feature    complement(12803..12816)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.74"
                     /tool="antismash"
     gene            complement(12888..13997)
                     /locus_tag="CCZ36_RS18875"
     CDS             complement(12888..13997)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961775.1"
                     /locus_tag="CCZ36_RS18875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_237302695.1"
                     /transl_table=11
                     /translation="MHETPEMATGRALDDLSRLLFGHLHRSDQQRWGHVYLQGLLRTHG
                     KKTVRRMAATVTGSEATSSSLHQFVNASPWEWAPVRGRLARWATRSLPVRSWTLAPTVL
                     PKRGNHSPGVHQRFLPESGRTVNCQLGLGLFLNTGQAHLPVDWQLFLPPRFTQDPAVRD
                     RAKIPATARPQSPGDHALQLVQEMTSWTDGETAPVVADLTALCDTPQLARRLQGSGHSF
                     VLAVPGQTAIGAAELPPGERPSARALLLRRGVRHPAGAGRRIISYETPVPGLRPSGEST
                     HGPGRLLAEWDADAGRPGRIWLTNITDRHPAELLELAHSPRGAESAVRRMGEDFGLLDF
                     EGRSFPGWHRHMTLVSAAYTCATLEGMNP"
     misc_feature    complement(13887..13889)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14119..14736
                     /locus_tag="CCZ36_RS18880"
     CDS             14119..14736
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763163.1"
                     /locus_tag="CCZ36_RS18880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_069735569.1"
                     /transl_table=11
                     /translation="MQERAARTRQAVLEAAAEEFAERGYEGASLQRVACRAETSIGALT
                     FHFRNKTALAEEVRLTGRARFDRSLAGLAPAADPLRELRVLIGTLARLAREDRFVRAVR
                     RLEAGPPDSAPPLAETWMPVLRAVLDRAHGARRLRPGVAPEEAEAMLAHLAEGVMAAPG
                     TPRSAAGGAVWDSVWDVVLHGLAADRGEGSVRDDREPSRAES"
     misc_feature    14356..14358
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(15007..15016)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 ttcggccagg gctacctgca ccagcccggc atcacggacg aggcgcaggc cgccgcctgg
       61 cggggcgtcg tcgaccgcgc gcacgccgcc ggcgcgcgca tcgtcctcca gctgatgcac
      121 gccggggccc tggcccaggg gaaccggttc cgggaccgga ccgccggccc gtcggcggtc
      181 cgtccgatgg gtgagcagct ggccaagtac cggggcagcg gcccgtggcc cgtaccgctg
      241 gagatgacct ccgaccagat cggcgaggct gtcgaagggt tcgccaccgc agcggtacgc
      301 gcccgtggcg ccggcttcga cggcgtcgag atccacgccg ccaacggcta cctgctcgac
      361 cagttcctca ccccgtacac caatctgcgc accgacgtgt acggcgggga gatcgagggg
      421 cgctcacggc tcctgcggga ggtgacggcg gcggtcagag ccgcggccgg acccggcttc
      481 acggtcggcg tccggctctc ccaggggaag atcaacaact tcggctggcg gtggcagggg
      541 ggcgacgccg aggcggccgc actcttcggg gcggcggtcg gggccggggc cgactatctg
      601 cacctcgccg gcagcggacg ggactggctg ccggacggcc ccacgcttcc cgggctcgcc
      661 cggaaggtca ccggagtgcc cgtgatcgcc aacggcgggc tccacgagga agcggtggca
      721 cggcgcgtcc tggacgaggg gcacgcggac gtcctggcga tcggtacggg cgcgctggcc
      781 aaccccgacc tgccgcacaa ggcggccgcg ggggctctgc cgacggcgtt cgacccgcag
      841 gtgctggagc ctctggcgac gttggacaac gcccttacgt atgcgtccgc ttgacactcg
      901 ttatatgcac atgcaagatt aaggcatcgg gtcgcgccgc tggcggagat ccacgcaaac
      961 tatatgcttg catgtgcagg caaaatggat acagggcaac tcgggagacg aactgctcat
     1021 gggtacacac gacagcgaac tgatgggctt cgcccacgaa gcgatccggc tcagccgcga
     1081 gcacgtcgcc cagggcggca ttcccttctc cggtgtcgtc gtgggcggcg gacgcatcct
     1141 gggtaccggc ttcaaccggg tccgcgagga caacgacccg accgcgcacg ccgaggtcgt
     1201 cgccctccgg caggccaccg cgcggcacgg catgcgcgcc gtggcggggg ccaccctgat
     1261 cgcctccggc gagccctgcg ccctgtgcta catggcggcg cggttcgccg gcatcggcca
     1321 catcgtgcac accgccgacc gccggaccgc cgcccggtac ggcttcgact acaccggctc
     1381 gtactccctg ttcgccgagg accccgagca ctggcccatc aaggtcacgg cgctccagct
     1441 ccccgaagcg gaagtgccgt tccaggactt cctcaccatg agccggcccc ggcactgacc
     1501 cggacccggt tccgcgacac cgccgcacgc cgtcccccac gcccgaactc ctcctcaccc
     1561 accgcccgga aggacctccc atgcactggc tctacctcgc catcgccgtc gccttcgaga
     1621 tcgctgtcgc catcgccgcc ggaaaggcgg agggcttcaa gaaccgcaag tggaccgcca
     1681 tcacgctgat cagcggtgcc ctggcgacct tcttcctcag caagtcgctg ctgaccttcg
     1741 acgtcggcgt cggctacgcc ctctggacct ccgtggcggg ggtcggcatc accatcctcg
     1801 gcgcgctctt cttcggccag cgcctgaact ggaacaaggc gatcggcatc gtcctcgtca
     1861 tcggtggcgt cgtcggcctc cagctgagcg gttccgcctg agcccgggtg caccaccccc
     1921 gaccgcacac gcggtgcctc ccgcccacca tctgacgcca ccccagagag gatccacctc
     1981 ccatgtccaa cgaagccaag acctccacca acgcctggct ctcgctcctg ctcgccggag
     2041 tcttcgagat cggctacgcg ctggccgtcg gcggcagcga agggttcacc gtcctgacct
     2101 ggtccctggt cgccgtggtg ttcttcctgc tgacgctcta cgcactgagc ctcgccctcc
     2161 gcacgatcga ggtcagcatc ggatacgccg tctgggcggg catcggcgcg gtcggcgccg
     2221 ccgtcctggg ccccgtcttc ttcgacgaga ccctgaccct ggccaagggc atctggctgt
     2281 cggtcatcat cgtcggtgtc atctggctga agctcgccga ccgtacgaag cccgagacgg
     2341 ccgccccggc cccggcggcc cagcaggtcg cggaccggcc cggcgcgctc caggtctgac
     2401 gccccgcgaa cgtacgcccc cggcggctgc ctcccatcag gaatgggcgg cagccgccgg
     2461 gggcgtgccg tcgtaccgcg cgccgctgtc ctcacgaggc ggtccgggcc gtcccgggcg
     2521 tgggctccgt cgtcatttcg ccgtccgtcc accgtccacc gcgagggcgg tcccggtggt
     2581 gaaggaggcg gcgtccgagc agagccaggc ggcggcgcgg gcgatctcga ccggatcggc
     2641 cagccgccgc tggatgccct gcgagccgaa acccgcgtcc acggtgaggc cggtggagcg
     2701 gaaggagtcc atcatctccg tgtcggtgcc gcccaccacg agggcgttga cccggatgcc
     2761 gtgctcgccg tactcggcgg ccgccgccct ggtgaggccg atgaccgcgt gcttcgcggc
     2821 cacatagggc gccgacgcgg cggtggcccg tacgcccgcg acgctggacg tgttgacgac
     2881 cgctccggcg ccggcctcca gcatggcggg gatctcggcg cgcaggcagt tccacacacc
     2941 gcgcagattg acgtccaggg tgcggtcgaa gacgtcgtcg gggagttcgt gcaggaccgt
     3001 tccggcgctg gcgtacccgg cgttgttgaa cgcgcagtcg aggctgccga accggtcgac
     3061 cgccgtggcg acggcccgtt ccatgtccgc ggggcgggtg acgtcacccg gtacggccac
     3121 ggcccggccg ccgtccttcc ggatgcgctc ggcgacctcc tccacctggg cggcccggcg
     3181 ggcgacgagc acgacggcgg ctccctcggc ggcgaagtgg cggccggccg cggcgcctat
     3241 gccgctggag gcgccggtga tcagcgccac cttgccggac agcagcggtc cgcccggcgt
     3301 cacgcctgtc tctcccggcc ggccgccacg agggcggggc tccagaacgt gcccgtgctc
     3361 atctcctggt cgatccggtg cagcagaccg tcgtcgagcg cgtccaggcg gtcgaccatg
     3421 tggcgtacgc ccgcctcccg catgagggtg cgctggtggc tgtgggcgaa ggcggagggg
     3481 tgaccgacga aggcggtgcc caacgcgcgg gcctcctcgg cgacccgggc gacgtcgtcg
     3541 acgaagaggg cctgggcggg acggagcccg aagacgtcct cggtgatctc ccggagaccg
     3601 gggcggatgt cgttggtgct gacgtagccg gggccgtcga acaggtgggc gtagcggccc
     3661 agatggcggt cgaagtgctc cttgcccagg cccccgtagc agaccgtgcg caggcccgcg
     3721 ctccgcagcc ggaggagcag gcggtgcgtg cccggggtga tcgtgaccgg gtgccggccg
     3781 acgtgggcgg cgcgctcctc gaagtaggcg gcgagcgccg cctcgcccgt catgccgccg
     3841 cccacggcgg ctgcgagccg ttgcccggct atgtgctgcg actgggagaa gaccgatcgc
     3901 tccagcgcgg ccgagtaggt cccgccccgg ctgacgacga actggtggat caccgggctg
     3961 aaggtgtcgt tgagcaggac accgtcgatg ttcagggcgg ccaggcgtaa ggaaagcatg
     4021 gggctccttg aggctcgttc gaggcgggag gaacggtcgg cgggctgagc ggtcagggcg
     4081 tcatcgcggc gccccgggca ggggtcgcgt cggcgcgcgt gatcacggac gggaccgcga
     4141 tgcccggaag gatgaggttc cacatctgct gcgtgcgctc gggaaggtcc tggcggccgc
     4201 tgacgacgtt ggagtacatc tgcatcccgg tacaggccgc gaccacgaac tccgcgacca
     4261 cgaccgggtc gacgccgggc tggagctcgc cgtcgttctg ggcgtcctgg aggcacccgg
     4321 tcatgatcgc gcggaacttc tcgtacgggt cggcgttggc cggaccgccc acggaggttt
     4381 gctcgttggt cagccggacg ccggcccgca gcagtggatc gcgctggagc tgccacgacc
     4441 agacgagcgt gatgtcgatg agccgttgca ggcccccggc ggccaccagc gggaccaggg
     4501 tctccggctg gctgttcatc accgccttgg cgaggtcctc cttggagccg aagtggaagt
     4561 agagcgctcc ggccgtcaca ccggcgcgct tgaggatgcg cgtgatgctt gcacccgcgt
     4621 agccgaactc gtcgaacacc tctgctgccg cgtggaggag agcgcggcgg gtctgctccg
     4681 ctcgctcctg tttcggttgt gccatgccct gtcaccttcc caaaaagaat gacccttatg
     4741 ttatccggcc cgaccggcgc cagggcaagt cccgtttgtt ccagttaagt tgcttatgca
     4801 tactcctgga cgccaaaaaa agtcaggctc gcgttgctct tgacccagca aaacaaaaga
     4861 aacattattt ttgagtcggc acggggggtg ctcatgtcgc tcctctgcgc agtcatccgt
     4921 gagcaacgac cgatcgtggg gggtccacgt tgtctgtttc cgtactgagc cgtggcgtac
     4981 agccggtcca gcagtctcag gtgcaccagt ggcaggtgca caagctccgg ggggaggaag
     5041 tactgctcag gacgtggacc gaggaagact ccggacgctt cgtgatcacg gcccgctggc
     5101 cgaaggggca cgcgttctac cagccgtcgc agggcgcgta cgatccgctg ctgctcgcgg
     5161 agaccgtgcg ccagacagtg ccgctgctct cccacgccgt gcacggcgtt cctcgggagc
     5221 acaagcaggc gtgggagtgc ttagacttcg cggtcgagcc gctggccgcc ctggtcacca
     5281 ccgccgagga cgaggtgcgt ctggtggtgt cctgctcgga cgtggtccgg cgcggcaaca
     5341 ggttcgcggg catgacgatg gacatcgacg tccacctcgg caagcgactc atggggatcg
     5401 cgcacacccg cttcaacgac cagcccgcgg ccgtctaccg gagaatgcgc aggggctacg
     5461 cggacatcga cgccgcactg gagaaccgcc tcccggcggg cccgccggtg gagccgcacc
     5521 gggtgggccg cggttccccg gccgacgtgg tcctctcgcc ggccctgggg ggcgagagac
     5581 ccggccggtg gctgctgcgg gtggacaccg cccacccggt gctcttcgac cacccggtcg
     5641 accacgcgcc cgggatgctc ctgctggagg ccgcccggca ggcggcgcgc gccgtcggcg
     5701 gggccaccgc agcggtcatc ggaatgcgga cgaacttcgt ccggtacgtc gaactcgacg
     5761 ctccggccgt ggtcgtggcc ggttccccgg cacccgtcgg ccccggcagg cgccgggtgc
     5821 ccgtctcgat cgagcaggac ggcgtccagg tcttcacctc cgaggtgacc atcgccggat
     5881 gagggcctgc tccccggggc ccacgacgtg acgcggcggg cggtccgtac ctcctcgctc
     5941 ggaggtacgg accgcccgcc accggtcaga ccggctccag ctccgcctcc ggcatcgggt
     6001 gcgggaggtc ctcgtacatg atgacgtcca cgtgcaccga cgccggaacg gcgaagctgg
     6061 cctcgtaccc gggtggggcg atcagctgcc tcacccgcca gccgagcggc tgtccggtga
     6121 ggtcgagccg gttcatgacc gccgccatgc cctggccggt cgccttggcc atggcctcct
     6181 tacgggtcca caaccgggcg aagtcgcgga ccagttcatc ggccggacgg ccgcccagcc
     6241 actgctgttc cctcgggtgg agaaagggca gatagcccgc caccgactcc ggggtcggat
     6301 ggcactcgat gtcgatgccg atggtggcct cggccaccgc gatggcgacg tggtccccgc
     6361 tgtgcgacat cgagaactcc gggggttcgc cgccccggtc cggatcacgg atggccggcc
     6421 tgccgtgcgc cccgccgcag ccgggacacg gctgccgcag gaaggcgacg ccccggggcg
     6481 ggcagccgag tgaggagccg aggacgctgc gcagcgccca gtgggcgaag gcgtaggcct
     6541 ccttgccgga gcgctgcggt atcgcggcca gccggctccg ttccttctcg tcgagccagc
     6601 cgggcggtga cccgtcgggc ggcagccgct gcccggccgg ggcccggacg atccagacgc
     6661 ccacctggtc gcggacctcc cccgggggcg cgtcggacca cttgaggtcg tgtgtcatgt
     6721 cgatacggct cctgatgtgg cggggacccg gccggccccc gccacgggtc ggatcaggcg
     6781 gttgctgcga gcagcggcca cgggccggtc gtggcgtact gttccagacc ctcggcggcg
     6841 agatagcgcc ggaaccccgg cacctgctcc gccgggcgca gtgccccgcg gtacagcacc
     6901 aggccgcgca cgccgttgtc gtcgtcgtgc cagcacacca ggggcatgtg gtactcgggg
     6961 gtgtcgcagg tctcctgcac ggcggcctgg tagccgtacg cgggcagcag gctcatccgg
     7021 tcacgctccc gggttccggg cggacgccga acagggcgcc gtagtcgctg atccgcgcgg
     7081 ccgcctcggt accgccggcg aggtgcagcg cgtgccagaa gagcacctgg ttggcggtca
     7141 ggacggggaa gccgatccgc tcctccaggc ccgcgatggt gcccacggcg cggatgccgt
     7201 tgccggcgac caggaccgcc tgcggcttct gcggggcgac ggtggactcg atccactgca
     7261 ccagggcctc cggggtgatc agcttctggt tgctggggag accgcagggg gcgtggtgga
     7321 cgacgtcgaa gccgcgctcg ccgaagtagg aggcgcccag ggcggacagc tcgtcgtcga
     7381 accacggcgg gttgaccagc gcgatccgct cggcccccag ggcccggaag ccggccgtgg
     7441 ccgcgtgggt ggtgccggtg agcgggatgc cccgggtccg ctcggcgagc cgctcgaaga
     7501 gcttctgctc gccgtcggcg cccaggacgt aggcggagct ggtgaacccc agggcgatgg
     7561 agtccagcgg ggaggcggcg agcagttcga ccgcgtcgtc gatgaagggc gggtcgatga
     7621 aggcgcgcac cgggtcgtgc gggatcttgg ggtccatctc gccaccgggc cgcatcgccc
     7681 cgaagtggac gcgggagccg tggatgtaga catcgcgcgg ggccatggcc tggagctcgg
     7741 actccggccc gacgtccgcg tgcggaacga cgacaccgac gcgggcgacg gcgccccagc
     7801 cgtcctctcg ggcctggaac tgcgtcatgg ggtgcttctc ctcttcttct gccgttcttc
     7861 tctgcggggg aggggggagg ggagggctca gttcgcctcg tcggccagcg aaccgccgct
     7921 gaccgtgccg gtgccgtccg cgtcgaggaa cttcgggtgc ttgcggcgca tgttgtccag
     7981 gacgaactcg tacggcacgt cgtcgaagtc gccgtgatcg gtgaggaact ccatgctctg
     8041 ccgcccctgg gcgtcgaagg ggtggtagag gctgtccgag cgtccgtcga actccagcgg
     8101 ggtcatgccg tacagccggc acaggagctt gttgaagacc ggggtcacct gaagccagcg
     8161 gccttcgaga tacacggtga ccaggccgtg gaagaagacg tcgccgccta tgtaggagcg
     8221 cagccggtcg gaggcgaggt ggttgcggac gtcgctgtag tgcagccggg ccgggatgcc
     8281 gacggagcgg caggcggcgg cgtagagcac ggacttgtgc aggcagaagc ccttgccgcc
     8341 ggtgatgatg ctggacgcct tcagcccctc gggcgagagg tcggcgccgt agacctcgta
     8401 gtggatgccg tcgcgcaccg cgtagtagag ggcgacggcg agttcgacct ggccggcctt
     8461 ctcgcggtcg atcccgtcca gggccttgtc gacgaaggcg cgcacggtcc cgtgctcgtg
     8521 gtcgaggaag tcggtggccg cggtgaggcg gtccaggtcc tcgggggccg ggggtgcgga
     8581 gacggtgtcg gtcagggtgt cggtcatggc ggatacctct cgtcacaggc ccatcagggc
     8641 ggcgatgcag ttgcgctgga tctcgttggt gccggagtag atggagccgg aggtggcgtt
     8701 gcgcagctcg cgctcgatgc cggtgtcggt cagatagccg cgggcgccga agatctggat
     8761 ggcgtgctgg gcggtgagct ggttggcctc gctgaccacg atcttggtgg cggccacgtc
     8821 cagcgaggcg tccgtgccct gctcgacctt gcgcccggtg tcgtacagcc acttccgggc
     8881 cgtctccacg gcgatcctca tgtccgcgat cttgtgggag accgcctggt tcttgccgat
     8941 ggcgctgccg aactgctggc gcgtggtggc gtgttcgacg acgcgcttga gacggtgggt
     9001 catctctccg aggttgacgg cgaaggagaa gaggacctcc cgcttcatca cgtagtccat
     9061 gatcaggaag ccggctccct cgctgcccag ccggttggcg gcgggcagcc ggacgttctc
     9121 cagcgtgacc tcgctgatgg gtgaggtgcg cagccccatc gtctccagcg gctcgccgat
     9181 cttcaggccg ggcgtggagc gctcggcgag gaaggtgctc agtccgaagg cgcccggctt
     9241 gccggtacgg acgtacagca ggaagaggtc ggcgacgggg gcgttggtga tgaacatctt
     9301 gccgccgtcg atcacgtact cgtcgccctc gcggaccgcg gtggtccgga tgttcatgac
     9361 gtcggagccg tggctcggct cggtgatcgc gtgcgccgtg atggcctcgc cggaggtgac
     9421 ccgcggcagg taccgcgagc gcagctcctc ggagccgaac gcctggagcg ggatgccgac
     9481 gctgacgatc tgggtggacg ccgagaagtt gaggccggcg tcccggctgg tgtggccgag
     9541 gccctccagc gcggacatgg tctcggtgag cgtccggccg gcgccgccgt actccggggc
     9601 gaaggggagg gtgaagaggc ccgaacgctg gagcggcttc cacttctcgc gggggaactc
     9661 gccggcccgg tcccagcggg cgacgtcgtc gttcagctcg tcgccgtacg gcgctgtgac
     9721 gccgtaggtg tctgtgtcct tctctgctgc catgagggct ctgccttgcc tttcgccggt
     9781 cgcggggtga gccgggtgcg gggccgcgcc gtcgcggccc cgcacccggc ggcggtgatc
     9841 agtagcggga gaagccgtcc tcggagagcg agtgcttctc gtcgccccgc agcgccgggc
     9901 tgaagacgga gacgaggagc aggtcctcgt cgtcggaggc gagcaggtgg tgggcgtcgt
     9961 gctggtccag ggcgtagatg gtgccggtct tgatcttgtg gcggacgcct tcggtggtga
    10021 cgacctcgcc cgagccgcct atgcagtagc aggcctccag gtgaccgagg tactgaagcc
    10081 cgctggaggt gcccttgcgg accagcgtct cgcagacggt gaagcccata ccgtcggcct
    10141 cggtgagcag gcggtggctg gtgccgctgc cccactcgac cgcggggacg tcggagagag
    10201 aacggacgat catggaagta ctcctgtcat cgttgtgttc tggacgtgtg ctggtgcgct
    10261 ggagcgtgtg gggggggcgg gcggtgcggg ggtggagctg tggggtcaga cggaggccgg
    10321 ggcggcctgc tcgacgaagc ggcggatgtc cgcgagcgtg cggtaggcgg ccggctccag
    10381 ggggatgtcg tcgacgggga tgcggtaggt ctcggatatc caggagatga ggcggaccag
    10441 gccgaggctg ttgacgacgg tgctctcgat gaggtcgaag tcgtcggtca ggtcctcggc
    10501 gtcctcgccg gcgaggaact cgctgacgat gtaggcgcgg atcgggtcgc tggcggtggt
    10561 gctcatgagg tgtctccgtt cagtcggttc ttcttgatcg agttacggtc gggcttgccg
    10621 gtcggggtct tcggcagcgg tgtgccggcg agcccgaccg agctgggcac ggcgtgccgc
    10681 ggcaggtgct tcgccgcgta cgcccgcagt cccagcgagc tgagggaggc cccgtcccgg
    10741 cgcaccactt cggcgtgcag ccggttgccg gcctcggggc agggcagggc gacgacacag
    10801 gcctcgacga cgtccgggtg ggcgccgagg acggtctcga cctccatggt gttggtgcgc
    10861 acgccgcgca ccttgacctg gaagtcggtg cgtccctgga ggaagtagcg gccgtcggcg
    10921 tcgcggtgga cgaggtcgcc ggtgcggtag aacatggcgc cgccgccgcg cgggtcgggc
    10981 atgaaggcgc gggcgttacg ggcctgttcg aggtagccgc aggtctggaa gggggtgtgc
    11041 accagcagtt cgccggtgcc cggcccctgg aggacctcgc tgccctcggg cccgtcgatc
    11101 agcaggaccg cgtcggtgcc gtcgaccggg gtgccgatgg gcagcggatg gacgtacgcg
    11161 tcggggtcga tgtcctcgat gaagctgtcg ttggtctcgg tgcagccgaa gacgttgtgg
    11221 aagcgggcgc ccgggcagga ggcgaacgcg tcccgcagcc cctgctcgga gacggcctcc
    11281 ccggtgaaga cgaccgtacg gaccgccggg tagcgagccc cttccgcggc cagcagccgg
    11341 tggaggaggg gcaccccctg gacgagggtc acctcgtggg cgagggtcag ttcccgcaga
    11401 tagccggcgt ccccgctggc cccggcgtcg gccagcacga ccgtgccgcc ggcctccagg
    11461 accgtccaga cgtcgaggag cgccaggtcg aagttgagag gcgagaagct cagcgcccgg
    11521 gtcgtgccgt cgatcccgaa cttcccggtg gcccagtcgg cgaaccggtc gaaggcatgg
    11581 gtgcggatcg ggacgagctt gggtacgccg gtggacccgg aggtggtgag ggtcagcagg
    11641 gactcggcgg ggtcggggac gctgaagccg tccgccgccg cggggtccgt ctcctcccgc
    11701 accaggctca caccgccgcc ggggaccgcc gtggccgtca gcgggccgtg ggcctgggcg
    11761 gtgagcgtgg ccagggcggc ggcgcccaga ccgggggagg ggaccagggt gttgatcccc
    11821 tgacgccagg ccgccagcag cagggcgatg gtctccggtg acttgtgggc cgggacgcac
    11881 agggcgcgga cggatccgaa gccggcgccg tccaggtcgg cggtggcgcg gcgggtcagc
    11941 cgctccagct ccgcgtagct gacccgctcg ccggcggcga cgagtgcggt gctgtcgggc
    12001 tgttcctgca catgtctgct gaaggcctgt aacaggcgag gcgatggcaa cggtccccct
    12061 cggtggatgg gcgatctcac ggcgggatcc ggccgtgcga gtgagccgcg cggtccgact
    12121 gcgagatccg gctgcgaggc cgcgagatct ggctacgaga gagaacctac gcggttctat
    12181 ttgcatggtc aagcaaatag attgggcgtt cgtgtgatcc aggccacacc cctgtcgcct
    12241 tcgaaggaag cccgaacatg caaaggacgg cgggaggcgg ccgggttgcc ccggccgcct
    12301 cccgccgtcc tcgtggtcgt gtcaggcggc gctgcgcagc gcctgcaccg cccgggcgag
    12361 ctgggcgtcg gtgctcgcgg tgttgagggc cgagctgagg acgtcggcgt acgtggcgcg
    12421 ggcttcctgg tagcgcttgc ggccttcttc ggtgatgacg gcgaagacgc cgcgcttgtc
    12481 gtcggcgcag ctgtccttgt aggcgtagcc ggcgctgtcc agccgtccca ccaggcgtgt
    12541 gaccgaactc tggcccaggc cgatgtggtc cgccagttcc tgcatgcggc actcgccctt
    12601 ctcggcctgg tggagggtct ccagggcccg gtactcggac aggccgaccc cgtagcggcg
    12661 ctggagggtg tgtgcgagct ggcgttccac gaaggcgtgc agaccgagaa cggcctccca
    12721 catggtctga tcggaggcgg cgcgtggctg ctggttgatc gtcatggaac agctcccctt
    12781 ctcgactgcg ataccaacaa gatacatgcc catgcaatca tttggggagg gctggtgcct
    12841 gcgggagcgg gtgctggccg atatttactt gtatgcgcaa tgaagagtca ggggttcatg
    12901 ccttcgagag tggcacacgt gtaggcggcc gagacgagtg tcatgtgccg gtgccagccg
    12961 gggaaggagc ggccctcgaa gtcgagcagg ccgaagtcct cgcccatgcg ccggaccgcg
    13021 gactccgcgc cccggggcga gtgggccagc tccagcagtt cggccggatg gcggtcggtg
    13081 atgttggtca gccagatccg gcccgggcgc cccgcgtccg cgtcccactc ggccagcagc
    13141 cggccgggcc cgtgggtgct ctcgccgctc gggcggagcc cgggcacggg ggtctcgtac
    13201 gagatgatcc ggcggcccgc ccccgccggg tgccgcaccc cgcggcgcag cagcagcgcc
    13261 cgcgccgacg gccgctcacc cggcggcagt tcggctgcgc cgatggcggt ctggcccggg
    13321 acggcgagca cgaaggagtg cccgctgccc tggagtcgcc gcgccagctg cggggtgtcg
    13381 cacagggctg tcaggtcggc caccacgggc gcggtctccc cgtccgtcca ggacgtcatc
    13441 tcctggacca gctgcagggc gtggtccccc ggtgactgcg gccgggccgt cgccgggatc
    13501 ttcgcccggt cccgtacggc tgggtcctgg gtgaagcgcg gcggcaggaa gagctgccag
    13561 tcgaccggga ggtgtgcctg cccggtgttc aggaagaggc ccagccccag ctggcagttg
    13621 acggtgcgcc ccgactccgg caggaagcgc tggtgcacgc cgggcgagtg gttcccccgc
    13681 ttgggcagca ccgtcggcgc cagggtccag ctccgcaccg gcagcgaccg ggtggcccag
    13741 cgggccagcc ggccgcggac cggggcccac tcccaggggc tggcgttcac gaactggtgc
    13801 agcgacgacg acgtcgcctc ggagccggtc acggtggcgg ccatgcgccg cacggtcttc
    13861 ttgccgtgcg tacgcagcag gccctgtaag tacacatgcc cccaacgctg ctggtcggag
    13921 cggtgcaagt ggccgaagag gaggcgggac aggtcgtcca gcgctcggcc cgtcgccatc
    13981 tcgggcgttt cgtgcatcgt cgtcactgca agtccctccc aggtgagcgt cgctgagcag
    14041 actaacaaac atagagaatg ttcgttatat ttctgaggga gaagagtggc gacttaccga
    14101 ggttcaagga gaaggcgcat gcaggaacgg gcggccagga cccgacaggc cgtgctggag
    14161 gcggcggccg aggagttcgc cgagcggggt tacgaaggcg cctcactcca gcgggtggcc
    14221 tgtcgggccg agacctcgat cggcgctctg accttccact tcaggaacaa gaccgccctg
    14281 gccgaggagg tgcggctcac cggacgtgcg cgcttcgacc gctccctggc gggactcgcc
    14341 cccgccgccg acccgttacg ggagctgcgg gtcctgatcg gcacgctggc ccggctggcg
    14401 cgcgaggacc gcttcgtccg cgccgtacgc cgcctggaag ccggtccgcc ggacagcgct
    14461 ccgccgttgg ccgagacctg gatgcccgtc ctccgtgccg tgctcgaccg ggcccacggt
    14521 gcccggcggc tccgcccggg cgtcgcgccc gaggaggcgg aggccatgct ggcgcacctg
    14581 gcggaggggg tgatggccgc ccccggcacg ccccggagcg cggcgggggg cgcggtctgg
    14641 gactccgtct gggacgtcgt cctgcacggc ctcgccgcgg accggggcga ggggtccgtc
    14701 cgcgacgacc gggagccttc gcgggcggag agctgacggg ccccggcccg acggcggccg
    14761 gggcccgtct cgcaccgctc ccgccggcgg gccggcggat tcctcagccc gcccgcagcg
    14821 accggtccac cgcgtcggcc acctcgtcca gcagccgggc gcccgggccc gccgtcagcc
    14881 ggccgcggac ccaggcggcg ccggtccggg cccggggcca ggcctggtag gtgaccgacc
    14941 cggggccctg gtggccgaag gcgccggagc ggacggccgg gtgcagcccg tcgtcgagga
    15001 gctggaggcc gccttcgccg taggcgctga ccccgccgag cagcgggtcc aggccctcgg
    15061 cccagaagct ccgcgcctgg tcgagcgtgc gccgcgacag cagcagcggc tcctcgcccg
    15121 gagcccgtac ggcgtcggcg gccaggacgc cctggagccg ggcgaggccg cgggccgacg
    15181 cgtacgcccc cagcgagggg atgaccgcgt agc
//
