LOCUS       NZ_CP021707            23057 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces sp. S063 chromosome, complete genome.
ACCESSION   NZ_CP021707
VERSION     NZ_CP021707.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S063
  ORGANISM  Streptomyces sp. S063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Complete genome sequence of Streptomyces sp. S063, a producer of
            anti-complement compounds and various secondary metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAY-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:19:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,905
            CDSs (total)                      :: 6,817
            Genes (coding)                    :: 6,244
            CDSs (with protein)               :: 6,244
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 574
            CDSs (without protein)            :: 573
            Pseudo Genes (ambiguous residues) :: 0 of 574
            Pseudo Genes (frameshifted)       :: 432 of 574
            Pseudo Genes (incomplete)         :: 192 of 574
            Pseudo Genes (internal stop)      :: 13 of 574
            Pseudo Genes (multiple problems)  :: 61 of 574
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:16:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3948195
            Orig. end                         :: 3971252
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021707.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Xinqing Zhao, Life Science
            and Biotechnology, Shanghai Jiaotong University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23057
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="12"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23057
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23057
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13057](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13057)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(84..98)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 20.98"
                     /tool="antismash"
     gene            484..1620
                     /locus_tag="CCZ36_RS18150"
     CDS             484..1620
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126209.1"
                     /locus_tag="CCZ36_RS18150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="histidine kinase"
                     /protein_id="WP_237302689.1"
                     /transl_table=11
                     /translation="MSLTCRTSLTSRRTRAVGRAAVPVGIAVGDGLLVNGFGTGPGLWV
                     ALAAAGALVLRRRWPEVVLLVGLPGMYVGHLAFAPLIALYCLADRRRNVAVGAVGAVAV
                     ALAQFLPYPVTDLPELAVDRETLIMAMDSCVLAVGALVLGRTARVRRERQRELAEGRER
                     EHRLLAERTLSTERAWLAREMHDVVAHQVSLISLQVGALQVGEPDAATVRSTAGTVREL
                     SVKTLTELQHMVGVLRAAGGPAPGLDPQPRLTDLPALVRDCGLRVTLAAPDTPGHWSQA
                     VERAAYRTVQEALTNVTKHAPGAEVDIRVQPLDGGLRVDVRNTADDGSAAPLGLPAGGH
                     GLIGLRERALLLGGTFEAGPEPGGGFRIQAVFPSRQTF"
     misc_feature    complement(1718..1732)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.59"
                     /tool="antismash"
     misc_feature    1719..1733
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.36"
                     /tool="antismash"
     gene            1883..2566
                     /locus_tag="CCZ36_RS18155"
     CDS             1883..2566
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="CCZ36_RS18155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_107474809.1"
                     /transl_table=11
                     /translation="MADDCIAVGLMVARLSLRRRLTRLFAHRGWNAVACEGAGGLLSSG
                     DRSGVSSGVSPGLPSGVSSDVLVVDIDRLDEIRGTTPVVALTYGSEIDRLGAVKADVRA
                     VVDRDDLDEAFLEAVQEVAAGHGWISPTLVRPLLRGQPSAPAGAVRPTVVPAQVHRPGR
                     PHDPALTAREYEVVSLVSKGMNNSEIAGALYIAESTVKFHMSNILQKTGFRNRGQLVAR
                     MPVAG"
     gene            2610..2795
                     /locus_tag="CCZ36_RS18160"
     CDS             2610..2795
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126210.1"
                     /locus_tag="CCZ36_RS18160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_234427873.1"
                     /transl_table=11
                     /translation="MGKKKEALRWAPVVILLVFALIAPLFGDSPTGVVIPLLLAVMLAG
                     VNVTVQKKERSAGGTE"
     gene            complement(2898..3782)
                     /locus_tag="CCZ36_RS18165"
     CDS             complement(2898..3782)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="CCZ36_RS18165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_107474808.1"
                     /transl_table=11
                     /translation="MSTGTGTSTAAVARTGRGASPATDSAPGSGAVSTADLLRSEVLKL
                     TTTRLWWILLLAVVACGAGFTALIVFGGLNAPRSPLSFGAAGDAVPAYNLPVALAYVFP
                     LAIGVITVTQEYHARTISATLLAEPRRARVYGAKLVVGLGTAFVYGAVAVLSGALVAAA
                     LLAGHGKPTYLTDGTVLGALGGSVLVMTLWGAIGVGVGALVRNQVAAIVGILLVTQFVE
                     PTLRILASSLGNAELGNLLPGGAGDLAGGGTIMTAAAEADGGSQGLGFLVLFLYAVVIG
                     AVGATRFTRYEAS"
     gene            complement(3779..4555)
                     /locus_tag="CCZ36_RS18170"
     CDS             complement(3779..4555)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980797.1"
                     /locus_tag="CCZ36_RS18170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_079149573.1"
                     /transl_table=11
                     /translation="MAQDAHTTQDHTQNRQDARQQVITVRDLQKEFRGTRAVDGVSFDV
                     RPGRVTGFLGPNGAGKTTTLRMILGLIRPTGGSALLWGSPYAGLAAPTRRIGVGLDGGA
                     FVGRRTGRGHLRCYAPAAGCGPERVDRLLADVGLSGAADRPVAGYSTGMKQRLSLASAL
                     LGDPELLILDEPANGLDPEGMLWLREFLRDFAASGRTVLLSSHLLGEMEQTVDDVLLMH
                     HGRLLISGPLDGLLEPGERLESAFLRLTRAGNGVRA"
     gene            complement(4575..6728)
                     /locus_tag="CCZ36_RS18175"
     CDS             complement(4575..6728)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="CCZ36_RS18175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_128818117.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.1e-32, bitscore:
                     111.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRVRRVREVQQFAQAECGLCCIAMILSAYGSRDSVAGLRRDHEV
                     GRDGLTIKQIAAILRGRGFEVRAFRAGVERLDQLELPLIAYWDDSHVVVVEEIDEHRVT
                     VVDPGGGRRRYSAEEFAEHYSGLALEAVPTPDHRPERHREPSVWREFLRSLTGARKPLL
                     QAFLMSLVLYSFTIFMPIATQYAVNDYAGYLERAPIALVLVAFLAPMTVFFLLSLLRTV
                     ALASVIRSLGEAMMGKTFRRLLELPYKYFANRSQGELFYRLSSITSVRDMISSQLSVVL
                     LDLGSLIAIFSYMFYRSFTLGATAFAVFLTMLAVAVGTYRPIRRITEREISETTKSSSL
                     QMEALSSIETLKVSGMTGTFFRDWQRVYAAGMEQTRRRIVLQGVATSGYAVFQVFGPLL
                     VLAVGLWLVLNGSLDLGSAVAAQTLTATSLGMVMSLSGAFTQLITANAQVARVGDILHQ
                     PEDPGAFGDRPVAVRGAVRLRNVGFSYPGSRTPALADVTFDIRPGERVAIVGSSGSGKS
                     TLGKLLMGLYPIRSGDVLYDGVSIGEIDADTFYRNAAYVPQDIVLSNRSIADNIRFGVP
                     DATMEAVVDAARQAHVHDDIAAMPLGYHTPVREMGGSLSGGQRQRIALARALARRPRVL
                     VLDEATSALDTVTESRIAAALDRLECTRIIIAHRLSTIVNADLVVVLEHGRVVQTGRHE
                     ELITEPGPYRDLVRSQVDLNTVR"
     misc_feature    complement(6725..6738)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     gene            complement(6740..7210)
                     /locus_tag="CCZ36_RS18180"
     CDS             complement(6740..7210)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="CCZ36_RS18180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_128818118.1"
                     /sec_met_domain="LANC_like (E-value: 7.9e-12, bitscore:
                     43.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGRGPARPGDGGGNGGWCKGYAGIAYAHAALLTALGEPAGRIAE
                     AVAPEIARVTEPAGAGRSTAIAPDLSLCHGLAGRIAVLCHLADLLARPDLRDAAAALHT
                     AFLDRYGNGGWSCGIGTEPLLPSYFLGLSGWFAAQAMLDHPGTGLPRCLGGR"
     gene            7324..7932
                     /locus_tag="CCZ36_RS18185"
     CDS             7324..7932
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CCZ36_RS18185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_128818119.1"
                     /transl_table=11
                     /translation="MGQAEFIPLGVLGRVAVHRDEAAQQPFGPGPGDLGRAVLGVGGEV
                     DEVAAVAVEVVEVGGGEAVDVERALARVEPDVLLARPEPGVGRGQPPDLPVGHQVGERA
                     GERRHRQRRPVEHGRPGAHGRGADPLRVHTHGGHAGAGRALREVQQQPAAVVQRRVDAA
                     EAEPVAPEAGRQPGRGVRPADDEVAEQGVPAGRVGEVDG"
     misc_feature    complement(7331..7345)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.42"
                     /tool="antismash"
     CDS             8417..8650
                     /gene="allorf_3956612_3956845"
                     /locus_tag="allorf_3956612_3956845"
                     /protein_id="allorf_3956612_3956845"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRASRNPATSSSVQRRGSSGSPATVAMLEPCSTTTWLRSKRMSSV
                     PASTTRYDWRCSEAPGRTQPIPEMSTSSLDAA"
     CDS_motif       8417..8560
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MRASRNPATSSSVQRRGSSGSPATVAMLEPCSTTTWLRSKRMSSVPAS"
                     /locus_tag="allorf_3956612_3956845_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8561..8650
                     /prepeptide="core"
                     /locus_tag="allorf_3956612_3956845_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.90"
                     /molecular_weight="3083.3"
                     /monoisotopic_mass="3081.5"
                     /core_sequence="TTRYDWRCSEAPGRTQPIPEMSTSSLDAA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRASRNPATSSSVQRRGSSGSPATVAMLEPCSTTTWLRSKR
                     MSSVPAS"
                     /leader_location="[8416:8560](+)"
                     /alternative_weights="3101.4"
                     /alternative_weights="3119.4"
                     /alternative_weights="3137.4"
                     /alternative_weights="3155.4"
                     /alternative_weights="3173.4"
                     /alternative_weights="3191.5"
                     /alternative_weights="3209.5"
     gene            8815..9546
                     /locus_tag="CCZ36_RS35795"
     CDS             8815..9546
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CCZ36_RS35795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_237302690.1"
                     /transl_table=11
                     /translation="MVQVGGAQHRQERGGPAETAEVAGAVLRRTVEVGVDHELLPDVRG
                     PNEGAGVQRTEERAVRVEERTQRGQELLAVVLLRLVHGPRAVVPDHQADGPPAPVGVAE
                     ARGDRDDPAGPAEERVQLRPVRDGGVQHVGHRACGTGGGEAQQPVQLGEAVEHRLAAGG
                     PGEAGVERLVPGVLGAEGGDEGADAGLDAEAHERAERGLGDPGEVGCVLHRVRAREGGG
                     EPGDALGAVPQIRRVERAEDV"
     gene            complement(9702..9902)
                     /locus_tag="CCZ36_RS18195"
     CDS             complement(9702..9902)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038161.1"
                     /locus_tag="CCZ36_RS18195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class II lanthipeptide, LchA2/BrtA2 family"
                     /protein_id="WP_065486453.1"
                     /transl_table=11
                     /translation="MGDIAMNDATGYVSADELVELADAPDSLAAGITPTIVPATAVTTV
                     IVGASAAMQGGCPTSGCTKRC"
     CDS_motif       complement(9831..9902)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGDIAMNDATGYVSADELVELADA"
                     /locus_tag="CCZ36_RS18195_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9702..9830)
                     /prepeptide="core"
                     /locus_tag="CCZ36_RS18195_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.80"
                     /molecular_weight="3795.4"
                     /monoisotopic_mass="3793.0"
                     /core_sequence="PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGDIAMNDATGYVSADELVELADA"
                     /leader_location="[9830:9902](-)"
                     /alternative_weights="3813.4"
                     /alternative_weights="3831.4"
                     /alternative_weights="3849.5"
                     /alternative_weights="3867.5"
                     /alternative_weights="3885.5"
                     /alternative_weights="3903.5"
                     /alternative_weights="3921.5"
     gene            complement(10001..13057)
                     /locus_tag="CCZ36_RS18200"
     CDS             complement(10001..13057)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="CCZ36_RS18200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_164873521.1"
                     /sec_met_domain="DUF4135 (E-value: 8.8e-65, bitscore:
                     217.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.7e-32, bitscore:
                     111.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSHDVSPGTAEALRTYLPELTDPELIAHVEERLRAAATADEGEQ
                     NQELPDAPPAYDPSVDPDGLFHDYFRHFVAPRTGLVRHAAAQSPVIAAPRRIVDDFVTH
                     QTGLVSRLMIRTLVEELHRRRTAGLLDGDTPEERYAAFRRWTNSPGGHRELTARYPYLF
                     STVSRQVEASARYVVEIIEELDSSATRLGALLPAGGPELPRVERLVLGEGDTHNGGRSV
                     AQVLFTDGARVLYKPHPIGAEAGYSAFVSWMNGRIGTDLPTVAVVPTEHGGFVEFIPTE
                     EYAGEQKDYFARIGTLAGILFLLRATDIHFENMVSCAAGPVVIDTETLLSPRLNLPEAY
                     DDGAASTIGALTLRESIIGSGLLPLVVRSGDDDEGMDIGAIGYDTGQRSPYKSLSLQNP
                     GRDDMFVGMVTTTTTAANANLAVQRATQLPVNDQRDLVKREFGRVLRYAADHPDAVVHA
                     VEEFLGDVQFRHVNQATIFYTQLLRMATHPHAMADPVVRSAVLNRVVLRTGDSPAIADA
                     EVRQMARGDVPYFSYTARSRALGSTDGTVRADALAEPPLTTVRERIHGLDETVIERELR
                     LIDFSFVNKLPTDQEETGFVPVRPAGKPAVTVDRGRFVGEAVRIGERLLATRVASTEPR
                     HPATWIAPQVTTDSQSQWSPGTLGYDLYGGSPGPALVLAALARETGRADFAAAARSVLD
                     PVEEQLRGGRLAEQGVSVGGMTGMAGTAYALVVARGLLDEPDAGRLGELARELARCSGA
                     EAGTDFLSGMAGAMAVGLALHERATDPAERAVVAEAVRTIAARETEALGGPGLEDPRVT
                     PYTGYAHGAMGIAPVLLRYGAEFNDRDVHGLGLRILGAVLDAQEDGDRDWPRVWGEPER
                     SYGWCHGAPGMLLGALMSNEHAPGAVSRPVLDRLAGLTLARGFGNNPTYCHGDLACAEI
                     VGLGQQLVPGLFGAAVDRTGEGSRAGSHGDGLDDLYPRLFDEVVERYGQRSDTKYAYTN
                     SLMVGEAGLAWSVLRHLDPEGHPSLLRFA"
     misc_feature    13144..13160
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.51"
                     /tool="antismash"
     gene            complement(13155..13340)
                     /locus_tag="CCZ36_RS18205"
     CDS             complement(13155..13340)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF000539.0"
                     /locus_tag="CCZ36_RS18205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_030075698.1"
                     /sec_met_domain="mature_ha (E-value: 4.8e-08, bitscore:
                     31.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANPNVGILEEIDDQNLDAVSAAGQGWGTIVSSLSCYGASYVLGN
                     NGNFCTATAECQNNCK"
     CDS_motif       complement(13272..13340)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MANPNVGILEEIDDQNLDAVSAA"
                     /locus_tag="CCZ36_RS18205_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13155..13271)
                     /prepeptide="core"
                     /locus_tag="CCZ36_RS18205_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.30"
                     /molecular_weight="3793.1"
                     /monoisotopic_mass="3790.7"
                     /core_sequence="GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MANPNVGILEEIDDQNLDAVSAA"
                     /leader_location="[13271:13340](-)"
                     /alternative_weights="3811.2"
                     /alternative_weights="3829.2"
                     /alternative_weights="3847.2"
     gene            complement(13539..14621)
                     /locus_tag="CCZ36_RS18210"
     CDS             complement(13539..14621)
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514047.1"
                     /locus_tag="CCZ36_RS18210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_069737651.1"
                     /transl_table=11
                     /translation="MTSRTVTLLDVARAAGVSKSTVSDALQGSGRVADATRDRVRAVAE
                     ELGYRPNSAARRLRRASTGAVGLHLPATATRLDYYMNLAFGAVERAQEDGLDMVLLAPS
                     GAAGGRIASRVDGLLVIDPEAGDSAVPGLLDAGVPVVTGERYLGPAAGPSAAVVCDNAA
                     SLTALLDHVTERGARRPAVLAPSGSSAWATALRATARSWGRAHGVEVALRTVPFAATPA
                     EAEETTRALLTADPAVDAVICAPDGSAPGVLRAAAALGRDAGQVGDGAGHGVGLEAGLE
                     VGRTGGSGTTGAGLLVASCVDGPATRNAEPPVTAVDLRPAAYGRACAELLCDILADRAA
                     PDTVRRHAWSLETRASTGPA"
     CDS             14626..14790
                     /gene="allorf_3962821_3962985"
                     /locus_tag="allorf_3962821_3962985"
                     /protein_id="allorf_3962821_3962985"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKSRRRRPYGPEGCRNVPAGLDSIRCRNVPAGFAAPVLPSALPPS
                     PRPWNRSCV"
     CDS_motif       14626..14721
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MKSRRRRPYGPEGCRNVPAGLDSIRCRNVPAG"
                     /locus_tag="allorf_3962821_3962985_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       14722..14790
                     /prepeptide="core"
                     /locus_tag="allorf_3962821_3962985_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.50"
                     /molecular_weight="2308.7"
                     /monoisotopic_mass="2307.2"
                     /core_sequence="FAAPVLPSALPPSPRPWNRSCV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKSRRRRPYGPEGCRNVPAGLDSIRCRNVPAG"
                     /leader_location="[14625:14721](+)"
                     /alternative_weights="2326.7"
                     /alternative_weights="2344.7"
     misc_feature    complement(14686..14699)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 21.07"
                     /tool="antismash"
     gene            14781..15725
                     /locus_tag="CCZ36_RS18215"
     CDS             14781..15725
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983325.1"
                     /locus_tag="CCZ36_RS18215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbon-nitrogen hydrolase"
                     /protein_id="WP_128818120.1"
                     /transl_table=11
                     /translation="MRLITAYNPPASPTRTRPAERAPLRVAAVQQRWHRDPAEHRAALL
                     EGIRLAAGEGARVVCLQELTLSPYFAVVRRADHPEPAAPEELLTGPTFTFAAEAAREHG
                     VYVHASLYEKAPAPGGEDDGLGYNTAILVAPDGTLAQRTRKTHIPVTEGYYEDDWFRAG
                     PAGDDAFPLVEVDGARFGLPTCWDQWFPELARAYSLAGADVLVYPTAIGSEPGFPGFDS
                     QPLWQKVITGNAIANATFMVVPNRIGAENGLTFYGSSFIVDPYGRVLAQAPRDEPAVLV
                     ADLDLDARRDWLELFPFLTTRRPDAYGPLTETR"
     gene            15933..16979
                     /locus_tag="CCZ36_RS18220"
     CDS             15933..16979
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016640948.1"
                     /locus_tag="CCZ36_RS18220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_335755806.1"
                     /transl_table=11
                     /translation="MLSPTESAAASTDGTPAPNGPEPTASDSTGSDPAGPSPARSAARR
                     RGACRVLAGAAVVWAAAMALHASIPNAGVNAGSLFQTLLPWTGLGVPFLLVLAAVLRSR
                     LAAVAVLAPAVVWVTLFGGALADKRSGGGDLTVVSHNVDEGNPDPAGTARVLAAAGADV
                     LALEELSDASAAVYSRELAAAYPHHAVIGGVGIWSRHPLADVKEVPIMPWTRAMRATVR
                     APEGPPVAVYAVHLASVRVSAAGFTTGRRNEAARELAAALRAEPAPRVVVLGDLNGTYR
                     DRALAPVTSRLRSAQGEAGAGLGFTWPAAFPAVRIDDVLVRGMTPRAAWTLPATGSDHL
                     PVAARLSQ"
     gene            17061..17831
                     /gene="cseB"
                     /locus_tag="CCZ36_RS18225"
     CDS             17061..17831
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="cseB"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967602.1"
                     /locus_tag="CCZ36_RS18225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="two-component system response regulator CseB"
                     /protein_id="WP_069740756.1"
                     /transl_table=11
                     /translation="MTSKAQVGSVSEARGPAPGPGPAPVGVLVVEDDATIRRAVQLALE
                     RYGYRVDVAADGLSGLEAFRAGGHDLLILDVMLPELDGIGLCHRIREESPVPVLMMSAR
                     GDALDVVAGLEAGADDYVIKPVDTAVMVARIRALLRRATFGPDPENPASKRPDRAPDHI
                     LTFGDLTVDTLGMEVRRAGATVSLTPTELRLLLEFAAAPGSVLDRRRLLREVWDYGWEG
                     DTRVVDLCVLRLRKKIGSGRIETVRGFGYKLVRG"
     gene            17848..19128
                     /locus_tag="CCZ36_RS18230"
     CDS             17848..19128
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018960853.1"
                     /locus_tag="CCZ36_RS18230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_128818121.1"
                     /transl_table=11
                     /translation="MDLLNPRALRWKIAALAAAACCAVAAVVGFLVHDATRERGLSVGT
                     DRTLTRLIAAEREYGRTGKAPADIDVRSRDELPEPLARDLATLAEKETGPPDTGAYATW
                     YDADPPNWFWMWGAVAVDEDRFLVVRDDMSTEVRSLQLLDRSIVKSVLAALLFVVPLAA
                     LATEPINRRLRHGARTARRIADGDLDARIGTTGRARDEITEMASAVDDMAAALQRKLEN
                     ERRFTADVAHELRTPLMGLVTAAGLLPEDDEAAGLVRDRLRSLNALVEDLLEISRLDAG
                     AERARLDPVPLGELVTDVVRRTGTDTRVTVAEAAVVETDPRRVERIVVNLVTNAHRHGA
                     APVEVAVAGARITVRDRGPGFPPDLLERGPQRFRTGASERGRGHGLGLTVAQGQSEVLG
                     ARLTFANAPDGGAVATLDLAPLPPAAA"
     misc_feature    19137..19151
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.69"
                     /tool="antismash"
     gene            19394..20314
                     /locus_tag="CCZ36_RS18235"
     CDS             19394..20314
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447065.1"
                     /locus_tag="CCZ36_RS18235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase"
                     /protein_id="WP_079133907.1"
                     /transl_table=11
                     /translation="MVLVAGTGGWYAAGGGGRSTTAPGGDGSPGEGVAPLARSLHLPWP
                     REGQASVAVEGIGSLGTRGEQKPVPIASVTKVMTAYVILQDHPMRADAPGATVVADQRA
                     ADESYSSVETTAPVLAGREYTQRRLLELMMVPSGNNVARLLARWDAGDEKAFVAKMNRT
                     AAGLGMRATTYTGVSGMEASTRSTSADQLTLARAAMKDPAFRQIVATASVAAPGAGVTF
                     RNTNKLLGHDGVIGLKTGSSTPAGGNLVWATRQKIAGADRLVLGVVLHQRAGTTPAEGS
                     AAAHEASRALIAALRAELPAAANRA"
     gene            complement(20333..21445)
                     /locus_tag="CCZ36_RS18240"
     CDS             complement(20333..21445)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126215.1"
                     /locus_tag="CCZ36_RS18240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADH:flavin oxidoreductase"
                     /protein_id="WP_128819586.1"
                     /transl_table=11
                     /translation="MSATARAASALSRPFSVRGLTARNRIAMAPMTRQFSPDGVPGQDV
                     ADYYTRRAAADVGLIITEGTYVDHESAGTSDRVPRFHGEAALAGWGHVADSVHRAGGAI
                     IPQLWHVGVTRTEGAGPVPDAEPVGPSGISLSGEPKGRAMTQKDLDDVIAAFADAAAAA
                     ERLGFDGAELHGAHGYLIDQFLWSGSNRRTDAYGGDLVARTRFAAEIVAACRAAVSDAF
                     PLFFRMSQWKADAYEAKLAETPQELDALLTPLAEAGVDVFHASTRRYWLPEFEDSDLNL
                     AGWVKKISGRPTLTVGSVGLDGDFFSAFQGNDSSVTGIEQLLDRMERDEFDMVAVGRAL
                     IADPEWAAKTLRGRTEDITPFAAEMLKTLH"
     CDS             complement(21499..21603)
                     /gene="allorf_3969694_3969798"
                     /locus_tag="allorf_3969694_3969798"
                     /protein_id="allorf_3969694_3969798"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MPTLYRRRGRSRDVHAARACWPRVDTPATDRTST"
     CDS_motif       complement(21553..21603)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MPTLYRRRGRSRDVHAA"
                     /locus_tag="allorf_3969694_3969798_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(21499..21552)
                     /prepeptide="core"
                     /locus_tag="allorf_3969694_3969798_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.60"
                     /molecular_weight="1843.0"
                     /monoisotopic_mass="1841.9"
                     /core_sequence="RACWPRVDTPATDRTST"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPTLYRRRGRSRDVHAA"
                     /leader_location="[21552:21603](-)"
                     /alternative_weights="1861.0"
                     /alternative_weights="1879.1"
                     /alternative_weights="1897.1"
                     /alternative_weights="1915.1"
     gene            complement(21642..22652)
                     /locus_tag="CCZ36_RS18245"
     CDS             complement(21642..22652)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010063121.1"
                     /locus_tag="CCZ36_RS18245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleotidyl transferase AbiEii/AbiGii toxin
                     family protein"
                     /protein_id="WP_128818122.1"
                     /transl_table=11
                     /translation="MSSEQRPPFPEVVPASGPVPPSAGLDARRRFLDAVPGTMLRVMDD
                     EAVQRTVFDPALKQFPNAFRATDPVFPSPAATRAWQRARAAALAAVQDGVAASPWAEAL
                     VVRGSALMALWFGEEAREPGDLDFVVAPASWRMEEERTPELLAGVAAAAEARAARGAHG
                     VRIRAAGAVCEDIWTYERVPGRRMMLPWEAPGTPGGWVQLDFVFGEQLPEPPERIVLPS
                     GAVLYGATPALSLAWKVMWLINDAYAQGKDLYDATLLAERHPLPFALLQEVFRLGGEWP
                     ETGRTWVGREDLDEGLGYVEWHHFAGEYPRFEGRGEEFARRLRAALAPTFADEPG"
ORIGIN
        1 gctgaccacc ttcgacgcgg gccggcacat cgaggacgcg ctgcgctcgg gggcggtcgg
       61 tttactgatg aagaacacgg ccccggaaca gctcgtccac gcggtccgcg tgctggccgc
      121 cggcggccgg attctggcgc ccgaggcggt cggccccgtg atcgagggct acctcgccgc
      181 gggccggggc aagggtgcgg ccgaccgcac cggggccctg accgaccgcg agggccaggt
      241 gctggccctg gtcggcgcgg gcctgtccaa ccgggagatc gcccgtgagc tgcggctctc
      301 ccacggcacg gtgaaggacc acgtcagctc ggtgctgtcc aagctgggcg gggttaaccg
      361 ggtccaggcg gcggtgctcg cggaccgggc gggcctgatc gacggggcgt tgtgagccgg
      421 tccgatcggc ggggcgcggg gggccgatcc ggccggcggg gtgtcatgac gtacgtccgc
      481 cgcatgtctc tcacctgccg tacgtctctc acctcccgcc ggacgcgggc cgtcggccgt
      541 gccgccgtgc cggtcgggat cgccgtgggc gacggtctcc tcgtcaacgg cttcgggacc
      601 ggacccggcc tctgggtcgc gctcgccgcg gcgggcgcgc tggtgctgcg gcggcggtgg
      661 cccgaggtgg tgctgctcgt cggcctgccc ggcatgtacg tcggccacct ggccttcgcc
      721 ccgctgatcg cgctctactg cctcgccgac cgccgccgca acgtggccgt cggagccgtg
      781 ggcgccgtcg cggtcgccct ggcgcagttc ctgccgtacc cggtcacgga cctgccggag
      841 ctcgcggtcg accgggagac cctgatcatg gcgatggact cctgcgtcct ggccgtcggg
      901 gcgctggtcc tggggcgtac ggcccgggtg cgccgcgagc ggcagcggga gctggcggag
      961 ggccgggagc gcgagcaccg gctcctcgcc gagcggaccc tgtccaccga acgggcctgg
     1021 ctggcgcggg agatgcacga cgtcgtcgcc caccaggtca gcctcatcag cctccaggtc
     1081 ggggcgctcc aggtcggcga accggacgcg gccaccgtac ggtcgaccgc cgggaccgtc
     1141 cgcgagctct ccgtgaagac cctcaccgag ctccagcaca tggtgggcgt cctgcgggcg
     1201 gccggcggtc ccgcgcccgg cctcgacccg cagccccggc tcacggacct gcccgccctg
     1261 gtccgcgact gcggtctgcg cgtcaccctc gccgccccgg acacccccgg ccactggtcg
     1321 caggcggtgg agcgggccgc ctaccggacg gtccaggaag ccctcaccaa cgtgaccaag
     1381 cacgcccccg gcgccgaggt ggacatacgg gtccagcctc tggacggcgg tctgcgggtc
     1441 gacgtccgca acaccgccga cgacggttcc gccgcccccc tcggcctgcc cgccggcggc
     1501 cacggtctca tcggtctgcg cgaacgggcc ctgctgctcg gcggcacctt cgaagccggg
     1561 cccgagccgg gcggcggatt ccggatccag gccgtgtttc cttcccggca gactttctga
     1621 gggtgtgtcc accggcacgg aatccgtctt tccggtcctt ctccgggagg agatcgaaga
     1681 tcccggaccc cgccgaccgg cggggggtgc ccccgtcaat tgaccggata attcggaccc
     1741 cgctccctta agtgtatggc tgcttgctgt catttccctg ggaaagatag gatcgctgcg
     1801 cgccttgacc agcgcacgcc gtgcgggggc cgtcgtgacg gatccgccct gccggcggcc
     1861 gtacggggga agtagggcag aaatggcaga tgactgtata gccgtggggc tgatggtcgc
     1921 cagattgtcg ttgcggcgga gactcacccg gctcttcgcc catcgtggct ggaacgccgt
     1981 cgcgtgcgag ggggccgggg ggctcctgtc gtccggcgac cggtccggcg tctcgtcggg
     2041 ggtttcgccc gggcttccgt ccggggtttc gtccgacgtt ctggtcgtcg acatcgaccg
     2101 gctcgacgag atacggggca ccacgccggt cgtggcgctg acctacggct cggagatcga
     2161 ccgtctcgga gcggtgaaag ccgacgtccg cgcggtcgtg gaccgggacg acctggacga
     2221 ggccttcctg gaggccgtgc aggaggtcgc cgccgggcac gggtggatat cgcccacgct
     2281 cgtccgtccg ctgctgcgcg ggcagccgtc ggcaccggcg ggggccgtcc ggccgaccgt
     2341 cgttcccgca caggtgcacc ggccgggccg gccgcacgat ccggccctga cggcacggga
     2401 gtacgaagtg gtctccctgg tgtcgaaggg aatgaacaac agtgagatcg ccggcgccct
     2461 ctatatcgcg gagagcaccg tgaagttcca tatgtcgaac attctgcaga agaccggatt
     2521 ccgtaaccgc ggtcagctcg tggcgcgtat gccggtggcc ggctgaaccg gccgcacaca
     2581 acatggagga gaccgtcatg ggaaatgtcg tggggaagaa gaaggaagcc cttcgctggg
     2641 cgccggtggt cattctgctg gtgttcgcgc tgatcgcgcc gctcttcggg gacagcccga
     2701 ccggcgtggt gattccgctt ctgctcgcgg tgatgctcgc gggtgtcaat gtcacggtgc
     2761 agaagaagga gcgttcggcc ggcggaacgg agtgatccgg gcgggggaat gacgacgcgt
     2821 gccggggccg ccgcacctga ccagtgcggc ggccccggca tggcatcggt catgaagccc
     2881 cggtcacggc gttcccgtca cgaggcctcg taccgggtga agcgcgtcgc gcccaccgcc
     2941 ccgatcacca ccgcgtagag gaacaggacc aggaagccga ggccctgcga accgccgtcc
     3001 gcctccgccg cggccgtcat gatcgtgccg ccgcccgcca ggtcgcccgc cccgccggga
     3061 agcaggttgc ccagctccgc gttgccgagc gaggaggcga ggatccgcag ggtcggctcc
     3121 acgaactgcg tcaccagcag gatgccgacg atcgccgcca cctggttgcg caccagcgca
     3181 cccacgccga cgccgatcgc gccccacagg gtcatcacca gcacgctgcc gcccagcgcg
     3241 ccgagcaccg tgccgtccgt gaggtacgtc ggcttcccgt gccccgccag cagcgccgct
     3301 gccaccaggg cgccggagag caccgccacc gctccgtaga cgaacgccgt gcccagcccg
     3361 acgacgagtt tggccccgta cacacgggcc cggcgcggct cggccagcag cgtcgccgag
     3421 atcgtgcgcg cgtggtactc ctgcgtcacc gtgatcacac cgatggccag cgggaagacg
     3481 tacgcgagcg ccaccggcag gttgtacgcc ggtacggcgt cgcccgccgc gccgaaactc
     3541 aaggggctgc gcggggcgtt gaggccgccg aagacgatca gcgcggtgaa tccggcaccg
     3601 cacgcgacga ccgcgagcag caggatccac cacagccggg tcgtggtcag cttcagcacc
     3661 tcggaccgca ggagatcggc cgtggagacc gcgccggagc cgggtgcgga gtccgtggcc
     3721 gggctcgcgc cccggcccgt ccgcgccacc gcagccgtgc tcgtacccgt acccgtgctc
     3781 atgcccgtac tccgttcccg gcccgtgtca gccgcaggaa ggccgactcc aggcgttcgc
     3841 ccggctccag cagaccgtcg agagggccgc tgatcagcag ccgcccgtga tgcatcagca
     3901 ggacgtcgtc caccgtctgc tccatctcgc cgagcagatg gctggagagc agcaccgtcc
     3961 ggcccgaggc cgcgaagtcc cgcaggaact cccgtagcca cagcatccct tcggggtcca
     4021 ggccgttggc cggctcgtcc aggatcagca gctccggatc gcccagcagc gccgaggcga
     4081 gggagaggcg ctgcttcatg cccgtcgagt acccggcgac cggccggtcc gccgcacccg
     4141 acaggcccac gtccgccagc agccggtcga cccgttcggg accgcagccg gcggccggtg
     4201 cgtagcagcg cagatggccc cgtccggtac ggcggccgac gaacgccccg ccgtccaggc
     4261 cgaccccgat ccgccgcgtg ggggcggcga gcccggcgta cgggctgccc cacagcagtg
     4321 cgctgccccc ggtcgggcgg atcagcccga ggatcatgcg cagagtcgtc gtcttgcccg
     4381 cgccgttggg gccgaggaag ccggtgacac ggcccggccg tacgtcgaag gagaccccgt
     4441 cgacggctct cgtgccccgg aactccttct ggagatcccg gaccgtgatc acctgctgcc
     4501 gcgcgtcctg tcggttctgc gtgtggtcct gcgtggtgtg cgcgtcctgt gccatgcggc
     4561 ggttcctcct tctcttatcg gaccgtgttg aggtcgacct gggagcggac caggtcccgg
     4621 tacgggccgg gttcggtgat cagctcctcg tggcggccgg tctggacgac ccggccgtgc
     4681 tccagcacca ccacgagatc ggcgttcacg atggtcgaca gccggtgggc gatgatgatc
     4741 cgcgtgcact ccagccggtc cagcgcggcg gcgatccggg actccgtgac ggtgtccagc
     4801 gcgctcgtcg cctcgtcgag cacgaggacg cgggggcggc gggcgagcgc gcgggcgagc
     4861 gcgatccgct ggcgctggcc gccggagagg ctgccgccca tctcgcggac cggggtgtgg
     4921 tagcccagcg gcatcgccgc gatgtcgtcg tgcacatgcg cctggcgcgc ggcgtcgacg
     4981 accgcctcca tcgtggcgtc ggggaccccg aagcggatgt tgtccgcgat gctgcggttg
     5041 ctgaggacga tgtcctgcgg gacgtacgcg gcgttccggt agaacgtgtc ggcgtcgatc
     5101 tcgccgatcg acaccccgtc gtagaggacg tcgccggacc ggatcgggta cagacccatg
     5161 aggagtttgc ccagcgtgct cttgcccgag ccggaactgc ccacgatcgc gacccgttcg
     5221 ccgggccgga tgtcgaacgt gacgtccgcg agggccgggg tgcgggagcc ggggtaggag
     5281 aacccgacgt tccgcagtcg caccgcgccc cgcacggcga ccggccggtc gccgaacgcc
     5341 cccgggtcct ccggctggtg gaggatgtcg ccgacccgcg cgacctgcgc gttcgccgtg
     5401 atcagctggg tgaacgcgcc ggacagcgac atcaccatgc cgaggctcgt cgcggtcagg
     5461 gtctgcgccg ccacggccga accgaggtcc agcgaaccgt tcagcacgag ccacagcccc
     5521 accgccagca ccagcagcgg accgaacacc tggaacaccg cgtaaccgct ggtcgccacg
     5581 ccctggagga cgatccgccg ccgggtctgt tccatccccg ccgcgtagac ccgctgccag
     5641 tcccggaaga aggtgccggt catcccggag accttcagcg tctcgatcga ggacagcgcc
     5701 tccatctgga gcgaggagga cttcgtcgtc tcgctgatct cccgctcggt gatccgccgg
     5761 atcggccggt acgtccccac ggccacggcc agcatggtca ggaagaccgc gaacgccgtc
     5821 gccccgaggg tgaacgagcg gtagaacatg tagctgaaga tcgcgatcag gctgccgaga
     5881 tcgaggagta ccaccgacag ctggctggag atcatgtccc gtacggacgt gatgctggag
     5941 agccggtaga acagctcccc ctgcgagcgg ttggcgaagt acttgtaggg cagttccagc
     6001 agccgccgga acgtcttccc catcatcgcc tcgcccaggc tccggatcac ggacgccagc
     6061 gccaccgttc tgagcagcga gagcaggaag aacaccgtca tcggggcgag gaacgccacc
     6121 aggaccaggg cgatcggggc cctctccaga tagcccgcgt agtcgttgac cgcgtactgg
     6181 gtggcgatcg gcatgaagat ggtgaaggag tacagcacca gggacatcag gaacgcctgg
     6241 agcagcggct tccgggcgcc ggtcagagag cgcaggaact cccgccagac actgggctcc
     6301 cggtgccgct cgggccggtg gtccggcgtc ggtacggctt cgagcgcgag gccggagtag
     6361 tgctcggcga actcctccgc cgagtacctc cgccgcccgc cgcccgggtc gacgacggtc
     6421 acccggtgct cgtcgatctc ctcgacgacc acgacatggc tgtcgtccca gtacgcgatg
     6481 agcggcagct ccagctgatc gagccgctcc accccggccc ggaacgcccg cacctcgaag
     6541 ccccggccgc gcaggatggc cgcgatctgc ttgatggtga ggccgtcgcg ccccacctcg
     6601 tggtcccggc gcagcccggc caccgaatcg cgggagccgt acgccgagag gatcatcgcg
     6661 atgcagcaca gaccgcattc ggcctgggcg aactgctgga cctcgcggac ccgtcggact
     6721 ctgcgcatac gccatgccat cagcggcctc cgaggcagcg gggaaggccg gttccggggt
     6781 ggtcgagcat cgcctgggcg gcgaaccagc cggagaggcc gaggaagtag gacggcagga
     6841 ggggttcggt gccgatcccg caggaccagc cgccgttccc gtaccggtcg aggaaggcgg
     6901 tgtgcagcgc ggcggccgcg tcgcgcaggt cgggccgggc gagcaggtcc gccaggtggc
     6961 acaggaccgc gatccggccg gcgagcccgt ggcagaggct gaggtcgggg gcgatcgcgg
     7021 tgctccgtcc ggccccggcg ggctccgtga cgcgggcgat ctccggggcc acggcttccg
     7081 cgatccggcc ggccggttcg ccgagggcgg tgagcagagc ggcgtgcgcg tacgcgatgc
     7141 ccgcgtaccc cttgcaccag ccgccgttgc cgcctccgtc ccccggtcgc gcaggcccgc
     7201 gtcctgccag cggtggcgac cgtacgcctc ggcgaaccgc tccagatggg cgcgggcgcc
     7261 gctgtcctcg tcgaggcccg ccgcgaccat cgctgacagg gcggtgatcc ggccgaacct
     7321 gccgtgggcc aggccgagtt catccccctc ggggtgctcg gccgggtcgc cgtccaccgt
     7381 gacgaggcgg cgcagcagcc gttcggcccc ggccccggtg acctcggtcg cgccgtgctc
     7441 ggtgtgggcg gcgaggtgga cgaggtagcc gccgtagccg ttgaggtggt cgaagtcggc
     7501 ggcggagagg ccgtcgacgt cgaacgcgcc ctggcccggg tggaaccgga cgtgctcctc
     7561 gcccgcccgg aaccgggcgt cgggcgaggt cagccgccgg atctcccagt cggtcaccag
     7621 gtcggagagc gcgccggtga acggcgacat cgacagcggc gtcccgtcga gcacggccgg
     7681 ccgggagcgc acggccgagg cgcagacccg ctccgggtcc acacccacgg gggacacgcc
     7741 ggtgcgggcc gcgctctgcg cgaggtgcag cagcagcccg ccgccgtcgt acagcgtcgc
     7801 gtcgatgccg ccgaggcgga gcccgtcgcc ccggaggcgg ggcgtcagcc aggtcggggc
     7861 gtccgccccg ccgacgacga ggtcgccgag cagggcgtgc cagccggccg ggtcggcgag
     7921 gtggacgggt gaggtggtcg gggcgggccc ggtggcgggc tcccgtcgct cccacacgtc
     7981 gtcggcggaa ccggcgagtg cgtagcggag gtagagcggg tcgcggtcgg cgggccgggc
     8041 gaagaacgat cgtacggcgg cgagcgcgga ctcacggggt gtgagccggg cggcgctgcg
     8101 gatctcctcg tcgaagtcgc cgcgcagcag cccggagtcg cagtccacgg tgaagaacgg
     8161 cacatcgagg tcgaggaggg cggcgacctc ctcccggtgg accgcgtcgg ccgatgcggc
     8221 ggcggtgccc cggtagtggc gcggaagttt cccgagcagc tcggcccggt cctgccggct
     8281 gcccaggtgc acggggtgcg tggaggcctc caggaaccgg gcgtagacgt aggtcgggcg
     8341 gacgacctgg cgcacggccc acccggcgga ttcccgtacg gtcgcttcca cggcgtcgcg
     8401 gtgggcggcg agcagggtgc gggcctcgcg gaatccggcg acgagctcgt ccgtccagcg
     8461 gcgcgggtcc agcggctcgc ccgccacggt ggccatgttg gagccgtgct cgacgacgac
     8521 ctggctgcgg tcgaagcgga tgtcgtccgt gcccgcgtcc acgaccaggt acgactggag
     8581 gtgctcggag gccccgggcc gcacgcagcc gatcccggag atgtccacgt ccagcttgga
     8641 tgcggcgtaa cgggcgggaa agagcagggt gttgagcacc gagtgctcga tgtcgcggtt
     8701 gagggcggcc gcggccggca tcgaaccgcc ctgctccggt gcggtgttgg gcagcgacac
     8761 cagggtctcg gtgtcgatga cgaccgggcc ggccggggtg gcgatgatgt tctcgtggtg
     8821 caggtcggtg gcgcccagca tcgacaggag cgcggcggac cggccgaaac ggcggaagta
     8881 gcgggcgctg tgctccgccg taccgtcgag gtcggcgtgg accacgaact cctgccagac
     8941 gtgcgcgggc cgaacgaggg tgcgggggtg cagcggaccg aagaacgagc cgtccgcgtc
     9001 gaggagcgta cgcagcgagg tcaggagctg ctggcagttg tcctgctgcg gcttgtacac
     9061 ggcccgcgtg ccgtcgtccc ggaccaccag gcagacggtc cgcccgcccc ggtgggcgtc
     9121 gccgaggccc ggggtgaccg agacgatccg gccgggcccg ccgaggagcg cgtccagctc
     9181 cgcccggtcc gcgacggcgg cgtgcagcac gtcggccacc gtgcgtgcgg tacgggcggt
     9241 ggcgaggcgc agcagccggt ccagctcggg gaagcggtcg agcaccgcct ggcggccggt
     9301 ggcccgggcg aggcgggcgt ggaacgcctc gtacccggtg tcctgggcgc ggaaggaggc
     9361 gatgagggtg cggacgccgg tctcgacgca gaggcccatg agcgagcgga gcgcggactc
     9421 ggcgaccccg gcgaggtcgg ctgtgtcctc catcgtgtcc gggcccggga gggcggcggc
     9481 gagcccggcg acgcgctggg cgccgtcccg cagatacggc gtgtagaacg cgccgaagac
     9541 gtctgacctc tcgtcggtga tgcgccgcac caggtcgtcg aggaacgcgt cgctcagttg
     9601 cactcgggga ctctcttgcc gtcgtcgaag gtgggagggt ggggacgggc gccccggaag
     9661 taccagttcc ggggcgcccg caccgcaccg gctcagcggg ttcagcagcg cttggtgcag
     9721 ccgctcgtcg ggcagccgcc ctgcatcgcg gcgctggcgc cgacgatcac ggtggtgacg
     9781 gcggtggccg ggacgatggt gggcgtgatg cccgcggcca gcgagtccgg cgcgtccgcg
     9841 agctcgacga gctcgtcggc gctgacgtat ccggtggcgt cgttcatggc gatgtcgccc
     9901 atgacggttc ctctctgttc ttcctgcgtg gatgggtggt gcagggcccg gcaggatgcg
     9961 ggcccggttc gtgggtgcgc cgtcgtgtcc cggccgtggc ctaggcgaag cgcagcaggg
    10021 aggggtggcc ctccgggtcc aggtggcgga ggacggacca ggcgagtccg gcctccccga
    10081 ccatgaggct gttggtgtag gcgtacttgg tgtccgagcg ctgcccgtac cgctccacga
    10141 cctcgtcgaa gagccgcgga tacaggtcgt cgaggccgtc gccgtggctt cccgcccggc
    10201 tgccctcgcc ggtccggtcc acggccgcgc cgaacagccc ggggaccagc tgctgcccga
    10261 gaccgacgat ctccgcgcag gccaggtcgc cgtggcagta ggtcgggttg ttgccgaagc
    10321 cgcgggccag ggtcagcccg gccagccggt ccaggaccgg gcgggacacg gcgccgggcg
    10381 cgtgctcgtt gctcatcagc gctcccagca gcatgccggg ggccccgtgg caccagccgt
    10441 acgagcgctc cggctcgccc cagacgcgcg gccagtcgcg gtcgccgtcc tcctgggcgt
    10501 cgaggaccgc gccgaggatc cgcagcccga gcccgtgcac gtcccggtcg ttgaactcgg
    10561 ccccgtagcg cagcagtacg ggtgcgatgc ccatcgcccc gtgtgcgtaa ccggtgtacg
    10621 gggtgacccg ggggtcctcc aggccggggc cgccgagcgc ctcggtctcc cgggcggcga
    10681 tcgtgcggac cgcctcggcg acgaccgcgc gctccgccgg gtcggtggcg cgctcgtgca
    10741 gggcgaggcc gacggccatc gcgcccgcca taccgctgag gaagtcggtg ccggcctcgg
    10801 cccccgagca ccgggccagc tcccgcgcca gctcgccgag gcgcccggcg tccggctcgt
    10861 ccagcagccc gcgggccacg acgagcgcgt acgcggtacc ggccatcccg gtcatcccgc
    10921 ccacggacac cccctgctcg gcgagccgcc cgccgcgcag ttgctcctcg acggggtcca
    10981 gcacgctgcg cgcggccgcc gcgaagtcgg cccggcccgt ctcgcgggcg agtgcggcga
    11041 ggacgagggc ggggccgggg ctgccgccgt acaggtcgta gccgagggtg ccggggctcc
    11101 actggctctg cgagtcggtg gtgacctgcg gggcgatcca ggtcgccggg tggcggggct
    11161 cggtgctcgc cacccgggtc gcgagcagcc gctccccgat ccgtacggcc tcaccgacga
    11221 accggccccg gtccacggtg acggcgggct ttcccgccgg gcgcacgggg acgaacccgg
    11281 tctcctcctg gtcggtgggc agtttgttga cgaacgagaa gtcgatcagg cgcagttcgc
    11341 gttcgatgac ggtctcgtcc agcccgtgga tccgctcgcg cacggtggtc agcggcggct
    11401 ccgccagggc gtcggcccgt acggtcccgt ccgtcgagcc cagcgcgcgc gacctggcgg
    11461 tgtacgagaa gtacggcacg tcgccccggg ccatctgccg gacctcggcg tcggcgatcg
    11521 cgggggagtc gccggtgcgc aggacgaccc ggttcaggac ggcggagcgg acgaccgggt
    11581 ccgccatggc gtgcgggtgg gtcgccatgc ggagcaactg cgtgtagaag atcgtcgcct
    11641 ggttgacgtg ccggaactgc acatcgccga ggaactcctc cacggcgtgg acgaccgcgt
    11701 ccgggtggtc cgccgcatac cgcagtaccc ggccgaactc ccgcttgacg aggtcccgct
    11761 ggtcgttgac gggcagctgg gtggcgcgct gtacggcgag gttggcgttg gcggccgtgg
    11821 tcgtcgtggt caccatcccg acgaacatgt cgtcgcgccc cgggttctgg aggctcagcg
    11881 acttgtacgg ggaacgctgc ccggtgtcgt agccgatcgc gccgatgtcc atgccctcgt
    11941 cgtcgtcgcc cgagcgcacg acgagcggca gcagccccga cccgatgatc gactcccgga
    12001 gcgtgagcgc cccgatcgtg gaggccgcgc cgtcgtcgta cgcctcgggg aggttcagcc
    12061 ggggcgacag cagggtctcg gtgtcgatga cgacgggccc ggcggcgcag gacaccatgt
    12121 tctcgaagtg gatgtcggtg gcccgcagga ggaagaggat gcccgcgagg gtgccgatcc
    12181 gggcgaagta gtccttctgc tcgcccgcgt actcctcggt ggggatgaac tccacgaacc
    12241 cgccgtgctc ggtggggacc acggcgacgg tcggcagatc ggtgccgatc cggccgttca
    12301 tccaggagac gaaggcgctg tagccggcct ccgcgccgat ggggtgcggc ttgtagagca
    12361 cccgggcgcc gtcggtgaac aggacctgcg cgacggagcg tccgccgttg tgggtgtcgc
    12421 cctcgccgag gacgagacgc tcgacgcggg gcagttccgg accgccggcc ggcaggagcg
    12481 cgcccaaccg cgtcgcggag gagtcgagtt cctcgatgat ctcgacgacg taccgcgcgg
    12541 acgcctcgac ctggcggctc accgtcgaga agaggtacgg atagcgcgcg gtcaactcgc
    12601 ggtgtccgcc cggactgttg gtccaccgcc ggaaggcggc gtaccgctcc tcgggggtgt
    12661 cgccgtccag caggcctgcc gtgcgccgcc ggtggagctc ctcgaccagg gtccggatca
    12721 tcagccggga gacgagtccc gtctggtgcg tgacgaagtc gtcgacgatc cgccgcggcg
    12781 cggcgatcac gggcgactgc gcggcggcat ggcgtacgag gccggtccgg ggcgcgacga
    12841 agtggcggaa gtagtcgtgg aagagcccgt cggggtcgac ggaggggtcg taggcggggg
    12901 gcgcgtcggg cagttcctgg ttctgctcgc cctcgtccgc tgtcgccgcc gcccgcagcc
    12961 gttcctcgac gtgcgcgatc agctcggggt cggtgagctc cggcagatac gtccgcagcg
    13021 cttcggcggt gccgggggag acgtcgtgac tgttcatgaa caccggatcc aggacggggc
    13081 ggggcagggc gggggggtcc ccctcgggag gggagggggg gtgacgccgg gaggtgggtc
    13141 ccggcgtcat acggtcactt gcagttgttc tggcactcgg cggtggccgt gcagaagttc
    13201 ccgttgttcc ccaggacgta gctggcgccg tagcagctga gggaggacac gatggttccc
    13261 cagccctgac cggcggcgct gacggcgtcg aggttctggt cgtcgatctc ttcgaggatg
    13321 ccgacgttgg ggttcgccat gaggctcaca cctttcacgc gaggaagcgg cgcggctgtg
    13381 cggccgggcc gttccgaatg gatcttgacc ccatgaacgc tagggatccg atccgcgatg
    13441 cacccccgcc cggggacggg ttccgccccc gccctggggc gtgttgttcc cctaccggat
    13501 cctcgccggg cggggtggtg gggggcgtgg tgtgttgctc aggcggggcc ggtggaggcg
    13561 cgggtctcca gggaccaggc gtggcggcgg acggtgtcgg gggcggcccg gtccgcgagg
    13621 atgtcgcaga gcagctcggc gcaggcgcgg ccgtaggcgg cggggcgcag gtcgacggcg
    13681 gtgacgggcg gctcggcgtt gcgcgtggcg gggccgtcga cgcaggacgc gacgagcagg
    13741 ccggcaccgg tcgtaccgct tccgccggtc cgcccgactt cgagaccagc ttcgaggccg
    13801 actccgtggc cggccccgtc gccgacctgg ccggcatccc ggccgagagc ggccgccgcg
    13861 cgcaggacgc ccggggccga tccgtcggga gcgcagatca cggcgtcgac ggcggggtcc
    13921 gcggtgagca gggcccgggt cgtctcctcg gcctccgccg gcgtcgccgc gaacggcacg
    13981 gtgcgcagcg ccacctccac cccgtgggcc cgcccccatg accgggccgt cgcgcgcagg
    14041 gcggtcgccc aggcggagga gccggacggg gcgaggacgg cggggcggcg ggcgccgcgc
    14101 tcggtgacat ggtcgaggag ggcggtcagc gaggcggcgt tgtcgcagac cacggcggcg
    14161 ctggggccgg cggccgggcc gaggtagcgc tcaccggtga ccaccgggac gcccgcgtcg
    14221 agcagccccg gcaccgcgct gtcgcccgcc tcggggtcga tcaccagcag cccgtcgacg
    14281 cgcgaggcga tccgcccgcc cgccgccccc gacggcgcga gcagcaccat gtcgagcccg
    14341 tcctcctggg cgcgctccac cgccccgaaa gcgaggttca tgtagtagtc cagccgggtc
    14401 gcggtggccg gcagatgcag gccgacggcc ccggtgctgg cgcggcgcag ccgccgggcg
    14461 gcgctgttgg ggcggtagcc cagctcctcc gccaccgcgc ggacccggtc ccgggtggcg
    14521 tcggcgaccc gccccgagcc ctggagcgcg tccgagacgg tgctcttgga gaccccggcg
    14581 gcacgggcta cgtcgagcag ggtcacggtg cgggaggtca cgggggtgaa gtctagacgt
    14641 cggcggccgt acggcccgga gggttgccgg aacgttccgg cagggttaga ttcgatccgt
    14701 tgccggaacg ttccggcagg cttcgccgcc ccagtcctcc cctcagccct ccccccgtcc
    14761 cctcgcccct ggaaccggtc atgcgtctga tcaccgcgta caacccgccc gcctccccga
    14821 cccggacccg ccccgccgag cgcgcgcccc tgcgcgtcgc ggcggtccag cagcgctggc
    14881 accgcgaccc ggccgagcac cgcgccgccc tgctggaggg catccggctc gccgcggggg
    14941 agggcgcccg ggtggtctgc ctccaggagc tgacgctctc gccgtacttc gcggtcgtcc
    15001 gccgcgccga ccaccccgag cccgccgccc cggaggagct gctgacgggc cccaccttca
    15061 cgttcgccgc cgaggccgcc cgggagcacg gggtgtacgt ccacgcctcg ctgtacgaga
    15121 aggccccggc gcccggcggc gaggacgacg gcctcggcta caacaccgcg atcctggtcg
    15181 cccctgacgg caccctcgcc cagcgcaccc gcaagaccca catcccggtg accgagggct
    15241 actacgagga cgactggttc cgggccggcc cggcgggcga cgacgccttc ccgctggtcg
    15301 aggtcgacgg ggcccgcttc ggcctgccga cctgctggga ccagtggttc cccgagctgg
    15361 cccgcgccta ctcgctggcc ggcgccgacg tcctcgtcta cccgaccgcc atcggctccg
    15421 agcccggctt ccccggcttc gactcccagc cgctctggca gaaggtgatc accggcaacg
    15481 ccatcgccaa cgccaccttc atggtcgtcc cgaaccgcat cggcgccgag aacggcctca
    15541 ccttctacgg cagctcgttc atcgtggacc cgtacggccg cgtcctggcc caggcccccc
    15601 gcgacgagcc cgccgtcctc gtcgccgacc tcgacctgga tgcccggcgc gactggctgg
    15661 agctgttccc gttcctcacc acccgtcgcc ccgacgcgta cggcccgctc accgagaccc
    15721 gctgatccgc cgggccggga aaagagcgcc gcaggcgtac aggtctcggt gcggccggtg
    15781 agcgccgctt cgtcgccgca ctgcaccgat acgcacctga aacagagccg cgcggtgctc
    15841 gaagcacgcc cctgaccggc cggaagcggc gttcccggag gctgtcggcg tacccgatcc
    15901 ccggtgtacg cgaccgtcag gagacctgtg ccgtgctgag cccaacggaa tccgcagcgg
    15961 cttccacgga cgggacgccc gctcccaacg gtcccgaacc gaccgcgtcg gattccaccg
    16021 gctccgatcc cgcagggccc tctcccgccc ggtccgccgc ccgccggcgc ggggcctgtc
    16081 gggtcctcgc cggggcggcg gtcgtctggg cggcggcgat ggcgctccac gcctcgatcc
    16141 cgaacgcggg cgtcaacgcg ggcagcctct tccagacgct gctgccctgg acgggcctcg
    16201 gcgtgccgtt cctgctcgtg ctcgccgccg tactccggtc ccggctcgcc gccgtcgcgg
    16261 tcctcgcgcc ggccgtcgta tgggtcacgc tcttcggcgg agccctggcc gacaagcgtt
    16321 ccggcggcgg cgatctgacg gtggtcagcc acaacgtgga cgaggggaac cccgatcctg
    16381 ccgggaccgc gcgcgtgctc gccgccgccg gcgcggacgt actggcgctg gaggagctgt
    16441 ccgacgcgtc ggccgccgtc tactcccgcg agctggccgc cgcctacccg caccacgcgg
    16501 tgatcggcgg ggtcggcatc tggagcaggc acccgctggc ggacgtgaag gaggtcccga
    16561 tcatgccgtg gacccgtgcg atgcgggcca cggtgcgggc ccccgaggga ccgcccgtcg
    16621 ccgtgtacgc ggtccatctg gcgtcggtac gggtctcggc ggcgggcttc acgacgggcc
    16681 gccgcaacga ggccgcccgg gagctggcgg ccgcgctccg ggctgagccc gcgccccggg
    16741 tcgtggtgct gggcgacctc aacgggacgt accgggaccg cgcgctggcc ccggtgacct
    16801 cgcggctgcg gtccgcgcag ggagaggcgg gcgccggcct cgggttcacc tggcccgcgg
    16861 cgttcccggc ggtccgcatc gacgacgtgc tggtacgggg gatgaccccg cgcgcggcct
    16921 ggaccctgcc cgccaccggc agcgaccacc tcccggtggc ggccaggctg agtcagtgag
    16981 tcgctgagcc ggtgagccgg tcctcggccc tccccccgac tacgatgcga gcgaccgcct
    17041 ccgcattgcc ccgtcgaccg atgacctcga aagcccaggt aggcagcgtg tcagaagcac
    17101 gaggaccggc ccccggcccc ggccccgccc ccgtcggcgt gctcgtggtc gaggacgacg
    17161 ccaccatccg ccgcgccgtc caactggccc tggagcgcta cggctaccgg gtcgatgtcg
    17221 ccgccgacgg gctcagcggt cttgaggcct tccgcgcggg cgggcacgat ctgctgatcc
    17281 tcgacgtgat gctgcccgag ctggacggca tcggcctctg ccaccggatc cgtgaggaga
    17341 gccccgtccc ggtcctgatg atgtccgcgc gaggcgacgc cctcgacgtg gtcgcgggcc
    17401 tggaagcggg ggcggacgac tatgtgatca agccggtcga caccgccgtc atggtcgccc
    17461 gcatccgcgc cctgctgcgg cgcgccacct tcggcccgga cccggagaac cccgcgtcca
    17521 agaggcccga ccgggccccc gaccacatcc tgaccttcgg cgacctgacc gtcgacaccc
    17581 tcggcatgga ggtccgccgg gccggcgcga ccgtgtcgct gacccccacc gaactgcggc
    17641 tgctgctgga attcgccgcc gcgcccggct cggtcctcga ccgccggcgg ctgctgcgcg
    17701 aggtgtggga ctacggctgg gagggcgaca cccgggtcgt tgacctgtgc gtgctgcggc
    17761 tgcgcaagaa gatcggcagc gggcggatcg agaccgtacg cggcttcggc tacaagctcg
    17821 tgcgcggctg agcggccgcc gatcgccgtg gacctcctca atccccgcgc cctgcgctgg
    17881 aagatcgccg cactcgccgc cgccgcgtgc tgcgcggtcg ccgccgtggt cggcttcctg
    17941 gtgcacgacg cgacccggga acgcggtctg agcgtcggca ccgaccggac gctgacccgg
    18001 ctgatcgccg ccgagcggga gtacggccgt acggggaagg cgccggccga catcgacgta
    18061 cggagcaggg acgaactgcc ggaaccgctg gcgcgcgacc tcgcgaccct cgcggagaag
    18121 gagaccggcc cgccggacac cggcgcctac gccacctggt acgacgccga tccccccaac
    18181 tggttctgga tgtggggcgc cgtggccgtc gacgaggacc ggttcctcgt cgtccgggac
    18241 gacatgagca ccgaggtccg cagcctgcag ctcctggacc gcagcatcgt caagtccgtc
    18301 ctcgcggccc tcctgttcgt cgtccccctc gccgccctcg ccacggaacc gatcaaccgg
    18361 cggctgcgcc acggggcccg taccgcccgc cgtatcgccg acggcgacct ggacgcccgg
    18421 atcggcacga ccgggcgggc ccgcgacgag atcaccgaga tggcgtcggc cgtcgacgac
    18481 atggccgccg ctctccagcg caagctggag aacgagcgac gcttcaccgc cgacgtcgca
    18541 cacgaactgc gcaccccgct gatgggtctg gtcaccgccg ccgggctgct gcccgaggac
    18601 gacgaggcgg ccggcctcgt acgggaccgg ctgcggtccc tgaacgcgct ggtcgaggac
    18661 ctgttggaga tctcccgcct ggacgcgggc gccgagcggg cccgcctcga cccggtgccg
    18721 ctcggcgaac tggtcaccga cgtggtgcgg cgtacgggca cggacacccg cgtcaccgtg
    18781 gcggaggccg cagtggtgga gacggacccg cgccgggtgg agcggatcgt ggtcaacctc
    18841 gtcaccaacg cccaccggca cggtgcggcc cccgtcgagg tggcggtggc cggggcgcgg
    18901 atcaccgtac gcgaccgggg ccccggcttc ccgcccgacc tgctggagcg cggcccccag
    18961 cggttccgca ccggggcgag cgaacgcggc cggggccacg gtctcggcct gaccgtcgcc
    19021 cagggccagt ccgaggtgct cggagcccgg ctgaccttcg cgaacgcccc ggacggggga
    19081 gcggtcgcga ccctcgacct ggctccgctc ccacccgccg ccgcctgata cggaaccgaa
    19141 acgcactttc acggccgtcg aaacggtgct gtacgggtcc ggaagaacga ctcctcgaag
    19201 gtggcaccgg tacgggaaac cgcaccggtg ccacctggag gaacccatgc ccgccgtccc
    19261 cgccgtcccc gcagtttccg ctgttccccc tcccaccgga agggaggtcc tgcccaccgg
    19321 agatggcgtc cgcctccgtg cccggcttcg ccgcctccgc caccgctcgg tcctcgtacc
    19381 cctgaccgcc gccgtggtgc tcgtggccgg cacgggaggg tggtacgcgg ccgggggcgg
    19441 cggccggtcc acgaccgcgc cgggcggcga cggcagcccg ggggaggggg tggcgccgct
    19501 cgcccggtcg ctgcacctgc cgtggccgcg cgaggggcag gcgagcgtgg cggtggaggg
    19561 gatcggcagc ctcggcaccc ggggcgagca gaagccggtc ccgatcgcca gcgtcaccaa
    19621 ggtcatgacg gcctacgtga tcctccagga ccacccgatg cgggccgacg cccccggcgc
    19681 gaccgtggtc gccgaccagc gggcggccga cgagtcgtac tcctccgtcg agacgaccgc
    19741 tcccgtgctc gccgggcggg agtacaccca acgccggttg ctggagctga tgatggtgcc
    19801 ttcgggcaac aacgtggccc ggctgctggc ccgttgggac gcgggcgacg agaaggcgtt
    19861 cgtcgcgaag atgaaccgga ccgccgccgg gctcggcatg cgcgccacca cgtacaccgg
    19921 ggtgagcggg atggaggcga gcacgcggag cacgtcggcc gaccaactga ccctggcccg
    19981 tgccgcgatg aaggacccgg ccttccggca gatcgtggcg accgcctccg tcgcggcccc
    20041 gggcgccggg gtgaccttcc gcaacaccaa caaactgctc ggccacgacg gggtcatcgg
    20101 cctgaagacc ggctcgtcca ccccggcggg cggcaacctc gtctgggcca cgcggcagaa
    20161 gatcgccggg gccgaccgac tggtcctcgg ggtcgtgctg caccagcgcg ccggcaccac
    20221 ccccgccgag ggcagcgccg ccgcccacga ggcgagccgc gccctgatcg ccgcgctccg
    20281 ggcggagctt ccggcagcgg cgaacagggc ttaggaacag ctccgttgcc ggtcagtgca
    20341 gagtcttcag catctccgcg gcgaacggtg tgatgtcctc ggtgcgcccg cgcagggtct
    20401 tcgccgccca ctcggggtcg gcgatcagcg cccgtccgac ggcgaccatg tcgaactcgt
    20461 cgcgctccat ccggtccagc agctgctcga tgccggtgac gctggagtcg ttgccctgga
    20521 aggcgctgaa gaagtcgccg tccaggccga ccgatccgac cgtgagggtc ggccggccgc
    20581 tgatcttctt cacccagccg gccaggttca ggtcggagtc ctcgaactcc ggcagccagt
    20641 agcggcgggt ggacgcgtgg aagacgtcga caccggcctc ggccagcggt gtgagcaggg
    20701 cgtccagctc ctgcggggtc tcggcgagct tcgcctcgta cgcgtccgcc ttccactggg
    20761 acatccggaa gaagaggggg aaggcgtcgg acacggcggc gcggcaggcg gccacgatct
    20821 cggccgcgaa ccgggtgcgg gcgaccaggt ccccgccgta ggcgtcggtc cgccggttgc
    20881 tgccggacca caggaactgg tcgatcaagt agccgtgggc gccgtgcagt tcggcgccgt
    20941 cgaagccgag gcgctcggcg gcggccgccg cgtcggcgaa ggcggcgatg acgtcgtcga
    21001 ggtccttctg cgtcatggcg cggcccttgg gctcgccgct cagggagatg cccgagggcc
    21061 cgaccggctc ggcgtccggg acgggcccgg cgccctcggt gcgggtgacg cccacgtgcc
    21121 acagctgcgg gatgatcgcg ccgcccgccc ggtgcacgga gtccgcgacg tgtccccagc
    21181 ccgcgagcgc ggcttcgccg tggaaacggg gaacccggtc gctggtcccg gcggactcgt
    21241 ggtcgacgta cgtgccctcg gtgatgatca gcccgacgtc ggcggcggcg cggcgggtgt
    21301 agtagtccgc cacgtcctgc cccggaacgc cgtccgggga gaactgccgg gtcatgggcg
    21361 ccatcgcgat ccggttccgg gcggtgagtc cgcgcaccga gaacggccgg gagagggcac
    21421 tcgcggcacg ggcggtggcg ctcacgccgc ccgccgtcgc cgcgcccgct gtcgtcgcgt
    21481 cttccgtcgt cgtctctgtc acgtcgatgt cctgtccgta gccggggtgt ccacccgggg
    21541 ccaacacgcc cgggcggcgt ggacatcccg gctccggccg cgacgacggt aaagagtggg
    21601 caaagaacgg agtcaccctc cggcggccgg cccggaccgg gtcacccggg ttcgtcggcg
    21661 aacgtcgggg ccagcgccgc ccgcaaccgc cgggcgaact cctccccgcg gccctcgaac
    21721 cgcgggtact ccccggcgaa gtgatgccat tcgacgtagc ccagcccctc gtccagatcc
    21781 tcgcgcccca cccacgtccg cccggtctcc ggccactccc cgcccagccg gaacacctcc
    21841 tggagcaggg cgaacgggag cgggtgccgc tccgcgagca gggtcgcgtc gtagaggtcc
    21901 ttgccctggg cgtacgcgtc gttgatcagc cacatcacct tccaggccag ggacagcgcg
    21961 ggggtggccc cgtacagcac cgcgccggac ggcaggacga tccgctcggg cggctcgggc
    22021 aactgctcgc cgaacacgaa gtccagctgc acccacccgc ccggggtgcc gggagcctcc
    22081 cagggcagca tcatgcggcg gccgggcacc cgctcgtacg tccagatgtc ctcgcacacg
    22141 gccccggcgg cgcggatccg caccccgtgg gctccgcgcg ccgcccgcgc ctcggccgcc
    22201 gccgcgacac cggccagcag ctccggggtc cgctcctcct ccatccgcca cgaggcggga
    22261 gcgaccacga agtccaggtc accgggctcg cgcgcctcct cgccgaacca cagggccatg
    22321 agcgcactcc cgcgcaccac cagcgcctcg gcccacgggg acgcggccac gccgtcctgt
    22381 acggcggcga gcgccgcggc ccgggcccgc tgccaggccc gggttgccgc gggggagggg
    22441 aagacggggt cggtggcgcg gaaggcgttc gggaactgct tgagcgcggg gtcgaagacg
    22501 gtgcgctgca cggcctcgtc gtccatcacc cgcagcatcg tccccggcac ggcgtccagg
    22561 aagcggcgcc gtgcgtccag cccggcggag gggggcacgg ggccggaggc cggcaccacc
    22621 tcgggaaagg gcgggcgctg ttcgctgctc atatcgcttc caaccatcct tcgtccagct
    22681 ccggaccgct gtccaggagc acgtactccc gctccacgtc gaccacttcg taggcgtgcg
    22741 cggccagttc cgcgagcagc gcgtccagcg cgagcgccgc ccgccggtcg cccgtgcggt
    22801 ggcagcgctg ggtgacgaag cgttcctccc ggccgtccgc ccgtacgcgg cgcgcgttcc
    22861 aggagacgtg cgcgccgtgc cggacggcca ccgcgacgag gccggcccga tcgccgtcgc
    22921 tctcttcgag caggagcttc acgtggtgct cgaagtgccg tcggccgtgg ggatgcccct
    22981 cccccacggc atcggcgtcg tcgcgcggca cctccaccgc ccacggcgcg cactcgacct
    23041 tcacgcgcgc cacggcg
//
