LOCUS       NZ_CP021707            10399 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces sp. S063 chromosome, complete genome.
ACCESSION   NZ_CP021707
VERSION     NZ_CP021707.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S063
  ORGANISM  Streptomyces sp. S063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Complete genome sequence of Streptomyces sp. S063, a producer of
            anti-complement compounds and various secondary metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAY-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:19:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,905
            CDSs (total)                      :: 6,817
            Genes (coding)                    :: 6,244
            CDSs (with protein)               :: 6,244
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 574
            CDSs (without protein)            :: 573
            Pseudo Genes (ambiguous residues) :: 0 of 574
            Pseudo Genes (frameshifted)       :: 432 of 574
            Pseudo Genes (incomplete)         :: 192 of 574
            Pseudo Genes (internal stop)      :: 13 of 574
            Pseudo Genes (multiple problems)  :: 61 of 574
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:16:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1366735
            Orig. end                         :: 1377134
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021707.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Xinqing Zhao, Life Science
            and Biotechnology, Shanghai Jiaotong University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="9"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5399
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    complement(129..142)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.79"
                     /tool="antismash"
     misc_feature    complement(142..157)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.67"
                     /tool="antismash"
     gene            complement(295..1371)
                     /locus_tag="CCZ36_RS06115"
     CDS             complement(295..1371)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512211.1"
                     /locus_tag="CCZ36_RS06115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidohydrolase family protein"
                     /protein_id="WP_128819405.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 2.1e-16, bitscore:
                     58.7, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRVKGRVLVGPDEVRDELWAVDGRITFERPPGADDAVTVRGWVL
                     PGLVDAHCHVGLDRHGPVDAATAEKQALTDREAGTLLIRDAGSPSDTRWIDDREDLPKI
                     IRAGRHIARTRRYIRNYAHEIEPGDLVAYVAQEARRGDGWVKLVGDWIDRDAGDLTACW
                     PRGEVEAAIAEAHRLGARVTAHCFAEESLRDLVETGIDCVEHATGLTEDTIPLFAERGV
                     AIVPTLVNIATFPDLAAGGEAKFPRWSAHMRQLYDRRYDTVRSAYDAGIPVYVGTDAGG
                     SLAHGLVAGEVAELVKAGIPPLEALSATAWGARRWLGRPGLDEGAPADLVVYDADPRAD
                     VRVLAAPRHIVLNGRVIG"
     gene            1520..2626
                     /locus_tag="CCZ36_RS06120"
     CDS             1520..2626
                     /NRPS_PKS="Domain: Aminotran_5 (19-283). E-value: 4.4e-27.
                     Score: 86.8. Matches aSDomain:
                     nrpspksdomains_CCZ36_RS06120_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123620.1"
                     /locus_tag="CCZ36_RS06120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_128817167.1"
                     /sec_met_domain="Aminotran_5 (E-value: 2.6e-20, bitscore:
                     71.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPFLDLPPLTAGHFAAIERRVARLLATEQDVVITQGEALLPLE
                     GCIRGGARPGSTALNVVTGPYGQTFGNWLRDCGAQVVDLAVPFHTAVTADQVAEALAGH
                     PEIDFVSLVHAEAATGNTNPVAEIGEVVGAHGALFMLDAVASVGAEPLLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSARAWERIAANPAAPRRSYLSLLDWKERWIDGGRTALPHAP
                     AQLEMLGLEACVARIEDEGLETVMARHASAAAATRAGAVALGGGLEPYVHEARDAAPVA
                     TTLRAPAGTDAAALVAAALATDPALPLVAGGGALSKEMIRVNHYGADATRGVVLSSLAA
                     LGAALADGGQQVDIEAARRAVSETWSSR"
     aSDomain        1577..2368
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CCZ36_RS06120_Aminotran_5.1"
                     /evalue="4.40E-27"
                     /label="CCZ36_RS06120_Aminotran_5.1"
                     /locus_tag="CCZ36_RS06120"
                     /protein_end="283"
                     /protein_start="19"
                     /score="86.8"
                     /tool="antismash"
                     /translation="ERRVARLLATEQDVVITQGEALLPLEGCIRGGARPGSTALNVVTG
                     PYGQTFGNWLRDCGAQVVDLAVPFHTAVTADQVAEALAGHPEIDFVSLVHAEAATGNTN
                     PVAEIGEVVGAHGALFMLDAVASVGAEPLLPDAWGVDLCVIGAQKAMGGPAGVSAVSVS
                     ARAWERIAANPAAPRRSYLSLLDWKERWIDGGRTALPHAPAQLEMLGLEACVARIEDEG
                     LETVMARHASAAAATRAGAVALGGGLEPYVHEARDAAPVATT"
     misc_feature    complement(2650..2663)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.49"
                     /tool="antismash"
     misc_feature    2754..2771
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.75"
                     /tool="antismash"
     misc_feature    2766..2781
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    2868..2883
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.74"
                     /tool="antismash"
     misc_feature    2900..2912
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    complement(2912..2926)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.51"
                     /tool="antismash"
     gene            2937..3467
                     /gene="ectA"
                     /locus_tag="CCZ36_RS06125"
     CDS             2937..3467
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123622.1"
                     /locus_tag="CCZ36_RS06125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_079134193.1"
                     /transl_table=11
                     /translation="MTAAPADLARARSEFLSIDAPRVEDGAAIWRIARDSQVLDLNSSY
                     SYLLWCRDFAATSVVARGESGEPIAFVTGYIRPDRPQTLVVWQVAVDAAHRGKGLAATL
                     LDALTARVAADQGLSSVETTITPDNTASDRLFTSYAQRHDVALEQEVLFDVDLFPEGTH
                     LPEVLYRIGPFAT"
     gene            3649..4911
                     /gene="ectB"
                     /locus_tag="CCZ36_RS06130"
     CDS             3649..4911
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-363). E-value: 6.6e-72.
                     Score: 234.3. Matches aSDomain:
                     nrpspksdomains_CCZ36_RS06130_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156968.1"
                     /locus_tag="CCZ36_RS06130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_069739472.1"
                     /sec_met_domain="Aminotran_3 (E-value: 4e-76, bitscore:
                     254.9, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITPPALSVFETLESEVRSYCRGWPAVFDRAQGARLTDEDGHSY
                     LDFFAGAGSLNYGHNNPVLKRALIDYIERDGITHGLDMATTAKRAFLETFQNAILRPRD
                     LPYKVMFPGPTGTNAVEAALKLARKVKGRESVVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFDGTVPDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARA
                     EWLRALKELCERQDMLLIVDDIQMGCGRTGGFFSFEEAGIVPDIVTLSKSISGYGLPMA
                     LCLFKPELDIWEPGEHNGTFRGNNPAFVTAAAALQAYWADGQMEKQTLARGEQVEQTLL
                     AICAEEPTAQFRGRGLVWGMEFEDPARASAVCARAFELGLLLETSGPQSEVVKLLPPLT
                     ITPEELDEGLRTLARSVRETA"
     aSDomain        3733..4737
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CCZ36_RS06130_Aminotran_3.1"
                     /evalue="6.60E-72"
                     /label="CCZ36_RS06130_Aminotran_3.1"
                     /locus_tag="CCZ36_RS06130"
                     /protein_end="363"
                     /protein_start="28"
                     /score="234.3"
                     /tool="antismash"
                     /translation="FDRAQGARLTDEDGHSYLDFFAGAGSLNYGHNNPVLKRALIDYIE
                     RDGITHGLDMATTAKRAFLETFQNAILRPRDLPYKVMFPGPTGTNAVEAALKLARKVKG
                     RESVVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVPDFLWFER
                     LLEDQGSGLNKPAAVIVETVQGEGGINVARAEWLRALKELCERQDMLLIVDDIQMGCGR
                     TGGFFSFEEAGIVPDIVTLSKSISGYGLPMALCLFKPELDIWEPGEHNGTFRGNNPAFV
                     TAAAALQAYWADGQMEKQTLARGEQVEQTLLAICAEEPTAQFRGRGLVWGMEFE"
     gene            5001..5399
                     /locus_tag="CCZ36_RS06135"
     CDS             5001..5399
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123624.1"
                     /locus_tag="CCZ36_RS06135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine synthase"
                     /protein_id="WP_006123624.1"
                     /sec_met_domain="ectoine_synt (E-value: 1.2e-53, bitscore:
                     178.9, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFSDIENTDRHVKAASGTWESKRIVLAKEKVGFSLHETVLY
                     AGTETSMWYANHIEAVLCTEGEAELTNDETGEKHWITPGTMYLLDGHERHTMRPKTDFR
                     CVCVFNPPVTGREDHDENGVYPLLTEEG"
     gene            5403..6296
                     /gene="thpD"
                     /locus_tag="CCZ36_RS06140"
     CDS             5403..6296
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156966.1"
                     /locus_tag="CCZ36_RS06140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine hydroxylase"
                     /protein_id="WP_069739473.1"
                     /sec_met_domain="PhyH (E-value: 2.7e-38, bitscore: 131.0,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEVRADLYPSRGAAEMTTPRQDPVIWSAPGAPGPIAAKDLQSY
                     EHDGFLSIEQLITPDEVAVYRAELDRLVADPLIRADERSIVEKQSQNVRSVFEVHKISE
                     VFAGLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPNM
                     RTVSVSIALTENFDTNGGLMIMPGSHKTFLGCAGETPKDNYKKSLQMQDAGTPSDEALT
                     KMADRHGIKLFTGKAGSATWFDCNAMHGSGDNITPYARSNVFIVFNSVENAAQEPFAAP
                     IRRPEFIGARDFTPVR"
     gene            6444..7478
                     /locus_tag="CCZ36_RS06145"
     CDS             6444..7478
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070337.1"
                     /locus_tag="CCZ36_RS06145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_128817168.1"
                     /transl_table=11
                     /translation="MTSHVRHITIDCADAYALAAFWAQVLGAPLSDEDSPGDPEALVEA
                     PGAAILFVQVDEPKQTKNRVHLDIQPDDRSRDEEVERLLALGATLVADHRKPNGRGWAT
                     LADPEGNEFCVECGAAERAALTGTRLPVTADDVTTAVRLAVDVLAKAPADRWEARAGSL
                     EWTCWETAEHLGDDLVSYAVRLGPRTPPMEQNLPFRWTSERPGGHDGLLFVDRSAGPAG
                     LLATVEARGALLASMVRTTPPEVRAYHVYSVSDPEGFAAMGVVETLVHAHDIAEGLGLT
                     WEPPAALCDRALARLFPDAPAGGDRWAVLLWATGRAELPGHPRRTAWRWDGRPLEDQTA
                     SSAG"
     gene            complement(7454..8524)
                     /locus_tag="CCZ36_RS06150"
     CDS             complement(7454..8524)
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969934.1"
                     /locus_tag="CCZ36_RS06150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alkene reductase"
                     /protein_id="WP_128817169.1"
                     /transl_table=11
                     /translation="MTTVFDPIDLSGTPLANRIALAPMTRSRAGEGGTATELTATYYAQ
                     RASAGLIITEGIQPSVVGQGYPSTPGLHSAEQVASWRAVTDAVHAKGGRIFAQIMHAGR
                     IGHPVLLPDGLVPVSASPVKAEGQVYTHVGPKDFVEPHELTDAEVRATVADFVTAARNA
                     VAAGFDGVELHGANGYLIHQFLAPNTNRRTDAWGGSDEARTRFAVEVVEAVAAEIGPER
                     TGLRISPGNPYNDIDEPAPEATYTALVRAIEPLGLAYLHILEATPIRELTLALRKAFSG
                     TVVINVHSDGPTGPGDHTVIDDGIADLISYGALFLANPDLPARLRAGGPFNTPDPSTFF
                     GGDAKGYTDYPALDAV"
     misc_feature    complement(8509..8523)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.18"
                     /tool="antismash"
     gene            8701..9222
                     /locus_tag="CCZ36_RS06155"
     CDS             8701..9222
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123628.1"
                     /locus_tag="CCZ36_RS06155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_069739476.1"
                     /transl_table=11
                     /translation="MTTGRATPAEDACTNAPPLAALGGPVSHAVSRVARLHRIAAGKAL
                     RGVDLYPGQELLMMHLWDRGAVRQTELIRALELDPSTVTKMLQRLEQTGHVRRRPDPAD
                     RRAVLVEATDESCALHTAVEAAWGSLEEHTLAGLDPAERTELVRLLAKVEENLCRETED
                     CPDRRGAASA"
     gene            complement(9259..10317)
                     /locus_tag="CCZ36_RS06160"
     CDS             complement(9259..10317)
                     /NRPS_PKS="Domain: Aminotran_5 (19-347). E-value: 1.5e-23.
                     Score: 75.2. Matches aSDomain:
                     nrpspksdomains_CCZ36_RS06160_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070339.1"
                     /locus_tag="CCZ36_RS06160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_069739477.1"
                     /sec_met_domain="Aminotran_5 (E-value: 7.9e-17, bitscore:
                     59.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTILAPIQAAAVEFAPEVTYLNTSSWGLLPRRTIAAVKALADENA
                     AGRRVGAGSFEAVEAARAGFARLVGVHPDRVATGSSVTVHVGLIAASLPPGAEVLCPEG
                     EFSSVVSPFALRGDLRMRYAPLADLAGAVRASTALVAFSAVQSADGRVADLAAVRAAAS
                     AHGARTLLDATQAAGWFPVDAGAYDYTVTGGFKFLLCPRGTSFLTVTEEAQDTLPALFA
                     GWVSAGAPWTNNYGPLERLAPTARGFDEPPAFLSYHGAEHSLALLAEVGAEALYAHATG
                     LAARLRTGLAALGHKAVPGESAIVAVPGLDGRQPELVEAGIAVSAPAGNLRISCHLHNT
                     EADVDRLLDFLA"
     aSDomain        complement(9277..10260)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CCZ36_RS06160_Aminotran_5.1"
                     /evalue="1.50E-23"
                     /label="CCZ36_RS06160_Aminotran_5.1"
                     /locus_tag="CCZ36_RS06160"
                     /protein_end="347"
                     /protein_start="19"
                     /score="75.2"
                     /tool="antismash"
                     /translation="YLNTSSWGLLPRRTIAAVKALADENAAGRRVGAGSFEAVEAARAG
                     FARLVGVHPDRVATGSSVTVHVGLIAASLPPGAEVLCPEGEFSSVVSPFALRGDLRMRY
                     APLADLAGAVRASTALVAFSAVQSADGRVADLAAVRAAASAHGARTLLDATQAAGWFPV
                     DAGAYDYTVTGGFKFLLCPRGTSFLTVTEEAQDTLPALFAGWVSAGAPWTNNYGPLERL
                     APTARGFDEPPAFLSYHGAEHSLALLAEVGAEALYAHATGLAARLRTGLAALGHKAVPG
                     ESAIVAVPGLDGRQPELVEAGIAVSAPAGNLRISCHLHNTEADVDRL"
ORIGIN
        1 gaacccccac aagagacatg gagccaccgg cacagtccaa tgggggacat cgcccggccg
       61 gtgacctcga ctccgtgaat ctttacgcac tgagggtgaa ctggcggata cctgacgtga
      121 gttcacccca aagggaggtt tccgcgcata cattcgaatc tttcggcacg tgcgttccct
      181 cccgcccctc cccgtcaccc gtttcgcgcg gaaggggccg cggcgcgtgg acgggccggc
      241 catgtcaacg agccgggggc cgcattcgtc actgcccgtc aacgcaccgc cgactcagcc
      301 gatgacccgc ccgttcagca cgatgtgccg gggcgccgcc agcacccgga cgtccgcgcg
      361 ggggtccgcg tcgtacacga ccaggtccgc cggagccccc tcgtcgaggc cgggccgccc
      421 cagccagcgc ctggctcccc acgcggtcgc ggagagggcc tccagcggcg ggatgcccgc
      481 cttcaccagc tcggccacct cccccgcgac caggccgtgc gccagggagc cgcccgcgtc
      541 ggtgccgacg tagaccggga tcccggcgtc gtacgcggag cgcacggtgt cgtagcggcg
      601 gtcgtacagc tgccgcatat gggccgacca gcgggggaac ttggcctcgc cgcccgccgc
      661 caggtcgggg aaggtggcga tgttgaccag cgtcgggacg atcgcgacgc cgcgttcggc
      721 gaagagcggg atggtgtcct cggtgaggcc ggtggcgtgc tcgacgcagt cgatgcccgt
      781 ctccaccaga tcgcgcaggg actcctcggc gaagcagtgc gcggtgaccc gggcacccag
      841 ccggtgcgcc tcggcgatgg ccgcctcgac ctcgccgcgc ggccagcagg cggtgaggtc
      901 cccggcgtcg cggtcgatcc agtcccccac cagcttgacc cagccgtcgc cgcgccgggc
      961 ctcctgggcg acgtacgcga cgaggtcgcc gggctcgatc tcgtgcgcgt agttgcggat
     1021 gtagcggcgg gtcctggcga tgtggcggcc ggccctgatg atcttcggca gatcctcgcg
     1081 gtcgtcgatc cagcgggtgt cggagggcga tccggcgtcg cggatcagca gggtcccggc
     1141 ctcccggtcg gtgagcgcct gcttctcggc ggtcgccgcg tcgaccgggc cgtgccggtc
     1201 gagccctaca tggcagtggg cgtcgacgag gccgggcagc acccagcccc tgaccgtcac
     1261 cgcgtcgtcc gcgccgggcg gccgctcgaa ggtgatccgt ccgtccaccg cccacagttc
     1321 gtcccgcacc tcgtccgggc cgacgagcac ccggcccttc acccgcagca ccggccgctc
     1381 cttgcgatca ctcactccga ccacccgtcc gaccgctcac ccgatcactc atacgccgca
     1441 ctgtacgagg ccgccggtgg gccgtcggta ggctgccagt gccttccgac cgacggacga
     1501 acccgaagag agcaccaccg tgacgcaccc cttcctcgac cttcccccgc tgaccgccgg
     1561 ccacttcgcg gcgatcgagc gacgtgtggc ccggctcctc gccacggagc aggacgtcgt
     1621 catcacccag ggcgaggcgc tgctgccgct ggagggctgc atccgcggcg gcgcccggcc
     1681 cggctcgacc gcgctgaacg tggtcacggg tccgtacggg cagaccttcg gcaactggct
     1741 gcgggactgc ggcgcccagg tcgtcgacct cgcggtgccc ttccacacgg cggtgaccgc
     1801 cgaccaggtc gccgaggcgc tggccgggca cccggagatc gacttcgtct cgctggtgca
     1861 cgcggaggcg gcgaccggca acaccaaccc ggtcgcggag atcggcgagg tggtcggggc
     1921 gcacggggcg ctgttcatgc tggacgcggt cgcctcggtg ggcgccgaac cgctgctgcc
     1981 ggacgcctgg ggcgtcgacc tgtgcgtgat cggcgcgcag aaggccatgg gcgggcccgc
     2041 cggggtctcc gcggtgtcgg tgagcgcgcg ggcctgggag cggatcgccg ccaacccggc
     2101 cgccccgcgc cgctcctacc tctcgctgct ggactggaag gaacgctgga tcgacggcgg
     2161 ccgcacggcc ctgccgcacg ccccggcgca gctggagatg ctgggtctgg aggcgtgtgt
     2221 ggcccggatc gaggacgagg gcctggagac ggtgatggcc cgccacgcct cggccgccgc
     2281 ggcgacccgg gcgggagcgg tggcgctggg cggcggtctg gagccgtacg tccacgaggc
     2341 acgggacgcg gccccggtgg cgacgacgct gcgtgccccg gcggggacgg acgcggccgc
     2401 gctggtcgcg gcggcactgg cgacggaccc cgcgctgccg ctggtcgcgg gcggcggggc
     2461 gctgtccaag gagatgatcc gggtcaacca ttacggggcg gatgcgacgc ggggcgtggt
     2521 gctgtcctcg ctcgcggctc tgggggcggc gctggccgat gggggccagc aggtcgatat
     2581 cgaggctgcc cgccgggccg tttcggaaac ctggtcgagc cgctgattta gccaccatgc
     2641 ggggagctgc tttattgaaa gcagctcccc gcattctttt gcccgcttct ccgtcgccta
     2701 aacgcggaag ttttcgcggg gctcgaactt catgtttcgg acacgctcca ggagagttat
     2761 gagcctgtga ccgactccac acgagcggcg ttatgcccgt taaattcagg acaaagcggt
     2821 ggaagttcca tcccgatcat ggggcggctc gcgcacgcct gataacacac acaatctctt
     2881 cacccaaccc ctcacgtcga tgcaatttcg aaatttgctg ggtaaattca attcgcatga
     2941 ccgccgcacc agcagatctt gcccgtgccc gaagtgaatt cctcagtatc gatgcgccgc
     3001 gagtggagga cggagccgcg atctggcgca tagcccgcga ctcccaggtc ctggacctga
     3061 actcctcgta cagctacctg ctgtggtgcc gtgacttcgc cgcgacctcc gtcgtcgccc
     3121 gtggcgagag cggcgagccc atcgccttcg tgacgggcta catccggccc gaccgccccc
     3181 agaccctcgt cgtctggcag gtggccgtcg acgcggccca ccgcggcaag ggactggccg
     3241 ccacgctgct ggacgcgctg accgcccggg tcgccgccga ccagggcctg tcgtccgtcg
     3301 agacgacgat caccccggac aacaccgcct ccgaccggct gttcacgtcc tacgcccagc
     3361 ggcacgacgt ggcgctggag caggaggtcc tcttcgacgt cgacctgttc cccgaaggga
     3421 cccacctgcc cgaggtcctc taccggatcg gcccgttcgc cacctgagcc cgcccgggcg
     3481 cgccctcggc gccccggccc gtacgcccgc cgcccggcgc accccacccg tgcgcccggc
     3541 ccccgacttt tcgcgccggc cgaccacccg gcgcggtccc ggccgcatcc gtgcggccgg
     3601 gagcacgaga ccaccgcccg tcacaccccc tcacgcagga gatccgctgt gaccatcacc
     3661 ccgcccgcac tgagtgtctt cgagaccctg gagtccgagg tccggagcta ctgccgcggc
     3721 tggcccgccg tcttcgaccg tgcgcagggc gcccggctga ccgacgagga cggccactcc
     3781 tacctggact tcttcgccgg ggccggctcg ctcaactacg gccacaacaa cccggtgctg
     3841 aaacgagcgc tgatcgacta catcgagcgc gacggcatca cccacggcct ggacatggcg
     3901 accaccgcca agcgcgcgtt cctggagacg ttccagaacg cgatcctgcg cccgcgcgac
     3961 ctgccgtaca aggtgatgtt ccccggcccg accggcacca acgccgtcga ggcggcgctg
     4021 aagctggccc gtaaggtcaa gggccgcgag tccgtcgtct cgttcaccaa cgccttccac
     4081 ggcatgtcgc tgggctcgct cgccgtcacg ggcaacgcct tcaagcgcgc cggggccggg
     4141 atcccgctgg tgcacggcac tccgatgccg ttcgacaact acttcgacgg tacggtcccc
     4201 gacttcctgt ggttcgagcg gctgctggag gaccagggct ccgggctgaa caagcccgcc
     4261 gcggtgatcg tcgagacggt ccagggcgag ggcggcatca acgtcgcccg cgccgagtgg
     4321 ctgcgcgcgc tcaaggagct gtgcgagcgc caggacatgc tgctgatcgt cgacgacatc
     4381 cagatgggct gcggccggac cggcggcttc ttctccttcg aggaggccgg catcgtcccg
     4441 gacatcgtca cgctgtcgaa gtccatcagc ggctacgggc tgccgatggc gctctgcctg
     4501 ttcaagccgg agctggacat ctgggagccg ggcgagcaca acggcacctt ccgcggcaac
     4561 aacccggcct tcgtcacggc cgccgccgcg ctccaggcgt actgggcgga cggccagatg
     4621 gagaagcaga ccctggcccg cggcgagcag gtcgagcaga cgctgctggc catctgcgcc
     4681 gaggagccga ccgctcagtt ccgcggccgg ggcctggtgt ggggcatgga gttcgaggac
     4741 ccggcgcggg cctcggcggt ctgcgcccgc gccttcgagc tggggctcct gctggagacc
     4801 tccggcccgc agagcgaggt cgtcaagctg ctgccgccgc tgaccatcac ccccgaggaa
     4861 ctggacgagg ggctgcgcac actggcccgc tccgtccgcg agacggcctg acccggaacc
     4921 gccggggcag gtggaagaag agaggccccg ggccgcgacg cccggggccc gtgcagagaa
     4981 gagaaaggca accgctcacc gtgatcgtcc gatcgttcag tgacatcgag aacaccgacc
     5041 ggcatgtgaa ggccgcgtcc ggcacctggg agagcaagcg catcgtgctc gccaaggaga
     5101 aggtgggctt ctcgctccac gagaccgtgc tgtacgcggg cacggagacc tccatgtggt
     5161 acgcgaacca catcgaggcg gtgctgtgca ccgagggcga ggccgagctc accaacgacg
     5221 agaccggcga gaagcactgg atcacgcccg gcacgatgta tctgctggac ggacatgagc
     5281 ggcacaccat gcggcccaag accgacttcc gctgcgtgtg cgtcttcaat ccccccgtca
     5341 ccggacggga ggaccatgac gagaacggtg tctacccact gctgaccgag gagggctgaa
     5401 ccatgaccac cgaagtacgc gccgatctgt acccctcgcg cggcgccgcc gagatgacca
     5461 ctccccgcca ggacccggtc atctggtccg cgccgggcgc accgggtccg atcgccgcca
     5521 aggacctcca gagctacgag cacgacggct tcctcagcat cgagcagctg atcacgccgg
     5581 acgaagtcgc cgtctaccgg gcggagctgg accggctggt cgccgacccg ctgatccgtg
     5641 ccgacgagcg ctccatcgtg gagaagcagt cgcagaacgt gcggtccgtc ttcgaggtcc
     5701 acaagatcag tgaggtcttc gccggtctgg tccgcgacga gcgggtggtg ggccgggccc
     5761 gccagatcct cggctcggac gtgtacgtcc accagtcgcg gatcaacgtg aagccgggct
     5821 tcggggcctc gggcttctac tggcactcgg acttcgagac gtggcacgcg gaggacggtc
     5881 tgccgaacat gcggacggtg tccgtgtcga tcgcgctgac ggagaacttc gacaccaacg
     5941 gcgggctgat gatcatgccc ggttcgcaca agacgttcct cggctgtgcg ggcgagacgc
     6001 cgaaggacaa ctacaagaag tcgctccaga tgcaggacgc cggcaccccg tccgacgagg
     6061 cgctgacgaa gatggccgac cgccacggca tcaagctctt cacgggcaag gccggttcgg
     6121 cgacctggtt cgactgcaac gccatgcacg gttcgggcga caacatcacc ccgtacgcgc
     6181 gcagcaacgt cttcatcgtc ttcaacagcg tggagaacgc ggcgcaggag cccttcgcgg
     6241 ctccgatccg ccgcccggag ttcatcgggg cgcgggactt caccccggtg aggtagcgcg
     6301 acgcgcaggc ggcaagggcc gggacggtgc gccgtcccgg cccttcgcgt gtgccgccgg
     6361 gaccggggcg cggggggcaa gccggcccgg tcgccgggta actcactgga ccgggacccg
     6421 agtcggcggg gagggtgtcc gccatgactt cccatgtacg ccacatcacg atcgactgcg
     6481 ccgacgccta cgcgctggcc gccttctggg cccaggtgct cggtgcgccg ctctccgacg
     6541 aggactcccc cggtgatccg gaggcgctgg tcgaggcgcc cggcgcggcg atcctcttcg
     6601 tacaggtgga cgagccgaaa cagaccaaga accgcgtcca tctcgacatc cagccggacg
     6661 accgctcccg cgacgaggag gtcgagcggc tgctcgcgct cggcgcgacc ctcgtcgccg
     6721 accaccgcaa accgaacggg cgcggctggg cgacgctcgc cgatcccgag ggcaacgagt
     6781 tctgcgtgga gtgcggcgcg gccgagcggg cggcgctgac cgggacccgg ctgccggtga
     6841 ccgccgacga cgtgacgacc gccgtgcggc tcgcggtgga cgtgctggcg aaggccccgg
     6901 cggaccgctg ggaggccagg gccggttcgc tggagtggac ctgctgggag acggcggagc
     6961 acctgggcga cgatctcgtc tcgtacgccg tgcgcttggg cccgcgtacg cccccgatgg
     7021 agcagaacct ccccttccgg tggacctccg aacgcccggg cggccacgac ggcctgctct
     7081 tcgtcgaccg ctcggccggg cccgccgggc tgctggcgac ggtggaggcg cgcggggcgc
     7141 tgctggcctc gatggtgcgg acgacgccgc cggaggtgcg cgcgtaccac gtctacagcg
     7201 tctcggaccc ggagggcttc gccgcgatgg gggtggtgga gaccctggtg cacgcccatg
     7261 acatcgcgga ggggctgggg ctgacgtggg agccgcccgc cgcgctctgc gaccgggcgc
     7321 tggcccggct cttcccggac gctccggcgg gcggcgaccg gtgggccgtc ctgctgtggg
     7381 ccaccggccg cgccgaactg ccgggccacc cgcgccgcac cgcgtggcgg tgggacgggc
     7441 ggcccctgga ggatcagacg gcgtcgagcg ccggatagtc ggtgtagccc ttggcgtcgc
     7501 cgccgaagaa ggtcgacggg tcgggggtgt tgaacgggcc gcccgccctc agccgggcgg
     7561 gcaggtccgg gttggcgagg aagagtgccc cgtaggagat caggtcggcg atgccgtcgt
     7621 cgatcaccgt gtggtcgccg gggccggtgg gtccgtcgga gtgcacgttg atgacgacgg
     7681 tcccggagaa ggccttgcgc agggcgaggg tcagctcgcg gatcggggtg gcctccagga
     7741 tgtgcagata ggcgaggccg agcggctcga tcgcccggac cagcgcggtg tacgtggcct
     7801 ccggcgcggg ctcgtcgatg tcgttgtacg ggttgccggg cgagatgcgc agtccggtgc
     7861 gctccgggcc gatctcggcg gcgacggcct cgacgacctc cacggcgaag cgggtgcggg
     7921 cctcgtcgga gccgccccac gcgtcggtgc gccggttggt gttgggggcg aggaactggt
     7981 ggatgaggta gccgttggcg ccgtgcagct cgaccccgtc gaacccggcc gccacggcgt
     8041 tgcgggcggc ggtgacgaag tcggcgacgg tcgcgcggac ctccgcgtcg gtcagctcgt
     8101 gcggctcgac gaagtccttc ggcccgacgt gggtgtagac ctgcccctcg gccttgaccg
     8161 gggaggcgct gacggggacg agcccgtccg gcagcaggac cgggtggcca atacggcccg
     8221 cgtgcatgat ctgggcgaag atcctgccgc ccttcgcgtg caccgcgtcg gtgaccgcac
     8281 gccaggaggc gacctgctcg gcgctgtgca ggccgggcgt ggaggggtag ccctggccca
     8341 cgacggacgg ctggatgccc tcggtgatga tgagtcccgc cgaggcgcgc tgggcgtagt
     8401 acgtggcggt cagctcggtg gcggtgccgc cctcaccggc ccggctgcgg gtcatcgggg
     8461 ccagcgcgat gcggttggcc agcggggtgc cggacaggtc gatcgggtcg aaaacggtgg
     8521 tcatgagggg ctcccggata agtatgtggt cggccaacca tcgccgccgg gagtaactgt
     8581 aacccattcc ttggccgacc aaggtaaagt tgtccggaac cgtcgggcat catcggaagc
     8641 cgccaccgag gccatcaccg aaaccgtcgc tctccacccc gacgacccca ggagcccgcc
     8701 atgaccaccg gccgcgccac ccccgcggaa gacgcctgta cgaacgcgcc gcccctggcg
     8761 gcgctcggcg ggcccgtcag ccacgccgtc tcccgggtgg cccggctgca ccggatcgca
     8821 gcgggcaagg cgctcagggg cgtggacctc tacccggggc aggagttgct gatgatgcac
     8881 ctgtgggacc ggggggcggt ccggcagacg gagctgatca gggccctgga gctggacccg
     8941 tccacggtca cgaagatgct ccagcggctg gagcagaccg ggcatgtgcg ccgccgcccc
     9001 gacccggccg accggcgggc cgtgctggtc gaggcgacgg acgagagctg cgcgctgcac
     9061 accgcggtgg aggccgcctg gggcagcctg gaggagcaca cgctcgcggg cctggacccg
     9121 gccgagcgca cggagctggt gcggctgctg gcgaaggtcg aggagaacct ctgccgggag
     9181 accgaggact gccccgaccg gcgcggggcc gcgtccgcct gagccgtacg gcccgagcca
     9241 cgcccgtgcg gatacggctc aggccaggaa gtccagcagc cggtccacat cggcctcggt
     9301 gttgtggagg tggcaggaga tccgcaggtt cccggccggg gcggagaccg cgatcccggc
     9361 ctccaccagc tcgggctgac gcccgtcgag ccccggcacg gcgacgatcg ccgactcccc
     9421 gggaacggcc ttgtgcccga gggccgccag ccccgtccgc agccgggcgg cgagcccggt
     9481 ggcgtgcgcg tacagggcct cggcgccgac ctcggcgagc agggcgaggg agtgctcggc
     9541 cccgtggtac gagaggaagg cgggcggctc gtcgaagccg cgggcggtgg gggccaagcg
     9601 ctccagcggg ccgtagttgt tcgtccaggg ggcacccgcg gagacccagc ccgcgaagag
     9661 ggccggcagg gtgtcctgcg cctcctcggt gacggtcagg aacgacgtac cgcgcgggca
     9721 gagcaggaat ttgaagccgc cggtcacggt gtagtcgtac gccccggcgt ccaccgggaa
     9781 ccagcccgcc gcctgggtgg cgtccagcag ggtgcgggcc ccgtgcgccg aggcggccgc
     9841 gcggacggcg gcgaggtcgg cgacccggcc gtcggccgac tgcacggcgg agaaggcgac
     9901 cagcgcggtc gatgcgcgga cggccccggc gaggtccgcg agcggcgcgt accgcatgcg
     9961 cagatcgccg cggagcgcga acgggctgac gacggaggag aactcgccct cggggcagag
    10021 gacttcagca ccgggcggca gcgaggcagc gatcaggccg acgtggacgg tgacggagct
    10081 gccggtggcg acccggtccg ggtggacccc gacgagccgc gcgaagccgg cccgggcggc
    10141 ctccacggcc tcgaagctgc cggcccccac ccggcggccc gcggcgttct cgtcggccag
    10201 ggccttgacg gcggcgatcg tccggcgggg cagcaggccc cagctggagg tgttgaggta
    10261 ggtgacctcg ggcgcgaatt cgacggctgc ggcttggatg ggcgcgagga tcgtcatgcg
    10321 tccaccctgg agccccctcg acccaaagtc aattacagag agttaagggg aactccaaag
    10381 aagcgcttat ggatcgcga
//
