LOCUS       NZ_CP021707            21076 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces sp. S063 chromosome, complete genome.
ACCESSION   NZ_CP021707
VERSION     NZ_CP021707.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S063
  ORGANISM  Streptomyces sp. S063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Complete genome sequence of Streptomyces sp. S063, a producer of
            anti-complement compounds and various secondary metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAY-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:19:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,905
            CDSs (total)                      :: 6,817
            Genes (coding)                    :: 6,244
            CDSs (with protein)               :: 6,244
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 574
            CDSs (without protein)            :: 573
            Pseudo Genes (ambiguous residues) :: 0 of 574
            Pseudo Genes (frameshifted)       :: 432 of 574
            Pseudo Genes (incomplete)         :: 192 of 574
            Pseudo Genes (internal stop)      :: 13 of 574
            Pseudo Genes (multiple problems)  :: 61 of 574
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:16:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 883680
            Orig. end                         :: 904756
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021707.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Xinqing Zhao, Life Science
            and Biotechnology, Shanghai Jiaotong University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21076
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="7"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21076
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21076
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11076](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11076
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(249..262)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.84"
                     /tool="antismash"
     misc_feature    complement(930..943)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
     gene            complement(1271..2479)
                     /locus_tag="CCZ36_RS03925"
     CDS             complement(1271..2479)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070136.1"
                     /locus_tag="CCZ36_RS03925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 6 protein"
                     /protein_id="WP_128817034.1"
                     /transl_table=11
                     /translation="MPGTRVRRRTAHRERRRAARRHALLAVASAVVAIGATAGLIDAGH
                     RDGRDTARPGPTAPPVLGPLPGVPTPTPTAPAPSTPSARPVPAPAPSRTTSRPSAAPEP
                     PSSPSATPAPAPRNRLFRHPHSQVLDWVRAHPDDPRRPVIESRIAARPAAVWFAAHNPG
                     EIAGQVRAVTRGAAAAGRVPVLVPYAIPDRDCGGASKGGAPDLAAYDAWIGEFARGLGA
                     GAAIVILEPDAIALSDCLSASERAARFASLARAGRTLRAAGPRARVYFDGGHSGWHAPA
                     KQAAALRAAGAATDGDGIFTNVANFHRTADETAYARRVLAALGGPPGLGAVVDTSRNGN
                     GAPPAGQWCDPAGRALGQTPTTRTGEARIDAYLWVKLPGESDGCSGAAGSFTPEYAYAL
                     ATG"
     misc_feature    2577..2590
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            2577..3287
                     /locus_tag="CCZ36_RS03930"
     CDS             2577..3287
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123149.1"
                     /locus_tag="CCZ36_RS03930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5995 family protein"
                     /protein_id="WP_128817035.1"
                     /transl_table=11
                     /translation="MTQIEQFAGTAGAGRPPAGASPVIERMREWCSRWPPGEGVAVFNT
                     AYLEVVGRVDPDLGGDGPDDREAAALLAVRCAEAYLSAVETAAAGGRPPECWRPLLPCR
                     RHPGVRPVQFALSALQAHVGHDLVLAVVDTCRTLDCDPPDLEGEFERVGDLLALLEERI
                     HDELMPGPDALGIADPLTHLVSSWSLERAREAAWSAARVLWRLRGFPSLAEEFRQRTDA
                     GAGLVGRLLLTPCR"
     gene            complement(3314..5007)
                     /locus_tag="CCZ36_RS03935"
                     /pseudo=""
     CDS             complement(3314..5007)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671499.1"
                     /locus_tag="CCZ36_RS03935"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTSTVPNAVQHTDAAAPPITMFGPDFPYAYDDFLAHPAGLGQIPA
                     TEHGQEVAVIGGGLSGIIAAYELMKMGLKPVVYEADQIGGRLRTVGFDGCDGDLTAEMG
                     AMRFPPSSTALQHYIDLVGLQTRPFPNPLSPATPSTVVDLKGESHYAETIDDLPQVYRD
                     VAEAWSACLEEGADFSDMNRALRERDVPRIREIWSQLVERLDNQTFYGFLCESEAFRSF
                     RHREIFGQVGFGTGGWDTDFPNSILEILRVVYTEADDHHRGIVGGSQQLPLLLWDREPQ
                     KIVHWPLGTSLSSLHDGEPRGAVTRLTRTAGNRITVTDATGDIRTFRAAVFTGQSWLLL
                     SKIDCDDALFPIDHWTAMERTHYMESSKLFVPVDRPFWLDKDETTGRDTMSMTLTDRMT
                     RGTYLLDDGPDKPAVICLSYTWCDDSLKWLPLSPKERMEVMLKSLGEIYPNVDIRSHII
                     GNPVTVSWENEPWFMGAFKANLPGHYRYQRRLFTHFMQDRLPEDKRGIFLAGDDISWTA
                     GWAEGAVQTALNAVWGVMHQFGGATDATNPGPGDVFDEIARSSFRRT"
     gene            complement(5057..5854)
                     /locus_tag="CCZ36_RS03940"
     CDS             complement(5057..5854)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007453202.1"
                     /locus_tag="CCZ36_RS03940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbon-nitrogen hydrolase family protein"
                     /protein_id="WP_128817036.1"
                     /transl_table=11
                     /translation="MPSLRTALLQSSGRPGAVAENLKTLDEAAARAAGAGARLLVAPEL
                     FLTGYAIGDAVPVLAEPADGPGAEAIAEIAVRHGLAVLYGYPERDGELIFNASQLIAPD
                     GVRLANYRKTHLFGCFEQEWFTPGEQTVVQADIDGIRIGLLICYDVEFPENVRAHALAG
                     TDLLLVPTAQMHPFQFVAESVVPVRAFESQMYVAYVNRTGPEGEFEFVGLSCLAGPDGA
                     VRTRAGRGEELVIGEVDPEFLAASRAANPYLADRRPGLYGSLA"
     gene            complement(6039..6497)
                     /locus_tag="CCZ36_RS03945"
     CDS             complement(6039..6497)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512479.1"
                     /locus_tag="CCZ36_RS03945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_069737316.1"
                     /transl_table=11
                     /translation="MRLNDLDERIVLALAEDARRSYADIGAIVGLSAPAVKRRVDRLRA
                     EGAITGFTVRVDPAALGWETEGFIEIYCSRNTSPEAIKQGLARYPEIASASTVTGDADA
                     VVQVFAADMRHFEQVLERIAGEPYVERTKSVLVLSPLLRRYSAEAPPA"
     misc_feature    6464..6478
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.1"
                     /tool="antismash"
     gene            complement(6614..8071)
                     /locus_tag="CCZ36_RS03950"
     CDS             complement(6614..8071)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015607337.1"
                     /locus_tag="CCZ36_RS03950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_069737317.1"
                     /sec_met_domain="Aldedh (E-value: 3.1e-156, bitscore:
                     519.1, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFFTDLAHQYIDGEWRPGKGSWDIIDFNPFDGEKLASIPVATAD
                     EVDQAYRAAERAQQAWADTNPYSRRAVLEKALGIVEEREQEIGEAIVAELGGTRLKAAF
                     ELHLAKEFLREAIQLALRPAGQILPSPTEGKENRVYRVPVGVVGVISPFNFPFLLSLKS
                     VAPALALGNAVVLKPHQNTPICGGTLLAKVFEDAGLPAGLLNVVITDIAEIGDTLLEHP
                     VPQVISFTGSDKVGRHVATVCAQNLKRAVLELGGNSALIVLDDADVDYAVDAAVFSRYV
                     HQGQVCMAANRILVDRAVEAEFTEKFVAKVASLTVGDPADPATQIGPLINSSQAESVSK
                     LVDQTVAAGATALLHGRADGNLVSPSVLTGLAADSPVLQQEIFGPVALLVPFDGEDEAV
                     RIANDTPYGLSGAVHTGNIERGVRVGQRIHTGMIHINDGTVHDEPIVPFGGEKSSGLGR
                     LNGDSMIEAFTTQKWISIQHGRSQFPF"
     misc_feature    8114..8128
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.86"
                     /tool="antismash"
     gene            complement(8238..9704)
                     /locus_tag="CCZ36_RS03955"
     CDS             complement(8238..9704)
                     /GO_function="GO:0003938 - IMP dehydrogenase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018960551.1"
                     /locus_tag="CCZ36_RS03955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GuaB1 family IMP dehydrogenase-related protein"
                     /protein_id="WP_069737318.1"
                     /transl_table=11
                     /translation="MRFLEPGTGRYTESPAVPYDLTYDDVFMVPGRSAVGSRQGVDLSS
                     PDGTGTTIPLVVANMTAIAGRRMAETVARRGGLVVIPQDIPIEVVTDVISWVKTRHLVL
                     DTPIELAPGQTVADALSLLPKRAHGAGVVVDADRRPVGVVTEHDLSGVDRFTQLSEVMS
                     KDLVLLDADIDPRDAFHKLDGANRKLAPAVDADGRLVGILTRKAALRATLYTPATDAEG
                     KLRIAAAVGINGDVAGKAKQLLDAGADVLVVDTAHGHQESMISAVKAVRALDPQVPIVA
                     GNIVAAEGVRDLIEAGADIIKVGVGPGAMCTTRMMTGVGRPQFSAVLECAAEAKKHGKH
                     VWADGGVRHPRDVAMALAAGASNVMIGSWFAGTYESPGDLQQSADGRFYKESFGMASAR
                     AVKNRTSDESAYDRARKALFEEGISTSRMFLDPARPGVEDLIDSIIAGVRSSCTYAGAG
                     SLAEFAEKAVVGVQSAAGYAEGKPLHASWS"
     misc_feature    9695..9706
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.23"
                     /tool="antismash"
     misc_feature    9704..9718
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.62"
                     /tool="antismash"
     misc_feature    9711..9720
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.15"
                     /tool="antismash"
     misc_feature    9712..9725
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.76"
                     /tool="antismash"
     misc_feature    complement(9713..9726)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.18"
                     /tool="antismash"
     misc_feature    9714..9727
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.15"
                     /tool="antismash"
     misc_feature    9715..9728
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.7"
                     /tool="antismash"
     gene            10001..11076
                     /locus_tag="CCZ36_RS03960"
                     /pseudo=""
     CDS             10001..11076
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018960550.1"
                     /locus_tag="CCZ36_RS03960"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="terpene cyclase"
                     /pseudo=""
                     /sec_met_domain="T1TS (E-value: 1.3e-27, bitscore: 95.9,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSELPDIYCPFPQRTNPHVAHTRDHLDDWTRRTGLVHRESARHR
                     FEQADFGAFVGMVYPTADEEHLDLVADWFVWLFLVDDQLDDGHLGRSPALVRSVVERMR
                     AVVDGSAPSRCRARRSRPP"
     gene            complement(11141..12136)
                     /locus_tag="CCZ36_RS03965"
     CDS             complement(11141..12136)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490194.1"
                     /locus_tag="CCZ36_RS03965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar-binding domain-containing protein"
                     /protein_id="WP_030712649.1"
                     /transl_table=11
                     /translation="MRMGPAELVQAAAMARRFYLEGKSKIQIAEEFGVSRFKVARVLET
                     ALERDLVRIEIRVPAELDAERSDALRARYGLRHAVVVESPAEEQEDAPDPENLGEVAAD
                     LLGELVAEGDVLGLAWGRSTIHMAAALDRLPPCTVVQLTGVYDAGTAERGSVEAVRRAA
                     QVSGGEAHPIYAPMLLPDPATAAALRDQTGIARAFEYFDKVTVAAVSIGSWEPGISTVH
                     DMLSDEERAHYASLGVAAEMSAHLFDAEGRRVGRDLGERCITVEADRLRRIPEVVAIAG
                     GQRKAAAIGAVLRSGLVTSLVTDTAAADYLLTESAAGVRPALERADPDGE"
     gene            complement(12270..12953)
                     /gene="rpe"
                     /locus_tag="CCZ36_RS03970"
     CDS             complement(12270..12953)
                     /EC_number="5.1.3.1"
                     /GO_function="GO:0004750 - D-ribulose-phosphate 3-epimerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rpe"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044795.1"
                     /locus_tag="CCZ36_RS03970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="WP_069737320.1"
                     /transl_table=11
                     /translation="MAQINPSILSADFARLAEEAKAVEGADWLHVDVMDNHFVPNLTLG
                     VPIVEALSKATDTPLDCHLMIEDADRWAPSYVEAGAGSVTFHAEAAAAPVRLAREIRAK
                     GARASMALKPATPIEPYEDLLPELDMLLIMTVEPGFGGQAFLDIMLPKIRRTRELISKH
                     GLELWLQVDGGVSATTIERCAEAGADVFVAGSAVYGAADPAAAVRDLRALADVATAAAP
                     WACDH"
     misc_feature    complement(12940..12953)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     misc_feature    13038..13050
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.37"
                     /tool="antismash"
     misc_feature    complement(13041..13061)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.97"
                     /tool="antismash"
     gene            complement(13102..14535)
                     /locus_tag="CCZ36_RS03975"
     CDS             complement(13102..14535)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512473.1"
                     /locus_tag="CCZ36_RS03975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transcription antitermination factor NusB"
                     /protein_id="WP_069737321.1"
                     /transl_table=11
                     /translation="MNDQPRRRPAKPHRRPKKDPVRFLAFEALRAVDERDAYANLVLPP
                     LLKKARAKGDFDGRDAALATELVYGTLRRQGTYDAIVAACIDRPLREVDPPVLDVLNMG
                     VHQLLGTRIPTHAAVSASVELARVVLGEGRAKFVNAVLRKVTAHDLDGWVEKVAPPYDE
                     DAEEHLAVVHSHPRWIVSALWDALGGGRAGIEDLLEADNERPEVTLAARPGRSTTEELV
                     KALGEDNSLPGRWSPYAVRMAEGGEPGALEAVRESRAGVQDEGSQLVAAALAAVPVEGR
                     DTRWLDGCAGPGGKAALLAALAAERGATLLAAEKQPHRARLVERALAGNPGPYQVITTD
                     GTRPPWLPGTFDRILMDVPCSGLGALRRRPESRWRRRPEDLEAFAPLQRGLLREALKAV
                     RVGGAVAYATCSPHLAETRVVVEDVLKGRGGEPVEAEWVDARPLMPGVSALGEGPDVQL
                     WPHVHGTDAMYLALLRRTG"
     gene            complement(14654..15586)
                     /gene="fmt"
                     /locus_tag="CCZ36_RS03980"
     CDS             complement(14654..15586)
                     /EC_number="2.1.2.9"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004479 - methionyl-tRNA formyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006431 - methionyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="fmt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1228: methionyl-tRNA formyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576375.1"
                     /locus_tag="CCZ36_RS03980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methionyl-tRNA formyltransferase"
                     /protein_id="WP_069737322.1"
                     /transl_table=11
                     /translation="MKLVFAGTPEVAVPALDALIASDRHEVAAVVTRPDAPAGRGRRLV
                     ASPVAERAEEAGIEVLKPARPRDEEFLARLREIAPDCCPVVAYGALLPKAALDVPARGW
                     VNLHFSLLPAWRGAAPVQHSLMAGDEVTGASTFLIEEGLDSGPVYGVLTEEVRPTDTSG
                     DLLTRLAFAGAGLLAATMDGIEDNTLHAVPQPHEGVTLAPKITVEDAQVQWSAPALRVD
                     RVIRGCTPAPGAWTLFRGERLKLIQATPVLDRTDLAPGELSAAKNNVYVGTGSHAVELL
                     WVQPQGKKPMRAADWARGVRIAHGELLGL"
     misc_feature    complement(15571..15585)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.72"
                     /tool="antismash"
     misc_feature    15633..15649
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.87"
                     /tool="antismash"
     gene            15924..16487
                     /locus_tag="CCZ36_RS03985"
     CDS             15924..16487
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010057355.1"
                     /locus_tag="CCZ36_RS03985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_069737323.1"
                     /transl_table=11
                     /translation="MADHATHDAQARASLHLLVRDIERVRRQVDALRTLTAQLGNVYRP
                     RRSGPSAGFVVYGRAPAPTVRLAQELRDSVETLVTAAVDFDRSLGFSWDAVGSALGVTK
                     QAVHRRYGTRRATPQPAAETGGENTAVPRPVSVGTGLTGSSAKSGSPVPSVPAARSMPP
                     QPSAAPQPAREELRPGAFPGPRNG"
     gene            complement(16578..18722)
                     /locus_tag="CCZ36_RS03990"
     CDS             complement(16578..18722)
                     /EC_number="3.6.1.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003678 - DNA helicase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0032508 - DNA duplex unwinding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044799.1"
                     /locus_tag="CCZ36_RS03990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="primosomal protein N'"
                     /protein_id="WP_069737324.1"
                     /transl_table=11
                     /translation="MSSENEQSAEPGAGAPEQLALIRETVRRAKVPRAKPRTWRGAALA
                     EELPVARVLVNKGVLHLDQYFDYAVPQELDADAQPGVRVRVRFGAGGRNVQGGRREGGG
                     LIDGFIVERRADSDYRGALAALASVVSPEPVLGPELLALCRAVADRYAGSLADVLQLAV
                     PPRNGRAEAKPSPDPLPPPPPPDPGTWERYAQGPAFLRALAEGGAPRAVWTALPGPHWP
                     AEIAGAVAATLSSGRGALVVVPDGRSAARVDAALTEALGAGRHALLTAESGPEKRYRQW
                     LAVRRGSVRAVVGTRAAMFAPVRDLGLVVVWDDGDSSHSDDNAPFPHVREVLELRAAQG
                     RCGFLLGGTSCTVEAAQLVESGWALPLLADRERLRRAAPLVRTVGDGELARDGAARSAR
                     LPSLAWGAVRDGLRTGPVLIQVPRRGYAPRLACERCRTPARCRHCAGPLEAPDQQDLNC
                     AWCGQAERAWQCPECGSTRLRARIVGARRTAEELGRAFPAVPVRTSGRDHILEAVPDAP
                     ALVVSTPGAEPVAEGGYAAALLLDGWAMLGRPDLRAGEEALRRWLAASALVRGQEEGGT
                     VVVVAEPTERAVQALVRWDPAGFARRELAERAELGFPPVSRMASVTGPPEALAAFLRTA
                     GLPPEAEILGPVPAPSAAPGRARRPGDAPPGETWERALIRVVPGRGAALARALKTAVAA
                     RTAKGASAPVRIRIDPPDIG"
     gene            complement(18871..20079)
                     /gene="metK"
                     /locus_tag="CCZ36_RS03995"
     CDS             complement(18871..20079)
                     /EC_number="2.5.1.6"
                     /GO_function="GO:0004478 - methionine adenosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006556 - S-adenosylmethionine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="metK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009187586.1"
                     /locus_tag="CCZ36_RS03995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methionine adenosyltransferase"
                     /protein_id="WP_069737325.1"
                     /transl_table=11
                     /translation="MSRRLFTSESVTEGHPDKIADQISDTILDALLREDPSSRVAVETL
                     ITTGLVHVAGEVTTKAYADIPNLVRNKVLEIGYDSSKKGFDGASCGVSVSIGAQSPDIA
                     QGVDTAYEKRVEGDEDELDKQGAGDQGLMFGYACDETPELMPLPIHIAHRLSRRLSEVR
                     KNGTIPYLRPDGKTQVTIEYDGDKAVRLDTVVVSSQHASDIDLDSLLAPDIREFVVEHV
                     LAQLVEDGIKLDTEGYRLLVNPTGRFEIGGPMGDAGLTGRKIIIDTYGGMARHGGGAFS
                     GKDPSKVDRSAAYAMRWVAKNVVAAGLAARCEVQVAYAIGKAEPVGLFVETFGTAAVDT
                     EKIENAIGEVFDLRPAAIIRDLDLLRPIYAQTAAYGHFGRELPDFTWERTDRVDALRAA
                     AGL"
     misc_feature    20554..20568
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.5"
                     /tool="antismash"
ORIGIN
        1 ccggtgtcgc gaccgcgatc ttcctgctgg cgaccaaggg ccgggtgccc agctatctgg
       61 gctgctcgct ctccttcgtc ggcgtcgcgg ccacgatccg ggcgagcggc ggtgacagcg
      121 cgaccgtcac gggtgcggtg ctggtggtcg gcgcggccct gttcctggtg ggtctcgccg
      181 tgcagcggtt cggcgcgcgg atcatccacg ccgcgatgcc gccggtggtg acgggcgcgg
      241 tcgtgatgct gatcggcttc aacctggcgc cggtgaccgc gtccacgtac tggccgcagg
      301 accagtggac ggcgctggcg gtgatgctgt tcaccggcct cgccgtggtg tgcctgcgcg
      361 gcttcctctc ccggatcgcg atcttcctgg ggctggtctt cgggtacgtg ctgtcctggg
      421 tgctggacct ggtgttcggg aagatccact ctccggcggg cggggcggag gccgtcgacc
      481 actggcgcct ggacctctcg gccgtcgggc aggccgactg gatcgggctg ccgtccttcc
      541 acgcgcccgc cttcgagtgg tcggcgatcc tggtggcact gcccgtggtg atcgcgctcg
      601 tcgcggagaa cgccgggcac gtcaaggccg tcggcgagat gaccggcgac ccgctggacg
      661 acaagctcgg caccgccatc gcggcggacg gcgcggcctc catgctctcc accgccgtgg
      721 gcggaccgcc caacaccacg tactccgaga acatcggcgt gatggccgcc acccgtgtct
      781 actccacggc cgcctactgg gccgccgcct gcttcgcgct gctcttcggc ctctgcccca
      841 agttcggcgc ggtcgtcgcc gcgatcccgg gcggggtgct cggcgggatc accgtgatcc
      901 tgtacgggat gatcggcctg ctcggcgccc agatctggct caacggccgg gtggacctgc
      961 gcaatccgct caacctcgtc ccggccgccg cgggcatcat catcggcgtc ggcggggtca
     1021 cactgaagat caccgacaac ttcgagctgg gcggcatcgc gctcggcacg ctcgtcgtga
     1081 tcaccggcta ccacgtcctg cgggccttcg ccccggccca cctcaagacg caggaaccgc
     1141 tgctggacgc ggggacgtcg gcgtacgacg agaagccggg ccccgagaag agctgagccg
     1201 tgcggggcag cctgggatca ggccgtgcgg gggcggcacg gggccaggcc gtacgggggc
     1261 cggccggggc tcacccggtg gccagggcgt aggcgtactc cggggtgaag gagcccgccg
     1321 cgcccgagca gccgtcggac tcccccggca gcttcaccca caggtacgcg tcgatccggg
     1381 cctcgccggt gcgcgtcgtg ggggtctgcc ccagggcccg gcccgccggg tcgcaccact
     1441 gaccggcggg cggcgcgccg ttgccgttgc ggctggtgtc gacgaccgcg ccgagaccgg
     1501 gcgggccgcc gagcgcggcg aggacccggc gggcgtaggc ggtctcgtcg gcggtgcggt
     1561 ggaagttggc cacgttggtg aagatgccgt cgccgtcggt ggccgccccg gcggcccgga
     1621 gcgcggcggc ctgtttcgcg ggggcgtgcc agcccgagtg gccgccgtcg aagtagaccc
     1681 gggcccgcgg accggctgcg cgcagggtgc gtccggcgcg ggccagcgag gcgaagcggg
     1741 cggcccgctc ggaggcgctc aggcagtcgg agagggcgat ggcgtccggc tccaggatca
     1801 cgatcgccgc acccgcgccg agcccccgag cgaactcccc tatccacgcg tcgtacgccg
     1861 cgaggtccgg ggcgccgccc ttcgacgcgc cgccgcagtc ccggtcgggt atcgcgtacg
     1921 ggacgagcac cgggacccgg cccgcggcgg ccgcgccccg ggtgaccgca cggacctgcc
     1981 cggctatctc gcccgggttg tgggcggcga accagacggc ggcgggccgc gccgcgatcc
     2041 gggactcgat gaccgggcgg cgcgggtcgt cggggtgggc ccgcacccag tccaggacct
     2101 gggagtgcgg gtgccggaag agacggttac ggggcgcggg tgcgggcgtt gccgacgggg
     2161 aggacggggg ctcgggggcg gcgctcggac gggacgtggt gcgggagggg gccggggcgg
     2221 gaacggggcg tgcggagggg gtggacgggg cgggggccgt gggcgtcggc gtgggcacgc
     2281 cggggagggg cccaaggacc ggcggagccg tcggtccggg gcgggcggtg tcgcgcccgt
     2341 cccgatggcc cgcgtcgatc agcccggccg tcgcaccgat cgccaccact gccgaggcga
     2401 cggcgagcag ggcgtgccgg cgggccgcgc ggcggcgttc acggtgagcg gtgcgacgtc
     2461 gtacgcgggt gcccggcact cctcgatccc cttctccggc accgctgttc gtccgttccg
     2521 atgaatactc gggccgatcg gcgccgtggc gagcctaagg ctgggacgct ccgcgcatga
     2581 cgcagatcga gcagttcgca ggaacggccg gggccggccg cccgccggcg ggcgcctccc
     2641 cggtgatcga acgtatgcgg gaatggtgtt cccggtggcc gcccggcgag ggggtggcgg
     2701 tcttcaacac ggcctatctg gaggtcgtcg ggcgggtgga cccggacctc ggcggggacg
     2761 ggcccgacga ccgggaagcc gccgccctgc tggccgtacg ctgcgccgag gcctatctgt
     2821 cggccgtcga gacggccgcg gcgggcgggc ggccgccgga gtgctggcgc ccgttgctgc
     2881 cctgccgccg ccatcccggc gtacgtccgg tgcagttcgc gctcagcgct ctccaggcgc
     2941 acgtgggcca cgacctggtg ctggcggtgg tggacacctg tcgtacgctc gactgcgatc
     3001 cgccggacct ggaaggggag ttcgagcgcg tgggcgatct cctcgccttg ctggaggagc
     3061 ggatccacga cgaactgatg ccgggccccg acgcgttggg gatcgcggat ccgctgaccc
     3121 atctggtgag ctcctggagc ctggagcggg cccgcgaggc ggcctggtcg gcggcccggg
     3181 tgctctggcg gctgcgcgga ttcccttcgc tggccgagga gttccggcag cggaccgacg
     3241 cgggcgcggg gctggtgggg cggcttctgc tcaccccctg ccgctgacgc ccgcgtcggc
     3301 acgccccctg gcctcagtcc tccggaagct cgaccgggcg atctcgtcga agacgtcgcc
     3361 ggggccgggg ttggtcgcgt ccgtcgcccc gccgaactgg tgcatgacgc cccacacggc
     3421 gttcagcgcg gtctgcacgg cgccctcggc ccagccggcc gtccaggaga tgtcgtcccc
     3481 ggcgaggaag atgccccgct tgtcctcggg cagccggtcc tgcatgaagt gggtgaacag
     3541 ccgccgctga tagcggtagt ggccgggcag gttggccttg aacgcgccca tgaaccaggg
     3601 ctcgttctcc caggagacag tgaccgggtt gccgatgatg tggctgcgga tgtcgacgtt
     3661 cgggtagatc tcgccgagcg acttgagcat gacctccatg cgctccttcg gggagagcgg
     3721 cagccacttg aggctgtcgt cgcaccacgt gtaggagagg cagatgacgg cgggcttgtc
     3781 cggcccgtcg tccaggaggt aggtcccccg ggtcatccgg tcggtgagcg tcatcgacat
     3841 ggtgtcgcgg ccggtggtct cgtccttgtc cagccagaac ggccggtcga ccggcacgaa
     3901 cagcttggac gactccatgt agtgggtgcg ctccatcgcc gtccagtggt cgatcgggaa
     3961 gagcgcgtca tcgcagtcga tcttggagag gagcagccag gactgaccgg tgaagaccgc
     4021 ggcccggaag gtacggatgt cgccggtggc gtcggtgacc gtgatgcggt tgcccgccgt
     4081 ccgggtcagc cgggtgaccg caccgcgcgg ctcgccgtcg tgcagggagg agagcgaggt
     4141 gccgagcggc cagtggacga tcttctgcgg ctcgcggtcc cacaggagca gcgggagctg
     4201 ctggctgccg ccgacgatgc cgcggtggtg gtcgtcggcc tcggtgtaga cgacgcggag
     4261 gatctccagg atggagttgg ggaagtcggt gtcccagccg ccggtgccga agccgacctg
     4321 gccgaagatc tcgcggtgcc ggaacgacct gaaggcctcg gactcgcaga ggaagccgta
     4381 gaaggtctgg ttgtcgagcc gctcgacgag ctgcgaccag atctcccgga tgcgcgggac
     4441 gtcgcgctcg cgcagcgccc ggttcatgtc ggagaagtcg gcgccctcct ccaggcaggc
     4501 gctccaggcc tcggccacgt cgcggtagac ctgcggcagg tcgtcgatgg tctcggcgta
     4561 gtgcgactcg cccttgaggt ccacgacggt cgagggtgtg gccggggaga gcgggttggg
     4621 gaagggccgg gtctgaaggc ccaccaggtc gatgtagtgc tggagcgccg tggaggaggg
     4681 cgggaagcgc atggcgccca tctcggcggt gaggtcgccg tcgcaaccgt cgaagccgac
     4741 ggtgcgcagc cggccgccga tctggtcggc ctcgtacacg acgggcttga ggcccatctt
     4801 catcagctcg tacgcggcga tgatgccgga gagcccgccg ccgatgacgg cgacctcctg
     4861 gccgtgctcg gtcgccggta tctgcccgag gccggccggg tgggcgagga agtcgtcgta
     4921 cgcgtacggg aagtccggcc cgaacatggt gatcggcggg gcggccgcgt cggtgtgctg
     4981 gacggcgttg ggcaccgtgg acgtcatggg gtgcggactc cttgcggggt acggaaagtt
     5041 cggggagggt gcgggctcag gcgagggagc cgtagaggcc ggggcggcgg tccgcgagat
     5101 acgggttggc ggcccgcgag gcggccagga actccgggtc cacctcgccg atcaccagct
     5161 cctcgccgcg tccggcgcgg gtgcggaccg ccccgtcggg gccggccagg cagctgagcc
     5221 cgacgaactc gaactcccct tccgggccgg tgcggttgac gtacgccacg tacatctggc
     5281 tttcgaaggc ccgtacgggg acgacggatt cggcgacgaa ctggaagggg tgcatctgcg
     5341 cggtgggcac cagcagcaga tcggtgccgg ccagggcgtg cgcccggacg ttctccggga
     5401 actcgacgtc gtagcagatc agcaggccga tgcggatacc gtcgatgtcg gcctggacga
     5461 cggtctgctc gccgggggtg aaccactcct gctcgaagca gccgaacagg tgggtcttgc
     5521 ggtagttcgc gaggcggacc ccgtcggggg cgatgagctg ggaggcgttg aagatcagct
     5581 ccccgtcgcg ctccgggtag ccgtagagga cggcgaggcc gtggcgtacg gcgatctccg
     5641 cgatcgcctc ggcaccgggt ccgtcggcgg gctcggccag gacgggcacg gcgtcgccga
     5701 tggcgtatcc ggtgaggaac agctcggggg cgaccagcag ccgggctccg gcaccggcgg
     5761 cccgggcggc ggcctcgtcc agcgtcttca ggttctcggc gacggcgccg ggccgtccgg
     5821 agctctggag cagggcggtg cgcaacgacg gcatggctga cctcgggcgg tgcgggcggg
     5881 gtggggagac gtatcgaagg tacgtggccc ggatcggccc ggacaaggcg cgagtgttgc
     5941 gcgtcgaccg ttgattcgtt gcgcggaatg ggccccgggc ggcgaatcgt tgcgtcgggc
     6001 atcaccgcag gtcagcgggg tgatgtgcgc cacccgtctc aggccggcgg ggcctccgcg
     6061 gagtaccgcc gcagcagcgg cgagagcacc agcaccgact tcgtacgctc cacgtacggc
     6121 tcccccgcga tgcgctccag gacctgttcg aagtggcgca tgtcagcggc gaagacctgc
     6181 accaccgcgt ccgcgtcgcc ggtcaccgtg gaggccgagg cgatctccgg gtagcgggcg
     6241 aggccctgct tgatcgcctc cggggaggtg ttgcggctgc agtagatctc gatgaacccc
     6301 tcggtctccc agccgagcgc cgccgggtcg acccgcacgg tgaaaccggt gatcgcgccc
     6361 tcggcgcgca gccggtcgac acggcgcttc acggcggggg cggagaggcc gacgatggcg
     6421 ccgatgtcgg cgtaggagcg ccgggcgtct tcggcgaggg cgaggacgat gcgttcgtcg
     6481 aggtcgttca ggcgcacgtc gggcggttca ctatctctgc ggtgggtcgg cttgcgggag
     6541 gcggtgcgtg ccgcctcccg cagtagacca cgggccgccg ctccgggcgc gcccggagcg
     6601 gcggaaccgg ccgtcagaag gggaactgcg agcggccgtg ctggatggag atccacttct
     6661 gggtggtgaa ggcctcgatc atcgagtcgc cgttcagccg gcccagaccg gagctcttct
     6721 caccgccgaa ggggacgatc ggctcgtcgt ggacggtgcc gtcgttgatg tggatcatgc
     6781 cggtgtggat gcgctgcccg acccgcaccc cgcgctcgat gttgccggtg tggacggcgc
     6841 cgctgagccc gtacggggtg tcgttggcga tgcggacggc ctcgtcctcg ccgtcgaagg
     6901 ggaccagcag ggccacgggc ccgaagatct cctgctgcag gacgggcgag tcggcggcga
     6961 gaccggtcag cacggagggg ctgacgaggt tgccgtcggc gcggccgtgc aggagggccg
     7021 tcgccccggc cgccacggtc tggtcgacga gcttggagac ggactcggcc tgcgaggagt
     7081 tgatcagcgg accgatctgg gtggccgggt cggcggggtc gccgacggtg agagacgcga
     7141 ccttggcgac gaacttctcg gtgaactcgg cctccaccgc gcggtcgacc aggatgcggt
     7201 tggcggccat gcagacctgg ccctggtgga cgtaccggct gaagaccgcc gcgtcgacgg
     7261 cgtagtccac atcggcgtcg tcgagcacga tcagggcgct gttgccgccg agttcgagga
     7321 cggcgcgctt gaggttctgg gcgcagacgg tggcgacgtg gcggccgacc ttgtccgagc
     7381 cggtgaagga gatgacctgc ggcacggggt gctccagcag ggtgtcgccg atctccgcaa
     7441 tgtcggtgat cacgacgttc agcagtccgg cgggcagacc ggcgtcctcg aagaccttgg
     7501 cgagcagggt gccgccgcag atcggggtgt tctggtgcgg cttgaggacg acggcgttgc
     7561 cgagggccag cgcgggagcg acggacttca gggagagcag gaaggggaag ttgaacgggc
     7621 tgatcacgcc gacgacgccg acgggcacgc ggtagacgcg gttctccttg ccctcggtcg
     7681 gcgaggggag gatctgtccg gccgggcgca gcgccagctg gatcgcctcg cggaggaact
     7741 ccttggccag gtgcagttcg aaggcggcct tcagccgggt gccgccgagc tcggcgacga
     7801 tcgcctcgcc gatctcctgc tcgcgctcct cgacgatgcc gagcgccttc tccaggacgg
     7861 cccgcctgct gtacgggttg gtgtccgccc acgcctgctg ggcgcgctcg gcggcccggt
     7921 aggcctggtc gacctcgtcg gcggtggcga ccgggatcga ggcgagcttc tccccgtcga
     7981 acgggttgaa gtcgatgatg tcccaggacc ccttccccgg cctccactcg ccgtcgatgt
     8041 actggtgggc caggtcagtg aagaaggaca tgagatccct taccgcagag aggcaggcag
     8101 ctgagtgcgg ttcatattac tgagatttca acagagttga agcggacccc cggccacggg
     8161 agcaggcccg gaaacgaccc cgccccctcc ggcgtggaac agccggaggg ggcgaggtcg
     8221 ttgaggtgct cggggaatca actccagctg gcgtgcagcg gcttgccctc ggcgtaaccg
     8281 gcggcactct ggacgccgac gaccgccttc tcggcgaact ccgcgaggga gccggcaccg
     8341 gcgtaggtgc aggaggaacg aacgcccgcg atgatcgagt cgatgaggtc ctccacgccc
     8401 gggcgggccg ggtcgaggaa catccgcgag gtcgagatgc cctcctcgaa gagcgccttg
     8461 cgggcgcggt cgtaggcgga ctcgtccgag gtgcggttct tcacggcgcg ggcggaggcc
     8521 atcccgaagg actccttgta gaagcggccg tcggcggact gctggaggtc gccgggcgac
     8581 tcgtacgtgc ccgcgaacca ggagccgatc atcacgttgg acgcgccggc ggcgagcgcc
     8641 atggcgacgt cgcgcgggtg ccggacgccg ccgtccgccc agacgtgctt gccgtgcttc
     8701 ttcgcctcgg cggcgcactc caggacggcg gagaactgcg ggcggccgac gccggtcatc
     8761 atccgggtgg tgcacatggc gccggggccg acgccgacct tgatgatgtc cgcgcccgcc
     8821 tcgatcaggt cgcgcacacc ctcggcggcg acgatgttgc ccgcgacgat cgggacctgc
     8881 gggtcgagcg cccggacggc cttcaccgcg ctgatcatgg attcctggtg gccgtgggcg
     8941 gtgtccacga cgaggacgtc ggcgcccgcg tccaggagct gcttggcctt gccggccacg
     9001 tcgccgttga tgccgacggc ggccgcgatg cgcagcttgc cctcggcgtc ggtggcgggg
     9061 gtgtagagcg tggcgcgcag ggcggccttg cgggtgagga tgccgacgag gcggccgtcg
     9121 gcgtcgaccg cgggggcgag cttgcggttg gcgccgtcga gcttgtggaa ggcgtcgcgc
     9181 gggtcgatgt ccgcgtccag cagcacgagg tccttggaca tgacctcgga gagctgggtg
     9241 aagcggtcga cgccgctgag gtcgtgctcg gtgacgacgc cgacgggacg gcggtcggcg
     9301 tcgacgacga cgcccgcgcc gtgcgcccgc ttgggcagca gcgagagcgc gtcggcgacg
     9361 gtctggccgg gggccagctc gatcggggtg tcgaggacga ggtggcgcgt cttgacccag
     9421 gagatgacgt cggtgacgac ctcgatcggg atgtcctggg ggatgacgac gaggccgccg
     9481 cggcgagcga cggtttcggc catccggcgg cccgcgatgg cggtcatgtt ggcgaccacg
     9541 agcgggatgg tggtgccggt tccgtcgggc gacgagaggt ccacgccctg acgggagccg
     9601 accgcggagc ggcccgggac catgaagacg tcgtcgtacg tgaggtcgta cgggaccgcg
     9661 ggggactctg tgtagcgacc ggtgcccggc tcaagaaaac gcataagact cattttttca
     9721 tacgaaaccg cgcaggtcgt ttcccgaaga cacagcaaaa gacccccgct ttcgtctgat
     9781 cctccgaaga ggcggccggg ggtcccgggc aagcgaacct gccttaccca cggactctac
     9841 ccgaacagga ttcgaagcat tcgtgatcac catccctgga ccaggtgaca aggggtcagg
     9901 tagcttcaaa gccgcaggtc tcgggggtgt cggaagcgtc gacccggctc gtcggcaccc
     9961 ctgggcacac cgtttgaccg gagaggatcc cgatccgcct gtggacagcg aactgccgga
    10021 catctactgc ccgttcccgc agcggaccaa tccgcacgtg gcgcacaccc gggaccatct
    10081 ggacgactgg accagacgga cgggtctggt ccatcgcgag tccgcgaggc accgattcga
    10141 acaagccgac ttcggggcgt tcgtcggcat ggtctacccg acggccgacg aggaacatct
    10201 cgatctggtg gccgactggt tcgtctggct cttcctggtc gacgaccagc tcgacgacgg
    10261 ccatctcggc cgttcacccg ccctggtgag aagtgtggtc gaacggatgc gcgcggtcgt
    10321 cgacggctcc gccccgagcc gctgccgggc gaggaggtcc cggccgccgt gaccgccctg
    10381 gctgacttgt ggaaacgtac gacgccgaac gcggccccgc actggcggac ccggttcgcc
    10441 tggcatctgg tgacgtacct cacgaccgcc acgacctggg aggtgggcaa ccgcgccgag
    10501 gacgtggtgc cctcggagga gacgtacatc gccaagcggc ggcacaccgg ggccatccac
    10561 gtctgtatgg acctcataga gatcgtggcg ggcatcgagg ccccggagtc gctgcacaac
    10621 gacccccgct tcatcaccgc cctggaagcc gcgtgcaacc acgtctgctg ggcgaacgac
    10681 gtgtactcct tcgagaagga gcaggtgctc ggggagatcc acaacctcgt ccacctggtc
    10741 cgccaccacc ggggcctcgg ggagcagcag gcgctggacc acgtcgcgga gcggctcgcg
    10801 atggagaccg agcggttcct gaccgccgag gacgagctgc tggagctgta tccggagctg
    10861 tccggtctgc tcgtgcccta cctggacgga atgcggagct ggatgcgcgg caacctggac
    10921 tggtcgcgcc agacgccccg ctacaacccc gccgacgtgg ggcagtacga ggagcccgag
    10981 gagtatctgg aggagacggt gctgggcgtc ccgcccgcgc gcaccgaggc cgcggccccc
    11041 gccccgtgcg cggccaaggc acccccggcc ggttgagggc ggggcgcata ccgagggccg
    11101 tgcaccttgc ggggtgcacg gccctcgcgg gtcttcggcg tcactccccg tcggggtcgg
    11161 cccgctccag cgccgggcgg acgcccgccg cggactcggt gagcagatag tcggccgcgg
    11221 cggtgtccgt gaccaggctg gtgaccaggc cggagcgcag caccgcgccg atcgccgccg
    11281 ccttgcgctg gccgcccgcg atcgcgacca cctcggggat ccggcgcagc cggtccgcct
    11341 ccacggtgat gcagcgctcg cccaggtcgc ggccgacccg acggccttcc gcgtcgaaga
    11401 ggtgcgcgga catctcggcg gcgacgccga gcgaggcgta gtgggcgcgc tcctcgtccg
    11461 agagcatgtc gtggaccgtg gagatgccgg gctcccagga gccgatggag acggcggcga
    11521 cggtgacctt gtcgaagtac tcgaaggcac gggcgatacc ggtctggtcg cgcagcgcgg
    11581 cggccgtcgc ggggtcgggc agcagcatcg gtgcgtagat ggggtgcgcc tcgccaccgg
    11641 agacctgggc ggccctgcgg accgcctcga ccgagccgcg ctcggcggtg cccgcgtcgt
    11701 acaccccggt cagctggacg accgtgcagg gcggcagccg gtcgagggcg gccgccatgt
    11761 ggatggtgga gcggccccag gccaggccga gcacatcgcc ctcggccacc agctcgccca
    11821 ggaggtcggc cgcgacctcg cccagattct ccgggtcggg ggcgtcctcc tgttcctcgg
    11881 ccggggattc gacgaccacc gcgtgccgca gcccgtagcg ggcgcgcagg gcgtcggagc
    11941 gttcggcgtc cagctcggcc gggacccgga tctcgatgcg cacgagatcg cgttcgaggg
    12001 cggtctccag gacccgggcc accttgaagc ggctcacgcc gaactcctcg gcgatctgga
    12061 tcttggactt gccctccagg tagaaccggc gggccatggc cgccgcctgc accagctccg
    12121 cgggtcccat ccgcatggct gaccgacccg ccgagatgcc agacaccgcg atctcctcac
    12181 tgctgttcac acgcccgata cgccgttcat cctgtcagat ccggcgatcc ttgatcggcc
    12241 ctgtcggacc gcgttcatct gcccttggtt cagtggtcgc atgcccaggg ggccgcggcc
    12301 gtcgccacgt ccgccagggc ccgcaggtcc cgcaccgccg ccgccgggtc cgccgccccg
    12361 tagaccgcgg atccggcgac gaagacatcg gctccggcct cggcgcagcg ttcgatggtg
    12421 gtggccgaga caccgccgtc gacctggagc cacagttcga gaccgtgctt gctgatcagc
    12481 tcccgggtac gccggatctt cggcagcatg atgtccagga atgcctgccc cccgaagccc
    12541 ggctccaccg tcatgatcag cagcatgtcc agctcgggga gcaggtcctc gtacggctcg
    12601 atgggcgtcg cgggcttgag cgccatcgag gcgcgcgccc ccttcgcccg gatctcccgc
    12661 gccaggcgca ccggcgccgc ggcggcctcg gcgtggaagg tgacggaccc ggcgccggcc
    12721 tccacgtaac tcggggccca gcggtccgcg tcctcgatca tgaggtggca gtccagcgga
    12781 gtgtccgtcg ccttgctgag cgcctcgacg atcggcacgc cgagggtcag attgggcacg
    12841 aagtggttgt ccatgacatc gacgtggagc cagtccgcgc cttcgacggc cttcgcctcc
    12901 tcggcgagac gcgcgaaatc ggcggacagg atgctggggt tgatctgcgc catgacccaa
    12961 gcctgccacg tctccggccg gttccccgcc tcgatcccct ccgaagcctc acacggccct
    13021 cacagtccgc acattctggg cattttgcca gcgctttact gttcttttgc tgtatgggcg
    13081 ggtgcgctga cgcggtgata ttcagccggt ccggcgcagc agagccagat acatcgcgtc
    13141 cgtgccgtgc acatgcggcc agagctggac gtcgggcccc tcgcccaggg cggagacccc
    13201 gggcatcagc gggcgggcgt cgacccactc cgcctcgacc ggttccccgc cgcgcccctt
    13261 gagcacgtcc tcgacgacca cccgggtctc cgcgagatgc ggcgagcagg tggcgtaggc
    13321 gaccgcgccg ccgacccgca cggccttcaa cgcctcgcgc agcaggccgc gttggagcgg
    13381 ggcgaaggcc tccaggtcct cggggcgccg ccgccagcgg gactccgggc ggcggcgcag
    13441 cgcgccgagt ccggagcagg gcacgtccat caggatgcgg tcgaaggtgc cgggcagcca
    13501 cggcgggcgg gtgccgtcgg tggtgatcac ctggtacggg ccggggttac cggcgagcgc
    13561 gcgctcgacc agccgggcgc ggtgcggctg cttctcggcg gcgagcagcg tcgcgccgcg
    13621 ctcggcggcg agcgccgcga ggagggcggc cttgccgccg gggcccgcgc agccgtccag
    13681 ccagcgggtg tcgcggccct cgacggggac ggctgccagg gcggcggcga cgagctggct
    13741 gccctcgtcc tggacgcccg cccggctctc ccggacggcc tccagcgcgc cgggctcgcc
    13801 gccctcggcc atccgcacgg cgtacgggga ccagcggccg ggcagggagt tgtcctcgcc
    13861 gagggccttg accagctcct cggtggtgga acggccgggg cgggcggcca gggtcacctc
    13921 gggtcgctcg ttgtccgcct ccaggaggtc ctcgatgccg gcccggccac cgcccagcgc
    13981 gtcccagagg gcggagacga tccagcgggg gtgggagtgg acgacggcga ggtgctcctc
    14041 ggcgtcctcg tcgtacggcg gggcgacctt ctcgacccag ccgtcgaggt cgtgcgcggt
    14101 gaccttgcgc agcaccgcgt tgacgaactt ggctcgcccc tcccccagca ccacccgggc
    14161 cagctccaca ctggcggaga cggccgcgtg ggtggggata cgggtgccga gcagctggtg
    14221 gacgcccatg ttgaggacgt ccaggaccgg cgggtcgacc tcgcgcaggg gccggtcgat
    14281 gcaggccgcg acgatcgcgt cgtacgtccc ctggcggcgc agcgtcccgt agaccagctc
    14341 ggtcgccagc gccgcgtccc ggccgtcgaa gtcgcccttg gcgcgggcct tcttcagcag
    14401 cgggggcagc acgaggttgg cgtacgcgtc gcgttcgtcg acggcccgca gcgcctcgaa
    14461 ggcgaggaag cggaccgggt ccttcttggg ccggcggtgg ggcttggcgg gacggcgacg
    14521 cggctggtcg ttcacgtgaa aggtgctccg ctggaggtga gaggggcgaa ccctcccagc
    14581 ctacgacgcc gtccgcggcc tcccgaacgg cagcccgggg ctcgcggacg ccgccccggg
    14641 ccccgtaagc ccgctacaga cccagcagct cgccgtgggc gatccggacg ccgcgcgccc
    14701 agtcggcggc ccgcatcggc ttcttgccct gcggctggac ccagagcagc tcgacggcgt
    14761 gcgatccggt cccgacgtac acgttgttct tggcggccga cagctcgccg ggagccaggt
    14821 ccgtgcggtc caggacgggg gtcgcctgga tcagcttgag ccgctcgccg cggaacaggg
    14881 tccaggcgcc cggggccggg gtgcagccgc ggatcacccg gtcgacccgc agggcgggtg
    14941 cggaccactg gacctgggcg tcctcgacgg tgattttcgg agccagcgtg acaccctcgt
    15001 gcggctgggg cacggcgtgc agcgtgttgt cctcgatacc gtccatggtg gcggcgagca
    15061 gcccggcgcc ggcgaacgcg agccgggtga gcaggtcgcc gctggtgtcg gtgggacgga
    15121 cctcctccgt gaggacgccg tagaccgggc cggagtcgag cccctcctcg atcaggaagg
    15181 tcgacgcgcc ggtcacctcg tcaccggcca tcagggagtg ctgcacgggg gcggcgcccc
    15241 gccaggcggg cagcagcgag aagtgcaggt tgacccagcc ccgggcgggc acatcgaggg
    15301 cggccttggg caacagggcg ccgtaggcga cgaccgggca gcagtccggg gcgatctcgc
    15361 gcagtcgggc gaggaactcc tcgtcccggg gcctggcagg cttgagcacc tcgatcccgg
    15421 cctcctccgc ccgctcggcc accgggctcg cgacgagtcg gcggccccgc ccggcggggg
    15481 cgtcgggacg ggtcacgacg gcggccacct catggcggtc ggaggcgatc agggcgtcca
    15541 gggcggggac ggcgacttcg ggggtgccgg cgaagacgag cttcatgggt ggctgactgc
    15601 ctctcgggcc aagacgtacg gtgacgagca gcacaccagt ctagggtctc gggcggggcc
    15661 gggcccggcc gctcccttgt gtaggggcgg cgactccctt gggggggggc tggccgctcc
    15721 cttgcgcgga cctcgccgcc tcccttgcgc gggggcggcg accggggggc gtacgcgcgc
    15781 cgcgcacgcc ccgtgcatat gcacatacgc cccgatagcg tgaccacata cccggctcgg
    15841 gcgttggtca aaggagattg accgaagcgg gccgccccga ttgcggcccg atccctttca
    15901 acgccggttc gagaggcttc ttcatggccg accacgcaac gcacgacgcc caagcgcggg
    15961 ccagtctgca tcttctggtg cgggacatcg agcgggtcag gcggcaggtg gacgcgctgc
    16021 gcaccctcac cgcccagctg ggcaatgtct accgtccgcg ccgctccggc ccttccgcgg
    16081 gcttcgtcgt ctacggcagg gccccggccc ccaccgtccg cctcgcgcag gagctgcggg
    16141 acagcgtcga gaccctggtg acggccgcgg tggacttcga ccgctcgctg ggcttctcct
    16201 gggacgcggt gggctccgcc ctcggcgtca ccaagcaggc cgtccaccgc cgttacggaa
    16261 cccgccgcgc caccccgcag cccgccgccg agacgggcgg cgagaacacg gctgtgccgc
    16321 gcccggtctc cgtcggcacc ggcctcaccg gatcctccgc caagtccggt tccccggtgc
    16381 cctcggtccc ggcggcccgt tcgatgccgc cgcagccgtc ggcggccccc cagccggccc
    16441 gtgaggagct gcgccccggc gcgttcccgg gcccgcgcaa cggctgaccg cacgccggcc
    16501 ttctgcccca ccgtgccggt cgcacggcgg ggcagtcccc tgtccgggcc ccgggcatac
    16561 ggcccgcggg caccggctca gccgatgtcc ggcgggtcga tcctgatgcg taccggcgcg
    16621 ctcgccccct tggccgtacg ggccgccacc gccgtcttca gggcccgggc gagcgccgcc
    16681 ccgcgccctg ggaccacccg gatcagggct cgctcccagg tctcgcccgg cggtgcgtcc
    16741 cccggcctgc gggcccgccc gggcgcggcc gaaggggccg gcaccggtcc caggatctcg
    16801 gcctccggcg gcagcccggc ggtccgcagg aacgcggcca gggcctcggg cgggccggtc
    16861 accgaggcca tccgggagac cggcgggaag cccagctcgg cgcgttccgc cagctcccgc
    16921 cgggcgaacc ccgccggatc ccagcggacc agcgcctgca ccgcacgctc cgtcggctcg
    16981 gccacgacca ccaccgtgcc gccctcctcc tgcccccgca ccagcgccga cgccgccagc
    17041 caccggcgca gcgcctcctc ccccgcgcgc agatcgggcc ggccgagcat cgcccagccg
    17101 tccaggagca gggccgccgc gtaccccccc tcggcgacgg gctccgcgcc gggcgtggag
    17161 acgaccaggg ccggggcgtc gggcaccgcc tccaggatgt ggtcgcgccc cgaggtgcgg
    17221 acgggcacgg cgggaaaggc ccggcccagc tcctccgcgg tgcggcgggc gccgacgatc
    17281 cgggcgcgca gccgggtgga gccgcactcc gggcactgcc aggcccgctc ggcctgcccg
    17341 caccaggcac agttcagatc ctgctggtcc ggcgcttcca ggggccccgc gcagtgccgg
    17401 cagcgggcgg gggtgcggca gcgttcgcag gcgaggcggg gggcgtaacc gcgcctcgga
    17461 acctggatca gcaccggccc ggtgcgcagt ccgtcgcgca cggcccccca ggcgaggctg
    17521 ggcagccggg cggagcgggc ggccccgtcc cgggccagct cgccgtcccc gaccgtacgg
    17581 acgagggggg cggcccggcg cagccgctcg cggtccgcga ggagcggcag cgcccagccg
    17641 ctctccacga gctgggccgc ttctaccgtg cagctggttc cgccgagcag gaagccgcag
    17701 cggccctggg ccgcccgcag ctccaggacc tcgcggacat gggggaaggg ggcgttgtcg
    17761 tcgctgtggc tggagtcgcc gtcgtcccag acgacgacga ggccgaggtc gcggacgggg
    17821 gcgaacatgg cggcccgggt gcccacgacc gcccgcaccg agccccggcg taccgcgagc
    17881 cactggcggt agcgcttctc cgggccggat tcggcggtca gcagggcgtg cctccccgcg
    17941 ccgagcgcct cggtcagggc cgcgtcgacc cgggcggcgg accgcccgtc cgggacgacg
    18001 acgagggcgc cgcgccctga ggagagcgtc gccgcgacgg ctccggcgat ctccgcgggc
    18061 cagtgcggtc cgggcagcgc ggtccacacc gcacgcgggg cgccgccctc ggccagggct
    18121 cgcaggaagg ccgggccctg ggcgtaccgc tcccaggtgc ccgggtccgg gggcggaggc
    18181 gggggcagcg ggtccgggga gggcttggcc tcggcgcggc cgttgcgggg cgggacggca
    18241 agctggagga catcggcgag gctgcccgcg taccggtcgg cgacggcgcg gcagagggcc
    18301 agcagctcgg gcccgagaac cggctccggt gagaccacgg aggcgagggc ggccagcgcg
    18361 ccccggtagt cggagtcggc gcggcgctcg acgatgaagc cgtcgatcag gcccccgccc
    18421 tcccgtcgcc cgccctggac gttgcgcccg ccggccccga accggacccg cacccggacg
    18481 cccggctgtg cgtcggcgtc cagctcctgg ggcaccgcgt agtcgaagta ctggtcgagg
    18541 tggaggacgc ccttgttgac caggacgcgg gcgacgggca gctcttcggc cagggccgcg
    18601 ccgcgccagg tccgcggctt ggcgcgcggc accttggccc ggcgcacggt ctccctgatc
    18661 agcgcaagct gctccggcgc cccggcaccc ggttcggcgg actgctcgtt ctcgctgctc
    18721 acagctgcat tcctaccaga gggcgctgac agtccggaga gcacggaccg gcgtgggagg
    18781 acggaccgcc gcgggagcac ggcagcgggg cccggccacc acgttcggtg tccgggcccc
    18841 gctgttgtgt gctggtggga cctgcggtcg ttacagaccc gcggccgcgc gcagcgcgtc
    18901 cacgcggtcc gtgcgctccc aggtgaagtc cggcagctcc cggccgaagt ggccgtacgc
    18961 ggcggtctgg gcgtagatcg ggcggagcag gtcgaggtcc cggatgatcg cggccgggcg
    19021 gaggtcgaag acctcgccga tcgcgttctc gatcttctcg gtgtcgaccg cggcggtgcc
    19081 gaaggtctcg acgaagagac cgacgggctc ggccttgccg atcgcgtacg cgacctggac
    19141 ctcgcagcgg gcggcgagcc cggcggccac cacgttcttg gcgacccagc gcatcgcgta
    19201 cgccgcggag cggtcgacct tggacgggtc cttgcccgag aaggcgccgc caccgtgacg
    19261 ggccatgccg ccgtaggtgt cgatgatgat cttgcggcca gtgaggccgg cgtcgcccat
    19321 cgggccgccg atctcgaagc ggccggtcgg gttcaccagg aggcggtagc cctcggtgtc
    19381 cagcttgatg ccgtcctcga cgagctgcgc gagcacgtgc tcgacgacga actcgcggat
    19441 gtcgggggcg agcagcgagt ccaggtcgat gtccgaggcg tgctgcgagg agacgacgac
    19501 cgtgtccagc cggaccgcct tgtcaccgtc gtactcgatg gtgacctggg tcttgccgtc
    19561 ggggcgcagg taggggatgg tcccgttctt gcgcacctcg gagagccgcc gggagaggcg
    19621 gtgcgcgatg tggatcggga gcggcatgag ctccggggtc tcgtcgcagg cgtacccgaa
    19681 catcaggccc tggtcgcccg caccctgctt gtcgagctcg tcctcgtcac cctcgacccg
    19741 cttctcgtac gcggtgtcga cgccctgcgc gatgtccggc gactgggcgc cgatcgacac
    19801 cgagacgcca caggaagcac cgtcgaagcc ctttttggag gagtcgtagc cgatctccag
    19861 aaccttgttg cgcacgaggt tggggatgtc ggcgtaggcc ttggtggtga cctcgcccgc
    19921 gacatgcacc agaccggtgg tgatcaaggt ctcgacggcg acgcgcgagg aggggtcctc
    19981 acgcaggagc gcgtcgagaa tcgtgtcgct gatctggtca gcgatcttgt cggggtgacc
    20041 ctcggtgaca gattccgagg tgaaaaggcg gcgggacaca tcgctccctg gggttgcagc
    20101 ggctgctggc tgatcatggg tggtacgtcc gagagctgcg ctcggcgcgt gccgtcggcc
    20161 agtttatcgg tcacttcccg cgaccgggcc aggtgtctcg ccctttggga ggttcgtgac
    20221 gtgcgccaca cagatcacca gtaggacaat tcaccctcct cggtcgccgt tttcggcgtt
    20281 atggggcgtt ttcgctcggc cgaagggctg atcaggaatt cggctggaac ctggcggaaa
    20341 ccagatccca gatcgtgtcg gcaagggctt ccttggggcc gtacggcacc ggcgtctcct
    20401 ggccgtcggc ggcgaggacg accgcctcgt tctcctccga gccgaaggtc ttgcgctccc
    20461 ccacctcgtt gaccacgaga aggtcgcagc cctttcggcg gagcttggca cgcccgttgg
    20521 ccagcacgtc gtcggtctcg gcggcgaatc cgacgacgat ctggtccggc ctggcccgct
    20581 cccccgcgac ttcggcgagg atgtcggggt tacggaccag ggtgagcgcg ggcgcctcct
    20641 cgccgtcctg cttcttgatc ttgccggtgg cgtactcgga ggggcggaag tcggccaccg
    20701 cggccgccat caccaccacg tccgcgtcgg cggcggcctt caccacggcc tcgcggagct
    20761 ggacggccgt gccgacccgc aggacgtcgg ctccggccgg gtcgggcagc ccggtgttgg
    20821 cctcgatcag ggtgacctgg gctccccggg ccacggcggt gcgcgccagc gcgtacccct
    20881 gcttgccgga ggagcggttg cccaggaagc gcaccgggtc gagcggctcg cgggtgcctc
    20941 cggcgctgac caccacatgg cggcccgcga ggtccgtctc cggaaccccg cgcgccagca
    21001 cccggcggca gacctcgaag atctcgccgg ggtcgggcag ccggcccttg ccggtgtcga
    21061 cgccggtgag ccgccc
//
