LOCUS       NZ_CP021707            22343 bp    DNA     linear   CON 05-MAR-2024
DEFINITION  Streptomyces sp. S063 chromosome, complete genome.
ACCESSION   NZ_CP021707
VERSION     NZ_CP021707.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. S063
  ORGANISM  Streptomyces sp. S063
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Complete genome sequence of Streptomyces sp. S063, a producer of
            anti-complement compounds and various secondary metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7614683)
  AUTHORS   Chen,L. and Zhao,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAY-2017) School of Life Science and Biotechnology,
            Dalian University of Technology, Linggong Road 2nd, Dalian, Liaoning
            116023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAR-2017
            Assembly Method                   :: Canu v. 1.4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:19:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,905
            CDSs (total)                      :: 6,817
            Genes (coding)                    :: 6,244
            CDSs (with protein)               :: 6,244
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 574
            CDSs (without protein)            :: 573
            Pseudo Genes (ambiguous residues) :: 0 of 574
            Pseudo Genes (frameshifted)       :: 432 of 574
            Pseudo Genes (incomplete)         :: 192 of 574
            Pseudo Genes (internal stop)      :: 13 of 574
            Pseudo Genes (multiple problems)  :: 61 of 574
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:16:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 752261
            Orig. end                         :: 774604
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP021707.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Xinqing Zhao, Life Science
            and Biotechnology, Shanghai Jiaotong University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22343
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="deazapurine"
                     /region_number="6"
                     /rules="(GTP_cyclohydroI and PTPS and QueE and QueC and not
                     (dpdA1 or bTGT))"
                     /tool="antismash"
     cand_cluster    1..22343
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /kind="single"
                     /product="deazapurine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22343
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:12343](-)"
                     /cutoff="20000"
                     /detection_rule="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /neighbourhood="10000"
                     /product="deazapurine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12343)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /neighbourhood="10000"
                     /product="deazapurine"
                     /protocluster_number="1"
     misc_feature    complement(314..333)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.62"
                     /tool="antismash"
     gene            complement(320..793)
                     /locus_tag="CCZ36_RS03325"
     CDS             complement(320..793)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122977.1"
                     /locus_tag="CCZ36_RS03325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_069736092.1"
                     /transl_table=11
                     /translation="MVERQETSEDAVMTRIGQAIMLLHGGDREEARNRFGALWSELGAD
                     GDALHRCTLAHYMADTQDDPGDELAWDLRALTAAEGAGGGRSAQHPDLPAVRAFYPSLH
                     LNLAADYLKLQRPDSARIHLQRARAAAASLPDDGYGDGVRAAIDRLELRLRDQ"
     gene            complement(910..1599)
                     /locus_tag="CCZ36_RS03330"
     CDS             complement(910..1599)
                     /EC_number="3.2.2.27"
                     /GO_function="GO:0004844 - uracil DNA N-glycosylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006284 - base-excision repair [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015607231.1"
                     /locus_tag="CCZ36_RS03330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="uracil-DNA glycosylase"
                     /protein_id="WP_176734681.1"
                     /transl_table=11
                     /translation="MDVTDIDLLPESWRGVLGEELQKPYVKELADFVEEERAKGPVYPP
                     REQVFAALDATPYDKVKVLVLGQDPYHGAGQGHGLCFSVRPGVRTPPSLRNIYKEMQQE
                     LGLPIPDNGYLMPWAEQGVLLLNAVLTVRGGEANSHKNKGWEKITDAVIRAVADRPDPA
                     VFVLWGNYAQKKLPLIDEERHIVVKGAHPSPLSAKKFFGSRPFTQINEAVAAQGHQPID
                     WRIPDLG"
     gene            complement(1698..3278)
                     /locus_tag="CCZ36_RS03335"
     CDS             complement(1698..3278)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105163.1"
                     /locus_tag="CCZ36_RS03335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_128817002.1"
                     /transl_table=11
                     /translation="MFYRASLQAAAALASLSLLAGCGLLSDSGSETDQKITVGTTSSPS
                     TLDPAAAWDGSWELMRNVYQTLVSFPTGSTSPEPDAAESCKFTDATSMAYRCTLKKNLK
                     FSNGEKLDAEAVKYSIDRIVDIHFKGGPAGMLGSLDRIETKGEDTVVFHLNKSDATFPF
                     ILATPAMSLVAPGDYRKDKIRDDGKVTGSGPYLLESYEGGKTAELKKNPDYNGFAKRKN
                     DAVTIRYFEKSADMVSALKADEIDATYRGLTAEEVVSLEDNKDDNAGLQIVESTGADIR
                     FLVFNPKDPAAANPAVRKAIAHVVDRDALVAKVYRGTAEPLYSMIPKGIAGHTTSFFDT
                     FGDPDADKAKSILSGAGITEPVKMTFWYTTDRYGSATEPEFQELKRQLEASGLFKITLR
                     GEPWQKFQEGFNKGEYPVFGRGWFPDFPDPDNFVAPFVGQEPVTGSPYINKEITQQLIP
                     ASRQESDRGAVSKQFERAQEILVDDVRLLPLWQGKLYIAAGEDIGGGERALDPQTVMQL
                     WELYRKASW"
     gene            complement(3397..4152)
                     /locus_tag="CCZ36_RS03340"
     CDS             complement(3397..4152)
                     /NRPS_PKS="Domain: PKS_KR (8-172). E-value: 1.4e-08. Score:
                     26.8. Matches aSDomain:
                     nrpspksdomains_CCZ36_RS03340_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010062246.1"
                     /locus_tag="CCZ36_RS03340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_065489216.1"
                     /sec_met_domain="adh_short (E-value: 3.1e-29, bitscore:
                     100.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 5.3e-32, bitscore:
                     110.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQDSGKVALVTGASRGIGYGIAEALVARGDRVAITGRGEDALK
                     EAVERLGADRVIAIPGKAHDEAHQAAAVERTMEAFGRVDYLVNNAGTNPVFGPMAELDL
                     NVARKVYETNVISALGFAQQTWKAWQKENGGAIVNIASVAGVAPSPFIGAYGMSKAAMI
                     NLTAQLAHEFAPVVRVNAIAPAVVKTKFAEALYEGREAEAAAAYPLGRLGVPEDIGGAA
                     AFLTSAQSDWITGQTLVVDGGIFLNAGVG"
     aSDomain        complement(3637..4128)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CCZ36_RS03340_PKS_KR.1"
                     /evalue="1.40E-08"
                     /label="CCZ36_RS03340_PKS_KR.1"
                     /locus_tag="CCZ36_RS03340"
                     /protein_end="172"
                     /protein_start="8"
                     /score="26.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGASRGIGYGIAEALVARGDRVAITGRGEDALKEAVERLGA
                     DRVIAIPGKAHDEAHQAAAVERTMEAFGRVDYLVNNAGTNPVFGPMAELDLNVARKVYE
                     TNVISALGFAQQTWKAWQKENGGAIVNIASVAGVAPSPFIGAYGMSKAAMINLTAQLAH
                     E"
     CDS_motif       complement(4036..4122)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CCZ36_RS03340_0001"
                     /evalue="4.10E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="CCZ36_RS03340"
                     /protein_end="39"
                     /protein_start="10"
                     /score="13.0"
                     /tool="antismash"
                     /translation="LVTGASRGIGYGIAEALVARGDRVAITGR"
     gene            complement(4173..4934)
                     /gene="fabG"
                     /locus_tag="CCZ36_RS03345"
     CDS             complement(4173..4934)
                     /EC_number="1.1.1.100"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-167). E-value: 3e-19. Score:
                     61.6. Matches aSDomain:
                     nrpspksdomains_CCZ36_RS03345_PKS_KR.1"
                     /codon_start=1
                     /gene="fabG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262869.1"
                     /locus_tag="CCZ36_RS03345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-oxoacyl-ACP reductase FabG"
                     /protein_id="WP_006122981.1"
                     /sec_met_domain="adh_short (E-value: 2.5e-35, bitscore:
                     120.7, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTEQRVAIVTGAARGIGAATAVRLAAEGRAVAVLDLDEAACKD
                     TVEKITAAGGTALAVGCDVSDAGQVEAAVARVAAELGAPTILVNNAGVLRDNLLFKMSE
                     SDWDIVMNVHLKGAFLMAKAVQAHMVEAKFGRIVSLSSSSALGNRGQANYSAVKAGLQG
                     LTKTLAKELGKFGVTANAVAPGFIVTEMTAQTAERVGMGFEEFQAAAATQIPVQRVGRP
                     EDVANAIAFFAGDDAGFVSGQVMYVAGGPLN"
     aSDomain        complement(4434..4913)
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CCZ36_RS03345_PKS_KR.1"
                     /evalue="3.00E-19"
                     /label="CCZ36_RS03345_PKS_KR.1"
                     /locus_tag="CCZ36_RS03345"
                     /protein_end="167"
                     /protein_start="7"
                     /score="61.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAIVTGAARGIGAATAVRLAAEGRAVAVLDLDEAACKDTVEKITA
                     AGGTALAVGCDVSDAGQVEAAVARVAAELGAPTILVNNAGVLRDNLLFKMSESDWDIVM
                     NVHLKGAFLMAKAVQAHMVEAKFGRIVSLSSSSALGNRGQANYSAVKAGLQGLTKT"
     CDS_motif       complement(4839..4907)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CCZ36_RS03345_0001"
                     /evalue="1.60E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="CCZ36_RS03345"
                     /protein_end="32"
                     /protein_start="9"
                     /score="11.1"
                     /tool="antismash"
                     /translation="IVTGAARGIGAATAVRLAAEGRA"
     gene            complement(5174..5557)
                     /locus_tag="CCZ36_RS03350"
     CDS             complement(5174..5557)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451004.1"
                     /locus_tag="CCZ36_RS03350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3037 domain-containing protein"
                     /protein_id="WP_010062244.1"
                     /transl_table=11
                     /translation="MTRRDVFEYALLRVVPRVERGECFNAGVLVYCRAHSFVAARTYLD
                     EAKLKALDPDADVVGVRAALRAVEGVCGGGAEAGQAAGDDAGRRFRWLIAPRSTVVQPG
                     AVHSGLTTDPAGEVERLLDLLVR"
     gene            complement(5554..6435)
                     /locus_tag="CCZ36_RS03355"
     CDS             complement(5554..6435)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122983.1"
                     /locus_tag="CCZ36_RS03355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HipA family kinase"
                     /protein_id="WP_079134299.1"
                     /transl_table=11
                     /translation="MLQEVVATRYVTPLREGGSLPGIVEADDLGTYVMKFTGAGQGRKT
                     LVAEIICGELGRRLGLRVPELVTIELDPVIGLAEPDQEVQELLKASGGLNLGMDYLPGS
                     FGFDPLAYEVGAAEAGRVVWFDALINNVDRSWRNPNLLVWHGDLWLIDHGATMIWHHNW
                     PGAQASAAKPYNASDHVLAPFGPDIAAAAAELAPLVTEELLTEVAADVPDVWLAGEPGF
                     DSADEVRRAYVAPLLARAATIHERITLDAPTAARPSQAPGWLTDRLPPRRKRAADDDRA
                     AAAARTGEEGGR"
     gene            complement(6567..7811)
                     /locus_tag="CCZ36_RS03365"
     CDS             complement(6567..7811)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070062.1"
                     /locus_tag="CCZ36_RS03365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_069736089.1"
                     /sec_met_domain="ATP-grasp (E-value: 3.2e-08, bitscore:
                     32.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPANESPAVLLLDPVRTGAHYKTEARRRGFSTISVYTVAQEVIAE
                     NWPDHADGDDVSVYSADADEILTRIDSLGVQLIGVVPAMDSAVHLADTLAERLSLPGNG
                     LAKAAARRNKADMRRVAAEAGLRIPRFVLVDSTAKIAAAASEIGFPAIAKHTTGAGSYG
                     TYLLSSPEDAARTSTMHAKNQFGWQVDEWLVEQYIRGRELAVNCFSHNGEHRIVDIWEY
                     RQPDDSDYDFPYWESAKLPEDDPDYQAAADYVRAALTAFDVRLGPSHTEVKVGPDGVHL
                     MEVGARLPGGPMTDQWLAHTDLNPFEQALDCYLGVRPACLDAPVRFRQSCGASAIRNDG
                     PAGTLREIRGLDEVRKMPGVDKVLSIYEPGDHVPITDNTLNIPIGVWVSAPDHAGVVEL
                     LARVRDTVELVIDET"
     gene            complement(7890..8891)
                     /locus_tag="CCZ36_RS03370"
     CDS             complement(7890..8891)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (116-304). E-value: 1e-18. Score:
                     60.0. Matches aSDomain:
                     nrpspksdomains_CCZ36_RS03370_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070063.1"
                     /locus_tag="CCZ36_RS03370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_128817003.1"
                     /sec_met_domain="TauD (E-value: 1.2e-16, bitscore: 60.0,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALAVREKHVAQPALRLTRDEAGTLWELSEKSAGLLDPPHSSDLS
                     EFLPDVPAHLRDALVDFREGTASSGYLLVKGVATGDIPDTPLAYGTRALVGHASNGTLA
                     LVGDVLGSLIGYADEKNGDLLHDVHPVRGEEHRMENSGSVAFDFHTENVHHPLRPDFLG
                     LLSLRQGHEATATRVASIRHAVAHLSEDENAVLRRLRFRSLFPTSFTRGLTGERPATAE
                     HRVLFGDPGYEFLRFDSFNTKPADLEAERALGALAEALEAVCVEVVLEPGDLLLVNNHI
                     AAHGRSAFTPRYDGRDRWLRRFYSHRAVPGWARLMMPNKRVLPATGDIQGIF"
     aSDomain        complement(7980..8543)
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CCZ36_RS03370_TauD.1"
                     /evalue="1.00E-18"
                     /label="CCZ36_RS03370_TauD.1"
                     /locus_tag="CCZ36_RS03370"
                     /protein_end="304"
                     /protein_start="116"
                     /score="60.0"
                     /tool="antismash"
                     /translation="ADEKNGDLLHDVHPVRGEEHRMENSGSVAFDFHTENVHHPLRPDF
                     LGLLSLRQGHEATATRVASIRHAVAHLSEDENAVLRRLRFRSLFPTSFTRGLTGERPAT
                     AEHRVLFGDPGYEFLRFDSFNTKPADLEAERALGALAEALEAVCVEVVLEPGDLLLVNN
                     HIAAHGRSAFTPRYDGRDRWLRRFY"
     gene            complement(8906..9937)
                     /locus_tag="CCZ36_RS03375"
     CDS             complement(8906..9937)
                     /EC_number="1.14.19.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016717 - oxidoreductase activity, acting
                     on paired donors, with oxidation of a pair of donors
                     resulting in the reduction of molecular oxygen to two
                     molecules of water [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070064.1"
                     /locus_tag="CCZ36_RS03375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="fatty acid desaturase family protein"
                     /protein_id="WP_237302589.1"
                     /transl_table=11
                     /translation="MSEKDQLTVRPYAKGYTAPSRLRLDIKDAHRTRLWVTTSCALLDH
                     LVVGLMAAGAAWLIVNHPLASIVPALLAGVVIARQLRALENLVHEASHYNWSRHRRRLN
                     DVLGYLLAAAPTGSRISAYRTSHLLHHGRFGTAEDPDRYRYAELDMEALPRTSARLFVA
                     GVCTRLLRYQLGWLRELRTNALAPLVALLWSVLCVGAPTALLLDLRTGAVAAGVWLFAH
                     FLLLPPLRLVAEADEHVYSDARTVFDATVSNTGRLQRWLFHPHADGYHTVHHMWPGIPH
                     HSLSRIHHLLLSEDEEFARRLRTRDRILTTPGGVAPGGPAREAATPRAPTSPPPSLKIK
                     SSL"
     gene            complement(10001..10600)
                     /gene="folE"
                     /locus_tag="CCZ36_RS03380"
     CDS             complement(10001..10600)
                     /EC_number="3.5.4.16"
                     /codon_start=1
                     /gene="folE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: GTP_cyclohydroI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070065.1"
                     /locus_tag="CCZ36_RS03380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="WP_237302590.1"
                     /sec_met_domain="GTP_cyclohydroI (E-value: 1e-50, bitscore:
                     170.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIDMDASAITILEQDEVQGGDPLESIARRLLIEIGEDPDREGLR
                     DTPRRYARWWREFVDYDAGNLDTVFSSVASNQTVMVSGMRVWSLCEHHLLPFNCDLQVA
                     YRAHDSLLGLSKFARIAHKHAHKLQVQERLVADIAAEIEEITKSPDVAVIGRGEHLCMT
                     MRGIKTGAQMTSAVFQGVFRENSFERTELLSLMNGS"
     gene            complement(10601..11308)
                     /locus_tag="CCZ36_RS03385"
     CDS             complement(10601..11308)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070066.1"
                     /locus_tag="CCZ36_RS03385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="7-carboxy-7-deazaguanine synthase QueE"
                     /protein_id="WP_237302591.1"
                     /sec_met_domain="QueE (E-value: 6.3e-79, bitscore: 263.4,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 8e-12, bitscore: 44.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.1e-12, bitscore: 45.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIVVNEIFGPTVQGEGPSAGRQCAFLRLGGCNLSCHWCDTPYTW
                     DWKGTSDEKTAFDPRKELHNRDVDEVVDELLALGTDLVVISGGEPLSQQRRLRPVLKRL
                     LDAGVTVEFETNGTVAPDDEIITPGVRFNVSPKLAHAGDPASKRIVPAALSKLAQTPDV
                     AFKFVCRTTDDLDEVAVLQADFGISPIWIMPEGKSVAHISQHLSSLADEVVRRGWNLST
                     RLHVLAWGDKRGI"
     gene            complement(11305..11667)
                     /gene="queD"
                     /locus_tag="CCZ36_RS03390"
     CDS             complement(11305..11667)
                     /EC_number="4.1.2.50"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="queD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: PTPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019433797.1"
                     /locus_tag="CCZ36_RS03390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="6-carboxytetrahydropterin synthase QueD"
                     /protein_id="WP_010070067.1"
                     /sec_met_domain="PTPS (E-value: 1.2e-33, bitscore: 114.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLHITKEFHFSASHRLEHLPSDHQCARLHGHNYIIELKLSAAPDQ
                     LTEPGFVRDYGDLADFKKWLDHTLDHRHLNDIIEDRNPSAENMAMWIYDQWTERYPELS
                     AVRVSETDKTWAEYRP"
     gene            complement(11672..12343)
                     /gene="queC"
                     /locus_tag="CCZ36_RS03395"
     CDS             complement(11672..12343)
                     /EC_number="6.3.4.20"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="queC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: QueC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070068.1"
                     /locus_tag="CCZ36_RS03395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="7-cyano-7-deazaguanine synthase QueC"
                     /protein_id="WP_069736088.1"
                     /sec_met_domain="Asn_synthase (E-value: 2.2e-08, bitscore:
                     32.8, seeds: 78, tool: rule-based-clusters)"
                     /sec_met_domain="QueC (E-value: 3.8e-57, bitscore: 191.8,
                     seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARVIAIVSGGLDSVVLAHHLHAEGHEVHLLSIDYGQRHRKEHDY
                     ARIAADRIGAEHEIVDLSNVASMLPGYSLTDSQVDVPDQHYTAPGSVNVVPNRNVILLS
                     VAYGKAAAVKADQVAIGALAGDASTAPDCSAEFISSFNAMEKIACAGYAPAHLEVVAPF
                     IDLHKHDVIRLGEKLGVDWAETWSCFKGTEVHCGTCAACVDRIQAFERAETTDPTVYFK
                     E"
     gene            complement(12576..13589)
                     /locus_tag="CCZ36_RS03400"
     CDS             complement(12576..13589)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014805.4"
                     /locus_tag="CCZ36_RS03400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_237302592.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.1e-10, bitscore:
                     40.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 4.3e-06,
                     bitscore: 25.0, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGVLCYDEIRVPIAARMAEELKLPTANAEGVLACRDKHLGRQAL
                     AAAGVAQPVSRAVASLEEAREAAGAIGYPVVLKPRALAASVGVVRADGPEALDSAYSEA
                     AAAYFDEIPRDRAWVLVEEYLDGPEVSVESVCHNGRVTPMFVARKALGFAPHFEEVGHT
                     VSADDPLLHDPEVRRVLQEAHTALGLDTLVTHTELRLTRTGPRLVEVNARLGGDLIPYA
                     ARLATGVDYGMVAADLAAGGRPDVAPVRTASAHVEFLYPEHDLDVTSLTVEEELPAGVH
                     EVTPMAEPGRRLRLPPRDHVAGRYAYVVTTGVSPQECADALRAATPLVRLVGTPVD"
     misc_feature    13738..13753
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.1"
                     /tool="antismash"
     misc_feature    complement(13853..13863)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    complement(13873..13884)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.92"
                     /tool="antismash"
     gene            complement(14029..15021)
                     /locus_tag="CCZ36_RS03405"
     CDS             complement(14029..15021)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122992.1"
                     /locus_tag="CCZ36_RS03405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_237302593.1"
                     /transl_table=11
                     /translation="MDMHLSTDMRRAYALAVRRRALTAEVVAEELGLDASEADRVIAGL
                     VELRLLQQDAGGDLFAAVAPDSAQLRLLGPLVREISVMQEKADRIRADLGSLLPVYWDE
                     VESAAGQIEVVRDLDVVLTLIEEFSARATTEVLTSQPGGGRPVKQLETALTFAQELLER
                     GVRMRTLYQHTAQFHQGTAAYVEHVAPLGGEVRTTASGFPRMLVFDRRVAVLALKGHPE
                     GALVLRNENVIDVLVDTFERTWVGARPFPLSYSKGQIVHVSSEVKDTIMRLLVVGESDK
                     KIAARVGLSLRTCQRHIADLMQEIGARNRLHAGYLLHEQLAKSDAGGVT"
     misc_feature    15390..15405
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     misc_feature    complement(15409..15424)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.16"
                     /tool="antismash"
     gene            15520..15699
                     /locus_tag="CCZ36_RS03410"
     CDS             15520..15699
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122994.1"
                     /locus_tag="CCZ36_RS03410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_069736086.1"
                     /transl_table=11
                     /translation="MRLVTEILKSSLLAATLLGLAGPTIDASNRSTQADTRANSASCGH
                     ACPNNAPGADLGWG"
     gene            15819..17066
                     /locus_tag="CCZ36_RS03415"
     CDS             15819..17066
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122995.1"
                     /locus_tag="CCZ36_RS03415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_128817004.1"
                     /sec_met_domain="ATP-grasp (E-value: 7.2e-07, bitscore:
                     27.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.8e-11, bitscore:
                     42.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLHTRRRPVGSVLLLGGTRPEPVRAAKAAGLSITYLGAAARTPRD
                     ILDNADGCLLLEDPTPENMTEAARKLHAEKSFGVVVTMVDRYLEAAALLNAEFGLPANT
                     VDTVRSMNDKHRMRAAALHSACAPVAHAAVRTAEDLRSFAGRHGYPFILKPVDGSASRG
                     VALVSDAATLESAARAMTGSAAPESRWIAEEFLSGPEFSVETFSTDGSHHVVAVTEKFK
                     GDNFVEIGHLVPARVRAADHAAMAAEVGALLDAVGLNEGVAHTEVVLTDAGPRVVETHS
                     RPGGDGIVELVRLAKGVDLQQMTFDWFAGKPVDPLLAPAARASATWSLTPPEGTVTAVS
                     GLDEALRHEGVTEGYTVLEPGDTVRPLRSSDDRSGAVITVAPGPDAALARARAAVDLID
                     VTVVPAGVDLGGPVPR"
     gene            17063..18292
                     /locus_tag="CCZ36_RS03420"
     CDS             17063..18292
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122996.1"
                     /locus_tag="CCZ36_RS03420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_128817005.1"
                     /transl_table=11
                     /translation="MSGERSYGYRVLFSEPGILVYALAAAFGKLQAGMFALGTLYAVAD
                     QRSYSAGAFVVAVSALGGLSTPLRGRLLDRYSYGPVLWTIMAIHTVLVGGLLVNEHRGG
                     PFWVTVASGLLGNLAAPPIGVVTRVMWRSVTTEKSRPTALAFDSVLADAGFILGPALAA
                     LVCATLAPWAGLAAVLFFTAVAMLLLPKNIGDDKTSARQGDRHWAGPLTSPRLVLLLGA
                     ALCFATSVSVLEIALATPHGDGDSKVLSGLLVSVLATGSIVGGLLIGAMTPELAKRATR
                     LPVLLMSLAVFSTALAFGNKAGWLVAVPLCLLTGLSFGPSFVAVYGRSGDLAPAGMAAE
                     TQAWAGTALQLGSAAGAGAGGVLLDIWGPPGALALAPIAAVIGAASAFAGDRLRTPVAE
                     PRGDAIPESL"
     gene            complement(18440..19138)
                     /locus_tag="CCZ36_RS03425"
     CDS             complement(18440..19138)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123000.1"
                     /locus_tag="CCZ36_RS03425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phenylalanine--tRNA ligase beta subunit-related
                     protein"
                     /protein_id="WP_128817006.1"
                     /transl_table=11
                     /translation="MTFQLTVADEVYTLAPTFTHVAIEAYDLVNGPSSEESSAFLDEAA
                     RRLAVRLDGRAPHEDPHVASWRETYTAFGSKPSRTRNSAEALAKRALSDAGLPRINLLV
                     DLYNAISVAHLIPVGGEDLDLIEGGMRLVRAEGDEDFVTVTGGERTVEHPDAGEVVWCD
                     DAGVTCRRWNWRQGPRTRLTEETTSGLFLLEGLAPMPVAELETAAAELAEALAKFSPSA
                     RIEVHAPVSA"
     gene            19413..20412
                     /locus_tag="CCZ36_RS03430"
                     /pseudo=""
     CDS             19413..20412
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070090.1"
                     /locus_tag="CCZ36_RS03430"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLRIHFTPRT"
     gene            20566..21279
                     /locus_tag="CCZ36_RS03435"
     CDS             20566..21279
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468596.1"
                     /locus_tag="CCZ36_RS03435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="C39 family peptidase"
                     /protein_id="WP_128817007.1"
                     /transl_table=11
                     /translation="MRARLVPGTIAALAIGALLLPGTAEASPAPAVPVVDVRAHDSTSG
                     TALASGYGKPGTRLRVDAGRSSNARWLEIDYQVQQTGYWCGPAATRIALSARTAAPSQG
                     ELAAQLGTTEAGTDHIGQITAVLNARLGSGWYETKEMPNDPPTQAQRDLLWHDIVFDID
                     RNYPLVANIVAPPGNQPPGYPPDQTIYHYFTVFGYDAVDRTVLIADPASFGGNQIYWIS
                     FDQLATLIPPKGYSA"
     gene            21327..22316
                     /locus_tag="CCZ36_RS03440"
     CDS             21327..22316
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1104: putative esterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468390.1"
                     /locus_tag="CCZ36_RS03440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="esterase family protein"
                     /protein_id="WP_128817008.1"
                     /transl_table=11
                     /translation="MSTQRPTRRGVLKAAAGISATTALGAGGVLASASAAHAVGDGFGL
                     RIVDRDERDPRMRYFRFATDAIGWNPGVNVLLPDGYHSGGRRYPVLYLFHGGGTGQDFI
                     TFDRMGIRAWTAGKPLIVVMPDGGAAGWYSNPVVSNVGPRNWETFHIGQLLPWVDANFR
                     TYAEYDGRAVSGFSMGGFGALKYAAKYYGHFASASSHSGPASLRRDAGLVTHWANLSSA
                     AVELGGGTVYGAPLWDEARVSADNPVQRVGSYRNKRVFLVAGTSPDPVNWFDTVNETQV
                     LAGQREFRGTLGAAGIPHEFHEVPGGHFVRPDLFRRDLDGIVARLRKA"
ORIGIN
        1 agccggccgc cgcccgaccg gccgtcctcc cccgcgcccc cggccgtcgg ctccgcggag
       61 gcccggcgcg gcggaccggc gggggtcgcc cggccgcccg agcgcgcgga ccggccgcag
      121 cgacgggccc ccgaccgggc cccgagggtc ccgtccgtca ccgtgcccgc cctgccacgc
      181 ctccccggcg gcggtgcgga cgtctgtgcg ctcggccggg ggtacggcgg ctggcccgcg
      241 ggcagcccgc aggcccgcat ctgctcggag acgtacggcc actgacgctg ctgcccccgg
      301 aggccctggt ccccgggggt cactggtccc gcaggcggag ctccaggcgg tcgatggcgg
      361 cgcggacccc gtcgccgtac ccgtcgtccg ggagcgatgc ggcggcggcg cgggctcgtt
      421 ggaggtggat gcgggcggag tcggggcgct ggagcttgag gtagtccgcc gcgaggttga
      481 ggtgcagcga ggggtagaac gcccggacgg ccggaaggtc cgggtgctgc gccgaccgcc
      541 caccgcccgc cccctcggca gccgtcaggg cccgcaggtc ccaggccagc tcgtcgccgg
      601 ggtcgtcctg ggtgtcggcc atgtagtgcg cgagggtgca gcggtgcagg gcgtcgccgt
      661 ccgctccgag ctccgaccag agcgcaccga agcggttgcg ggcctcctcc cggtcacctc
      721 cgtggagcag catgatcgcc tggccgatcc tggtcatgac ggcgtcctcg gacgtctcct
      781 gccgctccac cactgctgtc tcctcgtcgc ccgtccaacc ggtcgcccct gtccgtccga
      841 cgctaacggc aggcttgcgc agaaccggtc agacacgggc gcggcgggtg cccctgccgg
      901 gggaacccgt cagccgaggt cggggatccg ccagtcgatc ggctggtgcc cctgggcggc
      961 cacggcctcg ttgatctgcg tgaaggggcg ggagccgaag aacttcttgg cggacagcgg
     1021 cgaggggtgt gcgcccttca ccacgatgtg gcgctcctcg tcgatcaagg gcagcttctt
     1081 ctgcgcgtaa ttgccccaga gcacgaagac cgccggatcg ggccggtccg cgacggcgcg
     1141 gatcacggcg tcggtgatct tctcccagcc cttgttcttg tgggagttgg cctcgccgcc
     1201 ccggacggtc agcacggcgt tgagcaggag cacgccctgt tcggcccagg gcatcagata
     1261 accgttgtcc gggatgggca ggcccagctc ctgctgcatc tccttgtaga tgttgcgcag
     1321 ggacggcggc gtcctgacgc cgggccgcac ggagaagcag agcccgtgcc cctggcccgc
     1381 gccgtgatac gggtcctggc cgaggacgag gaccttcacc ttgtcgtaag gcgtggcgtc
     1441 cagcgcggcg aagacctgct cgcggggcgg gtacacggga cccttggccc gctcctcctc
     1501 gacgaagtcc gccagctcct tgacgtacgg cttctgcagt tcttcgccga ggacgccgcg
     1561 ccaggactcg ggcagcaggt cgatatcggt cacgtccaca acctccggtg agcaacaggt
     1621 tcttggtccc agaacctacc ggtcaccact gacaacgggc ccccgaggag gcccgtcgtc
     1681 ccttcatcgc cggtctgcta ccagctggcc ttgcggtaca gctcccacag ctgcatgacc
     1741 gtctgcgggt cgagtgcccg ctcgccgccg ccgatgtcct cgcccgcggc gatgtacagc
     1801 ttgccctgcc acagcggcag caggcggacg tcgtcgacca ggatctcctg ggcccgctcg
     1861 aactgcttgc tgaccgcgcc ccggtcgctc tcctgccgcg aggcggggat cagctgctgg
     1921 gtgatctcct tgttgatgta cgggctgccg gtgacgggct cctggcccac gaacggggcg
     1981 acgaagttgt cggggtccgg gaagtcgggg aaccagccgc ggccgaagac cgggtactcg
     2041 cccttgttga agccttcctg gaacttctgc cagggctcgc cccgcagcgt gatcttgaac
     2101 agtccggagg cctccagctg ccgcttgagc tcctggaact cgggctccgt ggcggagccg
     2161 tagcggtcgg tggtgtacca gaaggtcatc ttcacgggct cggtgatgcc tgccccggag
     2221 aggatgctct tcgccttgtc cgcatccgga tcgccgaagg tgtcgaagaa gctcgtggtg
     2281 tgtccggcga tgcccttggg gatcatggag tagaggggct cggcggtgcc ccggtagacc
     2341 ttggcgacca gcgcgtcgcg gtccacgaca tgggcgatgg ccttgcggac ggcggggttc
     2401 gcggcggccg ggtccttcgg gttgaagacc aggaagcgga tgtccgcgcc cgtgctctcg
     2461 acgatctgga ggccggcgtt gtcgtccttg ttgtcctcca ggctgacgac ctcctcggcg
     2521 gtcagaccgc ggtaggtggc gtcgatctcg tcggccttga gcgcgctcac catgtccgcg
     2581 gacttctcga agtagcggat ggtgaccgcg tcgttcttcc gcttggcgaa gccgttgtag
     2641 tccgggttct tcttcagctc ggcggtcttc ccgccctcgt aggactccag gaggtacggg
     2701 ccggagccgg tgaccttgcc gtcgtcgcgg atcttgtcct tgcggtagtc gccgggggcg
     2761 acgagcgaca tggcgggcgt ggccaggatg aacgggaacg tggcgtcgga cttgttcagg
     2821 tggaagacga ccgtgtcctc gcccttggtc tcgatccggt ccagcgagcc gagcatcccg
     2881 gccgggccgc ccttgaagtg gatgtccacg atgcggtcga tggagtactt cacggcctcg
     2941 gcgtcgagct tctcgccgtt ggagaacttg aggttcttct tgagcgtgca ccggtacgcc
     3001 atgctcgtgg cgtcggtgaa cttgcaggat tccgccgcgt caggctccgg gctcgtgctg
     3061 ccggtgggga agctcaccag ggtctggtaa acgttccgca tcaattccca ggatccgtcc
     3121 caggccgccg ccggatcgag cgtggacggg gaactggtcg taccgacggt tatcttctgg
     3181 tccgtttccg atccgctgtc ggaaaggaga ccgcagccgg ccagcagaga aagggaagct
     3241 agggctgcag cagcctgcag actggcccgg tagaacacgt gcacgctcct cgatcagcca
     3301 tgggtcggca gaccataccg cagcgcccca ccaggtcaat ccggtggccc ggcggggcac
     3361 ttgactcaat cagggccaaa tcggttcagg ccgctctcag cccacacccg cgttgaggaa
     3421 aattcctccg tcgaccacga gggtctgtcc ggtgatccag tcggactgtg ccgaggtcag
     3481 gaaggcggcc gcgcctccga tgtcctcggg cacgccgagc cggcccagcg gataggcggc
     3541 ggccgcctcc gcctcgcggc cctcgtagag cgcctcggcg aacttcgtct tgaccacggc
     3601 cggggcgatc gcgttgaccc ggacgaccgg ggcgaactcg tgcgccagct gggcggtcag
     3661 gttgatcatg gccgccttcg acatgccgta cgcgccgatg aacggcgagg gggcgacgcc
     3721 ggcgacggag gcgatgttga cgatcgcccc gccgttctcc ttctgccagg ccttccaggt
     3781 ctgctgggcg aagccgagcg ccgagatcac attggtctcg tagaccttgc gggccacatt
     3841 gaggtcgagt tcggccatcg ggccgaagac cgggttggtc cccgcgttgt tcaccaggta
     3901 gtcgacccgg ccgaacgcct ccatggtccg ctcgaccgcc gccgcctgat gggcctcgtc
     3961 gtgcgccttg ccggggatcg cgatgacccg gtcggcgccg agccgctcca cggcctcctt
     4021 gagggcgtcc tcgccccgcc cggtgatggc gacccggtcc ccgcgggcga cgagcgcctc
     4081 ggcgatcccg tagccgatgc cccggctggc gcccgtgacg agggcgacct ttccgctgtc
     4141 ctgcaccgtc atgttgtccg ctgcccttcg gatcagttga ggggtccgcc ggccacgtac
     4201 atgacctggc cggagacgaa gcccgcgtcg tcgcccgcga agaaggcgat ggcgttcgcg
     4261 acgtcctcgg gacggccgac gcgctggacg gggatctggg tggcggccgc cgcctggaac
     4321 tcctcgaagc ccatgccgac gcgctcggcg gtctgcgcgg tcatctcggt gacgatgaat
     4381 ccgggcgcga cggcgttggc ggtgacgccg aacttgccga gctccttggc gagggtcttg
     4441 gtgaggccct ggaggcccgc cttgactgcg gagtagttgg cctggccccg gttgccgagg
     4501 gccgaggagg aggagagcga gacgatccgg ccgaacttgg cctcgaccat gtgggcctgg
     4561 acggccttcg ccatcaggaa cgcgcccttg aggtgcacgt tcatcacgat gtcccagtcg
     4621 gactcgctca tcttgaacag caggttgtca cggagcacgc cggcgttgtt cacgaggatc
     4681 gtcggcgcgc ccagctcggc ggcgacccgc gcgacggcgg cctccacctg accggcgtcc
     4741 gacacgtcgc agccgacggc cagcgcggtg cccccggcgg cggtgatctt ctcgaccgtg
     4801 tccttgcagg ccgcctcgtc gagatcgagt acggcgacgg cgcggccctc ggccgcgagg
     4861 cgtacggcgg tggcggcgcc gatgccccgc gccgctcccg tcacgatggc gacgcgctgc
     4921 tcggtggtgg acatgcttgg ttctcctcgc ccttggatag cggcccagcc gacatcgggg
     4981 cacttccccg ccagtccctg acactccctg gcagcaagac cctcgattgc tgagcaaccg
     5041 cttagtacct tcagcagacg tgacgctaga agccctggca cccggtgtca acggcgcacg
     5101 ccccggcggg ccgtacgtca caccgggcgg gagcgtccgc cgctgtgccg tcgtggtccc
     5161 accggggcgc ggatcagcgc acgaggaggt cgagcagccg ttccacctca ccggccgggt
     5221 cggtggtcag cccgctgtgc acggccccgg gctggaccac cgtggagcgc ggggcgatca
     5281 gccagcggaa ccgccgtccg gcgtcgtcgc ccgccgcctg gcccgcctcc gcaccgccgc
     5341 cgcagacccc ttcgacggcg cgcagggcgg cccgcacccc gaccacgtcg gcgtccgggt
     5401 ccagcgcctt cagcttcgcc tcgtcgaggt acgtccgggc cgccacgaac gagtgggccc
     5461 ggcagtagac gagcaccccg gcgttgaagc actccccccg ctcgacccgg ggcacgacgc
     5521 gcaggagcgc gtactcgaag acatcgcgcc gcgtcatcgg ccgccctcct cgccggtacg
     5581 ggcggccgcc gcggcgcggt cgtcgtccgc ggcccgcttc cgccggggcg gcagccggtc
     5641 cgtgagccag cccggggcct gggagggccg ggccgcggtg ggcgcgtcca gtgtgatccg
     5701 ctcgtggatg gtcgcggccc gcgcgagcag cggggcgaca taggcccggc gcacctcgtc
     5761 ggcggagtcg aaaccgggct cgccggccag ccagacgtcc ggcacatcgg cggcgacctc
     5821 ggtgagcagc tcctcggtga ccagcggggc gagctcggcg gcggcggccg cgatgtcggg
     5881 cccgaagggg gccaggacat ggtcggaggc gttgtacggc ttggcggcgg aggcctgggc
     5941 gcccggccag ttgtggtgcc agatcatggt cgcgccgtgg tcgatcagcc agaggtcgcc
     6001 gtgccagacg agcaggttgg ggttgcgcca ggaacggtcc acgttgttga tcagcgcgtc
     6061 gaaccagacg acccgcccgg cctcggccgc cccgacctcg taggcgagcg gatcgaaccc
     6121 gaacgagccc ggcaggtagt ccatgccgag attcaggccg ccgctcgcct tgagcagctc
     6181 ctgcacctcc tggtccggct ccgccagtcc gatgaccggg tccagctcga tggtcaccag
     6241 ctccggcacc cgcagcccga gccggcggcc gagctccccg cagatgatct cggcgacgag
     6301 ggtcttgcgg ccctgtccgg ccccggtgaa cttcatgacg tacgtaccga gatcgtcggc
     6361 ctcgacgatg ccggggagcg agccgccctc acgcagaggc gtgacatagc gggtcgctac
     6421 gacctcttgc aacactttcc cgtcccttgc tgcccgcttc cggcatgaag tgagcatagt
     6481 aaccgggggt gatcgcaggc gaggatcgcc tcgtcctccg cgggtggacg aggcgatccc
     6541 gcgtcggccg gtcgaccggc tcgttctcag gtttcgtcga tgaccagctc gaccgtgtcc
     6601 cggacgcggg cgagcagctc caccacgccc gcgtggtccg gagcggacac ccagactccg
     6661 atcgggatgt tgagggtgtt gtcggtgatc ggcacgtggt cccccggctc gtagatcgac
     6721 agcaccttgt cgacacccgg catcttccgg acctcgtcga ggccacggat ctcccggagg
     6781 gtgcccgccg gaccgtcgtt gcggatggcg ctggcaccgc aggactgccg gaagcgcacg
     6841 ggcgcgtcca gacaggcggg ccggacaccg aggtagcagt cgagtgcctg ctcgaacggg
     6901 ttcaggtcgg tgtgcgcgag ccactggtcc gtcatcgggc caccgggaag ccgcgcgccg
     6961 acctccatga gatgcacgcc gtcggggccg accttcacct cggtgtggct ggggcccagc
     7021 cgcacgtcga acgccgtgag agcggcgcgt acgtagtcgg cggcggcctg gtagtccgga
     7081 tcgtcctcgg gcagcttggc cgactcccag tacgggaagt cgtagtcgct gtcgtcgggc
     7141 tgccggtatt cccagatgtc gacgatgcgg tgctcgccgt tgtggctgaa gcagttcacc
     7201 gccagctcgc gcccgcggat gtactgctcg acgagccact cgtcgacctg ccagccgaac
     7261 tggttcttcg cgtgcatcgt ggatgtccgg gccgcgtcct cggggctgct cagcaggtac
     7321 gtgccgtacg agccggcccc cgtggtgtgc ttggcgatgg ccggaaagcc gatctccgag
     7381 gcggccgcgg cgatcttggc ggtgctgtcc acgagaacga accgcgggat gcgcaggccg
     7441 gcttcggccg cgacccggcg catgtccgcc ttgttccggc gcgcggccgc cttggcgagg
     7501 ccgttgccgg gcagcgacag ccgctccgcc agggtgtcgg ccaggtgcac cgccgagtcc
     7561 atggccggga ccacaccgat gagttgcaca ccgagcgagt cgatccgggt gaggatctcg
     7621 tcggcgtcgg ctgagtagac gctgacgtcg tcgccgtccg cgtgatcggg ccagttctcc
     7681 gcgatcacct cctgggccac cgtgtacacg gagatcgtcg agaagccgcg ccggcgtgcc
     7741 tcggtcttgt aatgggcacc ggtacggacc gggtccagaa gcagaacggc tggcgattca
     7801 ttggcaggca tgagtggggc gaactcctgt gaggcagagg aaggttcggc gggtgggcgc
     7861 ccgcctgcgg tgatggggcg gccggcgggt cagaagatgc cctggatgtc ccccgtcgcg
     7921 ggcaggaccc gcttgttcgg catcatcaga cgcgcccagc ccggcaccgc acgatgcgag
     7981 tagaagcggc gcagccagcg gtcgcgcccg tcgtagcggg gggtgaaggc ggaccgcccg
     8041 tgggccgcga tgtggttgtt gacgagcagc aggtcaccgg gctccaggac gacctcgacg
     8101 cagacggcct ccagggcctc ggccagtgcc cccagggccc gctcggcctc gaggtcggcc
     8161 ggcttggtgt tgaacgagtc gaaacggagg aactcgtagc cgggatcgcc gaagaggacc
     8221 cggtgctccg ccgtcgcggg ccgctcgccg gtcaggcccc gggtgaacga ggtcgggaac
     8281 aggctccgga accgcagccg tcgcagcacg gcgttctcgt cctcggacag gtgggccacg
     8341 gcgtgcctga tggaggcgac gcgggtcgcc gtggcttcgt gcccctgccg caggctcagc
     8401 agtccgagga aatccggccg cagggggtgg tggacgttct cggtgtggaa gtcgaaggcg
     8461 acggagccgc tgttctccat ccggtgctcc tccccgcgca ccgggtgcac gtcgtggagg
     8521 aggtcgccgt tcttctcgtc ggcgtagccg atgagactgc ccagtacgtc ccccaccagg
     8581 gcgagcgtgc cgttgctggc gtgtccgacg agcgcccgcg tcccgtaggc gagtggtgtg
     8641 tcggggatgt cgccggtggc cacccccttg acgagcaggt atccgctgct cgcggtgccc
     8701 tcgcggaagt ccaccagtgc gtcgcgcagg tgagcgggga catcggggag gaactccgac
     8761 agatcggagg agtgcggggg gtcaagaagc ccggccgact tctccgacag ctcccacagg
     8821 gtccccgcct cgtcccgcgt gagccggagg gcgggctgtg ccacgtgctt ttcccgtacg
     8881 gcgagtgcca cgtctgctcc ttgactcaca gagaactctt gatcttgagg gatgggggcg
     8941 gggacgtggg cgcgcgaggc gtggcggcct cgcgggccgg tccgcccgga gccactcctc
     9001 caggcgttgt caggatcctg tcccgtgtcc gcagccgccg ggcgaactcc tcgtcctcgg
     9061 acagcaggag gtggtggatc cgggacagcg agtggtgcgg gatgccgggc cacatgtggt
     9121 gaacggtgtg gtagccgtcc gcgtgcgggt ggaagagcca gcgctggaga cgcccggtgt
     9181 tcgacaccgt ggcgtcgaac accgtacggg cgtcggagta cacgtgctcg tcggcctccg
     9241 cgaccagtcg cagcggcggc agcagcagga agtgcgcgaa gagccagacc ccggccgcga
     9301 cggcgccggt gcgcaggtcc agcagaaggg cggtgggcgc ccccacgcac aggacgctcc
     9361 acagcagtgc cacgagcgga gccagggcgt tggtgcgcag ctcccgaagc cagcccagct
     9421 ggtagcgcag cagccgggtg cacacgccgg cgacgaagag cctcgccgag gtgcggggaa
     9481 gtgcctccat gtcgagctcg gcgtaacggt atctgtcggg atcctcggcc gtaccgaacc
     9541 ggccgtggtg aagcagatgg ctggtccggt acgcgctgat ccggctcccc gtgggggcgg
     9601 cggcgaggag atagcccagg acgtcgttca agcgccgccg gtgcctgctc cagttgtagt
     9661 gggaggcttc atggacgagg ttctccaggg cccgcagctg gcgggcgatg accaccccgg
     9721 cgagcagcgc cgggacgatc gaggcgagcg ggtggttgac gatgagccag gccgcgccgg
     9781 ccgccatcag gccgacgacc aggtgatcca gcagagcgca ggaagtggtg acccaaagac
     9841 gcgtcctgtg cgcgtccttg atgtccaggc gaagccgcga gggggcggtg taccccttcg
     9901 catagggcct gaccgtgagt tggtccttct ccgacacggg catcagcatc tctccgacaa
     9961 cgatgaacgg ttaccgagct ggtcgtgagc ggtgcacggt tcaggagccg ttcatcaggc
    10021 tgaggagttc ggtccgctcg aagctgttct cgcggaagac gccctggaag acggcggagg
    10081 tcatctgcgc ccccgtcttg ataccgcgca tcgtcatgca caggtgctct ccgcggccga
    10141 tgacggccac gtcgggcgac ttggtgatct cctcgatctc ggccgcgatg tcggcgacga
    10201 ggcgttcctg cacctggagc ttgtgagcgt gcttgtgggc gatccgggcg aacttcgaca
    10261 gcccgaggag gctgtcgtgg gcccggtagg ccacctggag gtcgcaattg aagggcagga
    10321 ggtggtgctc gcagagcgac cagacgcgca tgccggagac catgacggtc tggttgctgg
    10381 cgacactgct gaagacggtg tcgaggtttc cggcgtcgta gtcgacgaac tcgcgccacc
    10441 aacgcgcgta gcgccgaggg gtgtcgcgca ggccctcgcg gtccgggtcc tccccgatct
    10501 cgatcaggag gcgccgggct atggactcga gcgggtcgcc tccctgcacc tcgtcctgtt
    10561 ccaggatggt gatggcggaa gcgtccatgt cgatgctcat ttagattcct ctcttgtcgc
    10621 cccaggccag gacgtgcagg cgggtggaga gattccagcc acgccgcacg acctcgtccg
    10681 cgagggaact caagtgctga ctgatgtgtg ccacgctctt gccctcaggc atgatccaga
    10741 tcggggagat cccgaagtcc gcctgcagga cagctacttc gtccaggtcg tcggtggtgc
    10801 ggcagacgaa cttgaacgcc acgtcggggg tctgcgccag cttgctcagg gcagcgggca
    10861 cgatccgctt ggacgcgggg tccccggcgt gggcaagctt cggggagacg ttgaagcgca
    10921 ctccgggtgt gatgatctcg tcgtccgggg ccacggtccc gttcgtctcg aactccacgg
    10981 tgacgcccgc atcgagcagc ctcttcagca cggggcgcag ccggcgctgc tggctcaacg
    11041 gctcgccacc gctgatgacg acgaggtcgg tcccgagcgc gaggagctcg tcgaccactt
    11101 cgtcgacgtc cctgttgtgc agttccttgc gggggtcgaa cgcggtcttc tcgtcactcg
    11161 tccccttcca gtcccaggtg tacggggtgt cgcaccagtg gcaggacagg ttgcacccgc
    11221 ccagccgcag gaaggcgcac tgacggccgg ccgacgggcc ctcgccctgg accgtggggc
    11281 cgaagatctc attgacgacg atgctcacgg ccggtactcg gcccaggtct tgtcggtctc
    11341 cgagacgcgg acggcgctga gctcggggta gcgctccgtc cactggtcat agatccacat
    11401 ggccatgttc tcggcggacg ggttccggtc ctcgatgatg tcgttgaggt gccggtggtc
    11461 cagcgtgtgg tcgagccact tcttgaagtc ggccaggtcg ccgtagtccc gtacgaaacc
    11521 gggctcggtc agctggtccg gggccgcgga gagcttcagc tcgatgatgt agttgtgccc
    11581 gtgcagccgg gcgcactggt ggtccgaggg caggtgttcc agccgatgac tcgccgagaa
    11641 gtgaaattcc ttcgtgatgt gcagcatcaa cctactcctt gaagtaaacc gtggggtcag
    11701 tcgtctctgc gcgctcgaac gcctggatcc ggtcgacgca cgcggcgcat gttccgcagt
    11761 gcacctcagt gcccttgaag cagctccagg tctcggccca gtcgacaccc agcttttcgc
    11821 cgagccgaat gacgtcgtgc ttgtggagat cgatgaaggg ggccacgacc tccagatgcg
    11881 ccggcgcgta tccggcgcac gcaatcttct ccatcgcatt gaaagaggag atgaattcgg
    11941 ccgaacagtc gggtgcggtc gacgcatcgc ccgccagagc cccgatggca acctgatccg
    12001 ccttgacagc ggcggccttt ccataggcta cggacagcag aatcacattg cgattcggta
    12061 cgacgttaac acttccgggg gccgtgtagt gctgatccgg aacatcgacc tgggaatccg
    12121 tcagggagta tccgggaagc atggaagcga cgttcgacag atcgacgatc tcgtgctcgg
    12181 cgccgatacg gtcggccgcg atccgggcgt agtcgtgttc tttgcgatgc cgctgaccgt
    12241 agtcgatgga gagcagatgt acctcatgcc cttcggcatg aagatgatgg gcgagcacga
    12301 cggagtcgag cccgccggaa acaatcgcga tcacacgtgc cacggtgacg ccttcctgca
    12361 aacggaatgg gtggtggggc ccggacgcgg gcacactgcg gtgtccttcg catcagcggc
    12421 gtacggtctt ccgcgcacgc ctcggtgacg ggccgtcggg cagccgggaa agagaaaccc
    12481 ggaaagaagg ggaaggtgcg gtaagaattg agcagcggag tcggcgcccc tcgcatcgag
    12541 ggcagcccca cactccggaa aggcggccgg gcgacctaat ccaccggggt gccgaccagg
    12601 cggacgagtg gtgtcgcggc acgcagagca tcggcgcact cctgcggaga gacaccggtc
    12661 gtgaccacgt acgcataccg tccggccaca tgatcgcggg gcggcagccg aaggcggcgg
    12721 cccggctccg ccatgggcgt cacctcgtgg acccccgccg gcagctcctc ctcgaccgtc
    12781 agggaggtga cgtcgagatc gtgctcggga tacaggaact cgacgtgggc ggaggcggtg
    12841 cgcaccggcg ccacgtcggg ccggccgccc gcggcgaggt cggcggccac catgccgtag
    12901 tcgacgcccg tggccaggcg ggccgcgtac gggatgaggt cgccgccgag gcgggcgttg
    12961 acctccacca ggcgcgggcc ggtccgggtc agccgcagct cggtgtgggt caccagcgtg
    13021 tcgagtccga gcgcggtgtg cgcctcctgg aggacgcgcc gcacctccgg gtcgtgcagc
    13081 agcgggtcgt ccgcgctgac cgtgtggccg acctcctcga agtgcggggc gaagccgagg
    13141 gccttgcggg ccacgaacat cggggtcacg cggccgttgt ggcacacgct ctcgacactg
    13201 acctcggggc cgtccaggta ttcctcgacg agcacccacg cgcggtcgcg cgggatctcg
    13261 tcgaagtacg ccgccgccgc ctcggagtag gcggagtcca gggcctcggg cccgtccgcc
    13321 cgcacgaccc cgacgctggc cgcgagggca cgcggcttca gcacgacggg gtaaccgatc
    13381 gcccccgccg cctcccgcgc ctcttccagc gaagcgacgg cacgggagac gggctgcgcc
    13441 acaccggcgg ccgccagggc ctggcggccg aggtgcttgt cccggcaggc gagaacgcct
    13501 tcggcgttcg ccgtcggcag cttcagctcc tcggccatcc tggccgcgat cggcacccgg
    13561 atctcgtcgt agcagagaac gccggccatc tccacgctct cggtgagccg aacggcggcc
    13621 tcgatcgatt cgaatgcgtc gagcgtgtcg acgatcgtgt ttccccggag ataacgtgat
    13681 tcccaggtgg gctccttggg agcgaacagc cagagatcat agaagtcggc aaccgacttc
    13741 agaatgtatt cacgccacag ttgcccgccg ctccccacca gaagaagaca ctggcgagtt
    13801 gatcggtcat gtgacccggc ttccgccgca tccccttgtg gctcaccaac tcgtggcatt
    13861 gcaggaaccc cgttcaacgt tttcgcgata agccttgatc cgacttcgat ccagcgcaca
    13921 ccactgttac ctgatcgtct caccacgtct acagcgaacg aggatcgaaa acacgtcggc
    13981 agtaaaacga ggggggagaa atcggatatt agccagatag ccgatgaatc acgtgacacc
    14041 gccggcatca ctcttcgcca gctgttcatg caggagataa ccggcatgga gccggttacg
    14101 tgctcctatt tcctgcatga ggtcggcaat gtgccgctga caggtcctca gagagagccc
    14161 cacccgcgcc gcgatcttct tgtcgctctc ccccaccaca aggaggcgca tgatggtgtc
    14221 cttgacctcg gaggagacgt gtacgatctg gcccttgctg tagctcaggg ggaaggggcg
    14281 ggctccgacc caggtccgct cgaaggtgtc caccagcacg tcgatgacgt tctcgttgcg
    14341 caggacgagg gccccctcgg ggtgtccttt cagcgcaagg acggccaccc gccggtcgaa
    14401 gacgagcatg cgcgggaagc cgctggccgt ggtgcggacc tccccgccga gcggtgccac
    14461 atgttcgacg taggcggccg tgccttgatg gaactgcgcg gtgtgctggt acaacgtgcg
    14521 catgcggaca ccgcgttcca gcagctcctg ggcgaacgtc agggcggtct cgagctgctt
    14581 caccggccgg ccgccgcccg gctgggaggt gagcacctcc gtcgtggccc gtgcgctgaa
    14641 ctcctcgatg agggtcagca ccacgtccag gtcacggacc acctcgatct gtccggcggc
    14701 cgattccacc tcgtcccagt agaccggcag cagtgacccg aggtcggctc gaatccggtc
    14761 cgccttctcc tgcatgacgg agatctcgcg taccagcggc ccgaggaggc gcagttgggc
    14821 cgagtcgggc gccacggcgg cgaacaggtc gcctcccgcg tcctgttgga gcagtcgcag
    14881 ctccaccagg cccgcgatca cccggtcggc ctccgatgcg tccaggccga gttcctccgc
    14941 cacgacctcc gcggtcagcg cgcggcgtcg cacggccagg gcgtacgcgc gccgcatgtc
    15001 cgtggacaga tgcatatcca tatatcgacc aagcgcccct cgtggtgctt cgcgtccccc
    15061 cgcgcgccat gcgccacccc gtgtcatctg agcagaccta atctggtcag tggggggtcc
    15121 ggaccagcga ctatcgaact tcgcacgcgc gtgaggcctt gtcaaaggcg ctttttttcg
    15181 gccggtgttg gcctgaaatg attgaccctc cgagagatca atggtgtaag cgggccgata
    15241 acggagaacg cgggttatgt atcgccccct gtacggaaat ggcccggcat ccgacttata
    15301 ccgaggggaa ccagggggct gtcgccggtg aacgccgcgc cggtccacga cagtcaccag
    15361 agtcctcata tgcacccctt gtgccccttg tacccctagc gggttcccgc caacagagat
    15421 tcgacccggg tcggctctgg acatgtcgct gcgcgaccac aaagagtggt caccgaccat
    15481 gcgcacagaa cgcgggaacg cacgggggaa caaccgaaca tgagacttgt caccgaaatc
    15541 ctgaagagct ccctgctggc ggcgacgctg ctcggtctcg cagggccgac catcgacgcc
    15601 tccaaccggt cgacgcaggc cgatacgcgg gcgaattccg cctcgtgcgg ccacgcctgc
    15661 ccgaacaacg cgccgggggc agatctcggc tggggctgat ccgcgtcctc acctcaccct
    15721 tccccgcacc ccagcacacg ccgccgtgcg agcggaacgg cctttggtga tttcgtacgc
    15781 ccatgccgct cgtcctccgc accctgtgag gtgacgcctt gctccacacc cgtcgtcgtc
    15841 cggtcggttc cgtcctcctc ctcggcggaa cccgccccga accggtcaga gccgccaagg
    15901 cggccggact ctccatcacc tacctcggag ccgcggcgcg gacaccccgt gacatcctcg
    15961 acaacgccga cgggtgcctc ctgctggagg accccacacc ggagaacatg accgaggccg
    16021 cccggaagct gcacgccgag aagtcgttcg gtgtggtcgt caccatggtc gaccggtacc
    16081 tggaggccgc cgccctcctc aacgcggaat tcggccttcc ggccaatacc gtcgacaccg
    16141 tgcggtcgat gaacgacaag caccggatgc gcgcggcggc cctgcactcc gcctgcgccc
    16201 cggtggccca cgccgccgtc cgcaccgccg aggacctgcg gtccttcgcg ggccggcacg
    16261 gctacccctt catcctgaag ccggtggacg gctcggcgag ccgcggcgtc gccctcgtgt
    16321 ccgacgccgc cacgctcgag tccgcggccc gggccatgac cggttcggcc gcgccggagt
    16381 cccgctggat cgccgaagag ttcctctccg gacccgagtt cagcgtggag actttcagca
    16441 ccgacggcag ccaccacgtg gtggccgtca ccgagaagtt caagggcgac aacttcgtcg
    16501 agatcggcca tctggtcccg gcccgggtcc gcgcggcgga tcacgccgcc atggccgcgg
    16561 aggtcggtgc cctgctcgac gccgtcggcc tgaacgaggg cgtcgcccac accgaggtcg
    16621 tcctcacgga cgccggaccg agggttgtcg agacccacag ccgcccgggc ggggacggca
    16681 tcgtcgaact cgtacgcctg gccaagggtg tcgacctcca gcagatgacc ttcgactggt
    16741 tcgcgggcaa gcccgtcgac ccactcctgg caccagcggc gagagcctcg gccacctggt
    16801 ccctcacgcc gcccgagggc accgtcacgg ccgtctccgg tctcgacgag gcgctccgcc
    16861 acgaaggggt gacggagggg tacacggtcc tcgaaccggg tgacacggtc cgtccgctgc
    16921 gcagctccga cgaccgcagc ggggcggtca tcaccgtcgc ccccggcccc gacgccgcgc
    16981 tcgcgcgggc gcgggcggcc gtggatctca tcgatgtgac cgtcgtcccg gccggcgtcg
    17041 acctcggggg gccggttccg cgatgagcgg agaacgctcc tacggatacc gggtgctctt
    17101 ctccgagccg gggatcctcg tctacgccct cgcagccgcc ttcggcaagc tccaggcggg
    17161 catgttcgca ctgggcaccc tgtacgcggt cgccgaccag cgctcgtaca gcgccggcgc
    17221 gttcgtcgtg gccgtatcgg ccctcggcgg actgtccacc ccgctgcgag gccggctcct
    17281 cgaccgctac tcctacggcc cggtcctgtg gacgatcatg gccatccata cggtcctggt
    17341 gggggggctg ctggtcaacg agcacagggg agggccgttc tgggtcacgg tcgcctcggg
    17401 cctgctgggc aacctcgccg ctccccccat cggcgtcgtc acccgtgtga tgtggcggtc
    17461 ggtcaccacg gagaagagcc gtcccacagc cctggccttc gactcggtcc tggccgacgc
    17521 cggcttcatc ctcggcccgg ccctggccgc gctcgtctgc gccaccctcg ctccctgggc
    17581 cggtctggcg gccgtcctct tcttcaccgc ggtggccatg ctgctgctgc cgaagaacat
    17641 cggcgacgac aagacctcgg cccggcaggg cgaccgccat tgggccgggc cgctcaccag
    17701 cccgcggctg gtcctcctgc tcggcgcggc cctgtgcttc gccacgtccg tgagcgtgct
    17761 ggagatcgcc ctggcgacgc cccacggcga cggggactcg aaggtgctga gcggactgct
    17821 ggtgagtgtg ctggccaccg gcagcatcgt gggcggtctg ctgatcggcg cgatgacgcc
    17881 ggaactggcc aagcgggcga ctcgactgcc ggttctgctg atgtccctgg ccgtcttctc
    17941 caccgcgctc gccttcggca acaaggcggg ctggctggtc gccgtaccgc tctgcctgct
    18001 caccggcctc tccttcggcc cgtccttcgt cgccgtgtac ggccgctccg gtgacctcgc
    18061 gcccgcgggc atggccgccg agacccaggc gtgggccggc accgccctcc agctcggctc
    18121 cgccgccggt gccggcgccg gcggtgtgct gctggacatc tggggccctc cgggcgcact
    18181 ggccctcgcc ccgatagccg ccgtgatcgg cgcggcgagc gccttcgcgg gcgaccgcct
    18241 gcggacaccg gtggccgagc cccgggggga cgcgattccg gagagcctgt agtggggttc
    18301 acgctgaacc tccggccgga agggccggac atcggccggc ctgcccggcg ttgtcccggt
    18361 cggccgtgcg gccgaccggg acagcggtca cgtccgggat gccggcggcc cgctcttcac
    18421 cgcgaggcgt cccttgcccc tatgccgaca ccggggcgtg cacctcgatg cgggcggagg
    18481 ggctgaactt cgccagcgct tcggccagtt cggcggcggc cgtctccagt tcggccaccg
    18541 gcatgggggc caggccctcc aacaggaaga gaccggacgt cgtctcctcg gtgaggcggg
    18601 tgcgcggacc ctgacgccag ttccagcggc ggcaggtgac accggcgtcg tcgcaccaca
    18661 ccacctcgcc cgcgtcgggg tgttcgacgg tcctctcgcc accggtcacg gtgacgaagt
    18721 cctcgtctcc ctcggcgcgt accagtcgca tcccgccctc gatgaggtcg aggtcctcac
    18781 cacccacggg gatcaagtgg gcaacgctga tggcgttgta gaggtccacc agcaggttga
    18841 tccggggcag accggcgtcg gacagtgccc gcttggccag cgcttccgcc gagttgcggg
    18901 tgcgtgaggg cttggagccg aaggcggtgt acgtctcccg ccaggaggcc acgtgcgggt
    18961 cctcgtgggg agcacgtccg tccaggcgca cggcgaggcg gcgggcggcc tcgtcgagga
    19021 aggcggaact ctcctcggaa ctgggtccgt tgacaaggtc gtacgcctcg atcgcgacat
    19081 gcgtgaaggt cggcgcgagg gtgtaaacct cgtcggccac ggtcagctgg aacgtcatct
    19141 gtctcgcctc ggggggctgg aaggtcacag gggcgaccgg gcccaggacg actgtcacgg
    19201 cgccgagaac ggccgcgaat tcaccctaca ggaccggccg attcccctgt gggcctcctt
    19261 gaccccgagt gacgacggcg gtacgggagc cgaccgggca tgctccgggt acgttcgacg
    19321 cgttcctggc gcgaacccgg gagatgtcga cgcccggcat atcccgtccc ggtggcgggt
    19381 agtggcccca cgcgcctctc cctggagcgt ccatgctgcg gatccacttc accccgagga
    19441 cctgacgcgg gtcagggtgg ccccgggtcc ggacttcctg tgggagatca ccaacagcgt
    19501 gcagaccctg caacggaccg acggggagcg ggtgttcggc acctggcggc gctgggtgcg
    19561 gccgcggctc ccggagagcc gccggctgct ctccccgctt ctgccgcccc gcgggtactc
    19621 cccgacttcc tcacccccac ctcgggtgac cgcaccacgc tccgggcagc cgtcgacacc
    19681 ctgctcggta cgccgcggcc gagactgcgg gcggagctga gccggctggc cgggacgaga
    19741 cggctgcccg gctgggccgc cgccctggcc gaaggcgacc cggacgcgct cgccaggctg
    19801 ggcaaggcgc tccacgccta tcaggcagag gtgctcgtac cccactggcg gcacgtccgc
    19861 gcggcactgg aggcggaccg ggctctgcgg acacggcatc tgatggacgg cggcaccgag
    19921 gcgctgctgg ccggtctcgg gcccgacgtc cggtggcggc cgcccgtgct ggaggtcacc
    19981 tacccggtcg agcagcatct gcggctgaac gggcggggcc tggtgctcca gccgtcgttc
    20041 ttctgctggc ccaccccgac caccctggcg gacggtgacc taccgcccgt tctggtacac
    20101 cccatccgcc actcggccga ctgggcggag ggcgcggcgg ccccggaacg ggcagcgggc
    20161 ccgaaccctc tcggccgtct gctcgggcag acccgcgccg acctgctgcg ggccacccgc
    20221 gccgggtgct cgaccatgga ggcggcccgg atgctccagg tgacccaccc ggccgtcagc
    20281 cagcacatga acgtcctgcg tgcggcgggc ctgaccacca ctgtccgcac gaccggtcgc
    20341 gcctttcacg tggcgactgc cgaggggcgt gcgttgctgg ccgccgagga ccgccgggcg
    20401 gggaccgggt agagcggcga actctcgtac gtaagccagg acttacagcg cttgtgcccg
    20461 tcaccgccgg gcccccacgc tgtcttctgt caccgccccg gccggacggc cccaccccgc
    20521 cccgccgcga cgttcccgta cggcaccgcc cccacaggag ccctcatgcg cgcgagactt
    20581 gtccccggca cgatcgcagc actcgcgatc ggagcacttc ttctccccgg caccgccgag
    20641 gcctcccccg cccccgccgt cccggtcgtg gacgtacggg cccacgactc gacgtccggc
    20701 acggccctcg cctccggata cggcaagccg ggaaccaggc tgcgcgtcga cgccggacgg
    20761 tcgagcaacg cccgctggct ggagatcgac taccaggtcc agcagaccgg ttactggtgc
    20821 ggtcccgccg cgacccgcat cgcgctctcc gcccgcaccg ccgcaccgag ccagggcgag
    20881 ctggcggcgc agctcggcac gaccgaggcg ggcaccgatc acatcggcca gatcaccgcg
    20941 gtgctcaacg cccgtctggg cagcggttgg tacgagacga aggagatgcc gaacgacccg
    21001 cccacccagg cacagcggga cctcctgtgg cacgacatcg tcttcgacat cgaccgcaac
    21061 tatccgctgg tcgccaacat cgtggcccct ccgggcaacc agccgcccgg ctacccgccg
    21121 gaccagacga tctaccacta cttcaccgtc ttcggctacg acgcggtcga ccgcacggtc
    21181 ctcatcgccg accccgcgtc cttcggcggc aaccagatct actggatctc cttcgatcaa
    21241 ctcgccaccc tgatcccgcc gaagggctac tccgcctgac gcgccgcgca ccgccctcac
    21301 tcccaccccc tgaccaggag gacacgttga gcacccaacg gcccacccgc agaggcgtcc
    21361 tgaaggccgc cgccggaatc tccgcgacca ccgcgctcgg cgcgggaggc gtcctggcgt
    21421 cggcgtcggc cgcccacgcg gtgggcgacg gcttcggtct gcgcatcgtg gaccgcgacg
    21481 aacgcgatcc ccgtatgcgc tacttccgct tcgcgaccga cgcgatcggc tggaaccccg
    21541 gcgtcaacgt cctgctgccg gacggctacc actccggcgg gcgcaggtat ccggtgctgt
    21601 atctgttcca cgggggcgga accggacagg acttcatcac cttcgaccgg atgggaatcc
    21661 gcgcctggac cgccgggaag ccgctcatcg tggtgatgcc ggacggcggg gccgcgggct
    21721 ggtactccaa cccggtcgtc tccaacgtcg gcccccgcaa ctgggagacc ttccacatcg
    21781 gccaactgct cccgtgggtg gacgccaact tccgtacgta cgcggagtac gacggccggg
    21841 cggtctccgg cttctcgatg ggcgggttcg gcgccctgaa gtacgcggcc aagtactacg
    21901 ggcacttcgc ctcggccagc tctcactccg gcccggccag cctgcgccgc gacgccggtc
    21961 tcgtcaccca ctgggccaac ctctcctcgg ccgcggtgga gttgggcggc ggtacggtct
    22021 acggcgcgcc cctgtgggac gaggcgcggg tcagtgcgga caatccggtg cagcgcgtcg
    22081 ggagttaccg gaacaagcgg gtgttcctgg tggcgggcac cagccccgac ccggtcaact
    22141 ggttcgacac cgtcaacgag acccaggtcc tggccgggca gcgggagttc cggggcacgc
    22201 tgggcgcggc ggggattccg cacgagtttc acgaggtgcc cggcggccac ttcgtccggc
    22261 ccgatctgtt ccggcgggac ctggacggga tcgtcgcccg cctccgtaag gcctgacggg
    22321 ccggggccac ctgcgtacgg cgc
//
