LOCUS       NZ_CP025018            23790 bp    DNA     linear   CON 12-FEB-2024
DEFINITION  Streptomyces sp. M56 chromosome.
ACCESSION   NZ_CP025018
VERSION     NZ_CP025018.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. M56
  ORGANISM  Streptomyces sp. M56
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11742376)
  AUTHORS   Kim,K.K.Hyun., Klassen,J.L., Ruzzini,A.A.C., Beemelmanns,C.C. and
            Clardy,J.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-NOV-2017) Leibniz Institute for Natural Product
            Research and Infection Biology - Hans Knoll Institute,
            Adolf-Reichwein-Strasse 23, Jena 07745, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-AUG-2014
            Assembly Method                   :: HGAP v. AUG-2014
            Assembly Name                     :: M56v2
            Expected Final Version            :: yes
            Genome Coverage                   :: 94.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/12/2024 06:37:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,558
            CDSs (total)                      :: 9,473
            Genes (coding)                    :: 9,167
            CDSs (with protein)               :: 9,167
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 306
            CDSs (without protein)            :: 306
            Pseudo Genes (ambiguous residues) :: 0 of 306
            Pseudo Genes (frameshifted)       :: 86 of 306
            Pseudo Genes (incomplete)         :: 261 of 306
            Pseudo Genes (internal stop)      :: 28 of 306
            Pseudo Genes (multiple problems)  :: 61 of 306
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:58:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 10366146
            Orig. end                         :: 10389936
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP025018.1.
            Annotated using prokka 1.11 from http://www.vicbioinformatics.com.
            Bacteria and source DNA available from Christine Beemelmanns.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23790
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="46"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23790
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23790
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:13790](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13790
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            608..1888
                     /locus_tag="CFP59_RS42315"
                     /old_locus_tag="CFP59_08339"
     CDS             608..1888
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058167.1"
                     /locus_tag="CFP59_RS42315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08339"
                     /product="sensor histidine kinase"
                     /protein_id="WP_100809539.1"
                     /transl_table=11
                     /translation="MLWSATWSAWSGRSGSDGPDDPDERWLTAVLHIAFFLLLGSSLVR
                     YLIRDTGGAPNGWVIALFVAFGALYPPGRWPAPAPGPGGRPSGRYLVWLTAVLAAWVAL
                     LVLAPSAAWCAMPLFFTGLHTLPTRFAVPLAAVLTALVVASKLRFMHDGFDPNALIAPP
                     AIAAVAAAVLIHLRRQSARQRTLIDDLVRTRRDLAATERRAGILAERQRLSSEIHDTLA
                     QGLSSQRMLLQAADRTWETDPQAARGHMRDAAEIVSRSLAEARRFVQDLAPADLAERSL
                     AQALGALAERESGPGRTVDFRLDGPLGPLPERVAAALLRIAQGALANVREHAGAGRAAL
                     TLTWMGDQICLDIADDGRGFDTGAVPAPGADRSRGHGLPAMRARVRQLGGTLTVESAPG
                     EGTVVSAAIPVEPLSALVPDRPVEVTP"
     gene            2008..2628
                     /locus_tag="CFP59_RS42320"
                     /old_locus_tag="CFP59_08340"
     CDS             2008..2628
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125951.1"
                     /locus_tag="CFP59_RS42320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08340"
                     /product="response regulator transcription factor"
                     /protein_id="WP_079153682.1"
                     /transl_table=11
                     /translation="MRLLLCDDHAVVRAGLRALLASTEGIEVVGEAGSGEEALAMATRL
                     RPDVVLMDLQLGEGMDGVTATRRLVRGDPPAPRVLVLTMFDTDADITRAIEAGATGYLL
                     KAERPEELFAAIRNAASGRTALSAPVADRVLARMRSPRPGLSERERDILRQLARGLGNR
                     EIARALFISEATVKTHLGRIYGKLGVETRAGAVAVATERRLLP"
     gene            complement(2634..3695)
                     /locus_tag="CFP59_RS42325"
                     /old_locus_tag="CFP59_08341"
     CDS             complement(2634..3695)
                     /GO_function="GO:0008381 - mechanosensitive monoatomic ion
                     channel activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058165.1"
                     /locus_tag="CFP59_RS42325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08341"
                     /product="mechanosensitive ion channel family protein"
                     /protein_id="WP_100808329.1"
                     /transl_table=11
                     /translation="MNRALTLHDVIVVGAALVCGAAGGVLLRLALRWLGERARATRWSG
                     DDIIVDTLRTLAPWASMAAGVAAAAAALPLTPAVGHDVDQTLVAALILVTTATAARVVA
                     DLVRSLALSRSGVAGTATIFVNITRIAVLAMGVLILLETLGVSIAPLLTALGVGGLAVA
                     LALQDTLANLFAGVHILASKTVQPGHYIRLSSGEEGYVVDINWRNTAVRQLSDNLVIIP
                     NAKLGNTIMTNFHQPEQQMSVMVQAKVGYGSDLDHVERVTVEVAGKVMSGVEGGVVDHE
                     ASVRFHTFGESGIDFSVFLRALEFSDQYLIKHEFMKELHRRFRAEGIEIPLPTRTLVLP
                     DQDRVPLPGRPAI"
     misc_feature    3972..3988
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 19.93"
                     /tool="antismash"
     gene            3987..5186
                     /locus_tag="CFP59_RS42330"
                     /old_locus_tag="CFP59_08342"
     CDS             3987..5186
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058164.1"
                     /locus_tag="CFP59_RS42330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08342"
                     /product="MFS transporter"
                     /protein_id="WP_069872208.1"
                     /transl_table=11
                     /translation="MESRRNDVSRAWPYLAAAYAFVVTMCGTTLPTPLYSLYQREFGFS
                     SFMVTVIFAVYAAGVIVALLLLGSVSDFIGRRPVMLAALVLSALSAVCFLLARGLPELF
                     AGRTLSGLSAGLATGTATVTVIELAPPSRRRAATLLATGANLGGLGVGPLLAGVLAQYA
                     PAPLKLVFVVDLVLVAVAAAVVLALPETVRTRSRPPLRPQRLRVPKEMRSTFAAAAMAG
                     FAGFATLGLFTSVSPTFLSEVEGESNLAVAGAVAFSVFAASIAGQVLGRRLGPGWSLPG
                     GCAVLVAGMAAIAVSLAIASLALLVLGAVVAGTGQGLSFHAAVRVVTERSPADRRAEVT
                     SALFVLMYLAISIPVIGVGALTVAVGLRTAGLVFTGCVALLAVATLLRVRALSAETADR
                     "
     misc_feature    complement(3997..4012)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.19"
                     /tool="antismash"
     gene            complement(5255..6166)
                     /locus_tag="CFP59_RS42335"
                     /old_locus_tag="CFP59_08343"
     CDS             complement(5255..6166)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835145.1"
                     /locus_tag="CFP59_RS42335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08343"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_069872210.1"
                     /transl_table=11
                     /translation="MPAPVFSRRRGMRVAAAAAVALPLAAQPQYVATAVPAAPVAPADG
                     PRLAAMTFNLRYASDSEPNSWGRRRPVMRELLRRARPHLLGTQEGLYGQLRDIAQDLGQ
                     RYSWIGVGRMGGSRDEFMAVFYDTGRLEPLEYDHFWLSDTPNVIGSNTWGGAVVRMVTW
                     VRFHDRHTGKEFYALNTHLDHRGQNAREHAAALITERLGGLDSALPRIVTGDFNVAAHG
                     NPVYDAMLNGGTLVDTWDTAERRGPLYGTFHGFGPLTPDGDRIDWILTSPGVRTRHAAI
                     DTFSQDTQYPSDHLPVRTVLEL"
     gene            6426..7433
                     /locus_tag="CFP59_RS42340"
                     /old_locus_tag="CFP59_08344"
     CDS             6426..7433
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (extras)
                     Sulfotransfer_3: Sulfotransferase domain"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060770.1"
                     /locus_tag="CFP59_RS42340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08344"
                     /product="sulfotransferase"
                     /protein_id="WP_100808330.1"
                     /transl_table=11
                     /translation="MSVRPLTFVVGTGRCGSTALSRVLRLHPDLLSVSELIASLEPDAL
                     PEAPLTGAEFWRILATPRSFANRVIRDGIPLPEYRYPHVEGRFSVSGGGIPAVCMMTLP
                     HLTDDPDALFDALEPELSRRPAAPVADHYRALFGLLGERFGRRAVVERSGYSLRSVPRL
                     REVFPEARFIHLHRDGADCALSMSRHPGFRLIQLMTERAETTEDLPAGLDALLSDDDAD
                     LRPLYQRSVPTAEFGRLWSATIVEGLERLSRLPADIRMSLSYEGLLDAPERELTRLAHH
                     VGVEPLPEWLAAGRALLDGDRRGTAAATLPPAELAALRESCAPGARALSAVHGG"
     gene            complement(7765..8688)
                     /locus_tag="CFP59_RS42345"
                     /old_locus_tag="CFP59_08345"
     CDS             complement(7765..8688)
                     /GO_function="GO:0001216 - DNA-binding transcription
                     activator activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="CFP59_RS42345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08345"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_159398995.1"
                     /transl_table=11
                     /translation="MIDLRQLTVLTEVCRAGSYSAAADSLGYTQPAISYHMRALERAVG
                     MALTVKAGRGVRLTPAGHRLAERAQGVLAGLRDVENEFEALAARTRGRVRMSSVQSVSV
                     AVLPAALARLGASRIEVEVELGQTASQDAYRLLDSGETDLAIVADDEPGEATGEATGPA
                     VTPLRRVPLLVDRRHVLLPRGHALAGRRSVRLADLSRERWILERDRERLLRRCAEAGFE
                     PRVVTTTDDQATTLGLVGDGVGIALMDGLGLLPRCDPRVEPRPLDDWPRRHVCALLRPE
                     AARVPAVAALLEALRAVAVEQSRDAA"
     misc_feature    complement(8694..8709)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.69"
                     /tool="antismash"
     misc_feature    complement(8701..8716)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    complement(8832..8847)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.77"
                     /tool="antismash"
     gene            8985..10004
                     /locus_tag="CFP59_RS42350"
                     /old_locus_tag="CFP59_08346"
     CDS             8985..10004
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (19-319). E-value:
                     1.1e-43. Score: 141.7. Matches aSDomain:
                     nrpspksdomains_CFP59_RS42350_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058160.1"
                     /locus_tag="CFP59_RS42350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08346"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_231981596.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.8e-41, bitscore:
                     141.6, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPVVAENNPFHQMSLNETVHPPLPEVVDAVLRTARNAHRTLDAL
                     GTGLCQALAAHLGVGPEHILAGPGSGALLQQLFSTLTGPDTDTVHAWPSWEAYPMMAAN
                     AGSTTVRVPLSGYDHDLKAMADAVTDRTRMVLLCTPNNPTGTALDQERILRLLDRLPAH
                     VTVVIDEAYRDFADPGAIADGIALHRADERVCVVRTFSKSYGLLSLRVGYLVAHEPVLA
                     PLRSVLPFHRVSAVAQEAAIAALGAHERVLGQCARTVEERERLHRTLLDQGWEVPASQG
                     NFLWLPMTSGVERFTQFCADHGVVVCGKPGEGIRVTVAEPAANQAFAQLAGKYREATV"
     aSDomain        9042..9941
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CFP59_RS42350_Aminotran_1_2.1"
                     /evalue="1.10E-43"
                     /label="CFP59_RS42350_Aminotran_1_2.1"
                     /locus_tag="CFP59_RS42350"
                     /protein_end="319"
                     /protein_start="19"
                     /score="141.7"
                     /tool="antismash"
                     /translation="VHPPLPEVVDAVLRTARNAHRTLDALGTGLCQALAAHLGVGPEHI
                     LAGPGSGALLQQLFSTLTGPDTDTVHAWPSWEAYPMMAANAGSTTVRVPLSGYDHDLKA
                     MADAVTDRTRMVLLCTPNNPTGTALDQERILRLLDRLPAHVTVVIDEAYRDFADPGAIA
                     DGIALHRADERVCVVRTFSKSYGLLSLRVGYLVAHEPVLAPLRSVLPFHRVSAVAQEAA
                     IAALGAHERVLGQCARTVEERERLHRTLLDQGWEVPASQGNFLWLPMTSGVERFTQFCA
                     DHGVVVCGKPGEGIRVTVA"
     gene            10001..11029
                     /locus_tag="CFP59_RS42355"
                     /old_locus_tag="CFP59_08347"
     CDS             10001..11029
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058159.1"
                     /locus_tag="CFP59_RS42355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08347"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_100808333.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.1e-50, bitscore:
                     170.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPPDVAVTEVADPLAEAAPTMELLLRELDRRWPREAERLHRISR
                     YALLPAGKLLRPLLLMEAAEAVGGGGPAVVPAALSVEYLHVGSLVHDDVIDGDAMRRGR
                     PSVAARHGTADAIVTGDALMLGTFGVLTDGTDEAGGLPPGRVLDAVRVFAQAGVDLCRG
                     QAMEAELRGDLGCGLDRYVTMTALKTGALFRAACRGGAILGGGSPAQRHALTAYAEHLG
                     SAFQMHDDLLPYTSDSRTTGKSALSDIAAARPTFPVLLCHAMAGAPACARLEAALGGAL
                     PAADALRTVHELLETTGALDAARDRATAQADLAKSCLAELPRSRATAVLAAVADLSVSR
                     DR"
     gene            11034..12032
                     /locus_tag="CFP59_RS42360"
                     /old_locus_tag="CFP59_08348"
     CDS             11034..12032
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ubiA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058158.1"
                     /locus_tag="CFP59_RS42360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08348"
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_079256240.1"
                     /sec_met_domain="ubiA (E-value: 2.7e-19, bitscore: 68.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAPRTALLAHLQTWRPYTLWYPGLVGLAGASLTGSHPTTGQLTV
                     AWAAPTLGWVAGHYLGDYYDRDLDALSKPQRPIPSGRLSPRTAVAAGIGCALAVAALAL
                     WANWRAVAVAAAAMAGIVAYSRVLKGRGLPGNLVRGVLTALTVLFGAMAVQPWPPWRTL
                     PFALVFLAHDTASNLVGTLRDVDGDREGGYATVPVRRGVRRATHTAAALYLTAVAVACA
                     ATGLVPEDTAGYLVLLSAAALCGAGVFGLLLRSPGHLTPALALRAHAVLVCERLVLAAA
                     VVAAGAGAVPALALLTPLLAVSVITQSRMRSRHEFPAPLADGRPTLPDPRP"
     gene            12066..13790
                     /locus_tag="CFP59_RS42365"
                     /old_locus_tag="CFP59_08349"
     CDS             12066..13790
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058157.1"
                     /locus_tag="CFP59_RS42365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08349"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_100808334.1"
                     /sec_met_domain="T2TS (E-value: 5.4e-37, bitscore: 126.6,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPSALTESVGTAIVAGAEALLAHRRDDGAFVFGAHHASPLNTAG
                     ALTALHFADPEGSAETIERGVTWLCETQRDDGGWAMRSVPTEPLTTALAAAALQLVAPR
                     RAASAVRAARDRFEELGGSAAVPEPVMTALIRQFHTFAGLPHEGAQRRLPLELLLLPGL
                     SRRLLSLRLPIYAGQALAQSAHRRRGPVGRALDRLARPRALAILRDAYEREGATGGFST
                     DPWLTGLICLGLARSGQAPDLVRAAAGWLRSAARPDGSWDLMPLDVTWTNFATAALIEA
                     GRADDPQLIGTREMLHRHQQPESFDALGCPAGYWGFSSPRSWPMALETAESSAILLRLP
                     GGAYDPHVRAGLAWLTATQDAAGSWSLAVRNTKPGGFGPCPQMTAKIVGALLDSGAGAD
                     DPRVAKAVRWLVGRQRPDGSFDAMWYRGGTPGTAAALEALTRAGHTEEHRRAAARARDW
                     LLRTRHPDGSWSTGEGTRPGTVEETAWALRGLLAARSSPADPALAAAARWLVDAQRADG
                     GWNPAPVNEYIRGCARYADDGIAAGLALRALAHYRSATATTTTRTKDITGDGEGGRP"
     gene            13787..15091
                     /locus_tag="CFP59_RS42370"
                     /old_locus_tag="CFP59_08350"
     CDS             13787..15091
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058156.1"
                     /locus_tag="CFP59_RS42370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08350"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_100808335.1"
                     /transl_table=11
                     /translation="MSPDVLVCGAGVGGLAAARALGGLGLDVLVVDKQPRIRPIAKGEV
                     LQPGALRLLRSWGVEQRLDAQGAVRLGRLVVRDPRGTALMSLDYGQLPAPDQWLLAHDH
                     TTILTALAEGLGPRVELRRGVRAELPLRDDSGRITGLRLAEGGRVYEERAPLVVAADGI
                     SSRLRSWADIEAKRIDYPHRLVSFDIADAEAAARADDFSAYVTDRGLRLLYPLPGGRLR
                     LYLQAGPDELRGVTARGGLADWATRALSQVPALEPLATSLLAHLDTRQTLPVGRLLSPR
                     LAGHGLALVGEAAYAVHPMAAQGMNTAITSAGALAERLADRLERMGGMSAAAVDGALCD
                     YHERQLPLLAQAARTSGNAARMVTDLSWRGRILGRRAVRHTGANPRLLHTVTHNMSGLG
                     PRPLTPLDRLQQLGLVPDPRAHRVPAAPAGRPQSM"
     gene            15106..15969
                     /locus_tag="CFP59_RS42375"
                     /old_locus_tag="CFP59_08351"
     CDS             15106..15969
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (7-250). E-value: 9.9e-61. Score:
                     197.8. Matches aSDomain:
                     nrpspksdomains_CFP59_RS42375_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121: dioxygenase, TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058155.1"
                     /locus_tag="CFP59_RS42375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08351"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_100808336.1"
                     /sec_met_domain="TauD (E-value: 1.6e-58, bitscore: 197.8,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTPELAVTPVSGALGAEIRGVDLTELTDELFERIYELLLEHLVV
                     FFPDQEHLTPKAHIALGRRLGELEVHPFLPKADGHPEIVVLDADQGAKADEWHIDVTFQ
                     PNPPVASILHLQVCPASGGDTMWSNQYLVYETLSEPMRELLDGLTAVHVLNTPQTGEHS
                     AEHPVVRIHPETGRRSLYVTRMWTSHIPQLSRPESDALLQYLFEHSESPRFNCRYRWQP
                     GAVAMWDNRATQHLAVNDYTGPRRGQRVTVLGDHPTGDTPRWKEYRPAPDERYYPRHVT
                     ARHGYR"
     aSDomain        15127..15855
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CFP59_RS42375_TauD.1"
                     /evalue="9.90E-61"
                     /label="CFP59_RS42375_TauD.1"
                     /locus_tag="CFP59_RS42375"
                     /protein_end="250"
                     /protein_start="7"
                     /score="197.8"
                     /tool="antismash"
                     /translation="VTPVSGALGAEIRGVDLTELTDELFERIYELLLEHLVVFFPDQEH
                     LTPKAHIALGRRLGELEVHPFLPKADGHPEIVVLDADQGAKADEWHIDVTFQPNPPVAS
                     ILHLQVCPASGGDTMWSNQYLVYETLSEPMRELLDGLTAVHVLNTPQTGEHSAEHPVVR
                     IHPETGRRSLYVTRMWTSHIPQLSRPESDALLQYLFEHSESPRFNCRYRWQPGAVAMWD
                     NRATQHLAVNDYTGPRRGQRV"
     gene            complement(15977..16861)
                     /locus_tag="CFP59_RS42380"
                     /old_locus_tag="CFP59_08352"
     CDS             complement(15977..16861)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058154.1"
                     /locus_tag="CFP59_RS42380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08352"
                     /product="lytic polysaccharide monooxygenase"
                     /protein_id="WP_100808337.1"
                     /transl_table=11
                     /translation="MTSHRTAAVGALLGALPCLFTALAAQPAQAHGAPTDPVSRTFACS
                     PEGGAAARSAACRAARAANGPEAADWDNLRIAGVEGGDRERVPDGKLCSGGLEAYRGLD
                     LARADWPSTRLSAGAKLTLTYRSTIPHTGTFELYLTKEGYAPTRPLRWSDLEPKPFATA
                     KDPALVDDAYRIQATLPAGRAGRQLLYTIWRNTSTPDTYYSCSDVVLSAAAGKGPKDSP
                     ERRATPSDGAAAPSVEVTAPPSRGDAPPSPATSAAEADDGGTTTPVLLAGGASVLVLGA
                     GVAATVRRRRPGR"
     gene            17057..17506
                     /locus_tag="CFP59_RS42385"
                     /old_locus_tag="CFP59_08353"
     CDS             17057..17506
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058153.1"
                     /locus_tag="CFP59_RS42385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08353"
                     /product="spore-associated protein A"
                     /protein_id="WP_069872232.1"
                     /transl_table=11
                     /translation="MNLSRRMAATAVLATAAIAGTVAITPQASAAATATYNGVCGTGYK
                     VVNSAPIGSKGTVFLTYNSAKGKNCVVTVRNATGKPVPMFAYLYVQGADESAEDGGAYT
                     SYAGPVYGDGRGKCVDWAGGIENQSTWTYGSNCGSLTAHRVTKGW"
     gene            complement(17612..18055)
                     /locus_tag="CFP59_RS49230"
                     /old_locus_tag="CFP59_08354"
     CDS             complement(17612..18055)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024966.4"
                     /locus_tag="CFP59_RS49230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08354"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_159398996.1"
                     /transl_table=11
                     /translation="MLDRLAVHELIHRWWFVFDEGQFDVWPELLTEDVHITSRSDTGKS
                     PYEEFIASDNQGREQVIAWQRKHREAAGYPLRHNASNIHIERVDGDDISVVSYMYATNI
                     TEGQVTPIAGGVVRCVVRSDGAAYRLAQLHIVLDTRAVAFTER"
     gene            18312..19661
                     /locus_tag="CFP59_RS42395"
                     /old_locus_tag="CFP59_08355"
     CDS             18312..19661
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058151.1"
                     /locus_tag="CFP59_RS42395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08355"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_173963361.1"
                     /transl_table=11
                     /translation="MHPVTGSRASAPAMGRPAPRRSADRGRTPPRMPAARPPIRSRADA
                     ETVALLHRTARVLIEEVPRLTDRIVTLMKEREPVYRSPSLDPHEVWREVHDSLSHNVRS
                     LVRPKETRESARSCAWRIGTDRAAQGFPLDALLHAYRIGCTVVWERLLETASKEDPLGA
                     QALVHVAADVWNFVDEHCTLVATAYQEVERQLSWHRENRYRIIVAALLDGTARVTDFPE
                     AEEVLGLPERGRYAVVALEGTDAPARAPHPVTGLCAGLRTVWHTAEGIAHAIVLLGDTD
                     GDGGDGYGGDGDGVGVERLVRGLELPPGVRAGVSPAVTGLAAVNTARRLADTALRTRPA
                     AGEAALLEERYPEALVVSSPELGTALADRMLGPVLALEPADRELLLTTLAAWLEADGSA
                     RRAGELLFCHRNTVLNRLRRYEQLTGRSLDRPREVMELSLALSAHRLLTS"
     misc_feature    18353..18367
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.37"
                     /tool="antismash"
     misc_feature    complement(19707..19723)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 23.13"
                     /tool="antismash"
     gene            19830..20228
                     /locus_tag="CFP59_RS42400"
                     /old_locus_tag="CFP59_08356"
     CDS             19830..20228
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CFP59_RS42400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CFP59_08356"
                     /product="hypothetical protein"
                     /protein_id="WP_100808340.1"
                     /transl_table=11
                     /translation="MSDHDHLWGSPVPSVPPVGSSATHPTAHRGPYRTTRRAATMPHHA
                     TAPPPPPPERRSPWQRPWPWPARAACAALTCHVAAVVVNCAAEGVVNLGAGGGFTVGAM
                     LIGLDTAVLLTVLARAHRRSGAAGEGER"
     gene            20225..21814
                     /locus_tag="CFP59_RS42405"
                     /old_locus_tag="CFP59_08357"
     CDS             20225..21814
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058149.1"
                     /locus_tag="CFP59_RS42405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08357"
                     /product="cation acetate symporter"
                     /protein_id="WP_100808341.1"
                     /transl_table=11
                     /translation="MSFLDPRTLAFVLFAGFMAISFLLCILAATGNDDPTEFYLGTGAL
                     SPMQNGLAIAGDYISAATVLSTTGTIALAGFDGVLIATSTVLSILLFMLVLAGPLCGRG
                     QFTLGDVLSERLSERPARVGTAVVVLVVVLPLLLVQLNGAGDMLALLLGIPGSGAVTGC
                     TVFIGSLMVCYAALGGMKGTGFIQILKTVLLLAAFVLLACLVLRRFSWNPVTLFDAAAD
                     ASGYGNGFWQSGRQYGDSLSGRLDVISVQLTLAVGAACMPHLTMRLHPIRGMRAARAAT
                     TWAVGAVTTILGLIVIVGAGATAVVGARALRASDPTGGDSLLLLTLALDPAAPEAHRSL
                     LFSVVACAVVATTLAAVAGLTLAAAASLAHDVLAKVVFRGRLSADRELAAARAAIVAVG
                     VTAVVLAIVTQHWNRQVLISFTFAAAASALLPVVLYGTLWRGFTVNGLRWALYGGLALT
                     AVAMAFSPAISGNPLAVFPDRDFHWFPLRNPGLITVPAGFLLGWFGSRIGCRARHAQDP
                     ARGDMPYATHPG"
     gene            complement(21837..22412)
                     /locus_tag="CFP59_RS42410"
                     /old_locus_tag="CFP59_08358"
     CDS             complement(21837..22412)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018384910.1"
                     /locus_tag="CFP59_RS42410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08358"
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="WP_186000339.1"
                     /transl_table=11
                     /translation="MSPPLNDDRSTRHSVRATARRTAALVNALTAEPDPDPGAIAGILL
                     DHGELGPLELTADDVAGLRTAALRLREVFTADGVDEAAGVLNRLLREGTGPLRLSSHDG
                     RSPWHPHLDSDDEAPWGEWFLASSCMALTVLLWEGQRPPGGLCSSPGCGDVFLTVGSGP
                     ERRYCSRRCATRERVAAHRRARAGSRSP"
     gene            22469..23677
                     /locus_tag="CFP59_RS42415"
                     /old_locus_tag="CFP59_08359"
     CDS             22469..23677
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058147.1"
                     /locus_tag="CFP59_RS42415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_08359"
                     /product="MFS transporter"
                     /protein_id="WP_231981597.1"
                     /transl_table=11
                     /translation="MLGRYAMRCYLGGAAAARTGDEMSGPALLLAGPALTGSATSGSSL
                     LAGVMVAAALGGPLFGVLLDRSPRPGRLLAAALALYAAALTAILLALERLPFALTVLLA
                     VGAGLLGPALSGGWTSQLPRVAPPGTLPRANALDAMTFSLAALVGPALAGAVAGALGAP
                     AAVAVSIALIGLALPAAWALPAPERPVSTPPPTSSVRADLTAGLRVVARNRRLARATAT
                     SVISCVGQGALLTCCPPLGAAVLGGADRGALLLSATAASALVANAALARHPRPPRPDTV
                     LLGGALLLALAPLLAAIGHPAPVIAAALLTGAAEGPLLTALFAVRHREAPERLRGQVFT
                     TGASLKITGFALGAALAGPLAAWSLPGALVAAAGCAGLAALVFVCWSNGTEATAPLPPP
                     GAV"
ORIGIN
        1 gctccggccg cagaccgtgg ccgaggagat agtcgaactg catctcgccc agcgccagcc
       61 accggtcatg gctgcggctg ccgaccgccg cttccgggct ggtgcgggtg tcggaccgca
      121 tcacggcgcg gtagtacgcg acatggtccg ggtagcggta gcgcagccag gcgtcccggg
      181 tggcgcggac cagatggcgc gggacgcgct gcggatgacg cagcgcgtag gagacgcggt
      241 ggccgagggc ggagcgattg acgctgaggt tcttggcggg catggggact ctctcgggct
      301 cgaggtgcgg acgcggcggc ttatgcgttc ccgcgtcgct ctggtcggta ccagcctctg
      361 cgccgtggcg gcggcgggga tcggtggagc ggccccggtc cgcgggcgat ccgggtgatc
      421 gtcgtatcaa ccgatcggat gatgcggcgt ccggccgggc gcgttaggac tggctggggg
      481 agcgaatcga agagcagtga agagaaccga ggatccgggg tgaaccgggg agtgaggagg
      541 ggccggggtg cggtcggcgg gcagggcggt cggggcaggc gggcggtccg ggcgggcgcc
      601 gtggtcggtg ctgtggtcgg ccacctggtc ggcctggtcc gggcggtccg gatccgacgg
      661 gccggacgat ccggatgagc gctggctgac ggcggtcctg cacatcgcgt tcttcctgct
      721 gctggggtcc tcgctggtcc gctatctgat ccgggacacc ggcggcgcgc cgaacggctg
      781 ggtcatcgcc ctcttcgtgg ccttcggcgc gctctatccg cccggacggt ggccggcgcc
      841 cgcgccgggc cccggcggcc gtccctccgg ccgctatctg gtctggctga ccgcggtgct
      901 ggccgcctgg gtcgcgctgc tggtcctcgc gccgagcgcc gcatggtgcg ccatgccgct
      961 gttcttcacc ggtctgcaca ccctgcccac ccggttcgcg gtgcccctgg ccgccgtgct
     1021 caccgcgctg gtcgtcgcct ccaaactgcg gttcatgcac gacggcttcg atcccaacgc
     1081 gctgatcgcg ccgcccgcca tcgccgccgt ggccgccgcc gtcctcatcc atctgcggcg
     1141 ccagtcggcc cggcagcgga cgctgatcga cgatctggtc cgcacccgcc gcgatctggc
     1201 cgcgaccgag cggcgggcgg ggatcctggc cgagcgccag cggctgtcct cggagatcca
     1261 tgacaccctc gcccaggggc tgtccagcca gcggatgctg ctccaggccg ccgaccgcac
     1321 ctgggagacg gatccgcagg cggcccgcgg acatatgcgg gacgcggcgg agatcgtgtc
     1381 ccgcagcctc gccgaggccc gccggttcgt ccaggacctg gccccggccg acctcgccga
     1441 gcgctccctg gcccaggcgc tcggcgcgct cgccgagcgg gagagcggcc cggggcggac
     1501 ggtggacttc cggctcgacg gccccctcgg cccgctgccc gagcgggtgg cggccgcgct
     1561 gctgcgcatc gcccagggcg cgctggccaa tgtgcgggag cacgccgggg cgggccgggc
     1621 cgcgctcacc ctgacctgga tgggcgatca gatctgtctg gacatcgccg atgacggccg
     1681 tggcttcgac accggcgccg tcccggcccc cggcgcggac cggtcgcgcg gacacgggct
     1741 cccggccatg cgggcccggg tacggcagct gggcggcacg ctcaccgtgg agtccgcacc
     1801 gggcgagggg accgtggtct cggccgcgat ccccgtggag cccctctccg ccctcgtccc
     1861 cgaccgcccc gtggaggtca cgccatgagc ccgtccccgt ccccttcccc gtccccttcg
     1921 tcgccctcgt cgtccggccc ggccgcgggc ccgtcgccgt ccccctcgtc cggccccgct
     1981 ccgagcgtgg ccccgtccgc gcccgccatc cggctgctgc tctgcgacga ccacgccgtg
     2041 gtgcgggccg ggctgcgggc gctgctggcc agcaccgagg ggatcgaggt ggtcggcgag
     2101 gcgggcagcg gcgaggaggc cctcgccatg gccacccggc tgcggcccga tgtggtgctg
     2161 atggatctcc agctcgggga gggtatggac ggggtgaccg ccacccggcg gctggtccgt
     2221 ggcgatccac ccgcgccccg cgtcctggtg ctcaccatgt tcgacaccga cgccgacatc
     2281 acccgtgcca tcgaggcggg ggccaccggc tatctgctca aggccgagcg cccggaggag
     2341 ctgttcgcgg cgatccggaa cgccgcctcc ggccgtaccg cgctgtcggc cccggtcgcc
     2401 gaccgggtgc tggcccggat gcgcagcccg cgccccgggc tgtccgagcg ggagcgcgac
     2461 atcctccggc agctggcccg cggcctgggc aaccgggaga tcgcccgggc cctgttcatc
     2521 agcgaggcca cggtcaagac ccatctggga cggatctacg ggaaattggg ggtcgagacc
     2581 cgggccgggg cggtggcggt ggccaccgag cggcggctgc tgccctgacg gcgtcagatc
     2641 gccgggcggc ccggcagcgg aacgcggtcc tggtcgggca ggacgagcgt acgcgtgggc
     2701 agcgggatct cgatgccctc ggcgcggaac cggcggtgca gctccttcat gaactcatgc
     2761 ttgatgaggt actggtcgct gaactccagg gcccgcagaa acaccgagaa gtcgatgccg
     2821 gactctccga aggtgtggaa gcgcacgctg gcctcgtggt cgacgacgcc gccctcgaca
     2881 ccggacatca ccttcccggc gacctcgacg gtcacccgct cgacatggtc cagatcgctt
     2941 ccgtagccga ccttcgcctg gaccatgacc gacatctgct gctcgggctg gtgaaagttg
     3001 gtcatgatgg tgttgcccag cttggcgttc gggatgatga cgaggttgtc cgacagctgc
     3061 cgcaccgccg tgttgcgcca gttgatgtcg accacatacc cctcctcccc gctgctgagc
     3121 cggatgtagt ggccgggctg caccgtcttg gaggccagga tgtgcacccc cgcgaagagg
     3181 ttggccaagg tgtcctggag ggccagggcg accgccagac ctcccacgcc cagcgcggtg
     3241 agcagcgggg cgatcgagac gcccagcgtc tccagcagga tcagcacacc catcgccagt
     3301 acggcgatcc gcgtgatgtt gacgaagatg gtggccgtac cggccacgcc tgagcgggac
     3361 agtgccagtg agcgcaccag atcggccacc actcgcgccg ccgtggcggt ggtgaccagg
     3421 atcagagcgg ccaccagcgt ctgatcgacg tcatggccga ccgcgggggt cagcggcagc
     3481 gcggcggccg cggcggccac accggcggcc atcgacgccc acggcgccag ggtgcgcaag
     3541 gtgtcgacga tgatgtcgtc gccgctccag cgggtggcgc gggcccgctc acccagccag
     3601 cgcagcgcca ggcgcaacaa cacaccaccg gccgcgccgc ataccagggc cgccccgacg
     3661 acgatgacat cgtgcaaggt gagagcccgg ttcatcgacc actctccccg gtgccggaca
     3721 gcgcgtcaga agtggccgta cggcatgccg tcgtcggtgc ggcctccggt ctggaggtct
     3781 gtggaatcac catgtcacct gcttgtacct ggggtgtacg ggctgtgccg gcgtacatgt
     3841 gtacggctcc ggcgtgaggt gccatcctgc cgcatgggat gagggccgaa tgacgggatg
     3901 ccccgctacc gcacgtaacc cgccaggtgg cgggcggcgc gtcaccgcgt ttgacggaca
     3961 tgtgatgtgt ggtggaatca gatcacatgg aaagccgtcg aaacgacgtg agcagagcgt
     4021 ggccgtatct cgcggccgcc tacgccttcg tggtcacgat gtgcggtacg acgctgccca
     4081 cgccgctcta ctcgctctat cagcgggagt tcggcttctc ctcgttcatg gtcacggtga
     4141 tcttcgccgt atacgcggcg ggggtcatcg tcgcgctgct gctgctcgga agcgtgtccg
     4201 acttcatcgg gcgacggccc gtcatgctgg ccgcgctggt gctgtcggcc ctgagcgcgg
     4261 tgtgtttcct gctcgcccgg ggactgccgg agctgttcgc gggccgcacc ctgtcggggc
     4321 tgtcggccgg tctggccacc ggcaccgcca ccgtgacggt gatcgagctg gcgccgccga
     4381 gccggcgccg tgccgccacc ctcctcgcca ccggggccaa cctgggcggt ctcggcgtcg
     4441 gcccgttgct ggcgggtgtg ctggcgcagt acgccccggc gccgctgaag ctggtgttcg
     4501 tggtggacct ggtgctggtg gcggtggccg ccgccgtggt gctcgccctc ccggagaccg
     4561 tacggacgcg gagccgtccg ccgctgaggc cgcagcggct gcgggtgccc aaggagatgc
     4621 gctcgacgtt cgcggccgcg gccatggcgg ggttcgcggg cttcgccaca ctgggcctgt
     4681 tcacctcggt gtcgcccacg ttcctgagcg aggtggaggg ggagagcaat ctcgcggtcg
     4741 ccggtgccgt ggcgttctcc gtgttcgccg cctcgatcgc cgggcaggtg ctggggcggc
     4801 ggctgggccc ggggtggtcg ctgcccggag ggtgcgcggt gctggtggcc gggatggcgg
     4861 ccatcgcggt ctcgctggcc atcgcgtcgc ttgcgctgct ggtgctgggc gccgtggtgg
     4921 cggggacggg ccaggggctg tcgttccacg cggccgtacg ggtggtgacg gagcgcagtc
     4981 cggccgaccg ccgcgccgag gtcacctccg ccctcttcgt gctgatgtac ctggcgatct
     5041 cgattccggt gatcggcgtc ggcgcgctga cggtcgcggt cgggctgcgg accgccgggc
     5101 tcgtcttcac gggctgtgtg gctctgctgg ccgtggccac cctgctgcgg gtgcgggcgc
     5161 tctcggcgga gacggccgac cgctgagggc ccgccgaccc gtcgatccgc ccccggagga
     5221 gcggatcgac ggcgtccggc gcggccgccc ggcgtcacag ctccaggacg gtccgcaccg
     5281 gcagatggtc gctggggtac tgggtgtcct gggagaaggt gtcgatggcg gcgtggcggg
     5341 tgcgcacccc cggcgaggtc aggatccagt cgatccggtc gccgtcgggg gtcagcgggc
     5401 cgaagccgtg gaacgtcccg tacagcgggc cgcgccgctc ggcggtgtcc caggtgtcca
     5461 ccagcgtccc gccgttcagc atggcgtcgt acaccgggtt gccatgggcc gccacattga
     5521 agtcgccggt cacgatgcgg gggagcgcgg agtccagacc gccgagccgc tcggtgatca
     5581 gagcggcggc gtgctcacgg gcgttctggc cgcggtggtc cagatgggtg ttgagggcgt
     5641 agaactcctt gccggtgtgc cggtcgtgga agcgcaccca ggtgaccatg cggaccacgg
     5701 ccccgcccca ggtgttggaa ccgatcacat tcggggtgtc ggacagccag aagtggtcgt
     5761 actccagggg ttccagccgc ccggtgtcgt agaagacggc catgaactcg tcgcggctgc
     5821 cgcccatccg cccgacgccg atccaggagt agcgctgccc gaggtcctgg gcgatatcac
     5881 gcagctggcc gtacagcccc tcctgagtgc ccagcagatg gggccgggcc cggcgcagca
     5941 gctcccgcat gaccgggcgg cgccggcccc aggagttggg ctcgctgtca ctggcgtagc
     6001 gcagattgaa ggtcatggcg gccagccgtg gaccgtcggc gggggcgacc ggggcggcgg
     6061 ggaccgccgt ggccacgtac tgcggctggg cggcgagcgg aagcgcgacg gccgccgcgg
     6121 ccgcgacgcg cataccgcga cggcggctga acacaggtgc gggcatggct cctccaaggt
     6181 cttgaaggtg cggtgtcggc ccaagtgtcg gcccccgcgg tgtggggggc gtgtcctgcg
     6241 gtggccgtcc ggtggaacgt acggtcacgc cgagccgacc tcaagagcgc gggtggcctc
     6301 cgcctgtgac gagaagtccc accagtgacg ggagacctca ccagtgacgg gggtggccgg
     6361 gggtgcgcgg cggtggcggt gggtagacag ggtcggtagt cgtcgagacg gaaggggcac
     6421 ctggggtgag cgtacggccg ctgaccttcg tcgtggggac cggacgatgc ggttccaccg
     6481 cactgtcgcg cgtcctgcgg ctgcatccgg atctgctcag cgtgagcgag ctgatcgcct
     6541 cgctggagcc ggacgcgctg cccgaggcgc cgctgaccgg ggcggagttc tggcggatcc
     6601 tcgccactcc gcgctcgttc gccaaccgcg tcatccgcga tggcatcccg ctgccggagt
     6661 accggtatcc gcatgtcgag gggcggttct cggtgtccgg cggtggcatt ccggccgtgt
     6721 gcatgatgac gctgccgcat ctcaccgacg accccgacgc gctgttcgac gcgctggagc
     6781 cggagctgtc ccggcggccc gccgccccgg tggccgatca ctaccgggca ctgttcggcc
     6841 tgctggggga gcggttcggc cgacgcgccg tcgtggagcg gtcgggctac tcgctgcggt
     6901 cggtgcctcg gctgcgggag gtctttcccg aggcccggtt catccacctc caccgggacg
     6961 gcgccgactg cgcgctctcc atgagccgcc accccggctt ccggctgatc cagctgatga
     7021 cggagcgcgc cgagaccacc gaggaccttc cggccggtct cgacgcgctg ctcagcgacg
     7081 acgacgccga tctgcgcccg ctgtaccaac ggtcggtacc gaccgccgag ttcggccgtc
     7141 tgtggtcggc cacgatcgtc gaggggctgg agcgtctgtc ccggctcccc gccgacatcc
     7201 ggatgtccct gtcgtacgag ggcctcctcg acgcgcccga gcgcgagctc acccggctgg
     7261 cccaccacgt cggggtggaa cccctcccgg agtggctggc ggccggacgg gccctgctcg
     7321 acggcgaccg ccggggcacg gccgccgcga ccctgccgcc cgccgaactg gccgccctcc
     7381 gcgaaagctg cgcccccggt gcgcgggcac tgagcgccgt ccacggcgga tgagacgggc
     7441 cccgggtcgg gtgcacgtcg gacagagcgg gccttgagcc gggtgtacgg cggagggggc
     7501 gggtcttggg ccgggtgcac ggcggatgag acgggccccg cccggcgcac ggcggaccga
     7561 acgggtcttg agccgggtgc acggcggaga gggcggtcct tgggccgggt gcacggcgga
     7621 ccgaacgggc cctgagccga gcgcacggcg gatgagcctg gccaagacgc ccggcgaacg
     7681 ccggagcccg tcttcgggcc ccgtgcgtgg cggctgagcc cggcccgggg ccgatgaggt
     7741 agcccggcgt cgggccgtcg ccgctcaggc ggcatcccgc gactgctcga cggccaccgc
     7801 ccgcagcgcc tccagcaggg cggccaccgc gggcaccctg gccgcctccg gccgcagcag
     7861 cgcgcagacg tggcgccggg gccagtcgtc cagcggacgc ggctcgaccc gaggatcgca
     7921 ccgggggagc agacccaggc cgtccatcag ggcgatgccc accccatcgc ccaccaggcc
     7981 cagcgtcgtc gcctggtcgt cggtcgtggt caccacccgg ggctcgaacc ccgcctccgc
     8041 gcagcgccgc agcagccgct cgcggtcccg ctccaggatc caccgctccc gcgacagatc
     8101 ggcgaggcgg acgctgcgcc gccccgcgag cgcatggccg cgcggcagca gcacatggcg
     8161 gcggtcgacc agcagcggga cccggcgcag cggggtgacc gcgggccccg tcgcctctcc
     8221 cgtcgcctct cccggctcgt cgtcggcgac gatcgccaga tcggtctcgc ccgagtccag
     8281 cagccggtac gcgtcctggg aggcggtctg gcccagctcc acctccacct cgatacggga
     8341 ggcgcccagc ctggccagcg cggcgggcag cacggcgaca ctgacgctct gcacggagga
     8401 catccgcacc cggccccggg tgcgcgcggc gagcgcctcg aactcgttct ccacgtcccg
     8461 cagcccggcc agcaccccct gggcgcgctc ggcgagtctg tggcccgccg gcgtcagccg
     8521 caccccccgt cccgccttga ccgtgagcgc catgcccacg gcacgttcca gcgcgcgcat
     8581 gtgatagctg atggccggtt gggtgtaccc gagactgtcc gccgcggcgc tgtaggagcc
     8641 ggcgcgacag acttctgtga gcacggtgag ctggcgaaga tcgatcacta caggaagata
     8701 aaaatcgttt atcaattccc ggaagacttt aattggacga gtgatcggga gaccgtcaaa
     8761 atcatggtga cggatttcgc ccgaactcgc tcatcgaact gaccgatcgg acacggtccc
     8821 acccgcactg gctgaccgta cggtcacagc ccgcccacaa cggtttcctc cccgacgatc
     8881 cggccggacc ggcaagggga accgggcgcg gtgacattcc tccctccgcc cgaccccccg
     8941 ctggaatgga tggatggtgc ccgatgcatg atggctggaa tcgcatgact ccggtggtgg
     9001 cggagaacaa tcccttccac cagatgtcgc tcaacgaaac cgttcacccc ccgctccccg
     9061 aagtggtgga cgccgtcctg cgcaccgcgc ggaacgccca ccgtaccctc gatgccctcg
     9121 gcaccgggct gtgtcaggcc ctcgccgcgc atctgggagt gggcccggag cacatactcg
     9181 ccggaccggg ctccggcgcg ctgctccagc agctgttctc caccctcacc ggacccgaca
     9241 ccgacacggt gcacgcctgg ccctcatggg aggcgtaccc catgatggcg gccaacgccg
     9301 gatccaccac cgtgcgggtg ccgctctccg gatacgacca cgatctgaag gcgatggccg
     9361 acgccgtcac cgaccgcacc cgcatggtcc tgctgtgcac ccccaacaac cccaccggca
     9421 ccgcgctgga ccaggagcgg atcctgcgcc tgctggaccg gctgccggcc catgtcaccg
     9481 tcgtcatcga cgaggcgtac cgggacttcg ccgaccccgg cgccatcgcc gacggcatcg
     9541 cactgcaccg cgccgatgaa cgggtctgtg tggtgcggac gttctccaag tcctacggac
     9601 tgctcagcct gcgggtcggc tatctcgtgg cccatgagcc cgtgctcgcc ccgctccgct
     9661 cggtcctgcc cttccaccgg gtgagcgccg tggcacagga ggccgccatc gccgcgctcg
     9721 gcgcccatga gcgggtgctc gggcagtgcg cccggaccgt cgaggagcgc gagcggctcc
     9781 accggaccct gctcgaccag ggctgggagg tgcccgcgag ccagggcaac ttcctctggc
     9841 tgcccatgac ctccggtgtg gagcgcttca cccagttctg cgcggaccac ggcgtggtgg
     9901 tgtgcggcaa accgggcgaa ggcatccggg tcaccgtcgc cgagcccgcc gccaaccagg
     9961 cgttcgccca actcgccgga aagtaccggg aggcgaccgt atgaccccgc ccgatgtcgc
    10021 ggtcaccgag gtggccgacc cgctggcgga ggccgccccc accatggagc tcctgctgcg
    10081 cgagctcgac cggcgctggc cgcgggaggc cgaacggctc caccggatct cccggtacgc
    10141 cctgctcccg gcggggaagc tgctgcgccc gctgctgctc atggaggccg cagaggcggt
    10201 gggcggcggc ggacccgccg tcgtcccggc cgcgctgagc gtggagtacc tccatgtggg
    10261 atccctcgtc cacgacgatg tcatcgacgg cgacgccatg cggcggggcc gtccgtccgt
    10321 cgcggcgcgc cacggcaccg ccgacgccat cgtcaccggg gacgccctga tgctgggcac
    10381 gttcggcgtg ctcaccgacg gcaccgacga ggcgggcggg ctgccgccgg gccgggtcct
    10441 cgacgccgta cgggtcttcg cccaggcggg cgtcgatctg tgccgcggcc aggcgatgga
    10501 ggccgaactc cgcggcgacc tcggctgcgg actcgaccgg tacgtcacca tgaccgccct
    10561 gaagaccggg gcgctgttcc gggccgcctg ccggggcggg gcgatcctgg gcggcggatc
    10621 ccccgcccag cggcacgcgc tcaccgccta cgccgaacac ctggggtcgg ccttccagat
    10681 gcacgacgac ctgctgccgt acaccagcga cagccgcacc accggcaagt ccgccctcag
    10741 cgacatcgcg gccgcccggc ccaccttccc cgttctgctc tgccacgcca tggccggtgc
    10801 cccggcctgc gcccggctgg aggcggcgct cggcggcgcc ctgcccgccg ccgacgcgct
    10861 gcggacggtg cacgaactgc tggagacgac cggcgcgctc gacgccgcgc gggaccgggc
    10921 cacggcccag gcggacctgg ccaagtcctg tctggcggaa ctgccccgct cccgggccac
    10981 cgccgtgctc gcggcggtgg ccgatctgtc ggtcagccgg gaccggtgac gccgtggcgg
    11041 ccccgcgcac ggcactcctc gcccatctcc agacctggcg cccgtacacc ctgtggtacc
    11101 ccggtctggt cggactcgcc ggagcctcgc tcaccggatc gcaccccacc acggggcagt
    11161 tgacggtggc ctgggccgcg ccgaccctcg gctgggtcgc cggccactat ctcggcgact
    11221 actacgaccg tgacctggac gccctcagca agccccaacg ccccataccc tctggacggt
    11281 tgagccctcg tacggccgtg gccgcgggta tcggctgcgc cctcgcggtg gccgcgctgg
    11341 ccctgtgggc caactggcgc gcggtggccg tggccgccgc cgccatggcg ggcatcgtgg
    11401 cctacagccg ggtcctcaag gggcgtggtc tgccgggcaa tctcgtccgc ggtgtgctga
    11461 ccgcgctcac cgtgctgttc ggcgcgatgg ccgtccagcc gtggccacca tggcggacgc
    11521 tgcccttcgc cctggtcttc ctggcccatg acaccgcgtc caacctcgtc ggcaccctcc
    11581 gcgacgtcga cggcgaccgc gagggcggct acgccaccgt gccggtacgc cggggcgtac
    11641 ggcgcgccac gcacaccgcg gccgcgctgt atctgaccgc cgtggccgtg gcctgcgccg
    11701 ccaccgggct ggtgcccgag gacacggccg gctatctggt gctgctgtcg gcggcggcgc
    11761 tgtgcggcgc gggcgtcttc gggctgctgc tgcggtcgcc ggggcacctc accccggcgc
    11821 tggcgctgcg cgcccacgcc gtcctcgtct gcgaacgcct ggtactggcc gcggcggtgg
    11881 tggccgcggg cgccggcgcc gtacccgccc tggcgctgct gacgccgctc ctcgcggtca
    11941 gcgtcatcac ccagagccgg atgcggtccc gccatgagtt ccccgcccct ctggccgatg
    12001 gccggcccac cctccccgat ccacgtccct gacacggcgc gccaccacca gaagggtccg
    12061 atcccatgcc cccttccgcc ttgaccgaga gcgtcggcac ggccatcgtc gccggtgccg
    12121 aggcgctcct ggcccatcgg cgcgacgacg gcgccttcgt cttcggcgcg caccacgcct
    12181 cgccgctgaa caccgccgga gccctcaccg cactgcactt cgccgatccg gagggctcgg
    12241 ccgagaccat cgagcgcggt gtcacctggc tgtgcgagac ccagcgggac gacggcggct
    12301 gggccatgcg ctcggtgccc accgaacccc tcaccaccgc gctcgccgcc gccgcgctcc
    12361 aactggtggc cccccgccgg gcggcgtcgg cggtacgcgc cgcacgggac cggttcgagg
    12421 agctcggcgg gtccgcggcc gtcccggaac ccgtgatgac cgccctcatc cgccagttcc
    12481 acaccttcgc cgggctgccc catgagggcg cccagcgccg gctccccctg gaactgctgc
    12541 tcctccccgg cctcagccgc cgtctgctca gcctgcggct gcccatctac gccggccagg
    12601 cgctcgccca gtccgcccac cgccgccgcg gcccggtcgg ccgcgccctg gaccggctgg
    12661 cccgccccag ggccctggcg atcctccgtg acgcgtacga acgcgagggc gccaccggcg
    12721 ggttcagcac cgacccctgg ctcaccggac tcatctgcct gggcctcgcc cgctccggac
    12781 aggcgcccga cctggtccgc gccgccgccg gctggctccg ctcggcggcg cgccccgacg
    12841 gctcctggga tctgatgccg ctcgatgtga cctggacgaa cttcgccacc gccgcgctga
    12901 tcgaagccgg tcgcgccgac gacccccagc tgatcggcac ccgcgagatg ctccaccgcc
    12961 accagcagcc cgagtcgttc gacgcgctcg gctgcccggc cggctactgg gggttctcca
    13021 gcccccgcag ctggccgatg gccctggaga cggccgagtc cagcgccatc ctgctgcggc
    13081 tgcccggcgg cgcgtacgac ccgcatgttc gcgccggact ggcgtggctg accgccaccc
    13141 aggacgcggc cgggtcctgg agcctggccg tgcggaacac caaaccgggc ggcttcggac
    13201 cctgccccca gatgaccgcc aagatcgtgg gcgccctgct cgactccggg gccggggccg
    13261 acgacccgcg cgtggccaag gcggtgcggt ggctggtcgg ccggcagcgc ccggacggat
    13321 cgttcgatgc catgtggtac cgcggcggca cccccggcac cgccgccgcg ctggaggcgc
    13381 tcacccgggc gggccacacc gaggagcacc gccgggcggc ggcccgggcc agggactggc
    13441 tgctgcgcac ccggcacccc gacggctcgt ggagcaccgg cgagggcacc cggcccggca
    13501 ccgtggagga gaccgcctgg gcactgcgcg ggctgctcgc cgccaggtcg agccccgccg
    13561 acccggccct cgcggcggcg gcccgctggc tcgtcgacgc ccagcgggcg gacggcggct
    13621 ggaacccggc gccggtcaac gagtacatcc gcggctgtgc ccgctacgcc gacgacggca
    13681 tcgcggcggg cctggcgctg cgggccctgg cccactaccg ctccgcgacg gccaccacca
    13741 cgacccgcac gaaagacatc acaggcgacg gcgaaggagg caggccatga gccccgatgt
    13801 gctggtgtgc ggggcgggcg tcggcggtct cgcggcggcc cgcgcgctcg gcggcctcgg
    13861 actggacgtc ctggtggtcg acaagcagcc gaggatccgc ccgatcgcca agggagaggt
    13921 gctccagccg ggcgcgctgc gtctgctgcg ctcctggggc gtggagcagc ggctcgacgc
    13981 ccagggcgcg gtccggctcg gacggctggt cgtccgcgat ccgcggggca ccgcgctgat
    14041 gtccctcgac tacggtcaac tgcccgcccc cgaccagtgg ttgctggccc atgaccacac
    14101 caccatcctc accgccctgg ccgaggggct cgggccgcgc gtcgaactgc gccggggcgt
    14161 ccgcgcggag ttgccgctgc gcgacgactc cggccggatc accggactgc ggctggccga
    14221 aggcggcagg gtctacgagg agcgggcccc gctcgtggtc gccgccgacg gcatctcctc
    14281 acggctgcgg tcctgggcgg acatcgaggc caaacggatc gactacccgc accggctggt
    14341 ctccttcgac atcgccgacg ccgaagccgc cgcgcgggcc gacgacttct ccgcgtacgt
    14401 caccgaccgg gggctgcgcc tgctctatcc gctgccgggc ggccggctgc ggctctacct
    14461 ccaggccggg cccgatgagc tgcgcggcgt cacggcgcgc ggggggctgg ccgactgggc
    14521 cacccgggcg ctgtcccagg tacccgccct ggagccgctg gccacctccc tgctcgccca
    14581 tctcgacacc cggcagacgc tgcccgtcgg acggctgctg tcgccccggc tggccgggca
    14641 tggactggcg ctggtcggcg aggccgcgta cgccgtccac ccgatggccg cgcagggcat
    14701 gaacaccgcc atcaccagcg ccggcgccct cgccgagcgg cttgcggacc ggctggagcg
    14761 gatgggcggg atgtcggccg cggcggtgga cggcgcgctg tgcgactacc acgaacggca
    14821 gctgcccctt ctcgcccagg cggccaggac cagcggcaac gcggcgcgga tggtcaccga
    14881 tctgtcgtgg cgcggccgga tcctgggccg ccgggcggtc cgccacaccg gggccaaccc
    14941 ccggctgctg cacaccgtca cccacaacat gtcgggcctc ggcccccgcc cgctgacccc
    15001 gctggaccgg cttcagcagc tcggtctcgt ccccgatccg cgcgcccacc gagtgccggc
    15061 cgcaccggcc ggccgaccgc aatccatgtg aggacggttt atcgcatgcc cactcccgaa
    15121 ctggccgtga cccccgtctc cggagcgctc ggcgcggaga tccgcggtgt cgatctgacc
    15181 gagctcaccg acgaactctt cgagcgcatc tatgagttgc tgctcgagca cctcgtggtc
    15241 ttcttcccgg accaggaaca cctcaccccc aaggcgcata tcgccctggg gcggcggctg
    15301 ggggagctgg aggtccatcc gttcctgccg aaggccgacg gccaccccga gatcgtcgtc
    15361 ctggacgcgg accagggcgc caaggccgac gagtggcata tcgacgtgac cttccagccc
    15421 aatccgccgg tcgcctccat cctccatctc caggtgtgtc ccgcctccgg cggcgacacc
    15481 atgtggagca accagtacct ggtctacgag acgctctccg agccgatgcg cgaactcctc
    15541 gacgggctca ccgccgtcca cgtcctcaac acaccgcaga ccggcgagca ctccgccgaa
    15601 cacccggtgg tgcggatcca ccccgagacc ggcaggcgct cgctgtatgt gacgcgcatg
    15661 tggacctcgc acatcccaca gctcagccgc ccggagagcg acgccctgct ccagtacctc
    15721 ttcgagcact ccgagtcgcc ccggttcaac tgccgctacc gctggcagcc cggcgcggtc
    15781 gcgatgtggg acaaccgcgc cacccagcac ctggccgtca acgactacac ggggccccgc
    15841 aggggacagc gggtgaccgt cctcggcgac caccccaccg gcgacacccc ccgctggaag
    15901 gagtaccggc ccgcgcccga cgagcgctac tacccgcgcc atgtcacggc ccggcacggc
    15961 tatcggtgac agcccgtcag cggcccgggc gccgccgccg tacggtggcg gcgacccccg
    16021 cgcccagcac cagcacggac gcgccaccgg cgagcagcac cggagtggtg gtgccgccgt
    16081 cgtccgcttc ggccgcggag gtggccgggg agggcggcgc gtcgccccgg gacggcgggg
    16141 cggtgacctc caccgacggg gccgcggccc cgtcggacgg ggtggcgcgc cgctccggcg
    16201 agtccttcgg gcccttcccc gcggcggcgc tcagcaccac gtcggagcag gagtagtagg
    16261 tgtccggggt gctggtgttc cgccagatcg tgtagagcag ctgacggccg gcccggccgg
    16321 cgggcagcgt ggcctggatg cggtacgcgt cgtccaccag cgcggggtcc ttggccgtgg
    16381 cgaacggctt cggctccaga tccgaccacc tcagcggccg ggtgggagcg tagccctcct
    16441 tggtgagata cagctcgaag gtccccgtgt gcgggatcgt cgaccggtag gtgagcgtga
    16501 gcttcgctcc ggccgaaagc cgggtcgagg gccagtcggc gcgcgccagg tccagacccc
    16561 ggtacgcctc caggcccccg ctgcacagct ttccgtccgg gacccgctcc cggtccccgc
    16621 cctcgacccc ggcgatccgc agattgtccc agtccgccgc ctccgggcca ttggcggccc
    16681 gggccgcccg gcacgcggcc gaccgcgccg cggccccgcc ctcgggtgag caggcgaacg
    16741 tccggctcac cggatccgtc ggcgccccgt gtgcctgggc gggctgagcg gccagcgccg
    16801 tgaacagaca ggggagggcg ccgagaagag cgcccacggc ggcggtgcgg tgcgaggtca
    16861 tccggtgcgg ccctccagct cggtgcggcg acgggcggct cgcccgtccc gggggatacg
    16921 ggaggcccgg cccgtgcgtt caacgggccc ccggaagccg tggcatgacg ccgtacaacc
    16981 atccacgagc tccgcatgtc tccctaggca gacgcaaaca gcgcctacgc ccatgaagaa
    17041 tcattaaggg ggacaaatga atctttctcg ccgtatggcc gccaccgcgg tcctcgccac
    17101 cgccgccatc gcgggcaccg tggccatcac gccgcaggcg tcggccgccg ccacggccac
    17161 gtacaacggg gtgtgcggca ccggatacaa ggtggtgaac tcggcgccca tcggctccaa
    17221 gggcaccgtc ttcctcacct acaactccgc caagggcaag aactgcgtgg tcaccgtccg
    17281 gaacgccacg ggcaagccgg ttcccatgtt cgcctacctg tacgttcagg gagccgacga
    17341 gtcggccgag gacggcggcg cgtacacctc gtacgcgggc ccggtgtacg gcgacgggcg
    17401 tggcaagtgt gtggactggg ccgggggcat cgagaaccag tccacctgga cctacggatc
    17461 gaactgcgga tccctgacgg cccaccgcgt gaccaagggc tggtaggcgc aagcccggaa
    17521 gccacgcgcc gatcgagccc accgacgggg gaacgcacgg gggagcggcg gccatctctg
    17581 tggggtggcc gccgcactcg tcgtacgggt actagcgctc ggtgaaggcc accgcgcggg
    17641 tgtccagcac gatgtggagc tgtgcgagac ggtaggcggc accgtcggag cggaccacac
    17701 agcgcaccac gcccccggcg atcggggtca cctggccctc ggtgatattg gtggcgtaca
    17761 tataggacac caccgagata tcatcgccgt cgacccgctc gatgtggatg ttcgaggcgt
    17821 tgtggcgcag cggatagccg gccgcctcgc ggtgcttccg ctgccaggcg atcacctgct
    17881 cacggccctg gttgtcggag gcgatgaact cctcgtacgg ggacttcccg gtgtccgagc
    17941 gggaggtgat gtgcacgtcc tcggtcagca gctcgggcca gacgtcgaac tgcccctcgt
    18001 cgaagacgaa ccaccagcgg tggatcagct catggaccgc cagacgatcg agcatacgga
    18061 gctctccccc cgaggattca agtgatcgac agcatatccc gggggtgtcg gccgacgagg
    18121 tcccggatgc cgaaccgccg ccggagtccg gtgcggcccc cgccgggcgt gcggaagaat
    18181 tccgtgaagc caccgaccca tcggtatgcc gatggtgcaa tagcggggca ggctctggta
    18241 tcaaacctgg ccgtggcctc acgctgccgc gtcgagctgc gctttcgccc gtcacaggtg
    18301 gaggaacgtc tatgcacccc gtcaccggct cccgcgcttc cgcccccgcc atgggccgcc
    18361 cggccccccg ccggtccgcc gaccggggcc gtacaccgcc ccggatgccc gccgcccggc
    18421 cgccgatccg gtcgcgggcc gacgccgaga ccgtggcgct gctgcaccgc accgcccgtg
    18481 tgctcatcga ggaggtccca cggctgacgg accgtatcgt cacgctgatg aaggagcgcg
    18541 agcccgtcta ccggtcgccc tccctcgacc cgcacgaggt gtggcgggag gtccacgatt
    18601 cgctcagcca caatgtgcgc tcgctggtgc gccccaagga gacgcgcgaa tcggccagat
    18661 cctgcgcgtg gcggatcggc accgaccgcg ccgcccaggg ctttccgctg gacgcgctgc
    18721 tgcacgcgta ccgcatcggc tgcaccgtcg tctgggagcg gctcctggag accgcatcga
    18781 aggaggaccc gctgggcgcc caggcgctgg tccatgtcgc cgccgacgta tggaacttcg
    18841 tcgacgagca ctgcaccctc gtcgccacgg cgtaccagga ggtcgagcgg cagctctcct
    18901 ggcaccggga gaaccgctac cggatcatcg tcgccgctct gctcgacggc accgcccggg
    18961 tgaccgactt ccccgaggcg gaggaggtcc tcggcctgcc cgagcggggg cgttacgcgg
    19021 tcgtggcgct ggagggcacc gatgccccgg cgcgggcgcc gcaccccgtc accgggctgt
    19081 gcgccggtct tcgcacggtc tggcacacgg cggagggcat cgcccacgcc atcgtgctgc
    19141 tcggcgacac cgacggcgac ggcggtgatg gctacggcgg cgacggcgat ggcgtcggtg
    19201 tggagcggct ggtgcgcggg ctggagctgc cgcccggcgt acgggccggg gtcagccccg
    19261 ccgtgaccgg tctggccgcg gtcaacaccg cccgcaggct cgccgatacg gcgctgcgca
    19321 cccgcccggc cgccggggag gcggcgctgc tggaggagcg ctatccggag gcgctggtgg
    19381 tgtcctcccc ggaactcggc accgcgctcg ccgaccggat gctcggaccg gtcctggcgc
    19441 tggagcccgc cgaccgggag ctgctgctga cgacgctggc cgcctggctg gaggccgatg
    19501 ggtcggcgcg ccgcgcgggc gagctgctgt tctgccaccg caacacggtg ctcaaccggc
    19561 tgcgccgcta tgagcagttg accgggcgtt cgctggaccg cccccgagag gtgatggagc
    19621 tgtcgctcgc gctgtccgcg caccggctgc tgacctcctg agcaccggct gcccgcccga
    19681 gacggtgtgg gcgtgcacaa cggccccgcg ccgatcatgt gcgcccgtca cacggtccgc
    19741 cggttggcct gtacgccacc gtgctgacct gctgtcgtgg cgattccgtc ccggtgacgt
    19801 gggacggaat ccgcacaagg agccgcgaca tgtccgacca cgaccacctc tggggttcgc
    19861 ccgtcccgtc cgtcccgccc gtcgggtcca gcgccacgca ccccaccgcg caccgcggcc
    19921 cgtaccgcac cacgcgccgt gccgccacga tgccgcacca cgccacggcg ccgcctccgc
    19981 ctccgccgga gcggcgctcg ccgtggcagc ggccgtggcc ctggccggcg cgggcggcct
    20041 gcgccgcgct cacctgtcat gtggccgcgg tggtggtgaa ctgcgccgcc gagggcgtgg
    20101 tcaacctcgg cgcgggcggc gggttcaccg tgggcgccat gctgatcggc ctggacacgg
    20161 cggtgctgct caccgtcctg gcccgggccc accgccggtc cggcgccgcg ggggaggggg
    20221 agcggtgagc ttcctcgacc ccagaacgct ggcgttcgtg ctcttcgcgg gcttcatggc
    20281 catctcgttc ctgctctgca tcctcgcggc caccggcaat gacgacccca ccgagttcta
    20341 cctcggcacc ggcgcgctca gcccgatgca gaacggcctg gccatcgcgg gtgactacat
    20401 ctccgccgcc accgtgctca gcaccaccgg caccatcgcc ctcgccggat tcgacggggt
    20461 gctcatcgcc acctccaccg tgctctccat cctgctgttc atgctggtcc tcgcaggacc
    20521 gctgtgcgga cgcgggcagt tcaccctcgg cgacgtcctc tccgagcggc tgagcgagcg
    20581 ccccgcccgc gtaggcaccg ccgtcgtggt gctggtggtg gtcctgccgc tgctgctggt
    20641 gcagctcaac ggcgcaggcg acatgctggc gctgctgctc ggcatccccg gaagcggcgc
    20701 ggtcaccggc tgcaccgtct tcatcggctc gctcatggtc tgctacgccg ccctcggcgg
    20761 gatgaagggc accggattca tccagatcct caagacggtg ctgctgctcg ccgcgttcgt
    20821 cctgctcgcc tgcctggtgc tgaggcgctt ctcctggaac ccggtcaccc tcttcgacgc
    20881 cgcggccgac gccagcggct acggcaacgg cttctggcag tccggccgcc agtacggaga
    20941 ctccctcagc ggccgcctgg acgtcatcag cgtccagctc accctcgccg tgggcgcggc
    21001 ctgtatgccc catctcacca tgcggctgca cccgatccgc gggatgcggg ccgcccgcgc
    21061 cgccaccacc tgggcggtcg gcgcggtcac caccatcctc gggctgatcg tgatcgtggg
    21121 tgccggagcc accgccgtcg tgggcgcccg cgccctgcgc gcctccgacc ccaccggcgg
    21181 cgactccctg ctgctgctca ccctcgccct ggacccggcg gcgccggagg cccaccgcag
    21241 cctgctcttc tccgtcgtgg cctgcgcggt cgtcgccacc accctcgcgg cggtcgccgg
    21301 gctcaccctg gccgccgcgg cctccctcgc ccatgacgtg ctggccaagg tcgtcttcag
    21361 gggcaggctc tcggccgacc gcgagctcgc cgccgcccgt gcggccatcg tggccgtcgg
    21421 cgtcacggcc gtcgtcctcg ccatcgtgac ccagcactgg aaccggcagg tcctgatctc
    21481 cttcaccttc gcggccgctg cctcggccct gctgccggtc gtgctctacg gcaccctgtg
    21541 gcgcggcttc acggtgaacg gactgcgctg ggcgctgtac ggggggctcg cgctcaccgc
    21601 cgtggccatg gccttctccc cggcgatctc cggcaacccc ctcgcggtct tccccgaccg
    21661 cgacttccac tggttcccgc tccgcaaccc cggcctcatc accgtccccg ccgggtttct
    21721 gctcggctgg ttcggctccc gtatcggatg ccgggctcgg catgcccagg accccgcgcg
    21781 gggcgacatg ccctacgcga cgcaccccgg ctgacgcgtc gaatccgccg gagtcctcac
    21841 ggggaccggg atccggccct ggcacgccgg tgggcggcca cccgctcccg ggtcgcgcac
    21901 cggcgcgaac agtagcggcg ctccggtccg ctgcccacgg tgaggaagac atcgccgcag
    21961 ccgggagagg agcacagacc gccgggcggg cgctgaccct cccagagcag cacggtcagc
    22021 gccatgcacg acgaggccag gaaccattcg ccccagggcg cctcgtcatc gctgtccaga
    22081 tgcggatgcc agggcgagcg gccgtcgtgc gagctgagcc gcagcggacc cgtgccctct
    22141 cgcagcagcc ggttcagcac cccggcggct tcgtcgacac cgtcggcggt gaacacctcg
    22201 cgcagccgca gcgcggcggt gcgcaggccc gcgacatcat cggcggtgag ctcgagcggg
    22261 ccgagctcgc cgtggtcgag caggatcccg gcgatcgcgc cgggatccgg atccggctcc
    22321 gcggtcaggg cgtttacgag ggcggcggtg cggcgggcgg tggcccgtac cgaatgccga
    22381 gtggaccggt cgtcgttcaa gggtggtgac acgaggtcaa tgtaacgcac ctggcgaggt
    22441 tttgcgttag ctgcgtaatg tgccgcgcat gttggggcgt tacgcgatga ggtgctatct
    22501 gggcggcgcg gccgccgccc gcacggggga cgagatgtcc ggccccgcgc tgctgctggc
    22561 cggaccggcg ctcaccggtt ccgccacctc cggctcgtcg ctgctggcgg gcgtcatggt
    22621 cgcggcggcg ctcggcgggc cgctcttcgg ggtgctgctc gaccgctccc cccggccggg
    22681 gcggctgctg gccgcggcgc tcgccctcta cgcggcggcg ctgaccgcga tcctcctggc
    22741 cctggagcgg ctgccgttcg ccctcacggt gcttctcgcg gtgggtgcgg ggctgctggg
    22801 accggccctg tccggcggct ggacctccca gctgccacgg gtggcgccgc cggggaccct
    22861 gccccgtgcc aacgcgctcg acgcgatgac gttcagcctc gccgcgctgg tggggcccgc
    22921 actcgccggg gccgtggcgg gggcgctcgg ggcgcccgcc gccgtggcgg tgtccatcgc
    22981 gctgatcggc ctcgcgctgc ccgccgcctg ggcgcttccc gcgcctgagc ggcccgtctc
    23041 cacaccgccg cccacctcct cggtccgggc cgatctcacc gccgggctgc gggtcgtcgc
    23101 ccgcaaccgg cgcctggccc gcgccaccgc cacctccgtc atctcctgtg tgggccaggg
    23161 cgcgttgctc acctgctgcc cgccgctcgg cgcggccgta ctcggcggtg ccgaccgtgg
    23221 cgccctgctg ctgtccgcca ccgccgcatc ggccctcgtg gccaacgcgg ccctcgcccg
    23281 ccacccgcgc ccaccgcgcc cggacaccgt gctcctcggt ggcgccctgc tgctcgccct
    23341 cgcgcctctg ctggcggcca tcggccatcc ggccccggtg atcgccgccg cgctgctcac
    23401 cggcgccgcc gaaggcccgc tgctcacggc cctgttcgcg gtgcgccacc gggaggcgcc
    23461 cgagcggctg cgcggtcagg tcttcaccac cggcgccagc ctgaagatca ccggcttcgc
    23521 cctgggcgcg gcgctcgccg gtccgctcgc cgcctggtcg ctgcccggcg ccctggtggc
    23581 cgccgcgggg tgcgcggggc tcgcggccct cgtcttcgta tgctggtcca acggcacgga
    23641 ggctaccgct ccgcttccgc ccccgggggc tgtgtgacgg tgcccatgtc atccatgatg
    23701 acctgcatgg aagatctgaa agacctgctc ccggtcgagg ccgtacggct cgacgtccgg
    23761 gcggccgact ggcgtgaggc gataggcgcc
//
