LOCUS       NZ_CP025018            21191 bp    DNA     linear   CON 12-FEB-2024
DEFINITION  Streptomyces sp. M56 chromosome.
ACCESSION   NZ_CP025018
VERSION     NZ_CP025018.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. M56
  ORGANISM  Streptomyces sp. M56
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11742376)
  AUTHORS   Kim,K.K.Hyun., Klassen,J.L., Ruzzini,A.A.C., Beemelmanns,C.C. and
            Clardy,J.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-NOV-2017) Leibniz Institute for Natural Product
            Research and Infection Biology - Hans Knoll Institute,
            Adolf-Reichwein-Strasse 23, Jena 07745, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-AUG-2014
            Assembly Method                   :: HGAP v. AUG-2014
            Assembly Name                     :: M56v2
            Expected Final Version            :: yes
            Genome Coverage                   :: 94.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/12/2024 06:37:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,558
            CDSs (total)                      :: 9,473
            Genes (coding)                    :: 9,167
            CDSs (with protein)               :: 9,167
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 306
            CDSs (without protein)            :: 306
            Pseudo Genes (ambiguous residues) :: 0 of 306
            Pseudo Genes (frameshifted)       :: 86 of 306
            Pseudo Genes (incomplete)         :: 261 of 306
            Pseudo Genes (internal stop)      :: 28 of 306
            Pseudo Genes (multiple problems)  :: 61 of 306
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:58:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9576394
            Orig. end                         :: 9597585
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP025018.1.
            Annotated using prokka 1.11 from http://www.vicbioinformatics.com.
            Bacteria and source DNA available from Christine Beemelmanns.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21191
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="40"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21191
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21191
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11191](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11191)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            286..888
                     /locus_tag="CFP59_RS39660"
                     /old_locus_tag="CFP59_07844"
     CDS             286..888
                     /EC_number="5.4.99.5"
                     /GO_process="GO:0046417 - chorismate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058754.1"
                     /locus_tag="CFP59_RS39660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07844"
                     /product="chorismate mutase"
                     /protein_id="WP_100808091.1"
                     /transl_table=11
                     /translation="MRPHLSPRHALIAALATAVLATGATAAVAAPAGPAGPARAHGTLR
                     PLVELAAQRVLVADEVAAAKWATDSPIDDPAREREVLDAVARQAEELGADPAATTRIFR
                     DQIEASKVVQRGLYHRWDADPSQAPTERPDLGRIRLEINRINGELVRAIADSAAVREGP
                     SCVGRLTAGTVAVVHGRHLDVLHTVALGRSLPSVCER"
     gene            complement(916..1434)
                     /locus_tag="CFP59_RS39665"
                     /old_locus_tag="CFP59_07845"
     CDS             complement(916..1434)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014155970.1"
                     /locus_tag="CFP59_RS39665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07845"
                     /product="GNAT family protein"
                     /protein_id="WP_100809503.1"
                     /transl_table=11
                     /translation="MRTAVEDDAEALADAYTRNREHLRPSSPRRDESFFTADGQAARLR
                     DQLEQWESGRMVPWVLTGGERILGTVTLSHIVLGPWRNGHLGYWIDAGHLGRGLASLAV
                     RSVCRVADERLGLHRIEASTLVENVPSQGVLLRCGFTRIGMAPDYLHIAGAWRDHLLFQ
                     RVLHDRPAV"
     misc_feature    1437..1451
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.19"
                     /tool="antismash"
     gene            complement(1521..3170)
                     /locus_tag="CFP59_RS39670"
                     /old_locus_tag="CFP59_07846"
     CDS             complement(1521..3170)
                     /NRPS_PKS="Domain: AMP-binding (8-435). E-value: 1.5e-68.
                     Score: 223.2. Matches aSDomain:
                     nrpspksdomains_CFP59_RS39670_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058752.1"
                     /locus_tag="CFP59_RS39670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07846"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_100808092.1"
                     /sec_met_domain="AMP-binding (E-value: 1.9e-71, bitscore:
                     240.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYNLADLFESIVDTVPDREALVYIDHPGTGAERRLSYAQLDAAA
                     NRLAHHLGDSGIAPGEHVGLHLCNGVEYLQTALACLKIRAVPVNVNYRYVEDELVYLYR
                     DADLAALVYDAEFGERVAAALPHTGTLRHLVRVGTGHGPRASVAFGDAEASGSPERGFP
                     ARSADDRFIIYTGGTTGMPKGVVWRQEDLFFSGLGGGAPTGRPVGRPEELAERVAAGGE
                     GLAFFPTPPLMHGTSTLTAFIAFNFGQKVVLHRKFMPEEVLRTIEKEKVTAASLVGDAM
                     LRPLVDALTGPLQGTDLSSLLSVSSSGAILSETVRAQFAELAPHTLLLNNFGSSESGFN
                     GTATADSGPEKGFRLRVNARTTVVDPATLTPVAPGEPGRIAQRGHVPLGYYNDPKKTAE
                     TFFETDGERWVLLGDMATVDEEGVITVLGRGSQCINTGGEKVYPEEVEQALKAHPEVYD
                     ALVAGVPDTRWGHRVAAVVQPRTPASGLTAEAVRDHCRERLAGYKIPRTVVFTDHIQRS
                     PSGKADYRWARAVAQGTDGETPHQDRGAPHPG"
     aSDomain        complement(1866..3146)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CFP59_RS39670_AMP-binding.1"
                     /evalue="1.50E-68"
                     /label="CFP59_RS39670_AMP-binding.1"
                     /locus_tag="CFP59_RS39670"
                     /protein_end="435"
                     /protein_start="8"
                     /score="223.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FESIVDTVPDREALVYIDHPGTGAERRLSYAQLDAAANRLAHHLG
                     DSGIAPGEHVGLHLCNGVEYLQTALACLKIRAVPVNVNYRYVEDELVYLYRDADLAALV
                     YDAEFGERVAAALPHTGTLRHLVRVGTGHGPRASVAFGDAEASGSPERGFPARSADDRF
                     IIYTGGTTGMPKGVVWRQEDLFFSGLGGGAPTGRPVGRPEELAERVAAGGEGLAFFPTP
                     PLMHGTSTLTAFIAFNFGQKVVLHRKFMPEEVLRTIEKEKVTAASLVGDAMLRPLVDAL
                     TGPLQGTDLSSLLSVSSSGAILSETVRAQFAELAPHTLLLNNFGSSESGFNGTATADSG
                     PEKGFRLRVNARTTVVDPATLTPVAPGEPGRIAQRGHVPLGYYNDPKKTAETFFETDGE
                     RWVLLGDMATVDEEGVITVLGRGSQCIN"
     CDS_motif       complement(1968..2015)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CFP59_RS39670_0002"
                     /evalue="2.50E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="CFP59_RS39670"
                     /protein_end="401"
                     /protein_start="385"
                     /score="13.5"
                     /tool="antismash"
                     /translation="VPLGYYNDPKKTAETF"
     CDS_motif       complement(2610..2660)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CFP59_RS39670_0001"
                     /evalue="6.70E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="CFP59_RS39670"
                     /protein_end="187"
                     /protein_start="170"
                     /score="18.8"
                     /tool="antismash"
                     /translation="FIIYTGGTTGMPKGVVW"
     gene            3336..4142
                     /locus_tag="CFP59_RS39675"
                     /old_locus_tag="CFP59_07847"
     CDS             3336..4142
                     /NRPS_PKS="Domain: ECH (14-260). E-value: 3.5e-50. Score:
                     162.5. Matches aSDomain:
                     nrpspksdomains_CFP59_RS39675_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173688.1"
                     /locus_tag="CFP59_RS39675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07847"
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_069871380.1"
                     /transl_table=11
                     /translation="MTSGTEHLIVERVGATLVLTLNRPEARNALSLPMLVGLYDGWTEA
                     DEDDTVRSVVLTGAGGAFCAGMDLKALAGGGRMAGEHVRDRLAADPDLHWKAMLRHHRP
                     RKPVIAAVEGPCVAGGTEILQGTDIRVAGRGATFGLFEVRRGLFPIGGSTVRLTRQLPR
                     THALEMLLTGRPYPAEEAARIGLIGHVVPDGTALEKALEIAELINANGPLAVEAVKASV
                     YETAEMTETDGLKSELERGWPIFDTADAKEGSKAFAEKRPPVYRRA"
     aSDomain        3378..4115
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CFP59_RS39675_ECH.1"
                     /evalue="3.50E-50"
                     /label="CFP59_RS39675_ECH.1"
                     /locus_tag="CFP59_RS39675"
                     /protein_end="260"
                     /protein_start="14"
                     /score="162.5"
                     /tool="antismash"
                     /translation="ATLVLTLNRPEARNALSLPMLVGLYDGWTEADEDDTVRSVVLTGA
                     GGAFCAGMDLKALAGGGRMAGEHVRDRLAADPDLHWKAMLRHHRPRKPVIAAVEGPCVA
                     GGTEILQGTDIRVAGRGATFGLFEVRRGLFPIGGSTVRLTRQLPRTHALEMLLTGRPYP
                     AEEAARIGLIGHVVPDGTALEKALEIAELINANGPLAVEAVKASVYETAEMTETDGLKS
                     ELERGWPIFDTADAKEGSKAFAEK"
     gene            4204..5163
                     /locus_tag="CFP59_RS39680"
                     /old_locus_tag="CFP59_07848"
     CDS             4204..5163
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058750.1"
                     /locus_tag="CFP59_RS39680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07848"
                     /product="OB-fold nucleic acid binding domain-containing
                     protein"
                     /protein_id="WP_069871383.1"
                     /transl_table=11
                     /translation="MTPAPSPEALQAPLVVEFPFTRSLGPVQSAFLTGLRERTVLGVRT
                     TDGRVLMPPVEYDPVTADELSDLVEVAPTGTVTTWAWNPSPRRGQPLPTPFAWVLVRLD
                     GADTALLHALDAPGPDAVRTGMRVRIRWAGERVGAITDIACFEPYDGAGGGRAVPHRGE
                     FTDPVDGIVAPARLDYTYAPGRAQSRYLKALAGRTIYGERCPSCRKVYVPPRGACPTCG
                     VATDEQVEVGPRGTVTTFCIVNIKARNLDIEVPYVYAHIALDGADLALHARIGDIPYDE
                     VRMGLRVEPVWSEDGRYPDHYRPTGEPDADYDTYKELL"
     gene            5164..6231
                     /locus_tag="CFP59_RS39685"
                     /old_locus_tag="CFP59_07849"
     CDS             5164..6231
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058749.1"
                     /locus_tag="CFP59_RS39685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07849"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_079256561.1"
                     /transl_table=11
                     /translation="MREVAIVAFGQSDHRRDTAEISEVEMLMPVLHQVLDAVGLRAGEI
                     DFTCSGSCDYLAGRAFSFTMTLDGVGAWPPISESHVEMDGAWALYEAWTRLLTGEAETA
                     LVYSYGKSSPGDPREVLTRQLDPYYVAPLWPDSVSLAALQAQALLDAEDTGADERALAG
                     VAARSRTAAEGNPHAQLTGSPPPEALLEDPYVVRPLRRHDCPPVGDGAAAVVLAAGDTA
                     RRLCRRPAWIRGIDHRTEAHSLGVRDLTRSPSTRLAAERAGAFEAPVDLAELHAPFTSQ
                     ELILRRELRLGEGVRVNPSGGALAANPLMAAGLIRLGEAAAAIHRGAADRTLAHATSGP
                     CLQQNLVAVLEGDDT"
     gene            6228..7394
                     /locus_tag="CFP59_RS39690"
                     /old_locus_tag="CFP59_07850"
     CDS             6228..7394
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126125.1"
                     /locus_tag="CFP59_RS39690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07850"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_093699878.1"
                     /transl_table=11
                     /translation="MTKEPVAVVGIGQTKHTAARRDVSIAGLVREAAVRALDDAQLSWA
                     DIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVASGLIAAR
                     VHRTVLTLAFEKQSESNAMWGLSLPIPFQQPLLAGAGGFFAPHVRAYMRRTGAPPGIGA
                     LVAYKDRRNALRNPYAHLHEHDLTLERVRSSPMLWDPIRYSETCPSSDGACAMVLTDRA
                     GADRAPYPPAWMHGGAMRSEPTLFAGKDFVSPRAGRDCAADVYRQAGITDPRREIDAVE
                     MYVPFSWYEPMWLENLGFADEGAGWKLTESGVTEIDGELPVNPSGGVLSTNPIGASGML
                     RFAEAALQVRGRAGEHQVDGARKALGHAYGGGSQFFSMWVVADTPPES"
     gene            7488..7733
                     /locus_tag="CFP59_RS39695"
                     /old_locus_tag="CFP59_07851"
     CDS             7488..7733
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987990.1"
                     /locus_tag="CFP59_RS39695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07851"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_069871390.1"
                     /transl_table=11
                     /translation="MADTTTTEQPLTGSGEKPELDLSGAQWRSSSQGVGDVEIAFVEGF
                     IAMRHGRRPEDPALIFTPGEWRAFVLGAREGEFDLT"
     misc_feature    complement(8018..8033)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.23"
                     /tool="antismash"
     misc_feature    complement(8039..8051)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.5"
                     /tool="antismash"
     gene            8181..10013
                     /locus_tag="CFP59_RS39700"
                     /old_locus_tag="CFP59_07852"
     CDS             8181..10013
                     /NRPS_PKS="Domain: AMP-binding (25-478). E-value: 2.1e-88.
                     Score: 288.6. Matches aSDomain:
                     nrpspksdomains_CFP59_RS39700_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058746.1"
                     /locus_tag="CFP59_RS39700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07852"
                     /product="AMP-dependent synthetase/ligase"
                     /protein_id="WP_100808093.1"
                     /sec_met_domain="AMP-binding (E-value: 2.1e-84, bitscore:
                     282.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREFSLPRMVETLRAGGLADSVYELADREPDRIQFARRHATEPGR
                     WTPVTAAAFRDEVLALAKGLLAEGVRFGDRVALMARTRYEWTLFSYALWSVGAQVVTVY
                     PTSSPEQVRWILAQTRAVAVVVEGEDDAMTVGAVCDALPGLRSIWQMDQGCVTELWQRG
                     TGVHDELVVERRWLVEPRSTAVICYTSGTTGQPLGCMITHANLAAECDTLFAGWNGLFA
                     EPGVQPAILAFLPLAHIYGLMVQVLCVRGGILMGHEPELSPSTLLPSLQSFRPTCVFAV
                     PYIFERILGAARNSAQDDGKRGVFEKAMDTAVRYATALEKQAQGAGKGPGPGLRAAHAV
                     FDHMVYRRIRAVLGGRVRYAVTGGSPFSRELGLAFAGAGITVYNGYGLTETTAAITAQP
                     PGRPRQGTVGRPMPGTAVRIAPDGEVWVRGGTVFAGYVDEPAATGAALRDGWLRTGDIG
                     FLDGDGYLTITGRKKDIIITSGGKSVSPQPLEERLRAHPLISQCVLVGDNRPYVGALIT
                     LDAEMLRRWHQAVGARLPVGREHAAANKALHEEIQQAVSAANRSVSRAESIRAFRILPK
                     EFTVADGLLTPSLKLRRDAVYKVCAAQIEQLYAS"
     misc_feature    complement(8189..8207)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.39"
                     /tool="antismash"
     aSDomain        8256..9614
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CFP59_RS39700_AMP-binding.1"
                     /evalue="2.10E-88"
                     /label="CFP59_RS39700_AMP-binding.1"
                     /locus_tag="CFP59_RS39700"
                     /protein_end="478"
                     /protein_start="25"
                     /score="288.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ADREPDRIQFARRHATEPGRWTPVTAAAFRDEVLALAKGLLAEGV
                     RFGDRVALMARTRYEWTLFSYALWSVGAQVVTVYPTSSPEQVRWILAQTRAVAVVVEGE
                     DDAMTVGAVCDALPGLRSIWQMDQGCVTELWQRGTGVHDELVVERRWLVEPRSTAVICY
                     TSGTTGQPLGCMITHANLAAECDTLFAGWNGLFAEPGVQPAILAFLPLAHIYGLMVQVL
                     CVRGGILMGHEPELSPSTLLPSLQSFRPTCVFAVPYIFERILGAARNSAQDDGKRGVFE
                     KAMDTAVRYATALEKQAQGAGKGPGPGLRAAHAVFDHMVYRRIRAVLGGRVRYAVTGGS
                     PFSRELGLAFAGAGITVYNGYGLTETTAAITAQPPGRPRQGTVGRPMPGTAVRIAPDGE
                     VWVRGGTVFAGYVDEPAATGAALRDGWLRTGDIGFLDGDGYLTITGRKKDIIIT"
     CDS_motif       8730..8789
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CFP59_RS39700_0001"
                     /evalue="3.50E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="CFP59_RS39700"
                     /protein_end="203"
                     /protein_start="183"
                     /score="22.7"
                     /tool="antismash"
                     /translation="AVICYTSGTTGQPLGCMITH"
     CDS_motif       9447..9515
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CFP59_RS39700_0002"
                     /evalue="5.20E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="CFP59_RS39700"
                     /protein_end="445"
                     /protein_start="422"
                     /score="12.5"
                     /tool="antismash"
                     /translation="GEVWVRGGTVFAGYVDEPAATGA"
     gene            complement(10001..11191)
                     /locus_tag="CFP59_RS39705"
                     /old_locus_tag="CFP59_07853"
     CDS             complement(10001..11191)
                     /EC_number="4.2.3.157"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058745.1"
                     /locus_tag="CFP59_RS39705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07853"
                     /product="isoafricanol synthase"
                     /protein_id="WP_100808094.1"
                     /sec_met_domain="T1TS (E-value: 1.5e-72, bitscore: 244.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTHASRPHARQSALPRRADLFDFPASADLSPDTGAARQHTIQWL
                     SRFRVFENHASVEEYDALRFDVLTGLFYPRATGADLNLGSDLVGWYFVFDDQFDGELGC
                     RPEEVARLVADVIRVTEEDMAPGGTGGGEGPLLESFRDLWRRINSGRPRVWRDRFRHHW
                     LEYLHSYHREALERTGAPPADGGGDAPRSVEDVLALRRHSIGVQPCLDLNEPFGGYTLP
                     SALHGGFPLARMREATDDVVVFTNDIASLDKELAVGDVHNSVIVQWKLAGGGVEDAVRH
                     IAGLANARYGWFEETAARLPELLAEAGADPGTHRAVGRYVDGMRHVMTGNLGWSLRTAR
                     YDERGTEAVSGGRQRPWARLTGAEDLIRAGRGAPPPPPGSGPDTRQPMPSEPSQLA"
     gene            11444..14371
                     /locus_tag="CFP59_RS39710"
                     /old_locus_tag="CFP59_07854"
     CDS             11444..14371
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058744.1"
                     /locus_tag="CFP59_RS39710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07854"
                     /product="AAA family ATPase"
                     /protein_id="WP_100809504.1"
                     /transl_table=11
                     /translation="MSQQNRTHRTLLERERELRAVDGALTELCGTEPADRDEIRGGGVI
                     AFEGPGGVGKTALLGEARRRAVARGCTVLRARGGEHEQGAAFHVVRQLFQPVLAATGED
                     EHRRILGGWYDIVAPAVGLVVSGSGGAPDPQGVRDGLDWLVTRFTVEHAPVVMILDDVH
                     WADPESLDWLTRFASRTADLPLLLAVGYRPEDLTADVAAIRALVERQGARPHVLAPLTP
                     GGVGRIVREVLGGHADEAFCRECWAMTGGNPWEITELTAKIRDRRLKPQSENLPALREL
                     VSSARDSGLNDRLTRLGTAAVRLAWAVAVLGIEATPALTANVAGLSESEAAEKVARLVD
                     ARILAPPRPGNGTQPLEYLHPLIATAVYQAIPGAMRVAMHGQAATVVLGAGLGSAAAGR
                     HLLEMHPEGDPWVVHHLREAAREYLRAGAPDAGRRCLARALREPPALEERAAVLYELGC
                     AAQLTEPDVTVNHLRAALGEPALGPELREAITYRLAQAYGHSGRMEEAAQVFADEVGRA
                     TSARTRLRMQTEQLMWNMFRADEKESPARSRRLTRLAEHLTGRGMAERYLMGLRAWDAM
                     TRGEPIATALHYAEEALGDGLSWTDDDWGFEVPILVALVFLHCDQPGRAEELFNKGIAE
                     CERKGWRGSHLAFGFTLLGYARLRRGALGEAEELAREGMRIADLVGSSTPAHWTAVGTL
                     IGTLICRGRIQEAQEFAAGHRGETLPQATLCPDVPAVRGELLLAANLHREARNRLTEVG
                     RRMDGRGMRNPAWCPWQLHLAQALALTDPRQAAEVADDAVRRARQFGAHSAIGKALHTA
                     ATVTQGPDRIKLLAEAVSHLMRSPAAYDLALALVDHGAALRRIGLPQEAGDRLYRGLEG
                     AVRCGADALAARARDELSAAGLRPMQLRVDHTSPLTSQEQAIAERAAEGWPDARISETT
                     GLEEREVARLLSDVYRKVGTDRAGLAKRLITPTVGLPQRPVPDPE"
     gene            14433..14933
                     /locus_tag="CFP59_RS39715"
                     /old_locus_tag="CFP59_07855"
     CDS             14433..14933
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058743.1"
                     /locus_tag="CFP59_RS39715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07855"
                     /product="hypothetical protein"
                     /protein_id="WP_020873536.1"
                     /transl_table=11
                     /translation="MSFLRRRSAATPTGPDFDVLAMDPGDWPGDLGAGLLPAPDGTCQG
                     VFLRYDLFGGRGPAMIIGNLPEGSPAREVAEGQPPFEVTQLLAALGNDEPVQVVDTEDS
                     PVMHEDNLLIVRRIKLSEGRISCAQFDRSDGVLVTIASWDRPITDDLYRLLKPLPAEMF
                     QQR"
     gene            complement(15078..17111)
                     /locus_tag="CFP59_RS39720"
                     /old_locus_tag="CFP59_07856"
     CDS             complement(15078..17111)
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058742.1"
                     /locus_tag="CFP59_RS39720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07856"
                     /product="peptidoglycan recognition family protein"
                     /protein_id="WP_100808095.1"
                     /transl_table=11
                     /translation="MPESAQDSAHDANRDPSGPTRRTTLRTAGAVASAAFLLPLVAATP
                     AAHADQSRAEGAEGPPADGGALQRAFAAAAAEYGVPLSVLLGVSYLQSRWDGHRGAPSV
                     TGGYGPMHLTDAHTALLGAPHHSQGTEDARGDLARPLRVPKATVPEPRRLPARLRTLGR
                     AAELTGLSAEALRGDESANVRGGAALLAAAQKRLGLPRSEDPADWYAAVAAYSGADDAT
                     AAGVFADEVYSVIRGGASRTTADGERVSLDAAPAVAPDTRQLRTLGLASPARDPRVEAP
                     KDVSCEWLPAPYEEFGDNDYGNHDLGERPSSQSIDYIVIHDTEGSWDTTLKLVQDPTYV
                     SWQYTLRSSDGHIAQHVPLKDVAWHAGNWYVNAKSIGLEHEGFLTAPDAWYTEAMYRSS
                     ARLVRYLAKRFDIPLDRQHILGHDNVPGTTTGTIPGMHTDPGPYWDWAHYFTLLGAPFQ
                     RTAGSSGGLVTIRPDYDTNRPVYTDCETAGQACAPHGSAAVRLHTAPSADAPLVKDIGL
                     RPDGSDSTTGVNDTGARATTGQQFAVAGHEGDWTAIWYLGQRAWFQNPKRRPTAVSAKG
                     LVVTPKGGAAEVAVYGRAYPEKEAYPEGVPVQAVSPLPYKLLAGQSYPLGLRTRGEYLW
                     ATTFDPAGHKVVRGQDVYYQIQFGHRVAFVRAADVTVRRSGK"
     misc_feature    complement(17232..17247)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.0"
                     /tool="antismash"
     gene            complement(17277..18380)
                     /locus_tag="CFP59_RS39725"
                     /old_locus_tag="CFP59_07857"
     CDS             complement(17277..18380)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474392.1"
                     /locus_tag="CFP59_RS39725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07857"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_093699875.1"
                     /sec_met_domain="APH (E-value: 7.3e-21, bitscore: 74.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYAASSSVSAPPRPYRRQLPGTGPYLDPAPGGRTRRTAALGPVPP
                     RGRLDLSGPQGAQLRTAITSVHRICPEFNPVQVLRRSGRSVLLIGATGRSTAVAKCLLD
                     HSPAWAERFRREIAMYRAFVRQRPPVRVPRLIAADPDNCALVIERMPGRIAAAQRHPTE
                     PPPRADLGAVLGAIRRVNQWRPPAGLFDAPIDYAVRLTRYHELGLLTDRDMGDLQKLLR
                     GVSQTCGRQTPAQFSHGDALLNNVLLSPAGPVLLDWDHAGWYLPGYDLATLWTVLGDAP
                     VTRRQISQLAQAAGPATRDSFLVNLMLVLTREIRQYETAVQRTMHDPAPVVPGAVPAGE
                     EQRLLLRRLHDDCALARRAVRAAVGTR"
     gene            18627..20135
                     /locus_tag="CFP59_RS39730"
                     /old_locus_tag="CFP59_07858"
     CDS             18627..20135
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058740.1"
                     /locus_tag="CFP59_RS39730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_07858"
                     /product="hypothetical protein"
                     /protein_id="WP_079256555.1"
                     /transl_table=11
                     /translation="MTREPNTRLADLFGLAGWSKGELARLVNRKAAAMGHPQLATDTSR
                     VRRWIDTGETPRDPVPKVLAALFTERLGRVVTIEDLGFGRGGRAGKGQSGDGLFWPPES
                     TAAVLTEFTGMDLMFNRRGLVGAGAALAAGSAITGAMSDFLLSDPTLATDAPRTDNPLS
                     VEPVGFDRYEAAPVGSQEIDALEGSVEVFRAWDAARGGGLQRKAVVGQLNEVGGMLAYR
                     HPEHLQRRLWGVAANLAVLAGWMSHDVGLEPTAQKYFVIAAHAAREGDDRPRAGEALSR
                     AARQMVHLGRPDDALDLMKLATSGAGEQALPCTRAMFRTIEAWAQASKGHGQAARRALG
                     EAEELFVSDGDHGPAPSWMQLFNEADLHGMQGLVYRTLAEHEPAAAGIALNHAKKALRM
                     REGGRQRSQIFDHISIASACFIGDDPEQAERYARTALLTIEQNSSHRTWDRLREMYRLT
                     ARYGTSPAVRELREEIQRALPKGGAGKGGAGLKGSGSIARSAAV"
ORIGIN
        1 ccggcagtga gggtgcgttc gcccatgtga cgcggtcgcg ctgggcacgt cgggcgccat
       61 cctgatccgg ccatcgcgcc cggggccggt tccgcttccc gcgggaccgg ccccgtggcg
      121 tgctcgcggt gcggcgacct atcgttccag agcccaccgg gccgcccgga cgaccttacg
      181 ggcccgcccg caacaccggg acgggcccgc ccgtaccgcc gggactggcc cgcccgcgac
      241 accgagacgg gctcgcccgt accgccgaga gaggaatccc cgctcatgcg accgcatctg
      301 tccccgcgcc atgcgctgat cgccgcactc gccaccgccg tgctggccac cggggccacc
      361 gccgccgtcg ccgcaccggc aggtccggcc ggtccggccc gtgcccacgg cactctgcgg
      421 ccgctggtcg aactggccgc gcagcgggtg ctggtggccg acgaggtcgc cgccgcgaag
      481 tgggccacgg acagcccgat cgacgatccg gcgcgggagc gggaggtgct ggacgcggtg
      541 gcgcggcagg ccgaggagct gggcgccgac cccgcggcga cgacgaggat cttccgcgac
      601 cagatcgagg ccagcaaggt cgtccagcgc ggcctctacc accgctggga cgccgacccc
      661 tcacaggcgc ccaccgaacg ccccgacctc gggcggatcc ggctggagat caaccggatc
      721 aacggcgaac tcgtgcgcgc catcgcggac tcggcggccg tgcgcgaggg cccctcctgc
      781 gtggggcggc tcacggccgg gacggtcgcc gtggtccacg ggcgccacct ggacgtgctg
      841 cacacggtgg cgctcggccg ctcgctgccg tcggtgtgcg agcgctgagc gccgtcaagc
      901 cgtgaagggg gcgggtcaga ccgcggggcg gtcgtggagg acgcgctgga agagcagatg
      961 gtcccgccag gcgccggcga tgtgcagata gtccggcgcc atgccgatcc gggtgaatcc
     1021 gcagcggagc agaacgcctt gggacgggac gttctccacc agcgtgctgg cctcgatccg
     1081 gtgcagtccg aggcgctcgt cggccacccg gcacacggac cggacggcca gggaggccag
     1141 cccgcgcccg aggtgcccgg cgtcgatcca gtagccgaga tggccgttgc gccagggccc
     1201 gaggacgata tgcgacagcg tgaccgtgcc caggatccgc tcgccgccgg tcagcaccca
     1261 gggcaccatc cggccggact cccactgctc cagctggtcc cgcagccggg cggcctggcc
     1321 gtcggcggtg aagaagctct cgtcccgccg cgggctggac ggacgcagat gctcacggtt
     1381 gcgcgtgtac gcgtccgcga gcgcctcggc gtcgtcctcg acggcggttc gcatggtgat
     1441 cccgtcggcc agggtcacag agggaagggg caccgccgcg gcaggaagag tcacctggtc
     1501 agcctagtcg gcgcggcggg tcagccgggg tgcggggcgc cccggtcctg gtgcggggtc
     1561 tccccgtccg tcccctgggc gaccgcccgc gcccagcggt agtcggcctt gccgctggga
     1621 gagcgctgga tgtggtcggt gaagacgacc gtacgaggga tcttgtagcc cgcgagccgc
     1681 tcccggcagt ggtcgcggac cgcctcggcg gtgagcccgg acgccggggt ccggggctgg
     1741 acgacggccg ccacgcgatg gccccatcgg gtgtcgggga cgcccgccac cagcgcgtcg
     1801 tacacctccg gatgggcctt cagggcctgc tcgacctcct ccgggtagac cttctcgccc
     1861 ccggtgttga tgcactgcga accgcgcccg aggacggtga tcacaccctc ctcgtccacg
     1921 gtcgccatgt cgccgagcag cacccagcgc tccccgtccg tctcgaagaa cgtctcggcg
     1981 gtcttcttcg gatcgttgta gtagccgagc ggcacatggc cgcgctgggc gatccggccg
     2041 ggctcaccgg gcgccaccgg ggtgagggtc gccgggtcca ccaccgtcgt acgggcgttg
     2101 acgcgcagcc ggaagccctt ctcgggaccg gagtcggcgg tggccgtgcc gttgaaaccg
     2161 gactccgagg agccgaagtt gttgagcagc agggtgtgcg gggcgagctc ggcgaactgg
     2221 gcgcgtacgg tctccgacag gatcgcgccc gagctgctga cgctgagcag cgaggagaga
     2281 tcggtgcctt ggaggggtcc ggtcagggcg tccaccaggg gccgcagcat cgcgtcgccg
     2341 accagcgagg cggcggtgac cttctccttc tcgatggtcc gcagcacctc ctcgggcatg
     2401 aactttcggt gcagcaccac cttctgaccg aagttgaacg cgatgaaggc cgtaagggtg
     2461 gaggtgccgt gcatcagcgg cggggtgggg aagaaggcca gcccctcgcc gcccgcggcc
     2521 acccgctcgg ccagctcctc cgggcgcccg acgggccggc cggtcggggc gccgccgccg
     2581 agccccgaga agaacaggtc ctcctgccgc cacaccacgc ccttgggcat accggtggtg
     2641 ccgccggtgt agatgatgaa gcggtcgtcg gcggagcgcg ccgggaagcc gcgctcgggc
     2701 gacccggacg cctcggcgtc gccgaacgcc acggacgcac gggggccgtg cccggtgccg
     2761 acccgcacca gatggcgcag ggtgccggtg tggggcagcg cggcggccac ccgctcgccg
     2821 aactcggcgt cgtagaccag cgcggccagg tccgcgtcgc ggtagaggta gaccaactca
     2881 tcttcgacgt agcggtagtt gacgttcacc ggcaccgccc ggatcttcag acaggccagc
     2941 gcggtctgga ggtactcgac gccgttgcac agatgcagtc cgacgtgctc gcccggggcg
     3001 atcccgctgt cgccgagatg gtgggcgagc cggttggcgg ccgcgtcgag ctgggcgtag
     3061 ctcagacgcc gctcggcccc ggtgccgggg tggtcgatgt acaccagcgc ctctctgtcg
     3121 ggcaccgtgt cgacgatcga ctcgaacagg tcggcaaggt tgtactccac ggctcctcct
     3181 gacccctcga tccggcggct cggcgctcat tagagccgcg ccgggatgag gtgggaaggc
     3241 ccgcggaaca agaaatctga ctgagcatca gatttctctt gaagtcggcc tgcggctgct
     3301 gcaacctgtt ctaggtctcg agacgggagg acgtcgtgac aagcgggacc gaacacctca
     3361 tcgtcgagcg cgtcggcgcg accctggtgc tcaccttgaa tcggcccgag gccaggaacg
     3421 cgctctcgct gccgatgctg gtcgggctgt acgacggctg gaccgaggcc gacgaggacg
     3481 acaccgtgcg ctccgtggtg ctcacgggcg ccggtggggc cttctgcgcc ggaatggacc
     3541 tcaaggcgct cgcgggcggc ggccggatgg ccggcgagca tgtccgcgac cgcctcgcgg
     3601 ccgaccccga tctgcactgg aaggcgatgc tccgccacca ccggccgcgc aagccggtga
     3661 tcgccgccgt cgagggcccc tgcgtcgcgg gcggcaccga gatcctccag ggcaccgata
     3721 tccgggtcgc gggccgcggc gccaccttcg ggctcttcga ggtccggcgc gggctgttcc
     3781 ccatcggcgg ctccaccgta cggctgaccc gccagctgcc ccgcacccac gccctggaga
     3841 tgctgctgac ggggcgcccc tacccggccg aggaggcggc acggatcggg ctcatcggcc
     3901 atgtcgtccc ggacggcacg gcgctggaga aggccctgga gatcgcggag ctgatcaacg
     3961 ccaacggccc gctcgccgtc gaggcggtca aggcgtccgt ctacgagacc gccgagatga
     4021 ccgagaccga cggcctgaag tccgaactcg aacgcggctg gcccatcttc gacaccgccg
     4081 atgccaagga gggctcgaaa gccttcgcgg agaaacggcc gccggtctac cgccgggcgt
     4141 gatcccccac cacctcaggc cggcgccccc acccggcggc cgcgcggaag gagacgcacc
     4201 cccatgaccc cggctccctc gcccgaggcg ctccaggcgc ctctggtcgt cgagttcccg
     4261 ttcacccgct ccctcggccc ggtgcagagc gccttcctca ccgggctgcg cgaacgcacc
     4321 gtgctcggcg tgcgcaccac cgacggccgg gtgctgatgc cgcccgtcga atacgacccg
     4381 gtcaccgccg acgaactgtc cgacctcgtc gaagtcgccc ccaccggcac cgtcaccacc
     4441 tgggcctgga acccctcccc gcgccgcggc cagcccctgc ccaccccctt cgcctgggtg
     4501 ctggtgcggc tggacggcgc ggacaccgca ctcctccacg ctctcgacgc gcccggcccc
     4561 gacgcggtgc gcaccggtat gcgggtgcgg atccgctggg ccggggagcg cgtcggcgcc
     4621 atcaccgaca tcgcctgctt cgagccgtac gacggcgccg ggggcggccg agccgtgccg
     4681 cacaggggcg agttcaccga ccccgtcgac ggcatcgtgg cccccgcccg cctcgactac
     4741 acctacgcgc ccggccgcgc ccagtcgcgc tatctgaagg ccctcgccgg ccgcaccatc
     4801 tacggggagc gctgcccgtc ctgccgcaag gtgtacgtcc cgccccgggg cgcctgcccc
     4861 acctgcggcg tggccaccga cgaacaggtg gaggtcggcc cgcgcggcac ggtcaccacc
     4921 ttctgcatcg tcaacatcaa ggcccgcaac ctcgatatcg aagtgccgta cgtctacgcc
     4981 cacatcgccc tggacggcgc cgatctggcc ctccacgcac gcatcggcga catcccctac
     5041 gacgaggtgc ggatggggct gcgcgtggag cccgtatgga gcgaggacgg ccgctacccc
     5101 gaccactacc ggcccaccgg cgaacccgac gccgactacg acacctataa ggagctgttg
     5161 tagatgcgag aggttgccat cgtcgccttc ggccagagcg accaccggcg cgacaccgcg
     5221 gagatctccg aggtcgagat gttgatgccc gtcctccacc aggtgctcga cgccgtcgga
     5281 ctccgggccg gcgagatcga cttcacctgc tccggctcct gcgactatct ggcgggccgc
     5341 gccttctcct tcaccatgac cctcgacggc gtcggcgcct ggccgcccat ctcggagtcc
     5401 catgtggaga tggacggcgc ctgggcgctg tacgaggcat ggacgaggct gctgaccggc
     5461 gaggcggaga ccgcgctcgt ctactcctac ggcaagtcct cacccggcga tccgcgcgag
     5521 gtcctcactc gccagctcga cccgtactac gtggcgcccc tgtggccgga ctcggtctcc
     5581 ctggccgccc tccaggccca ggcgctgctg gacgcggagg acaccggtgc cgacgagcgg
     5641 gcactggccg gggtggcggc gcgcagccgg accgcggccg agggcaaccc gcatgcccag
     5701 ctgaccggtt caccgccgcc cgaggccctc ctggaggacc cgtatgtggt gcggccgctg
     5761 cgccgccacg actgcccgcc ggtcggcgac ggcgcggccg ccgtcgtgct cgccgccggg
     5821 gacaccgcgc gccggctctg ccgccgcccc gcctggatcc gcggtatcga tcaccggacg
     5881 gaggcccaca gcctcggtgt acgggacctc acccgctccc cgtccacccg gctcgccgcc
     5941 gagcgcgcgg gcgccttcga ggcccccgtg gacctggccg agctgcacgc cccgttcacc
     6001 tcacaggagc tgatcctccg ccgtgagctg cggctggggg agggcgtacg ggtcaatccg
     6061 tccggcgggg cgctggccgc caaccccctg atggccgccg ggctgatccg cctcggcgag
     6121 gccgccgccg ccatccaccg cggcgccgcg gaccggaccc tcgcccatgc cacctcgggc
     6181 ccttgtctcc agcagaacct ggtggccgtc ctggaagggg atgacacgtg acgaaggagc
     6241 cggtggccgt cgtcgggatc ggccagacca agcacaccgc cgcacgccgg gacgtctcca
     6301 tcgccgggct ggtccgggag gccgccgtac gggccctgga cgacgcccag ctgagctggg
     6361 cggacatcga cgccgtcgtg atcggcaagg cccccgactt cttcgagggc gtcatgatgc
     6421 ccgagctgta cctcgccgac gcgctcggcg ccgtcggcaa gccgatgctg cgcgtgcaca
     6481 ccgccggctc ggtcggcggc tccaccgcgc tggtggcctc ggggctgatc gccgcccggg
     6541 tccaccggac cgtcctcacc ctcgccttcg agaagcagtc ggagtcgaac gccatgtggg
     6601 ggctttccct gcccatcccc ttccagcagc cgctgctggc cggggcgggc ggcttcttcg
     6661 caccacacgt acgggcgtat atgcggcgca ccggcgcgcc ccccggtatc ggcgcgctcg
     6721 tggcctacaa ggaccgccgc aacgccctgc gcaaccccta cgcccacctc cacgagcacg
     6781 atctgaccct ggaacgggtg cggtcctccc cgatgctgtg ggaccccatc cgctactccg
     6841 agacctgccc ctcctcggac ggcgcctgcg ccatggtgct caccgaccgc gccggcgccg
     6901 accgcgcgcc gtatccgccc gcctggatgc acggcggcgc catgcgcagc gagccgacgc
     6961 tcttcgcggg gaaggacttc gtctcgccgc gggccggccg ggactgcgcg gccgatgtct
     7021 accgccaggc agggatcacc gacccgcgcc gggagatcga cgcggtggag atgtatgtgc
     7081 ccttcagctg gtacgaaccc atgtggctgg agaacctggg cttcgcggac gagggggcgg
     7141 gctggaagct caccgagtcg ggggtgaccg agatcgacgg cgagctcccg gtcaacccgt
     7201 ccggcggggt gctgtccacc aacccgatcg gggcgtccgg aatgctgcgg ttcgccgagg
     7261 ccgcgctcca ggtgcgcggg cgggcgggcg aacaccaggt cgacggcgcc cgtaaggcgc
     7321 tcggtcacgc ctatggcggc ggctcgcagt tcttctcgat gtgggtggtc gcggacactc
     7381 cgccggagag ctgagtctcc tgctcactcc tcctttcgtg gcctgtgcgg caccggccgc
     7441 gatcgctagg gtggggcgcg gacgacgatc cgggaggatg agccgacgtg gccgatacca
     7501 ccaccaccga acagccactg acaggaagcg gggagaagcc cgaactcgac ctctcgggcg
     7561 cccaatggcg gtcgagcagc cagggcgtgg gcgatgtgga gatcgccttt gtcgagggat
     7621 tcatcgcgat gcgccacggc cgccgtcccg aagacccggc gctgatcttc accccgggtg
     7681 agtggcgcgc cttcgtcctg ggcgcgcgtg agggcgagtt cgacctcacc tgaaccgggg
     7741 ctccaccggg ggcgggcggg tccggccgga ccggacggcc cgccccgtgg catgtcgtcc
     7801 ctcatccgtg gcatatcgcc cctcactcat ggcatgtcgc gccgtcaaaa gggcccgtcg
     7861 gcggccccgc ggtgcctgac ccatggcgat gagtgcgtta tcggccagaa tcggagcgcg
     7921 gcggaccgcg gtggagccac acatcgccgg gagcggccac gagatccgtc ttcccatggc
     7981 ttcgcggcag ggtcacgaaa cctccatgcc ttctgccgaa acgtgagcgt gactcacggt
     8041 gacagcggca ggtcgcgacg ggtctccacg atggggaaca ggatcgtccg cgctctatgc
     8101 agccctcgcc tcgagaggta gttttccctc ccacctcccc gttgtacggg gcggcaactc
     8161 ggctgaaaac agggggtgtc gtgcgcgaat tcagtctccc tcgcatggtg gaaactctgc
     8221 gcgcgggcgg actggcggac tcggtgtacg agctggcgga ccgcgaaccg gaccggatcc
     8281 agttcgcccg gcgccacgcc accgaacccg gccggtggac tccggtgacc gccgcggcct
     8341 tccgggacga ggttctggcg ctggcgaagg gcctgctggc cgagggtgtg cgattcggtg
     8401 accgggtggc cctgatggca cggacgcggt acgagtggac gctgttcagc tatgccctgt
     8461 ggtccgtcgg cgcccaggtg gtgaccgtct accccacctc ctcgccggag caggtgcgct
     8521 ggatcctggc ccagacgcgg gccgtggccg tggtggtcga gggcgaggac gacgccatga
     8581 cggtcggcgc cgtctgcgac gcccttcccg ggctgcgctc catctggcag atggaccagg
     8641 ggtgcgtgac ggagctgtgg cagcgcggca ccggcgtcca cgacgaactg gtcgtcgagc
     8701 ggcgctggct cgtggaaccg cgctccacgg cggtcatctg ctacacctcg ggcaccaccg
     8761 gacagcccct cgggtgcatg atcacccatg ccaacctcgc cgccgaatgc gacaccctct
     8821 tcgcgggctg gaacgggctg ttcgccgagc ccggggtgca gcccgccatc ctcgccttcc
     8881 tcccgctggc ccacatctac ggactgatgg tccaggtgct ctgcgtacgg ggcggcatcc
     8941 tcatgggaca cgagcccgag ctctccccgt cgactctgct gccgtccctc cagtccttcc
     9001 gcccgacctg tgtcttcgcg gtgccctaca tcttcgagcg gatcctcggg gccgcgcgga
     9061 actccgccca ggacgatggc aagcgcgggg tcttcgagaa ggccatggac acggcggtgc
     9121 gctacgccac ggcgctggag aagcaggcac agggcgccgg gaagggaccg ggccccggcc
     9181 tcagagccgc gcacgccgtc ttcgaccaca tggtctaccg gcgcatcaga gccgttctgg
     9241 gcggccgggt gcgctacgcg gtcaccggcg gctccccgtt cagccgggag ctggggctgg
     9301 cgttcgcggg agccgggatc accgtctaca acggctacgg cctcaccgag acgacggcgg
     9361 cgatcaccgc acagccgccc ggccgccccc ggcagggcac ggtgggccgc ccgatgcctg
     9421 gcacggcggt gcgcatcgcg ccggacggcg aggtgtgggt gcgcggcggc accgtcttcg
     9481 cgggctatgt ggacgagccg gcggccaccg gggccgcgct gcgcgacggc tggctgcgca
     9541 ccggagacat cggattcctc gacggcgacg gctatttgac catcaccggc cgtaagaagg
     9601 acatcatcat caccagcggc ggcaagagcg tctcgccgca gccgctcgag gagcggctgc
     9661 gggcgcatcc actgatctcg cagtgcgtcc tggtgggcga caaccgcccc tacgtcgggg
     9721 cgctgatcac cctggacgcc gagatgctga ggcgctggca ccaggcggtc ggcgcgcggc
     9781 tgcccgtcgg ccgggagcac gcggcggcca acaaggcgtt gcacgaggag atccagcagg
     9841 cggtctcggc ggcgaaccgc tcggtgtcca gggcggagtc gatcagggcc ttccgtatcc
     9901 tcccgaagga attcaccgtg gcggacgggc tgttgacgcc ctcgctcaag ctgcggcgcg
     9961 acgcggtcta caaggtctgc gccgcgcaga tcgagcagct ctacgcgagc tgagagggct
    10021 ccgagggcat cggctgacgg gtgtccgggc cgctgccggg cggtggcggc ggagcgcccc
    10081 ttcccgcgcg gatcaggtcc tccgcgccgg tcagccgggc ccacggccgc tgccgtcccc
    10141 cgctgaccgc ctcggtgccc cgctcgtcgt accgggccgt ccgcagcgac cagcccagat
    10201 tgcccgtcat cacatgccgc atgccgtcca catagcgccc caccgcgcgg tgggtgccgg
    10261 gatccgcccc cgcctcggcc agcagctccg gcagcctggc cgcggtctcc tcgaaccagc
    10321 cgtagcgggc gttggcgagg ccggcgatat ggcgtaccgc gtcctccact ccaccgcccg
    10381 cgagcttcca ctggacgatg acgctgttgt ggacgtcgcc gacggccagt tccttgtcca
    10441 gggaggcgat gtcattggtg aagaccacca catcgtccgt ggcctcccgc atccgggcca
    10501 gcgggaagcc gccgtgcagc gcggacggca gggtgtagcc gccgaacggc tcgttcaggt
    10561 ccagacaggg ctgtacgccg atcgagtggc gccgcagggc cagcacgtcc tccaccgagc
    10621 gcggcgcgtc cccgccgccg tccgcgggcg gggcaccggt ccgctccagg gcctcgcggt
    10681 ggtaggagtg cagatactcc agccagtggt ggcggaagcg gtcccgccac acccggggcc
    10741 gcccggagtt gatccggcgc cacagatcgc ggaagctctc caggagcggc ccttcgccgc
    10801 cgcccgtccc gccgggtgcc atgtcctcct cggtgacccg gatgacgtcc gccaccagcc
    10861 gtgccacctc ctccgggcgg cagcccagtt ccccgtcgaa ctggtcgtcg aagacgaagt
    10921 accagcccac gaggtcgctg ccgaggttca gatcggcgcc ggtcgcccgg ggatagaaca
    10981 gtcccgtcag tacgtcgaag cggagcgcgt cgtactcctc gacggacgcg tggttctcga
    11041 agaccctgaa ccgtgagagc cattggatgg tgtgctgcct cgccgccccg gtgtccgggc
    11101 tgaggtcggc ggaggccggg aagtcgaaca ggtccgcccg tcgcggcagc gccgactgcc
    11161 gggcgtgtgg tcgcgaagcg tgcgtgtgca tgagtcgtct ccgccccctt cgtcgtccgg
    11221 gcggcccgag cccgcacata ccacaggcgt atacggcaac tggccaaccc gctgaatccg
    11281 gtcatcctcg cgtgcggaac gtggcatcga tagaggaggc ggtgaattgg cgcatgccag
    11341 tggcaagagc ggacggaaat ccctccatac gggagctacg gagcgtgcca ttcacgctac
    11401 gctcggcgtc acctgccgga ggggaagcaa cgtggcggag tacatgagcc aacagaaccg
    11461 gacgcaccgg acactgctgg aacgggagcg ggagctgcgc gcggtggacg gcgcgctgac
    11521 cgaactgtgc ggaacggaac ccgccgaccg ggacgagatc cgcggcggcg gagtgatcgc
    11581 cttcgagggg cccggcggcg tcggcaagac cgcactgctc ggcgaggcac gccggcgggc
    11641 cgtcgcccgc ggctgcaccg tgctccgcgc ccgtggtggc gagcacgaac agggcgcggc
    11701 cttccacgtg gtgcgccagc tcttccagcc ggtgctcgcg gcgaccggcg aggacgagca
    11761 ccgccgcatc ctcggcggct ggtacgacat cgtggcgccc gcggtcggcc tggtggtctc
    11821 cggcagcggc ggcgcacccg atccacaggg cgtccgcgac ggcctcgact ggctggtgac
    11881 ccgcttcacc gtggagcacg ccccggtcgt catgatcctc gacgatgtcc actgggccga
    11941 ccccgaatcg ctggactggc tgacccggtt cgcctcgcgc accgccgatc tgcccctgct
    12001 gctcgccgtc ggctaccgcc ccgaggacct gaccgccgac gtcgccgcga tacgggccct
    12061 ggtcgagcgc cagggagcac ggccccacgt actggccccg ctcaccccgg gcggcgtcgg
    12121 cagaatcgtc cgggaggtcc tcgggggcca cgccgacgag gcgttctgcc gtgagtgctg
    12181 ggcgatgacc ggcggcaacc cctgggagat caccgagctc accgccaaga tccgcgaccg
    12241 caggctgaaa ccgcagtcgg agaacctgcc cgcactgcgc gaactggtct cctcggccag
    12301 ggacagcggg ctcaacgacc ggctgacccg cctcggcacc gccgccgtcc gcctcgcctg
    12361 ggccgtcgcc gtcctcggta tcgaggccac cccggcgctc accgcgaatg tcgccgggct
    12421 cagcgagtcc gaggccgccg aaaaggtggc gcggctcgtc gacgcgcgga tcctggcccc
    12481 gccgcgcccc ggaaacggca cccaacccct ggagtacctc cacccgctca tcgccaccgc
    12541 cgtctaccag gcgatccccg gcgccatgag agtggccatg cacggccagg ccgccaccgt
    12601 ggtgctcggc gcgggcctgg gttccgcggc ggccggccgg catctgctgg agatgcaccc
    12661 cgagggcgac ccatgggtgg tgcaccatct gcgggaggcc gcccgggagt atctgcgcgc
    12721 cggggcaccc gacgccgggc gccgctgtct ggcccgcgcc ctgcgcgaac cgcccgccct
    12781 ggaggagcgc gccgccgtgc tgtacgagct gggctgcgcc gcccagctca ccgagcccga
    12841 tgtcaccgtc aaccatctgc gggccgccct cggggagccc gcgctcggcc ccgaactgcg
    12901 cgaggcgatc acctaccggc tcgcccaggc gtacggccac agcggccgta tggaggaggc
    12961 cgcccaggtc ttcgccgacg aggtcggacg cgccaccagc gcccgcaccc ggctgcggat
    13021 gcagaccgag cagctgatgt ggaacatgtt ccgcgccgat gagaaggagt cgcccgcccg
    13081 ctcccggcgg ctcacccggc tcgcggagca cctcaccggc cgcggcatgg ccgagcgcta
    13141 tctgatgggg ctgcgcgcct gggacgcgat gacgcgcgga gagcccatcg ccacggcgct
    13201 gcactacgcg gaggaggccc tcggcgacgg cctcagctgg accgatgacg actggggctt
    13261 cgaggtgccc atcctggtcg ccctggtctt cctccactgc gaccagcccg gacgcgccga
    13321 ggagctgttc aacaagggca tcgccgaatg cgagcgcaag ggctggcgcg gctcccacct
    13381 ggcgttcggc ttcaccctcc tcggctatgc ccgactgcgc cgcggcgccc tcggcgaggc
    13441 ggaggagctg gcccgtgagg ggatgcggat cgccgatctg gtgggctcct cgacacccgc
    13501 ccactggacc gcggtcggca ccctcatcgg aacgctgatc tgccgcggcc ggatccagga
    13561 ggcgcaggag ttcgcggccg ggcaccgtgg cgagaccctt ccgcaggcca cgctctgccc
    13621 cgatgtgccg gcggtccgcg gtgagctgct gctcgccgcc aatctgcacc gcgaggcccg
    13681 gaaccggctc accgaggtcg gccgccgcat ggacgggcgc ggtatgcgca accccgcctg
    13741 gtgcccctgg cagctccacc tcgcccaggc cctcgcgctc accgatcccc ggcaggccgc
    13801 cgaggtcgcc gacgacgcgg tgcgccgcgc ccgccagttc ggcgcccact ccgcgatcgg
    13861 caaggcgctg cacaccgcgg ccaccgtgac ccaggggccg gaccggatca agctgctggc
    13921 cgaggccgtc agccatctga tgcgctcacc ggccgcgtac gacctggccc tggcgctggt
    13981 cgaccacggc gccgcgctgc gccgcatcgg cctgccccag gaggccggcg accggctcta
    14041 ccgcggtctg gagggagcgg tgcgctgcgg ggccgacgcg ctcgccgccc gggcccgcga
    14101 cgagctgtcc gcggccgggc tgcgcccgat gcagctgcgg gtggatcaca ccagcccgct
    14161 gacctcgcag gagcaggcca tcgccgagcg ggccgccgag ggctggccgg acgcccggat
    14221 cagcgagacg accgggctcg aggagcgcga ggtcgcccgg ctgctctccg atgtctaccg
    14281 taaggtcggc accgaccggg ccgggctggc gaagcggctc atcacgccca ccgtcggcct
    14341 tccccagcgc ccggtgcccg accccgaatg aggggtgcgg cccgtccgcc acccggcacg
    14401 ggaacgggcg cgcggccacg taccatgtcc gcatgtcctt cctccgccgc cgcagcgccg
    14461 ccacgcccac cgggccggac ttcgatgtcc tcgccatgga cccgggagac tggcccggcg
    14521 atctcggggc ggggctgctg cccgcccccg acggcacctg ccagggcgtc ttcctgcgct
    14581 acgacctgtt cggcgggcgc ggcccggcca tgatcatcgg caatctgccc gaggggtccc
    14641 cggccaggga ggtggccgag gggcagccgc cgttcgaggt gacccagctg ctggcggcgc
    14701 tcgggaacga tgagccggtc caggtggtgg acaccgagga cagcccggtc atgcatgagg
    14761 acaacctcct catcgtccgc cggatcaagc tctccgaggg ccggatctcc tgtgcccagt
    14821 tcgaccgcag cgacggtgtg ctcgtcacca tcgccagctg ggaccggccg atcaccgacg
    14881 atctgtaccg gctgctcaag ccgctgcccg cggagatgtt ccagcagcgc tgaggggccg
    14941 ccgcgaaggg ccgtgagacg cccgtacggc acgaggccgg tacggccgcg cccacggccc
    15001 ctcttctgcc gctcttccac ggcggattga cggcccatca ggcccatcga tccatcaggc
    15061 ccactgaccc atcagtctca cttcccggag cgccggaccg tcacatcggc ggcccggacg
    15121 aacgccaccc ggtgcccgaa ctggatctgg tagtacacat cctggccgcg caccaccttg
    15181 tgaccggccg gatcgaaggt ggtcgcccac agatactcgc cccgcgtccg cagccccagc
    15241 ggataggact gcccggcgag cagcttgtac ggcagtggcg agaccgcctg caccggcacg
    15301 ccctccggat acgcctcctt ctccggatag gcgcggccgt acaccgcgac ctccgccgcc
    15361 ccgcccttgg gcgtcaccac aagtcccttg gcgctcacgg ccgtcggccg ccgcttgggg
    15421 ttctggaacc aggcgcgttg gccgaggtac cagatcgccg tccagtcgcc ctcgtgcccc
    15481 gcgaccgcga actgctgccc ggtggtggca cgggccccgg tgtcattgac accggtcgtc
    15541 gagtcggagc cgtccgggcg cagcccgatg tccttgacca gcggggcgtc cgcgctcggc
    15601 gcggtgtgca gccgcaccgc ggccgagccg tgcggggcgc atgcctggcc cgccgtctcg
    15661 cagtcggtgt agacgggccg gttggtgtcg tagtcggggc ggatggtgac caggccgccg
    15721 gaggagcccg cggtgcgttg gaagggcgcg ccgagcaggg tgaagtagtg cgcccagtcc
    15781 cagtaggggc ccgggtcggt gtgcatgccc gggatggtgc cggtggtggt gcccggcaca
    15841 ttgtcatgac ccaagatgtg ctggcggtcc agcggaatgt cgaaccgctt ggcgagatag
    15901 cgcaccagcc gcgccgagga gcggtacatc gcctccgtgt accaggcgtc gggggcggtg
    15961 aggaaaccct cgtgctccag gccgatggac ttggcgttga cgtaccagtt gcccgcgtgc
    16021 caggcgacgt ccttcagcgg cacatgctgg gcgatatggc cgtcggagga gcgcagggtg
    16081 tactgccagg acacataggt ggggtcctgg accagcttga gggtggtgtc ccaggagccc
    16141 tcggtgtcat ggatgacgat gtagtcgatg gactgcgagg aggggcgctc gcccaggtcg
    16201 tggttgccgt agtcgttgtc cccgaactcc tcgtagggcg ccgggagcca ctcgcaggac
    16261 acgtccttgg gggcctcgac ccgcggatcc cgggcggggg aggccagacc gagcgtccgc
    16321 agctgccggg tgtccggcgc gacagcgggc gccgcgtcga gggagacccg ctcgccgtcg
    16381 gcggtcgtcc gcgaggcacc gccgcggatc accgagtaca cctcgtcggc gaagacgccc
    16441 gcggccgtgg cgtcatcggc gcccgagtag gccgccaccg ccgcgtacca gtcggcgggg
    16501 tcctcgctcc gcggcagccc cagccgcttc tgggcggcgg ccagcagggc cgcgccaccg
    16561 cgcacattgg cgctctcatc gccgcgcagc gcctccgcgg acagcccggt gagctccgcg
    16621 gcccggccga gggtgcgcag ccgcgcgggc agccgccggg gctcgggaac ggtggccttg
    16681 gggacccgca ggggccgggc gagatcgccg cgcgcgtcct cggtgccctg gctgtggtgc
    16741 ggggcgccga gcagggcggt gtgggcgtcg gtgagatgca tggggccata gccgccggtg
    16801 acgctcggcg caccgcggtg gccgtcccag cgcgactgga gatacgagac gcccaggagc
    16861 acgctcagcg gaacgccgta ctcggcggcc gcggccgcga aggcacgctg caatgcgccg
    16921 ccgtcggccg gaggaccctc ggccccctcg gcccgtgact ggtcggcatg ggccgcgggt
    16981 gtcgccgcga ccaacgggag cagaaacgcc gcggacgcca cggctcccgc ggtccgcagt
    17041 gtggttcgcc gggtgggacc ggacgggtct ctgttcgcgt cgtgggcgct gtcctgtgcg
    17101 gattctggca ttgcagcctc ctcaagcggg ccggggcgag ccgagccact tagagatatg
    17161 cgctgccagg cgtggcgtca atcgccgtca cccggacgga cgttcggatg tcggcccgcc
    17221 tgcggcgcgt caccggtcca gaccggtgac gcgcccggac gccactccgc ctccgctcag
    17281 cgggtgccga ccgccgcccg caccgcgcgc cgggccagcg cgcagtcgtc atgcagccgg
    17341 cgcagcagca gccgctgctc ctcaccggcc ggaaccgcgc ccggcaccac cggggcgggg
    17401 tcgtgcatgg tgcgctgcac cgcggtctcg tactggcgga tctcccgcgt cagcaccagc
    17461 atcagattca ccaggaagga atcccgcgtg gccgggcccg cggcctgcgc cagctggctg
    17521 atctggcgcc gggtcacggg ggcgtcgccg agcaccgtcc acagcgtggc caggtcatag
    17581 ccgggcagat accagcccgc gtggtcccag tcgaggagca ccgggcccgc gggggagagc
    17641 aggacattgt tcaacagggc gtcgccatgg gagaactggg ccggggtctg ccgcccacag
    17701 gtctgcgaga cgccgcgcag cagcttctgt agatcgccca tgtcccggtc ggtgagcagc
    17761 ccgagctcgt gatagcgggt cagccggacg gcgtagtcga tgggggcgtc gaacagaccg
    17821 gcgggcgggc gccactggtt gactcggcgg atcgcgccca gcacggcccc cagatcggcg
    17881 cgcggcggag gttcggtggg gtggcgctgc gcggccgcga tccgcccggg catccgctcg
    17941 atgaccagcg cgcagttgtc cgggtcggcg gcgatcagcc ggggcacccg caccggcggg
    18001 cgctggcgga cgaacgcccg gtacatcgct atttcccggc ggaaccgctc ggcccacgcg
    18061 ggggagtggt ccagcaggca cttggccacc gcggtgctgc gcccggtcgc gccgatcaga
    18121 agcacggacc ggccgctgcg ccgcagcacc tgcaccgggt tgaactccgg acagatgcga
    18181 tggaccgagg tgatcgcggt gcgcagctgc gcaccctgag gaccggacaa atcgagtctc
    18241 ccgcggggcg gcacggggcc gagggcggcg gtccgccggg tccggccgcc gggggcggga
    18301 tcgaggtacg gcccagtgcc gggcagctgc cgccggtacg gccggggcgg ggcggacacg
    18361 gaggacgatg ctgcgtacat gggcgataca gatcccttcg tgtgccgacg aattgcgtac
    18421 gcacccggcc ccggggcggg accgcaccct ggggaatgcg gccgatccag cgcgagccgc
    18481 caccgggccg ggtaacgcgc tcctacatca cacccgtgtg cgggtggcac accatctggc
    18541 ggaccctggc gaaccctggc gaatagtcgc accgctcgtg acggggccgt tactgtcaag
    18601 tcagccgagg aacctggggg cttgacgtga cgagggaacc caacacccgt cttgcggacc
    18661 tgttcggcct cgccggatgg tccaaggggg aactcgcgag actcgtgaac cggaaggcgg
    18721 cggccatggg ccatccgcag ctggcgaccg acacctcgcg ggtgcggcgt tggatcgaca
    18781 ccggcgagac gccgcgcgat cccgtgccca aggtgctggc ggccctgttc accgagcgcc
    18841 tcggtcgagt cgtgaccatc gaggatctcg ggttcggacg cggggggcgc gcgggaaagg
    18901 ggcagtccgg cgacgggctg ttctggccgc ccgagtccac cgccgcggtc ctcaccgaat
    18961 tcacgggaat ggaccttatg ttcaaccgac gcggcttggt gggtgcgggc gccgcgctcg
    19021 ccgcaggatc cgccatcacc ggtgccatga gcgactttct gctctccgac cccaccctcg
    19081 ccaccgacgc gccccgtacc gacaaccccc tgtccgtcga gcccgtgggc ttcgaccgct
    19141 atgaggccgc ccccgtgggc tcccaggaga tcgacgccct ggagggatcg gtcgaggtct
    19201 tccgcgcctg ggacgcggcc cgcggcggcg ggctccagcg caaggccgtg gtcggccagc
    19261 tcaacgaggt gggcggcatg ctcgcctacc gtcaccccga acaccttcag cgccgactgt
    19321 ggggggtggc ggccaatctg gcggtgctcg ccggctggat gtcccatgac gtcggcctgg
    19381 agccgaccgc ccagaagtac ttcgtcatcg ccgcgcacgc ggcccgcgag ggcgacgacc
    19441 ggccccgggc gggcgaggcg ctctcccggg ccgcccggca gatggtgcac ctgggccgcc
    19501 cggacgacgc gctggatctg atgaagctgg ccacgtccgg tgcgggcgag caggcgctgc
    19561 cgtgcacccg ggccatgttc cgcaccatcg aggcatgggc gcaggcgtcc aagggccacg
    19621 gccaggcggc gcggcgcgcc ctgggcgagg cggaggagct gttcgtctcc gacggggacc
    19681 acgggccggc gcccagctgg atgcagctgt tcaacgaggc tgatctgcac gggatgcagg
    19741 ggctggtcta ccgcaccctc gccgagcacg agccggcggc ggccgggatc gccctgaacc
    19801 atgcgaagaa ggcgctgcgg atgcgggagg gcgggcgcca gcggtcccag atcttcgacc
    19861 acatctccat cgcctcggcc tgtttcatcg gcgacgaccc cgagcaggcc gagcgctacg
    19921 cccggacggc cctgctgacg atcgagcaga actcctcgca ccgcacctgg gaccggctgc
    19981 gcgagatgta ccggctcacc gcgcggtacg gcacctcacc ggccgtccgg gagctgcggg
    20041 aggagatcca gcgggcactg ccgaagggag gcgcgggaaa gggcggcgcg gggctgaaag
    20101 gatccggctc catcgccagg agcgcggccg tctagcgtcc gggccacgcc ttacggggct
    20161 tacgaggagc ttgctcgcgc tacgaggagc ttgccttacg aggggcatga cgaagggccg
    20221 gaggggccgt acgaagggct ttacgcgggg caacgtctta cggggagtcg acgccttacg
    20281 ggggtcacgc cttacgaggg tcacgcctta cgcggtgcga cgccttacga ggtcgggcac
    20341 cgcttacgag gggtcgatca ccgcgtcatg ccgacgcggg aagccgcgtc atgcgcgggc
    20401 ggcggtgacc ctggcgatca gcacacaggc gtcgttcgca cgcggctcgt cgccgaacgc
    20461 ctcggccacg gtccgtacgc actcctgggc gccatgggcg gcggtcagcc gtggtgcgag
    20521 cgcgagcagc cgctcggtgg cgccctcggc gtcccgggcg agccgtccgg tgtgcagcac
    20581 cagcagatcg cccggctcca gccgctcctc ggcctgggcg tacgcggcgc ccgtcgtggc
    20641 gcccagcagc acgccgccgg gagagcgcag cgggcgcccc gtcccgtcgc ggaagagcag
    20701 cggggcgggg tgtccggcct gtgcccagag cagggtgcgg gtgtccgggt cgtactgtcc
    20761 gcagacggcg ccgaccagcg cgggctggga ggagacggcg agcagttggt tgagccgacc
    20821 catcagcggg cccggctcga tcccggccac cgccatgccg cgcaccgcgc cgagcagcat
    20881 ggccataccg caggtcgcgg tcactccatg gccggtgagg ccgccgacgc tcagcagggt
    20941 ccggccgtcc ggcagttcca gcgcgtcgta ccagtcgccg ccgatccggg cgctggactc
    21001 ggagggcagg tagtgggcgg cgaggtcgag ggcggcgccg tcatccggtg gttcggcgcc
    21061 cggaaagccg tcgcgggccg gaagccggag ggagccgcgc cacggcggca gcacggcctc
    21121 ctgcacctcc accgcgagcc gacgctcggt ccgcgcgatc cgccgctggt ggcgcagggt
    21181 gtcccggctt t
//
