LOCUS       NZ_CP025018            12397 bp    DNA     linear   CON 12-FEB-2024
DEFINITION  Streptomyces sp. M56 chromosome.
ACCESSION   NZ_CP025018
VERSION     NZ_CP025018.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. M56
  ORGANISM  Streptomyces sp. M56
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11742376)
  AUTHORS   Kim,K.K.Hyun., Klassen,J.L., Ruzzini,A.A.C., Beemelmanns,C.C. and
            Clardy,J.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-NOV-2017) Leibniz Institute for Natural Product
            Research and Infection Biology - Hans Knoll Institute,
            Adolf-Reichwein-Strasse 23, Jena 07745, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-AUG-2014
            Assembly Method                   :: HGAP v. AUG-2014
            Assembly Name                     :: M56v2
            Expected Final Version            :: yes
            Genome Coverage                   :: 94.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/12/2024 06:37:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,558
            CDSs (total)                      :: 9,473
            Genes (coding)                    :: 9,167
            CDSs (with protein)               :: 9,167
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 306
            CDSs (without protein)            :: 306
            Pseudo Genes (ambiguous residues) :: 0 of 306
            Pseudo Genes (frameshifted)       :: 86 of 306
            Pseudo Genes (incomplete)         :: 261 of 306
            Pseudo Genes (internal stop)      :: 28 of 306
            Pseudo Genes (multiple problems)  :: 61 of 306
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:58:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6937784
            Orig. end                         :: 6950181
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP025018.1.
            Annotated using prokka 1.11 from http://www.vicbioinformatics.com.
            Bacteria and source DNA available from Christine Beemelmanns.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12397
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="30"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..12397
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12397
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:7397](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7397)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(309..323)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    974..987
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.81"
                     /tool="antismash"
     gene            1412..2680
                     /locus_tag="CFP59_RS29120"
                     /old_locus_tag="CFP59_05744"
     CDS             1412..2680
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060950.1"
                     /locus_tag="CFP59_RS29120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_05744"
                     /product="M6 family metalloprotease domain-containing
                     protein"
                     /protein_id="WP_100807127.1"
                     /transl_table=11
                     /translation="MVRPQVPEGVHQQPRLRRTQALLTSLSALIATTVVAGPAVAAGPG
                     GPCDLERTDAHHSEGLDTWNSRYPRPVRRLDAAMVFLSFPDARPRVTPARLAADHIPAT
                     PDFFKRASYGKFALRVHPLRRWIAMPQRSTAYAIQRDWNAQRRAAYLRDAIASADPHLD
                     FGRYDLVYLVADPDAPGVDADATKVVNFEKPLRADGVDLRRLVTVFEHHPPDRNVLAHE
                     TGHVFDLPDLYHRPKDTDGNAEWDTYVGDWDLMGSQFGMAPDPFGWHKWKLGWLGARQV
                     ACDRLTGPRRYTLQPLSAPMARGGPGADLRTRLVVVRTGPTTALAIEARGGRGNDAGTC
                     TEGVLVYRVHNDKASGDGPVQVLDGHPTTSACWNESVYPELADAPLGVGDTLSVKEDDV
                     RITVAGRAADGGWTVRVNRQAPG"
     misc_feature    complement(2725..2734)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(2858..2873)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.87"
                     /tool="antismash"
     gene            2908..3513
                     /locus_tag="CFP59_RS29125"
                     /old_locus_tag="CFP59_05745"
     CDS             2908..3513
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009717663.1"
                     /locus_tag="CFP59_RS29125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_05745"
                     /product="response regulator transcription factor"
                     /protein_id="WP_079257772.1"
                     /transl_table=11
                     /translation="MVRVLIAEDMHMLRKALVALLEFEPDIEVVAEFPDGADILPRARE
                     LRPDVAVLDIDLPGMDGLTAAAELSTAVPECRTMMLTSLGRPGNLRRALAAHVSGFLLK
                     DSSPEKLSDAIRAVAKGERVIDPQLALAALDDGPQPLTPRELEVLRFAAKGEDSGQIAA
                     KLFLSVGTVRNYLTSAVTKLDARNRVDAIRIAREAGWL"
     gene            complement(3624..4862)
                     /locus_tag="CFP59_RS29130"
                     /old_locus_tag="CFP59_05746"
     CDS             complement(3624..4862)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060948.1"
                     /locus_tag="CFP59_RS29130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_05746"
                     /product="histidine kinase"
                     /protein_id="WP_231981439.1"
                     /transl_table=11
                     /translation="MPDGAGNHPPRHHDDLAPRLAVVITVIVLVGYFSVAVTYVVDGNR
                     SGGTIDAAMLALALLPMTVLLCLQMLHSFPGLAPRLSRARHWTLALQAVLTFAPFAIFK
                     HAWLGMPGFLAGSSLLVLVPALAWPAFAAILLCTDVLLFQVGFGWGQVAYTSVSTALTG
                     LVVFGLSRLSGLVAEVSRSRAELARLAVAQERLRFSRDVHDLLGYSLSTITLKCELVHR
                     LVPRQNSRAQQELSEILQTSRQALADVRAVASGYRKMSLSAEAATARSMLAAAGISATA
                     EIDCAPLPELVDTVLASVLREGLTNVLRHSKADHCAFEARRSGHRVWLTLVNDGVGRPS
                     TILRADSTDGGSGIGNLRVRVENLGGRLRAGVRSDGWFELRAELDVSVAAPRRSGRERG
                     SEEEYGPGPTVTA"
     misc_feature    complement(3723..3725)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4816..4836)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.94"
                     /tool="antismash"
     misc_feature    complement(4971..4984)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.07"
                     /tool="antismash"
     gene            complement(5001..7397)
                     /locus_tag="CFP59_RS29135"
                     /old_locus_tag="CFP59_05747"
     CDS             complement(5001..7397)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cyanobactin_D_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Goadsporin_CD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NHLP_CD_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060947.1"
                     /locus_tag="CFP59_RS29135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_05747"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_100807128.1"
                     /sec_met_domain="Cyanobactin_D_RRE (E-value: 6.1e-12,
                     bitscore: 44.5, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="Goadsporin_CD_RRE (E-value: 7.2e-18,
                     bitscore: 63.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="NHLP_CD_RRE (E-value: 8.7e-15, bitscore:
                     53.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 1.2e-81, bitscore: 274.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 9.3e-70, bitscore:
                     234.4, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGELGFTPHLRVEPVPGEAVYLVSEHGVTALHGQAIAALAPLLD
                     GSRDLAHILTEAAAPARAADPAGAVPAGQAERVIARLRAAGLVSERKRASTPEAAYWEL
                     AGPAAVGGPTPAPAPRASRPAVAPLVLGSADPGEVVRALRAAGLRTAASRTVGGAAADR
                     GAVDGDPTVSGAATPRREICQIAPRQHGDTELTLVVCDDYLDPRLAAVDAAHRAAGLRW
                     LPVKPVGTQAWLGPFLGAPDDPCWVCLADRLWRGRQAEAYLQRRLGRPGPVPRPPASLP
                     ASRAAALQLAALEAAKWLAGHRHPGQRELRTLDSLAATVDRHPLARRPQCADCGDPALV
                     AARIRAPLSLPSPRDPLIGTDADTSPRGIADTSPRGIMERYGHLVDPVTGLVTEIRRDP
                     RGPAVLNCFHARHPSYAGAGPHSGLDAVRAGLRAAAHGKGRTAEQARASALCEALEHYS
                     GHFQGDEPRQRARYRDLRPDDAVHPDTVQLFDPRQFRDPALPARHRINDPFDEGAELDW
                     TPVWSLTAERHRLLPTALLYYGAPQPPGGRCCRADSNGAAAGGTLADAVVRGFLELVER
                     DAVALWWYNRTRQPAVALDAFDDPWLAEVRAAHRGVRREVWALDLTTDFGIPVVAALSR
                     RLDKPAEDITLGFGAHFDRHTALCHAFAELNQMLPAVVEARADGGGYGAAEPEALRWFR
                     TATLADHPYLTPDPAAPPPPISGPPEGDATAAVRELARGRGMELLVLDQTRPDVGLPVA
                     KVLMPGMRPHWARFAPGRLFDVPVALGRLSAPTPYADLNPIPFFL"
     aSDomain        complement(7080..7388)
                     /aSDomain="Goadsporin_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     goadsporin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CFP59_RS29135_Goadsporin_CD_RRE.1"
                     /evalue="2.10E-20"
                     /identifier="RREFam013.1"
                     /label="CFP59_RS29135"
                     /locus_tag="CFP59_RS29135"
                     /protein_end="106"
                     /protein_start="3"
                     /score="63.6"
                     /tool="antismash"
                     /translation="ELGFTPHLRVEPVPGEAVYLVSEHGVTALHGQAIAALAPLLDGSR
                     DLAHILTEAAAPARAADPAGAVPAGQAERVIARLRAAGLVSERKRASTPEAAYWELAG"
     aSDomain        complement(7089..7388)
                     /aSDomain="NHLP_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     NHLP/Nif11 LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CFP59_RS29135_NHLP_CD_RRE.1"
                     /evalue="2.60E-17"
                     /identifier="RREFam015.1"
                     /label="CFP59_RS29135"
                     /locus_tag="CFP59_RS29135"
                     /protein_end="103"
                     /protein_start="3"
                     /score="53.6"
                     /tool="antismash"
                     /translation="ELGFTPHLRVEPVPGEAVYLVSEHGVTALHGQAIAALAPLLDGSR
                     DLAHILTEAAAPARAADPAGAVPAGQAERVIARLRAAGLVSERKRASTPEAAYWE"
     aSDomain        complement(7134..7388)
                     /aSDomain="Cyanobactin_D_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing D protein in a cyanobactin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CFP59_RS29135_Cyanobactin_D_RRE.1"
                     /evalue="1.80E-14"
                     /identifier="RREFam007.1"
                     /label="CFP59_RS29135"
                     /locus_tag="CFP59_RS29135"
                     /protein_end="88"
                     /protein_start="3"
                     /score="44.5"
                     /tool="antismash"
                     /translation="ELGFTPHLRVEPVPGEAVYLVSEHGVTALHGQAIAALAPLLDGSR
                     DLAHILTEAAAPARAADPAGAVPAGQAERVIARLRAAGLV"
     misc_feature    complement(7362..7376)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.88"
                     /tool="antismash"
     gene            complement(7405..7659)
                     /locus_tag="CFP59_RS29140"
                     /old_locus_tag="CFP59_05748"
     CDS             complement(7405..7659)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CFP59_RS29140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CFP59_05748"
                     /product="hypothetical protein"
                     /protein_id="WP_093706874.1"
                     /transl_table=11
                     /translation="MTDTPVPNESTSPAGLAYSAENTEVTGVAEITERVRFAARAGAVG
                     AAEAVHPPVEADDLVIEDLSEAVWAVPAAGICICTVGAE"
     misc_feature    7710..7724
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.49"
                     /tool="antismash"
     gene            7843..8667
                     /locus_tag="CFP59_RS29145"
                     /old_locus_tag="CFP59_05749"
     CDS             7843..8667
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060945.1"
                     /locus_tag="CFP59_RS29145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_05749"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_030836626.1"
                     /transl_table=11
                     /translation="MDIKVLGPLSVEACGQSIVPSAGKPRQILALLSVYANQMLPVPTL
                     MEEIWGTQMPRSALTTLQTYILQLRRRLAAAYGPQAPQASKDVLATRYGGYVLEAQPGA
                     VDIHEYDRLVAAGREALDAGDDVQASLLLREALAVWRGPALVDVKVGPVLEIELARLEE
                     SRLGVLERRIEADLRLGRHAELLTELTELTARHPLHEGLHAQCMAALYRAGRPWQALEV
                     YQGLRARLVEDLGLEPSPRLQKLQQAVLASDPALDLDLDGHWRRPVLDLFAA"
     misc_feature    complement(8672..8686)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.62"
                     /tool="antismash"
     gene            9002..10234
                     /locus_tag="CFP59_RS29150"
                     /old_locus_tag="CFP59_05750"
     CDS             9002..10234
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060944.1"
                     /locus_tag="CFP59_RS29150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_05750"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_231981440.1"
                     /transl_table=11
                     /translation="MREIDTDVCVVGGGPAGLVLALLMLRSGARVTVLECARAHQRVVR
                     GEILQPGAMELLDALDVLSGARARGAHEHHRFLVMEGERVLLEADYRLLPAPYDHLLSV
                     PRPHLLDELLARCRRSPGFRYLPGRRAGGLLRRDERIAGVIADGPPGRCAVRARVVVGA
                     DGRFSRVRRLAGIGAGRAEAFAQDVLWCALTASPEEPPVRDVRVFRTGGGPVLVYGSWP
                     NRIQIGWTLPHRRYGHLAALGLDHVKERLVRAVPRYATLIRDQIRTPADLGVLDVFSAR
                     AERWAADGLVLIGDAAHTHSPIGAQGINLAVQDAVVLHPLLTRALSEGDTSAERLAEFE
                     RRRGPDIAAVMRMQTLQSRAILSQGAFTTRVRPRLARALRRTPLYRKILQRMAYGNPSI
                     RIADAGVCGRT"
     gene            10325..11275
                     /locus_tag="CFP59_RS29155"
                     /old_locus_tag="CFP59_05751"
     CDS             10325..11275
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060943.1"
                     /locus_tag="CFP59_RS29155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_05751"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_069863907.1"
                     /transl_table=11
                     /translation="MHTVVILALDQVIPFDLATPIEVFTRTRLPDGREPYRVRVCGPTP
                     TIDAGVFALQAPYGLEALAEADTIVVPGRSDPLLPVPAEVNDALRDAAGRGTRIASICS
                     GAFTLAATGLLDGHCATTHWLGGALLAELHPKIQVDPDVLYVDNGQFLTSAGAAAGLDL
                     CLHIIRRDHGSAVAADAARLSVMPLEREGGQAQFIVHDQPPVPRGSLFEPLLRWMEDNA
                     ARDLTLTEIATHAGMSTRTLNRRFREHTGTTPLQWLHRARIRQAQYLLEATTHPVERIA
                     TQVGFGSPTSFRDRFKRVVGTSPHSYRSAFRRNAG"
     gene            11419..12126
                     /locus_tag="CFP59_RS29160"
                     /old_locus_tag="CFP59_05752"
     CDS             11419..12126
                     /NRPS_PKS="Domain: PKS_KR (9-92). E-value: 2.3e-08. Score:
                     26.1. Matches aSDomain:
                     nrpspksdomains_CFP59_RS29160_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060942.1"
                     /locus_tag="CFP59_RS29160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_05752"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_100807130.1"
                     /transl_table=11
                     /translation="MLDLGLEGRTVLVTGATGGIGRAAARAFAEQGARVALAFRHRREA
                     AEALADELSGSDRGGAFAVPYALDDAASPRWVVAAVEERWGGLDVLVATARRRGARREP
                     HTRFEDVPEEHWRPLVTDGFAPAIRTVQWSLAGMRKRGWGRIALVAAPYAADGDPGGEF
                     HAVARAGLHGLVRGLVDEVGGDGVLINAVCPGPTPPDRPPTTPEDIARTLLFLCSAANG
                     TVTGEALTLAGRR"
     CDS_motif       11446..11520
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CFP59_RS29160_0001"
                     /evalue="1.80E-09"
                     /label="PKSI-KR_m1"
                     /locus_tag="CFP59_RS29160"
                     /protein_end="34"
                     /protein_start="9"
                     /score="30.2"
                     /tool="antismash"
                     /translation="TVLVTGATGGIGRAAARAFAEQGAR"
     aSDomain        11446..11694
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CFP59_RS29160_PKS_KR.1"
                     /evalue="2.30E-08"
                     /label="CFP59_RS29160_PKS_KR.1"
                     /locus_tag="CFP59_RS29160"
                     /protein_end="92"
                     /protein_start="9"
                     /score="26.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TVLVTGATGGIGRAAARAFAEQGARVALAFRHRREAAEALADELS
                     GSDRGGAFAVPYALDDAASPRWVVAAVEERWGGLDVLV"
ORIGIN
        1 cctccttggc ccagtacagc gtggtgtccg cggcctgcat cagccaggtg gtgtgggtgc
       61 cggccgcggg ccgctccacc acgccgatgc tcgccgacac cgacagccgc tgcccgccca
      121 cgtcgaacgg ctcctgaagg gcggccagca ccgaccgggc gaggtcgcac agctgctcgg
      181 tcccggtgga gttgcggacc agcagggcga actcgtcccc gccgagccgc gccaccagat
      241 ggccgccggg cgccgcgcag tcgatgagcc gctgggcgac cgcgccgagc agccggtcgc
      301 cgacccggtg gccgagggtg tcgttgaccg ccttgaagcc gtccaggtcg agatagcaga
      361 gcccgatccg gccggtgccc tcgtggtcgt aggtggccgc ctccagcgcc gaggtcatcc
      421 gctcgaagaa caggctgcgg ttgggcagcc tggtcaccgg gtcgtgcatc tggagatggc
      481 gcagccgccc ctggagatcc cgctgatcgc tgatgtcggc catggacagc agcagactgc
      541 aactgtccgg cgccggctcg acggtgatct cggcccacag ggcatggccg tcggcgcgca
      601 gcagccgccg ggtgcggcgc agccgcgcga ggcggccgcc caggacctcc cggtactccc
      661 gccaggtgcg cggatcctcg tgcagatcgg ccaggtcggc cgcgctgcgg gtggtcagca
      721 ggcccggatc ggtgccgagc agggcgccga gcgcggggtt ggcgtcgagc accctcccct
      781 cgcggtcgac gaccgccatg gccaggcgcg ccgcgttgaa ggcggcgcgg tagtcgccgg
      841 gcgccgggcc cggggtgtgc ccggcgcccg ggggcgtgac cgggctcggg ggcgcgcccg
      901 ggaccgacgg cgcgcttggg gccggacgtg gtgcgccggg gtcctccgcg acagggagga
      961 cgctcgggat ggcatcacgc tctgtgatcg cgggcagcgt cgcgcccggg gcgcggccct
     1021 gcccgtcggg ggttccgctc accgctcgct cccgcgtggc gtttgttgtt tccaagttgt
     1081 tcgtacacat cttgcgcatg tctcacaccg ggtgccgggc agaccgtaat tgcctgcctg
     1141 aagggggatt ccccgctgaa gatgtgccga tcataggggc tcgtacttcg ggcgttccat
     1201 cgacgtcatc gcgctcaccg ccgccttgac aatgtgtttg gtcgtatctg ttcgactctg
     1261 cgcgtgcaaa cagccgctct gaccgaatgt gaccgtctgt tacgtacccg gatagcggcc
     1321 tcttcactcg accagcccaa ctcaacaggg cgtaccccgc caattcacct cagggtggag
     1381 tgggtgttcc gactacgccc gggaggtcga catggtgcgt cctcaggtac ccgagggagt
     1441 gcaccagcag cctcggctgc gtcggaccca ggccctgctg acctcgctga gcgcgctcat
     1501 cgcgaccacc gtggtggcgg gccccgccgt cgccgcgggc cccggcggac cctgtgacct
     1561 ggaacgtacc gacgcccacc actccgaggg cctggacacc tggaactccc gctatccgcg
     1621 cccggtacgc cgacttgacg cggcgatggt cttcctgtcc tttcccgacg ccaggcccag
     1681 ggtgaccccc gcccggctgg ccgccgacca tatccccgcg acccccgact tcttcaaaag
     1741 ggcctcctac gggaaattcg cgctgcgcgt acatccgctg cggcgctgga tcgccatgcc
     1801 ccagcggtcc accgcgtacg ccatacagcg cgactggaac gcccagcggc gggccgccta
     1861 tctgcgcgac gccatcgcgt ccgccgatcc gcacctcgac ttcggccgct acgacctcgt
     1921 ctatctggtc gccgaccccg atgcccccgg tgtggacgcc gatgcgacga aagtggtcaa
     1981 cttcgaaaag ccactgcgcg ccgatggtgt cgatctgcgt cgtctggtca ccgttttcga
     2041 gcaccatccg ccggaccgca atgtgctggc ccatgagacc gggcatgtct tcgaccttcc
     2101 cgacctctac caccggccga aggacaccga cggtaacgcc gaatgggaca cctacgtcgg
     2161 cgactgggac ctgatgggaa gccagttcgg gatggcaccc gatccgttcg gctggcacaa
     2221 gtggaagctc ggctggctcg gcgcgcgcca ggtggcctgc gaccgcctca ccggtccgcg
     2281 cagatacacc ctccagcccc tcagcgcccc catggcgcgc ggcgggcccg gcgccgacct
     2341 ccgcacccgg ctggtcgtgg tccgtaccgg gcccaccacc gcgctggcca tcgaggcgcg
     2401 cggcggccgc ggcaacgacg cgggcacctg taccgagggc gtgctggtct accgcgtcca
     2461 caacgacaag gcgtccggcg acggccccgt ccaggtgctg gacggccacc ccaccacctc
     2521 cgcctgctgg aacgagtcgg tctaccccga actcgccgac gccccgctcg gcgtcggcga
     2581 caccctgtcg gtcaaggagg acgacgtacg gatcacggtg gccggccgcg ccgccgacgg
     2641 aggctggacc gtacgggtca accgccaggc gcccggatga tgcggcggcc cgccggccga
     2701 aggcccccgt cccggccggg acctggccgc cttcccgcac cgctgcctgc cggggtggtg
     2761 cggcatgaca agggggcgcg cgatcgcgct cgtgctacgg gatatgcgtt cgacgggcgg
     2821 atttgcccgc gaatcgatgg aaggtccggg agagcggggg aataatcgtc atgcggggga
     2881 agccgggcgg gtggagcagg gggcggcatg gtcagggtgc tgatcgcgga agacatgcat
     2941 atgttgcgca aggccctggt cgccctgctg gaattcgaac cggacatcga ggtggtggcc
     3001 gaattccccg acggggccga catcctgccg cgcgcccgtg agctccgccc ggatgtcgcg
     3061 gtgctggaca tcgatctgcc gggtatggac gggctcaccg ccgcggccga gttgagcacc
     3121 gccgtccccg aatgccgcac catgatgctc accagcctcg gccgccccgg gaatctgcgc
     3181 cgggcgctgg ccgcccatgt ctccggcttt ctgctgaagg acagcagtcc ggagaagctg
     3241 agcgacgcca tccgcgccgt cgccaagggc gagcgggtga tcgatccaca gctcgcgctg
     3301 gccgccctgg acgacggtcc gcagccgctg accccacgtg agctggaggt tctgcggttc
     3361 gccgcgaagg gggaggactc cgggcagatc gcggccaagc tgtttctgtc ggtgggcacg
     3421 gtgcgcaact acctgacgtc cgccgtgacc aagctggacg cccgcaaccg ggtcgacgcc
     3481 atccggatcg cccgcgaggc gggctggctg tagcggcgac cgggccttgc cgcgcggcca
     3541 ctgtctcgcc gcgccgcccc ggttctcgcc gcgcgtcgcg ggccacgccg ccacgggcct
     3601 tgttacgccg ccacgggccc ctgtcacgcc gtcacggtcg gccccgggcc gtactcctcc
     3661 tccgagccgc gctcccggcc gctccgccgc ggcgcggcca cggacacatc cagctccgcc
     3721 cgtaactcga accagccgtc cgaccgcacg cccgcgcgca gccgcccgcc gaggttctcc
     3781 acccgcaccc ggaggttccc gattccgctg ccgccgtccg tgctgtcggc gcgcaggatc
     3841 gtggacggcc tgccgacccc gtcgttgacg agggtcagcc acacccggtg gccgctgcgc
     3901 cgtgcctcga acgcgcagtg gtcggccttg ctgtggcgca gcacattggt cagcccctcg
     3961 cgcaacacgc tcgccagcac cgtgtccacc agctccggca gcggtgcgca gtcgatctcg
     4021 gccgtggcgc tgatgcccgc cgcggccagc atcgagcggg ccgtggccgc ctccgccgac
     4081 agcgacatct tgcgatagcc gctggccacg gcccgtacgt cggcgagggc ctgacgggag
     4141 gtctggagga tctccgagag ctcctgctgg gcgcgggagt tctgccgggg caccagccgg
     4201 tgcaccagct cgcatttgag ggtgatcgtg gacaggctgt agcccagcag atcgtgcaca
     4261 tcccgggaga accgcagccg ctcctgggcg accgccagcc gggccagttc cgcccgcgac
     4321 cgggacacct cggcgaccag cccggacagc cgcgagagcc cgaagaccac cagcccggtc
     4381 agcgcggtgg agaccgaggt gtacgcgacc tggccccagc cgaagccgac ctggaacagc
     4441 agcacgtccg tgcacagcag gatggccgcg aacgcgggcc acgccagcgc cggaaccagc
     4501 accagcagcg atgagccggc caggaagccc ggcatgccca gccaggcgtg cttgaagatc
     4561 gcgaacgggg cgaaggtcag caccgcctgg agcgccagcg tccagtgccg ggcgcggctg
     4621 agccggggcg cgaggccggg gaaggagtgc agcatttgga ggcagagcag gacggtcatc
     4681 ggcagcagcg ccagcgcgag catcgccgcg tcgatcgtcc cgcccgaacg attgccgtcg
     4741 accacatagg tgacggccac ggagaagtag cccaccagca cgatgaccgt gatgaccacg
     4801 gccagacgcg gcgccagatc gtcatggtga cgcggtgggt ggttcccggc accgtcgggc
     4861 aagaggctcc cctgcactcg tcctccggat ggtcgagccg gattgggtgg cttgcccgag
     4921 agtatccgat cttcggtgga ggtggagagg ccgcgtagaa ggctcatggt gtacgcagag
     4981 ttaccgggtg tcacggggaa tcacaggaaa aacggaatcg ggttgaggtc cgcatagggc
     5041 gtgggggccg acagccggcc gagcgcgacg ggtacgtcga agagtcggcc gggcgcgaac
     5101 cgggcccagt gcgggcgcat cccgggcatc agcaccttgg ccaccggcag tcccacatcc
     5161 ggccgggtct ggtccagcac cagcagctcc atcccgcgcc cgcgcgccaa ctcccttacg
     5221 gcggccgtcg cgtcgccctc cggggggccg gatatcgggg gcggcggggc ggccggatcg
     5281 ggtgtcagat acgggtggtc ggcgagggtc gcggtgcgga accagcgcag cgcctcgggc
     5341 tcggccgcgc cgtagccccc gccgtcggca cgggcctcga ccaccgccgg aagcatctgg
     5401 ttgagctcgg cgaaggcgtg gcagagcgcg gtgtgccggt cgaagtgggc gccgaagccg
     5461 agggtgatgt cctcggcggg cttgtcgagg cgccgggaga gcgcggcgac caccggaatg
     5521 ccgaagtccg tggtgaggtc cagggcccac acctcgcgcc gcacgccccg gtgggcggcg
     5581 cgcacctcgg ccagccaggg gtcgtcgaag gcgtcgaggg ccacggcggg ctgccgggtg
     5641 cggttgtacc accacagggc gaccgcgtcc cgctccacca gctccagaaa gccccgtacg
     5701 acggcgtcgg ccagggtgcc gccggccgcc gcgccgttgg agtccgcccg gcagcagcgg
     5761 ccgcccgggg gttgcggggc gccgtagtac agcagcgcgg tgggcagcag ccggtggcgt
     5821 tcggcggtga gcgaccacac cggggtccag tccagctccg cgccctcgtc gaacggatcg
     5881 ttgatccggt ggcgcgcggg gagggcgggg tcccggaact gccgcggatc gaagagctgg
     5941 acggtgtccg gatgcaccgc gtcgtccggg cgcagatcgc gatagcgggc gcgctgacgg
     6001 ggctcgtccc cctggaaatg gccgctgtag tgctccaggg cctcgcacag cgcgctcgcc
     6061 cgcgcctgtt cggccgtgcg gcccttaccg tgggcggcgg cccgcagccc cgcccttacg
     6121 gcgtccagac cgctgtgggg gcccgccccg gcgtacgagg ggtggcgggc gtggaagcag
     6181 ttgaggacgg ccgggccgcg cggatcgcgc cggatctcgg tgaccagccc ggtgacgggg
     6241 tccaccagat gtccgtagcg ctccatgatc ccgcgcgggg aggtgtcggc gatcccgcgc
     6301 ggggaggtgt cggcgtcggt gccgatgagc gggtcccgcg gcgacggcag cgacagaggc
     6361 gcccgtatcc gggccgcgac cagcgccggg tcgccgcagt cggcgcactg tggccggcgg
     6421 gcgagcggat ggcggtccac ggtggcggcg aggctgtcca aggtgcgcag ttcccgctgg
     6481 cccggatgcc ggtgcccggc aagccacttg gcggcctcca gggcggcgag ctggagcgcc
     6541 gcggcgcggc tcgcgggcag ggaggcgggc gggcgcggca ccggccccgg gcggccgagc
     6601 cggcgctgga gatacgcctc ggcctgccgt ccgcgccaca gccggtcggc cagacagacc
     6661 cagcacggat cgtcgggggc gccgaggaac gggcccagcc acgcctgggt gcccaccggt
     6721 ttgacgggca gccagcgaag gccggcggcg cggtgcgcgg cgtccacggc ggcgagccgg
     6781 ggatcgaggt agtcatcgca caccacaagg gtgagttccg tgtcgccatg ttgacgaggg
     6841 gcgatttgac atatctctcg gcgaggagta gcggccccgg aaaccgtcgg atcgccgtcc
     6901 accgcccccc ggtccgccgc ggccccgccc acggtcctcg aggcagcggt cctcagcccc
     6961 gcggcgcgca gcgcccggac cacttcgccc gggtcggccg agccgaggac cagcggggcc
     7021 acggcggggc gggacgcccg gggcgcgggc gccggggtgg ggccgcccac ggcggccggc
     7081 cccgccagct cccagtacgc cgcctcgggg gtcgaggcgc gcttccgctc ggagaccagc
     7141 ccggccgcgc ggaggcgggc gatgacgcgc tcggcctgcc cggccgggac cgccccggcc
     7201 gggtcggcgg cgcgggcggg cgcggcggcc tcggtgagga tgtgggcgag gtcccgagac
     7261 ccgtcgagca gcggcgccag tgcggcgatc gcctgcccgt gcagcgccgt gaccccgtgc
     7321 tcggagacga gatacacggc ctcgcccggc accggctcga cccgcagatg tggtgtgaag
     7381 cccagttcgc cggtcatcgg ccggtcattc ggcgccgacg gtgcagatgc agatgccggc
     7441 cgcggggacg gcccagacgg cctcggagag gtcctcgatg accaggtcgt ccgcctcgac
     7501 gggcggatga acggcctcgg cggccccgac ggccccggcg cgcgcggcga acctgacgcg
     7561 ttcggtgatc tcggcgaccc cggtgacctc ggtgttctcg gcggaataag ccaggccggc
     7621 ggggctcgtg gactcatttg ggacgggcgt atcggtcatc gcggactctc tcatcgccag
     7681 gggtgtgaat ttgtcatggt gcggggctct ggaactcata tcgagctcgt tactccggca
     7741 ctggccgcac aggccgccca caagcgaggc tcttagatgc ctcggtggca gggccgcgcg
     7801 gccaggaggc acttgacgga ccgttgacgg aggtacacga ccatggacat caaggtgttg
     7861 gggccgctga gcgtcgaggc gtgcggtcag tcgatcgtgc cgagcgcggg caagccgcgc
     7921 cagatccttg cattgctttc cgtctacgcc aaccagatgc tcccggtgcc cactcttatg
     7981 gaggaaatct ggggcacaca gatgccacgc agcgcgctca ccactttgca gacctacatc
     8041 ctccaactgc gccgcaggct ggccgccgcc tatggcccgc aggccccgca ggcatccaag
     8101 gatgtgctgg ccacgcgcta cggcggatat gtgctggagg cccagccggg tgcggtggac
     8161 atccatgagt acgaccggtt ggtggccgcg gggcgggagg cgctggacgc cggggacgat
     8221 gtgcaggcat ccctgctgct gcgcgaggcg ctggccgtgt ggcgcggccc cgcgctggtg
     8281 gatgtgaagg tcgggccggt tctggagatc gagctggccc gtctggagga gagccggctc
     8341 ggcgtcctgg agcgccgtat cgaggccgat ctgcggctgg gccgccatgc cgagctgctc
     8401 accgagctca ccgagttgac ggcccgccat ccgctgcatg aggggctgca cgcccagtgc
     8461 atggccgcgc tctaccgcgc gggccgcccc tggcaggcgc tggaggtcta ccaggggctg
     8521 cgcgccaggc tggtcgagga cctcgggctg gagccgtcgc cgcggctcca gaagctccag
     8581 caggcggtgc tcgcctccga cccggcgctc gatctggacc tggacggcca ctggcgccgc
     8641 cctgtgctcg acctgttcgc cgcatagccc ctcgaccgca tagtccctcg accgcataga
     8701 ccgacagccg acagccgaca gctacagccg acagccgaca gtcgatccct gataccgccc
     8761 tcgtccgaag tctcgtcggc cggttcccgt aggtctcgta ggtcccgtac cagccgtccc
     8821 cgtccgatga accatccccc caaaaacgcc cggcgccgcc cttcagccgg gcctgctacg
     8881 gctccgctgc ccgatccccc cgcgcgggca agcggagccg tagcgcgtcc agggagcgtc
     8941 agggggtgcc actggcgccc ggtgcccagg ccctggagcc cgaccagcag gaggcgcgat
     9001 gatgcgcgag atcgacaccg atgtgtgcgt ggtcgggggc ggcccggccg gtctggtgct
     9061 ggcgctgctg atgctgcggt cgggggcccg ggtgaccgtc ctggagtgcg cccgcgcgca
     9121 tcagcgcgtg gtccgcggcg aaatcctcca gcccggcgcg atggagttgc tggacgcgct
     9181 cgatgtgctc tccggcgccc gcgcccgcgg cgcccatgaa caccaccggt tcctggtgat
     9241 ggagggtgag cgggtgctgc tggaggccga ctaccggctg cttccggccc cgtacgacca
     9301 cctgttgagc gttccgcgcc cccatctgct ggatgagctc ctcgcccgct gccgccgctc
     9361 gcccggcttc cgctatctgc ccggacggcg ggccggtggt ctgctgcggc gggatgagcg
     9421 gatcgccggg gtgatcgccg acggacctcc gggccgttgt gccgtacggg cgcgggtcgt
     9481 ggtcggcgcg gacggccggt tctcgcgggt ccggcggctg gcgggcatcg gggcgggccg
     9541 cgccgaggcg ttcgcccagg atgtcctgtg gtgcgcgctc accgcgtcac cggaggagcc
     9601 gccggtccgc gatgtgcggg tgttccgcac cggcggcggc ccggtgctgg tctacggctc
     9661 ctggccgaac cggatccaga tcggctggac cctgccgcac cggcgctacg gccatctggc
     9721 cgcccttggc ctcgaccatg tcaaggagcg gctggtgcgc gccgtgccgc ggtacgccac
     9781 actgatccgc gaccagatcc ggaccccggc cgatctcggt gtgctcgatg tcttctccgc
     9841 ccgtgccgag cgctgggccg ccgacggtct ggtgctgatc ggcgacgcgg cccacaccca
     9901 cagcccgatc ggtgcccagg gcatcaacct cgcggtgcag gacgcggtgg tgttgcaccc
     9961 cctgctgact cgtgccctgt ccgagggcga caccagcgcc gagcggctgg cggagttcga
    10021 gcggcggcgc gggcccgata tcgcggcggt catgcggatg cagaccttgc agagccgggc
    10081 gatcctctcg cagggcgcgt tcaccacccg ggtgcgcccc cgtctcgcgc gggcgctgcg
    10141 tcgtacaccg ctctatcgca agatcctcca gcgcatggcc tacggcaatc cgtcgatccg
    10201 tatcgccgac gccggagtgt gcggccggac atgacccgaa gcgcggtggc cggaattcgt
    10261 gggtggaccg gcttctcgcc accccggcgg tggtgccatg ggccgtacgg cctaggttga
    10321 ggccatgcac actgtcgtga tcctggcgct ggatcaggtg atcccctttg atctggccac
    10381 cccgatcgag gtgttcaccc gcacccggct ccccgatggc cgcgagccct accgggtccg
    10441 ggtctgcggg cccaccccca ccatcgacgc cggggtgttc gccctccagg cgccgtacgg
    10501 gctcgaggcg ctcgccgagg ccgacaccat cgtcgtgccc ggccgtagcg accccctgct
    10561 cccggtcccc gccgaggtga acgacgcgct gcgggacgcg gccgggcggg gcacccgtat
    10621 cgcctcgatc tgctccgggg ccttcaccct cgccgccacc gggctgctcg acgggcactg
    10681 cgccaccaca cactggctcg gcggcgcgct gctcgccgag ctccatccga agatccaggt
    10741 cgacccggat gtgctctatg tggacaacgg ccagttcctc acctcggcgg gcgccgcggc
    10801 cgggctcgat ctctgtctgc acatcatccg gcgcgaccat ggttccgccg tggccgccga
    10861 cgccgcccgg ctttccgtga tgcccctgga acgggagggc gggcaggccc agttcatcgt
    10921 ccatgaccag ccgcccgtac cgcgcggatc gctgttcgaa cccctgctgc ggtggatgga
    10981 ggacaacgcc gcgcgggacc tcaccctcac cgagatcgcc acccatgccg gcatgagcac
    11041 gcgcactctc aaccgccgct tccgggagca caccgggacc accccgctcc agtggctgca
    11101 ccgcgccagg atccgccagg cgcagtatct gctggaggcc accacccacc cggtcgagcg
    11161 catcgccacc caggtcggat tcggctcgcc cacctccttc cgggaccgct tcaagcgtgt
    11221 cgtcggcacc agcccgcaca gctaccgctc cgccttccgg cgaaacgccg gataagccgc
    11281 ttctgcgaaa cgccggaagc cgttcggcga acgccggacg gccgccacat cccggcaggg
    11341 gcgggcgcga gtcgaggctg cctcgagtca cggcggcgac catggccttc tcagtgggaa
    11401 cgaccgcgag gagtgcccat gttggacctc ggcctggagg ggcgcacggt cctggtcacc
    11461 ggggccaccg ggggcatcgg ccgggccgcc gcgcgcgcct tcgcggagca gggcgcccgg
    11521 gtcgcgctcg ccttccggca ccgccgcgag gccgccgagg cgctggccga cgagctgtcc
    11581 ggatccgacc ggggcggggc cttcgccgtg ccgtacgccc tggacgacgc cgcgtcgccg
    11641 cgctgggtcg tggccgccgt ggaggagcgc tggggcgggc tggacgtgct ggtggcgacc
    11701 gcccggcgaa gaggtgcgcg acgcgagccg cacacccggt tcgaggacgt gccggaggag
    11761 cactggcggc cgctggtcac cgacggcttc gcgcccgcga tccgcaccgt ccagtggtcc
    11821 ctcgccggga tgcgcaagcg cggctggggc cggatcgcgc tggtggccgc gccgtacgcg
    11881 gcggacggcg atcccggcgg ggagttccac gcggtggcac gggccgggct gcacggtctg
    11941 gtccgcggtc tggtggacga ggtgggcggc gacggagtgc tgatcaacgc cgtatgcccc
    12001 gggcccaccc cgcccgaccg gccgcccacc acccccgagg acatcgcccg caccctcctc
    12061 ttcctgtgct ccgcggccaa cggcacggtc accggcgaag cgctgacgct cgcggggcgc
    12121 cgctgagccc gccgaggagc gcgggatgcg atgagtcggc tcggtgtcat gtccatcggc
    12181 cggacggggc ggtccggccg gctcgactcc gcgggaggtc accgtgcgcg tcctgttcac
    12241 gacctgggcc tcgggcgccc atctcgtccc catggtgccg ctggcgcgcg ccctgctcga
    12301 ggccgggcac caggtgcggg tcgcggtgcc gtccgcatgc gcggcggccg tcgcccgcgc
    12361 cggcctggtg ccggtgcaga tctgcgccct gcccatg
//
