LOCUS       NZ_CP025018            26454 bp    DNA     linear   CON 12-FEB-2024
DEFINITION  Streptomyces sp. M56 chromosome.
ACCESSION   NZ_CP025018
VERSION     NZ_CP025018.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. M56
  ORGANISM  Streptomyces sp. M56
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11742376)
  AUTHORS   Kim,K.K.Hyun., Klassen,J.L., Ruzzini,A.A.C., Beemelmanns,C.C. and
            Clardy,J.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-NOV-2017) Leibniz Institute for Natural Product
            Research and Infection Biology - Hans Knoll Institute,
            Adolf-Reichwein-Strasse 23, Jena 07745, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-AUG-2014
            Assembly Method                   :: HGAP v. AUG-2014
            Assembly Name                     :: M56v2
            Expected Final Version            :: yes
            Genome Coverage                   :: 94.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/12/2024 06:37:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,558
            CDSs (total)                      :: 9,473
            Genes (coding)                    :: 9,167
            CDSs (with protein)               :: 9,167
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 306
            CDSs (without protein)            :: 306
            Pseudo Genes (ambiguous residues) :: 0 of 306
            Pseudo Genes (frameshifted)       :: 86 of 306
            Pseudo Genes (incomplete)         :: 261 of 306
            Pseudo Genes (internal stop)      :: 28 of 306
            Pseudo Genes (multiple problems)  :: 61 of 306
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:58:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2889387
            Orig. end                         :: 2915841
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP025018.1.
            Annotated using prokka 1.11 from http://www.vicbioinformatics.com.
            Bacteria and source DNA available from Christine Beemelmanns.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26454
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="17"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..26454
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26454
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:16454](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16454)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(557..1354)
                     /locus_tag="CFP59_RS11425"
                     /old_locus_tag="CFP59_02258"
     CDS             complement(557..1354)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713864.1"
                     /locus_tag="CFP59_RS11425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02258"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_093700771.1"
                     /transl_table=11
                     /translation="MADDKERFSNGSIGSYAAVGDSFTEGVGDPGPDGVFVGWADRLAV
                     LLSDQRPQDDFRYANLAVRGRLLDQIVAEQVRRAIELGPDLVTFCAGGNDILRPGSDPD
                     DVAERYEAAVADLRARVGTVLLCTGFDTRGVPVLRHLRGKIATYTAHVRAIADRHGCPV
                     LDLWSLRSVQDRRAWDADRLHLSPDGHTRVALRAGQVLGLDVPADPDQPWPPEGQRTAA
                     EVRRDNIHWAREYLVPWIGRRLRGESSGDHVEPKRPNLLPLRH"
     gene            1674..2498
                     /locus_tag="CFP59_RS11430"
                     /old_locus_tag="CFP59_02259"
     CDS             1674..2498
                     /EC_number="3.1.3.48"
                     /GO_function="GO:0004721 - phosphoprotein phosphatase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056075.1"
                     /locus_tag="CFP59_RS11430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02259"
                     /product="tyrosine-protein phosphatase"
                     /protein_id="WP_069869654.1"
                     /transl_table=11
                     /translation="MPQQSQSPQVPQAETPLVGVRNFRDLGGLPAADGRRVRPGVLFRS
                     GHLAHATEADTAFLDALGLHTIFDFRNAADIKLEGPDVTLRGVRNVNLPLSDPADGAGF
                     WTMVREGDLKTLRELLSEGRAEKRMIGSYRSIITTRLVEHGRILSDMAEDSSPVLMHCS
                     AGKDRAGLSIAVTLLALGVDQETIEADYLESAAAHRRYKIWRKGDPSDSSDPMSPEVMA
                     LLLPLFDARAEYLAAAFATIEETWGGTERYLAEGLGLDPERRERLRERLLTG"
     gene            complement(2549..3742)
                     /locus_tag="CFP59_RS11435"
                     /old_locus_tag="CFP59_02260"
     CDS             complement(2549..3742)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056074.1"
                     /locus_tag="CFP59_RS11435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02260"
                     /product="serpin family protein"
                     /protein_id="WP_100805690.1"
                     /transl_table=11
                     /translation="MIDATAVRAVNAMTARWARAAVTDEGTVLAAAGVWPLLALLAGGA
                     GGPVRQELEGALGVGADAATALGGEVLGALDGMAGVDAATGLWTRRDLPIRSGWEAALP
                     PGVRATLTGDGERDRKELDAWASRRTRGAITEMPVPLTPATLLVLAGALTVRTDWVQPF
                     QPGPLVPRSGPWRDRSLAGLTRFTEDLDGALRVVPDTPAGPLTLSGVAGGNGLDVRLVL
                     GADGVPGGEVLEAGIGAVAGRYEGRPGSALPPGEAGPGVRVMEVPSRDPTPRMALTAPR
                     FTVQARHDLLRRAGLFGLRTAQDASRGHFPGISPAALALSSGEQSITASFSAEGFWAAA
                     VTAFSLAPGSVPPRRPAKLISVRYERPFGFLAVHRASGLVLTAGWVTEPEAGPATIW"
     gene            complement(3759..5165)
                     /locus_tag="CFP59_RS11440"
                     /old_locus_tag="CFP59_02261"
     CDS             complement(3759..5165)
                     /NRPS_PKS="Domain: Aminotran_3 (48-370). E-value: 6.2e-89.
                     Score: 290.3. Matches aSDomain:
                     nrpspksdomains_CFP59_RS11440_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056073.1"
                     /locus_tag="CFP59_RS11440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02261"
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_100805691.1"
                     /sec_met_domain="Aminotran_3 (E-value: 6e-86, bitscore:
                     287.7, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAEQQRRSGFDLGKLLAERASERYDLHTRHLNHQLPRMLHTIG
                     FDKVYERAEGAYFWDDEGQDYLDMLAGFGVMGLGRHHPVVRKALHDVLDADLADLTRFD
                     CQPLPGLLAERLLAHAPHLDRVFFGNSGTEAVETALKFARFVTGKPRVLYCAHAFHGLT
                     TGSLSVNGEDGFRKGFAPLLPDTAIEMGDLAALERELARGDVAGFVVEPIQGKGVHETP
                     PGFLRAAQELLHRHKALLIVDEVQTGLGRTGDFFAYQHEDGVEPDLVCVAKALSGGYVP
                     VGATLGKDWIFRRVYSSMDRVLVHSASFGSNAQAMAAGLAVLAVMEDEEVVANARRTGE
                     LLRDRLAALVDRYELLHDVRGRGLMIGIEFGRPSSLGLRSRWAMLQTARKGLFAQMVVV
                     PLLRRHRILTQVSGDHLEVIKLIPPLIIGEREVDRFVEAFTAVMDDAHEGGGLMWEFGR
                     TLVKQAVANR"
     aSDomain        complement(4056..5021)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CFP59_RS11440_Aminotran_3.1"
                     /evalue="6.20E-89"
                     /label="CFP59_RS11440_Aminotran_3.1"
                     /locus_tag="CFP59_RS11440"
                     /protein_end="370"
                     /protein_start="48"
                     /score="290.3"
                     /tool="antismash"
                     /translation="VYERAEGAYFWDDEGQDYLDMLAGFGVMGLGRHHPVVRKALHDVL
                     DADLADLTRFDCQPLPGLLAERLLAHAPHLDRVFFGNSGTEAVETALKFARFVTGKPRV
                     LYCAHAFHGLTTGSLSVNGEDGFRKGFAPLLPDTAIEMGDLAALERELARGDVAGFVVE
                     PIQGKGVHETPPGFLRAAQELLHRHKALLIVDEVQTGLGRTGDFFAYQHEDGVEPDLVC
                     VAKALSGGYVPVGATLGKDWIFRRVYSSMDRVLVHSASFGSNAQAMAAGLAVLAVMEDE
                     EVVANARRTGELLRDRLAALVDRYELLHDVRGRGLMIGIEF"
     gene            complement(5162..7114)
                     /gene="dxs"
                     /locus_tag="CFP59_RS11445"
                     /old_locus_tag="CFP59_02262"
     CDS             complement(5162..7114)
                     /EC_number="2.2.1.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009240 - isopentenyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dxs"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056072.1"
                     /locus_tag="CFP59_RS11445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02262"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_100805692.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 4.4e-111,
                     bitscore: 369.5, seeds: 174, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPFLENIRGPHDLKALTDEELEALAQEIREFLIKAVARTGGHLGP
                     NLGVVELSIALHRVFDSPADRILWDTGHQSYVHKLLTGRQDFSKLRHKGGLSGYPSRAE
                     SEHDIIENSHASTVLGWADGLAKANEVRGGTDHVVAVIGDGALTGGMAWEALNNIAAAR
                     DRPLVIVVNDNERSYSPTIGGLANHLATLRTTDGYERFLAWGKEVLQRTPVVGQPLYGS
                     LHGAKKGFKDAFAPQGMFEDLGLKYVGPIDGHDTEAVESALRRAKRFHGPVLVHCLTEK
                     GRGYRPALEDEADRFHTVAAMDPLTCAPLAPSGGRSWTSVFGEEMVRIGAERPDVVALT
                     AAMLHPVGLAGFAEAYPERVWDVGIAEQHAAVSAAGLATGGLHPVLAVYATFLNRAFDQ
                     LLMDVALHRCGVTFVLDRAGVTGTDGPSHNGMWDMSVLQVVPGLRIAAPRDADQLRAQL
                     REAIDVADAPTVIRFPKESVGEPIPAIDRVGGMDVLRRGEDVLLVAAGVMADVALRAAE
                     LLAGRGIGCTVVDPRWVKPVDPELPGLAARHRLVAVVEDNVRTGGVGAAVAQTLCDAEV
                     DLPVRTFGIPEAFLAHAKRGEVLADIGLTPAEIAGRIGAALTRIDAARPERAGATAGAR
                     TAAGGRTAAAKESQA"
     gene            complement(7138..8304)
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /locus_tag="CFP59_RS11450"
                     /old_locus_tag="CFP59_02263"
     CDS             complement(7138..8304)
                     /EC_number="1.17.7.1"
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity [Evidence IEA]"
                     /GO_process="GO:0044237 - cellular metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018534474.1"
                     /locus_tag="CFP59_RS11450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02263"
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="WP_079259578.1"
                     /transl_table=11
                     /translation="MSSAEPIALGLPAMPDRPLAPRRVSRRIQVGSVAVGGDAPVSVQS
                     MTTTVTADVGATLQQIAELTASGCQIVRVACPSQDDADALPVIAKKSQIPVIADIHFQP
                     KYVFAAIDAGCAAVRVNPGNIRQFDDKVREIARAASDAGVPIRIGVNAGSLDRRLLEKY
                     GKATPEALVESALWECSLFEEHGFRDIKISVKHNDPVVMVNAYRQLAAQCDYPLHLGVT
                     EAGPAFQGTIKSAVAFGALLSEGIGDTIRVSLSAPPAEEVKVGMQILESLNLRQRRLEI
                     VSCPSCGRAQVDVYKLADQVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGK
                     GQIFVKGEVIKTVPESKIVETLIDEAMNIARRMEDEGVPSGTPDVTVG"
     gene            complement(8309..9334)
                     /gene="hpnH"
                     /locus_tag="CFP59_RS11455"
                     /old_locus_tag="CFP59_02264"
     CDS             complement(8309..9334)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018384766.1"
                     /locus_tag="CFP59_RS11455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02264"
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_069872368.1"
                     /sec_met_domain="PF04055 (E-value: 1.1e-16, bitscore: 60.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 4.3e-08, bitscore: 32.0,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMPLRQTIRVATYLFEQKMIKRRDKFPLIVELEPLFACNLKCEG
                     CGKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIARQLVERKKYV
                     FLCTNAMLLRKKMHLFTPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAIKEAKRRG
                     FRVTTNSTFFNTDTPQTIVDVLDFLNDELEVDEMMISPAYAYEKAPDQEHFLGVEQTRE
                     LFRKAFAGGNRRRWRLNHSPLFLDFLEGKTDFPCTAWGIPNYSLFGWQRPCYLMSDGYV
                     PTYRQLVEETDWDKYGRGKDPRCDNCMAHCGYEPTAVLATMGSLKESLRAARETAAGSK
                     R"
     gene            complement(9285..10001)
                     /locus_tag="CFP59_RS11460"
                     /old_locus_tag="CFP59_02265"
     CDS             complement(9285..10001)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056069.1"
                     /locus_tag="CFP59_RS11460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02265"
                     /product="1-hydroxy-2-methyl-2-butenyl 4-diphosphate
                     reductase"
                     /protein_id="WP_100805693.1"
                     /transl_table=11
                     /translation="MSADPAPEAGGAPLLIACALGIERFALRGAGPGAAGEVTVVRTGM
                     GPQSAERAVTRALTAGSGEWRTAVIATGFCAGLAPGMHPGDLVVADETRDPAGRTVCTG
                     TRILADALSRPLPGGPRRAVHIGPVVGSDHVVRGAERTALHRTGAIAVDMESAATLRTA
                     VGHGVRPVAAVRVVVDAPEHELVRIGTLRGGISAFRVLRTVLPAFFHWHRSSLLPGGEL
                     DGHASPPDHPGRDVSL"
     gene            complement(10001..11947)
                     /gene="shc"
                     /locus_tag="CFP59_RS11465"
                     /old_locus_tag="CFP59_02266"
     CDS             complement(10001..11947)
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014175184.1"
                     /locus_tag="CFP59_RS11465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02266"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_099015468.1"
                     /sec_met_domain="T2TS (E-value: 1.3e-152, bitscore: 508.3,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATPTVQPSESSESKTLSVAREATARAVEHLLSRQDERGWWKGD
                     LETNVTMDAEDLMLRQFLGIQDPDTLDAAARYLRSQQAPDGTWATFHGGPPELSTTIEA
                     YVALRLAGDEPDAPHMTAASAWVRSRGGVAASRVFTRIWLALFGWWRWEDLPELPPEII
                     YFPKWFPLNIYDFGCWARQTIVPLTVVSAKRPVRPAPFPLDELHTDPRKPNPPLPQAPI
                     ATWDGVFQRLDRALHAYHKVALRPLRRSALRSCARWIVERQENDGCWGGIQPPAVYSVI
                     ALHLLGYDLDHPVMRAGLESLDRFAVWREDGSRMIEACQSPVWDTCLAAIALADAGLAP
                     DHPALVKAADWMMAEQIDRPGDWSVRRPGLPSGGWAFEFHNDNYPDIDDTAEVILALRR
                     VDHPEPARIEAAVRRAMRWTLGMQSKNGAWGAFDVDNTSPLPNKLPFCDFGEVVDPPSA
                     DVTAHVVEMLAHEGRTYDARTRRGISWLLSEQEPSGAWFGRWGTNYVYGTGSVVPALIS
                     AGVPASHPAVRRAVRWLESVQNEDGGWGEDQRSYLDAEWMGRGASTASQTAWALLALLA
                     AGEGGGAAVERGVTWLAETQREDGSWDEPYFTGTGFPWDFSINYHLYRQVFPVTALGRF
                     VHGEPTGARPRSS"
     gene            complement(12057..13154)
                     /locus_tag="CFP59_RS11470"
                     /old_locus_tag="CFP59_02267"
     CDS             complement(12057..13154)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713873.1"
                     /locus_tag="CFP59_RS11470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02267"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_069872375.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1e-57, bitscore:
                     194.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTTKNRGETVTSATPAADTAGVMPLLERGRTLATPVLRAAVHR
                     LAPPMNTVAAYHFGWIDAEGNPAEGDGGKAVRPALALLSAEAAGAAPEAGVPGAVAVEL
                     VHNFSLLHDDLMDGDEQRRHRNTVWKEHGPAQAILVGDALFALANEILLEIGTVEAGRA
                     TRRLTAATRKLIDGQAQDISFEHRERVTVEECLEMEGNKTGALLACAASIGAVLGGADD
                     RTADILERYGHHLGLAFQAVDDLLGIWGNPEATGKRTWSDLRQRKKSLPVVAALAAGGP
                     DSERLAQILAADARKPEEEFADFSEEEFAVRAALIEQAGGRDWTSQEARRQHATAMEAL
                     GSVDMPAEIRARFVALADFVVVRKR"
     gene            complement(13151..14635)
                     /gene="hpnE"
                     /locus_tag="CFP59_RS11475"
                     /old_locus_tag="CFP59_02268"
     CDS             complement(13151..14635)
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056066.1"
                     /locus_tag="CFP59_RS11475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02268"
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_231981215.1"
                     /transl_table=11
                     /translation="MTHSALDPAPPAGPRPRGRAALVIGGGLAGTAAALALADAGLRVT
                     LIEGRPRLGGLAFSFHRSSPAGVLSVDNGQHVYLRCCDAYQWFLERVGAARLAPLQGRL
                     DVPVLDARGRSGRRLGRLRRTALPVPLHLSASLATYPHLSLAERAQVGRAALALGRLDP
                     RDPELDGVDFAGWLRRHGQSPRAVEALWDLVGVATLNATASNASLGLAAMVFKTGLLSR
                     PGAADIGWARAPLGELHHTHARRALDAAGVTTELRTRVTGVTRTPEGRWSAATAGRPAD
                     GSPVEADVLVLAVPQREAHALLPDGALKDPGRLLRIGSAPILNLHVIYDRTVLRRPFFA
                     AIGSPVQWVFDRTDASGLRDAPGAGDSQYLAVSQSAAYDDIDRPVAELRARYLPELERL
                     LPVARGARVRDFFVTRERTATFAPVPGVGLLRPSAPTDAPGLYLAGAWTATGWPATMEG
                     AVRSGLSAARTALTDLGRPHVNPLPALGGGTPKEVA"
     gene            complement(14632..15582)
                     /gene="hpnD"
                     /locus_tag="CFP59_RS11480"
                     /old_locus_tag="CFP59_02269"
     CDS             complement(14632..15582)
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056065.1"
                     /locus_tag="CFP59_RS11480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02269"
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_069872613.1"
                     /sec_met_domain="phytoene_synt (E-value: 2.5e-57, bitscore:
                     193.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3e-68,
                     bitscore: 229.4, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGSPHASAPVLAAYRYCEAVTGHQARNFAYGIRLLPTEKRHAMS
                     ALYAFSRRVDDIGDGPLDPEEKRTRLADTRALLDRMRSGGIEEDDTDPVAVAVSHAAHR
                     FPIPLDALDELIDGVLMDVAGQTYETWDDLKVYCRCVAGAIGRLSLGVFGTAPGTGHSE
                     DELERAPYYADTLGLALQLTNILRDVREDAATGRTYLPADDLAKFGCATAFRSSTAPPD
                     ADFTGLVHFEVRRARALFAEGFRLLPLLDRRSGACVSAMAGIYRRLLDRIAKDPAAVLR
                     GRVSLPGHEKAYVAVRGLAGLDARAVERRGTGRAV"
     gene            complement(15591..16454)
                     /gene="hpnC"
                     /locus_tag="CFP59_RS11485"
                     /old_locus_tag="CFP59_02270"
     CDS             complement(15591..16454)
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088373.1"
                     /locus_tag="CFP59_RS11485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02270"
                     /product="squalene synthase HpnC"
                     /protein_id="WP_100805694.1"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.4e-39,
                     bitscore: 135.2, seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="phytoene_synt (E-value: 7.8e-39, bitscore:
                     132.6, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDKAAHENFPVAPFFLPRAWRTDLMAVYGYARLVDDIGDGDLAP
                     GGADAELLGLDRDRADDALAMLDAFEADLHRVFRPAGEPRHPLLRALRPTVHRHGLTPE
                     PFLGLIEANRQDQSVRRYATYQDLLGYCELSANPVGRLVLGITGTTSPERIRHSDAICT
                     ALQIIEHVQDVAEDLRRDRIYLPAEDMKRFGVTEADLAAPRGGVRLRALVAKEAERAAA
                     LLNEGTPLVGSVHGRLKVLLAGFVAGGQAALRAVAAAGHDVLPGPPRPTKLSLLREVGA
                     TLRREG"
     gene            complement(16895..17635)
                     /locus_tag="CFP59_RS11490"
                     /old_locus_tag="CFP59_02271"
     CDS             complement(16895..17635)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056063.1"
                     /locus_tag="CFP59_RS11490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02271"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_069872380.1"
                     /transl_table=11
                     /translation="MSPGEAHVAPYSRRERLRIATIREIKDVARTLLVQEGPENVTIRA
                     IAREMGMTAPAVYRYFSSRDALILQLRVDIFEEMARFMRGVLGQHPEEEPGRRWISGAR
                     ALRVWAIKHPHEFGLILGPWAPGLGREETKPERHMSWVFGSVFSDLVADLWRVRGFPAP
                     EVEELDPGLARTLTVLSEDQDVDMPPGAIAVMLRCWVRLYGVISMEALGHMSFALSEGQ
                     HFFEFELRDLCRVLDISEFYEEVV"
     misc_feature    complement(17848..17863)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.74"
                     /tool="antismash"
     misc_feature    complement(18677..18693)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.03"
                     /tool="antismash"
     misc_feature    18752..18767
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.89"
                     /tool="antismash"
     misc_feature    complement(18752..18769)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.78"
                     /tool="antismash"
     gene            complement(18833..19507)
                     /locus_tag="CFP59_RS11495"
                     /old_locus_tag="CFP59_02273"
     CDS             complement(18833..19507)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024950.4"
                     /locus_tag="CFP59_RS11495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02273"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_269462897.1"
                     /transl_table=11
                     /translation="MSGCIEEASMAEVREQFETNVYGLVRLSQLVLPGMRAHGGCTIVN
                     VSSISGRYAVPGSGFYNATKHAVEALSDSLRNEVADFGVRVVLVEPGPVRTTRFGATYV
                     ANLRPVSRTYETFRRESAEYFEAIYTGSRRTLAGSFAIQPDDVARRVARVVAKGVRGGR
                     ARARYPVGQSPPTRRAIKERPRMAYLPFGSGPVTACERGTAVPRPPRRTAPAESAACPH
                     RP"
     gene            complement(19801..20652)
                     /locus_tag="CFP59_RS11505"
                     /old_locus_tag="CFP59_02274"
     CDS             complement(19801..20652)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056053.1"
                     /locus_tag="CFP59_RS11505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02274"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_069872388.1"
                     /transl_table=11
                     /translation="MAEQTLDKGAKAAQAEQAGKAEQAAQAASARSRVPTVVADDVHIV
                     YRVNGGPKGKGSATAALSRILRRKGAPGMREVHAVRGVTFVAYKGESIGLIGSNGSGKS
                     TLLKAVAGLLPTERGKVYTDGQPSLLGVNAALMNDLTGERNVILGGLAMGMSREQIRDR
                     YQDIVDFSGINEKGDFITLPMRTYSSGMAARLRFSIAAAKDHDVLMIDEALATGDRKFQ
                     KRSEARIRELRQEAGTVFLVSHNNKSIRDTCDRVLWLEKGELLMDGPTDEVIKAYEKET
                     GK"
     gene            complement(20645..21580)
                     /locus_tag="CFP59_RS11510"
                     /old_locus_tag="CFP59_02275"
     CDS             complement(20645..21580)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972239.1"
                     /locus_tag="CFP59_RS11510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02275"
                     /product="ABC transporter permease"
                     /protein_id="WP_079153686.1"
                     /transl_table=11
                     /translation="MSETTHDGAVAVSGPPSADDGLSPAELAQKYGLSVSGARVGLREY
                     INQMWGRRHFIVAFSSAKLTAQYSQAKLGQVWQVATPLLNAAVYFFIFGLLLKSSRGMP
                     NDMYIPFLVTGVFVFTFTQASAMAGVRAISGNLGLVRALHFPRASLPISFSLQQLQQLL
                     FSMIVLVVVLLGFGHYPAFSWLLILPTLALQFVFNTGLSLIMARLGAKTPDLAQLLPFI
                     LRTWMYASGVMFPLARTLEHAGASKWISDAMLGNPAAVYMDLMRYALIDDYTAANLPPH
                     VWALALGWAVLFGAGGFVYFWKAEEQYGRG"
     misc_feature    complement(21574..21592)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.82"
                     /tool="antismash"
     gene            complement(21660..22532)
                     /locus_tag="CFP59_RS11515"
                     /old_locus_tag="CFP59_02276"
     CDS             complement(21660..22532)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031159.1"
                     /locus_tag="CFP59_RS11515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02276"
                     /product="glycosyltransferase"
                     /protein_id="WP_069872392.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.7e-09,
                     bitscore: 35.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVGAVVLTMGNRPEELRALLDSVAKQDGDPVEAVVVGNGSPLPP
                     LPEGVRTVELPENVGIPAGRNVGIEAFGPGGSDVDVLLFLDDDGLLPGTDTAELCRAAF
                     AADPGLGIISFRIADPDTGVTQRRHVPRLRASDPLRSSRVTTFLGGANAVRTAVFQQVG
                     GLPDDFFYAHEETDLAWRALDAGWMIDYRSDMVLHHPTTAPSRHAVYHRMVARNRVWLA
                     RRNLPALLVPVYLGVWLLLTLARRPSKTALRAWFGGFREGWKTPCGPRRPMKWRTVWRL
                     TRLGRPPVI"
     gene            complement(22544..23335)
                     /locus_tag="CFP59_RS11520"
                     /old_locus_tag="CFP59_02277"
     CDS             complement(22544..23335)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008413838.1"
                     /locus_tag="CFP59_RS11520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02277"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_079259576.1"
                     /transl_table=11
                     /translation="MPKQSVKPSVAELRPVVHPEGVKDRRSGEHWAGRLYMREISLRCD
                     RYLVNTRVTPNQLTYLMTVFGVLAAPALLVPGIAGAVLGVLMVQLYLLLDCVDGEIARW
                     KKQFSLGGVYLDRVGAYLCDAAVLVGFGLRAADLWGSGRIDWLWAFLGTLAALGAILIK
                     AETDLVGVARHQGGLPPVKEAASEPRSSGVALARRAAAALKFHRLVLGIEASLLILVLA
                     VVDQVRGDLFFTRLGVAVLAGIALLQTLLHLVSILASSRLK"
     gene            complement(23301..24374)
                     /locus_tag="CFP59_RS11525"
                     /old_locus_tag="CFP59_02278"
     CDS             complement(23301..24374)
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1181: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056049.1"
                     /locus_tag="CFP59_RS11525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02278"
                     /product="iron-containing alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_069872399.1"
                     /sec_met_domain="Fe-ADH (E-value: 7.4e-23, bitscore: 80.0,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVLTRLIPSPLVVDIRAGALDDLAGVLADQRISASGKLAIAISG
                     GSGAVLRERLAPALPGASWYEVGGGTLDDAIKLADRMKSGHYDAVVGLGGGKIIDCAKF
                     AAARIGLPLVAVATNLSHDGLCSPVATLDNDAGRGSYGVPNPIAVVIDLDVIREAPVRF
                     VRSGIGDALSNVSAVADWELSHRETGEQIDGLAAAMARQAGEAVLRHPGGVGDDGFLQV
                     LAEGLVLTGISMSVAGDSRPASGACHEINHAFDLLFPKRAASHGEQCGLAAAFAMRLRG
                     AHEESEHMAEVLHRHGLPVLPEEIGFTVDEFVQVVEFAPKTRPGRYTILEHLDLSTDAI
                     RDAYADYAKAVSQTISG"
     gene            complement(24362..25114)
                     /locus_tag="CFP59_RS11530"
                     /old_locus_tag="CFP59_02279"
     CDS             complement(24362..25114)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983099.1"
                     /locus_tag="CFP59_RS11530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_02279"
                     /product="phosphocholine cytidylyltransferase family
                     protein"
                     /protein_id="WP_069872403.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.1e-09, bitscore:
                     37.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGLVLAAGAGRRLRPYTDTLPKALVPVGPEGKEDETTVLDLTLG
                     NFAEIGLTEVAIVVGYRKEAVYERKEALERKYGVKLTLIDNDKAEEWNNAYSLWCARDA
                     IQHSVILANGDTVHPVSVEKTLLAARGNGQKIILALDTVKQLADEEMKVVADPDKGVQK
                     ITKLMDPAEATGEYIGVTLIEGEAAADLADALKTTFERDPDLYYEDGYQELVNRGFKVD
                     VAPIGDVKWVEIDNHDDLAKGREIACLY"
     misc_feature    complement(26004..26018)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.39"
                     /tool="antismash"
ORIGIN
        1 tagggcgcgg cggcatcgtg gtcgctccgc cccgccacga cgtgtttcgt cttccggcgc
       61 tgagcacgtc cgtcggcgag gcgagaaggc atgtcgtccg gcggctgcgc tcatggggca
      121 tcgaccagga caccctggac agcgccgagt tgatcgtctc cgagctgttc accaacgcgg
      181 tgcgccacac ctccagcgag gaggttcgct gctcgctcca gctcataggc acccggctgc
      241 ggctcgaagt ggccgaccag gggtgcgcgc gcacggtgcc ggaggcccgc tcggtgagcg
      301 cggaccagga gggcggccgt gggctgatgc tggtggaggc cctctccgag gcatgggggg
      361 tcaggccgaa ccaggggggc gccggccgag cggtctgggc gtatctggcg gtctcggtct
      421 agcggtacgg cgacgacgcg acgtacgagc ggtgccgagg gaataggggc agcgacagcg
      481 caccaggtgg tcgaccgcgg ggcgccaacg ggggtctgcc cctattcctc cgggaccgct
      541 tcgggtcacg gaacgttcag tgccgcagcg gcagcagatt gggccgcttg ggctccacat
      601 ggtcacccga cgactctccg cgcagtcgtc ggccgatcca gggcaccaga tattcgcgcg
      661 cccagtggat gttgtcccgg cgcacctcgg ccgcggtgcg ctggccctcc gggggccagg
      721 gctgatcggg gtcggcgggg acgtcgagcc ccagcacctg accggccctc agcgcgaccc
      781 gggtgtgacc gtccggcgac agatgcagcc ggtcggcgtc ccaggcccgg cggtcctgca
      841 ccgagcgcag cgaccacagg tcgagcaccg ggcagccatg gcggtcggcg atcgcccgca
      901 catgcgccgt atacgtggcg atcttgcccc gtagatggcg cagcaccggc acccctctgg
      961 tgtcgaagcc cgtgcacagc agcaccgtgc ccaccctcgc ccggaggtcg gcgacggccg
     1021 cctcatagcg ctcggcgaca tcgtcggggt cgctgccggg ccgcaggatg tcattgccgc
     1081 ccgcacagaa ggtgaccaga tccgggccga gttcaatggc gcgccgcacc tgctccgcca
     1141 caatctggtc aaggagtcga ccgcgtacgg ccagattggc gtagcggaaa tcgtcttggg
     1201 gtcgttggtc ggacagcagg accgcgagcc ggtcggccca gccgacgaac accccatcag
     1261 gaccggggtc gccgacgccc tcggtgaagc tgtcgccgac ggctgcgtac gacccgatgg
     1321 aaccgttgct gaatctctcc ttatcgtctg ccacgtcggg acatcattca cccgatggcg
     1381 tgacttacgc caccgtaacc agggcttgac gtggggtgat ctatcccacc tggtcagttt
     1441 cggcaaaggc ggaataggca gagcgcggcg gcgccgaggt cgccggaggt ccacagccgg
     1501 tcggtcgggc cggcatgccc ggatcgatcc gggcaccacc cccgagcagg gccggaaggc
     1561 cacccgatgc ccgcgttccc gcgaggccga ttgcctgttg cacccatgtc gtagggtcag
     1621 cttcagccgc ctgtcgacga gccgcgtcgg cggccgatcg tgaaggagag cccgtgccgc
     1681 agcagtcaca gtcgccgcag gtcccccagg ccgaaacacc cctggtgggg gtacgcaact
     1741 tccgtgatct cggtggactg ccggctgccg acggccgccg cgtacgcccg ggtgtgctgt
     1801 tccgcagcgg ccatctcgcc catgccacgg aggcggacac ggccttcctc gacgcgctcg
     1861 gactgcacac gatcttcgac ttccgcaacg ccgccgacat caagctggag ggcccggacg
     1921 tcacgctccg cggggtccgg aacgtcaatc tgccgctgtc cgacccggcc gatggcgccg
     1981 ggttctggac gatggtgcgc gagggcgatc tgaagaccct gcgcgagctg ctctccgagg
     2041 gccgggccga gaagcgcatg atcggctcct atcgctccat catcaccacc cggctggtcg
     2101 agcacggccg gatcctcagc gatatggcgg aggacagctc accggtgctg atgcactgtt
     2161 cggccggaaa ggaccgggcc ggcctgtcca tcgcggtgac cctgctggcc ctcggagtcg
     2221 accaggagac catcgaggcc gactacctcg aatcggccgc cgcccaccgc cgctacaaga
     2281 tctggcgcaa gggcgatcct tcggacagct ccgaccccat gtcccccgag gtcatggcgc
     2341 tgctgctgcc gctcttcgac gcccgcgcgg aatatctggc ggcggccttc gcgaccatcg
     2401 aggagacctg gggcggcacc gagcgctatc tcgccgaggg gctcggcctc gaccccgagc
     2461 ggcgcgagcg gctgcgggag cggctgctca ccggctgacg gcgcgcccgt gagcaggtga
     2521 gcccgtaggg ccctggagcc ctactggctc accatatggt ggcgggcccg gcctcgggct
     2581 cggtgaccca ccccgccgtc agcaccagac cgctggcgcg gtgcacggcc aggaagccga
     2641 acggccgctc gtaccgcaca ctgatcagct tggccgggcg ccgcggcggt accgagccgg
     2701 gggccaggga gaacgcggtc accgccgccg cccagaagcc ctccgcgctg aacgaggcgg
     2761 tgatggactg ctctccggag gagagcgcca gcgcggcggg gctgatcccc gggaagtggc
     2821 cgcgcgaggc gtcctgggcg gtgcgcagcc cgaacagccc ggccctgcgc agcagatcgt
     2881 gccgcgcctg cacggtgaac cgcggagcgg tgagcgccat ccggggcgtg gggtcccggc
     2941 tcgggacctc catgacccgg accccgggcc ccgcctcacc gggcggcagc gccgagccgg
     3001 gccgcccctc gtaccgcccg gccaccgcgc cgatcccggc ctccagcacc tcgccgccgg
     3061 gaacgccgtc ggcgccgagg accaggcgca catccagtcc gttgccgccc gcgaccccgg
     3121 agagggtgag cgggccggcc ggggtgtcgg ggacgacccg cagcgccccg tcgaggtcct
     3181 ccgtgaaccg ggtgagcccg gccagcgacc ggtcccgcca cggtccgctc ctcggcacca
     3241 gcgggcccgg ctggaacggc tgtacccagt cggtccgcac cgtgagcgct ccggccagca
     3301 ccagcagggt ggcgggggtg agcggcaccg gcatctcggt gatcgcgccc cgggtgcgcc
     3361 gggacgccca ggcgtccagc tccttgcggt cgcgttcacc gtccccggtc agcgtggcgc
     3421 gtacgcccgg cggcagcgcg gcctcccacc ctgaccggat cggcaggtcc cggcgggtcc
     3481 acagcccggt ggccgcatcg acgccggcca tgccgtccag cgccccgagc acctctccgc
     3541 cgagcgccgt cgccgcgtcc gcgccgacgc ccagcgcgcc ctccagctcc tggcggacgg
     3601 ggccgccggc accgcccgcg agcagggcca gcagcggcca gaccccggcg gcggcgagga
     3661 ccgtgccctc gtccgtcacg gccgcccgcg cccacctcgc cgtcatcgcg ttgacggccc
     3721 gtacggcggt cgcgtcgatc atgccggtcc cccaacggtc agcggttggc caccgcctgt
     3781 ttgacgagag tgcggccgaa ctcccacatc aggccgccgc cctcgtgcgc gtcgtccatg
     3841 accgctgtga acgcctcgac gaaacggtcc acttcccgct cgccgatgat cagcggcgga
     3901 atcagcttaa tgacctccag atggtcgccg gagacctggg tgaggatgcg atggcggcgc
     3961 agcagcggta cgacgaccat ctgcgcgaac agccccttgc gcgcggtctg gagcatcgcc
     4021 caccggctgc gcagccccag tgagctgggt cggccgaact cgatgccgat catcagcccc
     4081 cggccgcgga cgtcgtgcag cagctcgtag cggtccacga gcgcggcgag gcggtcgcgc
     4141 agcagctcac cggtgcggcg ggcgttggcc accacctcct cgtcctccat gacggcgagg
     4201 accgcgagcc cggccgccat ggcctgggca ttggagccga agctggcgga gtggaccagc
     4261 acccggtcca tcgaggagta gacccgtctg aagatccagt ccttgccgag ggtcgcgccg
     4321 accggcacat agcccccgga gagtgccttg gccacgcaca ccagatccgg ttcgacaccg
     4381 tcctcgtgct ggtaggcgaa gaagtccccg gtgcggccga ggccggtctg cacctcgtcc
     4441 acgatgagca gggccttgtg gcggtggagc agctcctgcg cggcgcgcag gaagccgggc
     4501 ggggtctcgt gcaccccctt gccctggatg ggctccacca cgaaccccgc cacgtccccg
     4561 cgcgccagct cccgctccag cgcggcgagg tcgcccatct cgatcgcggt gtcgggcagc
     4621 agcggggcga accccttgcg gaagccgtcc tcgccgttga ccgacagcga gccggtggtc
     4681 agcccgtgga aggcgtgggc gcagtacagg acgcgcggct tgccggtcac gaagcgggcg
     4741 aacttcaggg cggtctcgac ggcctcggtg ccgctgttgc cgaagaagac ccggtccaga
     4801 tggggggcgt gggccagcag ccgctcggcc agcagaccgg gcagcggctg gcagtcgaaa
     4861 cgggtcagat cggccaggtc ggcgtccagg acgtcgtgca gcgccttgcg gaccacgggg
     4921 tggtggcggc ccaggcccat caccccgaag ccggcgagca tatcgaggta gtcctggccc
     4981 tcgtcgtccc agaagtacgc gccctcggcc cgttcgtaga ccttgtcgaa gccgatggtg
     5041 tgcagcatcc ggggcagctg gtggttgagg tgccgggtgt gcaggtcgta ccgctccgac
     5101 gcccgctcgg ccaggagctt gcccaggtcg aagcccgaac gccgctgctg ctcggctgct
     5161 gtcatgcctg gctctccttg gcggctgcgg tacggccccc ggcggcggta cgggccccgg
     5221 cagtggcgcc cgcccgctcc gggcgggccg cgtcgatacg ggtcagggcc gccccgatcc
     5281 ggcccgcgat ctcggcgggg gtgagcccga tgtcggcgag cacctcaccg cgcttggcat
     5341 gggccaggaa cgcctcgggg atgccgaacg tccgcaccgg caggtcgacc tcggcgtcac
     5401 acagggtctg ggcgaccgcc gcgcccaccc cgccggtgcg cacattgtcc tcgacgaccg
     5461 ccaccagccg gtggcgcgcg gcaagtccgg gcagctcggg gtcgacgggc ttgacccagc
     5521 gcggatcgac caccgtacag ccgatgccgc gcccggccag cagctcggcg gcgcgcagcg
     5581 cgacgtcggc catcaccccg gccgcgacga ggaggacatc ctcgccccgg cgcagcacat
     5641 ccatcccgcc gacgcggtcg atcgccggaa tcggctcccc caccgactcc ttggggaagc
     5701 ggatgacggt cggcgcgtcg gccacgtcga tcgcctcccg cagctgggcg cggagctggt
     5761 cggcgtcgcg cggggcggcg atccgcagcc ccggcaccac ctggaggacg gacatgtccc
     5821 acatgccgtt gtggctgggc ccgtcggtgc cggtgacacc ggcccggtcc agcacgaagg
     5881 tcaccccgca tctgtgcagg gcgacatcca tgagcagctg gtcgaaggcg cggttgagga
     5941 aggtggcgta gacggcgagg accgggtgga gtccgccggt ggcgagcccg gccgccgaga
     6001 ccgccgcgtg ctgttcggcg atgcccacgt cccacacccg ctccgggtac gcctcggcga
     6061 agccggcgag gcccacgggg tgcaacatgg cggcggtgag ggcgaccaca tcgggccgct
     6121 cggcgccgat ccgcaccatc tcctcgccga acaccgaggt ccacgagcga ccgccggagg
     6181 gggccagcgg cgcgcaggtg agcgggtcca tcgcggcgac ggtgtggaaa cgatccgcct
     6241 cgtcctccag cgcgggccgg tagccccggc ccttctcggt gaggcagtgg acgaggaccg
     6301 ggccgtggaa ccgcttggcg cggcgcagcg ccgactcgac cgcctcggtg tcatggccgt
     6361 cgatggggcc gacgtacttc agcccgaggt cctcgaacat gccctgcggc gcgaaggcgt
     6421 ccttgaaccc cttcttggcg ccgtgcagcg atccgtacag cggctggccg accacggggg
     6481 tgcgctggag cacctccttg ccccaggcca ggaagcgctc atagccgtcg gtggtgcgga
     6541 gggtggcgag gtggttggcg agtccgccga tggtcggcga gtaggagcgc tcgttgtcgt
     6601 tgacgacgat gacgaggggg cggtcccggg cggcggcgat gttgttgagc gcctcccagg
     6661 ccatcccgcc ggtcagcgcc ccgtccccga tgacggcgac cacatggtcc gtgccaccgc
     6721 gcacctcgtt ggccttggcg aggccgtcgg cccagcccag cacggtggag gcatggctgt
     6781 tctcgatgat gtcgtgctcg gattcggccc gtgacggata gccggacagc ccgcccttgt
     6841 ggcggagctt ggagaagtcc tgacggccgg tgagcagctt gtggacgtag gactggtgcc
     6901 cggtgtccca caggatgcgg tcggcgggcg agtcgaagac gcggtgcagg gctatggaca
     6961 gctcgacgac gccgaggttc ggtcccagat ggcccccggt cctggccacc gctttgatca
     7021 ggaactccct gatctcctgg gcgagcgcct ccagttcctc atcggtgagc gccttgaggt
     7081 cgtgcgggcc ccggatgttc tccagaaacg gcatggtcgg ttcccctcct cggtgtatca
     7141 gcccacggtg acgtccgggg tgcccgacgg gaccccctcg tcctccatgc gccgcgcgat
     7201 gttcatggcc tcgtcgatca gggtctccac gatcttcgac tccggcacgg tcttgatgac
     7261 ctcgcccttg acgaagatct gccccttgcc attgccggag gcaacaccca gatcagcctc
     7321 ccgcgcctca ccggggccat tgaccacaca ccccatgacc gccacccgca gcggaacctc
     7381 cataccctcc agacccgccg tcacctgatc cgccagcttg tacacatcca cctgcgcccg
     7441 cccacacgac ggacacgaaa caatctccaa ccgccgctgc cgcaggttca acgactccag
     7501 aatctgcatc ccgaccttca cctcctccgc aggaggcgcc gacaacgaca cccggatcgt
     7561 gtccccgatc ccctcactca gcagcgcacc gaacgccacc gccgacttga tcgtcccctg
     7621 gaacgccgga cccgcctccg tcacacccag atgcaacggg taatcacact gcgccgccaa
     7681 ctgacggtac gcattgacca tcaccaccgg atcgttgtgc ttcaccgaga tcttgatatc
     7741 ccggaaccca tgctcctcga acagcgagca ctcccacaac gccgactcca ccaacgcctc
     7801 cggagtcgcc ttcccatact tctccagcaa ccgcctgtcc aacgaccccg cgttcacccc
     7861 gatacgaatc ggcacacccg catccgacgc cgcccgcgcg atctccctca ccttgtcatc
     7921 gaactgccgg atgttccccg gattcacccg caccgccgca cacccggcat caatcgccgc
     7981 aaacacatac ttcggctgaa aatgaatgtc ggcaatgacc ggaatctgcg acttcttcgc
     8041 aatcaccggc aacgcatccg catcatcctg cgaaggacac gccacccgca caatctgaca
     8101 ccccgacgcc gtcaactccg cgatctgctg caacgtcgca ccgacatccg cagtcaccgt
     8161 cgtcgtcatc gactgcaccg agaccggcgc atcgccaccc acggccaccg accccacctg
     8221 gatccggcgc gagacccggc gcggcgcgag cggcctgtcc ggcatggcgg gcaggccgag
     8281 tgcgattggt tccgctgaac tcatcgagtc accttttgct tccggcggcg gtttcacggg
     8341 cggcgcgcag cgactccttg agggagccca tggtcgccag gaccgcggtg ggctcatagc
     8401 cgcagtgggc catgcagttg tcacagcgcg ggtccttgcc gcggccgtac ttgtcccagt
     8461 cggtctcctc gaccagctgg cggtaggtcg ggacatagcc gtcgctcatc aggtagcagg
     8521 gtcgctgcca gccgaagagg gagtagttgg gaatgcccca ggcggtgcac gggaagtccg
     8581 tcttgccttc gaggaagtcg aggaagagcg ggctgtggtt gagccgccat cggcggcggt
     8641 tgcctccggc gaacgccttc cggaacagct cgcgggtctg ctccacgccc aggaagtgct
     8701 cctggtcggg cgccttctca taggcgtagg cgggcgagat catcatctcg tccacctcga
     8761 gctcgtcatt gaggaagtcg aggacgtcca cgatggtctg gggggtgtcg gtattgaaga
     8821 aggtggaatt ggtggtgacc cggaagccgc gccgcttggc ctccttgatg gcctccaccg
     8881 cctcgtcgaa caccccctcc ttcgcgaccg attcgtcatg ccgctcccgc agcccgtcga
     8941 tgtgcaccgc gaaggcgaag tacggggagg gggtgaacag atgcatcttc ttccgcaaca
     9001 gcatcgcgtt ggtgcacagg aagacatact tcttccgttc caccagctgc cgtgcgatct
     9061 cgtcgatctg cggatgcatc aggggttcac cgcccgcgat ggacaccatc ggggcacccg
     9121 actccagcac cgcgcccacc gcctgggcga ccggcatgcg ctgcttgagg accccggccg
     9181 gatgctggat ctttccgcag ccctcgcatt tgagattgca cgcgaagagc ggctcgagct
     9241 cgacgatcag cgggaacttg tcccgccgtt tgatcatctt ctgttcaaag agatacgtcg
     9301 cgacccggat ggtctggcgg agaggcatgg ccatctagct cacctcctgg gagcagcgaa
     9361 gaacggtgcc agtgaaagaa agcgggaaga acggttcgta gaacccggaa agccgatatt
     9421 ccaccgcgca gggtgccaat tcggacgagt tcatgttcag gagcgtccac gaccacccgg
     9481 acggccgcaa ccggacggac gccgtggccg acggcggtgc gcagggtcgc ggcggactcc
     9541 atgtccaccg cgatggctcc ggtgcggtgc agcgcggtcc gctccgcacc gcgcaccaca
     9601 tggtcggagc ccacgaccgg gccgatgtgc acggcacggc gggggccgcc cggaagcggc
     9661 cgtgacaggg cgtcggcgag gatccgggtg ccggtgcaca cggtgcggcc cgccggatcg
     9721 cgggtctcgt cggcgacgac gaggtccccc gggtgcatcc cgggggccag cccggcgcag
     9781 aagccggtgg cgatgacggc ggtgcgccac tccccggacc cggcggtcag cgcccgggtc
     9841 acggcgcgct cggccgactg cggccccata ccggtgcgca ccacggtcac ctccccggcg
     9901 gcgccggggc cggcgccgcg cagggcgaac cgctcgatgc cgagcgcgca ggcgatcagc
     9961 agcggcgcac caccggcctc cggggccgga tcggcggaca tcaactgctc cgcggtcgcg
    10021 ccccggtggg ctcgccgtgg acaaaccggc cgagtgccgt gaccgggaag acctgacggt
    10081 acaggtggta gttgatggag aagtcccagg ggaaaccggt gccggtgaag tacggctcgt
    10141 cccaggagcc gtcctcccgc tgggtctcgg cgagccaggt gaccccgcgc tcgacggccg
    10201 cgccgccccc ctcacccgcc gcgagcagcg cgagcagcgc ccacgcggtc tgggaggcgg
    10261 tggaggcgcc ccggcccatc cactcggcgt cgaggtagga gcgctggtcc tcgccccagc
    10321 cgccgtcctc gttctggacg ctctccagcc agcggacggc ccggcggacc gccggatggg
    10381 aggcggggac acccgcggag atcagcgcgg ggacgaccga gccggtgccg tagacgtagt
    10441 tggtgcccca gcggccgaac caggcgccgc tcggctcctg ctcggacagc agccaggaga
    10501 taccgcgccg ggtgcgggcg tcgtacgtcc tgccctcgtg tgcgagcatc tccacgacat
    10561 gcgcggtgac atcggccgac ggcgggtcca cgacctcgcc gaagtcgcag aacggcagct
    10621 tgttgggcag cgggctggtg ttgtcgacgt cgaacgcgcc ccacgccccg ttcttggact
    10681 gcatgcccag ggtccagcgc atggcgcgcc gcacggccgc ctcgatccgc gcgggctcgg
    10741 ggtggtcgac ccggcgcagc gccaggatga cctcggcggt gtcgtcgata tcggggtagt
    10801 tgtcgttgtg gaattcgaac gcccagccgc cggagggcag ccccggccgc cggaccgacc
    10861 agtcgccggg ccggtcgatc tgctcggcca tcatccagtc ggcggccttg accagcgccg
    10921 gatggtccgg ggcgagtccg gcatcggcga gcgcgatggc ggccagacag gtgtcccaga
    10981 ccggggactg acaggcttcg atcatccggc tgccgtcctc gcgccacacc gcgaaccggt
    11041 cgagcgactc cagaccggcg cgcatcacgg ggtggtcgag gtcgtagccg agcagatgga
    11101 gggcgatgac ggagtagacg gcgggtggct ggataccgcc ccagcagccg tcgttctcct
    11161 gccgctccac gatccagcgg gcgcaggagc gcagcgcgga ccggcgcagc gggcggaggg
    11221 cgaccttgtg gtaggcgtgc agcgcccggt ccagccgctg gaagacgccg tcccaggtgg
    11281 cgatgggggc ctgcggaagc ggcggattgg gcttgcgggg gtcggtgtgg agctcgtcga
    11341 gggggaaggg ggccgggcgc acggggcgtt tggccgagac gacggtgagg ggcacgatgg
    11401 tctgccgggc ccagcagccg aagtcgtaga tgttgagcgg aaaccacttc gggaagtaga
    11461 tgatctccgg tggcagctcg ggcaggtcct cccagcgcca ccagccgaag agggccagcc
    11521 agatccgggt gaacaccctg ctggccgcga cgccgccccg ggagcgcacc caggcggagg
    11581 cggcggtcat atggggcgcg tcgggctcgt cgccggccag ccgcagggcg acataggcct
    11641 cgatggtggt ggagagctcg ggcgggccgc cgtggaaggt ggcccaggtg ccgtcggggg
    11701 cctgctggga gcgcagatag cgggcggcgg cgtcgagggt gtcggggtcc tggatgccga
    11761 ggaactgccg gagcatcaga tcctcggcgt ccatggtgac gttggtctcc aggtcgccct
    11821 tccaccagcc gcgctcgtcc tggcgggaca gcaggtgctc caccgcgcgg gccgtcgcct
    11881 cacgggcgac gctcaaggtc ttggactcgg atgactcgga gggttggacg gtcggtgtcg
    11941 ctgtcatggc ttcccctcgc agtgtgttca tctgccgtct ttggggcttc cgtcggccga
    12001 caccccggct gggtgccggc cggcgactgc gaacgcgaac tagcggtcca tggcgatcat
    12061 ctctttcgta cgacgacgaa gtcggcgagc gccacgaacc gggcccggat ctcggcgggc
    12121 atgtccaccg agcccagcgc ctccatggcg gtcgcatgct gtctgcgggc ctcctgagag
    12181 gtccagtccc ggccacccgc ttgttcgatc aacgcggcgc ggacggcgaa ttcttcctcc
    12241 gagaagtccg cgaactcctc ctccggcttg cgcgcgtcgg ccgcgaggat ctgggccagg
    12301 cgctcggagt cggggccgcc ggcggcgagc gcggcgacca ccggcaggga cttcttgcgc
    12361 tggcgcagat cgctccaggt ccgcttgccg gtggcctccg ggttgcccca gatgccgagc
    12421 aggtcgtcga cggcctggaa ggcgaggccc aggtggtggc cgtagcgctc caggatgtcg
    12481 gcggtgcggt cgtcggcgcc gccgagcacg gcgccgatgg aggccgcgca ggcgagcagg
    12541 gcaccggtct tgttgccctc catctccagg cactcctcga cggtgacccg ctcgcggtgt
    12601 tcgaaggaga tgtcctgggc ctggccgtcg atcagtttcc gggtcgccgc ggtgagccgg
    12661 cgggtggccc gcccggcctc cacggtgccg atctccagca gtatctcgtt ggccagggcg
    12721 aacagggcgt caccgaccag gatggcctgg gccgggccat gctccttcca caccgtgttg
    12781 cggtggcggc gctgctcgtc cccgtccatc aggtcgtcat ggagcagcga gaagttgtgc
    12841 accagctcga ccgcgaccgc gccgggcacc ccggcctcgg gggcggcgcc cgccgcctcg
    12901 gcggacagca gggcgagcgc ggggcgcacg gccttgccgc cgtcgccctc cgccgggttg
    12961 ccctcggcgt cgatccagcc gaagtggtac gcggcgacgg tgttcatggg cggagccaac
    13021 cggtgcacgg cggcgcgcag caccggcgtg gcgagcgtgc ggccgcgctc cagcagcggc
    13081 atgacgcctg cggtgtcggc agctggggtc gccgaggtca cggtctctcc tctgtttttg
    13141 gtggtggtgc tcatgccacc tccttgggcg tccccccgcc gagggcgggg agagggttca
    13201 catgtgggcg gccgaggtcg gtgagggcgg tgcgggctgc ggaaagaccg ctgcgcacgg
    13261 cgccctccat ggtcgcgggc cagccggtgg cggtccacgc accggccagg tagaggccgg
    13321 gcgcgtcggt cggggcggag ggccgcagga ggccgacgcc ggggacgggc gcgaaggtgg
    13381 cggtgcgctc ccgggtgacg aagaagtccc tcacccgggc accgcgggcg accggaagca
    13441 gccgctccag ctcgggcaga tagcgggcgc gcagctcggc caccgggcgg tcgatgtcgt
    13501 cgtacgcggc ggactgcgac accgccaggt actggctgtc cccggccccg ggcgcgtccc
    13561 tcagccccga ggcgtccgta cggtcgaaga cccactggac gggcgagccg atcgcggcga
    13621 agaacggacg gcgcagcacc gtgcggtcgt agatcacatg cagattgagg atgggcgcgg
    13681 agccgatgcg cagcagccgg ccggggtcct tcagggcgcc gtcgggcagc agggcgtgcg
    13741 cctcgcgctg cggtacggcc agcacgagaa cgtcggcctc gaccggcgag ccgtccgccg
    13801 gccgcccggc ggtggcggcg ctccagcggc cctcgggggt gcgggtgacg ccggtcaccc
    13861 gggtgcgcag ctcggtcgtc acgcccgccg cgtccagggc gcggcgggcg tgggtgtggt
    13921 gcagctcgcc gagcggggcg cgggcccagc cgatatcggc ggcgccgggc cgggagagca
    13981 gcccggtctt gaagaccatc gcggccaggc cgagcgaggc gttggaggcg gtggcgttga
    14041 gcgtggccac gccgaccagg tcccacagcg cctcgacggc gcgcggcgac tggccgtggc
    14101 ggcgcagcca gccggcgaag tccaccccgt ccagctccgg gtcccggggg tcgagccgcc
    14161 ccagggcgag cgcggcacgg cccacctggg cgcgctcggc gagggagaga tgggggtagg
    14221 tggccaggct cgcggacaga tggagcggca ccggcagggc ggtgcggcgc agccggccga
    14281 gccgccgccc gctccgcccc cgggcgtcca gaacggggac gtccaaccgg ccctggagcg
    14341 gggcgagtcg ggcagcgccg acccgctcca ggaaccactg gtaggcgtcg cagcagcgca
    14401 ggtacacatg ctggccgttg tcgacgctca gcacgcccgc cggggaggag cggtggaagg
    14461 agaaggcgag gccccccagc cggggacgcc cctcgatcag ggtgacccgg agcccggcgt
    14521 cggccagcgc gagcgccgcc gccgtaccgg cgagcccgcc gccgatcacc agcgcggcgc
    14581 gcccgcgggg gcgtggcccg gcgggcgggg cggggtccag ggccgagtgg gtcacaccgc
    14641 cctcccggtg ccgcggcgct cgacggcgcg ggcgtcgaga ccggccagcc cgcgtaccgc
    14701 cacatacgcc ttctcatgtc cgggcagcga gacgcggccg cgcaggacgg ccgcggggtc
    14761 cttggcgatc cggtccagga gtctgcggta gatgcccgcc atggcggaca cacacgcccc
    14821 gctgcgccgg tccagcagcg gcagcagccg gaagccctcg gcgaacaggg ccctggcccg
    14881 gcgcacctcg aagtggacca gaccggtgaa atcggcgtcg ggcggtgcgg tggagctgcg
    14941 gaacgcggtg gcgcagccga atttggccag gtcgtcggcg ggcagatagg tgcgcccggt
    15001 ggcggcgtcc tcgcggacgt cccggaggat gttggtcagc tgaagggcga gcccgagggt
    15061 gtcggcgtag tacggggcac gctcgagctc gtcctcgctg tggccggtgc cgggggcggt
    15121 gccgaagacg ccgagcgaca gccgtccgat ggcgcccgcc acacagcggc agtagacctt
    15181 gaggtcgtcc caggtctcgt aggtctgccc ggccacgtcc atcagcacgc cgtcgatcag
    15241 ctcgtccagc gcgtccagcg ggatcgggaa gcggtgcgcg gcatgggaga cggcgacggc
    15301 gaccgggtcg gtgtcgtcct cctcgatccc gccgctccgc atccggtcca gcagggcacg
    15361 ggtgtccgcc agccgggtgc gcttttcctc cgggtcgagg gggccgtccc cgatgtcgtc
    15421 gacccggcgg gagaaggcgt acagggccga catcgcatgg cgcttctccg tcggcaacag
    15481 cctgatgccg taggcgaagt tgcgggcctg gtggccggtc acggcctcgc agtagcggta
    15541 cgccgcgagt actggcgcgg acgcgtgcgg agatcccttc acggtccggc tcacccctct
    15601 cttcgcagtg tcgcccccac ctcgcgcagc aggctgagct tggtgggcct gggcggtcca
    15661 gggagtacgt catgtcccgc ggccgcgacc gcccgcaagg cggcctgccc cccggccacg
    15721 aatccggcga gcagcacctt gagcctgccg tggacgctac ccaccagggg ggtgccttca
    15781 ttcagcaggg ccgcggcgcg ttccgcctcc ttcgcgacca gggcgcgcaa ccgtacgccg
    15841 cccctggggg cggcgaggtc ggcctcggtc acgccgaagc gtttcatgtc ctcggcgggc
    15901 aggtagatgc ggtccctgcg gaggtcctcg gccacgtcct gcacatgctc gatgatctga
    15961 agggcggtgc agatggcgtc cgagtggcgg atccgctcgg ggctggtggt gccggtgatg
    16021 ccgaggacga gccgcccgac cgggttggcg gacagctcgc agtagccgag gagatcctgg
    16081 taggtggcgt accgccggac gctctggtcc tggcggttgg cctcgatcag gccgaggaag
    16141 ggctcggggg tgagcccatg gcggtggacg gtggggcgca gcgcccgcag cagcgggtgg
    16201 cgcggctccc cggcgggccg gaagacccgg tggaggtcgg cctcgaacgc gtccagcatc
    16261 gcgagcgcgt cgtccgcccg gtcgcggtcg agaccgagca gttcggcgtc ggcgccgccg
    16321 ggggccagat cgccgtcgcc gatgtcgtcg accagccggg cgtagccgta aacggccatc
    16381 agatcggtgc gccaggcgcg ggggaggaag aagggagcca cgggaaagtt ctcgtgggcg
    16441 gccttgtcga gcacggcacg ggcggcttcc tgcccgccgc tccggctgct cgacgtggta
    16501 taggacccgc tgcgctcgtc ctccacgctc accgtggaca gccaggcgta cgggcgagac
    16561 ccaggacgcc acctgggtcc cggcgaccgg gccccgcggg agcgctggag atgggccgtg
    16621 tggccaatgc cgtcacatcc cccgttctac accggttacc agggtcggca cgatccggac
    16681 acgccgctcc gtcttgtcaa cggactccgg ccccgagccc ccgaacaggg gacaagggcc
    16741 cggctccggc atgatccgga caggcattgg cacagcttac gcctctcggt gtacaggtgt
    16801 acggggcgat accccgatgt gacctccgaa gtggcgccgg gcgggtgacc ggcgaacgcc
    16861 cccggaccgg tctccggggg gctttcgggt gacctcagac gacctcttcg tagaactcgg
    16921 agatatccag cacccggcac agatcgcgca gctcgaactc gaagaagtgc tggccctcgg
    16981 agagcgcgaa ggacatatgg cccagcgcct ccatggagat caccccgtac agccgcaccc
    17041 agcagcggag catcacggcg atggctcccg ggggcatgtc gacgtcctgg tcctcgctga
    17101 gcacggtgag cgtgcgcgcg agcccggggt cgagctcctc gacctccggg gcggggaagc
    17161 cccgcacccg ccacagatcg gcgaccagat cggagaagac cgagccgaag acccagctca
    17221 tatggcgctc cggcttggtc tcctcacggc cgagccccgg ggcccatggg ccgaggatca
    17281 gcccgaactc atgggggtgc ttgatcgccc agacccgcag cgcccgggca ccgctgatcc
    17341 accggcggcc cggctcctcc tcgggatgct ggccgaggac cccgcgcatg aaacgggcca
    17401 tctcctcgaa gatgtccaca cgcagctgga ggatcagcgc gtcccggctg ctgaagtagc
    17461 ggtagacggc gggcgcggtc atgcccatct cacgcgcgat ggcccggatg gtcacatttt
    17521 ccgggccctc ctgaaccagg agcgtccggg cgacgtcctt gatttcacgg atggtcgcga
    17581 tgcgcagccg ctcgcgccgt gagtacggtg cgacgtgcgc ttcccctggc gacacgcgtc
    17641 cccctccctg atgctgcgcc gctcgacaac ccggcgtaca cgcacacgat acagcgcctc
    17701 cgtttagtga acagcggcgg tgacagagcc tctggttcaa ctgctagctc cccgaccctg
    17761 ccacagatcc gtcgggatgc cccgccggat ggctcagcga ccaccgtccg ggtcaccgga
    17821 gggcgcgcgg gagcgtgcct gcatacgtcg gacattcatt cgggaggaat gcgcgcgagt
    17881 ggtccggtaa gcggccgggg aaccgctgac cgccatacgc ggtaccgctc tgcggtaaac
    17941 aggcgtagcg gaggtgagat cgacttcttg tgcgcctcgt cggaggtgcg gaaaggtccc
    18001 gttcccgcca ctcgggcggg gcggaaagga aaccgaccgg tcgggacact ggctttccac
    18061 ttcgacccgt cggcgggggc ctcgagcgcc cggagaaaac gggtcatggc attgcggccg
    18121 gcggcgccgt ggcgttcggc caccggaggt ttccgcggct cagccggagg atgccgccgc
    18181 gacgcgggag cacttccgcg cggttcaccc ggggcgatct ccgctcacac cgcccggccc
    18241 atccgaatag gaagcggcgg aagcaagggc ggataccgat gagagatatc gcccttgtct
    18301 cccatatccg gcacccggcc tgcggacttt cgcggtggac cggcagggcg cccacgagaa
    18361 gaccggactg ggcggttccc acgggccgcg cccttcgaga gctcccgtac accgtccgca
    18421 ttcccgtccg gatcacggcg aggaacgctt tccccgaaaa gcgtcagggc ccgtcgacaa
    18481 cacctgcccg ccgcggctcc ccaaccccgg cgacggccgc gcccattacc acatctgttc
    18541 ggtttctatt cggtcagcag ttcaatccgc aaccgttctc gccgcgctat cccgggccgg
    18601 agcgaacgca tgaaatcaag gaagccggcg atatctcact cggccgggaa ctccgattcc
    18661 gcttccgctg tcggagcgcg gcggaagagt gcgcccacgt ccatgatcat caccttgtgc
    18721 gcatccgcca acgcgccctc cccgaacggc gtttacggta tttttaccag ccgtaccgcc
    18781 cgcgcgacag actacggacg cgcggcgctc gccgacgggt gacggcaggg cctcaaggtc
    18841 ggtgggggca cgcggcggat tcggcggggg cggtgcgccg gggcggccgg ggcacggcgg
    18901 tgccgcgctc acacgcggtc accggccccg agccgaacgg gagatacgcc atccgcggcc
    18961 gctccttgat ggcccgccgg gtgggcggcg attgaccgac ggggtagcgg gcgcgcgccc
    19021 tgccgccgcg gacgcccttg gccaccaccc tcgccaccct ccgggccaca tcgtcgggct
    19081 ggatggcgaa gctgcccgcc agggtgcggc ggctgccggt gtagatcgcc tcgaagtact
    19141 cggcgctctc ccggcggaag gtctcgtacg tccggctcac cggccgcaga ttggccacgt
    19201 aggtggcgcc gaagcgggtg gtgcgcaccg gtcctggctc gaccaggacg acccgcaccc
    19261 cgaagtcggc cacctcgttg cgcagcgagt cgctgagcgc ctccacggcg tgcttggtgg
    19321 cgttgtagaa gcccgagccg gggacggcgt aacggccgga gatggaggag acgttgacga
    19381 tggtgcagcc gccgtgggcg cgcatcccgg gcagcaccag ttggctgagc cggaccagcc
    19441 cgtacacatt ggtctcgaac tgctcgcgca cctcggccat ggaggcttcc tcgatacagc
    19501 ccgacatggc ttagcccgcg ctgttgacca gcgccccgac cacgccgtgt tccgcctcga
    19561 ccttggcgac cgcggtggcc atggactcct cgtcggtgac gtcgagcgaa gatcacccca
    19621 tcggcatcct cagggcatgg gcggcctccg gcgcgggcga gtgggccagc gccttgaggc
    19681 cgagctgcgg ggcggccgag cccagccggt acagcctccg gccctcgcgg tggacaacga
    19741 agccccgccg ggttgtccgg cggggccctg tcgtctatga gaccggtgtt ggcgaaacgg
    19801 ctacttgccg gtctccttct cgtacgcctt gatgacctcg tcggtcgggc cgtccatcag
    19861 cagctcgccc ttctccagcc acagcacccg gtcgcaagtg tcccggatgg acttgttgtt
    19921 gtggctgacg aggaagaccg tgccggcctc ctggcggagc tcgcggatac gggcctcgga
    19981 gcgcttctgg aacttcctgt caccggtggc gagcgcctcg tcgatcatca gcacatcgtg
    20041 gtccttggcc gcggcgatgg agaagcgcag ccgggccgcc ataccggagg agtaggtccg
    20101 catgggcagg gtgatgaagt cacccttctc gttgatgccc gagaagtcca cgatgtcctg
    20161 gtagcgatcc cggatctgct cacgggacat ccccatggcc agaccgccga gaatcacgtt
    20221 ccgctcaccg gtgaggtcgt tcatcagcgc cgcgttcacc ccgagcagcg acggctggcc
    20281 gtcggtgtag accttgccgc gctcggtggg cagcagcccc gcgacggcct tgagcagcgt
    20341 ggacttaccg gagccgttcg acccgatcag accgatcgac tcgcccttgt acgccacgaa
    20401 ggtgaccccg cgcacggcgt gcacctcgcg catccccggg gcgcccttgc ggcgcaggat
    20461 gcggctgagg gcggcggtgg cgctgccctt ccccttgggg ccgccgttca cgcggtagac
    20521 gatgtggacg tcgtcggcga cgacggtggg cacccgcgac cgtgcggaag ccgcctgggc
    20581 ggcctgctcg gccttgccgg cctgctccgc ctgagcggcc ttggcaccct tgtcgagagt
    20641 ctgctcagcc acggccgtac tgctcctctg ccttccagaa gtacacaaag ccaccggcgc
    20701 cgaagagaac cgcccagccc agggccagcg cccagacatg cggcggcagg ttggccgcgg
    20761 tgtagtcgtc gatcagcgcg taccgcatca ggtccatgta cacggcggcc gggttcccca
    20821 gcatggcgtc cgagatccac ttgctcgccc cggcgtgctc cagcgtacgg gccagcggga
    20881 acatcacacc ggacgcgtac atccaggtac ggaggatgaa gggcagcagc tgggcgaggt
    20941 ccggggtctt ggcccccagc cgggccatga tcagcgaaag cccggtgttg aagacgaact
    21001 ggagcgccag cgtgggaagg atcagcagcc aggagaaggc cgggtagtga ccgaatccca
    21061 gcaacacgac gaccagcacg atcatcgaga acaacagctg ctggagctgc tggagcgaga
    21121 acgagatggg gagcgaggcg cgggggaagt gcagggcccg caccagcccg aggttcccgg
    21181 agatcgcccg tacgcccgcc atggcggacg cctgggtgaa ggtgaagacg aacacccccg
    21241 tcaccaggaa cgggatgtac atgtcgttcg gcataccgcg gctgctcttg agcagcaggc
    21301 cgaagatgaa gaagtacacc gccgcgttga gcagcggggt cgccacctgc cacacctgcc
    21361 ccagcttggc ctggctgtac tgggcagtga gcttggccga cgagaaggcc acgatgaagt
    21421 gccgccggcc ccacatctga ttgatgtact cgcgaaggcc cacccgggcg ccactgaccg
    21481 acagcccgta cttctgcgcc agctcggccg gggacaggcc gtcgtcggct gatggcgggc
    21541 cactcacggc taccgcaccg tcgtgcgtag tctcgctcac agttgacact ttcgtcttca
    21601 gggtgcgctg agcggggccg cgccccgggt cgcgcccgat gctcttcgtt acgagcttgt
    21661 cagatgacag gaggtcggcc cagtcgggtc aggcgccata ccgtacgcca cttcatgggc
    21721 cgacgtggac cacacggtgt cttccagcct tctctgaacc ctccgaacca ggcccgaagt
    21781 gcggttttcg agggacgcct ggccagtgtg agcagcagcc agacgcccag atagacgggc
    21841 acgagcagcg caggaaggtt acgccgggcc agccagaccc ggttgcgggc caccatccgg
    21901 tggtagaccg cgtgcctgct cggcgcggtg gtcggatggt gcagcaccat gtccgaccgg
    21961 taatcgatca tccatccggc atccagcgcc cgccaggcca ggtcggtctc ctcatgggcg
    22021 tagaagaagt cgtccggcaa ccccccgacc tgctggaaca ccgcggtacg gaccgcgttg
    22081 gcaccgccga ggaaggtggt cacccgggag gaccgcagcg ggtcggaggc gcgcagccgg
    22141 ggcacatggc gacgctgggt gacaccggtg tcggggtcgg cgatacggaa cgagatgatg
    22201 cccagccccg gatcggcggc gaacgccgca cggcacagct cggccgtgtc ggtgcccggc
    22261 agcagcccgt cgtcgtcgag gaagagcagc acatcgacgt ccgacccgcc gggcccgaac
    22321 gcctcgatgc cgacattgcg ccccgcggga atgcccacgt tctccggcag ctcgacggtc
    22381 cggacgccct cggggagcgg tggcagcggc gagccgttgc ccacgacgac cgcctcgacc
    22441 gggtcgccgt cctgcttggc gaccgagtcc aggagtgcgc gcagctcctc gggacggttg
    22501 cccatcgtca ggacgaccgc tccgaccttc attgtgttca tgctcacttg agcctgctcg
    22561 acgcgaggat ggacacgagg tgaagcaggg tttgcagcag ggcgataccg gccagtacgg
    22621 ccacgcccag ccgggtgaag aacaggtcgc cgcgcacctg gtccacgacc gccagcacga
    22681 ggatgagcag cgatgcctcg atcccgagga ccagccggtg gaacttcagc gccgcggccg
    22741 ccctgcgggc cagcgccaca ccggaggagc gcggctcgga ggccgcctcc ttgaccggtg
    22801 gcagaccgcc ctggtgccgg gcgaccccga cgaggtcggt ctcggccttg atcaggatgg
    22861 cgccgagcgc ggcaagggtg ccgaggaacg cccacagcca gtcgatccgc ccggagcccc
    22921 acagatcggc ggcgcgcaga ccgaagccga cgagcaccgc ggcgtcgcac aggtaggcgc
    22981 cgacccggtc cagatacaca ccgcccagcg agaactgctt cttccaccgg gctatctcgc
    23041 cgtccacgca gtccagcagc aggtagagct ggaccatcag caccccgagc acggcgcccg
    23101 cgatccccgg caccagcagg gccggggcgg cgaggacgcc gaagacggtc atcagatacg
    23161 tcagctggtt gggtgtgacc cgcgtgttca ccaggtaccg gtcgcagcgc agcgagatct
    23221 cccgcatgta caggcgcccg gcccagtgtt caccgctccg ccggtccttc accccttcgg
    23281 ggtggacgac cgggcggagt tcagccactg atggtttgac tgactgcttt ggcatagtcg
    23341 gcgtatgcgt ccctgatcgc gtcggtggac aggtcgaggt gctcgaggat cgtgtagcgg
    23401 ccggggcgcg tcttcggagc gaactccacg acctggacga actcgtccac ggtgaagccg
    23461 atctcctcgg gcagcaccgg cagaccgtgc cggtgcagca cctcggccat atgctccgac
    23521 tcctcgtgcg ccccgcgcag acgcatcgcg aaggcggcgg ccagaccgca ctgctcgccg
    23581 tggctggcgg cgcgcttggg gaagaggagg tcgaaggcgt ggttgatctc gtggcaggca
    23641 ccggaggccg ggcgggagtc ccccgcgacc gacatggaga tgccggtgag caccagtccc
    23701 tcggccagca cctggaggaa gccgtcgtcg ccgaccccgc cggggtggcg cagcacggcc
    23761 tcgccggcct ggcgcgccat cgcggccgcg agcccgtcga tctgttcacc ggtctcgcgg
    23821 tgggacagct cccagtcggc gaccgcggag acattggaca gcgcgtcgcc gataccggag
    23881 cggacgaagc ggaccggcgc ctcccggatc acatcgaggt cgatgaccac ggcgatcggg
    23941 ttgggcaccc cgtacgagcc gcggcccgcg tcgttgtcga gggtcgcgac cggggagcac
    24001 agaccgtcgt gcgagaggtt ggtggcgacg gcgaccagcg gaaggccgat gcgcgccgcg
    24061 gcgaacttcg cacagtcgat gatctttccg ccgcccagcc ccacgaccgc gtcgtagtgc
    24121 cccgacttca tgcggtcggc gagcttgatc gcgtcgtcca gggtgccgcc gccgacctcg
    24181 taccagctcg cgcccggcag cgcgggcgcc agccgctcgc gcagcacggc gccggagccg
    24241 ccgctgatgg cgatcgccag cttgccggag gcggagatcc gctggtcggc gaggaccccc
    24301 gcgagatcgt ccagggcgcc cgcgcggatg tcgacgacga gcggcgaggg gatgagcctc
    24361 gtcagtacag gcacgcgatt tcacggccct tcgccagatc gtcgtggttg tcgatctcga
    24421 cccacttgac gtcgccgatc ggcgccacgt ccaccttgaa gccccggttg accagctcct
    24481 gatagccgtc ctcgtagtag aggtcggggt cgcgctcgaa ggtggtcttc agcgcgtccg
    24541 cgaggtcggc ggcggcctcg ccctcgatga gggtgacgcc gatgtactca ccggtcgcct
    24601 cggccgggtc catcagcttg gtgatcttct ggacgccctt gtcggggtcg gcgacgacct
    24661 tcatctcctc gtcggcgagc tgcttgacgg tgtccagggc gaggatgatc ttctgcccgt
    24721 tgccgcgcgc ggccagcagg gtcttctcga ccgagaccgg gtgcacggtg tcgccgttgg
    24781 cgaggatcac ggagtgctgg atcgcgtcac gggcgcacca cagagagtag gcgttgttcc
    24841 actcctcggc cttgtcgttg tcgatcagcg tgagcttcac gccgtacttc cgctccaggg
    24901 cctccttgcg ctcgtacacg gcctccttgc ggtagccgac gacgatggcg acctcggtca
    24961 gaccgatctc cgcgaagttg ccgagggtca ggtcgaggac ggtcgtctcg tcttccttcc
    25021 cctcgggtcc caccggcacc agcgccttgg gaagcgtgtc ggtgtagggg cgcagacgcc
    25081 gtccggcgcc ggccgcgagc acgaggccga tcatgcgggt tctcctgttt cgtcgtgtac
    25141 ggcgggtgct cctgaggaca cccagaagcg gatgctctcg gtgagcaccg ccagcgcgag
    25201 agccgccgcc aaagcggtca acgcgatggt gaaaccttgg ttccggtggt gcagcagggc
    25261 agcggcggcc gtgaccgcca ccgtccgccc ctcgtgcccg ccgatcgccc gcaccagcag
    25321 gtgcggaggc gcccccgtgc cgccccggat gcggtacacg gtgtcgtagt gatggtaggc
    25381 gacggccgca atcagcccga aagccgccgg caaggcgccg ttcacctccg agcaagccac
    25441 aagaatgagg atgacgccgt attcggcggc gcggaagagc ggcggcacca gccagtcgag
    25501 cgggcccttg agcggcgcgg cgacggcgac gcccgcaagg accgcgtaga gcaccgcgca
    25561 tccgaccggc acccaggagc cgaaaccggc ggccgcggtg ccggccagga cggccgcggc
    25621 cccgagggcg gcggagagcg gggcgaggta cgaactcggc ccgcgggggg cggccttggc
    25681 caccagctcg gccagcggac cggtgtccgc gagctcggcg agggcgtggg cggcccggtc
    25741 ggtgcgctcg gcccggcggg tcagcgagcg cagcacccgg ccggcggtgg tgtagcaggc
    25801 ggccagcgca cagccgacga gcagcacata gaaggtgatg cggggggtgg tgaacgccgt
    25861 cagcacggcg atcatcgccc agcgctcacc aatcggcagc acgatcatgc ggcgcaccca
    25921 gaccgtccag ccgacgctgt ccaggcggcc ggagagggcg gcggtggggc tggtgttgcc
    25981 ggtggcgtcg tggttggcct cgttgaaggc gaagtccacg acatggcggc aggtctggag
    26041 caccatcgcg ccgagcgcga gcgcccagac gtcatcgccg tcggcgcggg cggcgccgag
    26101 ggcgaggccc gcgtagtagg cgtactcctt ggcccggtcg aacgtggcgt ccagccaggc
    26161 gccgagcgtg gagtactgga gcgagtagcg ggccagctgc ccgtcggtgc agtcgagcac
    26221 gaacgaggcg atcagcagca caccggccga gacgaacccg ggccgggtgc cggtggcggc
    26281 gcacgccgcc gcgatgagcg cggtgagcag ggaagcggtg gtgacctggt tgggggtcag
    26341 cccgcgccgg gcgcaccagc gggcgatata gcgggagtac gggctgatgc agaaggtcgt
    26401 gaagaagccg tcccgcgact tcaccgcgga ccgcagccgc acccgctcgt cgtc
//
