LOCUS       NZ_CP025018            22092 bp    DNA     linear   CON 12-FEB-2024
DEFINITION  Streptomyces sp. M56 chromosome.
ACCESSION   NZ_CP025018
VERSION     NZ_CP025018.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. M56
  ORGANISM  Streptomyces sp. M56
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11742376)
  AUTHORS   Kim,K.K.Hyun., Klassen,J.L., Ruzzini,A.A.C., Beemelmanns,C.C. and
            Clardy,J.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-NOV-2017) Leibniz Institute for Natural Product
            Research and Infection Biology - Hans Knoll Institute,
            Adolf-Reichwein-Strasse 23, Jena 07745, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-AUG-2014
            Assembly Method                   :: HGAP v. AUG-2014
            Assembly Name                     :: M56v2
            Expected Final Version            :: yes
            Genome Coverage                   :: 94.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/12/2024 06:37:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,558
            CDSs (total)                      :: 9,473
            Genes (coding)                    :: 9,167
            CDSs (with protein)               :: 9,167
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 306
            CDSs (without protein)            :: 306
            Pseudo Genes (ambiguous residues) :: 0 of 306
            Pseudo Genes (frameshifted)       :: 86 of 306
            Pseudo Genes (incomplete)         :: 261 of 306
            Pseudo Genes (internal stop)      :: 28 of 306
            Pseudo Genes (multiple problems)  :: 61 of 306
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:58:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2155092
            Orig. end                         :: 2177184
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP025018.1.
            Annotated using prokka 1.11 from http://www.vicbioinformatics.com.
            Bacteria and source DNA available from Christine Beemelmanns.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22092
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="13"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22092
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22092
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12092](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12092)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            144..479
                     /locus_tag="CFP59_RS08090"
                     /old_locus_tag="CFP59_01596"
     CDS             144..479
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056920.1"
                     /locus_tag="CFP59_RS08090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01596"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_079259937.1"
                     /transl_table=11
                     /translation="MEKQPYVCGLDAAVDVIDGKWKVLIIWALNHQRCRFGELKRLVPG
                     VSEKVLTQQLRELAADGIVHRESYDVVPPKVEYSLTGLGEELNTALRPLGAWGKRRMAT
                     LAETGRG"
     misc_feature    complement(566..577)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.39"
                     /tool="antismash"
     gene            634..1974
                     /locus_tag="CFP59_RS08095"
                     /old_locus_tag="CFP59_01597"
     CDS             634..1974
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1074: major
                     facilitator family transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056919.1"
                     /locus_tag="CFP59_RS08095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01597"
                     /product="MFS transporter"
                     /protein_id="WP_100805393.1"
                     /transl_table=11
                     /translation="MTDSAPRSQPRTPWRAVFGGSIGNLVEWYDWFVYASFATYFAGAF
                     FPKGNDTAQLLNTAGIFAVGFFMRPVGGWLLGRFADRRGRKAALTLTVSLMSASALLIA
                     IAPTYDQVGYFGAGVLLVARLLQGLSVGGEYAASATYLTEASRPGGRGFVSSFQYVSMT
                     MGQLIGLGLQIVLQHTMSDDALHSYGWRIPFIVGAVGAAVVFWLRRNLLETEIYAEEDA
                     HQDQERGTIAELLRHRKEAALVIALTMGGTVAYYTYTTYLTKYLSNTAGMSKSDASLVS
                     FCALFLFMLLQPLAGALSDRIGRRPLLITFGFGSMLGTVPIMTALSHADTFTGALLLSL
                     AALVIVTGYTSINAVVKAELFPTHVRALGVALPYALANALFGGTAEYVALWFKKGGVES
                     GYYWYVSACAAVSLIVYLTMRETRDAALSRDRADGPAAPGKQRTTAV"
     gene            complement(1999..2466)
                     /locus_tag="CFP59_RS08100"
                     /old_locus_tag="CFP59_01598"
     CDS             complement(1999..2466)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056918.1"
                     /locus_tag="CFP59_RS08100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01598"
                     /product="ATP-binding protein"
                     /protein_id="WP_069860415.1"
                     /transl_table=11
                     /translation="MAVALRQRSTMAHHPSPGSVDSALRQERFQLPARGASVAIARHRV
                     RSRVPEWGFHEDLCDAAELVMSELFTNALVHTGSEQILCVLRAHERRMLYVEVADQGGG
                     PAVPTPREAGLEDECGRGLALVRALADAWGDRPGVDGGRVVWAQMSVAVGR"
     misc_feature    complement(2601..2613)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.63"
                     /tool="antismash"
     gene            2692..3549
                     /locus_tag="CFP59_RS08105"
                     /old_locus_tag="CFP59_01599"
     CDS             2692..3549
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712676.1"
                     /locus_tag="CFP59_RS08105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01599"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_069860414.1"
                     /transl_table=11
                     /translation="MGEARSAPTVGQMVLGMRLRDLREKAGVNYDQAARALHVNQTTVR
                     RMEKAEVGLKLPYVEKLLQTYGADQEEIDSFLALAEEANRPGWWHRFRDVLPDWFSLYV
                     SLEGAASRIRAYEPHFVPGLLQTEDYARTLLSIGFPHGSDRELERRVALRMERQELLHR
                     PNGPHLWVVMDETVLRLAIGGPEVMRAQVDHLIEAAQRPNVTLQVVPFSAGPHPGMGGP
                     FQLFRFQIPELPDIVYAEGLTGAGYLDQRSDVVAYLEALDRMGTQATPARRTESFLRGI
                     RKEL"
     gene            3552..3848
                     /locus_tag="CFP59_RS08110"
                     /old_locus_tag="CFP59_01600"
     CDS             3552..3848
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542876.1"
                     /locus_tag="CFP59_RS08110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01600"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_069860413.1"
                     /transl_table=11
                     /translation="MDQVDVYNGMPAKQLAIEGWAKPWSGPNGGACVEALRLKDGRVAL
                     RQSTDPDGPALIYTHHEIERFIQGAKAGAADFLLTRPENLTTSAGSAPERRAA"
     gene            3845..4663
                     /locus_tag="CFP59_RS08115"
                     /old_locus_tag="CFP59_01601"
     CDS             3845..4663
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056915.1"
                     /locus_tag="CFP59_RS08115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01601"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_079259935.1"
                     /transl_table=11
                     /translation="MTDYGLAPDQIDTTKPHPARMYDFYLNGKDHYEVDAEAAGRVLEV
                     YPTVRLNATVNRGFIHRATRWLAREAGVRQFLDIGTGIPTEPNLHQVAQGVIPEARVVY
                     TDYDPIVLAYAQALLIGTPEGRTAYVQSDVRDPERIMSAPELHETLDLTQPVAISVNAL
                     FHFIPEEDKPYEIVRKLMEPLVPGSYLMLTHSTHDFSEETWRNVIQVYKESGISFTTRS
                     QSEVGAFFDGLELIDPGVSEPHQWKPDPGDRPEAIRSADINMWAGVARKS"
     gene            complement(4688..6112)
                     /locus_tag="CFP59_RS08120"
                     /old_locus_tag="CFP59_01602"
     CDS             complement(4688..6112)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056914.1"
                     /locus_tag="CFP59_RS08120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01602"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_100805394.1"
                     /transl_table=11
                     /translation="MVRLPRLRRRRPSLRTTFALSFSAAATVVTLLVGGLSYDAAAGLV
                     RVDQQSAFDDVIHDLRGQVRGDKVVLRQYPTESTGPVPYDLRDDLRRISRMDVQVINGR
                     GTVYDAGKPPLPVTDEDRTTAAAHTAGTVVRREIDIGGEQYRMATVAVGDGTGAVQVAQ
                     QISDTEDLLQELQQRTALFVVAVILAAGLAGWWLAGRITRRLVRLTRVAESVAATGRME
                     VAVPVAGDDEVGRLGRAFDGMLGQLARSKDDQRRLVQDAGHELRTPLTSLRTNISLLRR
                     FEDLPGPAREDLLADLAGETRELTDLVNELVDLAAGQRDDEPRTEVSLEEVATTAVTLA
                     RRRTGREITVRASGDTRLTGHPATLQRAISNLVENAAKFDQDGTGPVEVMISGRRVEVL
                     DRGPGIAAEDRERVFDRFYRAPGARSLPGSGLGLAIVREVALAHGGTVFARPRPGGGAI
                     LGFTVGDGTGAIGTGP"
     gene            complement(6112..6816)
                     /locus_tag="CFP59_RS08125"
                     /old_locus_tag="CFP59_01603"
     CDS             complement(6112..6816)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056913.1"
                     /locus_tag="CFP59_RS08125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01603"
                     /product="response regulator transcription factor"
                     /protein_id="WP_079259933.1"
                     /transl_table=11
                     /translation="MTNTVLLAEDDRAIRQALERALTLEGYRVTGVPDGIEALAAIHRE
                     RPDVVVLDVMMPGVDGLQVCRVLRAEGDRTPILMLTARVETADRIEGLDAGADDYVAKP
                     FEVEEVFARLRALLRRAAPAEPAAPEDTAIDGVLEVSDLRLDSSARRVWRGGTELELTR
                     TEFDLLELLARNAGIVLDHATIYARIWGYDFGPGSKNLAVYIGYLRRKVDPEGRTPLIH
                     TVRGVGYTLREE"
     misc_feature    6887..6902
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     gene            6992..8257
                     /locus_tag="CFP59_RS08130"
                     /old_locus_tag="CFP59_01604"
     CDS             6992..8257
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056912.1"
                     /locus_tag="CFP59_RS08130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01604"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_100805395.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 3.2e-37,
                     bitscore: 126.9, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIAFLLHNAYGIGGTIRTTMNLATALADRHEVEIVSMMRHRETP
                     RFALDPRVRLVPLVDTRPNGADAKDPLFFEASRDFPAAEKRHHQYNRLIDTRAAEYLRD
                     CPADVIVGTRPGVNVYISRFAPRRALRIAQEHLRYEAHSKKLRAELAPYYRSLDAVVTT
                     TEADAAVYREKMPMPGVRTLAIPNSVPEPAVAPSEGTAPVIAAAGRLVRGKRFDLLIDA
                     FAEVSEKYPDWRLRIYGGGAEKERLAEHIERLGLSGSAELMGSYSPIEAEFAKASLVAV
                     ASDAESFGMTIVEAMRCGVPVVSTDCPLGPAEIIRDGVTGRLVPTGDKHALASALMELM
                     ADAPARRAMGAAALEGSRIYDPAPIARRYDQLFEELRASRFARGWERYRTAARARWRRL
                     ARRFGIAPGRRRTPAAGEKASA"
     gene            complement(8432..9910)
                     /locus_tag="CFP59_RS08135"
                     /old_locus_tag="CFP59_01605"
     CDS             complement(8432..9910)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947291.1"
                     /locus_tag="CFP59_RS08135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01605"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_069860408.1"
                     /transl_table=11
                     /translation="MTVTDEGRAERATAEGPGIDPERLATCLSVLAELDRLPVDHPDAI
                     TVRRATSGIYRSVKQRRRQERRAAKTANDKAVTEATATGAADRIDDETLGLALTSSVST
                     EIAGILARPRSCYVCKTRYVEVDAFYHQLCRDCAAENRARRDARTDLTGRRALLTGGRA
                     KIGMYIALRLLRDGAHTTVTTRFPGDAVRRFKAMPDSAEWLHRLKVVGIDLRDPAQVIA
                     LTDEVSAAGPLDILINNAAQTVRRTPQAYAELIAGESAPPPAGELPESLVLGAFGSGAQ
                     AALPGPRAARDGALTPQDLTALALTSGSASPARIEAGTAIDAGGLVPDLDPTNTWVQRV
                     DEVDPVELLEVQLCNETAPFILVSRLRPAMAASPARRKYVVNVSAMEGKFGRGYKGAGH
                     PHTNMAKAALNMLTRTSAREMFEADSILMTSVDTGWITDERPHPEKIRLAAEGFHAPLD
                     LVDGAARVYDPIVRGEAGEDLFGCFLKDYAPTSW"
     gene            complement(10001..11107)
                     /gene="pqqE"
                     /locus_tag="CFP59_RS08140"
                     /old_locus_tag="CFP59_01606"
     CDS             complement(10001..11107)
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056910.1"
                     /locus_tag="CFP59_RS08140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01606"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_100805396.1"
                     /sec_met_domain="PF04055 (E-value: 4.6e-22, bitscore: 78.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 8e-06, bitscore: 25.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.9e-06, bitscore: 26.3,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 9.9e-08, bitscore:
                     31.4, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAPRPWALLAELTHGCPLHCPYCSNPLELVRRSRELSTAEWAE
                     VMRQAGEFGVVHTHLSGGEPLLRGDLAEIVTAAESAGIYTQLVTSGVGLDGARLATLTA
                     AGLRSVQLSVQHADPAAADRIAGHRAFAAKERAAALVRAAGLPLGLNVVLHRDNLDALD
                     ALIRRGVDWGADRIELANTQFYGWALRNRDALLPTRDQLARARETVQRWRDRLGGATDL
                     VWVVPDYFDGVAKPCMGGWGAVSLTVAPDGTALPCPAAASLPDLDPPNVRDHSLEWIWD
                     HSGAFNRYRGEGWMREPCRTCSRRAEDFGGCRCQAYALTGDATRTDPACALSPDHGVIR
                     ALTDTGHPAAAATPAPTGGYAYRKPGGG"
     gene            complement(11104..11388)
                     /gene="pqqD"
                     /locus_tag="CFP59_RS08145"
                     /old_locus_tag="CFP59_01607"
     CDS             complement(11104..11388)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056909.1"
                     /locus_tag="CFP59_RS08145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01607"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_069860406.1"
                     /sec_met_domain="PqqD_RRE (E-value: 7.5e-19, bitscore:
                     66.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.5e-11, bitscore: 43.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAGTPPAPAGWRPALAPAVSLRHDRVRDADLLVLPERVVVLRG
                     SAARILRLCDGDRDLEAIVAELESRFPGAPVADDVRAFLGRMRGEGWVR"
     aSDomain        complement(11110..11349)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CFP59_RS08145_PqqD_RRE.1"
                     /evalue="2.20E-21"
                     /identifier="RREFam006.1"
                     /label="CFP59_RS08145"
                     /locus_tag="CFP59_RS08145"
                     /protein_end="93"
                     /protein_start="13"
                     /score="66.4"
                     /tool="antismash"
                     /translation="RPALAPAVSLRHDRVRDADLLVLPERVVVLRGSAARILRLCDGDR
                     DLEAIVAELESRFPGAPVADDVRAFLGRMRGEGWV"
     gene            complement(11385..12092)
                     /gene="pqqC"
                     /locus_tag="CFP59_RS08150"
                     /old_locus_tag="CFP59_01608"
     CDS             complement(11385..12092)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056908.1"
                     /locus_tag="CFP59_RS08150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01608"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_069860405.1"
                     /sec_met_domain="TIGR02111 (E-value: 3.2e-83, bitscore:
                     277.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPRTRLEERLRAVAQERYHDRHPFNVRMHAGELTPAELRRWIL
                     NRFHYQRHIPVKDALITAKFDTPRLRRMWLRRIQDHDGTTEGEGGIERWLRLGEAAGLH
                     RDRLLSAEEVVPGVRLAVDGYVNFCRLRGPLEAVAASLTELSAPGIMLTRIDAFERYYP
                     WIEREGLAYFRNRVDQGRRDSTEALDAVLTWARTPEDEDRAVAALAFKCDVLWSLLDAV
                     DHADTKDGPGEGT"
     gene            complement(12089..12988)
                     /gene="pqqB"
                     /locus_tag="CFP59_RS08155"
                     /old_locus_tag="CFP59_01609"
     CDS             complement(12089..12988)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056907.1"
                     /locus_tag="CFP59_RS08155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01609"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_100805397.1"
                     /transl_table=11
                     /translation="MRVRVLGTAAGGGVPQWNCACPGCSGARAHPGWRRRHASLAVQAA
                     EGRWYLVNATPDLGDQVEDHPELHPGPEPRRTPLAGLILTDAELDHTLGIARLREADGI
                     EIVATAPVRHALLTGLHLGEVLTPYARLDWRPLGPEDRPLAEDSPLVVGAVPVSAKRPR
                     YAAGLDAPDDGGWVVALRLTDRTTGRSLLYAPALAAWSDTFQNAAESADHVIVDGTFWS
                     DDEPLSSGFGSRTATAMGHLPIDGPDGTARRLAALEGRTLYTHLNNTNPLNDPAAPHHT
                     ELRKLGVEVAADGMVIDL"
     gene            complement(12999..13142)
                     /gene="pqqA"
                     /locus_tag="CFP59_RS08160"
                     /old_locus_tag="CFP59_01610"
     CDS             complement(12999..13142)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_093467075.1"
                     /locus_tag="CFP59_RS08160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01610"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_100805398.1"
                     /transl_table=11
                     /translation="MNDTTPRTTPEAADRTRTDAGQTAWQTPDYVVVETALEVTAYSLN
                     AR"
     misc_feature    13309..13325
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.36"
                     /tool="antismash"
     gene            13542..14621
                     /locus_tag="CFP59_RS08165"
                     /old_locus_tag="CFP59_01611"
     CDS             13542..14621
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712691.1"
                     /locus_tag="CFP59_RS08165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01611"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_099015817.1"
                     /transl_table=11
                     /translation="MKRYRNTAAAAAATALAAGLLIGTAGTGTAAPGRADSAPSDIKTV
                     SSGWTVPWGLSWLPDGSALLTERDSFKVYKLTQSGTRTEVGTVPNVVTTDGEGGLLGIA
                     VSPNWNSDHTIYLMHTASEGNRIARMTYDGSSLGGYQTLVTGIKKNKYHNGGRLKFGPD
                     GYLYATTGEAQTPDLSQDKNSLNGKILRMTTDGKPAPGNPFGTLVYSYGHRNPQGITWD
                     PQGRLWEAEFGDSKYDELNLIEAGKNYGWPICEGECSTAGMTGPKRQWPTGDASPSGVT
                     YADGAMYLAALRGERLWRIPVDGTNAGTPKAYYTSSYGRLRTVETVPGKNTLWLSTTNA
                     DSNGGEPDGADKVFQVELK"
     gene            complement(14684..15829)
                     /locus_tag="CFP59_RS08170"
                     /old_locus_tag="CFP59_01612"
     CDS             complement(14684..15829)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712692.1"
                     /locus_tag="CFP59_RS08170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01612"
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="WP_100805399.1"
                     /transl_table=11
                     /translation="MISRRTLFASTLGLTGGLLLPTAGAGAAPADWSRAVVDSTIARRP
                     DPASLGGWGYIQGLFLLGTYRVHQRVDEPSYLAYLKRWVDNFVDADGHMSRTFDNLDAM
                     QAGNLLLILHQETGDPRYRTAAGQIRARITTYPRTADGGMWHATGRTNELWGDGVFMAQ
                     PFLLRYGIAYGDQEYAYEEVTRNLSVYFRHLRAANGLIYHGYDADGDAPWKPDPTTGTS
                     AHFWARAIGWTAMTHVEVLELLPADHPRRAELIDNVRHLAKGFARYQDPATGRWFQVVD
                     KASEPGNWTETSASSMYTLMLHAALEHGWISGGGYTEAVRRGYEGVLRKVSVGSDGLTN
                     ITDISEGTNVGDLAYYLGRARNTNDLHGLGAFLLMNERLAH"
     misc_feature    complement(15799..15814)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.49"
                     /tool="antismash"
     misc_feature    complement(15967..15985)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 28.03"
                     /tool="antismash"
     gene            16002..17027
                     /locus_tag="CFP59_RS08175"
                     /old_locus_tag="CFP59_01613"
     CDS             16002..17027
                     /GO_process="GO:0015891 - siderophore transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056895.1"
                     /locus_tag="CFP59_RS08175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01613"
                     /product="iron-siderophore ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_100805400.1"
                     /transl_table=11
                     /translation="MGPLRLFPLLSAVLAATVLTGCGSSDPASSSASSGSSGSSGSSGS
                     SAVSKAPGSSAADGDFPRTVAHEQGSTPLKAAPKRIAAISTGQLDDLLTLGVVPVATTR
                     ADYAGLVPDYLRTAFPRQAEALGSMTDIGTRTSPNLEKLAAAKPDLILVNSTQGALYPS
                     LAAIAPTVVTKGRGVNWKKDLLTVADAVGRRERARTLLTRFEKDAADQGEKLGGEHTAL
                     SMVRFNPDRVRMFGKKSFTGTIADDMGLGRPESQRFDDISQDLSGERIPQTDGDWIFYS
                     VQGRPGKTDAATYLSNPLWKKLGAVRGGHIAKVDDDPWYLNAGPTAARVVLRDITEHLG
                     R"
     gene            17295..18653
                     /locus_tag="CFP59_RS08180"
                     /old_locus_tag="CFP59_01614"
     CDS             17295..18653
                     /EC_number="6.3.1.-"
                     /GO_function="GO:0004356 - glutamine synthetase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006542 - glutamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056894.1"
                     /locus_tag="CFP59_RS08180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01614"
                     /product="glutamine synthetase family protein"
                     /protein_id="WP_079259926.1"
                     /transl_table=11
                     /translation="MGTGDREQAYARARQEAERLTANGIQGIALTWVDNAGLTRVKSVP
                     TARLPQAARRGVGMSPVFDVYLVDDSMTTSRHVGGPDGDLRLLPDLERLTPLAAQPGWA
                     WAPVDRYDQEGRAHPVCQRLFARRMAERARERGLAVRMGFETEWVVTTGDPDQDPPHYP
                     TTGPAYGMARLVDLADYLADLLGALDAQHTEVHQLHPEYSPGQFEVSLAPTDPVAAADL
                     AVLVRETIRACSGRAGLNPMFGPVVDPGGVGNGAHLHLSLWQGDRNLCRDGDGPHAMTA
                     TAEAFLAGVLRELPALLAIGAPSPASYLRLEPSRWAGAYQCWGLENREAAVRFITGAPD
                     DPGAANAEIKSFDPAANPYLVAGAVIAAGLGGLDAGLSLPPPVSGDPAVEGRERRLPTS
                     LLTALEHFEDSTVLREALGDPLFESIAAVRRAEAALFEKSSPREIAIATRRRY"
     gene            18657..19835
                     /locus_tag="CFP59_RS08185"
                     /old_locus_tag="CFP59_01615"
     CDS             18657..19835
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056893.1"
                     /locus_tag="CFP59_RS08185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01615"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_173963160.1"
                     /transl_table=11
                     /translation="MEAAEQTDPTEPPLPLLPPLVDHHCHGVVRSELGSAAFEAFLTES
                     DAPAALGTTFFDSQLGFAVRRWCPPLLGLEPHCPPAHYLARRRELGAREVARRLLSATG
                     ISEFLVDTGLPGNLTTPQELALAAGGTAHEIVRLEQLAERIADTSLTADDFLTGVADGI
                     REAARTAAGFKSVAAYRYGLDFEPDPPGPGAVHTAAERWLARRGQGGTAAARVTDPVLL
                     RHLLWSAAYTGLPLQLHTGFGDPDLRLDRCDPLALTDFVRAVRPTGCTLILLHGYPYHR
                     GAAYLAAVFPHVYADVGLALSHTGARAGAVLAEMLELAPFGKVLFSTDAYGLPELYVVG
                     ARLFREALTGLLTHWVAEGAWSRRDARRVAALLGADNARRVYGLGTPAPRAG"
     gene            complement(20008..20790)
                     /locus_tag="CFP59_RS08190"
                     /old_locus_tag="CFP59_01616"
     CDS             complement(20008..20790)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029963.1"
                     /locus_tag="CFP59_RS08190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01616"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_100805401.1"
                     /transl_table=11
                     /translation="MRVRRLGWAGVEVEAGGRRLVVDYVRDLSPLFTGWKPGEGLAEPS
                     GRATAALVTHLHRDHTDASALADALTPGAPVLRPAPGHGDDVDNVTTLPAERELALHRL
                     AAEVVDAWSTREFGPFRVTAVPSVDGLGDPQLNWVVQADGQRVFHGGDTMFHGYWWLIA
                     RRFSPFDAVFLPANGAVVDAPHLQPPSPLPAALDPRQAAAAAEILDARYAVPIHYEPEQ
                     PDKIAGYVEVSDPEKEFRTHAGRRAHVLAVGEWLDLAT"
     gene            20885..21487
                     /locus_tag="CFP59_RS08195"
                     /old_locus_tag="CFP59_01617"
     CDS             20885..21487
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014054208.1"
                     /locus_tag="CFP59_RS08195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CFP59_01617"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_100805402.1"
                     /transl_table=11
                     /translation="MSPRRSAAEAQATRGRILGRAAEIASEEGLDGITIGRLAEELEMS
                     KSGVHKHFGTKETLQISTLDKAFVDFWHRVVEPTLTEPPGLRRLRAVCANSVGYLEAPL
                     LPGGCLMTAALTEYDGRPGRVRDAVAEVWSRWREQLRADLTAAVENGELPAGFDIDQAL
                     FEIIAAGLALNAAMQLQHDRAAAGRARRAIERALAQP"
     misc_feature    21965..21984
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 24.8"
                     /tool="antismash"
ORIGIN
        1 ttcgctcatc ttcattgctc cagttgttcc gataccgctt tgtcgtaggg gtccggcgcg
       61 ccgatcacag actccttcct cggcggtaat gtggacaagt acgcactaaa aagtgcgtac
      121 ttaccttgag gtcagtgggg gccatggaaa agcagccgta tgtctgcggt ctggacgcgg
      181 ccgtggatgt gatcgacggc aagtggaaag tgctgatcat ttgggcgctc aatcaccagc
      241 ggtgccgttt cggggaattg aagcggcttg ttcccggtgt gagtgaaaag gtgctgacac
      301 agcagctgag ggagttggcg gcggacggaa tcgtccaccg ggagagctac gacgtggtgc
      361 cgccgaaggt ggagtattcg ctgaccgggc tgggcgagga gctgaatacg gcgctgcgcc
      421 cgctgggcgc ctggggcaag cgccggatgg cgacgctggc ggagaccggc cggggctgag
      481 cgctccgccg gacgccgggc cgctcggccc gagaaggtcg cccgggggcg cgacgaaggt
      541 cacccggggg cgcgaccccg ccgcggaatc ccttttccaa ctggccctgt gcggggtagg
      601 ggtgagggat caccccgctc acttggaggc cccgtgaccg acagcgctcc ccggagccaa
      661 ccacgcacac cctggcgagc cgtgttcggc ggctcgatcg gaaatctcgt cgagtggtac
      721 gactggttcg tctacgccag tttcgccacc tacttcgccg gagccttctt ccccaagggc
      781 aacgacaccg cacagctcct caacaccgcc gggatcttcg cggtcgggtt cttcatgcgt
      841 cccgtcggcg gctggctgct gggccggttc gccgaccggc gcggccgtaa ggcggcgctc
      901 accctgacgg tgtcgctgat gtcggccagc gcgctgctca tcgccatcgc cccgacctat
      961 gaccaggtcg gctacttcgg cgcgggcgtg ctgctggtgg cgcggctgct ccagggcctg
     1021 tcggtgggcg gtgagtacgc ggccagcgcc acctatctca ccgaggcgtc ccggcccggc
     1081 ggccggggct tcgtctccag cttccagtac gtgtcgatga cgatgggtca gctgatcggc
     1141 ctcggtctcc agatcgtgct ccagcacacc atgtccgatg acgcgctgca ctcctacggc
     1201 tggcgcattc cgttcatcgt cggcgccgtg ggcgcggccg tggtcttctg gctgcggcgc
     1261 aatctgctgg agaccgagat ctacgccgag gaggacgccc accaggacca ggagcggggg
     1321 accatcgccg agctgctgcg ccaccgcaag gaggcggcgc tcgtcatcgc gctgaccatg
     1381 ggcggcacgg tcgcgtacta cacgtacacc acctatctga ccaagtacct gtcgaacacg
     1441 gccggaatga gcaagtccga cgcgtcgctg gtcagcttct gtgccctgtt cctgttcatg
     1501 ctgttgcagc cgctggccgg ggcgctctcg gaccggatcg gccgccgtcc gctgctgatc
     1561 actttcggct tcggctcgat gctgggcacc gtgcccatca tgaccgcgct ctcacacgcc
     1621 gacaccttca ccggggcgct gctgctctcg ctcgcggcgc tggtcatcgt caccggctac
     1681 acgtcgatca acgcggtggt gaaggcggag ctgttcccca cccatgtccg ggcgctcggg
     1741 gtggccctgc cgtacgcgct ggcgaacgcg ctgttcggcg gcaccgccga gtatgtggcg
     1801 ctgtggttca agaagggcgg tgtggagtcc gggtactact ggtacgtctc ggcgtgtgcg
     1861 gccgtctcgc tcatcgtcta cctcaccatg cgggagaccc gcgacgccgc cctctcccgg
     1921 gaccgcgccg atggcccggc cgccccgggg aagcagcgga cgacggcggt gtgacggggg
     1981 cggcgggccg gatccgggtc agcggccgac ggccacgctc atctgggccc agaccacccg
     2041 tccgccgtcc acgcccggcc tgtcccccca cgcgtcggcc agggcgcgga ccagtgccag
     2101 tccgcgtccg cactcatcct caagaccggc ctcccgcggc gtggggacgg ccggtccgcc
     2161 gccctggtcg gcgacctcga catagagcat gcgccgctca tgggcgcgca gcacacagag
     2221 gatctgctcg cttccggtgt gcaccagggc gttggtgaac agctcggaca tcaccagctc
     2281 ggcggcgtcg cagagatcct cgtggaagcc ccactccggt acgcgcgagc ggacccggtg
     2341 ccgggcgatg gcgaccgacg cgcctctggc gggcagctgg aacctctcct ggcggagggc
     2401 ggagtcaacg ctcccggggc tcgggtggtg ggccatcgtc gagcgctgac gcaatgccac
     2461 ggccatgtgc cttccgtccg tctacctgtg ggggcgtgaa tgccgtacgt gaatgccgca
     2521 agtgcgcgac acagcagtca cgttggaccg gtcacacccg tcactatcgt tgctgcgagc
     2581 atcagttggc aaggcgcgat ctgcaaaatg cagaatagcc agcgcactct gttgccctca
     2641 cctcgcacgt ggcacactga ttcctgacaa gaccgtccca ggaggtacga cgtgggtgaa
     2701 gcgcgatctg ccccgaccgt cgggcagatg gtcctcggca tgcggctgcg ggaccttcgc
     2761 gagaaagccg gcgtcaacta cgaccaggct gccagggcgc tgcacgtcaa ccagaccacg
     2821 gtgcgcagga tggagaaggc cgaagtcggc ctgaaactgc cctacgtcga gaagctgctg
     2881 caaacctatg gcgccgacca ggaagagatc gactccttcc tcgcactcgc cgaggaggcc
     2941 aacaggcccg gctggtggca ccggttccgt gatgtgctgc cggactggtt cagtctctat
     3001 gtgagcctcg agggcgcggc cagccgtatc cgcgcctacg agccgcactt cgtccccggg
     3061 ctgcttcaga ccgaggacta cgcccgcacg ctcctctcca tcggtttccc gcacgggtcc
     3121 gaccgggagc tcgagcgccg ggtggccctg cggatggagc gccaggagct gctccaccgc
     3181 ccgaacggac cacatctgtg ggtcgtgatg gacgagacgg tgctccgtct ggccatcggc
     3241 ggccccgagg tgatgcgcgc ccaggtggac catctgatcg aggccgcgca aagaccgaac
     3301 gtcacccttc aggtggtgcc gttctccgcc ggcccgcacc cgggcatggg cggccccttc
     3361 cagctcttcc ggttccagat cccggaactg ccggacatcg tctatgccga gggcctgacc
     3421 ggcgccggct atctcgacca acgttccgat gtggtcgcgt atctggaggc cctggaccgc
     3481 atgggcaccc aggccacacc ggcgcggcgc acggagagct ttctccgtgg gattcgcaag
     3541 gagctctgac tgtggatcag gtagatgtgt acaacggcat gccggccaaa cagctggcga
     3601 tcgaaggctg ggccaagccc tggagcggcc ccaacggcgg tgcctgtgtg gaggccctgc
     3661 ggctgaagga cgggcgggtc gccctgcgtc agtcgaccga tccggacggc cctgccctga
     3721 tctacaccca ccatgaaatc gagaggttca tccagggcgc caaggccggc gccgcggact
     3781 tcctgctcac acgcccagaa aacctgacca cctcggcggg ttccgcaccg gaacggaggg
     3841 ccgcgtgacc gactacgggc tcgcccctga ccagatcgac accaccaagc cgcacccggc
     3901 tcggatgtac gacttctacc tcaacggcaa ggaccactac gaggtcgacg cggaggccgc
     3961 cgggcgggtg ctggaggtct atccgaccgt ccggctcaac gcgaccgtca accggggctt
     4021 catccaccgc gccacccgct ggctggcccg ggaggccggg gtccggcagt tcctcgacat
     4081 cggcaccggg atacccaccg agcccaacct ccaccaggtc gcccagggcg tcatcccgga
     4141 ggcccgggtg gtctacaccg actacgaccc catcgtgctg gcctacgccc aggcgctgct
     4201 catcggcacc cccgagggcc gtacggccta tgtgcagtcg gatgtgcgcg accccgagcg
     4261 gatcatgagc gcccccgagc tgcacgagac gctggacctg acccagccgg tggcgatctc
     4321 ggtgaacgcg ctcttccact tcattccgga agaggacaag ccgtacgaga tcgtccgcaa
     4381 gctgatggag cctctggtcc cgggcagcta tctgatgctg acccactcca cccatgactt
     4441 ctcggaggag acctggcgga acgtcatcca ggtctacaag gagagcggga tctccttcac
     4501 cacccgctcc cagagcgagg tcggggcgtt cttcgacggt ctggagctga tcgacccggg
     4561 tgtgtcggag ccccaccagt ggaagccgga ccccggtgac cgcccggagg ccatccgcag
     4621 cgcggacatc aacatgtggg cgggagtggc ccggaagtcc taggggccca ggccccggga
     4681 ccgggcctca cggcccggtg ccgatcgccc cggtgccgtc gccgaccgtg aagcccagta
     4741 tcgcgccccc gcccgggcgc ggccgggcga agacggtgcc gccgtgcgcg agggcgacct
     4801 cgcgcacgat ggcaagaccc agcccggaac cgggcaggct gcgcgccccg ggggcgcggt
     4861 agaagcggtc gaagacccgc tcgcggtcct ccgcggcgat gcccgggccc cggtccagca
     4921 cctccacccg gcggccgctg atcatcacct cgacgggccc ggtgccgtcc tggtcgaact
     4981 tggcggcgtt ctccaccaga ttggagatcg cgcgctgaag ggtggccggg tggcccgtca
     5041 gacgggtgtc gccactggcc cgtacggtga tctcgcggcc ggtccggcgc cgggcgaggg
     5101 tcacggcggt ggtggccacc tcctccagcg agacctccgt acggggttcg tcgtcccgct
     5161 gcccggccgc cagatccacc agttcgttga cgaggtcggt cagctcccgg gtctcccccg
     5221 ccagatcggc cagcagatcc tcccgcgcgg gccccggcag atcctcgaag cggcgcagca
     5281 gggagatatt ggtgcgcagc gaggtgagcg gggtgcgcag ctcatgcccg gcgtcctgga
     5341 ccagccgccg ctggtcgtcc ttggagcgcg cgagctgtcc gagcatgccg tcgaaggccc
     5401 gtccgaggcg gcccacctcg tcatccccgg cgaccggcac cgccacctcc atccggccgg
     5461 tcgcggccac gctctcggcg acccgggtca gccgcaccag ccgccgggtg atccgcccgg
     5521 ccagccacca gccggccagc ccggccgcga ggatgacggc gaccacgaag agcgcggtgc
     5581 gctgctggag ctcttgcagc agatcctcgg tgtcgctgat ctgctgggcc acctggaccg
     5641 cacccgtgcc gtcgcccacg gccaccgtgg ccatgcggta ctgctccccg ccgatgtcga
     5701 tctcacgccg tacgacggtg ccggccgtgt gggcggcggc ggtcgtccgg tcctcgtcgg
     5761 tcaccggcag cgggggcttg cccgcgtcgt agaccgtgcc ccggccgttg atcacctgga
     5821 cgtccatccg gctgatccgg cgcagatcgt cccgcaggtc gtacgggacg ggcccggtgg
     5881 actccgtggg gtactgccgc aggaccacct tgtcgccgcg gacctggccg cgcagatcgt
     5941 ggatgacgtc gtcgaacgcc gactgctggt ccacccgcac cagcccggcc gccgcgtcat
     6001 agctgagacc gccgaccagg agggtgacta cggtggcggc cgccgagaac gagagcgcga
     6061 aggtggtccg cagactgggc cgcctgcggc ggagccgtgg gagccgcacc atcactcctc
     6121 ccgcagggtg tagccgaccc cgcgcaccgt atggatcagc ggggtgcgcc cctccggatc
     6181 gaccttgcgg cgcagatagc cgatgtagac ggcgaggttc ttcgaacccg ggccgaagtc
     6241 gtagccccag atgcgggcgt agatcgtggc gtggtccagg acgatgcccg cgttgcgcgc
     6301 cagcagctcc agcaggtcga attcggtacg ggtcagctcc agctccgtac cgccgcgcca
     6361 gacccggcgc gccgaggagt ccaggcgcag gtccgagacc tccagcaccc cgtcgatggc
     6421 ggtgtcctcc ggcgcggccg gttcggcggg ggcggcccgg cgcagcagcg cgcgcagccg
     6481 ggcgaagacc tcctcgacct cgaagggctt ggccacatag tcgtcggcgc cggcgtcaag
     6541 accctcgatc cggtcggcgg tctcgacccg cgcggtgagc atgaggatgg gggtgcggtc
     6601 cccttcggcg cgcagcaccc ggcacacctg gagcccgtcc acgcccggca tcatcacatc
     6661 caggaccacc acgtccgggc gctcgcggtg gatggccgcc agcgcctcga tcccgtcggg
     6721 cacgccggtg acgcggtacc cctccagggt cagggcgcgt tccagcgcct ggcggatggc
     6781 acggtcgtcc tcggcgagca gcacggtgtt ggtcacaccc cgagtctgcc aaggccacag
     6841 cggtgcccgt cgcgggcggg ggtcccgagc ggtgcttctt accccgctct caccttcttc
     6901 acgcgacggg cttaccggac ctcggcaagg tgtccgctat gttccggggg gaactcgccc
     6961 cgggaatgca accggccgga gaaaataccg catgaagatc gcattcctgc tgcacaacgc
     7021 ctacgggatc ggcggaacga tccggacgac gatgaacctc gcgacggcgc tcgccgaccg
     7081 tcacgaggtc gagatcgtct cgatgatgcg gcaccgcgag acgccgcgtt tcgccctcga
     7141 cccccgggtg cggctggtcc ccctggtgga cacgcgtcca aacggcgcgg acgcgaagga
     7201 cccgctgttc ttcgaggcca gccgggactt cccggccgcc gagaagcggc accaccagta
     7261 caaccgcctg atcgacaccc gggccgcgga gtatctgcgc gactgccccg ccgatgtgat
     7321 cgtcggcact cggccggggg tgaacgtcta catatcccgc ttcgcccccc gccgtgccct
     7381 gcgcatcgcc caggagcatc tgcggtacga ggcgcacagc aagaagctgc gggcggagct
     7441 ggccccgtac taccggtcgc tggacgccgt ggtcaccacg acggaggcgg acgccgcggt
     7501 ctaccgcgag aagatgccga tgccgggggt gcggaccctc gcgataccca acagcgtccc
     7561 cgaaccggcc gtcgccccct ccgagggcac cgcgccggtg atcgcggcgg ccgggcggct
     7621 ggtccgcggc aaacgcttcg acctgctgat cgacgccttc gcggaggtct cggagaagta
     7681 cccggactgg cggctgcgga tctacggcgg gggcgcagag aaggagcggc tggcggagca
     7741 catcgagcgg ctgggcctgt ccgggagcgc ggagctgatg gggtcctact cccccatcga
     7801 ggcggagttc gcgaaggcgt cgctggtcgc ggtcgcctcg gacgccgagt cgttcgggat
     7861 gacgatcgtg gaggccatgc gctgcggggt gccggtggtg agcaccgact gcccgctggg
     7921 ccccgccgag atcatccggg acggggtcac cgggcggctc gtccccaccg gggacaagca
     7981 cgcgctggcg agcgccctga tggagctgat ggccgacgcc ccggcccggc gggcgatggg
     8041 cgcggccgcc ctggagggct cccggatcta tgaccccgcg ccgatcgccc ggcgctacga
     8101 ccagctcttc gaggagctgc gcgcgagccg gttcgcccgc ggctgggagc gctaccggac
     8161 cgccgcccgc gcccgctggc ggcgcctggc ccgccgcttc ggcatcgccc ccggccgccg
     8221 ccgcaccccg gcggcgggcg agaaggcgag cgcgtaaccc cgggcggggc cgcgtatccg
     8281 gcaccgcgcg gagggacggc gccccggccg agcggggcgc ccgccaggac gccggggagt
     8341 acccggacac cggggcggcg tacgcggatg tcggggcgca cccggatgtc ccggcttacc
     8401 aggaggtccc agcgcaccag gacgtccggg cctaccagga cgtcggggcg tagtccttca
     8461 ggaagcagcc gaagaggtcc tcgcccgcct cgccccggac gatcgggtcg tagacccgcg
     8521 ccgcgccgtc caccaggtcg agcggggcgt ggaagccctc ggccgccagc cgtatcttct
     8581 ccggatgcgg gcgctcgtcg gtgatccatc cggtgtcgac gctcgtcatc aggatggagt
     8641 cggcctcgaa catctcccgt gcgctggtgc gggtcagcat gttcagcgcg gccttggcca
     8701 tattggtgtg cggatggccc gcgcccttgt agccccggcc gaacttgccc tccatcgcgg
     8761 agacgttgac cacgtacttg cgccgggcgg gcgaggccgc catcgccggg cgcaaccggc
     8821 tcaccaggat gaacggcgcc gtctcattgc acagctggac ctcaagcagc tcgaccgggt
     8881 ccacctcgtc aacccgctgc acccaggtgt tggtcgggtc caggtccggc accagcccgc
     8941 ccgcgtcgat cgcggtcccg gcctcgatcc gggccggtga ggcggagccg ctggtgaggg
     9001 cgagggcggt gaggtcctgc ggggtgaggg cgccgtcccg tgccgcgcgg gggcccggca
     9061 gggccgcctg ggcgccgctg ccgaaggcgc cgaggaccag ggactcgggg agctccccgg
     9121 cgggcggcgg cgccgactcg cccgctatca gctcggcgta cgcctggggt gtgcggcgga
     9181 cggtctgggc ggcgttgttg atcagtatgt ccagcgggcc cgcggcgctc acctcgtcgg
     9241 tcagcgcgat gacctgggcg gggtcacgca gatcgatacc gacgaccttg agccggtgca
     9301 gccactccgc gctgtccggc atggccttga agcggcggac ggcgtcgccg gggaagcggg
     9361 tggtgacggt ggtgtgcgcg ccgtcgcgca gcagccgcag cgcgatatac atcccgatct
     9421 tcgcgcggcc gccggtgagc agggcgcggc gcccggtgag atcggtgcgg gcgtcgcggc
     9481 gggcccggtt ctcggcggcg cagtcgcggc acagctggtg gtagaaggcg tcgacctcga
     9541 cataccgggt cttgcagacg tagcaggagc gggggcgcgc caggatgccc gcgatctcgg
     9601 tgctgacgga gctggtgagc gcgaggccca gcgtctcgtc gtcgatccgg tccgcggcgc
     9661 cggtggcggt ggcctcggtg acggccttgt cgttggcggt cttcgcggcc cgccgctcct
     9721 ggcgcctgcg ctgcttcaca ctgcggtaga tcccggaggt ggcccggcgg acggtgatcg
     9781 cgtcggggtg gtcgaccggc agccggtcga gttccgccag cacgctcaga caggtcgcca
     9841 gccgctccgg gtcgatgccc ggcccctcgg ccgtcgcccg ctcggcccgg ccttcgtcag
     9901 tcaccgtcat cgccgctgcc gctttctggt tcgtctgttc ccctggacaa cggcgaaact
     9961 gtacggaagc gggggcgtat gcgccaaacc gtggtccgcg tcaccctcct ccgggcttgc
    10021 ggtacgcata gccgccggtc ggcgccgggg tggccgccgc ggccgggtgt ccggtgtccg
    10081 tcagcgcgcg gatcaccccg tggtcggggg agagcgcaca ggccgggtcg gtacgggtgg
    10141 cgtcgccggt cagggcgtac gcctggcagc ggcagccgcc gaagtcctcc gcgcggcggg
    10201 agcaggtgcg gcacggctcc cgcatccacc cctcgccccg gtagcggttg aaggcgcccg
    10261 agtggtccca gatccactcc agggagtggt cacggacatt gggcgggtcc aggtccggca
    10321 ggctcgcggc ggcggggcag ggcagcgcgg tgccgtcggg cgcgacggtc agcgagaccg
    10381 cgccccagcc gcccatacag ggcttggcga ccccgtcgaa gtagtcgggc acgacccaca
    10441 ccaggtcggt ggccccgccc agccggtccc gccagcgctg gaccgtctcc cgcgcccggg
    10501 cgagctggtc acgggtgggc agcagggcgt cccggttgcg cagcgcccag ccgtagaact
    10561 gggtgttggc cagctcgatc cggtcggcgc cccagtccac gccgcgccgg atgagggcgt
    10621 cgagcgcgtc gaggttgtcg cggtgcagga ccacattgag cccgagcggc agtccggccg
    10681 cgcgcaccag ggcggcggcc cgctccttgg cggcgaaggc gcggtgtccg gcgatccggt
    10741 cggcggcggc cgggtcggcg tgctgcacgg acagctggac gctgcgcagc ccggcggcgg
    10801 tcagcgtggc cagccgggcg ccgtccaggc ccactccgct ggtgacgagc tgggtgtaga
    10861 tcccggcgga ctcggcggcg gtgacgatct ctgccagatc gccgcgcaac agcggctccc
    10921 cgccggagag atgggtgtgc accacgccga actccccggc ctggcgcatc acctccgccc
    10981 actcggcggt ggacagctca cgggagcggc ggaccagctc cagcgggttg gagcagtagg
    11041 ggcagtgcag cgggcagccg tgggtgagct cggcgagcag ggcccagggg cggggcgcgg
    11101 cggtcatcgg acccagccct ccccgcgcat ccggccgagg aaggcgcgca cgtcgtcggc
    11161 cacgggcgcg ccggggaagc ggctttcgag ctccgccacg atggcctcga ggtcgcggtc
    11221 gccgtcgcac agccgcagga tccgcgcggc gctgccgcgc agcaccacca cccgctcggg
    11281 cagcaccagc agatcggcgt cgcgcacccg gtcgtggcgc aggctcaccg cgggggccag
    11341 cgcgggccgc catccggccg gggcgggcgg ggtgccggcg gcggtcatgt cccctccccg
    11401 gggccgtcct tggtgtcggc gtggtccacc gcgtccagca gcgaccacag cacatcgcat
    11461 ttgaaggcga gcgccgccac cgcgcggtcc tcgtcctcgg gggtgcgtgc ccaggtcagg
    11521 acggcgtcga gggcctcggt gctgtcccgg cgcccctggt cgacccggtt gcggaagtag
    11581 gccaggccct cgcgctcgat ccatgggtag taccgctcga aggcgtcgat acgggtgagc
    11641 atgatgccgg gcgcggacag ttcggtgagc gaggcggcga cggcttccag gggcccgcgc
    11701 agccggcaga agttgacata gccgtcgacc gcgagccgca ccccgggcac cacctcctcg
    11761 gccgacagca gccggtcccg gtgcagaccg gcggcctcgc cgagccgcag ccaccgctcg
    11821 ataccgccct cgccttcggt ggtgccgtcg tggtcctgga tgcgccgcag ccacatccgg
    11881 cgcagccgtg gggtgtcgaa tttggcggtg atcagggcgt ccttgacggg gatatggcgc
    11941 tggtagtgga agcggttgag gatccagcgg cgcagttcgg cgggggtgag ctcacccgcg
    12001 tgcatccgta cgttgaaggg gtggcggtcg tggtagcgct cctgcgcgac cgcgcgcagc
    12061 cgctcctcaa gccgtgtgcg tggggtgctc acaggtcgat caccatcccg tcggcggcca
    12121 cctcgacgcc cagcttccgc agctccgtgt ggtgcggcgc ggccgggtcg ttgaggggat
    12181 tggtgttgtt gaggtgggtg tacagcgtgc gtccttcgag cgcggcgagc cgccgcgccg
    12241 tgccgtccgg tccgtcgatc ggcagatgcc ccatggcggt ggcggtgcgc gagccgaagc
    12301 cactgctgag gggctcgtcg tcggaccaga aggtgccgtc gacgatgacg tggtcggcgc
    12361 tctccgcggc gttctggaac gtgtcggacc aggcggcgag cgcgggggcg tagaggaggg
    12421 agcggccggt ggtgcggtcg gtcagccgca gcgcgaccac ccagccgccg tcgtccgggg
    12481 cgtcgagtcc ggccgcgtag cgggggcgtt tggcggagac ggggacggcg ccgacgacga
    12541 ggggcgagtc ctcggcgagc ggccggtcct cggggccgag ggggcgccag tccagccggg
    12601 cgtagggggt gaggacctcg cccaggtgga gtccggtcag cagggcgtgc cgcaccgggg
    12661 cggtggccac gatctcgatg ccgtccgcct cgcgcagccg ggcgatgccg agggtgtggt
    12721 cgagttccgc gtcggtgagg atcaacccgg ccagcggggt gcggcgcggt tcgggcccgg
    12781 ggtgcagttc ggggtggtcc tcgacctggt cgccgaggtc gggggtggcg ttgacgaggt
    12841 accagcggcc ttcggcggcc tggacggcga gcgaggcgtg gcggcggcgc cacccggggt
    12901 gggcgcgtgc cccggagcat ccggggcacg cgcagttcca ctggggtacg ccgccacccg
    12961 ccgcggtgcc gagcacgcgc acgcgcatgg cggggggctc agcgggcgtt cagcgagtag
    13021 gcggtgacct ccagcgcggt ctccacgacc acgtagtcgg gggtctgcca ggcggtctgc
    13081 ccggcgtcgg tgcgggtgcg gtccgccgcc tcgggcgtgg tgcgcggggt ggtgtcgttc
    13141 atggtttcga cctgccttcc atctggtggg aaatcggtcc acaggacgga acggacgggc
    13201 cgtcagcgat ctcggtccat gagggctctc cttcttcgag ctgtgaaggc cgagggaggg
    13261 gatgcgcatg gtgttccgtc tgttgcaggg tcaccagccg tcgggacgtg gtcaagaagc
    13321 gtgcaccaaa aaggtcatcc gacctctgat ggttcgacag ccctgagggc atgaaatcga
    13381 ccacgtggcc gacttcttgg cccgtaccaa tgcttgacgc cccgagagac acctcctacc
    13441 ttccgcgatg caccggcccc ctgctgtcga atctgttgac gcgttagtaa gccttcctta
    13501 ccgttccccg catgtgaacg gggatcagac aggagaacgg gatgaagagg taccggaaca
    13561 ccgccgccgc ggcggccgcc accgcgctcg ccgccggcct gctgatcggg acggccggaa
    13621 cgggaaccgc cgctcccggc cgggccgatt cggctccctc ggacatcaag accgtctcgt
    13681 ccggctggac cgtcccctgg gggctgagct ggctgcccga cggctcggcc ctgttgaccg
    13741 agcgggactc gttcaaggtc tacaagctca cccagtcggg caccaggaca gaggtgggca
    13801 cggtgcccaa tgtggtgacc accgacggtg agggcgggct gctgggcatc gcggtctccc
    13861 cgaactggaa cagcgaccac accatctatc tgatgcacac cgcctccgag ggcaaccgga
    13921 tcgcccggat gacctacgac ggctcctcgc tcggcggcta ccagaccctc gtcaccggca
    13981 tcaagaagaa caagtaccac aacggcggac gcctcaagtt cggcccggac ggctatctct
    14041 acgccaccac cggcgaggcg cagacacccg atctctccca ggacaagaac tcgctcaacg
    14101 ggaagatcct gcgcatgacc acggacggca agcccgcccc gggcaatccg ttcggcacgc
    14161 tcgtctactc ctacggccac cgcaatccgc agggcatcac ctgggacccg cagggccggc
    14221 tgtgggaggc cgagttcggc gacagcaagt acgacgagct caacctcatc gaggcgggca
    14281 agaactacgg ctggccgatc tgcgagggcg agtgctccac cgccgggatg accggcccca
    14341 agcgccagtg gccgaccggc gacgcctcgc ccagcggggt cacctacgcc gacggcgcga
    14401 tgtacctggc ggcgctgcgc ggtgagcggc tgtggcggat cccggtggac gggacgaacg
    14461 cgggcacccc gaaggcgtac tacaccagct cctacgggcg gctgcgcacc gtggagaccg
    14521 tgccgggcaa gaacacgctg tggctgtcca cgacgaacgc cgacagcaac ggcggggagc
    14581 cggacggcgc ggacaaggtg ttccaggtcg agttgaagta gccccgtcgc ggatgggtga
    14641 tgcgtacggt cgcggtccgc cgggccgcga ccgtacgccc gtgtcagtgc gcgagccgct
    14701 cgttcatcag caggaaggcg cccagaccgt ggaggtcgtt cgtattgcgc gcgcggccga
    14761 ggtagtaggc cagatccccg acgttggtgc cctcgctgat atcggtgatg ttcgtcagcc
    14821 cgtcggagcc gaccgacacc ttccgcagca cgccctcata gccccttcgc accgcctcgg
    14881 tgtagccgcc gccgctgatc cagccgtgct ccagggccgc gtgcagcatc agggtgtaca
    14941 tgctggaggc cgaggtctcg gtccagttgc cgggctcgct cgccttgtcg accacctgga
    15001 accagcggcc ggtggccggg tcctggtagc gcgcgaagcc cttcgccagg tgccgtacgt
    15061 tgtcgatcag ttcggcgcgg cgcggatggt cggcggggag cagctccagc acctcgacat
    15121 gggtcatcgc ggtccagccg atggcccggg cccagaagtg ggcggaggtg ccggtggtgg
    15181 ggtcgggctt ccacggggcg tcgccgtcgg cgtcatagcc gtggtagatc agcccgttgg
    15241 ccgccctgag gtggcggaag tacaccgaga ggttcctggt gacctcctcg tacgcgtact
    15301 cctggtcgcc gtaggcgatg ccgtagcgca gcaggaaggg ctgggccatg aagaccccgt
    15361 cgccccacag ttcgttggtc ctgccggtgg cgtgccacat cccgccgtcg gcggtgcgcg
    15421 gataggtggt gatccgggcc cggatctggc cggcggcggt ccggtagcgg gggtcgccgg
    15481 tctcctggtg gaggatcagc agcagattgc cggcctgcat cgcgtcgagg ttgtcgaagg
    15541 tccggctcat atggccgtcg gcgtcgacga agttgtccac ccagcgcttg aggtacgcca
    15601 ggtacgacgg ctcatcgacc cgctggtgga cgcggtaggt gccgagcagg aacagcccct
    15661 ggatgtagcc ccagccgccg agggacgcgg ggtccgggcg gcgggcgatg gtggagtcca
    15721 ccaccgcccg cgaccagtcg gcgggcgccg cgccggcgcc cgccgtcggg aggagaagac
    15781 caccggtgag gcccagtgtg ctcgcgaaca gcgttctgcg actgatcatt cagtcctcct
    15841 tgggtgtcag gacgccttag aggcgccatg tacacgtcaa gactatccgc acacactccg
    15901 taccggaaca aaagcggagg aaaggcgagg atgaggcggg cccgtcaagg ccgaatcccg
    15961 ccaaggtaag gtaagcctga ccttatctat tggagttgct cgtgggcccc cttcgtctgt
    16021 tccccctgct ctcggccgtc ctcgccgcga ccgtcctcac cggctgcgga tcctcggatc
    16081 ccgcgtcgtc atcggcgtct tcggggtcat cggggtcatc ggggtcttcg gggtcttcgg
    16141 cggtctcgaa ggctccgggg tcctccgcgg cggacggtga cttcccgcgc accgtcgccc
    16201 atgagcaggg cagtacgccg ctgaaggccg cgccgaagcg catcgccgcg atcagcaccg
    16261 gacagctcga cgatctgctc accctcggcg tcgtaccggt ggccaccacc cgtgccgact
    16321 acgccggact cgtccccgac tatctgcgca cggccttccc ccggcaggcc gaggcgctcg
    16381 gctcgatgac ggacatcggc acccgcacct cccccaacct ggagaagctg gccgccgcca
    16441 agcccgatct gatcctggtc aacagcaccc agggcgccct ctaccccagc ctggcggcca
    16501 tcgccccgac cgtggtcacc aagggccgcg gggtgaactg gaagaaggac ctgctgaccg
    16561 tcgccgacgc ggtgggcagg cgcgagcggg cccgcaccct gctcacccgc ttcgagaagg
    16621 acgccgccga ccagggcgag aagctgggcg gcgagcacac ggcgctgtcg atggtgcgct
    16681 tcaaccccga ccgggtccgg atgttcggga agaagtcctt caccggcacc atcgccgacg
    16741 acatggggct cggccgcccc gagtcccagc gcttcgacga catctcacag gacctcagcg
    16801 gtgagcggat cccgcagacg gacggcgact ggatcttcta ctccgtccag ggccgccccg
    16861 ggaagaccga cgccgccacc tatctgtcca atccgctgtg gaagaagctg ggcgcggtcc
    16921 gcggcgggca tatcgccaag gtcgacgacg acccctggta tctcaacgcc gggcccaccg
    16981 ccgcccgggt cgtactgcgc gacatcaccg agcacctcgg gcgctgacac cgggcgcccc
    17041 agacggtggc accgggcggc accgggcgcc cccgccgacg gcgggcgtcc cgggcgctga
    17101 ccgcgggcac ctcaggtggc cgaaaccgaa cccctccacg gccgggccga cctctcgacg
    17161 ccccggccac ccgtgtcaac ctccgaccgg cataagccac cgtcacaccc cgtatgcgat
    17221 cgggacaatg cgtcaccaca agtccgtcct caggcaatag tctcggcgta caagccgtgg
    17281 ctgaggaggc acccatgggg accggggatc gtgagcaggc atacgcacgg gcgcggcagg
    17341 aggccgagcg gctcactgcg aacggaatcc agggcatcgc gctgacctgg gtggacaacg
    17401 cgggtctgac ccgggtgaag tccgtgccca ccgcgcggct gccccaggcc gcgcggcgcg
    17461 gggtcgggat gtcccccgtc ttcgacgtct atctcgtgga cgactccatg accaccagcc
    17521 gccatgtcgg cggccccgac ggggatctgc ggctcctccc cgacctggag cggctcaccc
    17581 cactggccgc acagcccggc tgggcctggg ccccggtcga ccggtacgac caggagggcc
    17641 gggcgcaccc cgtctgccag cggctgttcg cccggcggat ggccgagcgg gcacgggagc
    17701 gggggctggc cgtgcgcatg gggttcgaga ccgaatgggt cgtcaccacg ggcgacccgg
    17761 accaggaccc gccgcactac cccaccaccg gccccgccta cggcatggcg cgcctggtcg
    17821 acctcgccga ctatctcgcc gatctgctcg gcgcgctgga cgcacagcac accgaggtgc
    17881 accagctcca tccggagtac tcccccggcc agttcgaggt gtccctggcg cccaccgatc
    17941 cggtggccgc cgccgacctc gccgtgctgg tgcgggagac gatccgggcg tgctccgggc
    18001 gcgccgggct caacccgatg ttcggcccgg tggtggaccc gggcggggtc ggcaacggcg
    18061 cccatctcca tctgagcctg tggcaggggg accgcaatct gtgccgggac ggcgacggac
    18121 cgcacgccat gaccgcgacg gccgaggcgt tcctcgccgg ggtactgcgc gaactgcccg
    18181 ccctgctcgc catcggcgcc ccctcccccg cgagctacct ccggctcgaa ccctcccgct
    18241 gggccggggc gtaccagtgc tggggtctgg agaaccgcga ggccgcggtg cgcttcatca
    18301 ccggcgcacc ggacgacccg ggggccgcca acgccgagat caagtccttc gacccggcgg
    18361 ccaaccccta tctggtggcg ggcgcggtca tcgccgcggg cctaggcggg ctggacgccg
    18421 ggctctccct gccgccgccc gtctccgggg accccgcggt cgaggggcgc gagcggcggc
    18481 tgcccacctc gctgctgacg gcgctcgagc acttcgagga ctcgacggtg ctgcgcgagg
    18541 cgctgggcga tccgctcttc gagtccatcg ccgcggtgcg ccgggcggag gccgccctgt
    18601 tcgagaagtc gtccccgcgt gagatcgcca tcgcgacccg gaggcggtac tgaccgatgg
    18661 aggccgccga gcagacggat ccgaccgagc cgccgctgcc gctcctgcca ccactggtag
    18721 accaccactg ccatggggtg gtccgctccg agctgggctc ggcggcgttc gaggcgttcc
    18781 tgaccgaatc cgacgcgccc gccgcgctcg gcaccacctt cttcgacagc cagctggggt
    18841 tcgcggtgcg ccgctggtgt ccgccgctgc tgggcctcga accgcactgc ccgcccgccc
    18901 actacctcgc ccggcggcgc gagctgggcg cgcgggaggt ggcccggcgg ctgctgagcg
    18961 ccaccgggat cagcgagttc ctggtggaca ccgggctgcc gggcaatctg accacccccc
    19021 aggagctggc cctcgcggcg ggcggcaccg cccatgagat cgtccggctg gagcagttgg
    19081 ccgagcggat cgccgacacc tcgctgaccg ccgacgactt cctgaccggg gtggcggacg
    19141 ggatccggga ggcggcccgt acggcggccg ggttcaaatc ggtggccgcc taccgctacg
    19201 gactggactt cgaacccgat ccgccgggcc ccggcgccgt ccacaccgcc gccgagcgct
    19261 ggctcgcccg gcgcggccag ggcggcaccg ccgccgcccg ggtcaccgac cccgtactgc
    19321 tgcgccatct gctgtggtcg gcggcgtaca ccgggctgcc gctccagctg cacaccggct
    19381 tcggcgaccc cgatctgcga ctggaccgct gcgatccgct cgccctcacc gacttcgtcc
    19441 gggccgtgcg acccacgggc tgcaccctga tcctgctgca cggctatccg taccaccgcg
    19501 gcgccgccta tctggccgcc gtcttcccgc atgtgtacgc cgatgtgggg ttggccctgt
    19561 cgcacaccgg ggcacgggcc ggggccgtgc tcgcggagat gctggagctg gccccgttcg
    19621 gcaaggtgct cttctcgacc gacgcctacg gtctgcccga actgtatgtg gtgggggcgc
    19681 ggctcttccg ggaggcgctg accgggctgc tgacccactg ggtggcggaa ggcgcctggt
    19741 cgcgccgcga cgcccgccgg gtggcggcgc tgctgggcgc ggacaacgcc cgccgcgtct
    19801 acggcctggg caccccggcc ccccgggcgg ggtagccgcc cgcggttccc accgcaccgg
    19861 aacggtccgc cccgcccgtg gcccggagag cgacgggccg ccgccccggg cgggtacggg
    19921 gtcggagggc gcgtcgccgc ggccggggtt cgtgccggat gaggtggcgg ttgccgcctg
    19981 agcccgttcg cacgtcggag tttccggtca ggtggccagg tccagccact ccccgacggc
    20041 cagcacatgt gcgcgccgtc cggcgtgcgt gcggaactcc ttctccgggt cggagacctc
    20101 gacatagccc gcgatcttgt ccggctgctc cggctcgtag tggatcggca ccgcgtaccg
    20161 ggcgtcgagg atctccgcgg ccgctgcggc ctgccgcggg tccaacgcgg cgggcagcgg
    20221 gctcggcggc tgaaggtgcg gtgcgtcgac caccgcgccg ttggcgggca ggaacaccgc
    20281 gtcgaacggg ctgaaccggc gcgcgatgag ccaccagtag ccgtggaaca tcgtgtcgcc
    20341 gccgtggaag acccgctgcc cgtcggcctg caccacccag ttcagctgcg ggtcgccgag
    20401 cccgtcgacg gagggcaccg cggtgacgcg gaacggcccg aattcgcggg tggaccaggc
    20461 atccacgacc tcggcggcca gccggtgcag ggccagttcg cgctcggccg gcagcgtcgt
    20521 cacgttgtcc acgtcgtcac cgtggccggg cgccggtcgc agcaccggcg cccccggcgt
    20581 cagcgcgtcc gcgagcgcgg acgcgtcggt gtggtcccgg tgcaggtggg tgaccagtgc
    20641 ggcggtggcc ctcccgctcg gctccgccag cccctcaccg ggcttccacc ccgtgaacag
    20701 cggtgagagg tcccgtacgt agtcgaccac cagtcgcctg ccgcccgcct cgacctccac
    20761 tccggcccag cccagtcgtc gcacccgcat ctcgcactcc ttcgttccgg tgattgccat
    20821 gcggaactta gcgtacgcac gttcgctaaa tcaatagcga acgcgcgtac gctatccttg
    20881 ccgtatgtca ccacgacgct cagcggccga agcgcaggcc accaggggcc ggatcctcgg
    20941 ccgcgccgcc gagatcgcct ccgaagaagg gctggacggc atcaccatcg gccggctcgc
    21001 cgaggaactg gagatgagca agtccggggt gcacaagcac ttcggcacca aggagacgct
    21061 ccagatctcc acgctggaca aggcgttcgt ggacttctgg caccgggtgg tcgagcccac
    21121 cctgaccgag ccgccgggtc tgcggcggct gcgcgcggtg tgcgccaact ccgtgggcta
    21181 cctggaagcg ccactgctgc ccggcggctg cctgatgacc gcggcgctca ccgaatacga
    21241 cggccgcccg ggccgggtcc gcgacgcggt ggccgaggtg tggtcgcgct ggcgggaaca
    21301 gctgcgggcg gacctgaccg ccgcggtgga gaacggcgag ctgcccgccg gattcgacat
    21361 cgaccaggcg ctgttcgaga tcatcgccgc cggtctggcg ctgaacgcgg ccatgcagct
    21421 ccagcacgac cgggccgccg cgggccgggc ccgccgcgcg atcgaacggg ccctggccca
    21481 gccctgacgc gacccgcccc cgcccggccc ggcagccgac gggccgtcga cacgcgcgcc
    21541 ggagacggcc gccgacgcgg ggcggccaat accggacgcg ggtgacgtcc gggccgaggc
    21601 gccgcgcgcg tcggaggcgg accggggtcc atgcccggcg cggagcgcgt ccgcagtacc
    21661 gtgcccggaa cgtactcgac cgtaaccgga ggagatcgca tgcggatcgg cggcacgacc
    21721 gtcctgctca ccggggccac cggcggcatc gggcggacac tggcccacgc gctcgcggcc
    21781 aagggcgcca agctgctgct caccgggcgc cgcgaggagg tgctgcgccc gctggcggac
    21841 cagctcggcg gccgggcgat cgtcgccgat ctggccgaac ggtccgatgt ggagcgcctc
    21901 gtcgaggagg cgtcggacgc ccggatcctc atcgccaacg ccgcgctgcc ctccagcggc
    21961 ccggtcctgg actaccggcc cgaggagctg gaccgcgccc tcgatgtcaa tctgcgcgcc
    22021 ccgatgctgc tgtcccggct gatggcgccg cacatggtgg agtcggggtc cggtcatctg
    22081 gtgatgatcg gc
//
