GCF_002810005.1 - 7 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_PIJH01000001.1 (Geobacillus thermodenitrificans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor	243,992	264,885

NZ_PIJH01000017.1 (Geobacillus thermodenitrificans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 9.1	terpene	1,037	20,862

NZ_PIJH01000018.1 (Geobacillus thermodenitrificans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	lanthipeptide-class-ii,terpene-precursor	7,622	25,471	High	geobacillin II	ribosomal:RiPP:Lanthipeptide

NZ_PIJH01000003.1 (Geobacillus thermodenitrificans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	T3PKS	180,469	221,536
Region 13.2	betalactone	227,338	251,642	Low	fengycin	NRPS:Type I

NZ_PIJH01000004.1 (Geobacillus thermodenitrificans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 24.1	lanthipeptide-class-i	153,824	180,236	High	geobacillin I	ribosomal:RiPP:Lanthipeptide

NZ_PIJH01000010.1 (Geobacillus thermodenitrificans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 31.1	NRP-metallophore,NRPS	40,579	86,526	High	bacillibactin/bacillibactin E/bacillibactin F	NRPS:Type I

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor	243,992	264,885
Region 9.1	terpene	1,037	20,862
Region 10.1	lanthipeptide-class-ii,terpene-precursor	7,622	25,471	High	geobacillin II	ribosomal:RiPP:Lanthipeptide
Region 13.1	T3PKS	180,469	221,536
Region 13.2	betalactone	227,338	251,642	Low	fengycin	NRPS:Type I
Region 24.1	lanthipeptide-class-i	153,824	180,236	High	geobacillin I	ribosomal:RiPP:Lanthipeptide
Region 31.1	NRP-metallophore,NRPS	40,579	86,526	High	bacillibactin/bacillibactin E/bacillibactin F	NRPS:Type I

No secondary metabolite regions were found in these records:: NZ_PIJH01000002.1 (Geobacillus thermodenitrificans); NZ_PIJH01000011.1 (Geobacillus thermodenitrificans); NZ_PIJH01000012.1 (Geobacillus thermodenitrificans); NZ_PIJH01000013.1 (Geobacillus thermodenitrificans); NZ_PIJH01000014.1 (Geobacillus thermodenitrificans); NZ_PIJH01000015.1 (Geobacillus thermodenitrificans); NZ_PIJH01000016.1 (Geobacillus thermodenitrificans); NZ_PIJH01000019.1 (Geobacillus thermodenitrificans); NZ_PIJH01000020.1 (Geobacillus thermodenitrificans); NZ_PIJH01000021.1 (Geobacillus thermodenitrificans); NZ_PIJH01000022.1 (Geobacillus thermodenitrificans); NZ_PIJH01000023.1 (Geobacillus thermodenitrificans); NZ_PIJH01000024.1 (Geobacillus thermodenitrificans); NZ_PIJH01000025.1 (Geobacillus thermodenitrificans); NZ_PIJH01000026.1 (Geobacillus thermodenitrificans); NZ_PIJH01000027.1 (Geobacillus thermodenitrificans); NZ_PIJH01000028.1 (Geobacillus thermodenitrificans); NZ_PIJH01000029.1 (Geobacillus thermodenitrificans); NZ_PIJH01000030.1 (Geobacillus thermodenitrificans); NZ_PIJH01000031.1 (Geobacillus thermodenitrificans); NZ_PIJH01000005.1 (Geobacillus thermodenitrificans); NZ_PIJH01000006.1 (Geobacillus thermodenitrificans); NZ_PIJH01000007.1 (Geobacillus thermodenitrificans); NZ_PIJH01000008.1 (Geobacillus thermodenitrificans); NZ_PIJH01000009.1 (Geobacillus thermodenitrificans)

Compact view

NZ_PIJH01000001.1 - Region 1 - terpene-precursor

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Location: 243,992 - 264,885 nt. (total: 20,894 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

CV632_RS01405: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

CV632_RS01370: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

CV632_RS01375: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC416

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC416

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

CV632_RS01375: PT_FPPS_like

Domain 1 (34 - 297): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.37 out of 24.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.34 out of 26.06

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.11 out of 24.78

Confidence: medium

Additional weak hits (9):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.03 out of 25.88

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.61 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.82 out of 26.06

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.35 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.73 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.91 out of 30.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.31 out of 30.97

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_PIJH01000017.1 - Region 1 - terpene

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Location: 1,037 - 20,862 nt. (total: 19,826 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

CV632_RS17180: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

CV632_RS17210: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: ligase

CV632_RS17255: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001261.3	0.55	NRPS	AM-toxin	Alternaria alternata
BGC0002173.2	0.47	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0002020.3	0.44	NRPS, saccharide	photolose, oligosaccharide 1 (GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 2 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 3 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 4 (GlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 5 (6-phosphoGlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc)	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002474.2	0.43	NRPS	agrobactin	Agrobacterium tumefaciens
BGC0002493.3	0.42	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002711.2	0.41	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000888.5	0.41	other (other)	bacilysin	Bacillus sp. CS93
BGC0001723.5	0.40	PKS	oviedomycin	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001261.3	0.55	NRPS	AM-toxin	Alternaria alternata
BGC0002173.2	0.47	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0002020.3	0.44	NRPS, saccharide	photolose, oligosaccharide 1 (GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 2 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 3 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 4 (GlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 5 (6-phosphoGlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc)	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002474.2	0.43	NRPS	agrobactin	Agrobacterium tumefaciens
BGC0002493.3	0.42	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002711.2	0.41	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000888.5	0.41	other (other)	bacilysin	Bacillus sp. CS93
BGC0001723.5	0.40	PKS	oviedomycin	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

CV632_RS17220: T2TS

Domain 1 (8 - 611): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.11 out of 27.78

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.71 out of 23.79

Confidence: medium

Additional weak hits (2):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.00 out of 28.14

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.73 out of 31.73

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
ToxT	Regulator of MSHA biosynthesis

NZ_PIJH01000018.1 - Region 1 - lanthipeptide-class-ii,terpene-precursor

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Location: 7,622 - 25,471 nt. (total: 17,850 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

CV632_RS17350: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Ligases: synthetase

CV632_RS17370: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000516.4	2.00	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000554.4	0.46	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000504.5	0.42	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.38	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000527.5	0.38	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000547.5	0.33	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000502.5	0.33	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001311.5	0.32	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0002005.2	0.31	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000525.5	0.30	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000516.4	1.00	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000504.5	0.53	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000527.5	0.51	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000547.5	0.47	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000502.5	0.46	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0002005.2	0.46	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001311.5	0.45	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000525.5	0.45	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CV632_RS17350

CV632_RS18055

Leader:

MEKQEQTFVSKISEEELKKLAGG

Core:

YTEVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

Core with dehydrations:

YDhbEVDhaPQDhaDhbIVCysVDhaLRICysNWDhaLRFCysPDhaFKVKCysPM

antiSMASH-DB 4.0 matches for CV632_RS18055

100.0%

NZ_PIJH01000018.1:

Lanthipeptides: CV632_RS18055_lanthipeptide

1

YTEVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

34

YTEVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

1

YTEVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

34

97.1%

NC_009328.1:

Lanthipeptides: GTNG_RS18990_lanthipeptide

1

YTEVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

34

YTEVSPQSTIVCVSLRICNWSLRFCPSFKV+CPM

1

YTEVSPQSTIVCVSLRICNWSLRFCPSFKVRCPM

34

67.6%

NZ_FOHE01000009.1:

Lanthipeptides: BMX40_RS20255_lanthipeptide

3

EVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

34

EV+PQST+VCVSLR+C WS+++CPSFK KC M

3

EVTPQSTVVCVSLRLCKWSIKYCPSFKRKCWM

34

with 21 more sequence matches

Only the first 10 are displayed here.

67.6%

NZ_JALANL010000003.1and 3 others:

NZ_MUEI01000003.1 Lanthipeptides: BV582_RS23575_lanthipeptideNZ_NIJN01000002.1 Lanthipeptides: CHCC5027_RS22460_lanthipeptideNZ_NIMF01000037.1 Lanthipeptides: CHCC14814_RS22115_lanthipeptide

Lanthipeptides: MOC63_RS03255_lanthipeptide

3

EVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

34

E++PQST+VCVSLRIC WS+++CPSFK KC M

3

EITPQSTVVCVSLRICKWSIKYCPSFKRKCWM

34

64.7%

NZ_CP023481.1and 2 others:

NZ_JALARN010000006.1 Lanthipeptides: MOE03_RS17410_lanthipeptideNZ_JAQCPU010000013.1 Lanthipeptides: PG077_RS20425_lanthipeptide

Lanthipeptides: COP00_RS24795_lanthipeptide

3

EVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

34

E++PQST+VCVSLR+C WS+++CPSFK KC M

3

EITPQSTVVCVSLRVCKWSIKYCPSFKRKCWM

34

64.7%

NZ_JALAJI010000006.1and 3 others:

NZ_JALAOO010000008.1 Lanthipeptides: MOC69_RS16910_lanthipeptideNZ_JALAXE010000008.1 Lanthipeptides: MOF11_RS14910_lanthipeptideNZ_JALAXI010000013.1 Lanthipeptides: MOE73_RS14185_lanthipeptide

Lanthipeptides: MOB90_RS08905_lanthipeptide

3

EVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM

34

E++PQST+VCVSLR+C WS+++CPSFK KC M

3

EITPQSTVVCVSLRLCKWSIKYCPSFKKKCLM

34

42.9%

NZ_CP039297.1and 4 others:

NZ_CP040378.1 Lanthipeptides: D1120_RS00435_lanthipeptideNZ_CP040672.1 Lanthipeptides: FGE23_RS05605_lanthipeptideNZ_CP059318.1 Lanthipeptides: HZT45_RS00565_lanthipeptideNZ_CP087137.1 Lanthipeptides: LOK79_RS00585_lanthipeptide

Lanthipeptides: E4T61_RS00570_lanthipeptide

2

TEVSPQSTIVCVSLRICNWSLRFCPSFKVKC

32

T VSP T+V +R+ SL+ CP+FK+KC

9

TPVSPAPTVV---IRV---SLKVCPTFKIKC

33

41.7%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06300_lanthipeptide

Lanthipeptides: EG886_RS06300_lanthipeptide

3

EVSPQSTIVC-VSLRIC-NWSLRFCPS

27

EV PQS VC V+L +C SL FCP+

2

EVRPQSGPVCAVTLAVCVPVSLAFCPT

28

32.4%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

8

STIVCVSLRICNWSLRFCPSFKVKCP

33

+TI+ VSL +C + C SF CP

10

TTIIPVSLAVCPTTT--CRSFSSPCP

33

29.4%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

3

EVSPQS-TIVCVSLRIC

18

E +P + TIV VSL IC

6

ETTPATPTIVAVSLGIC

22

29.4%

NZ_CP102973.1and 1 other:

NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14420_lanthipeptide

Lanthipeptides: NW963_RS14100_lanthipeptide

3

EVSPQSTIVCVSLRICNWSLRFCPSFKVKC

32

+V+P+ST VC + S++ + K KC

2

DVTPESTTVCAAFASFAGSIQLVKTLKSKC

31

26.5%

NZ_JQBU01000033.1and 1 other:

NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12120_lanthipeptide

Lanthipeptides: IV75_RS14620_lanthipeptide

3

EVSPQSTIVCVSLRICNWSLRFCPSFKVKC

32

+V P+ST +C S+ + K KC

2

DVMPESTPICAGFATLMSSIGLVKTIKGKC

31

23.5%

NZ_CP067069.1and 13 others:

NZ_CP085413.1 Lanthipeptides: LIS80_RS25350_lanthipeptideNZ_JH792105.1 Lanthipeptides: II5_RS26960_lanthipeptideNZ_JH792240.1 Lanthipeptides: IIK_RS26240_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23985_lanthipeptideNZ_NTUF01000024.1 Lanthipeptides: CN379_RS26680_lanthipeptideNZ_NVCZ01000001.1 Lanthipeptides: COK75_RS01180_lanthipeptideNZ_NVDK01000008.1 Lanthipeptides: COK95_RS05665_lanthipeptideNZ_NVEA01000001.1 Lanthipeptides: COL15_RS00010_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08190_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20675_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19560_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14435_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15685_lanthipeptide

Lanthipeptides: JCR32_RS24620_lanthipeptide

2

TEVSPQSTIVCVSLRI-CNWSLRFC

25

++V P++T +CV + I S++ C

1

SDVQPETTPLCVGVIIGITASIKIC

25

MIBiG 4.0 matches for CV632_RS18055

14.7%

BGC0000553.3 (SSGG_RS09925):

Lanthipeptide: SRO15-2212

13

VSLRICNWS

21

VSL +C +S

5

VSLLVCEYS

13

14.7%

BGC0001155.5 (AGY49587.1):

Thiopeptide: GE2270

18

CNWSLRFCPS

27

CN FC S

2

CNCVCGFCCS

11

allorf_25318_25410

Leader:

MSIYQVQLVVKSQKTHSSPFS

Core:

ATSTNPKIC

Core with dehydrations:

ADhbDhaDhbNPKICys

antiSMASH-DB 4.0 matches for allorf_25318_25410

100.0%

NC_009328.1and 1 other:

NZ_PIJH01000018.1 Lanthipeptides: allorf_25318_25410_lanthipeptide

Lanthipeptides: allorf_2195161_2195337_lanthipeptide

1

ATSTNPKIC

9

ATSTNPKIC

1

ATSTNPKIC

9

9.7%

NZ_CP017599.1:

Lanthipeptides: BJP34_RS00845_lanthipeptide

2

TSTNPKIC

9

TSTN +IC

2

TSTNDEIC

9

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

CV632_RS17370: PT_FPPS_like

Domain 1 (52 - 301): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.71 out of 26.33

Confidence: medium

Additional weak hits (3):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.06 out of 39.62

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.17 out of 30.12

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.45 out of 30.12

Confidence: weak

Lanthipeptides

Terpene

TFBS Finder

Core peptide predictions

CV632_RS18055 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3794.9 Da

Molecular weight: 3797.5 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3815.5 Da N = 1; 3833.6 Da N = 2; 3851.6 Da N = 3

allorf_25318_25410 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 879.5 Da

Molecular weight: 880.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 898.0 Da N = 1; 916.0 Da N = 2

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
RpoN	Regulator of nitrogen assimilation and virulence

NZ_PIJH01000003.1 - Region 1 - T3PKS

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Location: 180,469 - 221,536 nt. (total: 41,068 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

CV632_RS08520: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Hydrolases: esterase

CV632_RS08575: thioesterase superfamily protein

smcogs: SMCOG1144: thioesterase superfamily protein

Ligases: synthase

CV632_RS08515: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.55	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002127.3	0.51	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0001238.3	0.51	other (other)	biotin	Aspergillus nidulans
BGC0001962.3	0.50	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001239.3	0.49	other (other)	biotin	Aspergillus nidulans
BGC0000902.4	0.49	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0002403.2	0.48	PKS	β-Diketones	Hordeum vulgare subsp. vulgare
BGC0000285.5	0.44	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.55	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002127.3	0.51	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0001238.3	0.51	other (other)	biotin	Aspergillus nidulans
BGC0001962.3	0.50	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001239.3	0.49	other (other)	biotin	Aspergillus nidulans
BGC0000902.4	0.49	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0002403.2	0.48	PKS	β-Diketones	Hordeum vulgare subsp. vulgare
BGC0000285.5	0.44	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.75 out of 18.57

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.48 out of 20.97

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.15 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.25 out of 20.97

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.77 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.00 out of 27.78

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.10 out of 21.84

Confidence: medium

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 26.86 out of 30.98

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.18 out of 32.93

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.71 out of 18.16

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.21 out of 26.06

Confidence: medium

Additional weak hits (14):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.60 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.60 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.05 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.81 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.83 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.99 out of 26.06

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.88 out of 20.01

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.61 out of 29.38

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.60 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.19 out of 26.06

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.53 out of 36.54

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.65 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.13 out of 26.06

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 3	Repressor of DNA damage response
MexT	Global virulence regulator
MogR	Repressor of flagellar motility genes
NuR	Nickel-responsive regulator
ToxT	Regulator of MSHA biosynthesis

NZ_PIJH01000003.1 - Region 2 - betalactone

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Location: 227,338 - 251,642 nt. (total: 24,305 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CV632_RS08735: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: carboxylase transferase

CV632_RS08745: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

CV632_RS08765: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Lyases: hydratase

CV632_RS08760: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

CV632_RS08710: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

CV632_RS08740: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CV632_RS08755: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.55	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001160.5	0.52	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.52	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000131.5	0.47	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000207.5	0.46	PKS	chartreusin	Streptomyces chartreusis
BGC0000706.3	0.45	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001103.5	0.45	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002405.2	0.45	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0000234.5	0.44	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001095.5	0.43	NRPS	fengycin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.55	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001160.5	0.52	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.52	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000131.5	0.47	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000207.5	0.46	PKS	chartreusin	Streptomyces chartreusis
BGC0000706.3	0.45	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001103.5	0.45	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002405.2	0.45	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0000234.5	0.44	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001095.5	0.43	NRPS	fengycin	Bacillus velezensis FZB42

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.38 out of 25.88

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.16 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.58 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.28 out of 28.19

Confidence: medium

Additional weak hits (6):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.47 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.62 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.18 out of 29.38

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.22 out of 29.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.69 out of 29.65

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
PsrA	Oleic acid responsive regulator
ZuR variant 1	Zinc-responsive repressor

NZ_PIJH01000004.1 - Region 1 - lanthipeptide-class-i

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Location: 153,824 - 180,236 nt. (total: 26,413 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: sulfhydrylase

CV632_RS11815: O-succinylhomoserine sulfhydrylase

smcogs: SMCOG1168: O-succinylhomoserine sulfhydrylase

Hydrolases: amidase

CV632_RS11825: amidase

smcogs: SMCOG1105: amidase

Lyases: cyclase dehydratase

CV632_RS11795: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

CV632_RS11805: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000515.4	1.00	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.60	ribosomal	penisin	Paenibacillus ehimensis
BGC0000538.3	0.59	ribosomal	nisin Z	Lactococcus lactis
BGC0000542.3	0.58	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.58	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000506.4	0.57	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000544.4	0.56	ribosomal	planosporicin	Planomonospora alba
BGC0001789.3	0.56	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000559.4	0.56	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000515.4	1.00	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.60	ribosomal	penisin	Paenibacillus ehimensis
BGC0000538.3	0.59	ribosomal	nisin Z	Lactococcus lactis
BGC0000542.3	0.58	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.58	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000506.4	0.57	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000544.4	0.56	ribosomal	planosporicin	Planomonospora alba
BGC0001789.3	0.56	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000559.4	0.56	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CV632_RS11805

CV632_RS11810

Leader:

MAKFDDFDLDIVVKKQDDVVQPN

Core:

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

Core with dehydrations:

VDhbDhaKDhaLCysDhbPGCysIDhbGVLMCysLDhbQNDhaCysVDhaCysNDhaCysIRCys

antiSMASH-DB 4.0 matches for CV632_RS11810

100.0%

NC_009328.1and 5 others:

NZ_CP014749.1 Lanthipeptides: A0V43_RS19510_lanthipeptideNZ_CP014749.1 Lanthipeptides: A0V43_RS19510_lanthipeptideNZ_CP017690.1 Lanthipeptides: GTID1_RS08690_lanthipeptideNZ_CP017694.1 Lanthipeptides: GD3902_RS07590_lanthipeptideNZ_PIJH01000004.1 Lanthipeptides: CV632_RS11810_lanthipeptide

Lanthipeptides: GTNG_RS18005_lanthipeptide

1

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

33

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

1

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

33

97.0%

NZ_CP014140.1:

Lanthipeptides: ACH33_RS18880_lanthipeptide

1

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

33

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCI+C

1

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIKC

33

93.9%

NC_006510.1and 4 others:

NZ_CP018058.1 Lanthipeptides: GT3921_RS18655_lanthipeptideNZ_CP025074.1 Lanthipeptides: CWI35_RS08795_lanthipeptideNZ_CP027303.2 Lanthipeptides: C1N76_RS05790_lanthipeptideNZ_CP038860.1 Lanthipeptides: E5Z46_RS04660_lanthipeptide

Lanthipeptides: GK_RS18085_lanthipeptide

1

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

33

+TSKSLCTPGCITG+LMCLTQNSCVSCNSCIRC

1

ITSKSLCTPGCITGILMCLTQNSCVSCNSCIRC

33

with 96 more sequence matches

Only the first 10 are displayed here.

93.9%

NZ_CP023704.1:

Lanthipeptides: CQJ30_RS18315_lanthipeptide

1

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

33

VTSKSLCTPGCITG+LMCLTQNSCVSCNSCI+C

1

VTSKSLCTPGCITGILMCLTQNSCVSCNSCIKC

33

69.7%

NZ_AULX01000006.1:

Lanthipeptides: H583_RS0100280_lanthipeptide

1

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

33

+TSKSLCTPGCITGVLMC T+ +S +SCI+C

1

ITSKSLCTPGCITGVLMCFTKGCEIS-HSCIKC

32

66.7%

NZ_LT732548.1:

Lanthipeptides: CZ379_RS19505_lanthipeptide

1

VTSKSLCTPGCITGVLMCLTQNSCVSCNSCIRC

33

+TSKSLCTPGCITGVLMC T+ +S +SC++C

1

ITSKSLCTPGCITGVLMCFTKGCEIS-HSCVKC

32

60.6%

NZ_CP085954.1:

Lanthipeptides: LK411_RS13585_lanthipeptide

1

VTSKSLCTPGCITGVLMCLTQNSCVSCNSC

30

+TSKSLCTPGC TG L C TQN C N C

1

ITSKSLCTPGCPTGALGCFTQN-CDPTNGC

29

51.4%

NZ_CP113114.1and 1 other:

NZ_FZDV01000015.1 Lanthipeptides: CFW84_RS08635_lanthipeptide

Lanthipeptides: OTU45_RS07045_lanthipeptide

1

VTSKSLCTPGCITGVLMCLTQNSCVSCNS

29

+TS SLCTPGC+TGVLMC + +SCN

1

ITSVSLCTPGCVTGVLMC--PGNTISCNG

27

48.5%

NZ_CP021903.1and 20 others:

NZ_CP023409.1 Lanthipeptides: Bateq7PJ16_RS18530_lanthipeptideNZ_CP026036.1 Lanthipeptides: C2H93_RS15000_lanthipeptideNZ_CP028218.1 Lanthipeptides: C7M30_RS14555_lanthipeptideNZ_CP035167.1 Lanthipeptides: EQJ08_RS17140_lanthipeptideNZ_CP035226.1 Lanthipeptides: EQW70_RS18175_lanthipeptideNZ_CP045006.1 Lanthipeptides: F9B13_RS03875_lanthipeptideNZ_CP076083.1 Lanthipeptides: KFF76_RS16710_lanthipeptideNZ_CP079759.1 Lanthipeptides: KXZ66_RS17780_lanthipeptideNZ_CP080508.1 Lanthipeptides: K0V03_RS06525_lanthipeptideNZ_CP089148.1 Lanthipeptides: LRO88_RS19055_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04985_lanthipeptideNZ_JALAVX010000009.1 Lanthipeptides: MOE40_RS09385_lanthipeptideNZ_JAMYDW010000007.1 Lanthipeptides: NHM07_RS16180_lanthipeptideNZ_JAQOXM010000001.1 Lanthipeptides: PO770_RS03875_lanthipeptideNZ_NJRD01000003.1 Lanthipeptides: CE053_RS07200_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18435_lanthipeptideNZ_SORJ01000001.1 Lanthipeptides: BJ795_RS01490_lanthipeptideNZ_VFNF01000001.1 Lanthipeptides: FB592_RS01525_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03850_lanthipeptideNZ_VLJL01000012.1 Lanthipeptides: L604_RS09425_lanthipeptide

Lanthipeptides: CD007_RS17065_lanthipeptide

3

SKSLCTPGCITGVLM-CLTQNSCVSCN

28

S+SLCTPGC+TGVL C Q ++CN

3

SESLCTPGCVTGVLQTCFLQT--ITCN

27

48.5%

NZ_CP116604.1and 2 others:

NZ_JAFFHI010000008.1 Lanthipeptides: JN541_RS08535_lanthipeptideNZ_JAFFHJ010000004.1 Lanthipeptides: JN542_RS06245_lanthipeptide

Lanthipeptides: PHA78_RS04905_lanthipeptide

1

VTSKSLCTPGCITGVLMCLTQNSCVSCN

28

+TS SLCT GCITG +M + VSCN

1

ITSISLCTAGCITGRIMGCHKTPTVSCN

28

48.5%

NZ_GG667191.1and 1 other:

NZ_GG667191.1 Lanthipeptides: HMPREF0298_RS11685_lanthipeptide

Lanthipeptides: HMPREF0298_RS11685_lanthipeptide

1

VTSKSLCTPGCITGVLMCLT

20

+TSKSLCTPGCITG +MC T

1

ITSKSLCTPGCITGWMMCNT

20

45.7%

NZ_JALDTZ010000003.1:

Lanthipeptides: M1F37_RS03135_lanthipeptide

1

VTSKSLCTPGCITGVLMCLTQNSCVSCNS

29

+TS+S CTPGC+TG+LMC + +SCN

1

ITSRSFCTPGCVTGILMC--PGNTISCNG

27

45.5%

NC_015600.1and 14 others:

NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptideNZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptideNZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptideNZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptideNZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptideNZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptideNZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide

Lanthipeptides: SGPB_RS10680_lanthipeptide

1

VTSKSLCTPGCITGVLM

17

VTSKSLCTPGC TG+LM

1

VTSKSLCTPGCKTGILM

17

MIBiG 4.0 matches for CV632_RS11810

38.2%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

1

VTSKSLCTPGCITGVLM

17

+TS SLCTPGC TG LM

1

ITSISLCTPGCKTGALM

17

15.2%

BGC0002144.3 (RCCGEPOP_RS37510):

LAP: phazolicin

23

SCVSCNSCIRC

33

+C C+S RC

2

TCARCDSSSRC

12

12.1%

BGC0002111.3 (multiple genes):

Lanthipeptide: andalusicin A or andalusicin B

14

GVLMCLTQNSC

24

GV N+C

13

GVWASTISNNC

23

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.18 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.09 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.18 out of 20.97

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.67 out of 28.19

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.78 out of 18.16

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.04 out of 26.06

Confidence: medium

Additional weak hits (2):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.48 out of 30.25

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.27 out of 26.85

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

CV632_RS11810 - Class I

Cleavage pHMM score: 17.80

RODEO score: 29

Monoisotopic mass: 3261.5 Da

Molecular weight: 3263.9 Da

Number of bridges: 7

Alternative weights: (assuming N unmodified Ser/Thr residues); 3281.9 Da N = 1; 3300.0 Da N = 2

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 152 - 241; Score: 61.0

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_PIJH01000010.1 - Region 1 - NRP-metallophore,NRPS

Download region GenBank file

Download region SVG

Location: 40,579 - 86,526 nt. (total: 45,948 nt) Show pHMM detection rules used

Region on contig edge.

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

CV632_RS15400: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

CV632_RS15525: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CV632_RS15550: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

Transferases: PPTase aminotransferase

CV632_RS15395: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

CV632_RS15495: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase hydrolase

CV632_RS15465: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

CV632_RS15510: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

CV632_RS15520: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase

CV632_RS15505: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CV632_RS15515: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease

CV632_RS15405: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	1.04	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000401.5	0.93	NRPS	paenibactin	Paenibacillus elgii B69
BGC0000309.5	0.92	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0002695.2	0.88	NRPS	bacillibactin, bacillibactin E, bacillibactin F	Bacillus sp. WMMC1349
BGC0000343.5	0.86	NRPS	enterobactin	Pseudomonas sp. J465
BGC0002075.3	0.85	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.76	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.76	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.75	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.75	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	0.80	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000401.5	0.76	NRPS	paenibactin	Paenibacillus elgii B69
BGC0000309.5	0.76	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0002695.2	0.75	NRPS	bacillibactin, bacillibactin E, bacillibactin F	Bacillus sp. WMMC1349
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.57 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.81 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.23 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.23 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.84 out of 29.38

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

Additional weak hits (13):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.98 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.50 out of 28.14

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.97 out of 25.88

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.31 out of 29.38

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.78 out of 23.43

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.03 out of 31.73

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.47 out of 26.85

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 40578 - 86526:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CV632_RS15505: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (462..860): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FAMTFDIAALELQALVGGETNLYGPTETTIWSTM
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1521..1937): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQIFGGEINMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

CV632_RS15515: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SMSLFPLSSPGGALQVGGAQQVYGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVVNK (97% 8Å match); diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
PerR	Peroxide regulator
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor