LOCUS       NZ_PIJH01000018        17850 bp    DNA     linear   CON 19-FEB-2024
DEFINITION  Geobacillus thermodenitrificans strain JSC_T9a scaffold_17, whole
            genome shotgun sequence.
ACCESSION   NZ_PIJH01000018
VERSION     NZ_PIJH01000018.1
KEYWORDS    WGS; RefSeq.
SOURCE      Geobacillus thermodenitrificans
  ORGANISM  Geobacillus thermodenitrificans
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus.
REFERENCE   1  (bases 1 to 25471)
  AUTHORS   Carlson,C., Singh,N.K., Bibra,M., Sani,R.K. and Venkateswaran,K.
  TITLE     Pervasiveness of UVC254-resistant Geobacillus strains in extreme
            environments
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 25471)
  AUTHORS   Singh,N.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-NOV-2017) Biotechnology and Planetary Protection
            Group, Jet Propulsion Laboratory, California Institute of
            Technology, 4800 Oak Grove Dr., Pasadena, CA 91109, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/19/2024 01:04:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,567
            CDSs (total)                      :: 3,480
            Genes (coding)                    :: 3,412
            CDSs (with protein)               :: 3,412
            Genes (RNA)                       :: 87
            rRNAs                             :: 9, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 6, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 32 of 68
            Pseudo Genes (incomplete)         :: 44 of 68
            Pseudo Genes (internal stop)      :: 21 of 68
            Pseudo Genes (multiple problems)  :: 24 of 68
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:59:54
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7621
            Orig. end                         :: 25471
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            PIJH01000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..17850
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..17850
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-ii"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..17850
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:13081](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13081)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            500..1570
                     /locus_tag="CV632_RS17320"
                     /old_locus_tag="CV632_17345"
     CDS             500..1570
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025386.4"
                     /locus_tag="CV632_RS17320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CV632_17345"
                     /product="DUF4236 domain-containing protein"
                     /protein_id="WP_060476351.1"
                     /transl_table=11
                     /translation="MGLRFRKSVKIAPGVRMNIGKKGVSMSFGGKGLRVNTSSRGVSVS
                     SSIPGTGISYRKQVYSTRKKRPQRTRYEQIKYQQQKEKMLEEARNKVEQYEAHIDMLLT
                     VHEEASDKVHWEKIAISDPPFRIGEEDGPNVRELKKRVEEYKPTWRDRFFNRVEARKRQ
                     MLVHIDQAVREDEEIYESWKENKEIAQKVLANDLQTWRKVIDDAKPFEDIEEMGSRVRY
                     RFDQSRRVIAQLDINNREVVPTKVLTLTKTGKLSEKNMAKGKYLQLYQDYVCSCTLRIA
                     REFFSLLPVQEVVVNVYDESPAEEQYGCILSVVFPREKMDMLDFTNIDCSDTIEQFEHN
                     MKFLKTKGFKLVEEMQ"
     gene            1570..2715
                     /locus_tag="CV632_RS17325"
                     /old_locus_tag="CV632_17350"
     CDS             1570..2715
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009362120.1"
                     /locus_tag="CV632_RS17325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CV632_17350"
                     /product="thermonuclease family protein"
                     /protein_id="WP_020961694.1"
                     /transl_table=11
                     /translation="MKGCLTVILLLLLIALFINYTFFTIGMALAIWGIYEWKINKNLGA
                     KSKKPAIILSIGLILALGSCVGNDDVTTEKEVAVKQEAGKVPNDESKKEKDKKQEEKKD
                     DDKQVKETVNEEQSKSTAATGENQNTEQKESNTEAQKQAQLSSLIKKFGLQAAVVARVV
                     DGDTFELSDGRKVRLIGVNTPESTTRTEEYGKEASNYTKSKLEGKRVYLQKDVSETDRY
                     GRLLRIVWLSVPTDDMNENEIRSKMFNADLVINGYAEPSTYPPDVKYADYFRKFAREAR
                     EANRGLWAYGEYGTTKGDFDPKETEKKSSNSSTNRSSGSSSSSNAKSSSGSSVTSSSSG
                     STEYFKNCTELRKVYPNGVPADHPAYQPRLDRDKDNYACER"
     misc_feature    complement(2753..2767)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.17"
                     /tool="antismash"
     misc_feature    3111..3125
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.45"
                     /tool="antismash"
     gene            3281..3430
                     /locus_tag="CV632_RS17330"
                     /old_locus_tag="CV632_17355"
     CDS             3281..3430
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CV632_RS17330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CV632_17355"
                     /product="hypothetical protein"
                     /protein_id="WP_157807001.1"
                     /transl_table=11
                     /translation="MMVGWWPKTLCQLMAISPEHAPFRPVPAYHIALPEPKDYGSPVLI
                     LLSL"
     gene            complement(3622..3768)
                     /locus_tag="CV632_RS18255"
     CDS             complement(3622..3768)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000471229.1"
                     /locus_tag="CV632_RS18255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_012749539.1"
                     /transl_table=11
                     /translation="MIWVVGLIFFIVTVLSIIFYFKWNDKKYLILGGISLFLTSFVIGY
                     ISS"
     misc_feature    4196..4209
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 20.71"
                     /tool="antismash"
     misc_feature    complement(4400..4413)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     18.15"
                     /tool="antismash"
     gene            complement(4471..6138)
                     /locus_tag="CV632_RS17335"
                     /old_locus_tag="CV632_17360"
     CDS             complement(4471..6138)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007506685.1"
                     /locus_tag="CV632_RS17335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CV632_17360"
                     /product="IS1634 family transposase"
                     /protein_id="WP_172437878.1"
                     /transl_table=11
                     /translation="MYIRRVTRKNKDGTTVAYLQLAHNEWDPKAKYAKAKVIYSFGRED
                     EVDRAVLERLAKSISRFLSPEQAWEIETLTGEVSDDFQFQSSKRLGGAWLLDQLWRQLG
                     LGEILHSLFASRHHQIPLERLIFAMVANRALHPSSKLAMEEWVEKDVHIPHLPQVASHQ
                     LYRAMDELLAVQPELERQVFHAVADLLNLEVDLIYFDTTSSYFEVDPSETPEGESLRKQ
                     GFSKDKRPDLVQIVIGLAVTREGVPIRAWVWPGNTMDMTVIKQVKQDLIGWKLGRVISV
                     MDRGFSSEENLRILQQAGGHYIVGEKMRSGKAAVEEALNRRGRYQQVRENLHIKEIIVG
                     DGEARQRYVLVYNPSEAERQRKERETLLESLKEELEGLRQLPNEAHHKATCRLRSHPSY
                     GKYLRQLKDGTLRIDKQAVREAETYDGKYLIRTSDDTLSAEDVALGYKQLVDIEQAFRT
                     LKSTLELRPMYHRLEDRIRAHVLLSWLALLLVRIVEIRTHESWPKVRDECERLMLGHFS
                     SKNGDLYQRTELTAKQALFLAALGLEPPPKILGIHPRT"
     cand_cluster    6620..17850
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    6620..17850
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[16619:17534](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(16620..17534)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="2"
     gene            complement(6633..7805)
                     /locus_tag="CV632_RS17340"
                     /old_locus_tag="CV632_17365"
     CDS             complement(6633..7805)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008881879.1"
                     /locus_tag="CV632_RS17340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CV632_17365"
                     /product="erythromycin esterase family protein"
                     /protein_id="WP_008881879.1"
                     /transl_table=11
                     /translation="MTTLFVNEVKNQSIDIGDMDRYHFEFLQPILEHKRFVFLGESSHC
                     VKEYSLAKVSLIKYLHEELGFHVLAFESELGPCMIGDYLSDQLDSKRFMAGTIGRVWQN
                     EFVLGLFDYMKKMKQERPLYFTGVDVYQGKKENLFSEFLESYLTGPTKQKFVDFEKRAI
                     EVLIAADKRKIKRSMRQNIREEMESKGMELIEELKQHCFPDSKIYKIVLRTMENRVNYL
                     KATLEKSFSKLFEYRDALMAKNLEFLAQEIYPNEKFIIWAHNMHISKNTSAKRLSAYKS
                     FVENLSQTIKEKSFVLGLYAKEGKMLDYTGKEYPIKKMNKKHLESLLDHSPYQNSFIQC
                     NGNWAQKKWRAYEGGGMPTSFVPAQQYDGILFFKYVSPAYFDVSEKNREE"
     gene            complement(7806..9971)
                     /locus_tag="CV632_RS17345"
                     /old_locus_tag="CV632_17370"
     CDS             complement(7806..9971)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008881880.1"
                     /locus_tag="CV632_RS17345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CV632_17370"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_008881880.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 9.8e-36, bitscore:
                     113.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTKRRVPLKRQIAQTDCAFCCLSMIVAYYKSYVSFHELQERMGG
                     GRDGVSLHALSEIASNIGFNTQVYKRKDLFEVDSPVIVYWDHFHYVVLEKINKRGYHVL
                     DPAIGRCIYSKEEFHKHFTGYYLELKPNNNFKRKKPNNVWLPYLKIAFEKPKLLFSVLI
                     GSMFIQLLTIIMPLLTKFAIDEIVGLNHYEFFYNFLLSIIFLVLINGVIHFLRGRFLAN
                     LRVHLDWKLMSRFFKHLINLPFQYFQMRSFGDILYRANAHIMIRELFSQQTIMSFLDST
                     LILIILGYMAINSPWLTGWVILFGLLNVLLLTLTQNAIKQRSEEELSEQAKFQDAQVET
                     LYGIFGIKMAGVERQVFNQWERLLKNLLSAFKKKEYYSNKINACIVSLELAAPLIILAL
                     SLHQVQLGNITVGTMVAFYSLTGTFFGLVSSLVDTVQSMIMMDTYLHRINDVMEAPTEK
                     IPEKAIKLEKLSGNIRLENVSFSYTKYSRPVLKNISLEIKAGQKVAIVGPSGSGKSTLA
                     RMLLGLYEPNVGEIFYDNVNLKDIDKQWLRRKIGVVPPDATLFNKSILHNISVYEENPS
                     MDDVIEAAKIAQIHDEIMAMPMGYYTPVSEMSMNISGGQKQRIMLARAILQKPAILILD
                     EATSSLDNINEKNIDKHLNEMNCTRIIIAHRLSTIKDADCIIVLNDGKIVESGTHYELM
                     KKKGFYYNLYYSKSNNEELDAVLEGEI"
     gene            complement(10001..13081)
                     /locus_tag="CV632_RS17350"
                     /old_locus_tag="CV632_17375"
     CDS             complement(10001..13081)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008881881.1"
                     /locus_tag="CV632_RS17350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CV632_17375"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_100660692.1"
                     /sec_met_domain="DUF4135 (E-value: 5.1e-123, bitscore:
                     401.4, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.3e-76, bitscore:
                     248.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEIVENNLMEIIKDKLLYPSEKKKEIENNVPINELLFQKKTNKW
                     IDLFYQYLNVCKNNIEVDQLYSNEENLSNPFSSFFKEFLEIASRYLDSSLKSQVNNYDD
                     LSRICNLTSIKNDIMKFIHENLVYVSIRTLIQDLNEEREKGNLIGDTPKERYNFYVDQI
                     LSSPDKKFELIKKYPVLVRILIEFILNKIDSIVESIYRFLKDRSELVHIFHLSDDDILT
                     SLTLQSGDSHNNGRSVIIFQFSSKKKIVYKPRSLSIDLHFQQFLEWINGKKPSLQLKTI
                     TILNKDQYGWQEFVEYKPCSSNNELSRFYERQGNYIAILYILNATDFHFENLIANGEHP
                     VLIDLEGLVQNTVKLPRKASSAYDIAFSKLTDSVLSTGMLPATFMQANIYDFDLSGLGG
                     DEGQPTGLETFTIENPLTDEMRVIKVPAFSQSSKNKPYLKEEKEIAVTDYSSEIIKGFR
                     EMYTLLLHNKKELLSQNGPIYLFKGDKVRIILRSTQVYSTFLDSSFHPDYLKDGYERER
                     LINFLWIGKENHPEYQDAIMYECRDILNGDIPYFYCYTDSSDLYHPIGIVKHNFFYESS
                     FNSLLEKVKMINEEDLNFQIEILTNSLLAQYSNKTHSHANVSNRVYNLDKISGNFRRES
                     FLEVSEKIADNIKENAIFGKENDVTWLGLNLTIEDKWTFKPLDFDLYDGVLGIGLFYAN
                     LYNLNKRKEYKILAEKTVQTALNYLEYYPAKLPLSAFYGYGAYAYVLGNFSIIFNNSEY
                     LTYVKKVLNKAANTIEDDQLLDFLGGAAGLIIVCIHLYKKTGEQYLLDIANKCGELLLR
                     KKEKQAMGIGWRPNQVNKPLAGLAHGSSGFTWALMALYKFTKNYNYKETFLQSFEYEKS
                     LFNKKEENWLVLSDDGDYYGNSMWCHGAAGIGMSRIMMSEYYNSHDLKNDIEIAIRQTL
                     KSGFGGTHCLCHGDLGNLDLFLLASSKFKNEEMKETALKIGEYIASDITYGNLKYGTPS
                     GTKNLGLMLGQAGIGYGFLRLAYPEIVPSVLTLQLNH"
     misc_feature    13152..13172
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.06"
                     /tool="antismash"
     gene            complement(13166..13339)
                     /locus_tag="CV632_RS18055"
     CDS             complement(13166..13339)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038161.1"
                     /locus_tag="CV632_RS18055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class II lanthipeptide, LchA2/BrtA2 family"
                     /protein_id="WP_008881882.1"
                     /transl_table=11
                     /translation="MEKQEQTFVSKISEEELKKLAGGYTEVSPQSTIVCVSLRICNWSL
                     RFCPSFKVKCPM"
     CDS_motif       complement(13271..13339)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKQEQTFVSKISEEELKKLAGG"
                     /locus_tag="CV632_RS18055_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13166..13270)
                     /prepeptide="core"
                     /locus_tag="CV632_RS18055_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.00"
                     /molecular_weight="3797.5"
                     /monoisotopic_mass="3794.9"
                     /core_sequence="YTEVSPQSTIVCVSLRICNWSLRFCPSFKVKCPM"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKQEQTFVSKISEEELKKLAGG"
                     /leader_location="[13270:13339](-)"
                     /alternative_weights="3815.5"
                     /alternative_weights="3833.6"
                     /alternative_weights="3851.6"
     gene            complement(13479..14150)
                     /locus_tag="CV632_RS17355"
                     /old_locus_tag="CV632_17380"
     CDS             complement(13479..14150)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003253283.1"
                     /locus_tag="CV632_RS17355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CV632_17380"
                     /product="response regulator transcription factor"
                     /protein_id="WP_008881883.1"
                     /transl_table=11
                     /translation="MIHILVVDDHRLVGEGTKNMLESEQDFQVELVTSGTEAEQMMEQR
                     TYDVFLLDWRMPDMSGTELSKRILQKQPNAKIVIYTGYDVAPFFNYLIESGITGFVSKT
                     ATSEQLITAIRCALRDEAVIPVHLLRQLQLCEVKARMVENEEHVALSQLEQEILFEVAN
                     GLSNKDIAKKHYISQRSVERHLSRIFTKLHVSSRIEAVEKARQLGLIPELHMLLTPSSD
                     R"
     gene            complement(14176..16440)
                     /locus_tag="CV632_RS17360"
                     /old_locus_tag="CV632_17385"
     CDS             complement(14176..16440)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008881884.1"
                     /locus_tag="CV632_RS17360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CV632_17385"
                     /product="ATP-binding protein"
                     /protein_id="WP_008881884.1"
                     /transl_table=11
                     /translation="MRRTITVISVAAIVALYLTIFNVKHPLIGMDVEKNKNGDIVVSDI
                     YEFGWAKKNGIHINDQVLKVDGKPPLSHFTVRKYKTIEQAKTITIQRENQIQTLTVDYK
                     SHGTEQWLYYIALPMGFFLFAVSLSIFLLRLRPDDKSATVLIYFLLLIGLCYISASLSA
                     KYALFGRQMFNGIFLILPAVFLHFVHHYFEKEKKVWFAKKIVFSLYGFNLVMFVASLIS
                     LSFRSISEAEVLLATFFINMVIILALLGKGFVYLKKDEQQNTVKGLLLAIGLSAAPFVL
                     FYSLPVLIIGKWVLPAELTVTSLFVLPSVFLYLICTDRLFRLQFSINRFVYYAFLSFLP
                     AFLITLLYAKFVNEAWRLVEFALLFLLIYIINILALYLKECFDRTLRAKLYVQKDFYQE
                     SIYRIGETLKKQKNMQEVIRCMEKEVREVLDIENLAFVQLEVKNMQAPFHCDEKEWMKL
                     IKKMDGQPLSIGKIIENKRLFAVFVGSFRQSPLLLIGKKKHPIPFRAEQKDWLSTIVYY
                     ASVTIENMLKVEDFIKELDSLKERSNSVWLTRLIFQWSEKERRKLAIDLHDTILQDLIV
                     LKRKVESLRFQNMRMEEMKKQLNYIEEEIVDMIDLTREICHELRPPFFSQIGLKEAIVQ
                     LIQRFQLRVNIKVELNVHLSAKLKEERELAIYRIIQELLNNALKHSQASYIQLTLEAQN
                     EEVQLHYVDNGIGIDMETLNHCDGKLGLFGIKERVQGLGGTCEMTSQLGEGLDIRITIP
                     L"
     gene            complement(16447..16602)
                     /gene="comX"
                     /locus_tag="CV632_RS17365"
                     /old_locus_tag="CV632_17390"
     CDS             complement(16447..16602)
                     /codon_start=1
                     /gene="comX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020756635.1"
                     /locus_tag="CV632_RS17365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CV632_17390"
                     /product="competence pheromone ComX"
                     /protein_id="WP_008881885.1"
                     /transl_table=11
                     /translation="MQEMIRFLMENPEVIEKLKSGTVSLVGLDELEVQAIIKVFSQSVT
                     PLGYWK"
     gene            complement(16620..17534)
                     /locus_tag="CV632_RS17370"
                     /old_locus_tag="CV632_17395"
     CDS             complement(16620..17534)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008881886.1"
                     /locus_tag="CV632_RS17370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CV632_17395"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_232724476.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.3e-25, bitscore:
                     79.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEKEAVKMQMKEIVTASFSVPSLKESVLTSIEEHTKQSDFLFGR
                     LAGVHYQMFSENMKETERIAASVELMMLAGDMLDDLVDQDSLETTWNKAPLTTSLHIAI
                     GLLLAGQKAIVDLLIDDHKKAKAQLYISSRLLQSVNGQHMDVTYDIQTEAEYIEMVKKK
                     SGSLVAMACFVGTALAGAEKNTVIIEKYANDIGIAAQIENDIDALYRWDEKNDIKAKKK
                     SLPILYMLTSKRDNLLKQYFSNHVDYNELYVQKEKVIQQMEQEGAFYYAKVMSQIYKEK
                     ALQEIEKLDVNDRYKSALKMIIL"
     CDS             complement(17697..17789)
                     /gene="allorf_25318_25410"
                     /locus_tag="allorf_25318_25410"
                     /protein_id="allorf_25318_25410"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSIYQVQLVVKSQKTHSSPFSATSTNPKIC"
     CDS_motif       complement(17727..17789)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSIYQVQLVVKSQKTHSSPFS"
                     /locus_tag="allorf_25318_25410_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(17697..17726)
                     /prepeptide="core"
                     /locus_tag="allorf_25318_25410_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.30"
                     /molecular_weight="880.0"
                     /monoisotopic_mass="879.5"
                     /core_sequence="ATSTNPKIC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSIYQVQLVVKSQKTHSSPFS"
                     /leader_location="[17726:17789](-)"
                     /alternative_weights="898.0"
                     /alternative_weights="916.0"
ORIGIN
        1 tgatgatcag tatctgcagt ttttggctgt tgtgcaggca tacgatcgat acataacgga
       61 aaaacaattc gctaagattg ccattctagc ccaaaaggtg ttcagtaaca attggctgga
      121 cgagctaatt gaaacaacca ggggcatctt gcaacgtaaa gatattcgcg agcccatcgc
      181 ttttctcact tattttttga atgaaaaagt gcagcgcatc caagttggtg tgaaccctaa
      241 tgaagtgaca atccataagg acgtcaaggt cgtcagacgg gaaattgtgc ctgattggct
      301 tcaggactat gaggagaaac tcgctgcaga gagcgccaga agcaaggaat ctgatgaaga
      361 tcttgaacag atgcgtcgtg accttgtgga gaggttgcag aagtataaaa gttaagatga
      421 gagggtgccg gcttttccag gtagagctag gagaagtacg gcacttatca ttataccggg
      481 atgggagggg gctgatgaaa tgggattgcg gtttcgtaaa agtgttaaaa ttgcgccggg
      541 agtcaggatg aatattggta aaaaaggtgt gagtatgtct ttcggaggaa aaggactcag
      601 agtcaatacg agttcgagag gagtttcagt cagtagcagt attccgggca ccgggatttc
      661 ttatcgaaaa caagtataca gcacacggaa aaaaaggcct caacggacgc ggtacgagca
      721 aatcaaatat caacaacaga aagaaaagat gctagaagag gctcgaaaca aggtagaaca
      781 gtatgaggcg catatagata tgttgcttac tgttcatgaa gaagcgagcg acaaagtcca
      841 ctgggagaag attgcaattt cagatccgcc attccgcatt ggtgaagaag atggcccaaa
      901 tgtaagagag ttgaaaaaac gggttgagga gtacaagccg acttggcgag atcgcttttt
      961 taaccgagtt gaagcaagga aacggcaaat gcttgtccac atagaccagg ctgtcaggga
     1021 agatgaggag atttacgaaa gctggaagga aaacaaagag atcgctcaaa aagtgttggc
     1081 caatgactta caaacttggc gtaaagttat cgatgatgct aagccatttg aggatattga
     1141 agaaatgggt agtagagtgc gataccgatt tgaccagtcg agacgtgtca tcgcccagct
     1201 agacatcaat aatcgagaag tcgttcccac aaaggtgctc acattaacta aaacaggtaa
     1261 gctttcggaa aagaacatgg caaaaggaaa gtacttacaa ctttatcaag actacgtttg
     1321 tagttgtaca cttagaatcg ccagggaatt ttttagtctt ctccctgttc aagaggttgt
     1381 cgtcaacgtt tatgatgaat cacctgcgga agagcaatat ggatgcattt tgtctgttgt
     1441 gtttccacga gaaaaaatgg atatgctcga ttttaccaat attgactgtt ctgatacaat
     1501 cgagcaattt gagcacaaca tgaagttttt gaaaacaaaa ggatttaaac tagtagagga
     1561 gatgcagtga tgaaaggctg tttaacagtt attttactgc tccttttgat tgcattgttt
     1621 attaactaca cattttttac aattggcatg gctctggcaa tttggggcat ttacgagtgg
     1681 aaaatcaata aaaatttggg cgctaaatcg aaaaaaccgg ccatcatctt gagtatcggc
     1741 ttgatcttgg cattaggttc ttgcgttgga aacgatgatg tcacaacgga gaaagaggtt
     1801 gccgtcaagc aagaagcagg caaagtgcct aacgatgagt ctaagaagga aaaagacaag
     1861 aaacaggaag agaaaaagga tgatgacaag caagtaaaag aaactgtaaa cgaggagcaa
     1921 tctaagagta cagcggcaac tggagaaaac caaaacaccg agcagaaaga gagtaataca
     1981 gaagctcaaa aacaagctca gctatcaagc ctgattaaaa aatttggatt gcaggcggct
     2041 gttgttgcca gagtggtcga tggcgacacc tttgagttgt cggatggaag gaaagtgcgt
     2101 ttgattggcg taaatactcc tgaatcgaca actagaacag aagagtatgg gaaagaggca
     2161 agcaattata caaaatcaaa actggaagga aaacgagttt atttacaaaa agatgtttca
     2221 gagacggatc gatacggacg gttgcttaga atcgtttggt tgtcggttcc gaccgatgat
     2281 atgaacgaaa atgaaatacg ttcgaaaatg tttaatgccg acttggtaat taatggatat
     2341 gctgaaccgt cgacttatcc gcctgatgtg aaatacgccg attactttag aaagtttgca
     2401 cgggaggctc gtgaggcaaa tcgagggctc tgggcatacg gtgaatacgg tacaacgaaa
     2461 ggagatttcg atccgaaaga aacggaaaag aaatcgtcca attcgtcaac aaaccgttca
     2521 tccggatcga gcagttcatc taacgcaaaa agcagttcag gcagttctgt aacttcctcc
     2581 tcatcaggaa gtacggagta ctttaaaaac tgtacagaac tacgaaaggt ttatccgaat
     2641 ggtgttcctg ctgatcatcc ggcataccaa ccaagactgg acagggacaa agataactat
     2701 gcatgtgaga gataacagcc cttttaaggg ctttttcttt tgtacggaaa cccgcgccgg
     2761 tcttcccggc tggccgcttc ctagcctgcg gctatccagc tggagcctga ggaagcccgg
     2821 cgctcggttc gttcgaagaa gccactcgcg ggtagttcac tcgcagccgt gcggagcagg
     2881 atcggggaag atgatacatc gcaccgctac ttgaagaaat aaatcagaca accaataaag
     2941 ttttactcgt gcaaataatc atttcagaaa ataaataagg aaatatatat atcaacgaat
     3001 aaacgttgat ttcatctttt cttcaattaa ataaatattt acgaatctaa ttccgcgctg
     3061 gtcttcccgg ctggccgctt cctagcctgc ggctatccag ctggagcctg gggaagcccg
     3121 gcgctcggtt cattcaaaga agaagtcgcg cgtaatccag tttcctgcta ctgcccgcgg
     3181 ccgtgcgaag ctgatgcgag gagcgaacca aagcaccgcc gcggtgaata aagatttgca
     3241 ttatttttcg tctgacgtta aatataggtt tgttttcgat gtgatggtcg gctggtggcc
     3301 gaaaacgcta tgccaactga tggccatctc gccggagcac gcgcctttcc ggcctgttcc
     3361 agcctatcac atcgcccttc ccgaaccaaa agactacggg tcgccggtgc tcattttatt
     3421 gagcctctaa tattttttgt ctaaactaat catataatat acattatacg caatttaaaa
     3481 tggcgctttt atgatataat cgcccttctt gatgtttcaa agaggatgat tcctggagaa
     3541 gtttggaatg caacataatc aagattataa gcagtaaatt ccatcgtgtt gcgttcgaac
     3601 agtccataaa acaaaactcc actaactact tatataacca ataacaaaag aggttagaaa
     3661 aagagaaata ccacctaaaa tcagatattt tttgtcattc catttaaaat aaaagataat
     3721 acttaataca gtaacaataa aaaaaatcaa accaacaacc caaatcatct ttctttcccc
     3781 taccccgtta ttctagcaat aaatcctcct actaaatacc ctgctaataa aataataaaa
     3841 gatgccccta cataaaatcc tattctaata aatgtatcct gacggttaac aaaatcgata
     3901 attaaatcca atactttcat attgcccgag ttcgacagtg actaggcaaa caaatcgcct
     3961 cccagccctt gatacagaag ggctgagagg caattgggca tacttctagc gtgtatctag
     4021 gagcgaggat gaatgtctag gatcttcaga ggaggctcca gccctagagc cacagaggtt
     4081 ttcctttgtt tggtcgtgat ctttgtacac tgatagaggt cacgatattt tgaagaaaaa
     4141 tgtcctaacg tggagcgctg acatttgtct cttactttcg gccacgattt tactctcgat
     4201 tcggatcaag aggaggatta gaccgtggag aagcacgtga gcatagatgc aatcctccaa
     4261 ttgatggtac attgacagta accacggtta cccatcgaat gtacatgtct atattataaa
     4321 caaaaaaact ttatattaaa aggattaaat tataaagcgt gtgcctatga aattcggccc
     4381 cgagttcgac agtcactagg caaacaaaat gcctctcgcc ccttgataca aaagggatcg
     4441 gaggcatttg ggcacacttc gggcgtgtat ctaggtgcga gggtggatgc ctagaatctt
     4501 tggaggaggt tccagcccta gagccgcaag gaatagcgct tgtttggccg tcagttcggt
     4561 tcgttgataa aggtcgccgt tttttgaaga aaaatgtcca agcatgagac gctcgcattc
     4621 gtctcttact ttcggccacg attcatgagt tcggatctcc acgatccgaa ccagcaagag
     4681 agccagccaa ctgagcagca catgcgcccg gatacggtct tccaagcgat gatacatggg
     4741 gcgcagctcg agtgttgatt tcaacgtccg aaaggcctgc tcgatatcca ccagttgctt
     4801 atacccgagc gcgacatcct cggcagacaa ggtgtcatcg gaggttcgga tgagatattt
     4861 gccatcgtac gtttccgctt cacgaaccgc ttgcttgtcg atgcgaagcg ttccatcctt
     4921 caattgacgc aagtattttc cgtaggacgg atgggaacgc agccggcagg tggccttatg
     4981 atgagcttca ttggggagtt ggcgaagccc ctccaactcc tctttcagcg attcgagcag
     5041 cgtttcccgt tccttgcgtt ggcgttcggc ttcgctggga ttgtacacga gaacatagcg
     5101 ctgacgcgct tctccgtcgc ccacgatgat ttctttgata tgcaagttct cgcgaacttg
     5161 ttggtagcgc ccgcgacggt ttagggcctc ttcgacggcg gctttgccgg accgcatttt
     5221 ttcgccgaca atgtagtgtc ccccggcctg ttgcaagatt cgcaaattct cttcagacga
     5281 aaatccgcgg tccatcacgc tgatcacacg cccaagcttc cagccaatca agtcttgttt
     5341 cacctgtttg atgaccgtca tatccatcgt attgccaggc catacccaag cgcgaatggg
     5401 gactccttcc cgggtaacgg ccagtccaat gacgatttgg accaaatcgg gacgcttatc
     5461 tttggaaaac ccctgctttc gaagcgattc tccttctggt gtttcggatg gatccacttc
     5521 gaagtacgac gaagtcgtat caaagtaaat caaatcgact tccaggttca ataaatcggc
     5581 cacggcatgg aacacttggc gttccaattc cggctgcaca gccagcagct catccatcgc
     5641 ccggtacaac tggtggctgg cgacttgggg aagatgaggg atatgcacgt ctttctccac
     5701 ccactcctcc atcgccaact tgcttgacgg atgaagggca cgattcgcca ccatggcaaa
     5761 aatcagccgt tccaacggaa tctgatgatg tcgggaggca aacaaggagt ggagaatctc
     5821 tcccaatccc agttgtctcc agagctgatc caaaagccaa gcgccaccaa ggcgtttgct
     5881 tgattgaaac tgaaagtcat ccgacacttc tcctgtcaac gtctcgattt cccaagcctg
     5941 ctcaggagaa aggaatcgcg aaatgctttt ggccagacgc tccaagacag cgcgatccac
     6001 ctcgtcttcg cgcccaaacg aataaatcac cttcgctttc gcatatttgg ccttcggatc
     6061 ccattcgttg tgagcaagct ggagatacgc cacggtcgtt ccatctttgt ttttgcgtgt
     6121 tactcgccgt atgtacatgc ctatattata accgatattc agctgtttta aaagttaaaa
     6181 taaacaagtc gtgtgcctat gaaattcagt gttttttttc taggatccgc atcgcgaaat
     6241 ctttgatata acagcatttt ggccattttc atttgcctaa aatggcctca aaactgtcga
     6301 actcgggtcg gcgttttttc ctaggttaac caccgctaaa cccttgatat aacggcattt
     6361 ctggcatttt catttgccta aaatgggcct caaactgtcg aactcgggat attgaattcc
     6421 tccataaatc tttattattt atacaataac attaacataa gatatcgact atttaaatac
     6481 attattaatt ttattgaacg tgttacaaaa cacataatag atgtattcta gaccaaacaa
     6541 ttctaagtaa tgccacgaca gaatggattt attccaaatt caccttttag ctgaccattc
     6601 cacaatgtca ttgatcattt catagcttca aattactctt ctctgttctt ctcagaaacg
     6661 tcaaagtaag ctggggaaac atatttaaaa aataaaatcc catcatattg ttgtgcaggt
     6721 acaaaggaag taggcattcc tccgccctca taggcccgcc actttttctg tgcccagttt
     6781 ccattgcact gaataaaact attttgataa ggggaatggt caagaaggct ttccaaatgt
     6841 tttttattca ttttttttat tggatattcc ttacctgtat aatccaacat tttgccttcc
     6901 tttgcataca accccaatac aaaacttttc tccttaatcg tttgggagag gttttccaca
     6961 aacgatttat aggcagacag gcgcttggcg gaagtatttt tgctaatatg catgttatgt
     7021 gcccaaatga taaatttttc atttgggtat atttcctgtg ctaaaaattc taggtttttt
     7081 gccattaatg catcccgata ctcaaaaagt ttcgagaaac ttttttctaa agttgctttc
     7141 aagtaattta ctctattttc catcgtacgg aggacaattt tataaatctt gctgtccgga
     7201 aaacaatgct gtttgagttc ctcaatcaat tccatgccct tactttccat ctcttccctt
     7261 atattttggc gcattgaacg cttgattttc cgtttatcgg ctgcaatcaa aacctcgatc
     7321 gcccgctttt caaaatcgac aaacttctgt ttggtcggac ccgttaaata agactcgagg
     7381 aattccgaaa acaaattctc cttttttcct tgataaacat ccacaccagt aaaatacagc
     7441 ggccgctcct gcttcatttt tttcatatag tcaaataatc caaggacaaa ttcattttgc
     7501 cacacacgcc caatggtacc cgccataaaa cgtttagaat caagttgatc agacagataa
     7561 tcgccgatca tacatggccc caattcgctt tcaaaggcaa gtacatgaaa ccccaattct
     7621 tcatgaagat atttaatcag gcttactttt gctagactgt attctttgac gcaatggctg
     7681 ctctccccaa ggaagacaaa gcgtttatgt tccaaaatcg gctgaagaaa ctcaaaatga
     7741 tagcggtcca tatcccctat atcgatactt tgatttttga cttcgtttac aaataaagta
     7801 gtcatttaaa tttcaccttc caaaacggcg tctaattcct cattattact ctttgaataa
     7861 taaagattgt aatagaagcc tttctttttc attaactcgt agtgagtccc cgattcaact
     7921 atttttccat cattcagaac aataatgcaa tccgcatctt taattgtgct taaacggtgc
     7981 gctattataa tacgagtaca attcatttca tttaaatgtt tatcaatatt tttctcatta
     8041 atattatcca atgaacttgt tgcctcatct aatatcaaaa tagcaggttt ttgtagaatg
     8101 gctcttgcta acataattct ttgtttttgg ccacctgata tattcatcga catttcagag
     8161 acaggtgtgt agtaacccat tggcatagcc attatttcgt catgtatttg ggcaattttc
     8221 gcagcttcaa ttacatcatc catagaagga ttttcctcgt aaactgaaat attgtgaaga
     8281 atggatttgt taaaaagagt ggcatctgga gggacaactc caatttttct ccgtaaccac
     8341 tgcttatcta tatcttttaa attaacatta tcataaaata tttcacctac atttggttca
     8401 tataaaccta ataacatccg ggccagtgta cttttacctg atcctgatgg tccaacaatc
     8461 gcaacttttt gccctgcttt tatttcaaga ctgatatttt taagtacggg gcgactatat
     8521 tttgtataag aaaagctaac attttctagt ctaatattgc ctgaaagttt ttctagtttt
     8581 atagctttct ccggtatttt ttctgttgga gcttccatta catcatttat cctatgtaaa
     8641 taagtgtcca tcattatcat gctttgtact gtatcaacta aagaagatac cagtccgaaa
     8701 aaagtccctg ttaatgaata gaatgccacc attgtcccaa cagtaatgtt tccaagttga
     8761 acttggtgta atgataaagc taaaattatt aaaggagcag ccagctccaa actcactatg
     8821 caagcattta ttttattaga ataatattct tttttcttaa atgcacttaa tagatttttt
     8881 aacaagcgct cccactgatt aaaaacttgt cgttctacac cggccatttt gattccaaaa
     8941 ataccatata atgtttcaac ttgtgcatct tgaaatttag cttgttcaga taattcctct
     9001 tcggagcgct gcttaatcgc attttgtgtt aaggttaata ataatacatt caataaccca
     9061 aataaaatta cccatcctgt taaccaaggt gaatttattg ccatatatcc aagtatgata
     9121 agaattaaag tagaatctaa aaaactcatg atggtctgtt gagaaaaaag ttcacgtatc
     9181 attatatggg catttgccct gtatagtata tctccaaatg atctcatttg aaagtactga
     9241 aaaggtaaat taattaaatg tttaaagaac ctgctcatta atttccaatc aagatgaacc
     9301 cttaaattgg ctaaaaaacg gccgcgtaaa aaatggatta ctccattaat taaaaccaga
     9361 aaaataatac tgagaagaaa attgtaaaaa aactcgtaat gatttaagcc aacaatctca
     9421 tctattgcaa attttgtaag taaaggcatt attatagtca gtaattgaat aaacattgac
     9481 ccaattaata ctgaaaataa taatttaggt ttctcaaagg ctatttttag atatggtagc
     9541 caaacattgt tcggtttctt ccttttaaaa ttattgttgg gttttaattc caaataataa
     9601 cctgtgaaat gtttatgaaa ctcctcttta gaataaatgc atcgaccaat agcaggatcc
     9661 aacacatggt atcccctttt atttattttc tctaatacca cataatgaaa gtgatcccaa
     9721 taaacaatca ctggcgaatc aacttcaaat aaatcttttc ttttgtaaac ttgtgtgtta
     9781 aacccaatat tggaagctat ttcggaaagg gcatgcaacg aaactccatc acgaccgcca
     9841 cccattctct cttgtaattc atgaaagctg acatagctct tataataagc aacaatcatc
     9901 gacaagcaac aaaaggcaca atcagtttgt gcaatttgtc ttttaagcgg tactcttctt
     9961 tttgttttca ttaatatatt cctccatata attcctccta ttaatgattt aactgaagag
    10021 ttaaaactga tggaacaatt tccgggtaag caagccttaa aaaaccataa cctattcctg
    10081 cttgtccaag cattaagccc agattttttg taccggaggg agttccatac tttaagtttc
    10141 catatgttat atctgaagca atatattctc cgatttttaa tgccgtctct ttcatttctt
    10201 catttttgaa cttgctagat gctaatagga acaaatctaa attacctaaa tccccatgac
    10261 atagacaatg ggtacccccg aaaccacttt ttaatgtttg cctaattgca atttcaatat
    10321 cattttttaa atcatggcta ttataatatt cactcatcat aattctgctc attccaatgc
    10381 cagcagctcc atggcaccac atcgaattac cataataatc tccatcatca ctcaaaacta
    10441 accaattttc ttccttttta ttaaatagag atttttcata ctcaaaagat tgtaaaaatg
    10501 tttccttgta attataattt ttagtaaact tatagagtgc cattagcgcc caagtaaatc
    10561 ctgaagatcc atgtgcaagt ccagctaaag gtttattaac ttgattaggc cgccatccaa
    10621 tccccattgc ttgtttttct ttttttctta acaataactc tccacactta tttgcaatgt
    10681 ctaataaata ttgttcgcct gtttttttat aaagatgaat gcacactata attaaccctg
    10741 ctgcccctcc tagaaagtcc aataattgat catcttcaat cgtatttgct gccttattta
    10801 aaactttttt tacataagta agatactcgg aattattaaa aataattgaa aaattcccta
    10861 atacatatgc ataggcacca taaccataaa aagcagataa cggtaatttt gctgggtaat
    10921 attccagata attcaaagct gtttgtacag ttttttcagc taaaattttg tattcttttc
    10981 tcttatttaa attatataag ttggcataga acaaacctat tccaagcacg ccatcataca
    11041 aatcaaagtc aaggggttta aatgtccatt tatcctcaat ggtcaaattt aaccccagcc
    11101 atgtaacatc attctctttt ccaaatatcg cattttcttt aatgttgtca gcgatttttt
    11161 cggaaacttc caaaaaactt tcccgtcgga aattgccaga tattttatca agattataaa
    11221 ctctatttga aacatttgca tgactatgag ttttatttga gtattgcgct aatagcgaat
    11281 tcgttaaaat ctctatttga aaattcaaat cttcttcatt tatcattttt actttttcaa
    11341 gcaaactgtt aaaactggat tcataaaaaa aattatgctt gactattcca attggatgat
    11401 ataagtcgct cgaatcagta tagcaataga aatatggtat gtcaccattc aatatatctc
    11461 tacattcata cattattgca tcttggtatt caggatgatt ttctttacca atccataaga
    11521 aatttataag acgctctctt tcataaccat cttttagata atccggatga aaactcgaat
    11581 ctaaaaatgt tgagtatacc tgtgtacttc ttaaaattat ccttactttg tcgcctttaa
    11641 ataaatatat tggaccattt tgcgataata gttctttttt attatggagc aataacgtgt
    11701 acatttctct gaatcctttg atgatttcgg aggaatagtc tgtaactgct atttcttttt
    11761 cttcttttag ataaggttta tttttactac tttgtgaaaa tgctggaact ttaattaccc
    11821 tcatttcatc agttagaggg ttttcaattg taaacgtttc aagaccagtc ggctgtcctt
    11881 catctcctcc taaaccactt aaatcgaaat cataaatatt tgcttgcatg aatgttgccg
    11941 gaagcatacc tgttgataag actgaatcag ttaatttact aaatgcaata tcataggcgg
    12001 aagatgcttt tcgaggtaat ttaacagtgt tctgcactaa tccttcaaga tcaattaaca
    12061 ccggatgctc tccgtttgca attaaattct caaaatggaa atctgtagcg ttcaatatgt
    12121 aaaggatagc aatataatta ccttgccgtt cataaaaacg agataattca ttattagaag
    12181 agcaaggctt gtattcaaca aattcctgcc atccatattg atccttattt aaaattgtta
    12241 ttgtttttaa ttgcaaagaa ggtttcttac catttatcca ttctaaaaat tgctgaaagt
    12301 gcaaatcgat agatagagac ctaggcttat aaactatttt ttttttcgaa gaaaactgaa
    12361 aaataatcac actccttcca ttattatgag aatctcctga ttgtaaagtt aaagaggtta
    12421 atatatcatc atctgataaa tggaatatat gtacaagttc acttctatcc tttaaaaaac
    12481 gataaattga ttctacaata ctatcaattt tatttaaaat aaattcaatt aaaattctta
    12541 ctaaaacagg gtatttttta atgagttcaa actttttgtc tggagatgat aatatttgat
    12601 ccacataaaa attatatctc tccttcggcg tatccccaat tagattacct ttctctcttt
    12661 cttcatttaa atcttgaata agggttctaa tacttacata aaccaaattt tcatgaataa
    12721 atttcataat atcattttta atactagtta agttacatat cctagataaa tcatcataat
    12781 tattaacttg actttttaga ctagaatcca aatatcttga tgctatttct aaaaattctt
    12841 taaaaaaaga agaaaaagga tttgataaat tttcttcgtt tgaatacaat tgatctactt
    12901 ctatattatt tttacaaaca tttaaatatt ggtaaaataa atctatccat ttattagttt
    12961 ttttttgaaa aagtaattca tttattggaa cattattttc tatctccttt ttcttttcag
    13021 agggatataa taatttatct ttaattattt ccatgaggtt attttctact atttcgttca
    13081 tttattacca accctcctta aaaaaatcaa ctaaccaacc caaagagtta cttcaactct
    13141 ttggattggc caaaaatagc aattgctaca tcggacattt tactttgaaa ctaggacaaa
    13201 atcttaagct ccaattgcat attcttaagc taacgcaaac aatcgtactt tgagggctaa
    13261 cctctgtgta accgcctgct aatttcttta attcttcttc agaaattttg cttacaaagg
    13321 tttgttcttg tttttccatt tgtatccctc ccttcatttc aaattatatt cctacttttc
    13381 ttcttcttca ccaccaacat ggtgtcggaa ccccgccatt ttttggcgga gtaccgacat
    13441 gaaatggcgt agtcctaaat aaaaaagaga aaacgccctc accgatccga tgaaggcgtt
    13501 aacaacatat gaagctctgg aataagccct aactgtctgg ctttttctac tgcttctatc
    13561 ctcgaagaca catgtaactt ggtgaagatt cgcgatagat gtctttctac acttcgttgg
    13621 cttatatagt gttttttagc aatatcttta ttgcttaaac cgttggcgac ctcgaataat
    13681 atttcttgct caagctggct cagcgcaaca tgttcttcat tttctaccat cctagctttg
    13741 acttcacaaa gctgcaactg gcgcagtaaa tgcacaggaa taaccgcttc atctcttaac
    13801 gcacagcgaa tcgctgtaat caattgctcg cttgttgccg ttttactgac aaagcctgta
    13861 atgcctgatt caatcaaata attaaaaaaa ggagcaacat catatccggt atatatgaca
    13921 attttcgcat tcggttgttt ttggagaatt cgcttactta attcggtgcc gctcatatcc
    13981 ggcatacgcc aatcaagcaa aaacacatca tatgtacgtt gttccatcat ctgttccgct
    14041 tctgtaccag atgtaacaag ttctacttga aaatcttgtt cgctctcgag catattcttt
    14101 gtcccttcac caacaagacg atgatcatcg acaaccaaaa tgtgaatcat ctagtcattt
    14161 ttctccttac tatgcttata atggaatggt gatccgtata tctagcccct cgccaagttg
    14221 tgacgtcatc tcgcatgttc cacctaagcc ttgcacgcgc tcttttatgc caaacaaacc
    14281 aagcttgcca tcacaatgat ttaatgtttc catgtctata cctataccat tgtcaacgta
    14341 atgaagttga acctcctcat tttgagcctc caatgttagt tgaatatacg atgcctgcga
    14401 atgtttcagc gcattgttta ataattcttg gataatccga taaatagcaa gctcccgttc
    14461 ttccttcaat ttagctgata aatgaacatt caattctact tttatattca cacgtaattg
    14521 gaatcgttgg attaactgta caatcgcttc ctttaatccg atttgactaa aaaatggcgg
    14581 tcttaattca tggcatatct cccttgttaa atcaatcata tctacgattt cttcttcaat
    14641 gtagtttagc tgctttttca tttcttccat acgcatattt tgaaagcgca agctctccac
    14701 tttccgtttt aaaacaatta aatcttgaag aatcgtatcg tgcaagtcaa tggctaactt
    14761 tcttctttcc ttttccgacc attgaaagat caaacgagtg agccaaacag aattgcttct
    14821 ttcctttaag ctgtctaact cttttatgaa atcctctact tttaacatat tttcaatcgt
    14881 gacgctggca taatagacaa tggtggataa ccaatctttt tgttctgccc gaaatggaat
    14941 gggatgtttc ttttttccta ttaatagtaa aggactttgg cggaacgagc ctacaaagac
    15001 cgcaaacaaa cgcttatttt caatgatttt tccaatcgaa agtggttgac catccatctt
    15061 tttgattaac ttcatccact ctttttcatc gcaatgaaaa ggtgcttgca tatttttgac
    15121 ctctaattgt acaaaagcca gattctctat atctaatact tctctcactt ctttttccat
    15181 gcatcggatc acttcttgca tgtttttctg tttttttaat gtttcgccga ttcgatatat
    15241 actttcttgg taaaagtctt tttgtacata taacttagct cttaatgttc gatcgaaaca
    15301 ttcttttaaa tagagagcaa ggatatttat tatataaatt agtaaaaaca acaaagcgaa
    15361 ttcaacaagt ctccacgctt cattgacaaa tttggcataa agcaatgtaa taagaaaagc
    15421 tgggaggaat gataaaaaag catagtacac aaagcgattg atggaaaact gcaatcgaaa
    15481 taaccgatct gtacaaatta aataaagaaa gacagatggc aacacaaaaa gcgaagtaac
    15541 ggttaattca gctggtagta cccattttcc aatgattaga accgggagac tataaaataa
    15601 aacaaatggt gcggcagata gcccaatggc taaaagcaaa cctttgaccg tattttgctg
    15661 ttcatctttt ttaagataaa cgaatccttt tcctaacaaa gccagaatga tgaccatgtt
    15721 gataaaaaat gtagccaata gcacttccgc ttcacttatc gaacgaaacg ataaagatat
    15781 gagtgaggca acgaacatca ctaagttaaa cccataaagg gaaaagacga tttttttcgc
    15841 gaaccacact ttcttttctt tttcaaaata atgatgaacg aagtgcaaaa agacggcagg
    15901 caatattaaa aatataccgt taaacatttg ccttccaaac agtgcatatt tcgctgataa
    15961 gctggcactt atataacaaa gccctatcaa taataaaaag taaataagca cggtggccga
    16021 tttgtcatcc ggccgcagac gaagcaaaaa aatgcttaaa ctaacagcga atagaaaaaa
    16081 acccatcggc aaggcgatat aatacagcca ttgttccgtt ccatgcgatt tatagtcaac
    16141 cgtcaatgtt tggatttgat tttctctctg aatcgttatt gttttcgctt gttcaattgt
    16201 tttgtatttc cggacagtaa aatgggagag cgggggcttt ccgtccactt tcagcacttg
    16261 atcattaata tgaatgccat ttttttttgc ccaaccaaac tcgtaaatat cgcttacaac
    16321 aatatcaccg ttcttatttt tctctacatc catgccgatc aatggatgct tcacattgaa
    16381 aatggttaaa tatagtgcca caatcgcagc tacgcttatc acggtaatcg ttcgtctcat
    16441 cgctctctac ttccaatatc caaggggggt aacggattgg ctaaatacct ttattatcgc
    16501 ttgaacttcg agttcatcta aacctactaa gcttactgta ccacttttta atttttcaat
    16561 aacctctgga ttttccatta aaaaacgaat catttcttgc atatttactc cctccgaaat
    16621 tataaaatta tcatttttag tgcggatttg tacctatcgt ttacatccag tttctcgatt
    16681 tcttgcaaag ccttttcctt gtaaatctgg ctcatcactt ttgcatagta aaacgctcct
    16741 tcctgttcca tttgctgaat cactttttcc ttttggacat aaagctcatt gtaatcaaca
    16801 tgattgctaa aatactgttt cagtaagtta tcccgtttac ttgttagcat gtacaaaatc
    16861 ggaagcgact tcttcttcgc tttgatgtcg ttcttctcat cccaacgata caacgcatcg
    16921 atatcatttt cgatttgtgc agcaattcct atatcattgg catacttttc aatgatgaca
    16981 gtgttttttt cagcgcctgc caatgcagtt ccgacgaaac acgccatggc tactagagaa
    17041 cccgattttt tcttcaccat ttctatatac tccgcttccg tctgtatgtc atatgtgaca
    17101 tccatatgct gcccgtttac gctttgaagc aatcgagatg aaatatataa ctgtgccttt
    17161 gcttttttat gatcatcaat aagtaaatcc acaatagctt tttgtcctgc taacaataac
    17221 cctatggcta tatgaagtga agttgtaaga ggtgctttgt tccacgtggt ttccaagctg
    17281 tcttgatcaa cgaggtcatc gagcatatct cccgccaaca tcatcagttc tacagacgct
    17341 gcgattcgtt cagtttcctt catgttttcg gaaaacatct gataatgcac accagctaag
    17401 cggccgaaca aaaagtcgct ttgttttgtg tgctcctcta ttgatgtcaa taccgactct
    17461 tttaaagacg gtacggaaaa agatgctgta acgatctctt tcatttgcat cttcactgct
    17521 tctttttcga tcatttcagc aacaccttgc ataaaataaa tatttccaaa taggtaaatt
    17581 tcaacaagat ttataaaatt ccttcttcaa atcagtgtaa ttttcaaaac aataacccct
    17641 ttgctttgac aaagagggat tcactatgta ttatctgatg aacatgtttt atccaactaa
    17701 catattttgg gattggtgga agtagcagaa aatggcgaag agtgagtttt ttggctcttc
    17761 accacaagtt gtacttgata tattgacata gaacgcagta ggaaaataaa gaaaatagag
    17821 ggtacaaaaa atgcgaattt tcctgtatgg
//
