LOCUS       NZ_NNBO01000009        22139 bp    DNA     linear   CON 14-AUG-2024
DEFINITION  Kitasatospora sp. CB02891 scaffold9, whole genome shotgun sequence.
ACCESSION   NZ_NNBO01000009
VERSION     NZ_NNBO01000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kitasatospora sp. CB02891
  ORGANISM  Kitasatospora sp. CB02891
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Kitasatospora.
REFERENCE   1  (bases 1 to 346944)
  AUTHORS   Pan,G., Xu,Z., Guo,Z., Ma,M., Yang,D., Zhou,H., Gansemans,Y.,
            Zhu,X., Zhao,L.-X., Jiang,Y., Cheng,J., van Nieuwerburgh,F.,
            Suh,J.W., Duan,Y. and Shen,B.
  TITLE     Discovery of the Leinamycin Family of Natural Products by Mining
            Actinobacterial Genomes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 114 (2017) In press
REFERENCE   2  (bases 1 to 346944)
  AUTHORS   Pan,G., Xu,Z. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUL-2017) Chemistry, The Scripps Research Institute,
            130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 04-APR-2016
            Assembly Method                   :: CLC NGS Cell v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002803145.1-RS_2024_08_14
            Annotation Date                   :: 08/14/2024 03:20:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,223
            CDSs (total)                      :: 7,128
            Genes (coding)                    :: 7,004
            CDSs (with protein)               :: 7,004
            Genes (RNA)                       :: 95
            rRNAs                             :: 8, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 124
            CDSs (without protein)            :: 124
            Pseudo Genes (ambiguous residues) :: 0 of 124
            Pseudo Genes (frameshifted)       :: 32 of 124
            Pseudo Genes (incomplete)         :: 102 of 124
            Pseudo Genes (internal stop)      :: 10 of 124
            Pseudo Genes (multiple problems)  :: 18 of 124
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:31:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 319657
            Orig. end                         :: 341796
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NNBO01000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22139
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="redox-cofactor"
                     /product="triceptide"
                     /region_number="3"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /rules="((cds(PF04055 and (TIGR04085 or SPASM)) and
                     triceptide_precursor) or triceptide_rSAM)"
                     /tool="antismash"
     cand_cluster    1..22139
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /detection_rules="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /kind="chemical_hybrid"
                     /product="redox-cofactor"
                     /product="triceptide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22139
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:12139](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12139)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     protocluster    1..21437
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11437](-)"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(10001..11437)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="2"
     misc_feature    complement(22..37)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.57"
                     /tool="antismash"
     gene            complement(1120..1791)
                     /locus_tag="CG736_RS21815"
                     /old_locus_tag="CG736_21745"
     CDS             complement(1120..1791)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139323.1"
                     /locus_tag="CG736_RS21815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_21745"
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="WP_083462242.1"
                     /transl_table=11
                     /translation="MIDLVTKLVLKPLARAVYRPTIEGLENVPRKGGVILASNHLSFVD
                     SVVIPLAAPRQVFFLAKAEYFTGTGLKGAISRYFFTHVINAVPVERGSVRAATASLEEG
                     LEILDSGRAFGIYPEGTRSLDGRLYRGKTGVAWLALTAGVPVVPVALEGSQHILPVGKR
                     IPRISRITVRFGEPLRFDDLHGQARSAKARRQVTDEVMAAIHALSGQELAEQYNESPKA
                     A"
     misc_feature    1953..1968
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.73"
                     /tool="antismash"
     gene            complement(2027..4207)
                     /locus_tag="CG736_RS21820"
                     /old_locus_tag="CG736_21750"
     CDS             complement(2027..4207)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0047355 - CDP-glycerol
                     glycerophosphotransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF016357.4"
                     /locus_tag="CG736_RS21820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_21750"
                     /product="bifunctional
                     glycosyltransferase/CDP-glycerol:glycerophosphate
                     glycerophosphotransferase"
                     /protein_id="WP_100587867.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 6.7e-28,
                     bitscore: 91.9, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPLLSIVLPVHGVERFLPQCLESLRSDGAAPGEVELIAVDDRSP
                     DRSGALLDAHAATDPRMRVLHLAENQGLGGARTAGLAEATGTYVWFVDSDDWLPDGTID
                     AVLAELRAETTRDLPADVLLTDFTHVYHDGGEEPNPWRHVLAGSPLVSGCTAAEHPALF
                     NSVLAVWNKIMRRQYLLDLDVHFGRGYYEDISVTYPLLLAADRLVYLDRPCYRYRRGRP
                     GAITATASAKHADAFAQYDAIFAFLDRDERANRLRTLVFDRTVKQALTVYDTPGLVPVE
                     LRAEFFARITGHFARHRPAGYRFPSGVRGIQYRLAARGSRRAYAELRRGGRLPGAVKRG
                     TKAVAPGVKKAMRSSARFTAYNAFRRLPVDEHLAVYAAYWHRGYACNPAAIYEKARELA
                     PQVRGVWVVENAARAATLPEGVPYVIVNTPAYLKAMATAKYFVNNVNFPHTMAKRTGTV
                     HVQTQHGTPLKAMGMDLREHPVAADGMDFERLREAVARWDYLVSPNPHTSEHFARAFPG
                     TYQTLDTGYPRNDRLVHATTEECATVRRELGIAPGQRTVLYAPTHRESRGGYLPLLDLP
                     ALAERLGSGWTVMVRTHYFHDGGAGDLAARPGSARLLDVSDHPSVEDLYLAADTLVTDY
                     SSMMFDYAVLDRPIAVYAPDWEEYQQVRGVYFDLMKEPPGAVATEQDALVEALLAGDPE
                     PAARQRFRERFCPWDDGRAAERVVSRIFPVRR"
     misc_feature    4661..4675
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.24"
                     /tool="antismash"
     misc_feature    complement(4665..4679)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.67"
                     /tool="antismash"
     misc_feature    complement(4909..4919)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            5029..5298
                     /locus_tag="CG736_RS21825"
                     /old_locus_tag="CG736_21755"
     CDS             5029..5298
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005319372.1"
                     /locus_tag="CG736_RS21825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_21755"
                     /product="hypothetical protein"
                     /protein_id="WP_100587868.1"
                     /transl_table=11
                     /translation="MEQMQVRTRPRVPAIQCGVGATGRRIDRHLAVLGAPALSTVDTAE
                     ALGLIRELTPRGPSVPVAVPRRSVRVSLMAPLRRLKRSMFGSRG"
     gene            5512..5934
                     /locus_tag="CG736_RS21830"
                     /old_locus_tag="CG736_21760"
     CDS             5512..5934
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141612.1"
                     /locus_tag="CG736_RS21830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_21760"
                     /product="secondary thiamine-phosphate synthase enzyme
                     YjbQ"
                     /protein_id="WP_043911095.1"
                     /transl_table=11
                     /translation="MSDTFHTTTLDVTTGRREVALDITDRCHDFLRDVTGGRDGLLNVF
                     VPHATAGIAVIETGSGSDDDLLSTLRELLPADDRWRHRHGSPGHGRDHVLPGLVAPHAT
                     LPVVGGRLALGIWQSVVLIDTNGDNPDRTLRLSFLG"
     gene            complement(5983..9015)
                     /locus_tag="CG736_RS21835"
                     /old_locus_tag="CG736_21765"
     CDS             complement(5983..9015)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037833.4"
                     /locus_tag="CG736_RS21835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_21765"
                     /product="choice-of-anchor D domain-containing protein"
                     /protein_id="WP_100587869.1"
                     /transl_table=11
                     /translation="MTQNVVAHDPTVSMNPMRTGWDPHQPQLAPSKVSAGDFGQLFSTP
                     VDGQVYAQPLVIGSTVVVATENNNVYGIHAVTGAVLWSKSLGPAWPAAAIGCGDLIPNI
                     GVTSTPVFDPSSGRVYLTAKVNDGPDTKHPHWFLHSLDVATGHEAAGWPVTIQGSPVNN
                     PGNTFNPFTAQQRPGLLLLDGEVFAGFASHCDVKPYVGYVVGVNTATRALRMWSTENAA
                     SDTEAGVWMGGGGLVSDGPGRIFFSTGNGVSPAPGPGKQPPGHLAESVVHLSSGGQLTA
                     VDFFSPGNADNLDLNDQDLGSGGPVALPSPPFGTAAHPKLLVQIGKDGRVFLLDRDDLG
                     GRSQGPGGSDQALSIGGPFRGIWGHPAVWGGDGGFVYVPENDGHLRALRFGVDGAGTPV
                     LTNAGSSSAAIGHYPGSPVVTSDGTTSGSALVWIVCPDPNGSDGVNAQLRAYDAVPVNG
                     VLKLRWSAPMGTAVKFSKVAVGEGRVYVGTRGGHLVAFGSPSQAALTGSPVDLGQVAVG
                     ATGNATATVTATRSVTVTAITTTAPFSVTPPTLPVTLNTGGTLAVPVGFAPTGPGGATA
                     TLSFAVTTNGVADTVGIDLNGTGTQPGFAASPPSLDFGQLPTQSSMTLGVSVTNTGTAT
                     ETIAGATPSSPPFTVTGLPAAGATLAPGASIAVSVTYAPTVASPAGGDSSQFVVTGADG
                     HSVTVPLTGTAVVGAPHLTISPASLDFGQVAVGGSLGRTFDITNTGNLVLTITKAAPPT
                     APFAAPDPIAEGQKLGPGQVVHQAVVFSPTAAGAASGQFVITGDDGQGKQPVPFTGTGV
                     TSGSLSQPSTGSWTFNGTAVLSNTDIVLTEAINGQTGSALNDMTVPSANLRAHFTAVIG
                     GGSGADGLAFVLLDAAHETPHSLGGGGGGLGYSGLHGLAVTLDTSQNANDPSANFVGLA
                     TGGNGDALTYAATATDIGDLRTGTHAVDVQVTGGRVQVTVDGKAAIDATVAVPAAVLVG
                     FTGATGGLDDNHRVQGVSITF"
     gene            complement(9091..9981)
                     /gene="pqqB"
                     /locus_tag="CG736_RS21840"
                     /old_locus_tag="CG736_21770"
     CDS             complement(9091..9981)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962380.1"
                     /locus_tag="CG736_RS21840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_21770"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_100587870.1"
                     /transl_table=11
                     /translation="MRLRVLGTAAGGGLPQWNCACPTCARARTAGPGAWRTQECLAVGV
                     SDDAWYLVNASPDLRVQLLAAPGLTPPDGTRRTPLRGVLLTDGELDHTTGLLALREGAE
                     LDVHAPPPVWRSLGEVLPLRGLLACYGASRWHPLDRPLRLDGGLTVDAFPVSDKRPRYA
                     AHFDAPGPWTVAYRFTDTRTGARAVYAPSLADWPDGFDAFLDGADCLLLDGTFWSDEEL
                     RHVSGERRTARAFGHLPIAGPDGTLRRLRSHPGTRRLYTHLNNTNPLTDPDSDRHEELA
                     AEGVEVAGDGMELQL"
     gene            complement(10001..11437)
                     /gene="pqqE"
                     /locus_tag="CG736_RS21845"
                     /old_locus_tag="CG736_21775"
     CDS             complement(10001..11437)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_rSAM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR02109.1"
                     /locus_tag="CG736_RS21845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_21775"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_198520571.1"
                     /sec_met_domain="PqqD_RRE (E-value: 2e-16, bitscore: 53.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1e-07, bitscore: 26.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 8.9e-21, bitscore: 69.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 8.9e-07, bitscore: 23.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.4e-11, bitscore:
                     37.3, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.2e-10, bitscore: 34.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="triceptide_rSAM (E-value: 1.0, bitscore:
                     1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADEEGPWRLRRGVRLGHDQVRSVPVLLHPEGVLVLGGTAAAVL
                     ARCDGATGTTAILAELERQYTGVRPAEVRSFLASLAEQCLLEAGPTDPPRPPTVPGTPA
                     VRETPESPGTPEAQDGARPDRPFGLLAELTYRCPLRCAYCSNPVALDEYADELSPAEWR
                     RVLTEARALGVLQVHLSGGEPLLRRDLPALVAHARGLGLYTNLITGGQSLSPARLAGLA
                     AAGLDHVQLSFQDATAAPADALAGRPVHARKLAAARLVRAAGLALTVNVVLHRRNIERV
                     PALIDLAAELGADRLELANTQYYGWALRNRAALLPTRAQLAAAEAAVTAARERLAGVLQ
                     IVYVVSDHHETWPKPCMNGWASRQLTVAPNGDVLPCPAAAQIPGLGVTGVRDRPLADIW
                     FDSPAFTRFRGTDWMPEPCRSCERKELDHGGCRCQAFQLTGDPAATDPVCRLSPHHALV
                     TRLVRDGESAPTVPLVPRGA"
     aSDomain        complement(11177..11413)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CG736_RS21845_PqqD_RRE.1"
                     /evalue="1.90E-17"
                     /identifier="RREFam006.1"
                     /label="CG736_RS21845"
                     /locus_tag="CG736_RS21845"
                     /protein_end="87"
                     /protein_start="8"
                     /score="53.8"
                     /tool="antismash"
                     /translation="WRLRRGVRLGHDQVRSVPVLLHPEGVLVLGGTAAAVLARCDGATG
                     TTAILAELERQYTGVRPAEVRSFLASLAEQCLLE"
     gene            complement(11441..12139)
                     /gene="pqqC"
                     /locus_tag="CG736_RS21850"
                     /old_locus_tag="CG736_21780"
     CDS             complement(11441..12139)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010357437.1"
                     /locus_tag="CG736_RS21850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_21780"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_100587871.1"
                     /sec_met_domain="TIGR02111 (E-value: 4.8e-83, bitscore:
                     272.3, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRTARTVPEFTAALQAHSESYWDNHPFHLRLHQGGLSEPELRS
                     WIANRWYYQKWLPQKDAAVIANCPVPEVRRRWVKRLADQDGTAPDRGGNVDWLALAEAA
                     GLGRAEVLDERHVLPGVRFATDAYVNFARTRPWIEAVAASLTELFSPGLMRDRLTALRT
                     HYGWVEPAGLRYFEQRPAVADADSAHALGLVTEYCTSREQQDAALAALAFKCDVLWSML
                     DAIEHAAAAG"
     gene            complement(12149..12331)
                     /locus_tag="CG736_RS21855"
                     /old_locus_tag="CG736_21785"
     CDS             complement(12149..12331)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CG736_RS21855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CG736_21785"
                     /product="hypothetical protein"
                     /protein_id="WP_100587872.1"
                     /transl_table=11
                     /translation="MTNRPNTAAPSPHLPAGPADPPRPAPSGPPPRPDVRRAWSPPDAQ
                     SIELAHEVTAYAGRR"
     gene            12460..12681
                     /locus_tag="CG736_RS21860"
                     /old_locus_tag="CG736_21790"
     CDS             12460..12681
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133761.1"
                     /locus_tag="CG736_RS21860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_21790"
                     /product="hypothetical protein"
                     /protein_id="WP_100587873.1"
                     /transl_table=11
                     /translation="MAEQQSETRGAEQICEVSADPEQARRGLRPGGPGERAACVLCGGE
                     TEYPAETPGSTLCPVCTWQQAQRGACSG"
     misc_feature    12684..12698
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.16"
                     /tool="antismash"
     gene            12704..13531
                     /locus_tag="CG736_RS21865"
                     /old_locus_tag="CG736_21795"
     CDS             12704..13531
                     /NRPS_PKS="Domain: Abhydrolase_1 (60-250). E-value:
                     3.5e-17. Score: 54.7. Matches aSDomain:
                     nrpspksdomains_CG736_RS21865_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012770.4"
                     /locus_tag="CG736_RS21865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_21795"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_100587874.1"
                     /sec_met_domain="PF00561 (E-value: 8.3e-14, bitscore: 46.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVFVPSAGPAAGRLERPDATLAFETTGSAGPLAVHAHGSLSSRA
                     HEQRAGLFDWTPLTATHRLARYDARGHGRSTGRPVAADYSYPALAADLLALCDHLSPDA
                     PVTGLGASMGTATVLWAALARPERFDRLVLAVPAVAWAAREPRRAGLRAAATLVERRGT
                     GTLRAAAKFSGPPAVLAEAPQYATEFDAVEDLVPAVLRAAADADLPTPDRLRDLPHPTL
                     ILAWPTDPVHPLATARTLAEHLPNARLHTATTLADVRSWGRLAADFLAGRRHG"
     aSDomain        12884..13453
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CG736_RS21865_Abhydrolase_1.1"
                     /evalue="3.50E-17"
                     /label="CG736_RS21865_Abhydrolase_1.1"
                     /locus_tag="CG736_RS21865"
                     /protein_end="250"
                     /protein_start="60"
                     /score="54.7"
                     /tool="antismash"
                     /translation="THRLARYDARGHGRSTGRPVAADYSYPALAADLLALCDHLSPDAP
                     VTGLGASMGTATVLWAALARPERFDRLVLAVPAVAWAAREPRRAGLRAAATLVERRGTG
                     TLRAAAKFSGPPAVLAEAPQYATEFDAVEDLVPAVLRAAADADLPTPDRLRDLPHPTLI
                     LAWPTDPVHPLATARTLAEHLPNARLH"
     gene            complement(13561..16587)
                     /locus_tag="CG736_RS21870"
                     /old_locus_tag="CG736_21800"
     CDS             complement(13561..16587)
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006302 - double-strand break repair
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1218: Exonuclease"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543309.1"
                     /locus_tag="CG736_RS21870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_21800"
                     /product="AAA family ATPase"
                     /protein_id="WP_100587875.1"
                     /transl_table=11
                     /translation="MRLHQLTVTAFGPFASTERIDFDRLTASGLFLLRGATGAGKSSVL
                     DAVCYALYGELPGSRRSNGVRSDHADQGRRTEVVLEATLGGRRLEITRSPEQLRPKKRG
                     SGFTADKAQTLLREWAADAGEGEPGWVAVSKSHQEAGEELTRLLGMSRDQFCQVVLLPQ
                     GDFARFLRADSKQRADLLGKLFDTGRFDQLERWTAERRLRQEHEVQAGRQKLRDLAARA
                     EEAAGPLAADAAAHRPDENASAADVLAWAAMLRGTAAERVTATALALESAEAARTRART
                     RLDAQRTLADRQHRHRSAQQDHLRLAGADRESAPDRARLRLALAAGALSPLRTLHQGAL
                     AAHAAATAAESAHRVTLTARAAAPWAVQLLGDLEPTAAERTLRTEATRLAEARADEQRH
                     SRLLVERDELAAEQKRADDLAEESQDWLSGFDDQLKQLTVDLDAARDAHALLARLDSRH
                     QELTARQEAARRHRSLRAALSAAEARVRTLTDAALDARARTLDLQERRLAGMAAELAAQ
                     LADGEPCRVCGSPEHPAPARPSADQVTAADEQRARAAQHAAEAELDAAKHRLGTLQVDA
                     AAAETAAAGRSVAELTAILDELTAERREALHTAERLVPLGQQVERLEQERRARHERLRQ
                     AGERGAVLADRLGTVAAELDTLAGRIAAARGDAPSVAARAAAVDALAAAVTAVLDAART
                     TAETTHRRAEATGALERAAADAGFADLSALAAAELPAHRRDALQRQFEQLDAALEQAAA
                     RLADPELRAAAELPSAEPEFAHAAEEHATAVLRAADTAHRTADDRVAALARITRDLTAL
                     ADAFAPVLDAYARISRLAALLAGAPAENALRMRLESYVLAARLEQVAAAASQRLLKMSG
                     GRYTLVHSDGLVSGTKRSGLSLHVVDAWTGRERDTATLSGGESFFASLALALGLADVVT
                     DEAGGMPLDTLFIDEGFGTLDENTLEEVMDVLDSLRERDRAVGIVSHVADLRTRIPAQL
                     LVRKHRHGSTVHHTTRDDA"
     gene            complement(16610..17782)
                     /locus_tag="CG736_RS21875"
                     /old_locus_tag="CG736_21805"
     CDS             complement(16610..17782)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1230: Nuclease SbcCD,
                     D subunit"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139334.1"
                     /locus_tag="CG736_RS21875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_21805"
                     /product="exonuclease SbcCD subunit D"
                     /protein_id="WP_100587876.1"
                     /transl_table=11
                     /translation="MRLLHTSDWHLGRSFHRENLHEAQRAFLDHLVATAVAERVDAVLV
                     AGDVYDRALPGLEAVALFDDVLWRLAERNIPTVFISGNHDSARRLGVASRLIERAGIHL
                     RTDPGTLAEPVLLADGHGPVAVYGLPYLEPALVRDRLGLAKGGHEQVLAAAMDAVRADL
                     AARPAGTRAVVLAHAFVTGGEQSDSERDIAVGGVQSVPAGVFDGVHYVALGHLHGCQTL
                     APHLRYSGSPLAYSFSETTHRKSMWLVDLDAEGAVEATRILCPQPRRLAQLRGRLDELL
                     TADEHEWAEGAWVQATLTDPVRPVDPMERLRVRFPHTLQLLFEPEGGEQAASGSYAQRV
                     SGRSDREVVEGFVAHVRPGRELDDTEQSWLLEGLEAVRRTAADRAEENGR"
     gene            18011..18604
                     /locus_tag="CG736_RS21880"
                     /old_locus_tag="CG736_21810"
     CDS             18011..18604
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CG736_RS21880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CG736_21810"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_198520572.1"
                     /transl_table=11
                     /translation="MGIEYSPEISELLGRVRRRPNAGWPWHAGSAVPEGLPVKQSWGWL
                     FAPDGRVLTLVNPRDGVVSLPGGSLEAEDAGDPGATLARESAEEAQALIGPPVYLGYLY
                     DRVGSANGGHECARVRMAAALHGVARSAPDPASGRHYRRLLVAPGLAVELLGWGAAGLQ
                     QARAAVAAAVGVLGVPASANETIEELPLGGCWLR"
     gene            18694..19302
                     /locus_tag="CG736_RS21885"
                     /old_locus_tag="CG736_21815"
     CDS             18694..19302
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016430504.1"
                     /locus_tag="CG736_RS21885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_21815"
                     /product="TIGR03086 family metal-binding protein"
                     /protein_id="WP_100587877.1"
                     /transl_table=11
                     /translation="MTDIQEFDARALKVTQTVVDRVAADRLDRPTPCGDWTLGQLLAHM
                     TGQNHGFAFAAGGELHGREVWRDRPVGDDPGEEFAASAAAVVAAFGEEGVPEREFWLPE
                     VRGGQWFPAVQAVGFHLVDYVVHGWDVAASIGVGIEFDADVLAAALTVAEAVPTGASRE
                     REGAAFAPALDVPAGASVLDRILLLLGRDPNWSAPGHTG"
     gene            complement(19391..19819)
                     /locus_tag="CG736_RS21890"
                     /old_locus_tag="CG736_21820"
     CDS             complement(19391..19819)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CG736_RS21890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CG736_21820"
                     /product="hypothetical protein"
                     /protein_id="WP_157815690.1"
                     /transl_table=11
                     /translation="MNKTIRGAAKAAVAVTAAAAAVLGATGSASATSSQGIIPGQSLNV
                     GDSIVSPSGVYQLILQSDGNLVEYRGSGSGRTVCWATGTNGSAAHHASYQSDGNFVLYT
                     QYGTALWSSNSAGTAAISVVIANDGVVLVGQKRITGAC"
     misc_feature    complement(19916..19930)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     misc_feature    complement(19925..19940)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     misc_feature    19952..19966
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.65"
                     /tool="antismash"
     misc_feature    complement(19954..19965)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.43"
                     /tool="antismash"
     misc_feature    19959..19973
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.76"
                     /tool="antismash"
     misc_feature    complement(20479..20488)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.59"
                     /tool="antismash"
     gene            20675..21472
                     /locus_tag="CG736_RS21895"
                     /old_locus_tag="CG736_21825"
     CDS             20675..21472
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059614.1"
                     /locus_tag="CG736_RS21895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_21825"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_100587879.1"
                     /transl_table=11
                     /translation="MTRVRAITVALTAAALSVTTLVAATQASAAGVNYVALGDSYSAGV
                     GSGSYTSESGSCSRSTNAYPYLWKNAHAPTSFKFVACSGATTNDVVANQLSSLSSTTTL
                     ISITIGGNDAGFASTMQTCVLSSDSSCLSAVNTAKSYANNTLPGKLSSLYSQIKAKAPN
                     AHVVVLGYPHLYQVPGSCLVGISDTKRTAINSAADTLDTVISKQVAAAGFTFKDVRSIF
                     SGHEICGSSSQWLNSTTLPISDSYHPNSSGQAYGYLPSFSAGV"
     misc_feature    complement(21577..21593)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.04"
                     /tool="antismash"
ORIGIN
        1 cctcgctgac cagcgaattc gccgaccagt cggacgagtt ggcggccctg gaggtgcgct
       61 ccagcatggc cggccggtgg cggatgtcca ccataggaat cgtgatggcc gcgatgcccg
      121 cgatgatcta ctgggcggcg ggcctggcca ccgcgacggg tgcgccgatc gtctcgctgg
      181 gcaccctggt cgcgttcgtg tcgctgcagc agggcctgtt ccggcccacc gtcagcctgc
      241 tgtccaccgg cgtcgacgtg cagacctcgc tcgccctgtt ccagcggatc ttcgagtacc
      301 tcgacctgcc ggtggagatc gacgagcccg agcaccccgt ccacctggag cggatccgcg
      361 gcgacgtgcg cctcgaggac gtcgagttcc actaccgggc cgaccaggac cgcccgacgc
      421 tgtccgcgat cgacctgacc gtccccgccg gaggctcgct cgcggtggtc ggcgagaccg
      481 gctccgggaa gtccacgctg tcctacctgg tgccgcggct gtacgacgtc accggcgggc
      541 gggtgctgat cgacggggtg gacgtgcggg agctgtcctt cgagacgctg gcccgggcgg
      601 tgggcgtggt ctcccaggag acctacctgt tccacgcgtc ggtcgccgac aacctgcgct
      661 tcgccaagcc cgacgccacc gacgaggaac tcgtcgccgc cgccaaggcc gcccagatcc
      721 acgagatgat cgccgaactg ccggacggct acgacacctt ggtgggggag cgcggctacc
      781 gcttctccgg cggcgagaag cagcgcctgg cgatcgcccg gacggtgctg cgcaacccgc
      841 cggtgctgat cctggacgag gccaccagcg cgctggacaa ccagaccgaa ctggccgtcc
      901 aacaggccct ggacaccctc gccgagggcc gcaccaccat caccatcgcg caccggctgt
      961 ccaccgtccg ggacgccgac cagatcgccg tcctcgacca cggcgccatc gccgaactcg
     1021 gcacccacga gcagctgctg gcccgcgacg gccgctacgc cgcgctgctc aaccgggagg
     1081 cgctgccggt ggccgtcggc tgaccgggac gacgccgggt caggcggcct tcggggactc
     1141 gttgtactgc tcggcgagtt cctgaccgga cagcgcgtgg atggcggcca tcacctcgtc
     1201 ggtgacctgc cggcgggcct tcgcggagcg ggcctggccg tgcaggtcgt cgaagcgcag
     1261 cggctcgccg aaccggacgg tgatccggct gatgcgcgga atgcgcttcc cgaccgggag
     1321 gatgtgctgc gagccctcca gggccaccgg gacgaccggc acgccggcgg tcagcgccag
     1381 ccaggcgacg ccggtcttgc cgcggtacag gcggccgtcc agcgaacggg tgccctccgg
     1441 gtagatgccg aacgcccggc cggagtcgag gatctccagc ccctcctcca gcgaggcggt
     1501 ggcggcccgg acgctgccgc gctccaccgg gacggcgttg atcacgtggg tgaagaagta
     1561 ccgggagatc gcgcccttga gcccggtgcc ggtgaagtac tcggccttcg ccaggaagaa
     1621 cacctgacgc ggcgcggcca gcgggatcac cacgctgtcc acgaacgaca ggtgattgct
     1681 cgccagaatc accccgccct tgcgcggcac gttctccagg ccctcgatgg tcggccggta
     1741 gacggcccgc gcgagcggct tgagcacgag cttggtgacg aggtcgatca actggccctc
     1801 cctggccgaa ggtcggaccg cccggggccc aagggcggta cccgccgagg ggcgaggcac
     1861 gcggctcgga cggaggtcgg accactgggt tcgaatcgca gactacgaca tcgccccggc
     1921 cgcccgtcca ccgcccgtgg ccatcccggc actgcgatcc tcgtcacgcc cacctggtgg
     1981 gaaagccgct tcccaccagg tgagacgggg tcgggagaac gatcggtcag cggcggaccg
     2041 ggaagatccg gctgaccacc cgctcggcgg cccggccgtc gtcccacggg cagaaccgct
     2101 cccggaaccg ctgccgggcg gccggctccg ggtcgcccgc gagcagcgcc tcgaccagcg
     2161 cgtcctgctc ggtggcgacc gcgcccggcg gctccttcat caggtcgaag tagacgcccc
     2221 ggacctgctg gtactcctcc cagtcggggg cgtacacggc tatcggccgg tccagcaccg
     2281 cgtagtcgaa catcatcgac gagtagtcgg tgaccagggt gtccgccgcc aggtacaggt
     2341 cctccaccga cgggtggtcg gagacgtcca gcagccgggc cgagccgggg cgggccgcca
     2401 ggtcgcccgc gccgccgtcg tggaagtagt gggtgcgcac catcaccgtc cagccggagc
     2461 ccagccgctc ggccagcgcc ggcaggtcca gcagcggcag gtagccgccc cgggactccc
     2521 ggtgggtcgg cgcgtacagc acggtgcgct gccccggggc gatgcccagc tcgcggcgga
     2581 ccgtcgcgca ctcctccgtg gtggcgtgca ccaggcggtc gttgcgcggg tagccggtgt
     2641 ccagggtctg gtaggtgccg gggaacgccc gggcgaagtg ctcgctggtg tgcgggttcg
     2701 gcgacaccag gtagtcccag cgcgccacgg cctcgcgcag ccgctcgaag tccatcccgt
     2761 ccgccgcgac cgggtgctcc cgcaggtcca tccccatcgc cttcagcggc gtgccgtgct
     2821 gggtctgcac gtgcaccgtg ccggtccgct tcgccatcgt gtgcgggaag ttgacgttgt
     2881 tgacgaagta cttggcggtg gccatcgcct tcaggtacgc cggggtgttg acgatcacgt
     2941 acggcacccc ctcgggcagc gtcgcggccc gtgccgcgtt ctccaccacc cacacgccgc
     3001 gcacctgcgg ggccagctcg cgggccttct cgtagatcgc cgccgggttg caggcgtacc
     3061 cgcggtgcca gtacgccgcg tacaccgcca ggtgctcgtc caccggaagc cgccggaacg
     3121 cgttgtacgc ggtgaaccgg gcgctgctgc gcatcgcctt cttcacgccc ggcgcgaccg
     3181 ccttggtgcc gcgcttgacg gcgcccggca gccggccgcc gcggcgcagc tcggcgtagg
     3241 cgcgccggga gccgcgggcg gccagccggt actggatgcc gcgcacgccg gacgggaagc
     3301 ggtagccggc cgggcggtgc ctggcgaagt ggccggtgat ccgggcgaag aactcggcgc
     3361 gcagctcgac ggggacgagc cccggggtgt cgtagacggt cagggcctgc ttgacggtgc
     3421 ggtcgaagac cagggtgcgc agccggttcg cccgctcgtc gcggtccagg aacgcgaaga
     3481 tcgcgtcgta ctgggcgaag gcgtctgcgt gcttggccga ggcggtggcg gtgatcgcgc
     3541 ccgggcggcc gcgccggtag cggtagcagg ggcggtccag gtagaccagc cggtcggcgg
     3601 ccagcagcag cgggtaggtg accgagatgt cctcgtagta cccgcggccg aagtgcacgt
     3661 ccaggtcgag caggtactgc cggcgcatga tcttgttcca caccgcgagc accgagttga
     3721 acagcgcggg gtgctcggcg gcggtgcagc cggagaccag cggggagccg gccagcacgt
     3781 gccgccaggg gttcggctcc tcgccgccgt cgtggtagac gtgcgtgaag tcggtgagca
     3841 gcacgtcggc gggcaggtcg cgggtggtct cggcgcgcag ttcggcgagg accgcgtcga
     3901 tggtgccgtc gggcagccag tcgtcgctgt cgacgaacca gacgtaggtg ccggtggcct
     3961 cggcgaggcc ggcggtgcgg gcgccgccca ggccctggtt ctccgccagg tgcaggacgc
     4021 gcatccgggg atcggtggcg gcgtgggcgt ccagcagggc gccgctgcgg tcgggggagc
     4081 ggtcgtccac cgcgatcagt tcgacctcgc cgggcgcggc gccgtcggac cggagcgatt
     4141 ccaggcactg cggcaggaag cgttccacgc cgtggacggg caggacgatg ctgagcaggg
     4201 gtggcacgtg cgttcactcc gcgaagggaa gggggctccg gcagatcgcc cggtccccgc
     4261 ccactctacc gagcgcgtac gggcccgccc cgggcgcggc cgggccgcgg caccccgggc
     4321 gcaggtggtc ggggtgtccg gggcgccgcg ggcggtgcct gtcggcagga agacgaccgc
     4381 cggtgccgcg ccgtaccagc ggcggcaccg gcagtccggt tggcggcccg accgaccctc
     4441 aacggtcgac cgccggtccg tgcaccacgc aggagtcgga ccgccgcagc gtcgagacgg
     4501 ccgcaagtga ctctctgtgg tgccggaagc ctgtcatcgg atgagcaggt gattcgttca
     4561 tgttcgaact catccgaccg gggatcggcg ggcgcgaccc gtgatccctt gtcggtacag
     4621 atactgcttg gaggttccgg cggcgtcaat ccctcgtatg tgttcaattt ctgaactctc
     4681 gatgccgcgc ccgacagctc ggcgccgggc gcgggcggtc cggcggcgga gcggctcgcg
     4741 cgcggtcgaa accggtgcgg gacggacgga cgtccgtgcg cccggcgcac cccgctgccc
     4801 cggtgcgccc gcgaacgccc cgagccgctg cggcacctga cgcccggtca tgcttggatg
     4861 gtgcaccatc aaccgatgcg cagtcgtgac cgggaccacc gtacttgggt gacacggcag
     4921 tccgttcgca cgatacggtg gcagaacacc aggacggttg catgaagacc gtcatagccg
     4981 gatagtcttc gcctcacggc cctggcgcct cgtaggggtg ggaaacagat ggaacagatg
     5041 caagtgcgga cgcggccccg ggtgcccgcg atccagtgcg gcgtcggcgc gaccggccgc
     5101 cggatcgacc ggcacctcgc ggtgctcggc gcccccgcgc tctcgacggt ggacacggcg
     5161 gaagcgctcg gcctgataag ggaactgacg ccgcgtggac ccagcgtccc ggtcgccgtg
     5221 ccccggcgct ccgtgcgggt ctcgctgatg gccccgctgc gcaggctcaa gcggagcatg
     5281 ttcggcagcc gcggctgagc gcaccgacgt gaggacgggc ggccaccgct cgtctccacg
     5341 aacccgacgg accgggagtc cgtcgggctt tcggcgtccc ctccggtagg cgggggagcc
     5401 gtggcgcggg gttgcgaggc gctggcgtgc cctggcgggc ggccttgcgg tcgggtggcg
     5461 ttcggcggcc gccccttcgg acggggtcac aagatcggcc aggatggccc catgtccgac
     5521 accttccaca ccaccacgct cgacgtcacc acgggccgca gagaagtcgc cctcgacatc
     5581 accgaccgct gccacgactt cctccgggac gtcaccggcg gacgcgacgg cctgctgaac
     5641 gtcttcgtcc cgcacgccac cgccggcatc gccgtcatcg agaccggctc cggcagcgac
     5701 gacgacctgc tcagcacgct gcgggagctg ctgcccgccg acgaccgctg gcgccaccgg
     5761 cacggcagcc cgggccacgg ccgcgaccac gtgctgcccg gactggtcgc cccgcacgcc
     5821 accctgccgg tggtgggcgg ccgactcgcc ctcggcatct ggcagtcggt cgtcctgatc
     5881 gacaccaacg gcgacaaccc ggaccgcacc ctgcggctct cgttcctcgg ctgaccggcc
     5941 ggccgggcgg gacggcgcac ccgccggcgg gccggtcggt cgtcagaacg tgatcgacac
     6001 cccttggacg cggtggttgt cgtcgagccc gccggtggcg cccgtgaagc cgaccaggac
     6061 ggcggccgga acggccacgg tggcgtcgat cgccgccttg ccgtccacgg tgacctggac
     6121 gcggccgccg gtgacctgca cgtccacggc gtgggtgccg gtgcgcaggt cgccgatgtc
     6181 ggtcgcggtg gcggcgtagg tgagcgcgtc gccgttgccg ccggtggcca ggccgacgaa
     6241 gttggcggag gggtcgttgg cgttctggga cgtgtccagg gtgacggcga ggccgtgcag
     6301 gccggagtag ccgagcccgc cgccgccccc gccgagcgag tgcggcgtct cgtgggccgc
     6361 gtccagcagg acgaaggcca ggccgtccgc gcccgagccg ccgccgatga cggccgtgaa
     6421 gtgggcgcgc aggttcgccg agggcacggt catgtcgttc agcgcggatc cggtctggcc
     6481 gttgatcgcc tcggtgagca cgatgtcggt gttggagagc acggccgtgc cgttgaacgt
     6541 ccaactgccg gtgctcggct gggagaggct gccggaggtg actccggtgc cggtgaaggg
     6601 gacgggctgc ttgccctggc cgtcgtcgcc ggtgatcacg aactggccgg aggccgctcc
     6661 ggccgcggtg ggggagaaga ccaccgcctg gtggaccacc tgcccggggc cgagcttctg
     6721 gccctcggcg atcgggtcgg gggcggcgaa gggcgcggtg ggcggagcgg ccttggtgat
     6781 ggtcagcacc aggttgccgg tgttcgtgat gtcgaaggtc ctgccgagcg atccgccgac
     6841 cgcgacctgg ccgaagtcga gcgaggccgg actgatcgtc aggtgcgggg cgccgacgac
     6901 ggccgtaccg gtgagcggga ccgtgaccga gtggccgtcc gcgccggtga cgacgaactg
     6961 cgagctgtcg ccgccggccg ggctcgcgac ggtcggcgcg taggtgacgg acacggcgat
     7021 cgaggcgccc ggggcgaggg tggcgccggc cgcgggcagg ccggtgaccg tgaacggggg
     7081 cgacgacggc gtggcgccgg cgatcgtctc ggtggcggtg ccggtgttgg tgacggacac
     7141 gccgagcgtc atcgaggact gggtgggcag ctggccgaag tccaacgacg gcggtgacgc
     7201 ggcgaatccg ggctgggtgc cggtgccgtt caggtcgatg ccgacggtgt cggcgacgcc
     7261 gttcgtcgtc acggcgaacg acagcgtcgc cgtcgctccg ccgggcccgg tcggcgcgaa
     7321 gcccaccggg acggccaggg tgcctccggt gttcagggtg acggggaggg tcgggggcgt
     7381 gacgctgaac ggcgcggtgg tggtgatcgc ggtgaccgtc acgctgcgcg tcgcggtgac
     7441 cgtcgccgtg gcgttcccgg tggcgcccac cgcgacctgc ccgaggtcga ccggactgcc
     7501 cgtcagcgcg gcctgggacg ggctgccgaa ggcgaccagg tggccgccgc gggtgccgac
     7561 gtagacccgg ccctcgccga cggcgacctt ggagaacttc acggccgtcc ccatcggcgc
     7621 cgaccagcgc agcttcagca cgccgttgac cggcaccgcg tcgtacgcgc gcagttgggc
     7681 gttgacgccg tcggaaccgt tggggtcggg gcagacgatc cagaccagcg cagagccgga
     7741 ggtcgtgccg tcggacgtca cgaccggcga gcccgggtag tggccgatcg cggcgctgct
     7801 ggagcccgca ttggtcagga cgggcgtgcc ggcgccgtcg acgccgaacc tcagtgcgcg
     7861 gaggtggccg tcgttctcgg ggacgtacac gaagccgccg tcgccgcccc agaccgccgg
     7921 gtggccccag atgccgcgga acggcccgcc gatggacagc gcctggtccg agccgccggg
     7981 cccctggctg cgaccgccca ggtcgtcccg gtcgaggagg aagacccggc cgtcctttcc
     8041 gatctggacc agcagcttcg ggtgggccgc ggtgccgaac ggcggcgagg gcagggccac
     8101 cgggccgccg gatccgaggt cctggtcgtt cagatccaga ttgtccgcgt tgccggggct
     8161 gaagaagtcc accgcggtga gctgcccgcc gctggacagg tggaccaccg actcggccag
     8221 gtgaccgggc ggctgcttgc ccgggccggg cgcgggcgag acgccgttgc cggtggagaa
     8281 gaagatccgg ccgggaccgt ccgagaccag gccgccgccg cccatccaga ccccggcctc
     8341 cgtgtcgctg gccgcgttct ccgtggacca catgcgcagc gcacgcgtcg ccgtgttcac
     8401 cccgaccacg tagccgacgt acggtttgac gtcgcagtgc gaggcgaacc cggcgaacac
     8461 ctcgccgtcg agcagcagca ggccgggccg ctgctgcgcg gtgaacgggt tgaacgtgtt
     8521 gcccgggttg ttcaccgggg agccctggat cgtcaccggc cagcccgcgg cttcatggcc
     8581 ggtcgccacg tccaggctgt gcaggaacca gtgcgggtgc ttggtgtccg ggccgtcgtt
     8641 gaccttggcg gtgaggtaga cccgccccga cgaggggtcg aacaccgggg tggaggtcac
     8701 gccgatgttg gggatgaggt cgccgcagcc gatcgcggcg gccggccagg ccgggccgag
     8761 cgacttggac cagaggaccg caccggtgac ggcgtggatg ccgtagacgt tgttgttctc
     8821 ggtcgcgacc accacggtgg acccgatgac cagcggctgg gcgtagacct gcccgtccac
     8881 gggcgtcgag aacaactggc cgaagtcgcc ggcgctcacc ttgctgggcg ccagctgcgg
     8941 ctggtgcggg tcccagccgg tgcgcatcgg attcatcgag acggtcgggt cgtgggcgac
     9001 cacattctgc gtcatcgtgc gctgcctctt ccgtttcgag cgactgtcgg ggggatgtga
     9061 cggtgggtca tgggggtgtt cacgcactgc tcacagctgc agctccatgc cgtcgccggc
     9121 gacctccacg ccctcggccg cgagttcctc gtgccggtcc gagtccgggt cggtcagcgg
     9181 gttggtgttg ttgaggtgcg tgtagagacg ccgggtgcca gggtgcgagc gcagtcggcg
     9241 cagggtgccg tccggcccgg cgatcggcag gtggccgaag gcgcgggcgg tgcggcgctc
     9301 gccgctcacg tggcgcagct cctcgtcgct ccagaacgtg ccgtccagga gcaggcagtc
     9361 ggcgccgtcc aggaacgcgt cgaatccgtc cggccagtcg gcgagcgagg gtgcgtagac
     9421 cgcacgggct ccggtccgag tgtcggtgaa gcggtaggcg acggtccagg ggccgggagc
     9481 gtcgaagtgg gcggcgtagc gggggcgctt gtcgctcacc gggaaggcgt cgaccgtcag
     9541 accgccgtcg agccggagcg gccggtcgag cgggtgccag cgggaggcgc cgtagcaggc
     9601 cagcaggccg cgcagcggga ggacctcccc gaggctgcgc cagaccggcg gcggggcgtg
     9661 gacgtccagt tcggcgccct cgcgcagggc cagcaggccg gtggtgtggt cgagttcgcc
     9721 gtcggtcagc aggaccccgc gcagcggtgt gcggcgggtg ccgtccggcg gggtcaggcc
     9781 gggcgcggcg agcaactgga cgcggaggtc gggcgaggcg ttcaccaggt accaggcgtc
     9841 gtccgagacg ccgacggcga ggcactcctg ggtccgccag gcgcccgggc cggccgtgcg
     9901 ggccctggcg caggtcgggc aggcgcagtt ccactgcggc aggccgccgc cggcggcggt
     9961 gccgagtacc cgtagccgca tggcttccct ctctctcggc tcaggccccg cgaggcacca
    10021 gcggcacggt cggcgccgac tcgccgtccc ggaccagccg ggtgaccagc gcgtggtgcg
    10081 gcgagagccg gcagaccggg tcggtggcgg ccgggtcgcc ggtgagctgg aaggcctggc
    10141 agcggcaacc gccgtggtcg agctccttgc gctcgcagct gcggcagggc tcgggcatcc
    10201 agtccgtgcc gcggaagcgg gtgaacgcgg gggagtcgaa ccagatgtcc gccagcgggc
    10261 ggtcgcgcac gcccgtcacg ccgagccccg ggatctgcgc ggcggcgggg cagggcagca
    10321 cgtcaccgtt cggcgcgacg gtcagctggc ggctggccca gccgttcatg cagggcttgg
    10381 gccaggtctc gtggtggtcc gagacgacgt agacgatctg caggacgccc gccaggcgct
    10441 cgcgggcggc cgtcaccgcg gcctcggccg ccgccagttg ggcacgggtc ggcagcagcg
    10501 cggcgcggtt gcgcagcgcc cagccgtagt actgggtgtt cgccagttcg aggcggtccg
    10561 cgccgagctc cgccgccagg tcgatcaggg cggggacgcg ttcgatgttg cgccggtgca
    10621 gcacgacgtt gaccgtcagg gccaggccgg cggccctgac caggcgggcg gcggcgagct
    10681 tgcgggcgtg cacgggccgg ccggccagcg cgtccgccgg ggcggccgtc gcgtcctgga
    10741 agctgagctg gacgtggtcg aggcccgcgg cggccagtcc ggccagccgg gccggggaga
    10801 gcgactgccc gccggtgatc aggttggtgt acaggcccaa cccgcgggcg tgcgccacca
    10861 gcgcgggcag gtcgcgccgc agcagcggct cgccgccgga caggtgcacc tggagcacgc
    10921 ccagggcccg ggcctcggtg agcacccgcc gccactcggc cgggctcaac tcgtcggcgt
    10981 attcgtccag cgcgaccggg ttggagcagt acgcgcagcg cagcgggcag cggtaggtca
    11041 gttcggcgag caggccgaac ggccggtccg gccgggcgcc gtcctgagcc tcgggggtcc
    11101 cggggctctc gggggtctcg cgaacggccg gtgtcccggg aacggtcggc ggccggggcg
    11161 ggtcggtcgg tccggcctcc agcaggcact gctcggccag cgaggcgagg aaggaccgca
    11221 cctcggccgg tcgcaccccg gtgtactgcc gctccagttc ggcgaggatc gccgtggtgc
    11281 cggtggcgcc gtcgcagcgc gcgagcacgg cggcggccgt cccgccgagc accagcacgc
    11341 cctccggatg cagcagcacc gggacggacc gcacctggtc gtggccgagc cggacgcctc
    11401 ggcgcaggcg ccaggggccc tcctcgtccg cggtcactcg tcagcccgcc gcggccgcgt
    11461 gctcgatggc gtcgagcatc gaccagagga cgtcgcactt gaaggcgagc gcggccaggg
    11521 ccgcgtcctg ctgctcacgg ctggtgcagt actcggtgac caggcccagc gcgtgggccg
    11581 agtcggcgtc ggccacggcc ggacgctgct cgaagtaccg caggccggcg ggctccaccc
    11641 agccgtagtg ggtgcgcagg gcggtgagcc ggtcgcgcat caggcccggc gagaacagct
    11701 cggtgagcga ggcggcgacg gcctcgatcc acggccgggt gcgggcgaag ttcacgtagg
    11761 cgtccgtggc gaagcgcacg ccgggcagga cgtggcgctc gtccagcacc tccgcccgac
    11821 cgagcccggc ggcctcggcg agggcgagcc agtcgacgtt cccgccccgg tcgggcgcgg
    11881 tgccgtcctg gtccgcgagg cgcttgaccc agcggcggcg gacctccggg acggggcagt
    11941 tggcgatcac cgccgcgtcc ttctggggca gccacttctg atagtaccag cgattggcga
    12001 tccaggaccg caactccggc tcgctcaggc cgccctggtg cagtcgcagg tggaaggggt
    12061 gattgtccca gtagctctcg gagtgcgcct gcagggcggc ggtgaactcc gggacggtac
    12121 gcgctgtccg gtccgtcatc gccggccgct accgtcggcc cgcataggcc gtgacctcgt
    12181 gcgcgagctc gatgctctgt gcgtccggcg gcgaccaggc ccgccggacg tccgggcggg
    12241 gcggcggccc ggacggcgcc gggcggggcg ggtcggcggg gccggcgggc aggtggggcg
    12301 agggggcggc ggtgttcggt cggttcgtca tacagcaccc cgggggtggt cacgatggga
    12361 tgtacacggt cggtttccac catcgatcgg tgccctgtgc cgcgcaatcc ggcgagggtg
    12421 cggccggggc ccggacggcg ggggacgtac tctggacgca tggcggagca gcagtcggag
    12481 accaggggcg ccgaacagat ctgcgaggtg tcggccgacc cggagcaggc ccggcgcggg
    12541 ctgcggccgg gcgggcccgg cgagcgcgcc gcgtgtgtgc tgtgcggcgg ggagaccgag
    12601 tacccggccg agacgcccgg atccacgctc tgcccggtct gcacctggca gcaggcccag
    12661 cgtggcgcgt gctccggctg atgatccatc agacaatcgg gcaatgaccg tttttgtgcc
    12721 gagcgccggg cccgccgccg gccggctgga acgccccgac gccacgctcg ccttcgagac
    12781 caccggcagc gccggcccgc tcgccgtgca cgcgcacggc tcgctgtcca gccgggccca
    12841 cgagcagcgg gccggcctgt tcgactggac gccgctcacc gcgacccacc gcctggcccg
    12901 ctacgacgcg cgcggccacg gccggtccac gggccggccg gtcgccgccg actacagcta
    12961 ccccgcgctc gccgccgacc tgctcgcgct ctgcgaccac ctctcgccgg acgcccccgt
    13021 caccggactc ggcgcgtcca tgggcactgc gacggtgctg tgggcggcgc tcgcccggcc
    13081 cgaacggttc gaccgcctgg tgctggccgt ccccgccgtc gcctgggcgg cccgcgagcc
    13141 gcgccgggcc gggctgcggg ccgccgcgac gctggtggag cggcgcggga cgggcaccct
    13201 cagggccgcc gcgaagttct ccggaccgcc cgccgtcctc gccgaagccc cccagtacgc
    13261 caccgagttc gacgccgtcg aggacctcgt cccggccgtc ctgcgggccg ccgccgacgc
    13321 cgacctcccc acccccgacc gcctccgcga cctcccgcac cccaccctga tcctggcctg
    13381 gccgaccgac cccgtccacc ccctcgccac cgcccgcacc ctggccgaac acctcccgaa
    13441 cgcccggctg cacaccgcca ccaccctggc ggacgtcagg agttggggac gcctcgccgc
    13501 ggacttcctg gcgggccgcc gacacgggtg aggtccgggg cggcgcgccc gggtggtggt
    13561 tcaggcgtcg tcgcgggtgg tgtggtggac ggtggagccg tggcggtgct tgcggacgag
    13621 gagttgggcg gggatgcggg tgcggaggtc ggcgacgtgg ctgacgatgc cgacggcgcg
    13681 gtcgcgttcg cggagggagt cgagcacgtc catgacttcc tcaagggtgt tctcgtcgag
    13741 ggtgccgaag ccctcgtcga tgaagagggt gtccaggggc atgccgccgg cctcgtcggt
    13801 gaccacgtcg gcgaggccga gggccagggc gagcgaggcg aagaaggact cgccgccgga
    13861 gagggtggcg gtgtcgcgct cgcggccggt ccaggcgtcg acgacgtgga gggagaggcc
    13921 ggagcgcttg gtgccggaga ccaggccgtc gctgtggacc agggtgtacc ggccgccgga
    13981 catcttcagc aggcgctggc tggccgcggc cgcgacctgc tccaggcggg cggccagcac
    14041 gtaggactcc agacgcatcc gcagggcgtt ctcggcgggc gcgcccgcga gcagcgcggc
    14101 caggcggctg atccgggcgt acgcgtcgag gacgggggcg aaggcgtcgg cgagggcggt
    14161 caggtcgcgg gtgatccggg ccagcgccgc cacccggtcg tcggcggtgc ggtgcgcggt
    14221 gtcggcggcg cgcaggacgg cggtggcgtg ttcctccgcg gcgtgcgcga actccggttc
    14281 ggccgaaggg agttcggcgg ccgcgcgcag ctccgggtcg gcgaggcggg cggcggcctg
    14341 ctccagtgcg gcgtccagct gctcgaactg ccgctgaagt gcgtcgcgtc ggtgggcggg
    14401 gagctcggcg gcggcgagcg ccgacaggtc ggcgaagccc gcgtcggcgg cggcgcgctc
    14461 caacgcgccg gtggcctcgg cgcgtcggtg ggtggtctcg gcggtggtgc gggccgcgtc
    14521 gaggacggcc gtgacggcgg ccgcgagggc gtccaccgcg gcggcgcggg ccgcgaccga
    14581 cggggcgtcg ccccgggcgg cggcgatccg cccggccagc gtgtcgagtt cggccgcgac
    14641 ggtgcccagc cggtcggcga ggacggcgcc gcgctcgccc gcctgccgca gccgctcgtg
    14701 gcgggcccgg cgttcctgct ccagccgctc cacctgctgg cccaacggca ccagccgctc
    14761 cgcggtgtgc agtgcctcgc gccgctcggc ggtcaactcg tcgagaatgg cggtgagttc
    14821 ggcgaccgaa cggccggcgg cggcggtctc ggcggccgcg gcgtccacct ggagggtgcc
    14881 caagcggtgc ttggcggcgt cgagttcggc ctccgctgcg tgctgggcgg cgcgggcgcg
    14941 ctgctcgtcg gcggccgtga cctggtcggc cgacgggcgg gcgggggccg ggtgttcggg
    15001 cgagccgcac acccggcagg gctcgccgtc ggccagctgg gccgccaact cggcggccat
    15061 gcccgccagt cggcgctcct ggaggtccag ggtgcgggcc cgggcgtcca gcgcggcgtc
    15121 cgtcagggtg cggacccggg cctcggcggc ggacagtgcg gcccggagcg agcggtggcg
    15181 gcgggccgcc tcctggcggg ccgtcaactc ctggtgccgg gagtcgagtc gggcgagcag
    15241 cgcgtgcgcg tcgcgggccg cgtcgaggtc gacggtcagc tgcttcagct ggtcgtcgaa
    15301 gccggacagc cagtcctgcg actcctccgc caggtcgtcc gcccgcttct gctcggcggc
    15361 caactcgtcg cgctcgacca gcagtcggga gtggcgctgc tcgtccgcgc gggcctccgc
    15421 gaggcgggtc gcctcggtgc gcaaggtgcg ttccgcagcg gtgggttcga ggtcgccgag
    15481 cagctggacg gcccacggcg cggcggcccg ggcggtgagc gtcacgcggt gggccgactc
    15541 ggcggcggtg gcggcggcgt gggcggccag cgcgccctgg tgcagggtgc gcagcgggga
    15601 cagcgccccg gcggccagcg cgaggcgcag gcgggcccgg tcgggggccg actcccggtc
    15661 ggcgccggcg agtcggaggt ggtcctgctg cgcggagcgg tgtcggtgct gacggtccgc
    15721 cagggtgcgc tgggcgtcca gccgcgtgcg ggcccgggtg cgggcggcct cggcgctctc
    15781 cagcgcgagc gccgtcgcgg tgacgcgttc ggcggccgtg ccgcgcagca tcgccgccca
    15841 ggccagcacg tccgccgcgg aggcgttctc gtcgggtcgg tgcgcggcgg cgtccgcggc
    15901 gagcggaccg gcggcctcct cggcccgggc cgccaggtcg cgcagcttct gccgcccggc
    15961 ctgcacctcg tgctcctggc gcagccggcg ctccgccgtc cagcgctcca actggtcgaa
    16021 ccggccggtg tcgaacagct tgccgagcag gtcggcgcgc tgcttggaat ccgcgcgcag
    16081 gaaccgcgcg aagtcgccct gcggcagcag caccacctgg cagaactggt cccggctcat
    16141 gccgagcagc cgggtcagct cctcaccggc ctcctggtgc gacttgctga ccgcgaccca
    16201 gcccggctcg ccctcgccgg cgtccgcagc ccactcgcgc agcagcgtct gcgccttgtc
    16261 cgcggtgaag cccgaaccgc gcttcttagg acggagctgc tcggggctgc gggtgatctc
    16321 cagccgccgc ccgcccagcg tcgcctccag caccacctcg gtgcgccgcc cctggtcggc
    16381 gtggtcgctg cgcacgccgt tgctcctgcg cgagcccggc agttcgccgt acagcgcgta
    16441 gcagaccgcg tccagcacgc tgctcttgcc cgcgccggtc gccccgcgca gcaggaacag
    16501 gccggacgcg gtgagccggt cgaagtcgat ccgctccgtc gacgcgaacg ggccgaacgc
    16561 ggtgacggtg agctggtgca gcctcatcgg gcgctcccct tcgagaggtt catcggccgt
    16621 tctcctcggc ccggtcggcg gccgtgcggc gcaccgcctc caggccctcc aacagccagg
    16681 actgctcggt gtcgtccaac tcccgccccg ggcggacgtg ggcgacgaag ccctccacca
    16741 cctcccggtc gctgcgcccg ctgacccgct gcgcgtacga cccggacgcg gcctgctcgc
    16801 cgccctcggg ttcgaacagc aactgcaggg tgtgcgggaa gcggacccgc agccgctcca
    16861 tcgggtcgac cggccggacc gggtcggtca gcgtggcctg cacccaggcg ccctcggccc
    16921 actcgtgctc gtcggcggtg agcagctcgt ccaggcggcc gcgcagctgg gccagccgac
    16981 gcggctgggg gcagaggatc cgggtggcct cgacggcgcc ctcggcgtcc aggtcgacca
    17041 gccacatcga cttgcggtgg gtggtctccg agaacgagta ggcgagcggc gagcccgagt
    17101 agcgcaggtg cggggcgagg gtctggcagc cgtgcaggtg cccgagggcc acgtagtgca
    17161 ccccgtcgaa caccccggcc ggcaccgact gcacgccgcc caccgcgatg tcccgctcgc
    17221 tgtcgctctg ctcgccgccc gtcacgaacg cgtgcgccag caccacggcc cgggtgcccg
    17281 ccggacgcgc ggcgaggtcg gcccggacgg cgtccatcgc cgccgccagc acctgctcgt
    17341 ggccgccctt cgccaggccc agccggtccc ggaccagcgc cggctccagg tacggcagcc
    17401 cgtacaccgc gaccggcccg tgcccgtcgg ccagcagcac cggctcggcg agcgtgcccg
    17461 gatcggtgcg caggtgtatg cccgcccgct cgatcagccg ggacgcgacc ccgagccgac
    17521 gggccgaatc gtggttgccg ctgatgaaga cggtcgggat gttccgctcg gccagccgcc
    17581 acagcacgtc gtcgaagagc gcgacggcct ccagcccggg cagcgcccgg tcgtacacgt
    17641 cacccgccac cagcacggcg tcgacccgct cggcgacggc ggtggccacc aggtggtcga
    17701 ggaacgcgcg ctgcgcctcg tgcaggttct cgcggtggaa cgaacggccc aggtgccagt
    17761 ccgaggtgtg cagcagcctc acgccgaagc tccccgcagc atgtctgtca ctcctcgtcg
    17821 ctttcatggt ggtccggccg gtaccgagta tcacaggtgc gggtgacagg ccgggtcggg
    17881 agtgacggga ggggtggtcg ggacgggtgg ggcgctgacc cgggtggcgg ccgggactgt
    17941 tcatcggtcg ggtgttcggg gaagatcatc aggtggcgag ggcggccgcc cggagtgcgg
    18001 agggagtggc atgggcatcg aatacagccc ggagatctcc gaactgctcg ggcgggtccg
    18061 acgccggccg aacgccggct ggccctggca cgccgggtcg gcggtgccgg aggggctccc
    18121 ggtgaagcag tcctggggct ggctgttcgc ccccgacggc cgggtgctca cgctggtcaa
    18181 cccccgggac ggcgtggtca gcctccccgg cggctcgctg gaggcggagg acgcgggcga
    18241 tccgggcgcg acgctggccc gcgagtcggc cgaggaggcc caggcgctga tcgggccgcc
    18301 ggtctacctc ggctacctgt acgaccgggt cggctcggcg aacggcggcc acgagtgcgc
    18361 ccgggtgcgg atggccgcgg cgctgcacgg cgtggcccgg tccgcccccg atccggcttc
    18421 cggccgccac taccgtcgtc tgctggtcgc cccgggcctg gccgtcgaac tcctcggctg
    18481 gggtgcggcc ggactgcagc aggcccgggc ggcggtggcg gcggcggtcg gggtgctggg
    18541 ggttccggcg tcggcgaacg agacgatcga ggaactgccg ctcgggggct gctggctgcg
    18601 ctgagcccgc cgcccgggtg cgcaatcggt gcggtgagtc aactggtttt gctgccaacc
    18661 gagttggcgg atccggcggg tagcatccgc ggcatgacgg atattcagga gttcgatgcg
    18721 cgtgccctga aggtcacgca gacggtcgtc gaccgcgtcg ccgcggaccg gctcgaccgc
    18781 ccgacgccgt gcggggactg gacactcggg cagttgctcg cgcacatgac gggacagaac
    18841 cacggcttcg cgttcgcggc cggcggcgag ctgcacgggc gcgaggtgtg gcgcgaccgc
    18901 ccggtcggcg acgatccggg cgaggagttc gccgcctcgg cggccgcggt ggtcgcggcg
    18961 ttcggcgagg agggcgtgcc ggagcgggag ttctggcttc cggaggtgcg cggcgggcag
    19021 tggttcccgg ccgttcaggc ggtcggcttc cacctggtcg actacgtggt gcacggctgg
    19081 gacgtcgccg cctcgatcgg cgtcgggatc gagttcgacg cggacgtgct ggcggccgcg
    19141 ctgacggtcg ccgaagcggt tccgaccggt gcttcccgcg agcgggaggg cgccgcgttc
    19201 gcgcccgcgc tggacgtacc ggccggggcc tccgtgctgg accggatcct gctgctgctc
    19261 ggccgcgacc cgaactggtc cgcgccgggg cacaccggct gacgggggtt cggggcgcgg
    19321 gcgggccggt gtcgccccca cgggggtggg gcggcaccgg cccggcggtc ggggcgcggg
    19381 gcggtgcggg tcagcaggcg ccggtgatcc gcttctggcc caccaggacg acgccgtcgt
    19441 tggcgatgac gacgctgatg gccgcggtgc ccgcggagtt cgacgaccac agcgcggtgc
    19501 cgtactgggt gtacagcacg aagttgccgt ccgactggta cgaggcgtgg tgggcggcgc
    19561 tcccgttggt gccggtcgcc cagcacaccg tgcggccgct gccggacccg cggtactcga
    19621 cgaggttgcc gtccgactgc aggatcagct ggtagacgcc gctggggctg acgatcgagt
    19681 ccccgacgtt gaggctctgg cccgggatga tgccctggct ggaggtcgcc gacgcgctcc
    19741 cggtcgcgcc gaggacggcc gccgcggccg cggtgacggc gacagcggcc ttggccgcac
    19801 cgcgaatggt cttgttcatc attgccccct tgctcaatat gtgtccgata tgtccgccgc
    19861 attcatcggc ggcgaacgcg gatcaaagct agccgcaggg gcgggcggaa agatggtcga
    19921 cagtcgtgat tcacctcaca ttgtcgaggg tttaatatcc ttttccgaaa tttaccgccg
    19981 cactgcggga aatttgcgaa accctgccgg aggggggcgg ccgggtggtg cgagtcacgg
    20041 ctgcgggggg tttaactgca cgctgtgatg gccgagttga ccttgcgttc gatcggcggg
    20101 cgggtgtcgg ggccgggtgg gggtgcgagc cgcgcgggtc gggaattcca cctccgcccg
    20161 ccgctgggca gcggcgctgc tcgttggccg ggcgagtgtc cgcggcgaag tggcgggcgt
    20221 ggtgcggaat tcttcgggcg catcggaaat cggcgaccgc cgaccgatat tttgtcctcg
    20281 atgtccggag ggtgggacgg ttcggcgcgc ccgatccggc gctcggtgcg cgctcggacg
    20341 gcggcggtgc gagcggctcg cgccgggggg tgccgcgact gcccatttgg ggcgggtggg
    20401 gctggagtgc gccgtgagca cgctgtgtca cgcccccatt gcgctcggag atggggcctg
    20461 aggtgacggt gcgtcaggtg aaaaatcggg cgatcggacg ttcggacggt gcttcgcggg
    20521 atttccgcag cccaggtcag gggtgggtct ccgcgcgtag cgaaaatcga gtgaccgttg
    20581 gatgagagtt cgtcaaattc tttggcatga ccgcttccct gcgaggctac tggctggtat
    20641 ccaatgtgtg gcctgcgtca cccatggagg aaacatgact agagtccgtg ccatcaccgt
    20701 cgctctcacc gcggcggccc tgtccgtcac cacccttgtc gccgccaccc aggcgagcgc
    20761 cgccggcgtc aactacgttg cgctcggcga ctcgtactcg gccggcgtcg gctcgggcag
    20821 ctacaccagc gagagcggca gctgcagccg cagcaccaac gcctacccgt acctgtggaa
    20881 gaacgcgcac gccccgacct cgttcaagtt cgtggcctgc tcgggtgcga cgaccaacga
    20941 cgtggtcgcc aaccagctca gctcgctgag ctcgacgacc acgctgatct cgatcaccat
    21001 cggcggcaac gacgcgggct tcgcgtcgac catgcagacc tgtgtgctga gcagcgacag
    21061 ctcgtgcctg agcgccgtga acacggcgaa gagctacgcc aacaacacgc tgccgggcaa
    21121 gctctccagc ctgtactcgc agatcaaggc caaggcgccc aacgcgcacg tggtggtgct
    21181 gggttacccg cacctgtacc aggtgccggg cagctgcctg gtcggcatct cggacaccaa
    21241 gcggaccgcg atcaacagcg cggcggacac cctggacacg gtgatctcca agcaggtggc
    21301 ggcggccggc ttcaccttca aggacgtccg gtcgatcttc tccggccacg agatctgcgg
    21361 ctcgtcgtcc cagtggctga acagcaccac gctgccgatc agcgacagct accacccgaa
    21421 ctcctcgggc caggcgtacg gctacctgcc gtcgttctcc gcgggcgtct gaccccggag
    21481 ttcaccgaga cgtccgtgac gggcggacga gccggtgtcc gggcccatgg gaggggcccg
    21541 gacaccggtg ttcgtgagcc gccacggact gacgatacgt cagcttattt cagcggcgcg
    21601 gcggcggtca ccgcaggtag tcggtgagcg ccgcaggcgt cagaccggcc gcgcgggccg
    21661 cgtccagggc gcgctgcagg tcgctcgcca gggtgtcggt gaagtgcagg atgatcacgt
    21721 cgccgggctg gagcggaccg ccgtggtaga cgttcgcggc gccggaggtg aagtcggcgg
    21781 tcgcggtcag caggtacctg atgccgcagt tcgcggcggc ctgctgggtg gtggcgtcga
    21841 aggtgaagta cggcggccgc aggatcgtcg gggtggtgcc gtagcgggcg gccaccgcgt
    21901 cgcgggcgtc gcagatctcg gcctgctgct cggcgggcga gagggtcgtc aggtcgcggt
    21961 gcgagacggt gtggtcctgg atggaggagc cgggcgccgc ggtgaccttg ctgaagtagt
    22021 ccggctcgaa gccctccggc atgggcagcg ggaacgcggt gaccggcagc ctgcggtcgg
    22081 cgatcagctg cgcggcctcg ggggtgcgga accagccgtc gtcgatggtg aagaagacc
//
