LOCUS       NZ_NNBO01000005        22820 bp    DNA     linear   CON 14-AUG-2024
DEFINITION  Kitasatospora sp. CB02891 scaffold5, whole genome shotgun sequence.
ACCESSION   NZ_NNBO01000005
VERSION     NZ_NNBO01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kitasatospora sp. CB02891
  ORGANISM  Kitasatospora sp. CB02891
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Kitasatospora.
REFERENCE   1  (bases 1 to 511112)
  AUTHORS   Pan,G., Xu,Z., Guo,Z., Ma,M., Yang,D., Zhou,H., Gansemans,Y.,
            Zhu,X., Zhao,L.-X., Jiang,Y., Cheng,J., van Nieuwerburgh,F.,
            Suh,J.W., Duan,Y. and Shen,B.
  TITLE     Discovery of the Leinamycin Family of Natural Products by Mining
            Actinobacterial Genomes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 114 (2017) In press
REFERENCE   2  (bases 1 to 511112)
  AUTHORS   Pan,G., Xu,Z. and Shen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUL-2017) Chemistry, The Scripps Research Institute,
            130 Scripps Way, Jupiter, FL 33458, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 04-APR-2016
            Assembly Method                   :: CLC NGS Cell v. 7.5.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002803145.1-RS_2024_08_14
            Annotation Date                   :: 08/14/2024 03:20:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,223
            CDSs (total)                      :: 7,128
            Genes (coding)                    :: 7,004
            CDSs (with protein)               :: 7,004
            Genes (RNA)                       :: 95
            rRNAs                             :: 8, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 124
            CDSs (without protein)            :: 124
            Pseudo Genes (ambiguous residues) :: 0 of 124
            Pseudo Genes (frameshifted)       :: 32 of 124
            Pseudo Genes (incomplete)         :: 102 of 124
            Pseudo Genes (internal stop)      :: 10 of 124
            Pseudo Genes (multiple problems)  :: 18 of 124
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:31:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 459865
            Orig. end                         :: 482685
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NNBO01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22820
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22820
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22820
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12820](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12820)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(100..>828)
                     /locus_tag="CG736_RS37730"
                     /pseudo=""
     CDS             complement(100..>828)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980615.1"
                     /locus_tag="CG736_RS37730"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="putative Ig domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="GAAVSVTNPGNQSTVVNGSVSLQIQASGGTAPLSYSATGLPAGLS
                     INASTGLISGTPTTSGGSSVTVTVKDAAGKTASTTFSWTVTTNQGTCTPAQLLGNAGFE
                     TGTAAPWTTSTGVVDNSASQAAHSGSWKAWMDGYGSSHTDSVSQTVTIPAGCKASLSFW
                     LHIDTAETTTSSAYDKLTVTANGTSVATYSNLDKNTGYAQKTVDLSAYAGQSVTVKFNA
                     VEDASLQTSFVIDDTAIQTS"
     misc_feature    854..869
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.83"
                     /tool="antismash"
     gene            complement(<1030..1740)
                     /locus_tag="CG736_RS38935"
                     /pseudo=""
     CDS             complement(<1030..1740)
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024758.4"
                     /locus_tag="CG736_RS38935"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="serine protease"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVDRIEVTMAFSCGAGVHQPVARLQSPTRRAMFKRFAAALGAVAV
                     VAGALTLGAAPAQAVQAGDLTSTIALSNCSASLVRYPSSVDTDRAMMLTNGHCLPTMPS
                     AGQVIQNASASRSGTLLNSAGTSLGTVQADKVLYATMTGTDVALYQLTDTFAAVTTKYG
                     ATALTISDTHPVDGSAMYIPSSYWKQVWNCSINGFVDTLREDQWTWRDSLRYSAGCNTT
                     HGTSGSPIVDAASKK"
     misc_feature    1796..1812
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 19.23"
                     /tool="antismash"
     misc_feature    complement(2274..2287)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.27"
                     /tool="antismash"
     gene            complement(2390..3370)
                     /locus_tag="CG736_RS14845"
                     /old_locus_tag="CG736_14800"
     CDS             complement(2390..3370)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009998976.1"
                     /locus_tag="CG736_RS14845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_14800"
                     /product="YafY family protein"
                     /protein_id="WP_100586675.1"
                     /transl_table=11
                     /translation="MRSDRLVATLLLLQRREQVTAAEVSRELDVSERTARRDLDALAMA
                     GVPVYSVQGRGGGWRLVGGARTDLSGLTASEARALFLAVGPASDATPAMKAALRKLVHA
                     LPKPFQVQAEAAAASLVVDPQRWGAGRIEHRPPRFLDELQDAVISGVQVSLGYVDSKGV
                     ETRRTVHPLGIVAKGPVWYLVSDTETGRRIFRIDRVSSADPTGDPVHRPGDFDLAESWN
                     EIAKEVDHKRTPLEVRAVCTPDGIGILRMALGDRLDVGGSTTDGRIEVVIRGPNEYILA
                     GELSGLVEWVEVTGPPEVRDHLASIGNALVERYGRPRTSGDLHPS"
     gene            3487..4428
                     /locus_tag="CG736_RS14850"
                     /old_locus_tag="CG736_14805"
     CDS             3487..4428
                     /NRPS_PKS="Domain: Abhydrolase_1 (31-296). E-value:
                     5.8e-36. Score: 116.3. Matches aSDomain:
                     nrpspksdomains_CG736_RS14850_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971279.1"
                     /locus_tag="CG736_RS14850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_14805"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_100586676.1"
                     /sec_met_domain="PF00561 (E-value: 6.7e-30, bitscore: 99.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.8e-18, bitscore:
                     62.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNQAEFPEPALIQVNGVELEVFEAGRENKGKPIVLCHGWPEHAF
                     SWRHLMPVLAAAGYHVIAPNQRGYGHSSRPTEVTDYDIEHLAGDLVALLDHYGYEDATF
                     VGHDWGAFVVWGLTLLHPDRVNKLINLSLPYQERGETPWIEAMETFLGGDFYFVHFNRQ
                     PGVADAAFDANTSQFLRNLYRKNVPPAPPEPGMAFINLAKAETPLGEPIMSDSDLAVYV
                     SAFETSGFTGGINWYRNLDRNWHQLADADPIVKQPALMIYGDRDFAIPRFERLAEFVPD
                     VEVIGLECGHWIQEEMPEQTNQVISEWLKRQG"
     aSDomain        3580..4374
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CG736_RS14850_Abhydrolase_1.1"
                     /evalue="5.80E-36"
                     /label="CG736_RS14850_Abhydrolase_1.1"
                     /locus_tag="CG736_RS14850"
                     /protein_end="296"
                     /protein_start="31"
                     /score="116.3"
                     /tool="antismash"
                     /translation="KPIVLCHGWPEHAFSWRHLMPVLAAAGYHVIAPNQRGYGHSSRPT
                     EVTDYDIEHLAGDLVALLDHYGYEDATFVGHDWGAFVVWGLTLLHPDRVNKLINLSLPY
                     QERGETPWIEAMETFLGGDFYFVHFNRQPGVADAAFDANTSQFLRNLYRKNVPPAPPEP
                     GMAFINLAKAETPLGEPIMSDSDLAVYVSAFETSGFTGGINWYRNLDRNWHQLADADPI
                     VKQPALMIYGDRDFAIPRFERLAEFVPDVEVIGLECGHWIQEE"
     gene            4680..4877
                     /locus_tag="CG736_RS37090"
                     /old_locus_tag="CG736_14810"
     CDS             4680..4877
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CG736_RS37090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CG736_14810"
                     /product="hypothetical protein"
                     /protein_id="WP_369880198.1"
                     /transl_table=11
                     /translation="MPEGMVLYGIRHFFASNCLTHDIPITDVAEWTGHRSIDVTFKIYR
                     HLMPGSISRAAQVLNVDLAA"
     gene            complement(5379..6182)
                     /locus_tag="CG736_RS14860"
                     /old_locus_tag="CG736_14815"
     CDS             complement(5379..6182)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018570569.1"
                     /locus_tag="CG736_RS14860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_14815"
                     /product="ECF transporter S component"
                     /protein_id="WP_100586677.1"
                     /transl_table=11
                     /translation="MSAAVRAVRVPLRARAVIACAAFAGLVAFLWPFVVAPGRFGSAYA
                     PPLIFGALLVLILAVVISEIASGGIDAKALAMLGVLSAVNAGLRPLGAGTAGVETVFFL
                     LVLAGRVFGPGFGFTLGCTSLFASALLTGGVGPWMPYQMFGCAFVGLIAGLLPRLRGRA
                     EVLLLAGYGVLSGYLFGFLLNLSFWPFSLDPHSSIAYLPGLPFTEQWHRYLLFDLATSL
                     GWDTGRAVTTGLAVLIAGPAVLAVFRRAARRAAFEAPVHFSATPR"
     gene            complement(6179..7822)
                     /locus_tag="CG736_RS14865"
                     /old_locus_tag="CG736_14820"
     CDS             complement(6179..7822)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965690.1"
                     /locus_tag="CG736_RS14865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_14820"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_100586678.1"
                     /transl_table=11
                     /translation="MIRFDQVSVVYHGASEPVLRDVELTVPEGELCLVVGRTGSGKSTL
                     LGAVNGLVPHFTGGTLHGRVTVDGRDTAHHPPRELADVVGVVGQDPLAGFTTDTVEEEL
                     AYAMEQLAVPPEVMRKRVEETLDLLGLAELRHRALHELSGGQQQRVAIGSVLTAHPRVL
                     VLDEPTSALDPTAAEEVLAAVTRLVHDLGVTVLLAEHRLERVVQYADRVVYLPGDGTVR
                     DGLPAEVFRDTAIAPPVVQLGRLAGWRPLPLSVRDARRAAAPLRERLAARPVPPVRSAR
                     SPGERVLRAERVVVRHGRQVAVREVSLDLAAGQVVALMGRNGSGKSSLLWALQGSGARQ
                     GGTVLVAGKDPKRVPAAEARRLVGLVPQTPTDLLYLDSVDAELAQADRESAPAPDRGAR
                     ALLDALAPGVPGHLHPRDLSEGQQLALVLAVQLAAAPPVVLLDEPTRGLDYPAKDALIA
                     IVDRLAAEGRAVVVATHDVEFAAAAADRVVVLAEGGSVADGPTPAVITASPVFAPQTAK
                     ILAPLPWLTVHQVAAALAEPSPEPKPEADR"
     gene            complement(7819..8991)
                     /locus_tag="CG736_RS14870"
                     /old_locus_tag="CG736_14825"
     CDS             complement(7819..8991)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515012.1"
                     /locus_tag="CG736_RS14870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_14825"
                     /product="CbiQ family ECF transporter T component"
                     /protein_id="WP_100586679.1"
                     /transl_table=11
                     /translation="MSTRRAADSGKRIPRDLHPLAWWAWALALGTAASRTTNPLLLLLV
                     LAVLGFVVTARRTEAPWARGFKYYLWLALTIVAIRVLFRCVFATGVTPDDHVLLTLPHL
                     PTPAWYAGISIGGPVSLEAVLSSMVDGLRLACLMCCIGAANTLANPKRALRVLPGALYE
                     LGVAVTVSLSVAPQLVASAQRVRRARRLRAARAKGLHALRGIVVPVLSDALDRSLHLAA
                     AMDSRGYGRSGSASPSSRRATGALLLAGMAGLCTGLYGLLDGTAPAWLGLPALAAGSAL
                     CVAGLALGGRRVRRTTYRPDPWRGAEWGVAGCGLAAAVLLCGSVGYDATALNPSLYPLS
                     WPSLPVVPVLALLLAGTAGVLAPPPGRPPTAAAPPSLRPVSDRELSEVSE"
     gene            complement(8988..10004)
                     /locus_tag="CG736_RS14875"
                     /old_locus_tag="CG736_14830"
     CDS             complement(8988..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378694.1"
                     /locus_tag="CG736_RS14875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_14830"
                     /product="hypothetical protein"
                     /protein_id="WP_100586680.1"
                     /transl_table=11
                     /translation="MSGRFARPARLGAAAGTVLAVALGGPAPSPARAEALPMDQCTTSR
                     NVVLAIDFGRWGGPVLRACGSTPTTGYQLLNQGGWKTAGTQHDGPGFICRIGYSGYQGG
                     KQFPPPDQEKCMLTPPATAYWSYWHADPGQNTWSYSQLGAMSYHPVPGSVDAWVFGETD
                     IGGTRGGPSFSPDSVRALNSAPGGSGSGGGTGGTGGGTGGSGTSGGSAGGSSGGGSGGG
                     GKAPAPTSGAGNDPTGGGSSSEGPTADPDPEPTGSATAAGSPSPKASPSPSSDPTGSPS
                     PTASGASPAPVDAVPLADTPRPSSGSIAPVVAGVVLVAALGTATAAVAVRRRRADRE"
     gene            complement(10001..12820)
                     /locus_tag="CG736_RS14880"
                     /old_locus_tag="CG736_14835"
     CDS             complement(10001..12820)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965687.1"
                     /locus_tag="CG736_RS14880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_14835"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_100586681.1"
                     /sec_met_domain="T2TS (E-value: 2.3e-16, bitscore: 53.8,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVNHSSTSTHPSRTRGRRPAAALLATLVAAATTGTLLLGHPGTA
                     AADPVEQCTATTGAIVAVDFSPWGGGLVRGCDAHPTTGMNLLHNAGFTTAGTVHDGPGF
                     ICRIGTGAFATGTQYPTAATEPCTTTPQGSAYWSYWIAEPGATAWTYSRFGADGQKPKA
                     GEVEAWVYGATDLGGTTGGPKFTPDEVRAKNAASPSPSPSPSASGGPSGSPSPSPGGSS
                     GTGAPPGRTADPAAAAAWLAAQLTDGDHMENWAFEGPDFPRTALTALSLAGSGTQDAAL
                     RKVAAFLAAHADAFLFPNGASAGAAPDARAAALLALVAEATGGDPRSFGGRDLVAALTD
                     HVCDAAGQGGKCSAAGDFQGAANPWTQAMGVIALARAGVVPAPAVLDRFAGVQCADGGF
                     AGTLIRPGQYCESDPLSTAETVIALRLAGGHQPVADRGVAWLTAQQGADGAFVPYAGAS
                     PETLSTAVAAQALHAAGRTAEADRATAWLAARQNADGGLGPDEWTPDSEAPATEQAILA
                     LTGTDPATVLRRVNAPQPARTPDLARAGAYLTDRARLIDGHYYEGFTDFADFGLTIDTA
                     YALAATGTDDAALRRITDFLDQQGKDRSERSVNDWTAIGTEWAGGGSVAKEALLAEIVG
                     RDPRHFGGQDLITALDRMVCDHADVNAGCDGPGNYQWAQSVFSQALGVMAQVRAGHAEQ
                     AGPAVAYLRGLQNADGSWPSLIPNSRTPDVDSTAIAAMALDLLPDRESRQAVERALGWL
                     AARQLPDGGFPGSAGNSVNSAALAVQGLSLRQDAYAARIARATEFLAGQQNADGGFTVA
                     ADGPRTSDLRASAQAAGGVTGRSFGTLSHKLDDSTPGEPSGSPSPSSSASPSASASAEP
                     TGSPSPSRSTSGGTVVDTSTGGGSTSSGLAFTGTDVLELVVPGLLLTVGGGAVLVAFRR
                     RAKADGGSR"
     misc_feature    complement(12852..12862)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     regulatory      complement(12921..13054)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(13027..13042)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     regulatory      13185..13333
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            13444..14844
                     /locus_tag="CG736_RS14885"
                     /old_locus_tag="CG736_14840"
     CDS             13444..14844
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550956.1"
                     /locus_tag="CG736_RS14885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_14840"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_100586682.1"
                     /transl_table=11
                     /translation="MTRRSTTALAAVALAAGALLGTAVPAQAATPAQIATSKTNGVAYL
                     KTLQAADGSYVTSGGLSNEWAFSALAAAGTAAVDVLPGADPAKNARTVYRGQLAAATWP
                     GASPVVTDYERAILNSYAAGIDPARVGAGRNLIADLAAYWQSAEPGYWGPSGNFNGTVF
                     GLLALGNARTQSGSQRVPQTLLDASAAAVRANQHTDGGWNYSKAAGDPTALAQASDIDM
                     TGAAMASLCAAGVPSTDSAITSAASFLAANLNANGSFAAMWGPNTDSNGWAVSGLNACG
                     INPQGAAFTSGSGKTPVDYLIAQQFNPGGGFKYQSTDTTPSAYASVDGLRAVAGGGFTA
                     TPPTPVTSGAPTWVATTAFTSGTAARIALTVDNGTGNLKVCAVTLTPTGSTTTLGAVLD
                     AAATATPSGCVTGVTPSSGSGAITAVNGTANAGANSWKVRLDNGTAATATRATTVNAGD
                     TVSLRYGS"
     gene            complement(14832..15407)
                     /locus_tag="CG736_RS14890"
                     /old_locus_tag="CG736_14845"
     CDS             complement(14832..15407)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101: phosphoglycerate mutase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139979.1"
                     /locus_tag="CG736_RS14890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_14845"
                     /product="histidine phosphatase family protein"
                     /protein_id="WP_100586683.1"
                     /transl_table=11
                     /translation="MTVRVMLVAPALGAEGRGARFGDDLPLTDADLAPARTLAVPRADR
                     VLSAPSPRCRQSAGALDLMPADEPCLADLDPGAWRGRPLAELAAAEPESIAAWLSDPGF
                     APPGGESVGALLARVGGWLDALPADTGRVLAVAEPAVVRAAVVHALALPPAAFWRLDVA
                     PLTVTSLSGRAARWNLRCGAPLMPRQLP"
     gene            15659..15877
                     /locus_tag="CG736_RS14895"
                     /old_locus_tag="CG736_14850"
     CDS             15659..15877
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950971.1"
                     /locus_tag="CG736_RS14895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_14850"
                     /product="CbtB-domain containing protein"
                     /protein_id="WP_100586684.1"
                     /transl_table=11
                     /translation="MAHPIAPAAVTTPALTPLSVKAIAPWAAFFGILLLTLLYFVGAEQ
                     GATSLLSGESVHEWVHDGRHLLGFPCH"
     gene            15912..16670
                     /locus_tag="CG736_RS14900"
                     /old_locus_tag="CG736_14855"
     CDS             15912..16670
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139981.1"
                     /locus_tag="CG736_RS14900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_14855"
                     /product="CbtA family protein"
                     /protein_id="WP_100586685.1"
                     /transl_table=11
                     /translation="MNSHTVRNLLVRGMLAGLGAGVLALIVAYLLGEPRVDAAIAFEDS
                     HSHEHGEELVSRTLQSTAGLATGILIYGLALGGIAALAYCFALGRTGRFGPRAGALLLS
                     GAALVAVYLVPFLKYPANPPSVGDPETIGKRTTLYFLMMLLSVLLAVAAVAAGKQLAPR
                     LGNWNATLAAGLGYAALIGLGYVLLPAVNEVPEDFSASLLWQFRVAALAIQLTLWLSFG
                     LLFGHLAERLLLPKPARPANAAAEATPVAN"
     gene            complement(16751..16975)
                     /locus_tag="CG736_RS14905"
                     /old_locus_tag="CG736_14860"
     CDS             complement(16751..16975)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CG736_RS14905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CG736_14860"
                     /product="hypothetical protein"
                     /protein_id="WP_100586686.1"
                     /transl_table=11
                     /translation="MAGRGEVQRIRIGEEVLVVLPEREYEALLANRRQVGGCTARVRAL
                     QHALAEALSRLAAAEGAGAADDGAPDVAQ"
     gene            complement(17047..19365)
                     /gene="metE"
                     /locus_tag="CG736_RS14910"
                     /old_locus_tag="CG736_14865"
     CDS             complement(17047..19365)
                     /EC_number="2.1.1.14"
                     /GO_function="GO:0003871 -
                     5-methyltetrahydropteroyltriglutamate-homocysteine
                     S-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019982020.1"
                     /locus_tag="CG736_RS14910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_14865"
                     /product="5-methyltetrahydropteroyltriglutamate--
                     homocysteine S-methyltransferase"
                     /protein_id="WP_100586687.1"
                     /transl_table=11
                     /translation="MTTKSVAAATVHGYPRQGGNRELKKAIEGYWKGAVTADALLATAA
                     ELRCTNWRQLVGAGITEVPTGDFSLYDHVLDTTVALGAIPPRHRAAYEADPLDGYFAMA
                     RGTQQTPPLEMTKWFDTNYHYLVPELGPDTVFAPDSAKQVGELREALGQGHRARPVLLG
                     PVTYLLLAKPAPGAPDGFEPLTLLDRLLPVYAELLADLRAAGAEWVQLDEPALVQDRTP
                     AELNAAARAYRDLGALTDRPKLLVASYFDRLGEALPVLAKSPVEGLALDFTGPAAGNLA
                     DLAAVGGLPGKRLVAGVVDGRNVWINDLGASLATLATLLGLADRVDVAPSCSLLHVPLD
                     VAAERDLDPQIGRWLAFARQKAAEAALLARALREGRSAITAQLAANRADLASRAASPIT
                     RDPAVRARAAAVTAADTRRDAPYAVRAEAQRARLQLPPLPATTIGSFPQTAELRASRAE
                     LNAGRLEEADYRKRMEDEVREVIAFQEQAGLDVLVHGEPERNDMVQYFAEQLTGYLTTR
                     HGWVQSYGTRYVRPPVLAGDISRPYPMTVDWYTYAQSLTDRPVKGMLTGPVTMLAWSFV
                     RDDQPLADTARQVALALRDEVADLEAAGAAVIQVDEPALRETLPLRRAGRPAYLDWATD
                     AFRLTTAAVRADTQIHTHMCYAEFGDILRAIEELDADVISLEAARSHMQVAHELAAAGY
                     PAEVGPGVWDIHSPRVPSPAETVLLLRLALTAVPAERLWVNPDCGLKTRGWPETRASVE
                     SLVAAARTLRAELQNRRID"
     regulatory      complement(19517..19742)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            19995..20168
                     /locus_tag="CG736_RS36210"
     CDS             19995..20168
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CG736_RS36210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157815589.1"
                     /transl_table=11
                     /translation="MSAEPDRVLVPRAACWVIISGRGRIRSRRPAVTAENVNAAWTGTV
                     APEPTRTDEVSR"
     gene            20165..20410
                     /locus_tag="CG736_RS14915"
                     /old_locus_tag="CG736_14870"
     CDS             20165..20410
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CG736_RS14915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CG736_14870"
                     /product="hypothetical protein"
                     /protein_id="WP_100586688.1"
                     /transl_table=11
                     /translation="MNSWINLDAIWRIVVVGLLTGAGLPALFALGLRLLNPAPLPGRPA
                     TDRPTAGPLGRTLAGLIFAVVLATIGWGVSGIVNHR"
     gene            20640..21554
                     /locus_tag="CG736_RS14920"
                     /old_locus_tag="CG736_14875"
     CDS             20640..21554
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014181745.1"
                     /locus_tag="CG736_RS14920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_14875"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_100586744.1"
                     /transl_table=11
                     /translation="MQFQPVLVTGVGGRVGGVGRAVVDRLRAEGVPVRALVHHDDERAS
                     ALRAVDGVEVVVGDLTRGADVAEALAGCRRAYFGMGVSPAYLEAATTVAAAARESGGFD
                     LLVSISQMTVSQMDLTSRAESRQQRLHWLTEHVLDWSGVPVVHVRPTVFMENPLFARIA
                     LASILRDRTIRLPFGSARTSPVAAADVAEVVARLLLDSAPPSRRVYELTGARSRDMSVI
                     AAEFSAALGRAITYVDVPYEEWLDRDLRTQDLPPHVFEHIATMARLHGENRYDRATNDV
                     AELLGRPPLGFDHFIRNTPGLRP"
     gene            complement(21824..22654)
                     /locus_tag="CG736_RS14925"
                     /old_locus_tag="CG736_14880"
     CDS             complement(21824..22654)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (21-191). E-value: 1e-07. Score:
                     24.0. Matches aSDomain:
                     nrpspksdomains_CG736_RS14925_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018560515.1"
                     /locus_tag="CG736_RS14925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CG736_14880"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_198520503.1"
                     /sec_met_domain="adh_short_C2 (E-value: 4.4e-31, bitscore:
                     103.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPSTPSRSARPGDDDGLTGQTVVVTGAGRGIGLAITEAFLAAGC
                     HVVAGSRTRTEALDTHVEQGANLTVVEVDLATPGGPAGLITEAARLHGGIDVLVNNVGA
                     VRPRVDGFLSVTDEDWDWALSVNLLTAVRTTRAALPHLLASGAGRIVTVSSVNARLPDP
                     LVIDYGAAKAALTNFCKALSKEVGPQGVRVNTIGPGPVETALWQGTDGVAATVGRSRGT
                     GPDDVARAAAAQSATGRFTRPAEVADLVLFLAGPGAANITGADFVIDGGLVDSL"
     aSDomain        complement(22082..22591)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CG736_RS14925_PKS_KR.1"
                     /evalue="1.00E-07"
                     /label="CG736_RS14925_PKS_KR.1"
                     /locus_tag="CG736_RS14925"
                     /protein_end="191"
                     /protein_start="21"
                     /score="24.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVVVTGAGRGIGLAITEAFLAAGCHVVAGSRTRTEALDTHVEQGA
                     NLTVVEVDLATPGGPAGLITEAARLHGGIDVLVNNVGAVRPRVDGFLSVTDEDWDWALS
                     VNLLTAVRTTRAALPHLLASGAGRIVTVSSVNARLPDPLVIDYGAAKAALTNFCKALSK
                     EVGPQGV"
     CDS_motif       complement(22499..22591)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CG736_RS14925_0001"
                     /evalue="2.20E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="CG736_RS14925"
                     /protein_end="52"
                     /protein_start="21"
                     /score="10.7"
                     /tool="antismash"
                     /translation="TVVVTGAGRGIGLAITEAFLAAGCHVVAGSR"
     misc_feature    22650..22665
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.33"
                     /tool="antismash"
ORIGIN
        1 acggcgcccg ggctcgtcgg ccgcgatgcg gagccgggcg aggacgagtc cggcggagcc
       61 accggaagcg ttcgggtggc tccgccgggc tcgtggggct cagctggtct ggatcgcggt
      121 gtcgtcgatc acgaaggacg tctgcagcga ggcgtcctcg acggcgttga acttcaccgt
      181 caccgactgg ccggcgtagg ccgacaggtc gacggtcttc tgggcgtagc cggtgttctt
      241 gtcgaggttc gagtacgtgg cgaccgaggt gccgttcgcc gtgacggtga gcttgtcgta
      301 cgcgctcgac gtggtggtct cggcggtgtc gatgtgcagc cagaagctca gcgacgcctt
      361 gcagccggcc gggatggtga cggtctgcga gacgctgtcg gtgtggctgg agccgtagcc
      421 gtccatccac gccttccacg aaccgctgtg cgcggcctgc gaggcggagt tgtcgaccac
      481 gccggtgctg gtggtccacg gggccgcggt gccggtctcg aagcccgcgt tgccgaggag
      541 ctgcgccggg gtgcaggtgc cctggttcgt ggtgaccgtc caggagaacg tggtggaggc
      601 ggtcttaccg gccgcgtcct tgacggtgac ggtcaccgag gagccgcccg aggtggtggg
      661 ggtgccgctg atcaggccgg tggaggcgtt gatcgacagg ccggcgggca ggccggtggc
      721 cgagtagctc agcggggcgg tgccgccgga cgcctggatc tgcaggctga ccgaaccgtt
      781 gaccacggtg gactggttgc ccgggttggt caccgacacg gccgcgccgg ccggcttggt
      841 cagcaggcag ccgctgacgg tcaggtcgat cacccggccg gtgcccaggc aggtggtgaa
      901 ccagtaggtc tcctcaccgt agctctggcc cttggtgacg gtcgtggtgc cgtccgcggc
      961 cacctcgcac gggttgttca gggtgcacat cgcgccgtcg tcgttgccgg tgttgttgat
     1021 gccgacgacc ttcttgctgg cggcgtcgac gatgggcgaa ccggacgtgc cgtgtgtggt
     1081 gttgcagccc gcgctgtaac gcagcgagtc gcgccaggtc cactggtcct cgcgcagggt
     1141 gtcgacgaac ccgttgatcg agcagttcca cacctgcttc cagtacgagg acggtatgta
     1201 catcgccgac ccgtcgaccg gatgggtgtc gctgatcgtc agcgccgtcg ccccgtactt
     1261 ggtggtgacg gcggcgaagg tgtcggtgag ctggtacagc gcgacatcgg tgccggtcat
     1321 cgtcgcgtac agcaccttgt ccgcctggac ggtgccgagc gaggtgccgg cggagttgag
     1381 cagcgtgccg ctgcggctgg cgctcgcgtt ctggatgacc tggccggccg acggcatggt
     1441 cggcaggcag tggccgttgg tcagcatcat cgcccggtcg gtgtccaccg aactcgggta
     1501 gcggaccagc gaggcggagc agttgctcag cgcgatggtg gaggtcaggt cgcctgcctg
     1561 aacggcctgc gcgggagcgg caccgagggt cagggcaccc gcgacgaccg cgaccgcgcc
     1621 gagcgcggcg gcgaatctct tgaacatggc tctccttgtg ggggattgca ggcgtgcgac
     1681 cggttggtgc acgcccgcgc cgcacgaaaa tgccatggtc acttcaatgc ggtcaaccat
     1741 gtcgacggaa ctcgcggtcg aagtcctccg cagacgcggg tgttggactg ggcacttgat
     1801 gtaccgtcac atcccgtttg tcgcagcccg tcaggcgcgg aagcgctgcg cgccctcgcc
     1861 cagagggccg cggggaaggc ggcaggcggg tcgggcctcg ggacggtgat cccgtcgatc
     1921 ggcccggcgg tcctcaggga ctccagcgcc accggcggca tcgtccaggt cgagcagggc
     1981 gttccaccgc ccggcggcac tcccgtcggc gagcaggcac tccagcagcc tggcagtgac
     2041 ggtgacgtcc gacatcgccc ggtgacggtc ggccgggcgg gcgatgccgt agtggatcag
     2101 gaggttgtcg aggctggtag gagcccagac cgggggtgag ggccttggcg aggcggatgg
     2161 tgtcgagcag cggcgtggcg gccagggcag ggcagcgccc ggcctgacgg gcgatcatcc
     2221 cggcctcggt gggggcatga tgggccacca gccggtaggg cggcgcggtc aggtgcgtgt
     2281 ccatgcgagc caggccggca gacccgctga ctcgtgacca ggcgactgcc ggaacggaca
     2341 aacccgccct gttgagcgga actgttctcg aagctctgcc tcgtccgctt caagacgggt
     2401 gaaggtctcc gctggtgcgc ggccggccgt atcgttcgac gagggcgttg ccgatcgagg
     2461 ccaggtggtc tcggacctcc ggagggccgg tcacctcgac ccattcgacg agcccggaga
     2521 gctcgccggc gaggatgtac tcattggggc cgcggatcac gacctcgatg cggccatcgg
     2581 tcgtggaacc tcccacgtcg agccggtcgc cgagcgccat ccggagtatg cctatgccgt
     2641 cgggtgtgca taccgcccgg acctccagcg gcgttcgttt gtgatcgacc tctttggcga
     2701 tctcgttcca gctctcggca aggtcgaagt ccccgggtcg gtgcacaggg tcgccggtcg
     2761 ggtcggcgga cgacacgcgg tcgatccgga agatccgtcg gccggtctcg gtgtcggaga
     2821 cgaggtacca cacaggacct ttggcgacga tgcccagcgg gtggacggtt ctccgggtct
     2881 cgacgccttt gctgtcgacg tagccgagcg acacctggac gccgctgatc accgcgtcct
     2941 ggagttcgtc gaggaagcga ggtggccggt gctcgatccg gcccgccccc cagcgctgcg
     3001 ggtctacgac cagcgacgcc gccgctgcct cggcctgcac ctggaagggc ttcggtaggg
     3061 catggacgag cttgcgcaga gctgctttca tcgccggcgt cgcatccgag gccggaccga
     3121 cagccaggaa cagggcgcgg gcctcactgg cggtcaaccc ggacaggtcg gtacgagcgc
     3181 cgcccacgag gcgccagccg ccgccccggc cctgtacgga gtacacgggc accccggcca
     3241 tggccagggc gtcgaggtca cggcgggcgg tgcgctcgga gacgtccagc tctcgggaga
     3301 cctctgcggc tgtcacctgc tcgcgccgtt ggagcaggag gagtgtggcc accagccgat
     3361 cggatcgcat gcagacaaag ctctcatgaa aaccggtcat ggggtgaccg gtttggggag
     3421 cacgatggcg acacggcctc atcgaggagg tcgaccgccg gcgaacgccc ccagagagga
     3481 aatgcagtgc tcaatcaagc ggaatttccc gagcccgccc tcatccaggt caacggtgtg
     3541 gagctcgaag tcttcgaggc gggccgagaa aacaagggca agcccatcgt gctctgccac
     3601 ggctggccgg agcacgcctt ctcctggcgt cacctgatgc ccgtcctcgc agcggccggc
     3661 taccacgtca tcgcaccgaa ccagcggggt tatggtcact catcccgccc gaccgaggtg
     3721 acggactacg acatcgagca cctggcgggt gacctcgtcg cgctcctgga ccactacggc
     3781 tacgaggacg ccaccttcgt cggccatgac tggggtgcgt tcgtcgtctg ggggctgacc
     3841 ctgttgcacc ccgaccgggt gaacaagctg atcaacctga gcctgcctta tcaggagcgc
     3901 ggagaaacgc cgtggatcga ggccatggaa acctttctcg gcggcgactt ctacttcgtc
     3961 cacttcaacc ggcagccggg cgtcgcggac gccgcattcg atgccaacac ctcccagttc
     4021 ctccgcaacc tctaccggaa gaacgtgccc cccgcacccc ctgaaccggg catggcattc
     4081 atcaacctcg ccaaggcgga aacaccactc ggtgagccca tcatgagcga cagtgatctg
     4141 gccgtctacg tctccgcgtt cgagacgtcc ggattcacgg gcggcatcaa ctggtaccgg
     4201 aacctcgacc gcaactggca ccagctggcg gacgcggacc cgatcgtcaa gcagcccgcc
     4261 ctcatgatct acggcgaccg ggacttcgcg atcccgaggt tcgaaagact ggcagagttc
     4321 gtgcccgacg tggaagtgat cggcctggaa tgcggtcact ggatccagga ggaaatgcca
     4381 gaacagacca accaggtgat ttcggaatgg ctgaagcggc agggctagtg tcctgcgatc
     4441 cggttcgcat cacctgaagg ccgagttctc acatcacacc gatgactgcc ggacgtgggg
     4501 gcgggccagg tcgcgcggcc tcctcgtcag ggcttcaagg tcatctggta gcgggtttca
     4561 ggctcaccct ggggcggaat ccaacgtccc caccgtggct cgtcgagccc gagcgactga
     4621 cccaagcccc gacaagtgtc aaccagtggc agcggctcac acctgacggc acgtccgaga
     4681 tgccggaggg catggtgctg tacggcatcc ggcacttctt cgcctcgaac tgcctcaccc
     4741 acgacatccc gatcaccgat gtcgcggagt ggacgggcca ccgcagcatc gacgtgacgt
     4801 tcaagatcta ccgccatctc atgcccggct cgatcagccg cgccgcccaa gtgctgaacg
     4861 tggatctcgc ggcctgaggt gaaccatggt ttcggcccgt caggacatgc ggcgggccga
     4921 aacccgaggt gacgccggga ggcgctgctg tttgatccag gactggacct cggacacctt
     4981 gagtgcggcc gtcgccaccg acgatgctgc cgcagaccgg cacggggtac tcggttccgg
     5041 cttggtcgtg gacggcggcg atccggcacc gccgagtgat cacaacgggt ttccggcgcc
     5101 gagctgatcg atacggcagt cagggcggcg gagtcaccgc agtgctgcgc gcatctgggc
     5161 cggcccggtc tccgtcgccc acgtgcggag aacaggcgga ccatggccgt gcccctcaag
     5221 tctgtgcacc gtcagccgac cgccccagcc ctcctactgg tctccgccgc ctttccggca
     5281 gcggccttcg cgatccgccc atcgccctcg cacgccgccc ctgctgctgc agcccggggt
     5341 gtgcctcggt ctggtcggtg gaggtggtgc ggcggggcct accggggcgt ggcggagaag
     5401 tggacgggtg cttcgaaggc ggcgcggcgg gcggcgcggc ggaagacggc gagcacggcg
     5461 gggcccgcga tcagtacggc caggccggtg gtgacggcgc gtccggtgtc ccagccgagc
     5521 gaggtggcca ggtcgaacag gaggtagcgg tgccactgtt cggtgaacgg gaggccgggc
     5581 aggtaggcga tcgagctgtg cgggtcgagg gagaacggcc agaaggagag gttgagcagg
     5641 aaaccgaaca ggtagccgga cagcaccccg tagcccgcca gcagcagtac ttcggcccgg
     5701 ccgcgcagcc ggggcagcag gccggcgatc aggccgacga acgcgcagcc gaacatctgg
     5761 tacggcatcc acgggccgac gccgccggtg agcagcgcgg acgcgaacag ggaggtgcag
     5821 ccgagggtga acccgaagcc gggcccgaag acgcggccgg ccaggacgag gaggaagaag
     5881 acggtctcca ctccggcggt tccggcgccg agcgggcgca ggccggcgtt gacggccgag
     5941 agcacgccca gcatggccag cgccttggcg tcgatgccgc ccgaggcgat ctccgagatc
     6001 accacggcca ggatcagcac cagcagcgcg ccgaagatca gcggaggtgc gtacgcggac
     6061 ccgaaccggc cgggggcgac gacgaacggc cacaggaagg cgaccagccc ggcgaacgcg
     6121 gcgcacgcga tcacggcccg ggcccggagc gggacgcgga cggcccggac ggcggcgctc
     6181 accggtcggc ctccggcttc ggttccggag acggttcggc gagggcggcg gcgacctggt
     6241 ggaccgtcag ccaggggagc ggggcgagga tcttggcggt ctgcggggcg aagaccggag
     6301 acgcggtgat cacggcgggc gtcgggccgt cggcgacgct cccgccctcg gccagcacca
     6361 ccacccggtc cgcggcggcg gccgcgaact cgacgtcgtg ggtggcgacg accacggccc
     6421 ggccctcggc ggcgaggcgg tcgacgatgg cgatcagggc gtccttggcg gggtagtcca
     6481 gtccgcgggt gggctcgtcc agcaggacga cgggcggggc ggcggcgagt tggacggcca
     6541 ggacgagggc gagctgctgg ccctcggaca ggtcgcgcgg gtgcaggtgg ccggggacac
     6601 cgggggccag ggcgtcgagc agggcgcggg ccccgcggtc cggtgcgggc gcggactccc
     6661 ggtcggcctg ggcgagttcg gcgtccacgc tgtccaggta gagcaggtcc gtcggggtct
     6721 gcgggacgag cccgaccagc cgccgggctt cggccgccgg cacccgcttg gggtccttcc
     6781 cggcgaccag gaccgtgccg ccctgccgag cgcccgagcc ctggagcgcc cacagcagcg
     6841 aggacttccc ggagccgttg cgccccatca gcgccaccac ctgacccgcc gccaggtcga
     6901 gcgacacctc ccggacggcg acctgccgtc cgtgccgaac cacgacccgc tccgcgcgca
     6961 gcacccgctc gcccgggctg cgcgcggagc gtaccggcgg caccggccgg gcggccagcc
     7021 gttcgcgcag cggcgcggcg gcccggcggg cgtcgcgcac cgacagcggc agcggccgcc
     7081 agccggccag ccgcccgagc tggacgaccg gcggggcgat cgcggtgtcc cggaagacct
     7141 cggccgggag gccgtcgcgc acggtgccgt caccgggcag gtacaccacc cggtccgcgt
     7201 actgcaccac gcgttccagc cggtgctcgg ccagcagcac agtgacgccg aggtcgtgca
     7261 ccagccgggt gacggcggcc agcacctcct cggcggccgt cgggtcgagc gccgaggtcg
     7321 gctcgtccag caccaggacg cgggggtgcg cggtgagcac cgagccgatc gccacccgct
     7381 gctgctggcc gccggacagc tcgtgcagcg cccggtgccg cagctcggcc aggcccagca
     7441 ggtcgagggt ctcctcgacg cgcttgcgca tcacctccgg cgggactgcc aactgctcca
     7501 tcgcgtaggc cagttcctcc tccaccgtgt cggtggtgaa cccggcgagc gggtcctgcc
     7561 ccaccacgcc gaccacgtcg gcgagttcgc gcggcgggtg gtgcgcggtg tcccgcccgt
     7621 cgaccgtcac ccgcccgtgc agggtgccgc cggtgaagtg cggcaccagc ccgttcaccg
     7681 cgcccagcag cgtcgacttg ccggagccgg tccggcccac gaccaggcac aactcgcctt
     7741 cggggacggt cagttcgacg tcccgcagga ccggctcgga cgcgccgtgg tacaccacgg
     7801 acacctggtc gaaacggatc actcggacac ctcggagagt tcacggtcgg agacgggacg
     7861 aagagagggc ggcgcggccg ccgtcggagg gcgtcccggc ggcggggcca gtacgcccgc
     7921 cgtccccgcc agcagcaggg ccagcaccgg gacgacggga agggagggcc aactcagcgg
     7981 gtagagagac gggttgagcg cggtcgcgtc gtagccgacc gacccgcaca gcagcaccgc
     8041 cgcggccagc ccgcagcccg ccacccccca ctcggcgccc cgccacggat ccggccggta
     8101 cgtggtgcgc cgcacccgcc gcccgcccag cgccaggccc gccacgcaca gcgccgaccc
     8161 ggccgccagc gcgggcaggc ccagccaggc cggggccgta ccgtccagca gcccgtacag
     8221 gcccgtgcac agaccggcca tgcccgccag cagcagcgcg cccgtggccc gccgcgagga
     8281 aggcgaagcc gaccccgaac ggccgtaacc gcgcgagtcc atggccgccg ccaggtgcag
     8341 cgagcggtcc agcgcgtcgc tcagcaccgg caccacgatg ccgcgcagcg cgtgcaggcc
     8401 cttcgcccga gcggcccgca accgtcgggc ccggcgcacc cgttgggcgc tggccaccag
     8461 ctgcggggcg acgctcagcg acaccgtcac cgccaccccc agctcgtaca gcgcgcccgg
     8521 cagcacccgc agcgcccgct tcgggttggc cagcgtgttg gccgcgccga tgcagcacat
     8581 caggcaggcc agccgcagcc cgtccaccat cgaggacagc accgcctcca gcgacaccgg
     8641 cccgccgatc gagatccccg cgtaccaggc gggcgtcggg aggtgcggca gggtcagcag
     8701 cacgtggtcg tccggcgtca cccccgtggc gaacacgcac cggaacagca cccggatcgc
     8761 cacgatcgtc agcgccagcc acaggtagta cttgaagccg cgcgcccacg gggcctcggt
     8821 gcgccgcgcg gtgaccacga agcccagcac cgccaggacc agcaggagca gcagcggatt
     8881 ggtggtccgc gacgccgccg tgcccagcgc cagcgcccac gcccaccagg ccagcggatg
     8941 caggtcgcgc gggatccgct tgccggagtc ggccgcccgg cgggtgctca ctcgcggtcc
     9001 gcccggcggc ggcgcaccgc cactgccgcc gtcgcggtgc ccagcgcggc caccagcacc
     9061 acgcccgcca ccaccggggc gatcgaaccg gaggacggac gcggggtgtc cgcgagcgga
     9121 acggcgtcca ccggggcggg ggaggcgccg ctcgcggtgg gtgaggggct gccggtcggg
     9181 tcggaggagg gcgacggcga cgccttcggg ctcggggagc cggcggcagt cgcgctgccg
     9241 gtcggctccg ggtcggggtc ggcggtcggc ccttcgctcg aacttccgcc gccggtgggg
     9301 tcgttgcccg ccccggacgt cggggccggg gccttgccgc ccccgccgga gccgccgccg
     9361 gacgatccgc ccgcgctgcc gccgctcgtg ccgctaccgc ccgtaccgcc gccggtgcca
     9421 ccggtgccgc cgcccgaacc cgagccgccc ggtgccgagt tgagggcgcg caccgagtcg
     9481 ggggagaagg acgggccgcc ccgggtgccg ccgatgtcgg tctcgccgaa cacccacgcg
     9541 tcgacgctcc ccggtaccgg gtggtagctc atggcgccca actggctgta ggaccaggtg
     9601 ttctggcccg gatcggcgtg ccagtacgac cagtacgcgg tggccggcgg ggtcagcatg
     9661 cacttctcct ggtcgggcgg cgggaactgc ttgccgccct ggtagccgct gtacccgatc
     9721 cggcagatga agcccgggcc gtcgtgctgg gtgccggccg tcttccagcc gccctgattg
     9781 aggagttggt aaccggtggt gggcgtgctg ccgcaggcgc gcagcaccgg gccgccccac
     9841 cggccgaagt cgatcgccag caccacgttc cgactggtcg tgcactggtc catcggcagc
     9901 gcctccgccc gcgcgggtga cggggccggc ccgccgagcg ccacggccag gaccgtcccc
     9961 gcggccgcgc ccagccgggc cggccgggcg aaccgcccgc tcaccgggag cccccgtcgg
    10021 ccttggcccg ccgccggaag gcgaccagca ccgcgccgcc ccccaccgtc aacaacagcc
    10081 ccggaacgac gagttcgagc acatcggtac cggtgaacgc cagcccggag gaggtcgacc
    10141 cgccgcccgt cgaggtgtcc accaccgtgc cgccggacgt gctccgagag ggggaggggg
    10201 acccggtcgg ttccgcggag gcggaggcgg agggcgacgc ggaggaggac ggcgacgggg
    10261 agccgctggg ctcgccggga gtgctgtcgt ccaacttgtg gctgagcgtg ccgaaggagc
    10321 ggccggtgac cccgcccgcc gcctgggcgg aggcgcgcag gtcggaggtg cgcgggccgt
    10381 cggcggcgac ggtgaaaccg ccgtcggcgt tctgctgccc ggcgaggaac tcggtggccc
    10441 gggcgatccg ggccgcatac gcgtcctggc gcaggctcag accctggacg gcgagcgcgg
    10501 ccgagttgac cgagttgccc gccgagccgg ggaaaccgcc gtccggcaac tgccgggcgg
    10561 ccagccagcc gagggcccgc tcgacggcct gcctgctctc ccggtcgggc agcaggtcca
    10621 gggccatcgc cgcgatcgcg gtggaatcca cgtccggggt acgggagttg gggatcaggc
    10681 tgggccagga gccgtccgcg ttctgcagcc cgcgcaggta ggcgacggcc ggcccggcct
    10741 gctcggcgtg ccccgcccgg acctgggcca tcacgccgag ggcctgcgag aacaccgact
    10801 gcgcccactg gtagttgccc ggcccgtcgc agcccgcgtt cacgtcggcg tggtcgcaga
    10861 ccatccggtc cagggcggtg atcaggtcct gtccgccgaa gtgccgcggg tcgcgtccga
    10921 cgatctcggc gagcagcgcc tccttggcga ccgagccgcc gccggcccac tcggtgccga
    10981 tcgccgtcca gtcgttgacg gaccgttcgg agcggtcctt gccctgctgg tcgaggaagt
    11041 cggtgatccg gcgcagcgcc gcgtcgtccg tgccggtggc ggccagcgcg tacgcggtgt
    11101 cgatggtcag gccgaagtcg gcgaagtcgg tgaagccctc gtagtagtgg ccgtcgatca
    11161 ggcgggcgcg gtcggtcagg taggcgccgg ccctggcgag gtcgggggtg cgggcgggct
    11221 gcggggcgtt gacccgccgc agcacggtgg ccgggtcggt gccggtgagg gcgaggatcg
    11281 cctgctcggt ggcgggcgcc tccgagtccg gggtccactc gtcggggccg aggccgccgt
    11341 cggcgttctg ccgtgcggcc agccaggcgg tggcccggtc ggcctcggcg gtgcgcccgg
    11401 cagcgtgcag ggcctgagcc gcgacggcgg tggacagggt ctcgggggaa gcgcccgcgt
    11461 acggcacgaa cgcgccgtcg gccccctgct gggcggtcag ccaggccacc ccgcggtcgg
    11521 ccaccggctg gtggccgccc gccagtcgca gcgcgatcac ggtctcggcg gtggacagcg
    11581 ggtcggactc gcagtactgg ccggggcgga tcagcgtgcc ggcgaagccg ccgtcggcgc
    11641 actgcacccc ggcgaaccgg tccagcacgg cgggcgccgg gacgaccccg gcgcgggcca
    11701 gcgcgatcac gcccatcgcc tgcgtccacg ggttggccgc gccctggaag tccccggcgg
    11761 cgctgcactt cccgccctgc ccggcggcgt cgcagacgtg gtcggtgagc gccgcgacca
    11821 ggtcgcggcc gccgaacgag cgcgggtcgc ccccggtggc ctcggcgacc agcgccagca
    11881 gcgcggcggc ccgggcgtcg ggcgcggcgc cggccgacgc gccgttcggg aacaggaacg
    11941 cgtcggcgtg tgcggccagg aacgcggcga ccttgcgcag cgccgcgtcc tgggtgccgg
    12001 agccggccag cgagagcgcg gtcagcgcgg tccgcgggaa gtccgggccc tcgaacgccc
    12061 agttctccat gtggtcgccg tccgtcagct gcgccgccag ccaggccgcg gcggcagccg
    12121 gatcggcggt gcggccgggc ggggcgccgg tgcccgaact cccgccgggc gacgggctcg
    12181 ggctgccgga ggggccgccg ctcgcactgg gcgacgggga cggggacggg ctggcggcgt
    12241 tcttcgcccg cacctcgtcc ggggtgaact tcggcccgcc ggtggtcccg ccgaggtcgg
    12301 tcgcgccgta cacccaggcc tcgacctcgc cggccttcgg cttctggccg tcggcgccga
    12361 agcggctgta cgtccaggcg gtggcgccgg gttcggcgat ccagtacgac cagtaggcgc
    12421 tgccctgcgg ggtagtggtg cagggttcgg tggcggcggt cgggtactgg gtgccggtgg
    12481 cgaacgcacc ggtgccgatc cggcagatga agccggggcc gtcgtgcacg gtgcccgcgg
    12541 tggtgaaccc ggcgttgtgc agcaggttca tgccggtggt cgggtgggcg tcgcagccgc
    12601 ggaccaggcc gccgccccag ggggagaagt cgaccgcgac gatcgcgccg gtggtggcgg
    12661 tgcactgctc gaccgggtcg gcggccgccg tgcccgggtg tccgagcagc agggtgccgg
    12721 tggtggcggc cgcgacgagc gtcgcgagca gggcggcggc cgggcggcgg ccacgggttc
    12781 tggacgggtg cgtgctggtg ctgctgtggt tgaccctcac cggtgactcc ctgatcgggt
    12841 cgtggcgggg tgtgacaagg cagcggacgg cggactggcc cccgtaccga ctgcgtcgta
    12901 gtccgcgacg acgcatgtgg tgctgacgaa cccccggtgg caggcattcc ggctcccccg
    12961 ccgcacgggc agggctacgg ttgcgggtca gcgccggatt cggaccggct tcccctgacc
    13021 tccgaggtgg aaaacccgtt catcagacca cgtgagctga gggggcgtca acgcgcccgg
    13081 cagccagtcg aagtgcgccc ggagcgctcg gagtggtgcg caactaccgc ttgatcggcg
    13141 gaggttgacc ggtaggaccg acggctcgcc ggagtcgtgt cgggtacgtc accctgtcgg
    13201 ccggcctgct gcgtggggta ccgtccgcgg tggccgagca ggggaacccg gtgggagtcc
    13261 gggactgacg cgcaacggtg aggggccttc acacgcccga gtccgaatgc ctgccggccg
    13321 tgcaccacga gcgaaagcca cccacgcgat ccgggcggcg gccgccccgg actccggccg
    13381 gacgccagcg cgttccgccg gtgcgacggg gacgcgtcgg cgccccgacc caaggagtcc
    13441 gttgtgaccc gtcgttccac caccgccctg gccgccgtcg ccctcgccgc gggcgcgctg
    13501 ctgggcaccg cagtccccgc gcaggccgcc acccccgcac agatcgccac ttcgaagacc
    13561 aacggcgtcg cctacctgaa gaccctccag gccgccgacg gcagctacgt cacctccggc
    13621 gggctgtcca acgagtgggc gttcagcgcg ctcgccgccg ccgggaccgc cgccgtggac
    13681 gtgctgcccg gcgccgaccc cgccaagaac gcccgcaccg tctaccgcgg ccaactcgcc
    13741 gccgccacct ggcccggcgc gtccccggtc gtcaccgact acgagcgggc catcctcaac
    13801 tcctacgccg cgggcatcga cccggcccgg gtcggcgcag gccgcaacct gatcgccgac
    13861 ctcgccgcgt actggcagag cgccgaaccc ggctactggg ggccgtccgg caacttcaac
    13921 ggcaccgtct tcggtctgct cgcgctcggc aacgcccgta cccagagcgg gagccagcgt
    13981 gtcccgcaga cactgctgga cgcctcggcc gccgccgtcc gcgccaacca gcacaccgac
    14041 ggcggctgga actacagcaa ggccgccggc gacccgaccg cgctcgccca ggcctcggac
    14101 atcgacatga ccggcgccgc gatggcctcg ctgtgcgccg ccggcgtgcc cagcaccgac
    14161 agcgcgatca cctccgccgc gagcttcctg gccgccaacc tgaacgccaa cggctcgttc
    14221 gccgccatgt ggggccccaa cacagactcc aacggctggg cggtctccgg gctgaacgcc
    14281 tgcggcatca acccgcaggg cgccgccttc accagcggca gcggcaagac ccccgtcgac
    14341 tacctgatcg cccagcagtt caaccccggc ggcggcttca agtaccagtc caccgacacc
    14401 acgccgtccg cgtacgcctc ggtcgacggc ctgcgcgcgg tggccggcgg cggcttcacc
    14461 gccaccccgc ccacccccgt cacctccggc gcccccacct gggtcgccac cacggcattc
    14521 acctccggca ccgccgcccg gatcgccctc accgtcgaca acggcaccgg aaacctcaag
    14581 gtctgcgccg tcaccctcac cccgaccggc tccaccacca ccctcggcgc cgtcctggac
    14641 gccgccgcca ccgccacccc cagcggctgc gtcaccggcg tcacgccgtc cagcggcagc
    14701 ggcgcgatca ccgccgtcaa cggcaccgcc aacgcgggcg ccaacagctg gaaggtccgc
    14761 ctcgacaacg gcaccgccgc caccgccacc agggccacca ccgtcaacgc cggcgacacc
    14821 gtctccctgc gctacggcag ctgacgcggc atcagcggcg cgccgcagcg caggttccag
    14881 cgcgcggcgc gcccgctgag cgaggtgacg gtgagcgggg cgacgtccag ccgccagaac
    14941 gcggcgggcg gcagggcgag ggcgtgcacc acggcggccc ggacaacggc cggctcggcc
    15001 acggcgagca cgcggccggt gtcggcgggc agcgcgtcca gccagccgcc gacccgggcc
    15061 agcagcgcgc cgacggactc cccgccgggc ggggcgaaac cggggtcgga cagccaagcg
    15121 gcgatcgact ccggttcggc agccgcgagt tcggccagcg gacggccgcg ccaggcaccc
    15181 ggatccaggt cggcgagaca gggctcgtcc gccggcatca ggtccagcgc cccggcgctc
    15241 tgccggcagc gcggcgacgg ggccgacagc acccggtccg ccctgggcac ggccagcgtc
    15301 cgggccggag ccaggtcggc atccgtcagc ggcaggtcgt caccgaaccg ggcgccgcgg
    15361 ccctccgcgc cgagcgccgg tgcgaccaac atcacccgga ccgtcacagg cccaccctcc
    15421 caaagatcat ccgtccacga atcgtggatc ggagtgccgc gcccctggcg ggccgtgccg
    15481 gggaacggta ccttctcggc gaacaacccc atatcaacga cggtgcgtgg aagtccggtg
    15541 caagcccggc acggtcgcgc cactgtgaac ccctgaccag ggggaagtca gacccgcctc
    15601 cgtcgtttcc tgctccacac gaccgggacg cgagttcccg caaggaggtc acaccgccat
    15661 ggctcacccc atcgcgcccg ccgccgtcac cacgccggcc ctcacccccc tctccgtcaa
    15721 ggccatcgcc ccctgggcgg ccttcttcgg catcctgctg ctcaccctgc tctacttcgt
    15781 cggcgccgaa cagggcgcca cctcgctgct ctccggcgag agtgtgcacg agtgggtgca
    15841 cgacgggcgg cacctgctcg gcttcccctg ccactgaccc gctccggcag aagaagcgag
    15901 caactgaaca catgaactcc cacaccgtca ggaacctcct ggtccgcggc atgctcgccg
    15961 gcctcggcgc gggcgtcctc gccctgatcg tcgcctacct gctgggcgaa ccccgggtcg
    16021 acgcggcgat cgccttcgag gactcccaca gccacgagca cggcgaggaa ctggtcagcc
    16081 gcaccctgca gtccaccgcg ggcctggcca ccggcatcct gatctacggc ctcgcgctcg
    16141 gcggcatcgc cgccctcgcg tactgcttcg ccctcggccg caccggccgc ttcggccccc
    16201 gggccggcgc cctgctgctc tccggcgcgg cactggtcgc cgtctacctc gtcccgttcc
    16261 tcaagtaccc ggccaacccg ccgtcggtgg gcgacccgga gaccatcggc aagcgcacca
    16321 ccctgtactt cctgatgatg ctgctgagcg tgctgctcgc ggtcgccgcc gtggcggccg
    16381 gcaagcagct cgccccgcgc ctgggcaact ggaacgccac cctggccgcc gggctcggct
    16441 acgccgcgct gatcggcctc gggtacgtcc tgctgcccgc cgtcaacgaa gtccccgagg
    16501 acttctccgc ctccctgctc tggcagttcc gggttgcggc cctggccatc cagctcaccc
    16561 tgtggctgtc cttcgggctg ctcttcggcc acctcgccga acgcctgctg ctgcccaagc
    16621 cggcccgccc cgccaacgca gccgccgagg cgaccccggt cgccaactag cgactccgac
    16681 gggccggttc gcacctttca tgcggtgcgg accggcccgt cggcgttccc ggggccggag
    16741 ggcggggcgc ctactgggcg acgtcgggcg ctccgtcgtc cgccgcaccc gccccttcgg
    16801 cggcggccag gcgggacagc gcctccgcca gcgcgtgctg gagggcgcgt acccgcgcgg
    16861 tgcacccgcc gacctgacgc cggttcgcga gcagggcctc gtactcccgc tcggggagca
    16921 cgaccagcac ctcctcgccg atcctgatcc gctgcacttc gccccgtccg gccatcggcc
    16981 gcccccttcg atcgctccgg ccggtccggg cgggcgcgcg gcgtgcccgc ccggaccggt
    17041 gtcatgtcag tcgatccgcc ggttctgcaa ctccgcgcgc agggtgcggg cggcggcgac
    17101 caggctctcc accgaggccc gggtctcggg ccagccgcgg gtcttcaagc cgcagtcggg
    17161 gttcacccac agtcgctcgg cggggacggc ggtgagtgcg aggcgcagca gcaggacggt
    17221 ctcggcgggg gacgggacgc gcggcgagtg gatgtcccac acgcccgggc cgacctccgc
    17281 cgggtagccg gccgcggcca gctcgtgggc gacctgcatg tgcgagcggg ccgcctccag
    17341 cgagatgacg tccgcgtcca actcctcgat ggcgcgcagg atgtcgccga actcggcata
    17401 gcacatgtgg gtgtggatct gggtgtcggc gcggactgcg gcggtggtga ggcggaacgc
    17461 gtcggtggcc cagtccaggt aggcgggccg gcccgcgcgg cgcagcggca gcgtctcgcg
    17521 cagcgccggc tcgtccacct ggatcaccgc cgcgcccgcc gcctccaaat ccgcgacctc
    17581 gtcccgcagc gccagcgcga cctgccgggc ggtgtcggcg agcggctggt cgtcgcggac
    17641 gaacgaccag gccagcatgg tcaccgggcc ggtcagcatt cccttgaccg gacggtcggt
    17701 caggctctgc gcgtacgtgt accagtcgac ggtcatcggg tacgggcggg agatgtcgcc
    17761 ggcgagcacc ggcggccgca cgtagcgggt gccgtaggac tgcacccagc cgtgccgggt
    17821 ggtcaggtag ccggtgagct gttccgcgaa gtactgcacc atgtcgttgc gttcgggttc
    17881 gccgtgcacg aggacgtcca gcccggcctg ctcctggaag gcgatcacct cgcggacctc
    17941 gtcctccatc cgcttgcggt agtccgcctc ctccagtcgg cccgcgttca actcggcgcg
    18001 ggaggcgcgc agttcggcgg tctgcgggaa ggagccgatg gtggtggcgg gcagcggcgg
    18061 cagctgcaac cgggcgcgtt gggcctcggc gcggacggcg tacggggcgt cgcggcgggt
    18121 gtcggcggcg gtgacggccg cggcgcgggc ccggacggcc gggtcgcggg tgatcgggga
    18181 cgcggcgcgg gacgccaggt cggcgcggtt ggcggcgagt tgggcggtga tggcggagcg
    18241 tccctcgcgc agggcgcggg ccagcagcgc cgcctcggcg gccttctgcc gggcgaacgc
    18301 cagccagcgg ccgatctgcg ggtccaggtc gcgctcggcg gccacgtcga ggggcacgtg
    18361 cagcagcgag caggacgggg cgacgtccac ccggtcggcc aggccgagca gggtggcgag
    18421 ggtggcgagc gaggcgccca ggtcgttgat ccacacgttg cggccgtcca ccacgcccgc
    18481 gaccaggcgt ttcccgggca ggccgccgac cgcggctagg tcggcgaggt tgcccgcggc
    18541 cgggccggtg aagtccagcg ccaggccctc gaccggcgac ttggcgagca caggcagcgc
    18601 ctcgccgagc cggtcgaagt aggaggcgac cagcagcttc ggacggtccg tcagcgcgcc
    18661 gagatcccgg tacgcgcgag cggcggcgtt cagttcggcc ggcgtgcggt cctgtacgag
    18721 cgcgggctcg tccagctgca cccactcggc gccggcggcc cgcaggtcgg ccagcagttc
    18781 ggcgtacacg ggcagcagcc ggtcgagcag ggtgagtggt tcgaagccgt ccggcgcgcc
    18841 gggtgcgggc ttggcgagca gcaggtaggt gaccgggccg agcagtaccg gccgggcccg
    18901 gtggccctgg ccgagtgcct cgcggagttc gccgacctgc ttggcggagt ccggggcgaa
    18961 taccgtgtcc ggccccaact cgggtaccag gtagtggtag ttggtgtcga accacttggt
    19021 catctccagc ggcggcgtct gctgggtgcc acgcgccatg gcgaagtagc cgtccagcgg
    19081 atcggcctcg tacgcggccc ggtggcgggg cgggatcgcg ccgagggcga cggtggtgtc
    19141 gagcacgtgg tcgtacagcg agaagtcgcc ggtggggact tcggtgatgc cggcgcccac
    19201 cagttggcgc cagttggtgc agcgcagttc ggcggcggtg gcgagcagcg cgtcggcggt
    19261 gacggcgccc ttccagtagc cctcgatcgc cttcttcagc tcccggttcc cgccctggcg
    19321 ggggtagccg tggacggttg ccgcggctac ggacttcgta gtcaagggga ctctcctcgc
    19381 gagccttgat cctgggtccg gtgcacagga gggcgcgcgg ggtggcgaag accgggcggt
    19441 gcggcgctcg accgcgcctg cccgccgggt gtccgtgccg acccgccctc gaggtcaccg
    19501 gctaccgggt gcgaacggac gcatccgggc aacgggcagg tcttcggact cgcgggcaca
    19561 cccggggagt tgatcgatcc cgggcaccta ctggccgtcg cttcccaggc ccgtccggac
    19621 ccagtgcgta tgacggcggt cgttcccact caccgctgcg gggcagtccc ggattcccac
    19681 cgggttccct cttacgacgc cctgcctggc ggacagggcg aaccagttgc gcggtcagtc
    19741 tagaacgccc cgggcggctt ccggcgcaaa gtcggtgatg tgtccggtcc ctgggagggg
    19801 tcggcgcggc gcagcaggca ggtgtccgcg acccagccct tgccctcgcg cgccttctgc
    19861 ctcaacccgg cgatccggta ggcgagttca gccagtgggc cgggtacccg ggccggcgcc
    19921 gtgatggatg tgcccgccct cggggtcgat ctccgtgaac gcgacctgcc cgttcaccgg
    19981 cactgtacga ctgtgtgagc gccgagccgg accgggtcct ggtgccgcgg gcagcgtgct
    20041 gggtgatcat ctccggccgc ggccgcatca ggtcccgccg cccggccgtc accgcggaga
    20101 acgtcaacgc cgcgtggacg ggcacggtgg cgcccgagcc caccaggacc gacgaggtca
    20161 gccggtgaac tcctggatca acctggacgc gatctggcgg atcgtcgtgg tcggcctgct
    20221 caccggcgcc ggcctgcccg ccctgttcgc cctcggcctg cgcctgctca acccggcgcc
    20281 cctccccggc cggccggcca ccgaccgccc caccgccgga ccgctcggcc gcaccctggc
    20341 cgggctgatc ttcgccgtgg tgctcgccac gatcggctgg ggcgtctccg gcatcgtcaa
    20401 ccaccggtga ccggtcgccg gcaacggcag caggatggag gccttgcccg gcgaacacgg
    20461 ccgtctgccc ttcgccggcg acacctcggc cagcaccgtg tgcgcagggg tggatcaccc
    20521 cgccgggagc gggcggttcc tgccggaggc ggctgcgtgg gcgattcgcg gtccgtaggg
    20581 ttgtcccgaa cgggccgagc ggagtggctt cccggcccgg agggcaggag gtggtcgcgg
    20641 tgcagttcca acccgtcctt gtcactggtg tcggcgggcg cgtcggcggg gtcggacgag
    20701 cggtcgtcga ccggttgcgt gccgagggcg tgccggtccg ggcgctcgtg caccacgacg
    20761 acgagcgggc ctcggcgctg agggccgtgg acggcgtcga ggtggtggtc ggtgacctca
    20821 ctcgcggggc cgacgtggcc gaggcgctgg cgggctgccg gcgggcctac ttcgggatgg
    20881 gcgtgtcgcc cgcgtacctg gaggcggcga cgacggtggc cgcggccgcg cgggagagcg
    20941 ggggtttcga tctgctggtg agcatctcgc agatgacggt ctcgcagatg gacctcacca
    21001 gccgtgcgga gtcccggcag cagcggctgc actggctgac cgagcacgtc ctcgactggt
    21061 cgggggtccc ggtcgtccac gtccggccca ccgtgttcat ggagaatccg ctgttcgcgc
    21121 ggatcgccct cgcgtcgatc ctccgcgacc gcacgatccg tctgccgttc gggtccgcgc
    21181 ggacctcgcc ggtcgccgca gccgatgtgg cggaggtcgt cgcacggctg ctgctcgatt
    21241 cagctccgcc gtcccgccgc gtctacgaac tgaccggagc gcgctcgcgt gacatgagcg
    21301 tcatcgcggc cgagttctcc gccgccttgg gccgggccat cacgtacgtc gacgtgccgt
    21361 acgaggagtg gttggaccgc gacctcagga cgcaggacct gccgccccac gtcttcgagc
    21421 acatcgccac gatggcgcgg ctgcacggcg agaaccggta cgaccgggcc acgaacgacg
    21481 ttgccgaact cctcggacgc cccccgctgg ggttcgacca cttcatcagg aacacccccg
    21541 gcctgcggcc gtagccgact ccgtcgctcc tgccgtggtc cgccggggtc ctcagttgtc
    21601 agcgggagga gagaccttgc ctcccgaaga tccttcagtt cctcgcggac cagccggacg
    21661 atctggccct cctgcggtcc tcgggccttg tcgttgccgc ctacgagggc ccgggcgcgg
    21721 gggtcgacgc ccagttcagt ctgtgtcgct cggggcagtc acctcggccg gagctggcga
    21781 ggcgccaggt ggcgagcttg ccccaccggg accctgactc ttttcacagg gagtccacga
    21841 gcccgccgtc gatgacgaag tcggcacccg tgatgttcgc ggcgcctggg ccggcgagga
    21901 acaggacgag gtccgcgacc tccgccgggc gggtgaagcg gccggtcgcg gactgggccg
    21961 cggcagcgcg ggccacgtcg tcggggccgg taccacggga tcgaccgacc gtggcggcga
    22021 cgccatcggt gccctgccac agcgcggtct ccaccgggcc ggggccgatc gtgttcaccc
    22081 gcaccccctg tggtcccacc tccttggaca gggccttgca gaagttggtc agtgcagcct
    22141 tggcggcacc gtagtcgatg accagggggt ccggcagccg ggcgttgacc gaggagacgg
    22201 tgacgatgcg tcccgcgccg gaggcgagca ggtgcggcag ggcagccctg gtggtgcgga
    22261 cggcggtcag gaggttgacg ctcagggccc agtcccagtc ctcgtccgtc acgctcagga
    22321 aaccgtccac cctcgggcgc accgctccga cgttgttcac cagcacgtcg atgccgccat
    22381 ggagccgggc ggcctcggtg atcagcccgg ccggaccgcc cggtgtcgcg agatcgactt
    22441 ccacgacggt gaggttcgcg ccctgctcca cgtgcgtgtc gagggcctcg gtgcgtgtcc
    22501 gtgatcccgc gacgacgtgg catcccgctg cgaggaacgc ctcggtgatc gcgagcccga
    22561 tgccacgccc ggccccggtg acgacgacgg tctggccggt cagaccgtcg tcgtcaccgg
    22621 gcctcgccga tcgcgacggt gtggaagggg tcaccgcgag gtctccacgg tcggtcgtgc
    22681 cggcccgccg aacgcggtgt ccgccgagct gctgtgcggt cggcgtccgt gaacgaggac
    22741 gacggcgatc gaggttgtca cggctggagc ctctctgagc gtgcgcgcgc gggtgccctg
    22801 acccggtatg tccgtatcag
//
