LOCUS       NZ_PCGR01000002        20804 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Chryseomicrobium excrementi strain ET03 Scaffold_2, whole genome
            shotgun sequence.
ACCESSION   NZ_PCGR01000002
VERSION     NZ_PCGR01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Chryseomicrobium excrementi
  ORGANISM  Chryseomicrobium excrementi
            Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae;
            Chryseomicrobium.
REFERENCE   1  (bases 1 to 894072)
  AUTHORS   Chakraborty,R. and Saha,T.
  TITLE     Draft genome of Chryseomicrobium casticus sp. nov.
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 894072)
  AUTHORS   Chakraborty,R. and Saha,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-OCT-2017) Biotechnology and Zoology, University of
            North Bengal, Raja Rammohunpur, Siliguri, West Bengal 734013, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 28-AUG-2017
            Assembly Method                   :: SPAdes v. 3.11
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 3.0x
            Sequencing Technology             :: Illumina NextSeq 500
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002798305.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 02:44:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,745
            CDSs (total)                      :: 2,682
            Genes (coding)                    :: 2,659
            CDSs (with protein)               :: 2,659
            Genes (RNA)                       :: 63
            rRNAs                             :: 7, 4, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 1 (5S, 23S)
            partial rRNAs                     :: 2, 4 (5S, 16S)
            tRNAs                             :: 47
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 23
            CDSs (without protein)            :: 23
            Pseudo Genes (ambiguous residues) :: 0 of 23
            Pseudo Genes (frameshifted)       :: 6 of 23
            Pseudo Genes (incomplete)         :: 12 of 23
            Pseudo Genes (internal stop)      :: 6 of 23
            Pseudo Genes (multiple problems)  :: 1 of 23
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:08:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 17070
            Orig. end                         :: 37874
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            PCGR01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20804
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20804
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20804
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10804](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10804
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(766..779)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.41"
                     /tool="antismash"
     misc_feature    complement(1548..1561)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.65"
                     /tool="antismash"
     gene            complement(1677..2111)
                     /locus_tag="CQS04_RS04650"
                     /old_locus_tag="CQS04_04655"
     CDS             complement(1677..2111)
                     /EC_number="5.2.1.8"
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /GO_process="GO:0000413 - protein peptidyl-prolyl
                     isomerization [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_390217.1"
                     /locus_tag="CQS04_RS04650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQS04_04655"
                     /product="peptidylprolyl isomerase"
                     /protein_id="WP_100353022.1"
                     /transl_table=11
                     /translation="MAKTGYFLMESGDKLEFELFPNEAPNTVANFEQLANSGFYDGVIF
                     HRVIPGFVSQGGDPTGTGMGGSGKTIKCETDGNPHKHEPGSLSMAHAGRDTGSSQFFIV
                     HESQPHLDGVHTVFGKLTSGLEAARSMSNGDKMKEVRVNG"
     gene            2197..3294
                     /locus_tag="CQS04_RS04655"
                     /old_locus_tag="CQS04_04660"
     CDS             2197..3294
                     /GO_function="GO:0004180 - carboxypeptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244: amidohydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012292590.1"
                     /locus_tag="CQS04_RS04655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQS04_04660"
                     /product="amidohydrolase"
                     /protein_id="WP_100353023.1"
                     /transl_table=11
                     /translation="MSREQQILEWYQHFHTNAEVSWNEIKTTNKLAQIMDELNVSYRTF
                     EDVTGLVAEIGEGEEVIAIRADIDALWQEVGGVFQANHSCGHDANMAMVLGALLEVKDE
                     AFSKTIRFIFQPAEEKGNGANSMIDRGAVEGVTHLFGVHLRPAEELEYGKYSPAIHHGA
                     AMFLQGKIHGVDAHGARPHQGKNSIDVVFSIHQMLKNLYFSPFDSYSVKLTNIHAGGDS
                     LNIIPGQASFAIDARAQKNDVLTEIKEQVERKLRAIGQQFDVTIEWEWQDMTPGAEVSA
                     EAAELARQGILNEVGDSVLEPEIHTSGSDDFHFYTIRRPEIKAAMIGVGAGMTHGLHHP
                     EMSFDTSILPQASRVLASVLRKAAK"
     gene            3406..4818
                     /gene="nhaC"
                     /locus_tag="CQS04_RS04660"
                     /old_locus_tag="CQS04_04665"
     CDS             3406..4818
                     /GO_function="GO:0015385 - sodium:proton antiporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="nhaC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019240883.1"
                     /locus_tag="CQS04_RS04660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQS04_04665"
                     /product="Na+/H+ antiporter NhaC"
                     /protein_id="WP_100353024.1"
                     /transl_table=11
                     /translation="MEKPKIEKKEMALGWAVLPLVLMILVMFYTIVELEQGPHIPLIIG
                     TSIAAIVAWKHGFKWAEIEEMMYKGIRLALPAVVIIILVGLTIGAWIGSGVVATMIFYG
                     LKIISPAFFLVTITLICAVVSLAIGSSWSTMGTIGVAGMGIGLSMGIPAPMIAGAVISG
                     AYFGDKMSPLSDTTNLASGLTGTDLFVHIRHMLYTTIPGIIIALAVYWVLGQNYANGAI
                     DQQAINQTIIELNQQFDISAWLLLIPLAVIVLVALKVPAIPALVVGIVLGVLAQIFVQG
                     GSLADAVSALQAGYVIDSGNALVDDLFNRGGLDSMMYTVSMTIVAMTFGGILEYSGMLQ
                     SMMNHILRLAKSAGSLVATTIAAAITTNATCSEQYISIVVPARMFAESYEKMGLDSRNL
                     SRALEDGGTLTSVFFPWNTCGVFILGTLGVGAFEYAPYAVLNFVVPLLSIVYAFTGFTI
                     LKVRQQTALQNA"
     gene            complement(4856..6085)
                     /locus_tag="CQS04_RS04665"
                     /old_locus_tag="CQS04_04670"
     CDS             complement(4856..6085)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CQS04_RS04665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CQS04_04670"
                     /product="hypothetical protein"
                     /protein_id="WP_100353025.1"
                     /transl_table=11
                     /translation="MALTIAVVSSELFAPRIRELASEFSDIHFIYYTYKHSTEARTIAS
                     DLPNVDAVFFAGTFPYYHAKSILDERQLPVYVMRQDEAVVTATLLQAGWLHQVAPQDIS
                     IDLTDPVLIHEIVTEISPGHTIGAVLQIDPNISQQAVVQFHSYAQQSGRVRVAITSIHA
                     VHEELIQKGYRSVYMRELKRTLVRALAQTAYLARLSKSQKAEPAVMLISKSHADPTFHA
                     TIRRHVQGSWFPYNEDTDQFITTRKHVEFVMEQSEFREFLETSRARTGIGYGLDILTAT
                     RHAEDALDFSSEGGIYIMDAQKNLSSPMSSERITLQLTQPNQVLLAKRMGLSPANLSKL
                     ISFYAIHPSNQFTAQDLENFLGVTRRSTERIIKKCVDHKLVVATGEEMTYQQGRPRTIY
                     TFTLPDFLTV"
     gene            6169..7290
                     /locus_tag="CQS04_RS04670"
                     /old_locus_tag="CQS04_04675"
     CDS             6169..7290
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1268: mandelate racemase/muconate lactonizing enzyme"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010287289.1"
                     /locus_tag="CQS04_RS04670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQS04_04675"
                     /product="dipeptide epimerase"
                     /protein_id="WP_100353026.1"
                     /transl_table=11
                     /translation="MKITQIDLYAIRLPLITPFVVSYHSYADMPSLIVKITTDEGIVGY
                     GEAVADDHVTGESWESTFALIEHSLAPALIGHNPMHFEALHDLMDSIVYQAPAAKAALD
                     IACFDAVGKKLGVPVYDLIGGRYHERFPITHVLSIGEPAAMAEEARERMEQGYSSFKMK
                     VGRDVLSDVARIRAVREAVGDDIAIRVDVNQGWVNASSTLQAIELMKGLNIDWLEQPVK
                     ADDIEGMVEIKAKSTIPLMIDEGMKSKREMRQVIQQGAAHKVNIKLMKCGGIYPAVKLA
                     HMAEMAGLDCQIGSMVESSVGSAAGFHVAFAKKVFSSVELTGPLKFSKDIGNLHYDVPF
                     IALNDQAGLGVDVDERVLEELTVRRTTIGQEGA"
     gene            7290..7952
                     /locus_tag="CQS04_RS04675"
                     /old_locus_tag="CQS04_04680"
     CDS             7290..7952
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CQS04_RS04675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CQS04_04680"
                     /product="N-acetyltransferase"
                     /protein_id="WP_100353027.1"
                     /transl_table=11
                     /translation="MSFPKDGFRMTLLNLQHLEAIERLQDRVAAHLERVDQLQKLTHDE
                     IRIILHQELFAGVWIDDQLVAARAFLYTPEDEEHLAKDVGIHVDEWKDVIYSEISLVDP
                     SYQGHGLQKKMGAWWMERLQTSPYRYVCATVAPFNIPSMKDKFQLGMSIGALKVKYGGK
                     LRYIFVRDLQQTREVTELQAVPMADTEMQQQLLARGARGVGLLEQDGAWLVQYTIVD"
     gene            8025..9905
                     /locus_tag="CQS04_RS04680"
                     /old_locus_tag="CQS04_04685"
     CDS             8025..9905
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012772.4"
                     /locus_tag="CQS04_RS04680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQS04_04685"
                     /product="GGDEF domain-containing phosphodiesterase"
                     /protein_id="WP_100353028.1"
                     /transl_table=11
                     /translation="MTIKTSMLVFGLVLSVAAFFYAFFWANVDPYHIVIDVIGAGAIGV
                     LVGWLVASRRKLTDERRLSIEEVETKRKELEDIQRELDALYFNSSAWIWSIDLEREKLK
                     VSTGILELFGYSQQEIEDDYQIWLTKALESDKYIAERHLEKLLRGERSEAEWRLYKKDR
                     SIAHIRSIGEPIRNDEGKVTRIVGVTFDFSKEIELQETMSRIAMTDTLTQLPNQVYFNR
                     QLEVRIEESEEDEQLALIYFNVDRLKFINDMLGFETGDEILQLIAERMPMYFGHDTLMA
                     RYGGDEFIIAYPHHDREAMQMKINQFMESFHTPFHTAEDELFVSVSIGVALYPDDAESV
                     NSLLSKANAALKRAKRKGKNNIQFYIRENEELQKRKLRIEHDLKRALEFQEFELYYQAK
                     VSLMSHSVQGAEALIRWHHPILGEISPAEFIPIAEESGQIVPIGDWVLKQAIHQVKLWE
                     EVGTPLRVAVNVSSAQLEVTDFMDRLQLLLLESGITPNLLGIELTEGMVQNVEAAVPIL
                     FEMRQLGVSIYIDDFGTGYSSLGILNQLPIDFIKIDKSFIQEIPHNKGQATLVKTIIEM
                     GRNLGFELVAEGVEREEQAEFLLQNGCTKGQGFYFSHPLPVAEFEQRYLR"
     gene            10001..10804
                     /locus_tag="CQS04_RS04685"
                     /old_locus_tag="CQS04_04690"
     CDS             10001..10804
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019468496.1"
                     /locus_tag="CQS04_RS04685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQS04_04690"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_100353802.1"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.5e-30,
                     bitscore: 102.2, seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="phytoene_synt (E-value: 1.2e-14, bitscore:
                     49.9, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLKETSRTFYIPITFLQRDLKKAVASAYLCMRAIDEIEDHEDI
                     PKELKADILLKTASLLESSFDEEAYLRALEPIQHLMPEVTIRLADWVAYCPEGARKRMQ
                     LATAEMAEGMAKWALKEWKVETQEDLDDYTYYVAGLVGVMLSDMWEWDSGIRTDRDLAI
                     GYGRGLQAVNILRNQEEDSERGVGYFPKQWTRADMFAYAEANLAKADAYMEDISKRSIR
                     LFCQLPLTFAHKTMDAMKHGREKMTRAEVERTVQEVAGSDWEERA"
     gene            10801..11007
                     /locus_tag="CQS04_RS04690"
                     /old_locus_tag="CQS04_04695"
     CDS             10801..11007
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CQS04_RS04690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CQS04_04695"
                     /product="hypothetical protein"
                     /protein_id="WP_100353029.1"
                     /transl_table=11
                     /translation="MKKLKWLLPIMVISAFFSVLILRDHPDVTFQNKVLITIGASLVSA
                     LIGFILLRQDIDKVDPKPKEKLK"
     gene            11004..12083
                     /locus_tag="CQS04_RS04695"
                     /old_locus_tag="CQS04_04700"
     CDS             11004..12083
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:1905887 - autoinducer AI-2 transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008405857.1"
                     /locus_tag="CQS04_RS04695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQS04_04700"
                     /product="AI-2E family transporter"
                     /protein_id="WP_100353030.1"
                     /transl_table=11
                     /translation="MTKKLWFQVGVAILLTLVIIRMVVEVQAIFNPFFVILRTVFLPLL
                     IGGVLFYLTRPLVKLLERKKVPRWGSISIVVILLLAVIVGFTSIVGPVLTNQVNALVKN
                     GPVIIKEIESMTDYVLDQRDRLPESMQDSIQDAVGRANEFAVSGGTLLINFFQGLFQGI
                     FMLVLVPFFLIYMLKDHEKLAPFVAKFFKGERKTWIRKTLADIDETLKTYIQGQLLVSF
                     LVGVMLLIGYMIIGLKYPLLLALFGMLTNVIPFLGPYLAVIPAMIIAFTQEPIMALWVA
                     LVMLVAQQIESNLITPNVMGKSLDIHPLTVITIILSAGSLAGLWGIILAIPAYAVVKSI
                     LRNIYAYREEIRDTANKDV"
     gene            complement(12142..12552)
                     /locus_tag="CQS04_RS04700"
                     /old_locus_tag="CQS04_04705"
     CDS             complement(12142..12552)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015881002.1"
                     /locus_tag="CQS04_RS04700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQS04_04705"
                     /product="VOC family protein"
                     /protein_id="WP_100353031.1"
                     /transl_table=11
                     /translation="MPVIAYLNFNGNTEEVVRFYHEVFATEAPHIQYFKDMPGHEADPE
                     LGNRVLHARITVHGSPLFFSDSMPQNPVTHGDGITLAIVGDDADLLTQQFNLLAEKGRV
                     LMPIQETFWSKAYGIVQDQYGIQWQFSHEVSA"
     gene            complement(12564..13238)
                     /locus_tag="CQS04_RS04705"
                     /old_locus_tag="CQS04_04710"
     CDS             complement(12564..13238)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CQS04_RS04705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CQS04_04710"
                     /product="hypothetical protein"
                     /protein_id="WP_100353032.1"
                     /transl_table=11
                     /translation="MLTTSQRQQLTQYSVYLQPAGPVLFHTGEWKEHLTTVQEIIQAPH
                     KTAAASYLTRRLGLFLSMQFWNLTLYDERWVGDPNNLQWVLVREYGNPAISAFVQEEHY
                     VPLQNETERPHAVQAIWNLADTVVTSLSTSPAIQQIHWENIFGYTVWHYSVFLQQADLW
                     EKALTDWMLLQNPDLGEGAAKFSNFVAGRSALDLTRVPVRSTCCLAKDIAGQLKCGFCP
                     ID"
     misc_feature    13283..13298
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 25.54"
                     /tool="antismash"
     misc_feature    13283..13301
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.61"
                     /tool="antismash"
     misc_feature    complement(13285..13299)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: strong, score: 26.44"
                     /tool="antismash"
     misc_feature    complement(13286..13301)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: strong, score: 27.81"
                     /tool="antismash"
     misc_feature    13289..13304
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 23.31"
                     /tool="antismash"
     gene            complement(13416..16445)
                     /locus_tag="CQS04_RS04710"
                     /old_locus_tag="CQS04_04715"
     CDS             complement(13416..16445)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1049:
                     AcrB/AcrD/AcrF family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012574413.1"
                     /locus_tag="CQS04_RS04710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQS04_04715"
                     /product="efflux RND transporter permease subunit"
                     /protein_id="WP_100353033.1"
                     /transl_table=11
                     /translation="MSWITRFSLRNAVAVFIFAFLLILLGLFSFSRLKIDLLPNIEFPQ
                     LSAQIVYPGASPDDVNEQVITPLEQAFEGLEGVQEIQSASYDTIGVINLVFPFDTDLDR
                     LEQQADTAIAEAGLPEEATVEISRLSFGAFPIFNISLFAEEGVDLDELLDTDVIPELSK
                     IPGVNSVSVGGLTDTELQITVDQAAAEQAGLTLGQIKDQIDQKFFSFPAGQVQQNDITI
                     PVKVEQVLESIDDLESLSLQNSFNPSAPPVTLGDIATIEEVETQDEITRYNDEEAYSMA
                     VTKKQDANTVEVADEVLEVLEKYDGELSYSIGFNSAEGIEKSVETLVKEGLLGALFASI
                     AVLIFLRNWRATIIAIISIPLSLLIAAIFLNQLGITLNIMTLGGMAVAVGRVVDDSIVV
                     IENIFRRLRKPGVEMTNEMVETSTKEILKAITSSTITTVVVFLPLGFVSGITGEFFLPF
                     ALTVVFSLLASLLVAITIVPILAKFSFKKIKQEEKEDVLQRQYGRAIAWSLRRKWLVLL
                     ISLVLLGASFAIVPRLGFTFIPDEESRLVQASIELPSSTTLDRTNEVSLEVEQLLLGYD
                     EVDSVTTSVGARDFATGIKLVNRAGYFISLNDDADLDAFLDKAATDMDELVTSINDQTT
                     VSVSEVSTGGPPTNNNVVVDLFSTNLDDLEQAAAEVEALLSERDDLKYVSNNFSEKQEQ
                     LVVTVNTEAADARGISGFQILGAISDQTRPVELGELQIGEDRPSVQLSYDEGVTSPEEI
                     EELTLFTTQGPVTLSEVADVEQIESFTSIQKLDGRVFARVEAQVNAENIRAVSTDVLAA
                     VESDIDLPESVSLEGGGGSDETVEVFQQLGIAILSAIGLVYLTLLITFGKARIPFVILS
                     SLLFVPIGALFGLLIAQEPLSVSVMIGFLMLIGIVTTNAIVMVDRINQNRYDKGMPIRE
                     ALVEAGKTRLRPILMTAFATIAALIPLALTTSSGTLISKGLAITVIGGLTSSTLLTLII
                     VPVIYEFFFFRDVRRETKKA"
     gene            complement(16459..17013)
                     /locus_tag="CQS04_RS04715"
                     /old_locus_tag="CQS04_04720"
     CDS             complement(16459..17013)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="CQS04_RS04715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQS04_04720"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_100353034.1"
                     /transl_table=11
                     /translation="MTEQELRSRILFAALETFGKEGFFEAKMLTIARLAKISKSTLYAM
                     FPSKEELYTDMMKFTFSMYLTTIERHIQNQRTFPETLQAISQEHLQNIWKQRHRSGMYL
                     QLNHKHEEAMDALMDFIEAYIELIRQFFEQHGIENAATKARLYVGMLDSFRNEIFMDPS
                     FNEERLTEIRQQIDQIVITGF"
     gene            complement(17100..18056)
                     /locus_tag="CQS04_RS04720"
                     /old_locus_tag="CQS04_04725"
     CDS             complement(17100..18056)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004229766.1"
                     /locus_tag="CQS04_RS04720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQS04_04725"
                     /product="multidrug resistance efflux transporter family
                     protein"
                     /protein_id="WP_100353035.1"
                     /transl_table=11
                     /translation="MKAIGLGIVAALFFAVTFVLNHAMELSGGSWMWGASLRYFFMVPF
                     LVIIVWMRGGLPPLARDMRTSPGPWFIWSFVGFVLFYAPLTYAAAFGPGWLVAGMWQLT
                     IVAGILLAPLFLSNDGNREVIPRAALVISGVILVGIFLLHLPQAASVPLATLLLGSLPV
                     VVAAFAYPLGNRKMMQHVGSRLDSYQRVLGMTIASLPAWILLAAYAWMTVGLPSGSQVL
                     QSFFVGVSSGVIATVLFFMATDMARHSQSRLASVEATQSTEILFVVAGEMVLLQLPLPA
                     PIALAGMGIIVLGLLAHSLHTIWEQKQKLHTTSNHVS"
     gene            complement(18075..19298)
                     /gene="pepT"
                     /locus_tag="CQS04_RS04725"
                     /old_locus_tag="CQS04_04730"
     CDS             complement(18075..19298)
                     /EC_number="3.4.11.4"
                     /GO_function="GO:0045148 - tripeptide aminopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="pepT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006830885.1"
                     /locus_tag="CQS04_RS04725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQS04_04730"
                     /product="peptidase T"
                     /protein_id="WP_100353036.1"
                     /transl_table=11
                     /translation="MKQTLIERLTRYAKIDTQSDAASTSTPSTEGQWDLLRLLEQELQT
                     MGMTEITLDDNGYLFATLPATTEKDVPTIGFLAHVDTATDYTGKDVNPQIVENYDGKDL
                     VLNATTTMKVSDFPELPKYKGHTLMTTDGTTLLGADNKAGIAIILTAMDYFLKHPEIEH
                     GKIRVGFTPDEEIGRGPHKFDVAAFGADYTYTMDGGPLGELQYESFNAAGARVTTHGVS
                     VHPGSAKDKMVNAITMAMKFQSHMPPQEVPEKTEGYEGFVHLMDIHGKVEKTVMDYIIR
                     DFDKAKFEEKKQRFHDAASAIRAQYGDDAIEVELNDQYYNMGEKITPVMEIVDHVKAIM
                     EDLEIEPLIIPIRGGTDGSQLSYMGMPTPNIFTGGENYHGKFEYISIENMEKATQVVQE
                     IIKRAALK"
     gene            complement(19318..20157)
                     /locus_tag="CQS04_RS04730"
                     /old_locus_tag="CQS04_04735"
     CDS             complement(19318..20157)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019395623.1"
                     /locus_tag="CQS04_RS04730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQS04_04735"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_100353037.1"
                     /transl_table=11
                     /translation="MTPNQELYEYLQKHTWDLTEEWYAALDKESTSGVYASNDATVIET
                     IKQQNHGFHERFCKVFVQDEATFLKEFEAWVLEIARDPEHLNTPLHFILQEFFNTQQQY
                     IHLLYRYERQASDLTHETVQEWIATVTKTFSKLMTWFTEEHHNYSLKKLRAQQEMINEL
                     STPVISLSNGVALLPLVGDIDTNRAKHIFENALTQCTQKRVQSLLIDISGVAIIDTMVA
                     QQIFQLIEALRLLGVESTLSGIRPEIAQTAVQLGISFQDVNTISTIERAVQRLFTEK"
ORIGIN
        1 agcgtcggga agtttatgat gtgttagaaa gtatgacgga tgctttttac gcactcgatc
       61 cggaatggcg atttgtttat ttaaatgacc aagcagctac gctcttacga cgctcaaaag
      121 aagacttgat tggaaaaaat atgtgggaag tctttccgga agcgaagaaa accgctattt
      181 acccggctta tctcgctgtc ttgaagtctg agcaaagtcg tgtaatggaa caattttatc
      241 cacctcttga agcgtggttt gaaatacata tttatcctcg tggatcaggt ggcatctcgg
      301 tgtactttaa agacgtaaca gacaagaagc aaaaagaatt caagctttgg gaaacggcac
      361 attttgacca tttgacggga ctgccgaatc gaatgcatct ctataaagaa cttactgcca
      421 aaattaagga acaacagaag ttgggcattt ttttcttgga tttaaatgac ttcaaaatga
      481 tcaatgacgt ttacggtcat gataagggag atgaattgct ccagcaagta gcttctcgat
      541 taaaaactca gctaggacct gagtttttta tcagtagatt tggaggagat gagttcgtca
      601 ttaaaacaga ctatctcgat gaagaacagc tggatcaaga agccgagcgt attgccagct
      661 gttttcatga tgctttctgg ttacaaggag tgaacggctt ccatgtgaca gcatctatcg
      721 ggattgctct ctatcctcaa gatgcgacga gtgtagacga cttgattact aagagtgaca
      781 tggccatgta cgaagcaaaa aaaattaagc agacccactg gatgtactac tctacatcca
      841 tggcggagag ctggaatcgc cggttacgac ttgagaaaga gttgttacct gccctacaag
      901 cggggcactt gttgccgcat tatcaaccgg agctcgacac tgtggtccag caagtggtga
      961 gcttggaggt gcttgcaaga tggttccatc cgacgctcgg attcatctct ccccaagagt
     1021 tcattccgat tgcagaagag tcggctcagc tacaagccct aacagaagga ctgattcaac
     1081 acgctctaaa ggatttcatc tactggcagc accactgtgg gtatcgaggt atgctctcta
     1141 ttaacgtcac ttcacagctt gtctccgaag attctttttg tgaatttcta gtaaaaatca
     1201 agaaagagtg cggagttgca gacgggcttt tagagttaga gttgacggaa aacatgcagc
     1261 tcttcgaatc cccttttatt caacaaaagc tacgtctcct gcaagaaaat ggattccgta
     1321 tcgcgattga tgattttggg agcggttact ccaatttttc ttatattagt gagtttccga
     1381 tcgataaaat taaaatcgat aaatcgttta ttgactatat tggagaatca gaaaaaggag
     1441 aagccgtctt ggactctctt gtcctcctca gcttacgact gggcattgat ttagtagctg
     1501 aaggtgtaga gacggaagcg caagttcact atttgcagct tcgagaatgc atgctgatgc
     1561 aaggctatta tttttctaaa cctataccag cagaagaagc gacgactttc ttacaacgcc
     1621 tgcttgtaaa tgaataaaac cagttcaggc tgctgcccga actggttttt tgtggtttaa
     1681 ccgtttacac gaacttcttt cattttgtcg ccattagaca tactgcgagc tgcttctaaa
     1741 ccagaagtca atttcccgaa tacagtatga acgccatcta aatgtggttg agactcgtga
     1801 acgatgaaga actggctaga gcctgtgtca cgaccagcat gtgccatgga aaggctacct
     1861 ggctcgtgtt tgtgtggatt gccgtccgtc tcacatttga ttgttttgcc gctgccaccc
     1921 atacctgtac cagttgggtc gccaccttga gaaacgaatc ctggaatgac acggtggaaa
     1981 attacgccgt cataaaaacc agagttagca agctgttcaa agtttgctac tgtgttcggt
     2041 gcttcatttg gaaaaagttc gaattctagc ttgtcgccag actccattaa aaagtaacct
     2101 gttttcgcca ttgaaaagtc ctccatttca aattatcatc agtactagta tagcatggaa
     2161 cgcgagcgat acaaaaacga gacacggggg aagacgatga gcagagaaca gcagatctta
     2221 gagtggtacc aacattttca tacaaatgca gaagtgagct ggaacgagat caagacgacc
     2281 aacaagttgg ctcagatcat ggacgagttg aacgtgagct accgcacgtt tgaggacgtg
     2341 acaggacttg tcgctgaaat cggtgaaggt gaagaggtca ttgccattcg tgcagacatc
     2401 gatgccttgt ggcaagaagt gggcggtgtg tttcaagcca atcactcctg cggacacgat
     2461 gccaatatgg ccatggtgtt aggagccctt ctagaagtga aagacgaagc gttttcgaag
     2521 acgatccggt ttatcttcca gccagcggaa gaaaaaggca acggtgctaa ctccatgatt
     2581 gaccgaggag cagtagaagg cgtgacgcat ctatttggtg tgcatctgcg accggcagaa
     2641 gaactcgagt atggaaagta ttcgccagcc attcatcacg gagcagcgat gtttttacaa
     2701 gggaagattc atggagtaga tgcacacggc gctcgccctc atcaaggaaa gaacagcatt
     2761 gatgtcgtgt tctctatcca ccagatgcta aaaaaccttt acttttcgcc gtttgactcc
     2821 tattctgtca aattgacgaa cattcatgcc ggaggagaca gcttgaacat cattcccggg
     2881 caagcatcgt ttgctatcga tgctcgtgct cagaaaaatg acgtgctgac agagatcaaa
     2941 gaacaagtcg agcggaagtt gcgtgccata ggtcagcagt ttgacgttac catcgagtgg
     3001 gaatggcagg acatgacacc aggagcagaa gtttcggcgg aagcggctga gctggcgcgt
     3061 cagggtatct tgaatgaagt aggcgattct gtactagagc cggaaatcca tacatccggg
     3121 agtgacgatt tccactttta cacgattcgt cgtccagaaa tcaaggcggc catgattggg
     3181 gttggagcag ggatgacgca cgggttgcac catccggaga tgtcgtttga tacgtccatc
     3241 ttaccgcagg cttcacgtgt attagctagc gttttacgga aagcagcgaa ataagataag
     3301 agacatcgtc cacaaaacga tgtcttattt tttatattga caaaattctg tcacacttat
     3361 atgattactc cattaacgac atattaacga caaaggggtg ttcgtatgga gaaaccgaaa
     3421 attgagaaaa aagagatggc actggggtgg gcggtattac cactagtact gatgattctc
     3481 gtaatgtttt acacgatcgt ggaactcgaa caaggtccac atattccgct gattattgga
     3541 acgtcaattg cagcaatcgt tgcttggaaa cacggattca aatgggcaga aattgaagag
     3601 atgatgtata aaggcattcg cttggcgctt cctgctgttg tcatcattat tttggtaggg
     3661 cttacaattg gagcgtggat cggaagtggt gttgtagcta ctatgatttt ctacggacta
     3721 aaaattattt ctccagcctt tttcttagta acgatcacat tgatctgtgc ggtcgtatct
     3781 ctcgctatcg gaagctcttg gtcaactatg ggaacgatcg gtgtcgctgg tatgggtatt
     3841 ggactcagca tgggaattcc ggctccgatg attgcagggg ctgtcatctc aggagcttac
     3901 tttggagata agatgtcacc actgtctgat acgacaaact tggcgtctgg cttaacggga
     3961 acggatttat ttgtacatat tcgtcacatg ctttatacaa caattccagg gattatcatt
     4021 gcacttgctg tgtactgggt gctgggtcaa aactacgcaa atggagccat tgatcaacaa
     4081 gccatcaatc aaacaatcat tgagttgaac caacaatttg atatttcggc ttggctttta
     4141 ctgattcctc ttgctgtcat tgtcttggtt gctttaaaag tacctgcgat tccagcttta
     4201 gtagtaggga ttgttcttgg ggtactggct caaatctttg ttcaaggtgg ttctttagca
     4261 gatgcagtgt ctgcgctaca agctggatac gttatcgatt cgggaaatgc tctggtggac
     4321 gacttgttca accgtggtgg cttggattcg atgatgtata ctgtttcgat gaccattgtt
     4381 gccatgactt tcggaggaat tttagagtac tctggaatgc tacagtcaat gatgaaccat
     4441 attttacgcc tagctaagtc agcgggctct ttggttgcta caactattgc ggcagctatc
     4501 acaacaaatg caacttgttc tgaacaatat atttctatag tggtacctgc tcgtatgttt
     4561 gctgaaagct atgagaagat ggggcttgat tcacgcaatc tgtctcgtgc acttgaagac
     4621 ggagggacgc tcacatctgt gttcttccca tggaatacat gtggagtgtt cattttaggt
     4681 acacttggag taggtgcatt tgagtatgcc ccgtacgctg tactcaactt cgtggttcca
     4741 ttactgtcga ttgtctatgc gttcactgga tttacgattc taaaagtacg tcagcaaacg
     4801 gctctacaaa acgcataaca aaaaatccga tccttctgcg gatcggattt tattcttata
     4861 ctgtgagaaa gtcaggtaag gtgaaggtat agatggtgcg tggacgacct tgttgatagg
     4921 tcatctcttc tccagttgcc actaccaact tgtgatccac gcattttttg atgattcgtt
     4981 cagttgaacg gcgtgtcaca cctagaaagt tctccaagtc ttgagctgtg aactgattgg
     5041 aggggtgaat ggcataaaag ctaatcagtt tagacaggtt cgctggactt aggcccatcc
     5101 gtttggcgag cagcacttga ttgggttgcg tcaactgaag ggtgatgcgc tcagaggaca
     5161 tagggcttga taagtttttc tgtgcatcca ttatatagat gccgccctcg ctgctaaaat
     5221 ctagtgcgtc ttctgcatga cgtgtcgcag tcaaaatgtc gagaccatat ccaatcccgg
     5281 tgcgagctct agatgtctct agaaattcgc ggaactcaga ttgttccatc acgaattcta
     5341 cgtgtttgcg agttgtgata aattgatctg tatcctcatt gtacggaaac caagatcctt
     5401 ggacatgccg acgaattgtc gcatgaaatg tagggtccgc atgagattta ctgatgagca
     5461 tcactgcagg ctctgctttt tgacttttgg aaagccgggc taaataagct gtctgagcga
     5521 gtgcccgaac cagtgtccgt ttcagctctc gcatgtagac agagcggtat cctttttgga
     5581 ttaattcctc gtgaactgca tggatgctag ttatggctac tcgaacacgg ccactttgtt
     5641 gagcataaga atgaaactgc acgacagctt gctgggaaat gttcgggtcg atctgcaaga
     5701 cggcacctat ggtatgccca ggtgaaattt cagtaacaat ttcatggata agcacggggt
     5761 cagtcaagtc tatggaaatg tcttgtggag ctacttgatg aagccaacct gcctgcaata
     5821 aagtggctgt aacaaccgct tcatcttgtc tcataacata gacgggcagt tgacgttcgt
     5881 ccagtataga ttttgcatgg tagtaaggga aagtccctgc gaagaataca gcatccacat
     5941 taggcaagtc gctagcgatg gttcttgctt cagtagaatg tttatacgta taataaataa
     6001 aatgaatgtc tgagaactca gaagccaatt cgcgaattct cggagcaaat aattcagaac
     6061 ttacgacagc gatggtcaat gccaaaaaat caccccgttt cacctatata acgactattt
     6121 aacgacaact ataaatgaaa ctattttctt tgtaaaggat gagatgaaat gaaaatcaca
     6181 caaatcgatc tttatgcaat tcgcctacct ttaattacac cttttgtagt cagctatcac
     6241 agttacgctg atatgccttc gctgattgtc aaaatcacga ctgacgaagg aatcgtaggt
     6301 tacggagaag ccgtggcaga tgatcacgtg acaggcgagt cttgggagag tacttttgct
     6361 ttaatcgagc attcgttggc tcctgctctg atcggacata atccaatgca ctttgaagcg
     6421 ctgcacgact taatggattc tattgtgtat caagctccag cagcaaaggc agctcttgat
     6481 attgcttgtt tcgatgctgt tgggaaaaag ctaggggttc ctgtctatga tttgataggt
     6541 ggacggtacc acgagcgttt cccgatcacc cacgtattaa gtatcggaga gcctgctgcg
     6601 atggcagaag aagcacgtga acgaatggaa caagggtaca gctcgttcaa aatgaaagtc
     6661 ggtcgcgatg tgctcagtga tgtagctcga atccgtgccg ttcgtgaggc agttggagac
     6721 gatattgcca tacgggtaga tgtgaatcaa ggttgggtta atgcctcatc taccttgcag
     6781 gctattgaac tgatgaaagg cttgaacatc gactggttgg agcagccggt gaaagcagat
     6841 gatatcgaag gaatggtcga aatcaaagcg aagtcgacaa ttcctctcat gattgacgaa
     6901 ggaatgaagt caaagcgtga gatgcgacag gtcattcaac aaggggcagc gcataaagtg
     6961 aacatcaaac taatgaagtg tggcggcatc tacccagcag tcaagcttgc tcatatggcg
     7021 gagatggcag gactcgattg ccagatcggt tctatggtcg agtcgtccgt cgggtctgca
     7081 gcaggattcc atgtagcttt cgcaaaaaaa gtattttcta gtgtggaatt gacagggcct
     7141 ttgaagttct caaaagatat tgggaacctg cattatgatg tgccgttcat cgcgctgaat
     7201 gatcaagcag gactcggagt agatgtagac gaacgtgtat tggaagaatt gactgtgcgc
     7261 cgtactacaa ttggccagga gggagcttga tgagtttccc taaagacggg tttcgcatga
     7321 cacttttaaa tttgcagcat ctagaagcca ttgaacggct tcaagaccga gtggctgctc
     7381 atttggagcg agtagaccag cttcagaagc ttacacatga cgaaatacga atcattttgc
     7441 atcaagagct gtttgccggt gtctggatag atgaccagtt agtggcggca cgcgcttttc
     7501 tttacacccc tgaagacgaa gagcatcttg ctaaagatgt tggtatccat gtagatgaat
     7561 ggaaagacgt gatctattcc gagatttcat tagtagaccc atcgtaccaa gggcacggcc
     7621 ttcaaaagaa aatgggagct tggtggatgg agcgtctcca gacatcacct tatcgctatg
     7681 tatgtgctac tgtagctcca ttcaatattc caagtatgaa agacaagttc cagttgggaa
     7741 tgtccattgg agcgttaaaa gtgaagtatg gaggcaagct gcgctatatt ttcgtacgtg
     7801 atttgcaaca gacacgtgaa gtgacagaac tccaagcagt accaatggca gatacagaga
     7861 tgcagcaaca gcttttggcc cgtggagcgc gcggagtggg acttctcgaa caagatggag
     7921 catggctcgt gcagtacacg attgttgact gacaattccc tctattcaag agggtgaaat
     7981 tccgttaaac tgagactaaa agctcgtaag gcggtggcat tcacatgacg atcaaaacat
     8041 ccatgttggt ttttggtctt gtgctgtctg tcgctgcctt tttctatgcc tttttttggg
     8101 ccaatgtaga tccctatcac attgtcatcg atgtgatagg agcgggggcc ataggggtat
     8161 tagtcggatg gttagtggcc agtcgccgta aattaactga tgaacgacgt ctttccattg
     8221 aagaagtaga gacaaagcgc aaagagttgg aagacattca gcgagagctc gatgctttgt
     8281 attttaatag cagtgcttgg atttggagca ttgatttaga gcgagagaaa ttaaaagtct
     8341 caacaggaat tttagagctc tttggttatt cacaacaaga gatcgaagac gattatcaaa
     8401 tatggttaac aaaagcgtta gaaagtgata aatatatcgc agagcgtcat ctggagaagc
     8461 ttcttcgagg agagcgatct gaagcagaat ggagactgta taaaaaagat cgctctattg
     8521 ctcatatccg ttcaatcgga gaacccattc gaaatgacga gggcaaagtt actcgaatcg
     8581 taggggttac atttgatttt tcaaaagaga tcgagctgca ggagacgatg agccggattg
     8641 ctatgacgga cactttaacg cagttgccga accaagtgta cttcaatcgc cagttggaag
     8701 tgcgtattga agagagtgaa gaagacgagc agttggcact tatctacttc aatgtagatc
     8761 ggttgaagtt tattaatgac atgttaggtt ttgagacagg agatgaaatt ctgcagctga
     8821 ttgctgaacg gatgccgatg tactttggac acgatactct gatggcccgc tatggtggag
     8881 atgagttcat cattgcttat ccccatcatg accgtgaagc catgcagatg aagatcaatc
     8941 aatttatgga gtcgttccat acgcctttcc atacagcaga agacgaattg ttcgtcagtg
     9001 taagtatcgg agtagctttg tacccggatg atgccgagag tgtgaacagt ctgttgtcta
     9061 aagcgaatgc ggctttaaag cgagccaaac gaaaagggaa aaacaacatc caattctata
     9121 tacgagaaaa tgaggagctt caaaaacgga agcttcggat tgagcatgac ttgaaacgag
     9181 ccttagaatt tcaagagttt gagctatatt accaagccaa agtctctttg atgtcacata
     9241 gtgtccaagg agccgaggcc cttatccgct ggcaccatcc aatcttagga gagatctcac
     9301 ctgctgaatt cattccgatt gctgaagagt ctggccagat tgtgccgatt ggtgattggg
     9361 tgttgaaaca agccatccat caagtgaagt tatgggaaga agtgggaaca cctctacgtg
     9421 tcgcggtcaa cgtttcgagt gctcagctgg aagtgactga ttttatggac cgtttgcagt
     9481 tgctactttt ggaaagtggg atcacaccga acctacttgg aattgaattg actgaaggca
     9541 tggtccaaaa tgtagaagcg gccgttccga ttctgtttga gatgcgacaa ctcggtgtga
     9601 gtatctacat tgatgacttt gggaccggct attcatctct cggtatctta aatcaattgc
     9661 ctatcgattt catcaaaatc gacaagtcgt tcatccaaga aattccccat aataaagggc
     9721 aagccacttt agtgaagacg attattgaga tgggccggaa tcttggattt gaactcgtgg
     9781 cagaaggcgt ggagcgagaa gagcaggcgg agtttctgct tcagaacggc tgtaccaaag
     9841 ggcaaggctt ttacttctct catcccctcc cagttgccga gtttgaacaa cgctatttac
     9901 gctaacctct ccttagggag gggttttttg atacaataga aggtacgata gttgagaatg
     9961 gaggattctt gtgaaggcca gtccagaaac acgtgatgcg atgcgcgttt taaaagaaac
    10021 gagccgcacg ttttacatac caattacttt tctgcaacgc gatcttaaga aggcggtcgc
    10081 ttccgcttat ctctgtatgc gtgcaattga tgaaatagaa gatcatgaag acattcctaa
    10141 agaactgaaa gcagacattt tattaaaaac agcaagtcta ctagaatcat cgtttgatga
    10201 agaggcgtat ctacgagcgc tcgagccgat tcaacacttg atgccagaag tcacaattcg
    10261 cttggcggac tgggtcgcgt attgccctga aggagctaga aagcgaatgc aactagctac
    10321 tgctgagatg gcagagggaa tggccaaatg ggcactgaaa gaatggaaag tggagacgca
    10381 agaagactta gatgactaca cgtactatgt agcaggcctt gtcggtgtca tgctatcgga
    10441 catgtgggaa tgggattcag gaattcgtac agaccgagac ctcgccattg gatacggtcg
    10501 aggattgcaa gccgtcaaca tcttgcgcaa tcaagaagaa gattcggaac gtggggtcgg
    10561 ttattttccg aagcagtgga ctcgtgcgga tatgttcgct tatgcggaag ccaatctcgc
    10621 gaaagccgat gcctatatgg aagacatctc caagcgcagt atccgtttgt tctgccagct
    10681 gcctttaaca tttgctcaca aaacgatgga cgccatgaag catggacgtg aaaaaatgac
    10741 ccgagcagaa gtggaacgaa ccgttcaaga agtcgcaggg agcgattggg aggaaagagc
    10801 atgaaaaaat taaaatggtt acttcccatc atggtgatct ctgcattttt ctccgtgctg
    10861 attttacgag atcatccaga tgtgacattc caaaataaag tgttgattac gataggggct
    10921 tctctagtat cggcactaat aggctttatc ttattacgac aagacatcga taaagtcgac
    10981 ccgaaaccaa aggagaaact aaaatgacta aaaaattatg gtttcaagta ggagtcgcga
    11041 ttttgctgac tcttgtgatt atccgaatgg ttgtggaagt gcaggcgatt ttcaacccgt
    11101 tctttgtgat tttacgcacg gtatttttgc cacttttaat tgggggcgtg ctgttttatc
    11161 tcacacgtcc tttagtgaag ctattagaga gaaagaaagt gcctcgttgg ggctctattt
    11221 ccatagtggt tatcttgcta cttgcagtca tcgttggatt cacctcaatt gttggacccg
    11281 tattgactaa tcaagtgaac gcattagtga agaatggtcc agttattatc aaagaaattg
    11341 aatcgatgac agactacgtt ctagaccaac gagaccgact tcctgaatcg atgcaggact
    11401 ctattcaaga tgcagtcggc agagccaatg agtttgcggt ctctggcggg actttgttaa
    11461 tcaacttctt ccaaggactg ttccaaggaa tctttatgct cgtattggtg ccgttcttct
    11521 taatttacat gctaaaagat catgaaaaac ttgctccatt tgttgcgaaa ttctttaaag
    11581 gtgagcgtaa gacgtggatt cgcaagacac ttgcggatat cgatgaaaca ttaaagacat
    11641 acatacaagg ccaactactt gtcagctttt tagtaggtgt catgttgctg attggataca
    11701 tgatcattgg tttaaagtac ccactgttac ttgccttgtt tggcatgctg acaaatgtaa
    11761 ttccattctt gggaccgtat ctagcggtca ttccggcgat gatcattgcc tttactcaag
    11821 agccaatcat ggcgctgtgg gtggctctcg tcatgttggt tgctcaacag attgagagta
    11881 acctgattac accaaacgtt atggggaaat cactcgacat ccatcctttg acagtaatca
    11941 caattatttt gtcagcagga agcttagcag gcttgtgggg aatcatttta gcaatcccgg
    12001 cgtatgcggt tgtgaaatcg attttacgta acatctacgc gtatcgtgaa gagattcggg
    12061 atacagcgaa taaagacgtt taaaaaaggc agtttctcat tgagaagctg ccttttctaa
    12121 gttctgtccc ggactctttt gttatgctga aacctcgtgg ctgaactgcc actgaatccc
    12181 atattgatct tgtacgattc cataagcttt actccaaaac gtttcttgga tgggcatgag
    12241 gacacgcccc ttttcggcaa gcaagttgaa ctgttgcgtt aaaagatcgg cgtcatcgcc
    12301 aacgattgcc aaagtgattc cgtccccgtg ggtaactggg ttttgcggca tcgagtctga
    12361 aaagaagagt ggtgaaccgt gaaccgtgat tcgtgcgtga agcacacggt ttcctaactc
    12421 tggatcagct tcatgtccag gcatatcttt aaaatattga atgtgaggag cttctgttgc
    12481 aaatacctcg tgataaaaac gtaccacttc ttctgtgttc ccattaaaat tcaaatacgc
    12541 aataactggc atcctttttc ctcctaatcg attggacaaa atccacattt gagctgtcct
    12601 gcaatatctt ttgcaagaca gcaggttgat cgaactggca ctctcgtcaa atctagagcg
    12661 gacctacccg caacaaaatt agagaacttt gcggcccctt ctcctaagtc agggttttgt
    12721 aacaacatcc agtcagttaa cgccttttcc cataaatcgg cttgctgtag aaaaacggaa
    12781 taatgccaaa ctgtgtatcc aaaaatattt tcccagtgaa tctgctgaat ggcaggcgat
    12841 gtcgaaagag acgtgaccac agtatctgct aggttccaaa tagcttgcac agcatgaggc
    12901 ctttccgttt cattttgcag cggcacatag tgttcttctt gcacaaaggc actaatagcc
    12961 ggattcccat attcacggac caacacccac tgcaaattgt ttggatctcc cacccatcgt
    13021 tcatcataaa gagtcagatt ccagaattgc atggacaaga aaagacctag acgacgtgtg
    13081 agataagaag cggctgcagt tttgtgtggc gcctggatga tttcttgaac cgtcgtcaga
    13141 tgctctttcc attctcctgt gtgaaagagg acaggaccag ccggctgcag gtaaacactg
    13201 tattgagtta gttgctggcg ctgagaagta gttaacatag tttcagtata aaagattttt
    13261 tctgactctg cttgactttt taattgaaaa tgattatcat taccataagg tcaacaagcc
    13321 atcgtgcttt tctccaaaaa ggacacgatt gtctcgcccc cctcaaatgt gagacacaaa
    13381 acgaaagcgc caaccgctag ggttggcgct tattttcatg ctttcttcgt ttcgcgacgg
    13441 acatctcgga agaagaagaa ttcataaatt acaggcacta tgatcagtgt caacaatgta
    13501 gaagacgtca acccaccgat tactgtgata gccagtcctt ttgaaatcaa cgttccagaa
    13561 gatgtagtga gcgcaagagg gatcaatgct gcaatcgttg caaatgcggt catcaagatc
    13621 ggacgcaaac gcgtcttccc agcttccact aatgcttcgc gtatcggcat ccctttgtca
    13681 taacggttct ggttgattcg gtccaccata acaatggcgt ttgtcgttac aatcccaatg
    13741 agcatcaaga atccgatcat cacactaacg gatagaggtt cttgagcaat cagtaagcca
    13801 aacaaggctc cgattggtac gaacaatagg gaagagagga tgacaaacgg gattcgtgct
    13861 tttccgaatg taatcagtag cgtcaaatac acaagaccaa tcgcactcaa gatagcgata
    13921 ccgagctgtt ggaacacttc aacagtttca tcactaccac cgccaccttc aagtgataca
    13981 gattccggaa ggtcgatgtc gctttccact gcagcgagta catctgtaga aacagcacga
    14041 atattttctg cgtttacttg tgcctccact cgagcaaaca cgcgaccgtc tagtttctgt
    14101 atagaagtaa acgattcaat ctgttccacg tctgcaactt cagacaaggt gacgggacct
    14161 tgagttgtga acaacgtcaa ctcttcaatt tcttctggcg aggtcacgcc ttcatcataa
    14221 gacagctgaa cagaagggcg gtcctcacct atctgaagtt ctccgagttc aacgggacgt
    14281 gtctggtcag agatagcacc gaggatttgg aaaccagaga tgcctcgagc atctgcagct
    14341 tcagtattta ctgtcacaac aagttgttct tgcttttcag agaaattgtt gcttacatat
    14401 ttcaaatcgt cgcgctcaga aagcaatgct tccacttcag cagcggcttg ctccagatcg
    14461 tccaggttgg tcgagaacaa gtcaacgacg acattgttgt tggttggtgg acctcctgta
    14521 gacacttctg agacagaaac tgttgtctgg tcgttgatac tagtcactaa ttcatccata
    14581 tctgtagctg ctttatctaa gaatgcgtct agatcggcat catcgtttaa agagataaag
    14641 taaccggctc ggttaacgag tttgatgccc gttgcaaagt cacgtgcccc aacggatgtt
    14701 gtgacgctgt ctacttcgtc atacccgagg agcagctgtt cgacttctaa agagacttca
    14761 ttagtccggt caagtgtcgt ggaggatgga agctcaatgc ttgcctgtac aagacgcgac
    14821 tcttcatcag gtataaatgt aaatccaaga cgtggcacga tggcaaatga agctcctaaa
    14881 aggacgagtg agatgagcaa gacgagccat tttcggcgta atgaccatgc gatagcacga
    14941 ccatactgac gttgcaggac gtcttctttt tcttcttgct tgatcttctt gaacgaaaac
    15001 ttcgctaaaa tcggaacgat ggtaattgct acaagtaaag aagctagtaa cgagaatacg
    15061 accgtcaaag caaatggcaa gaagaactct cctgtaatcc cgcttacaaa gcctaaaggc
    15121 aagaatacga cgaccgttgt gatggtcgag gatgtgatgg cttttaaaat ctcttttgta
    15181 gaggtttcca ccatctcgtt ggtcatttcc acaccaggct ttctgaggcg cctgaaaatg
    15241 ttctcgataa ccacgatact gtcatcgaca actcgtccga cagcaacagc cataccaccg
    15301 agtgtcatga tgttgagagt gattcctagt tgattcaaga aaatcgctgc aatcaataaa
    15361 gacagcggaa ttgagatgat ggcaatgatg gttgcacgcc agttgcgtaa gaaaatgagt
    15421 actgcgatgg atgcgaatag agcaccaagc aacccttctt ttacaagcgt ttcaaccgat
    15481 ttttcaattc cttcagcgga gttgaagccg atagagtacg aaagctctcc atcatacttc
    15541 tcaagtactt ctaacacttc atctgccact tcaacagtgt tggcatcttg ttttttcgtg
    15601 acggccatcg agtaggcttc ttcatcgttg tagcgagtga tttcatcctg tgtctcgact
    15661 tcttcaatcg tcgcaatgtc cccgagtgtg acgggtggcg ctgatggatt gaacgagttc
    15721 tgtagagaca gcgattccag atcgtcaatg gattctagta cttgttccac tttgacagga
    15781 atggtgatgt cgttttgttg tacttgtcct gctgggaaac taaagaactt ttgatcaatc
    15841 tgatctttga tctgaccaag tgtaaggccc gcttgctccg cagctgcttg gtctacagtg
    15901 atttgaagct cggtatctgt aagtccaccg acagatacgg agttcacacc aggaattttc
    15961 gagagctctg ggatgacgtc cgtgtctagc aactcatcaa gatcgacgcc ttcttcagca
    16021 aataatgaaa tattgaaaat agggaaggcg ccaaacgaaa ggcgactgat ttcaacagtg
    16081 gcttcttcag gtagaccggc ttctgcaatc gcagtatccg cttgttgctc gaggcgatct
    16141 aggtcggtgt caaatgggaa caccaagttg atgacaccaa ttgtgtcata agacgcgctc
    16201 tgaatctctt gcacaccttc aagtccttca aatgcttgtt cgagcggggt gatcacttgc
    16261 tcgttaacat catctggaga cgcgccagga tagacgatct gtgcagagag ctgcgggaat
    16321 tcaatgtttg gaagtagatc gattttcaga cggctgaatg aaaacaagcc gagtaaaatc
    16381 agtaagaatg caaatataaa tacggcaacg gcgttacgta gactgaacct agtaatccaa
    16441 ctcattgcgt ctcctccttt aaaatcctgt aatgacaatc tggtcaatct gctgacggat
    16501 ctctgtcaag cgttcttcat tgaacgaagg atccataaaa atctcatttc gaaaactgtc
    16561 gagcatacct acataaagcc ttgccttcgt ggcggcattt tctatcccat gctgctcgaa
    16621 aaattggcga atcaattcaa tatacgcttc gatgaagtcc atcaaggcat ccatcgcttc
    16681 ctcatgttta tgattgagct gcaaatacat tcctgaccga tggcgttgtt tccagatatt
    16741 ctgaaggtgt tcttgcgaga tggcttggag cgtttctgga aatgtgcgct gattctggat
    16801 atgacgctca attgtggtca aatacattga aaacgtaaac ttcatcatat ctgtatacaa
    16861 ttcttctttt gaaggaaaca tggcgtataa agtagatttc gatatttttg cgaggcgagc
    16921 aatggtcagc atcttggctt caaaaaagcc ttctttacca aaggtttcaa gtgctgcaaa
    16981 taagatgcgt gaacgtagtt cttgctccgt catatctctc cccctttttt agagtacccg
    17041 tgagtactct gaatgtacac cctttgtata aagtttgtca aacaaaaacc acgtaccttt
    17101 taagatacgt ggtttgaggt cgtgtgcaat ttttgttttt gttcccaaat agtatgcaaa
    17161 ctatgcgcaa gaagtccgag gacgatgatg cccatcccag ctaatgcaat aggagcgggt
    17221 agagggagtt gcagtagcac catctctccc gctacaacga ataagatctc tgtagactga
    17281 gtggcttcta cgctagctag gcgactttgg ctatgtctcg ccatgtcagt agccatgaag
    17341 aacagcacgg tcgcaatcac tccggaactc acaccaacaa agaaggactg caagacctga
    17401 cttccagacg ggagaccgac tgtcatccaa gcataggcag ccaacaggat ccaagcggga
    17461 agggacgcta tcgtcatccc aagaacgcgc tgataagagt ctagtcgact tccgacgtgc
    17521 tgcatcatct tgcggtttcc aagagggtaa gcgaatgcag ccaccacaac gggcaaggac
    17581 ccgagcagca gtgtcgctaa gggaacggac gctgcttgag gcaaatgaag caggaaaatg
    17641 ccaactaaaa tcactcctga aattactaat gcagcgcgag gaatcacttc acgattccca
    17701 tcattcgaaa gaaacagggg agccagtaaa attcctgcga caatcgtcag ctgccacatc
    17761 ccggcaacga gccatccagg accaaaggca gctgcataag tcagaggagc atagaacagg
    17821 acgaagccga caaagctcca gatgaaccaa ggtccgggac tcgttctcat gtcacgagca
    17881 agaggtggca agccaccacg catccagacg atgatgacaa ggaacggcac catgaaaaag
    17941 tagcggagcg atgcgcccca catccaactg ccacctgaga gctccattgc atgattcaac
    18001 acgaatgtca ctgcaaagaa tagggcagcg acaattccta aacctatagc cttcatcttc
    18061 gtcccgccct ttccttactt caatgcagcg cgcttgatga tttcttgtac gacttgagtg
    18121 gctttttcca tattttcaat cgagatgtac tcaaacttgc cgtggtagtt ttctccgcct
    18181 gtaaagatgt ttggtgtcgg catccccata tacgaaagct gagaaccgtc tgttccgcca
    18241 cgaatcggaa taataagtgg ttcaatttct aaatcttcca tgatggcttt cacgtgatcg
    18301 acgatttcca tgactggtgt gattttttca cccatgttgt agtattgatc gttcaactcc
    18361 acttcaattg catcgtcacc atactgcgcg cggatagccg aagcggcatc atggaatcgt
    18421 tgtttctttt cttcgaactt ggctttgtca aagtcacgga tgatgtaatc catcacggtt
    18481 ttctcgactt taccgtggat atccatcaag tggacgaagc cttcgtaacc ttctgtcttt
    18541 tcaggtactt cttgaggagg catatgggac tggaatttca tcgccatcgt gatggcattg
    18601 accatcttgt ctttcgcgga gcctgggtga acgctcacgc catgcgtcgt cacacgagca
    18661 ccagcagcgt tgaagctctc gtattgaagt tctccaagag ggccgccgtc catcgtgtag
    18721 gtatagtcgg caccaaacgc agcaacatca aacttatgtg gtccgcggcc gatctcttcg
    18781 tctggtgtga aaccgacgcg aatcttgcca tgttcgattt caggatgttt caagaagtag
    18841 tccatagctg tcaaaatgat agcaattccg gccttgttgt cagcgccaag aagcgttgtg
    18901 ccatctgtcg tcatcaatgt atggcctttg tatttaggaa gctctggaaa atccgatact
    18961 ttcatagtag tcgtagcatt caatacaagg tctttcccgt cgtagttctc tacgatctga
    19021 gggttcacgt cttttcctgt gtaatccgtc gctgtatcga cgtgagctaa gaagccgata
    19081 gtaggcacgt ctttttccgt cgttgcagga agggtagcaa acaagtagcc gttatcatcc
    19141 agtgtgattt ctgtcatgcc catcgtttga agctcttgtt caagcaggcg aagcaagtcc
    19201 cattgtcctt cagtagaagg agttgatgtg cttgcagcgt cagactgcgt atcaatttta
    19261 gcgtagcgcg tcaggcgctc gattagcgtt tgtttcatag ccaggatggc ctccttgtta
    19321 tttttcagta aataagcgct gcacggcgcg ctcaattgta gagatcgtat tgacgtcttg
    19381 gaagctgatg ccaagttgga cagctgtttg cgcaatctct ggtcgaatac cagacaaagt
    19441 agactctacg ccgagcaaac gaagtgcctc gattagttgg aagatttgtt gagcgaccat
    19501 cgtatcgatg atagcaactc cagagatatc gatcagcaag ctctgtacgc gcttttgtgt
    19561 acactgtgtc aacgcatttt caaagatgtg cttggcacgg tttgtatcga tatctccgac
    19621 gagtggtagt aacgctaccc cattgctaag agaaataaca ggtgtactta attcgttgat
    19681 catttcttgc tgtgcgcgca atttctttaa cgaatagttg tgatgttcct ctgtgaacca
    19741 ggtcattaat ttactgaagg ttttcgtgac cgtagcaatc cattcttgaa ccgtttcatg
    19801 agtgaggtca ctagcttgtc gttcatatct atacaacaag tgtatgtatt gttgttgggt
    19861 gttgaagaat tcctgcaaaa taaagtgcag tggggtattg aggtgttcgg gatctcgagc
    19921 gatttcaagt acccatgctt cgaattcttt taagaaagta gcttcatctt gaacaaatac
    19981 cttacaaaag cgttcatgaa agccgtggtt ctgttgcttg attgtctcta taactgtggc
    20041 atcattcgat gcatagacgc cactagtaga ttctttatct agagccgcat accattcttc
    20101 tgttaagtcc cacgtgtgtt tttgcaaata ctcatacagt tcttgattgg gtgtcatccg
    20161 cgtttctctc ctttttattt cgaagttcct acgctctagt gtagtggaca gagaagacaa
    20221 taggcaagtc cgcactggac ctgcctaaag aattgttata gagcttcgtc atccacgttg
    20281 ttcagatacg cttcaatttc ttctacgaca ccttcgatgc tgcctggctc aaatggagat
    20341 ttgaggttgg ctgcttccac aagtttcgtg aacggaagag atccgccaag agtgcacaag
    20401 tacagataat ctttccatgc tccgtcgaaa tcttcgcgtg agcgtttcca aaattggaat
    20461 gcacagatct gagctagtgt gtaatcgatg taatagaaag gtgatgcata gatgtggcct
    20521 tgacgttgcc agaacgcacc ttcttctaga tatggattgc cgtcgtaatc gcggtgaggc
    20581 aagtacgtct gttcaatctt tttccaagca gctttgcgct cagcaggtgt catctccgga
    20641 ttttcataga cgacgtgttg gaattcatca actgctacac cgtaaggcaa gaacaacaga
    20701 ccgctcatca agtgagagta tttgtacttc tccgtctggt ctttgaagaa gttctccatc
    20761 caaggccatg tgaagaattc catactcatc gagtggatct ctgc
//
