LOCUS       NZ_NUOG01000083        26487 bp    DNA     linear   CON 31-JUL-2024
DEFINITION  Bacillus sp. AFS033286 AFS033286_82_A2_Contig38_140604, whole genome
            shotgun sequence.
ACCESSION   NZ_NUOG01000083
VERSION     NZ_NUOG01000083.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus sp. AFS033286
  ORGANISM  Bacillus sp. AFS033286
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 45856)
  AUTHORS   Bleich,R.M., Grubbs,K.J., Santa Maria,K.C., Allen,S.E., Farag,S.,
            Shank,E.A. and Bowers,A.
  CONSRTM   Agbiome Team Llc
  TITLE     Large-scale bioinformatics analysis of Bacillus genomes uncovers
            conserved roles of natural products in bacterial physiology
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 45856)
  AUTHORS   Bleich,R.M., Grubbs,K.J., Santa Maria,K.C., Allen,S.E., Farag,S.,
            Shank,E.A. and Bowers,A.
  CONSRTM   Agbiome Team Llc
  TITLE     Direct Submission
  JOURNAL   Submitted (07-SEP-2017) Chemical Biology and Medicinal Chemistry,
            UNC Chapel Hill, 125 Mason Farm Rd., Chapel Hill, NC 17599, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Assembly Cell v. 4.2.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 78.73x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002583065.1-RS_2024_07_31
            Annotation Date                   :: 07/31/2024 14:02:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,319
            CDSs (total)                      :: 5,247
            Genes (coding)                    :: 4,997
            CDSs (with protein)               :: 4,997
            Genes (RNA)                       :: 72
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 250
            CDSs (without protein)            :: 250
            Pseudo Genes (ambiguous residues) :: 0 of 250
            Pseudo Genes (frameshifted)       :: 83 of 250
            Pseudo Genes (incomplete)         :: 197 of 250
            Pseudo Genes (internal stop)      :: 59 of 250
            Pseudo Genes (multiple problems)  :: 74 of 250
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:15:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4242
            Orig. end                         :: 30729
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NUOG01000083.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26487
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26487
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26487
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16487](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16487)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    49..64
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.38"
                     /tool="antismash"
     misc_feature    complement(50..63)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 22.59"
                     /tool="antismash"
     misc_feature    complement(349..362)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.65"
                     /tool="antismash"
     misc_feature    complement(992..1007)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 24.01"
                     /tool="antismash"
     gene            1001..2701
                     /locus_tag="COE07_RS24835"
                     /old_locus_tag="COE07_24840"
     CDS             1001..2701
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000520221.1"
                     /locus_tag="COE07_RS24835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24840"
                     /product="hypothetical protein"
                     /protein_id="WP_088233008.1"
                     /transl_table=11
                     /translation="MGKSFIIRNQRSLNGQSTNAVLVTLKSWQKLVETFEEKYYSYKDT
                     YLEDIVNQMTYEERIADVDGFVAQAKPSFSRRTLSAISETMGRKHKLYGLTNADLEVFL
                     YLHKKCYTNGVIPNVTIHMMWEDYKLYKEEFAYIQHSQFYIALKKLSIHNIITIENELD
                     GRYTIKLTHFMNEETEKANAYVYISPVVFTKAFFELSVASKKLFLDIAMQQHSETTLKR
                     SLDKQDEKGNKTHFGGMYRFLHKKYPHQIRAVMTELTTALPCTGTPLFKICKLQKGVKN
                     KKRYTTLYLSLHTDFLCAKETGEVQYRDPFTPKLTYARKARFIESVLQEMNIGEFTQDM
                     NKFIHVLKYTCHRQIRSVIHSLRDMIDRNEEYPSKLVYTLKKLLNQTSQYQILDTAAKE
                     GIYPLITQHVPKEQKEQAVFDFGLHFSMYSLRNIKKLFRKTYELLNYKFAVPVTEESYH
                     RNYLKYQEETLFRKYAYEQGTNLNAYMALEIEIRELLKVRGHKERSIPSDVRELFIEKI
                     DRLPKEKLRVIEVPDNFNLITFMRAFEQLIRAGIPVTTAEQVLTAMKTN"
     misc_feature    2718..2731
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.54"
                     /tool="antismash"
     gene            3841..4131
                     /locus_tag="COE07_RS24840"
                     /old_locus_tag="COE07_24845"
     CDS             3841..4131
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002193576.1"
                     /locus_tag="COE07_RS24840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24845"
                     /product="hypothetical protein"
                     /protein_id="WP_170933801.1"
                     /transl_table=11
                     /translation="MSQYQMLYSTPYLYSSRTLNQMYKANKNEENICAIQEHMLRHEVY
                     LNQQYRGYYYLSQKIEEELYGEEHALSWNELLDDYQLYRDRKGNLSIKPKG"
     gene            4139..4324
                     /locus_tag="COE07_RS24845"
                     /old_locus_tag="COE07_24850"
     CDS             4139..4324
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016128467.1"
                     /locus_tag="COE07_RS24845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24850"
                     /product="hypothetical protein"
                     /protein_id="WP_070146758.1"
                     /transl_table=11
                     /translation="MTIIGELGIVYGVTGASVLGVKLLKKKGLYLPGWLLRAGLKCLLI
                     GSVWYVLMDILDVFLR"
     gene            4425..5606
                     /locus_tag="COE07_RS24850"
                     /old_locus_tag="COE07_24855"
                     /pseudo=""
     CDS             4425..5606
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016110326.1"
                     /locus_tag="COE07_RS24850"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24855"
                     /product="FtsK/SpoIIIE domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLSLLLIPATFITVAYFYQSNGMSDKKKIATFFEIAKICVQHKGE
                     LQYPIFIKEMKDDISMNYVYKLPLGVPSQLIQKLAEVLEEGLYKPVKISFHQRELHIRV
                     FSQQIPEMWNWSKDLLKEHTWSVMVGKALDKYVYHDFEKTPHMCVSGMTRFGKTVFLKN
                     VMTSLILQQSQHVNFFIIDLKEGLEFSPYKELSQVVEVAENPKQALEMLAKVREKMVKQ
                     IEVMKKSYFTNIIDTSIKERCFIIVDEGANLCPTQGLPKKQRDVLFLCQEMLSEIARIG
                     GGLGFRLIFCTQYPTSDTLPRQIKQNADAKIGFRLPTTVASQVALDESGLEDLPSLPGR
                     ALFKTDRTEEIQVPYLKDTDM"
     gene            5545..6159
                     /locus_tag="COE07_RS24855"
                     /old_locus_tag="COE07_24860"
     CDS             5545..6159
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002107215.1"
                     /locus_tag="COE07_RS24855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24860"
                     /product="replication-relaxation family protein"
                     /protein_id="WP_088233006.1"
                     /transl_table=11
                     /translation="MRHQTLKQKARQIEILSTLGKLDFLTRRQLQAIHCLGSIRNANRV
                     LKDMPSYFHITKMARELVYYLNKKGRDLLGITKEVKKSSQLQHILMQNESWMWLGFPEW
                     KTERSIDFSINGQRYEIIPDATYFEDNVPHFVEIDRMQHMKANEHKIQLYGHITDIYKR
                     QNAIVPVINFFTLSDYRQSKLEQYATKQNVFMRTFVMDHIF"
     gene            complement(6165..6395)
                     /locus_tag="COE07_RS24860"
                     /old_locus_tag="COE07_24865"
     CDS             complement(6165..6395)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016128143.1"
                     /locus_tag="COE07_RS24860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24865"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000467332.1"
                     /transl_table=11
                     /translation="MFGLGKKRTPFGDYLDRRGIKQQWLVQKTGLSKSLISDLANKKDR
                     VPTLTSATKIIKTLRKFDNRIDYHDFWDINI"
     misc_feature    complement(6605..6617)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 22.01"
                     /tool="antismash"
     misc_feature    6835..6848
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.63"
                     /tool="antismash"
     gene            6868..>7699
                     /locus_tag="COE07_RS28650"
                     /pseudo=""
     CDS             6868..>7699
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018768025.1"
                     /locus_tag="COE07_RS28650"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="damage repair protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFDYSKWINQMIFCQLCMCYEGFRSTESKISCRWGYG"
     gene            complement(7723..>7924)
                     /locus_tag="COE07_RS28490"
                     /old_locus_tag="COE07_24880"
                     /pseudo=""
     CDS             complement(7723..>7924)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002191935.1"
                     /locus_tag="COE07_RS28490"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="COE07_24880"
                     /product="ATPase"
                     /pseudo=""
                     /transl_table=11
                     /translation="NTF"
     misc_feature    complement(8075..8087)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 21.58"
                     /tool="antismash"
     gene            complement(<8249..8401)
                     /locus_tag="COE07_RS24880"
                     /old_locus_tag="COE07_24885"
                     /pseudo=""
     CDS             complement(<8249..8401)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /locus_tag="COE07_RS24880"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24885"
                     /product="IS6 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRYFKGKQFKKDIILVAVGYYCRFSLSYRDVSEILKECGVLVHPT
                     TIMRWV"
     misc_feature    8536..8549
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.52"
                     /tool="antismash"
     gene            8613..9164
                     /locus_tag="COE07_RS24885"
                     /old_locus_tag="COE07_24890"
     CDS             8613..9164
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="COE07_RS24885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="COE07_24890"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_088233005.1"
                     /transl_table=11
                     /translation="MQKDLIKDGLLTGSCPEKYENGVDYHIFQGETSIYLKSKENVTHK
                     EFGTLMCTINADRYRGKRLRLTAVIKTEDVKERAGLWMGITGGNAELLAMDNMKNRPIK
                     HTENWKPHSIILDVEENAVEIATGILLFGEGCIWVTHLQLEELDKKMPLVNLKTNDCEC
                     LPIEPINLQFEELEEQEKKE"
     gene            complement(10001..11377)
                     /locus_tag="COE07_RS24890"
                     /old_locus_tag="COE07_24895"
     CDS             complement(10001..11377)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="COE07_RS24890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24895"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_088233004.1"
                     /sec_met_domain="LANC_like (E-value: 4.6e-74, bitscore:
                     240.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTTLKNNWKPIEDENLSYKISTLTLALSRLLQDPKKSKEHGLD
                     KKNIVRVENHELLPWQDLSLSHGYPGICLLMGELDRSFPEMNWDITGHEYMKAIQKSLN
                     EDTITSLSLWGGISGIIMGANGLSKGGTRYQNMINTLHTFFLNNYSNLLEESFAQINDG
                     VSMKNYDAIQGWSGIGRYLLEFQENPKIKQALLEVLEYLVKVSEHKYINGQYVPGWYIP
                     VDKLLLDSDKFSYPQGNFNCGLSHGIPGVLALLSLTQKKGIEVPGQVQAIENIAKWLLK
                     WTAYDEYGVYWPNCISWEEHVNGVLKGKSTHRDGWCYGSPGVARSLWLAADALGKDHWK
                     EKAIESYIATFKRPSSTRLLDSPTFCHGIAGLLYMTQCMWVDTGVKELKKLRDELVEEV
                     ISLYDSTAPLGYYDCIHENNQIRYVTKVGLLEGTTGIVLSLLSTIQTERPDWDSVFLLN
                     "
     gene            complement(11391..13262)
                     /locus_tag="COE07_RS24895"
                     /old_locus_tag="COE07_24900"
     CDS             complement(11391..13262)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010497959.1"
                     /locus_tag="COE07_RS24895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24900"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_088233003.1"
                     /transl_table=11
                     /translation="MSKVDKESLETLSILNVWRSFRFWPQVFGLLWGTQKFYLLIILIT
                     TGLQGITPAIILICTQNIVNSVIKAQATNSFDDVIFYFLLLISIGFMNEVISLIKNYFH
                     KLFESLLSNRVNILIMEKTINLSLTEFENADVQDQLKRSQSEANYRPYQIFMEILSIIS
                     GVIMLFSTASILLSWRWTTTILLIVVPITSFISLLRIGKQEYQLQYNRAPKYRQSWYLT
                     FLVTKDSSFKEIKIYKLGQYLLTRYRELFNLFYQENKSLVRRRTNISFFFKLLNQVVVA
                     YVIFLILHDTYTKQINIGQLVGMIQAVMMTQANAQGAVQYILSFCQNNLYMQQLFTFLS
                     LDSSDKLARSLHSKEIIENNSLDSIEQIRLRNLSFCYPNSKKLALDTIDLELNRGETVA
                     IVGKNGSGKSTLVKLMAQLYQDYQGDILINGKSIVSYPEDQFLQKIGVVFQDFVHYEMS
                     VRENIGFGNLMNVNNSDEVLKAAERAGIKDLVNQLPSKLDTQLGKLFKDGHQLSGGQWQ
                     RVAVARAFMRNADVYILDEPSSFLDPEAEIEVFDKFRKLVENKIGIFISHRFSSVSFAD
                     KIIVMDNGRIVESGTHHELMKLDGQYAKLYRLQMSNFAKEENLVSNH"
     gene            complement(13263..16487)
                     /locus_tag="COE07_RS24900"
                     /old_locus_tag="COE07_24905"
     CDS             complement(13263..16487)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="COE07_RS24900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24905"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_088233002.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.3e-182,
                     bitscore: 599.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.6e-15,
                     bitscore: 48.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3e-38, bitscore:
                     123.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITKEDDLKNTSLTTESSIFCALDFFMIRTPLLPIEVYKECFDLV
                     GKQDIEQYEMGIENLQELSSNPVIRETIAVASNALHSSLDNINLSTNNKKKRQTIDSFS
                     RYLNRMTTRPTPYGIFSGVSHGKFHNLGNISLEGVNQFKKRARADMEWLLKLVEVLEKS
                     EEIMDDLYITTNTSAYKNGNRLKIPYHTGYGQQLTQENAFVINYHSISYTPVVKQVLEI
                     AKERLVFKDLIKEVSNLYPDTSKAIIYKFVKQLLNEEFLISELRPPFMCTNPFNHVLNI
                     LLRVDKNSNFTTELVEIKEYIEQYNALSIGTGENLLKLINHKMNSIVQVKNPLQVDLVI
                     KEKNNTLTYEIKENVEKAAELLWKLSPPVIGFSHLSQYRNEFLEKYGPYREVPILDLLD
                     EDIGLGAPATYKYPKSPYSYNEPISDFQKNREKFLNKWIMEAVNKGEMEIEIDHNRLKD
                     IEDNEVDDEKAPLSMELYFSILSRSKDALNKGDYKMILSPNPGSEGAGKTFGRFIDLFD
                     TEVTEKMNSIHNLEQEIEEDAIFAEIVYLPPAGRNSNVALTENIRPYEIVIGTNSSKGA
                     NHTIPLSDIVVGATFDSFYLKSKSLNKKIIPTNNHMLNYLTAPNVCRFLAEIGLEGRKR
                     WMSFDWGNLGDLPVLPRIKSGNIIISPAEWKINQDTFDKQDINETHKWNNLINIWRDKW
                     KVSKYVFLTVGDNRLLLDLDNPLHLEIIRKDYTKLTSGQSLRLIEVDDDILDSWVTSEQ
                     GTYLVECVFPLVKKHNERLSNVIDAPREDINKTIIGDERLKFPGSEWLYVKLYGMGQRQ
                     EEFISKSLKEFVHSAQKEGWLDSWFFIRYADPKHHLRIRFKGDPHLIQTKGLIAFYKWS
                     QQLREEGMLSNLTIDTYDPEIERYGGDKLILEAENLFFADSSLISNLIELKRWKKIDLD
                     EEVLGVINVISIFEGLGFTFEKTLNWLNDSLNYKEYLVEFREKRSILLKVANSHEEWKS
                     LREEPNGLTIYNLFLKRNYYLEKYSREIEEEKSKGKLTNDYDDIVGSVIHMSLNRLIGV
                     NREKEKKIMALARHTLHNLRYLRRKQ"
     aSDomain        complement(15684..15974)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_COE07_RS24900_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.20E-15"
                     /identifier="RREFam001.1"
                     /label="COE07_RS24900"
                     /locus_tag="COE07_RS24900"
                     /protein_end="268"
                     /protein_start="171"
                     /score="48.1"
                     /tool="antismash"
                     /translation="ITTNTSAYKNGNRLKIPYHTGYGQQLTQENAFVINYHSISYTPVV
                     KQVLEIAKERLVFKDLIKEVSNLYPDTSKAIIYKFVKQLLNEEFLISELRPP"
     gene            16942..17100
                     /locus_tag="COE07_RS24905"
                     /old_locus_tag="COE07_24910"
     CDS             16942..17100
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gallidermin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002498697.1"
                     /locus_tag="COE07_RS24905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24910"
                     /product="gallidermin family lantibiotic"
                     /protein_id="WP_088233001.1"
                     /sec_met_domain="Gallidermin (E-value: 1.2e-08, bitscore:
                     26.8, seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENNKLFDLDVQVSSNLEEQGGVEPRSGIICTPGTCQTLCRITEN
                     WCSLKCS"
     CDS_motif       16942..17019
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MENNKLFDLDVQVSSNLEEQGGVEPR"
                     /locus_tag="COE07_RS24905_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       17020..17100
                     /prepeptide="core"
                     /locus_tag="COE07_RS24905_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="9.40"
                     /molecular_weight="2692.2"
                     /monoisotopic_mass="2690.3"
                     /core_sequence="SGIICTPGTCQTLCRITENWCSLKCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MENNKLFDLDVQVSSNLEEQGGVEPR"
                     /leader_location="[16941:17019](+)"
                     /alternative_weights="2710.2"
                     /alternative_weights="2728.2"
     gene            17459..18184
                     /locus_tag="COE07_RS24910"
                     /old_locus_tag="COE07_24915"
     CDS             17459..18184
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686783.1"
                     /locus_tag="COE07_RS24910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24915"
                     /product="response regulator transcription factor"
                     /protein_id="WP_140417514.1"
                     /transl_table=11
                     /translation="MMNYSLLLVDDEKGLLDVLELALRKDGFQNIHTATTGVKALNKIK
                     EHSFDLIILDIMLPDIDGLEVCRQMRTLINAPIIFLTAKGTDMDKIMGLTIGGDDYITK
                     PFNSLEVIARVKANLRRQEFIANKPKNSEEKRFNLNNNVQVLEESGQILVGKTHIECPA
                     KEFELLIFLCNHPNRIFSVRQLYQQVWGDFYIGDEKTVVIHISRLRKKIEADPKKPSIL
                     VNVRGLGYKLILKNEEQQN"
     gene            18181..19272
                     /locus_tag="COE07_RS24915"
                     /old_locus_tag="COE07_24920"
     CDS             18181..19272
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="COE07_RS24915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24920"
                     /product="sensor histidine kinase KdpD"
                     /protein_id="WP_088232999.1"
                     /transl_table=11
                     /translation="MKILFRFIFHFTRVLGLLAFFMLFIYIILAQLLTNFVISTPYFHI
                     YAAIIFGIAFVIFAGLYSWYVIQPMFYLISWIKGLSQGNLERPYKKTYMPYLKKVMPKW
                     LRKTTPYFEELESHVEKLAHTLEQNQKLQQQLDQSKKEWLSGVSHDLKTPLSYLKAYSS
                     LLLSSDYKWSEEEKSNSLKIIYEKSLHIESLIDDMNLLFQSENGDLIVSLKDVDIIDFI
                     ENIVIDMANSPLAEGYNLSFETNIYSLHMKIDKKLMNRALSNLILNALVHNPPGTNISI
                     RISYNEHLNIYIKDNGIGMDEDTLEHLFEKYYRNSKFNRSHSSGLGMSIAQSFIVSQQG
                     KISVKSKINEGTLIKISLQDTNN"
     gene            complement(19388..>19611)
                     /locus_tag="COE07_RS24920"
                     /old_locus_tag="COE07_24925"
                     /pseudo=""
     CDS             complement(19388..>19611)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611647.1"
                     /locus_tag="COE07_RS24920"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="COE07_24925"
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="HHIGEEYKDIARKIS"
     gene            19803..20717
                     /locus_tag="COE07_RS24925"
                     /old_locus_tag="COE07_24930"
     CDS             19803..20717
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426675.1"
                     /locus_tag="COE07_RS24925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24930"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_088232998.1"
                     /transl_table=11
                     /translation="MNEYVIKTRNLTKKHGKINSVNNLNLEVPEGSIYGFLGPNGAGKT
                     TTIKMLLGLIKPSNGKIEIFNSDLLKNRSSILSKVGSLVESPSYYGHLSGYKNLEVIAT
                     MLDIKKSRIDEVLKLVRLTKEAQKPVKHYSLGMKQRLGIASALIGEPQLLILDEPTNGL
                     DPSGIQEIRELIIEMPKRFGITVMVSSHLLSEINAMATHVGIINEGNLVFQNKLEVLQD
                     KNKSQLYLEVGNPELAYAQLKNQGWEVDNKSNGLLVNSISRKDIAKIVESLVLEKNLIY
                     KVNEQKRSLEDIFLNLTGKGQSL"
     gene            20714..21430
                     /locus_tag="COE07_RS24930"
                     /old_locus_tag="COE07_24935"
     CDS             20714..21430
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="COE07_RS24930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24935"
                     /product="ABC transporter permease"
                     /protein_id="WP_088232997.1"
                     /transl_table=11
                     /translation="MISHLLLADWLKLKKIPVLGTILIGSMGLSIVVSVQSYFWSDKVS
                     ESKGIFIVAILNLFLHFTLMVIATLLSSIIAGNEHDSNSWKKIFSLPISKIQIFFSKTI
                     LVISLLAITSLLILLGSILIWSAFAGFDQIIWTLLLKQIAFSFLASLPTIAIQLWLSLS
                     IKNQAIPILIGVIGAVLSLFLARSSSVMLNFLPWSYPPLSTPLLPYSINWVWKGLLLGV
                     LIFILGAVKFSKQEAH"
     gene            21449..22174
                     /locus_tag="COE07_RS24935"
                     /old_locus_tag="COE07_24940"
     CDS             21449..22174
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="COE07_RS24935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24940"
                     /product="ABC transporter permease"
                     /protein_id="WP_088232996.1"
                     /transl_table=11
                     /translation="MFKRSLNSEKIKIQWYFFFLLIICETLMNSFISFIALGQDFSLNW
                     NSYYTYAANFHSMFFFPLLAGLFTTLLYRYEHNNNSWKNILTATIPKHYIYLSKIIWIF
                     LFLVITQLFFFLSYFIVGQILGVEGSLPLFSIFKSLVGGIIAIIPLLALQSWISIYIRN
                     FGASLVIVLGLIIPNLLLTGMHSNLGSWFPSTIPFYTMMPQGTQFSPRVDLFSLYIIVA
                     ITSTIYILGGSLSFRKREW"
     gene            22208..23113
                     /locus_tag="COE07_RS24940"
                     /old_locus_tag="COE07_24945"
     CDS             22208..23113
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="COE07_RS24940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24945"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_088232995.1"
                     /transl_table=11
                     /translation="MVTKNVIETYNLSKKYDKKIIIDQINLQVPQGSIFGLLGPNGAGK
                     TTLIKMLLGLSTPSSGEIKLFGESIQKNKIPLLGKIGAFIDTPSAFEHLNGVENLKYIC
                     KLRGLSYKQIDKSLKSVGLKDVGKSKVKHYSLGMKQRLGIATALLDSPSLLVLDEPTNG
                     LDPNGILEIRNLIQRLQNTGHTVFISSHQLSEIEQIATHIAIIESGNLRFQGTMNELMR
                     NNSTIISIHSDDTEECIHLLKSMSYQVSINKHLIEVRGSESDIPIITNLMLSNRVSLKG
                     INIRKQTLETSYFSKLKNIN"
     gene            23134..23817
                     /locus_tag="COE07_RS28655"
                     /old_locus_tag="COE07_24950"
     CDS             23134..23817
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="COE07_RS28655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24950"
                     /product="ABC transporter permease"
                     /protein_id="WP_088232994.1"
                     /transl_table=11
                     /translation="MLSIRLLHAELIKAKRTSVIYLAIVIPIIYSLLTLFILFFEQQKE
                     SFHLLPDFGWLYMFLPLGLTILTSLSSNVFYSNNMWKIIMIQPISRVSFYINHLLFIKL
                     LILTGCIVLSICSIFINIILFQETPLPWNSIISSCLISWVCSMPVISFQVLIGIKFKSI
                     AASLSIGIAGFFFSLISYYQASFLGMWHYPLSTIEGNNSYLIILSIFLSCFFTVIGVIS
                     LLKTE"
     gene            complement(<24211..>24384)
                     /locus_tag="COE07_RS28660"
                     /old_locus_tag="COE07_24955"
                     /pseudo=""
     CDS             complement(<24211..24384)
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_097948914.1"
                     /locus_tag="COE07_RS28660"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="COE07_24955"
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHSRKGNCHDNACVESFFSHFKSEMFYLNYYQTKEELTQAIETYI
                     YHYNYKRFQKRLN"
     misc_feature    complement(24956..24973)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     misc_feature    25153..25171
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.4"
                     /tool="antismash"
     gene            25155..25661
                     /locus_tag="COE07_RS24960"
                     /old_locus_tag="COE07_24965"
     CDS             25155..25661
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012009012.1"
                     /locus_tag="COE07_RS24960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_24965"
                     /product="GrpB family protein"
                     /protein_id="WP_071744104.1"
                     /transl_table=11
                     /translation="MLGLPKGEVFLVPWTEEWNKNFLSEKEKIQDKIGEYIMNIHHIGS
                     TSVKHLSAKPIIDIAIEIKDFKDGANTSSPLEKLGYSYRGTNILPDRHYFSKGEPRTHQ
                     IHMHQCGNKHLLEQLKFRDYLRDNDEARIEYERLKLNLAKLNKNNRQKYTEEKTTFIRT
                     ILGKI"
     gene            <25781..25894
                     /locus_tag="COE07_RS28495"
                     /pseudo=""
     CDS             <25781..25894
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002029165.1"
                     /locus_tag="COE07_RS28495"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="NIISGRCDNCGNTSFKSSVKDFIFLRECRQCGMKEII"
ORIGIN
        1 gtaggataga tttcaaacct gtagttcaat ttcattatgc cgtcacctcc gaatgtttgt
       61 tctaataact ctattataaa caaattttac gatgctatac cactcagaag tacttttgtt
      121 aggtcgggcc attcatctcc cacctacgct gtgcttagag gaaggagatg aatggctgaa
      181 gttcgttaaa agagcagtaa aagtaaaaaa atgtaagggt taaaatatta attttacttc
      241 gaacacccca aattcatcaa aatgaaaatt tatagccata tcatgtccct ttccatcaaa
      301 acatgaaaca aaaatgacat tatgtaactc tttttactaa ctcgaaattt ttttctaaaa
      361 atgcttaaag cttgatatat aagcttttct actacaccta tacaattcgt tatgaaaatt
      421 tatagctata tgatgtcccc ttttttcaga agaaaccccc ataaaccttt ttatattaag
      481 actttacatg tttataaccc tattttcatg tatttatgca acatgaaaat ccatagctgt
      541 atgatgtccc cttttttacc caaacatgaa aactatccta gccacttcat gttccttttg
      601 taattataaa attacagata aaccccatta acatcactat ttaaaagggt tcatctgttt
      661 aattcacaat tataaacatg aaaatccata gccatatcat gtccctttta tttttttgaa
      721 aatcgatata accgttgatt taatcatgtt tacaaggttt ttttgctatt tcacttcttt
      781 tctagcaata tgaaaatcca tagccatatc atgtccataa aaaaatttcc tggaatcctg
      841 aaaccccttg atacacaagg gattaaaggg cgtttcatct ttttgttttt tctcttaaag
      901 ggacgcattt cagcaaattt cgatttggta taatcaaaat tggtatattt tatagtgttt
      961 tggcatttat ttctgaattt ataggtagga ggtgaaaaag atgggaaaat catttattat
     1021 tcgtaatcaa cgtagtctaa atggacaatc tacaaatgca gttttagtaa cactgaagtc
     1081 ttggcaaaaa cttgttgaaa ctttcgaaga gaaatactac agctataaag atacatacct
     1141 tgaggatatt gttaatcaaa tgacatatga ggagcgtatt gccgatgtgg atggcttcgt
     1201 agcacaggct aaaccatctt tttcacgtcg tacactatct gctatttcgg aaacaatggg
     1261 aagaaagcat aaattatatg gccttacaaa cgcagatttg gaagtcttct tatatctaca
     1321 taaaaaatgt tacacgaatg gagtcattcc aaatgtaaca atacatatga tgtgggaaga
     1381 ttacaaacta tataaagaag aatttgctta catacagcat tctcaattct atattgcatt
     1441 aaagaaatta agtatacata acattattac gattgaaaat gaattagatg gtcgatatac
     1501 aattaaatta actcatttta tgaatgaaga aactgaaaag gcgaatgcat atgtttatat
     1561 tagcccggtg gtatttacga aagctttctt tgagctatca gttgcatcta agaagctatt
     1621 cttagatatt gctatgcaac agcacagtga aactacacta aaacgttcct tagacaaaca
     1681 agatgaaaaa gggaataaaa ctcattttgg tgggatgtac cgctttttac ataaaaaata
     1741 tccacatcaa atccgcgcgg ttatgacaga attaacaact gcattaccat gtacagggac
     1801 tccactattt aaaatttgta aattacaaaa aggggttaag aataaaaaaa gatatacgac
     1861 tctatatcta tccttacata cggatttctt atgtgcaaaa gaaacaggag aagtacagta
     1921 tcgcgatcca ttcacaccaa agcttactta tgctcgtaaa gctcgtttta tcgaatccgt
     1981 actacaagaa atgaatattg gtgaatttac acaagacatg aacaagttta tccatgtact
     2041 taaatataca tgccatcgac aaattcgaag cgtaattcat agcttacgtg acatgataga
     2101 tcgtaatgaa gaatatccaa gcaaattagt atatacactg aaaaaattat taaatcaaac
     2161 atcacaatat caaattcttg ataccgcagc taaagagggt atttatcctc tgattacaca
     2221 acatgttcca aaagaacaaa aagaacaagc tgtatttgat ttcggattgc atttctctat
     2281 gtactctctg agaaacatca aaaagttgtt ccgcaaaacg tatgagttac taaactacaa
     2341 atttgctgta cctgttacag aggaatctta tcaccgcaac tatctaaagt atcaagaaga
     2401 aacgttgttt agaaagtacg cttatgaaca aggtacaaac ctaaacgctt atatggcttt
     2461 agaaatagaa atacgtgaac tcttaaaggt aagaggacat aaagaacgct ctattcctag
     2521 tgatgttcgg gaattgttca ttgagaagat agatagatta ccgaaagaaa agcttcgcgt
     2581 tattgaagta ccagataact ttaatttaat tacatttatg cgtgcctttg aacagttaat
     2641 acgcgctggt atccccgtaa caacggctga gcaagtactg acagcaatga aaacgaacta
     2701 atcataatca gctctctatt tttgaaaaaa attcaagata gagggctatt cgtgttgata
     2761 cgtttattta aaagaatttt actcattctt cacaataagt aactttactc gattctattc
     2821 aaaatagagt ctttttttat gcaatcatat acaaaaatag tatagtacct atctacattt
     2881 ccacacatac ttccataaaa acatgttata agctgtctat atacattcaa atatctacaa
     2941 gaaatcataa gaaaaaaatt aattttcgtg gataagtaga taaataacac ataatgtgaa
     3001 taatttagtg ccattatcat tgatataaat ggcttatatg ccttcatcta tcaaaaatca
     3061 tcaatattaa tgtgagttat gtgtgaaatt aggatactgt tgattaaata acacataatg
     3121 tgaatctttt gtgggtaact ataataagat tgtggagatt cattgaattg atatgaaatt
     3181 ttacgattga ataaatatgt ttaataatgt atcaaattgt ttcatttttt atgtaggaat
     3241 actaaattcc atttatgatt atttgtagat tttaaaccat aataatacct aattttccat
     3301 tgttaaattc tactttttat gattttttac gctatgaaat gttaagaggc tttgttagag
     3361 taaggatata cgtacatttg ccagtcctat ataagtttta tctttatatt tttaatatat
     3421 ataagatata tatttatatt agattttatt aactactctt caattacatt gttattaaaa
     3481 tgattgaaaa gattaattta caattttaaa ttttattttc gaaccactta aaaaaaatca
     3541 tacaatcaaa aaaaagagca gcatattacc aacatgtgct cttcttttga taactgctac
     3601 cgtcaagtgg tggctatcaa ttatcattta tttttacgaa aaccattctt tttctgcttg
     3661 tgacggcgta aagaaagggt cgttttcttg ttattagcac agtttcaaag aatttaagat
     3721 ttttgtcgaa cgtcattcct attttggaat gacgtatttt tttaggaaca aattcgaaaa
     3781 tccgtatcat tatcatatgt atttagtgta tctagaattc tatatggatg gtgaagacat
     3841 atgagtcaat atcaaatgct gtatagtaca ccttatctat attcttctcg aacattgaat
     3901 caaatgtaca aagctaataa gaatgaagaa aacatatgcg ctatacaaga gcatatgtta
     3961 cgtcacgaag tatacctgaa ccaacaatac cgaggttact attatttaag tcaaaagatt
     4021 gaagaggagt tatacggcga agaacatgca ttgtcatgga atgagctact ggatgattat
     4081 caactttata gagatcgtaa ggggaattta tctatcaaac cgaaaggatg agataaacat
     4141 gacaatcatt ggagagctag ggattgtata tggcgtgacc ggagcttcag ttttaggagt
     4201 aaaattgctg aagaagaaag ggctttatct tccaggttgg ttgctacgtg caggtcttaa
     4261 atgcttgttg attgggagtg tttggtacgt tctaatggat atactagatg tgtttctacg
     4321 ttagtattac atctggtagt tgaaagtgat tataatagcg catcttaaac agctttttat
     4381 aggcttccat acaggctcaa ctaccttaag gaggtatgga gagaatgttg tcgcttttat
     4441 taattccagc aacctttata actgtagctt atttttatca aagtaatgga atgagtgata
     4501 agaaaaaaat tgcaacgttt tttgaaattg caaagatatg tgttcaacat aaaggtgaat
     4561 tacaataccc catttttata aaagaaatga aagatgatat aagtatgaat tatgtttaca
     4621 agttaccact tggtgtacct agtcaactta tccaaaagtt agctgaagta ttagaagaag
     4681 gtctatataa acctgttaaa atatcgtttc accaaagaga gcttcatatt cgagtattta
     4741 gccaacaaat acctgaaatg tggaattggt ctaaggatct attaaaagag catacatgga
     4801 gcgttatggt ggggaaagcg ttagataaat atgtatatca tgactttgag aaaacacctc
     4861 atatgtgtgt aagtggaatg actcgttttg gaaagacagt attcttaaaa aatgtgatga
     4921 ctagtttaat tttgcaacaa tctcaacacg ttaatttttt tattatcgat ctgaaagaag
     4981 ggttagaatt tagtccttac aaagagctat cccaagttgt agaagtagct gaaaatccga
     5041 aacaggcgtt agaaatgttg gctaaagtac gtgagaaaat ggtcaaacaa attgaagtaa
     5101 tgaagaagtc ctactttact aatatcatag atacatccat aaaagagcga tgtttcatca
     5161 tagtagatga aggagcaaat ctttgtccta cacaaggatt acctaaaaaa caacgtgatg
     5221 tattattttt gtgccaagag atgttatctg aaatcgcaag aatcggaggt ggtttaggat
     5281 tccggctcat attttgtacg caatatccaa cctctgatac attgccaaga cagatcaaac
     5341 aaaatgctga tgcgaaaata ggctttcgat taccaacgac ggtcgcttca caagttgctt
     5401 tggatgaatc agggttagag gatttgcctt ctcttccagg aagagcattg tttaaaacag
     5461 atcgtacaga ggaaatccag gtaccttatt taaaggatac agatatgtag gagttgctaa
     5521 agcaatataa ggtggtgaag caacatgagg catcaaacac tcaaacagaa agcgagacaa
     5581 atcgagattt tatccacttt gggtaagtta gattttttaa ctaggaggca actacaagct
     5641 atccattgtc tagggagcat tcgaaatgca aatcgtgtat taaaggatat gccctcgtat
     5701 tttcacatta caaaaatggc tcgtgaactc gtatattatt taaataaaaa gggacgggat
     5761 ttattaggca ttacaaaaga agtaaagaaa agtagccaat tacagcacat attaatgcaa
     5821 aacgagagtt ggatgtggct tggatttcca gaatggaaaa cagaaagatc tatcgatttt
     5881 tcaatcaatg gtcaacggta tgagattatt cctgacgcca cgtattttga ggataatgta
     5941 ccccattttg ttgaaataga tcgtatgcaa catatgaagg caaatgaaca taaaatacag
     6001 ttatatggcc atataacaga tatctataaa agacagaatg ctattgttcc ggtaattaac
     6061 tttttcacat tatcagacta tcggcaatcc aaattagaac aatatgctac aaaacaaaat
     6121 gtgtttatga gaacgttcgt gatggaccac atattctagg aatcttaaat attgatatcc
     6181 caaaaatcat gataatcaat gcggttatca aattttctta gtgttttaat gattttagtt
     6241 gcggatgtta aagtgggaac acgatccttt ttattcgcta aatcacttat taatgattta
     6301 cttaatccag ttttttgcac taaccactgt tgtttaattc ctctacgatc taaatagtca
     6361 ccaaatggag ttcttttttt tcctagacca aacataagga attcctccta aataaagaat
     6421 atcgtactta tagcttgtac aatattccat aaaactaaac ctttgttcat aaatatggaa
     6481 ttataatttg aaacaaagca tagaataata taaataaaat caaaaaatat ggaataattt
     6541 tgaggaatct agcattcata gtaatagcta caagttgctg atacactatc ctaatggcaa
     6601 cttgttgcaa agtgcattct tacaaaataa aaagcttaaa tccattggta cacaagggtt
     6661 taggcttttc ttaattcatg gagtaaagaa aacgagttta ataaattaag agatactata
     6721 ttgttcagtg gtcgaatatt gaagaaatat atgtatgtaa tttcacgtac cataatgata
     6781 ataaataaat attttctaaa tggttatata acgcaaggca ataggtttgt aacgagaata
     6841 aacgttctgt ttttggaggg taaaacgatg tttgattact caaaatggat aaatcaaatg
     6901 attttttgcc agttatgcat gtgttatgag gggtttagat ccactgaaag taaaattagc
     6961 tgtcgttggg gatatggata gaaacgggtc tattgtgttg gctgcgactc ctgagctgaa
     7021 aaaattaggg atttctacag caaccagatt atacgaaata ccaagagatc caaatataat
     7081 tgtggtaaat gcaacaatga gaagatatgt tgaaatctca gattagatca cagaaagtta
     7141 cacgaagtat gtagcattag aggatctaca cgtttactca gtagatgagt gctttctagc
     7201 catgcaacaa acagctcatc ttttcggacg tgatccaatg ataattgcta aaaggatcca
     7261 aagagaaata tatgacacaa ctggcataac agcatctatt ggaattggac cagatttgtt
     7321 tctttaaaaa attgctctag acgtggaaat taaacattca aactctagga ttgctatgtg
     7381 gacattcgag aatgtttcta aaaagttata gggaatcgga acggctagtg aagaggtgtt
     7441 gcatggaatg ggactatttt ccttgaagga tgttgcaaaa acacctaaag agcttctaat
     7501 aaagcgattt ggcaaagtaa aaggtgaaga gtcatatcac ttctcatatg gtattgatga
     7561 gagctggatt gctaataaat acattctaaa aagcatttct attacaaaag ggcaaatatc
     7621 attagaagac tgttttatcc acaacaaatt aaaaatgctt cttctagaac aaatagaaga
     7681 aacctgtttt cgcttacgat tttttgccat gatatataat tattatagta attttcgtat
     7741 ttcttctgta ctgagaccag tgaattttgc aataacttct aatggcattc catttttatg
     7801 cataccacga attaattggg ttttcccttg tttaatacct tcctctcgtg catgagctat
     7861 tttttttagc ttgttcatct agaagtattt tctcacgagc ttcataaccg cttcaaaagg
     7921 tatttatttt atagaagtac ttcaaatatg aagtttttaa tgttttgaag cgatgttttt
     7981 catagatatg tatctacatc aaaaggtgta ccttttgaag cggtgatgcg taaaattgta
     8041 cacgttacaa atagttgcag ttttagtgaa agtattgaaa aatgcatctt gtttattcaa
     8101 aataggaaag aacactccca cttcaaaaaa acacagaatt gttaggtggt gagtagttcg
     8161 attgtatctt taatagggaa atgaaaattg ggggagaaaa atattaatat tttatagttt
     8221 atgctttttt caaactttgc aacagaacca cccagcgcat aatagttgtt ggatgaacta
     8281 aaacaccaca ttctttcaaa atttcagaga catcgcgata acttaaagaa aaacgacaat
     8341 agtagccaac ggctaccaaa ataatatctt ttttgaattg cttcccttta aaatatctca
     8401 tttatgattc ccctcactct gttttgcaaa agtttagctt agttttaaac actttgcaat
     8461 agaaccgcaa tttaaatcaa aaacgaataa gttatatatg atagatttaa aaaatagaaa
     8521 taatgattaa aactaatttt ttcaaaaaag taatttatag tgtcgagaag aaactagata
     8581 aaaaatttat aaacagaagg gaagaggaag gtatgcaaaa agatcttata aaagatggat
     8641 tattaactgg tagttgccca gaaaaatatg aaaatggagt ggattatcac atttttcaag
     8701 gagaaacatc aatttatctc aaatctaaag aaaatgttac tcataaggaa tttggaactt
     8761 taatgtgcac aatcaatgct gatcgatatc gtggaaaacg attacgttta actgctgtta
     8821 taaaaacaga agatgtaaag gagcgggctg gattatggat ggggattacg ggggggaatg
     8881 cagaactgct tgctatggat aatatgaaaa atcgtccaat aaaacatacg gaaaattgga
     8941 agcctcattc tatcatattg gatgtagaag aaaacgcggt tgagattgcc actggtattt
     9001 tattgtttgg agaaggttgt atatgggtta ctcatttaca gttggaagaa ctagataaaa
     9061 agatgccttt agtaaatttg aaaacaaatg attgtgaatg tttacctata gaacccataa
     9121 acttgcaatt tgaagagtta gaggagcaag aaaagaaaga ataatagata tttattaatt
     9181 cattcattca tgatatggga gaaaacaatg ttatgaatta atgaattttt gaggggggtt
     9241 ctattgaaaa aagatggtta atttttaatg gtgatccata tattgaagaa gaatagatta
     9301 tgtattaggg gctttctttt tttttaccag gtttattaaa attggtaagt gttaaggtgc
     9361 agtattatag ttagaaatcc aaaaggttaa ataattctat ttaaagtcta tagtgttacg
     9421 cagaaattca tcttaattta catagcacta tagactcttc tcatgaggta tcatctatga
     9481 ctcaaaaaag tatcacttat aaaagttgat ttatctctta gcgtacggaa ttcgtgtttt
     9541 gttggtgcta cgccaattac atgtaagcct gttatccctt tgtatttaaa gactttatca
     9601 tttctaatac aattgtattc tgtaagctgc tatttcattg tgtaagcgaa aataagaagc
     9661 cgtttttgtg aatacatttt taaaaatgct gaaaagggaa tgagagatcc cattaaatct
     9721 ctcatttctc tttcgttaaa taatattttt gtataaatgt agatattgat ttgaaataaa
     9781 gtttaactgt ttataacaaa gtcgtaccgt ttaaaacaaa gtttaaccgt tttgaaaaaa
     9841 gtttgattaa aatacaacct ttatttcaaa aatacaactg aaaaagtcta tttcacaata
     9901 aaaagaagct gattacctac tgtatgtaga tgaccagctt cttatagcca caatgcaaat
     9961 aaattcatat tttaatttga tgttaattat attaattgtt ttaatttaat aaaaacaccg
    10021 agtcccaatc tggtctctct gtttgaattg tactaagtag agataagaca attccagtcg
    10081 tgccttctaa tagacctact tttgttacat agcgtatttg gttattttca tgtatacaat
    10141 cgtagtatcc taggggagcg gttgaatcat ataaggaaat tacctcttcc acaagttcat
    10201 ctcttaactt ttttaattct ttaactcctg tatctaccca catacattgt gtcatgtata
    10261 agagacctgc aataccatga cagaacgtag gagagtcaag caatcttgta ctagatggtc
    10321 ttttaaaagt tgctatataa gattctatag ctttttcttt ccaatggtct ttacctaaag
    10381 catctgctgc taaccataaa gagcgagcaa cacccggtga cccgtaacac catccatctc
    10441 tatgtgtcga tttacctttt aatactccat ttacatgttc ttcccaacta atacaatttg
    10501 gccaataaac tccatactca tcatatgcag tccactttaa taaccattta gcaatatttt
    10561 ctatagcttg tacttgacca ggaacttcaa tccccttttt ttgggttaaa gaaagtaatg
    10621 ctaaaactcc aggtatacca tgtgataatc cacaattaaa atttccttga gggtaactaa
    10681 atttatcaga atctaataat agcttatcca caggtatata ccatccagga acatattgtc
    10741 catttatata cttatgctca ctaactttaa ctagatattc taaaacttct aacaatgctt
    10801 gttttatctt aggattctct tgaaactcta acagatacct tccaatacca ctccaccctt
    10861 gaatggcatc ataatttttc attgataccc catcattaat ttgagcaaat gattcctcta
    10921 acagattcga ataattattt aggaaaaagg tatgcaaggt atttatcata ttttgatatc
    10981 tggtgccacc tttagataac ccatttgccc ccattataat gccagatatt cctccccata
    11041 gcgaaagact tgtgattgtg tcttcattaa gcgatttttg aatagccttc atatattcgt
    11101 ggcctgtaat atcccagttc atttctggaa aacttctatc tagctcaccc attaataagc
    11161 aaattccagg atagccatgt gagaggctta gatcttgcca aggcaataac tcatgatttt
    11221 ctactctaac aatatttttt ttatctaatc catgttcttt tgatttttta ggatcttgta
    11281 ataatctaga taatgctaaa gttaatgtag aaatcttata tgataaattc tcatcttcaa
    11341 taggcttcca attattctta agagttgttt ttttcattta tttgctcctt ttaatgatta
    11401 gatactaaat tttcttcttt agcgaaattt gacatctgaa gtctatataa cttcgcatat
    11461 tgtccatcta atttcatcaa ttcatgatga gtacctgatt ctacaattct tccattatcc
    11521 attacgataa ttttatctgc aaaagataca gaggaaaaac gatgggatat gaaaattcct
    11581 attttatttt cgactagttt tctgaattta tcaaacactt ctatttcagc ttcaggatct
    11641 aaaaaagaac taggctcatc cagaatatat acatctgcgt ttctcataaa agccctagcc
    11701 acagcaactc tttgccattg ccctcccgac agttgatgtc catctttgaa taacttacca
    11761 agttgtgtat ctagtttaga tggtaattgg tttactaaat cttttatacc tgctctctca
    11821 gctgccttta aaacctcatc tgaattgttc acattcataa gatttccaaa tccaatgttt
    11881 tctctaacag acatttcgta atgaacaaaa tcttgaaata cgacccctat tttttgtaaa
    11941 aactgatctt ctggataaga tactattgat ttcccattaa ttagaatatc tccctgataa
    12001 tcttgataaa gctgagccat taatttaact agcgttgact taccagagcc atttttaccg
    12061 acaatagcta cagtttctcc cctattaagt tctaagtcaa ttgtatctag agctagcttc
    12121 ttactgtttg ggtaacagaa acttaaattt cttagcctta tttgttctat actatccaag
    12181 gagttgtttt ctattatttc tttactgtgt aagcttcttg ccaatttatc gctggaatcg
    12241 agacttagaa aagtaaataa ctgttgcata tataagttat tttgacaaaa tgacaagata
    12301 tattgtactg caccttgagc atttgcctgt gtcatcataa cagcctgtat catacccact
    12361 agttgaccta tattgatttg ttttgtatac gtatcatgca agattaaaaa tataacatac
    12421 gctactacta cttgattcaa taatttaaag aaaaaagaaa tgttagttct acgtctaaca
    12481 agagatttat tttcttgata gaacaaatta aatagttctc tatatcttgt taaaagatat
    12541 tgacctaatt tataaatttt aatttcttta aagctactat ctttagtaac aagaaatgtt
    12601 aaataccaag actgtctata tttaggcgct ctattatact gtaattggta ttcttgtttt
    12661 ccaatacgta ataatgaaat aaacgatgta atcggaacaa caattaataa tatagttgtt
    12721 gtccatctcc aagaaaggag aatagatgct gttgaaaaaa gcataataac gccactaatt
    12781 attgagagta tttccatgaa aatttgataa ggtctataat tagcttcgct ttgggatctt
    12841 tttagctgat cctgaacatc agcattttca aattccgtca gagataagtt aatggtcttt
    12901 tccataatta aaatattcac tctgttagat aataggcttt caaacaattt atggaagtaa
    12961 ttttttatca acgagataac ttcattcata aaacctatac ttattaacaa caaaaagtag
    13021 aatattacat cgtcaaaact attggttgct tgagccttta ttacactatt cactatattt
    13081 tgggtacata taagaattat tgctggagta attccctgta agccagtagt gattaatata
    13141 atgagtaaat aaaatttttg cgtcccccaa agtaggccaa atacttgagg ccaaaaacga
    13201 aaagaacgcc agacatttaa gatgcttaag gtttctaatg attccttatc tactttgctc
    13261 atttattgtt ttctccttag atatcttaag ttatggagtg tgtgccttgc taaagccata
    13321 attttctttt ctttttctct atttacacca attagacggt tcaggctcat atgaattaca
    13381 cttcccacta tgtcatcata atcattcgtt aacttccctt tacttttttc ctcttcgatt
    13441 tctctcgaat atttctcaag ataatagttt ctttttaaaa ataaattata aattgttaaa
    13501 ccattaggtt cttctcttaa acttttccat tcttcatgtg aattagctac tttaaggaga
    13561 atactccttt tttctcgaaa ttctactaga tattccttat aatttaagct gtcgtttagc
    13621 cagtttaatg ttttctcaaa agtgaaccct aggccttcaa atatacttat aacattaata
    13681 actcccaata cttcttcatc taaatcaatt tttttccaac gttttaattc gattaaattc
    13741 gaaattaagg aactatctgc aaaaaagaga ttttcagctt ctaaaattaa cttatctcct
    13801 ccataccttt caatctcagg gtcataagta tcaatggtta ggttagataa catgccttct
    13861 tctcttaatt gttgcgacca tttataaaaa gcaattaaac cttttgtttg tataagatga
    13921 gggtcaccct tgaatcgaat tcttaaatga tgcttaggat ctgcatacct tataaaaaac
    13981 catgaatcca accatccttc tttctgagca gaatgaacaa attccttcag ggatttacta
    14041 ataaactctt cttgccgttg acccattcca tacaatttca catagagcca ttcactccct
    14101 gggaatttta atctttcatc cccaataatg gttttattta tatcttctct aggagcatct
    14161 atcacattag ataagcgttc attatgcttt tttactaacg gaaaaacaca ttcaacaaga
    14221 tatgtcccct gttcactagt tacccagctg tccaaaatat catcatctac ttctatcaaa
    14281 cgaaggcttt gaccactagt cagtttcgta taatctttcc tgataatttc caaatgaaga
    14341 ggattatcta aatctagcag caatctatta tctccaactg taagaaaaac atacttagag
    14401 actttccatt tatctctcca tatgtttatt aaattattcc atttatgagt ttcattaatg
    14461 tcctgtttat caaatgtatc ctgattaatt ttccattcag caggagagat tattatattt
    14521 cctgatttaa ttctcggtag tacaggtaaa tcccctaaat ttccccaatc aaaagacatc
    14581 catctctttc ttccctctaa tcctatctca gctaagaaac gacaaacatt tggtgcagta
    14641 aggtagttaa gcatatgatt atttgtcggg ataatttttt tatttaagga tttagatttt
    14701 aaataaaagc tatcaaaagt agcgccgact actatatcag acaaaggtat tgtatgattt
    14761 gcccccttag atgaatttgt tccaataact atctcatagg gacgaatatt ctcggttaac
    14821 gcaacattag aatttctacc agctggaggc aaatacacta tttcagcaaa aattgcgtct
    14881 tcttcaattt cttgttccaa attatgaata gaattcattt tttcagttac ttcagtatca
    14941 aagagatcaa taaatctccc aaatgtcttt ccagcgcctt cagatccagg attagggctt
    15001 aatatcattt tataatcgcc tttatttagc gcatctttac ttctggaaag aatagagaag
    15061 tataattcca tggaaagagg agccttttca tcatctactt cattatcttc aatatctttt
    15121 agcctattat gatcaatctc aatttccatt tcccctttat taaccgcttc cataatccat
    15181 ttatttaaaa atttttcccg atttttttga aaatctgaaa ttggctcatt gtaactataa
    15241 gggctcttag gatatttata agtcgcaggt gctcctaatc caatatcttc atctagcaaa
    15301 tcaagtatag gaacctctct gtacggtcca tatttttcta aaaattcatt tcgatattga
    15361 ctcaaatgac taaatccgat aaccggagga gatagcttcc aaagtaattc tgctgctttt
    15421 tcaacatttt ctttaatctc atatgttaaa gtattgtttt tttctttaat tactaaatcg
    15481 acttgtaatg ggttcttaac ttgaacaata ctgttcattt tatgatttat taactttaat
    15541 aagttttcac ccgtaccaat agataacgcg ttatattgct ctatgtattc tttaatctca
    15601 actaattcag ttgtaaaatt ggaattctta tccaccctta aaagtatgtt tagaacatga
    15661 ttaaaaggat tcgtacacat gaacggtggg cgaagctcac ttattaaaaa ttcttcgttc
    15721 aataactgtt ttacaaattt gtatattata gctttgctag tatcaggata taagttactt
    15781 acttctttaa ttaaatcttt aaatactaat ctttctttag caatttcaag tacttgtttt
    15841 accacaggag tataactaat cgaatgataa ttgataacga aagcgttttc ttgggttaac
    15901 tgttgaccat aacctgtgtg ataaggtatt tttaaacgat ttccattttt gtaagctgaa
    15961 gtatttgtcg ttatataaag atcatccatt atttcttctg acttttctaa aacctcaacc
    16021 aattttaata accattccat gtctgctcta gcacgttttt taaactgatt aaccccttct
    16081 aaggatatgt tccctaagtt atgaaactta ccatgtgata cacctgaaaa aataccataa
    16141 ggagttggcc ttgtagtcat tctatttaaa taacgtgaaa atgagtcaat cgtttgtctt
    16201 ttctttttgt tattagtgct caaattaata ttgtctaatg aactatgtaa agcgttactt
    16261 gctacagcta ttgtttctcg aataactgga ttacttgaaa gttcttgtaa attttctatt
    16321 cccatttcat attgctctat atcttgcttt cctactaaat caaaacattc tttataaact
    16381 tcaataggca atagaggcgt tctaatcata aaaaaatcta atgcacaaaa aattgatgat
    16441 tctgtagtta aactcgtatt ttttaaatca tcttccttag tgatcatcta tctcactcct
    16501 cctacttgta attagtttta tctaattatc aaaataaaca aaaacccttc tcattataaa
    16561 cacttatgca aatgaatgta tagtatttct tgtaaattga tacattattt atcaattata
    16621 ccaaaataac tcaaaaattt ttcggataga ataatagcct ttgaagtgtt ttttgttttc
    16681 tttgtatata taacctttga agtgtttttg ttttctttat gtagatattt ttctctagaa
    16741 cgaaataaaa tttaaatttt actaacataa cataaaaata gaataaatta ataaatatac
    16801 catacattta cattttttca atatttttat attttttctt ctttttgtaa aaaaactata
    16861 tacaaactca aattttttat gtatattttt ttgtgaggtg catttcaaaa aataatcaca
    16921 gtcgagaatg gagaatttaa aatggaaaat aacaaattat tcgatttaga tgttcaagtt
    16981 agctcaaact tagaagaaca aggtggagta gaaccacgta gtggaattat ttgtactcca
    17041 ggtacttgtc aaacactttg ccgaattaca gaaaattggt gctctttaaa gtgtagttaa
    17101 ttaaaagatt aataatctta agaacaagct ctttttcggc caaaaaagag cttgttcttt
    17161 tacctcatat actaaataag gtaaaattcg tttgtgtata aagctgcgtg tatgtttata
    17221 aaagataaat ttttcaatat acaccacttt ctatagctaa caattaactt taactatgtt
    17281 cctacacgtt attatgccaa atgaaagtaa acacgaagta aataaaaact tatatttact
    17341 taactaatta aattgaatag aaatctgtat taaggtactt attaaaaaat aagtgctttt
    17401 tttgtttgtt cgatataata tcagtaggat atattattat ttttaggaaa gaaggggcat
    17461 tatgaattat tccttactat tagttgacga tgaaaaaggt ctattagatg tactagagtt
    17521 agcactaaga aaggatggtt ttcaaaatat acatacagct acaactgggg taaaagctct
    17581 aaataaaatt aaagagcact ctttcgatct tattatttta gacattatgc tacctgatat
    17641 agacggttta gaagtatgta gacaaatgag aactctaata aatgcaccta ttatatttct
    17701 aactgctaaa ggaactgaca tggataagat tatgggatta actattggag gcgacgatta
    17761 cataacaaag ccttttaatt ctttagaagt aattgcacga gtaaaagcaa acttaagaag
    17821 acaagagttt atagcaaata aaccaaaaaa ctctgaagaa aaaagattta acctaaacaa
    17881 taatgttcaa gtattggaag aatccggtca aattcttgtt ggtaaaaccc atattgaatg
    17941 tcctgctaaa gaatttgagc tcctaatttt tttatgtaac catcctaatc gtatatttag
    18001 cgttcgacaa ttatatcaac aagtttgggg ggatttttac attggtgatg aaaaaacagt
    18061 ggtgattcat atttctagat tgagaaagaa gatagaagca gatcctaaaa agccctctat
    18121 cttagtaaat gtgcggggat tgggttataa attaatatta aaaaatgagg agcaacagaa
    18181 ttgaaaatac tttttcgttt tatttttcac ttcactaggg tccttggttt attagcattc
    18241 tttatgctat ttatctatat tatattagct caactactaa ctaactttgt tatatcgacg
    18301 ccttattttc atatttatgc tgctataata tttggtattg cattcgtcat atttgcaggt
    18361 ttatatagtt ggtatgtaat acagcctatg ttttacttaa tttcctggat taagggtcta
    18421 tctcaaggga atctagaaag accctacaaa aaaacttata tgccttactt aaaaaaagtc
    18481 atgcctaaat ggttgagaaa gacaactcca tactttgaag agttggaaag tcatgtggaa
    18541 aaactagccc atactttaga gcagaaccaa aagttgcaac agcaattaga tcaatctaaa
    18601 aaagaatggt tatccggtgt atctcatgat ttaaagaccc cactttccta tcttaaagct
    18661 tactctagtt tattattatc atctgattac aaatggtcag aggaagaaaa gtcgaattca
    18721 ttaaaaataa tttatgaaaa atctctccat atagaatcac ttattgatga tatgaatctt
    18781 ttatttcaat ctgagaatgg agatttaatt gtttcattaa aggatgttga tatcatagat
    18841 ttcattgaaa atattgtaat tgatatggcc aacagccccc ttgcagaagg ttataatcta
    18901 agctttgaaa caaacattta ttctttacat atgaaaatag acaagaaact tatgaataga
    18961 gcattatcta accttatact aaatgcactc gttcataatc ctccagggac aaacatatca
    19021 attcgtattt cttacaatga gcaccttaat atatacataa aagataatgg aatcgggatg
    19081 gatgaagata ctttagaaca tttatttgaa aagtattata gaaattctaa attcaatcgt
    19141 tcccatagca gtggtttagg aatgagtatt gctcaatctt tcatcgtttc tcagcaaggt
    19201 aaaattagcg tcaaaagtaa aattaatgaa ggtacattaa tcaaaattag tttacaggat
    19261 actaataatt gattattagt atcctcagag tatttgggaa ttttttagag tttccaacac
    19321 tcattgaaaa ttgaattttc aatgagtgaa aaacacgaaa aaatgataga aataagaaaa
    19381 atagtcctca acctganntc aggttgagga ctattttttt catattatgg tgaggtaagt
    19441 ctgtatttgg acagaattta ttcctcggaa acgagcgtat cgatagctat gtagctcttt
    19501 agcatccgta aaactcagtt aaatggtaga acagcatact ttatatcgtt ttccttaaac
    19561 ttgttagctt atttttcttg ctatatcttt atattcttcc ccaatatgat ggtaacggaa
    19621 aaaccgcaca gtctagtctg ctgaattagg cttatattgg cgctacccta ttaacataaa
    19681 tatattcttg ttcagacaca aaataaacag gataccaata attaattatt agtatcctgt
    19741 tcgttttgtg tttaccttat gtttacttaa gtttagtaga atataagcga ggtgaaaaat
    19801 taatgaatga atatgtaatt aaaacaagaa acttaacaaa aaagcatgga aaaataaatt
    19861 cagttaacaa cttaaactta gaggtacctg aaggaagtat atacggattt ttaggaccta
    19921 atggagcagg taaaacaacc actattaaga tgctactggg tttaattaaa ccttctaatg
    19981 gcaaaataga aatttttaat agcgatttat taaagaatag atcctctatt ttatctaaag
    20041 ttggatctct agttgaatct ccttcatact atggacactt aagtggatac aaaaaccttg
    20101 aagtaatagc tactatgtta gacataaaaa aaagcagaat tgatgaagtg ctgaaattag
    20161 tacgcttaac taaggaagca cagaaacctg tcaaacatta ttccctgggt atgaaacagc
    20221 gattaggtat tgcctctgca ttaataggtg aaccacagtt gctaatatta gatgaaccaa
    20281 ctaatggtct agatccttca ggaatacagg aaataagaga attaattatt gaaatgccta
    20341 agcggtttgg tattacagtg atggtttcta gtcatttact aagtgaaatt aacgccatgg
    20401 ctacacatgt tgggattata aatgaaggca atttagtttt tcagaataaa ttagaagttt
    20461 tacaagataa aaataaatct caactttatc ttgaagtcgg taaccctgaa ttagcttatg
    20521 cacaattaaa aaatcaaggc tgggaagtag ataacaaatc taatggcctt cttgtaaact
    20581 ccattagccg taaagatatc gccaaaattg ttgaatcttt ggtattggag aagaatctta
    20641 tttataaagt taacgagcaa aaaagatcat tagaagatat ctttctaaac ttaaccggaa
    20701 aggggcaaag tttatgatat ctcacctttt attagcagat tggctaaaat taaagaagat
    20761 acctgtatta ggtactattt taattggaag tatgggctta agtatagtag tatctgttca
    20821 atcgtatttt tggagcgata aagtaagtga atcaaaaggc attttcatag ttgccatttt
    20881 aaatttattt ctccatttta ctctgatggt tatagccact cttttatcgt caattattgc
    20941 aggaaatgag cacgattcta atagctggaa aaaaatattt tcacttccaa tttctaaaat
    21001 ccagattttt tttagcaaaa ccatattagt aatttcttta ttagctatta caagcctttt
    21061 aatactgtta ggttctattt taatctggtc agcctttgca ggctttgatc aaataatttg
    21121 gactttactc ttgaaacaaa tagctttttc gtttttagct tctctaccta ctattgctat
    21181 tcaattatgg ttgtcgctaa gcattaaaaa tcaagccata cctattttaa ttggggtaat
    21241 tggagcagtt ttaagtttat tcttagcacg ttcttcttca gttatgctta atttcttacc
    21301 ttggtcatat cctccattat ccactccatt attaccctat tctataaatt gggtttggaa
    21361 aggattattg ttgggagtat taattttcat tttaggagca gtaaagtttt ctaaacaaga
    21421 agctcattaa gaaaaaggga gtcaataaat gtttaaacgc agcctaaatt cagaaaaaat
    21481 aaaaattcaa tggtattttt tctttctatt aatcatttgt gaaacattaa tgaatagctt
    21541 tatttctttt attgccttgg gtcaagactt ttcattaaat tggaatagtt attatactta
    21601 tgcagccaat ttccattcga tgtttttctt tcctttgtta gctggtttgt tcacgacctt
    21661 gttatatcgt tatgaacata ataataatag ttggaaaaat attttgaccg caactatacc
    21721 taaacattat atttatttat cgaaaataat atggattttt ttatttttag tgattactca
    21781 attgttcttc tttctaagtt attttattgt tggtcaaatt ttaggagtag aaggatcgtt
    21841 accgttattt tccatattta aaagtttagt tgggggtatt atagctatta ttcctttgtt
    21901 ggcattacaa tcctggattt ctatatatat tagaaacttt ggtgcctcct tagtaattgt
    21961 acttggattg ataattccta atttattatt aacaggaatg cactctaact taggtagctg
    22021 gtttccttct acaatacctt tttatactat gatgccacag ggcacacaat tttctcctag
    22081 agtagattta tttagccttt atataattgt tgctataact tcaaccattt atatattagg
    22141 tggctcactt tcttttcgga aaagagaatg gtaacaacct atcttttatt aaaaggagta
    22201 ataaaaaatg gtgactaaga atgttataga aacatataat ttatcaaaaa agtatgataa
    22261 aaaaattatt attgatcaaa taaatcttca agttccccaa ggaagtattt ttggattact
    22321 aggtccaaat ggtgcaggaa aaactactct cataaagatg ttattaggtc tttctactcc
    22381 tagcagtggg gaaattaaat tatttggaga atccatacaa aaaaataaga tacctttatt
    22441 aggtaagata ggagcattta tcgacactcc tagtgctttt gaacatttga atggtgtgga
    22501 aaatttaaag tatatttgta aattaagagg actttcatat aagcaaatag acaaatcttt
    22561 gaaatctgtg ggattaaaag acgtaggtaa aagtaaagtt aaacattatt ctttaggaat
    22621 gaaacaaaga cttggtattg ctactgcact tttagactcc ccttctctac ttgtgttaga
    22681 tgaaccaact aacggtttag atcctaatgg cattttagaa ataagaaatt taattcaacg
    22741 attacaaaat actggtcata cagtttttat ttctagtcac caactttcag agatagagca
    22801 aattgcaaca catattgcta ttatagaatc aggtaatttg cgttttcaag gaacaatgaa
    22861 cgaactaatg aggaataact ctacaattat ttctatacat tctgatgaca cagaagagtg
    22921 tattcacctt ttaaaatcca tgtcttatca agtgtcaatt aacaagcatc tgatagaggt
    22981 acggggatca gaatccgata tacccataat tacaaattta atgttatcta acagagtatc
    23041 tttaaaaggt ataaatattc gaaagcaaac actagaaaca tcatacttta gtaagttaaa
    23101 aaatattaac taaagaaggg acttaaatta ctgatgcttt caataagatt gttacatgca
    23161 gagctaatta aagcaaaacg tacttctgtc atttatttag ctatagttat tcctattata
    23221 tattctttac tcactttatt tattttattt tttgaacaac agaaagaaag ctttcacttg
    23281 ttacctgact ttggatggtt atacatgttt ttaccgttag gtctaaccat tttaacttct
    23341 ctatcttcaa acgtttttta ttctaataac atgtggaaaa taataatgat acaacctatt
    23401 tctcgagtta gcttctatat aaatcatcta ttgtttatta aacttcttat attaacagga
    23461 tgtatcgtac taagtatttg ttcaattttt ataaatataa tactgttcca agaaactcca
    23521 ttaccttgga acagtattat aagttcatgt ttaatctcat gggtttgcag tatgcctgta
    23581 atttcatttc aagtattaat aggaataaag tttaaatcaa ttgctgcttc tttaagtata
    23641 gggatagctg gatttttctt cagcttgatt tcttattatc aagcttcttt tttaggtatg
    23701 tggcattatc cattgagtac aatagaggga aacaattctt atcttataat acttagtatc
    23761 tttctaagtt gcttttttac cgtgattgga gtaatttcct tattaaaaac tgaataaaaa
    23821 taaatctaat taaaaaataa aatttataaa tcctcaataa aaatcagttc atctaaaacg
    23881 aaatatcgca aaaacataaa aaacctttaa attatgaact gaactgcatc ctataaatgt
    23941 tgctttaaaa taaagtttga tcaaattgat actaataacc ttgataaacg ctcatagaaa
    24001 agagcgtgtt ttaaaaaaag tttaatcaaa acacgctctt aatattttca gttggttcat
    24061 tctttggttc tggtgcaaaa actctaaagc tcttgcaagt aatctcctaa aattggatat
    24121 actgatagta ttacttggtt tccccccgtc aagtagataa ctgtaaaaag gcttaactat
    24181 cgagcgccga ttgaataccg aatctcgata gttaagcctt ttttgaaatc gtttgtagtt
    24241 gtaatgatag atgtatgttt caatagcttg agttagttct tcttttgttt gataataatt
    24301 aagataaaac atttcagatt taaaatgaga gaagaatgat tcaacgcaag cattgtcatg
    24361 gcagtttcct ttgcgggagt ggttgctgat ggttccctac acatctcttt tttgtgctgc
    24421 taggggtccc acacacatgc ctataaactt aagaatttta taatacccca aaaaaaaaat
    24481 tcgcattttc acctgaagat gtcaattttc tcattttggg gtatttgctt ttcttagctt
    24541 gatggcaatg tggtgaaacc ccttttattc aaaattagcg gattttcgat aaataattaa
    24601 tgagcttgct atataaatag agtcctatat taattagcaa gatctaatat ctaaaaagca
    24661 ctttagaatt accccaataa cagcggcctt ttcgagctta gttaaatgca tctatcctca
    24721 ctccttatca tttttcaaaa taaaaaagca tccactatgt gaacacttca tgttattatg
    24781 gttaagttat attaatttat attgatatgc aggtgaaata aatggaaaat aaagaaccta
    24841 aacaacctaa acaagaatac gatctaagta aaatatacac atataaagag ttccctgata
    24901 aaatttaaat agactaaact aataagagga tagtatgttc aatataagag catgctatcc
    24961 tctttctcgt atatattaga attattaaca tgatattgaa aatatagttt aatatgttta
    25021 caaaaagtta taagggagaa caacgttctc aatttcttct tcaactaacg ggcagagtat
    25081 taaaagagtc ttttaatatg gtataatgtt tcaactgttt taaaaacggt attagcgtta
    25141 aaagggggaa tacgatgtta ggcttgccaa aaggtgaggt attcttagtt ccttggacag
    25201 aggaatggaa taaaaatttt ttatcagaga aagaaaaaat acaagataaa ataggggaat
    25261 atataatgaa tattcaccac ataggaagta catcagtaaa acatttaagt gcaaaaccaa
    25321 ttattgacat agccatagaa atcaaagatt ttaaagatgg tgcaaatact tcctcacctt
    25381 tagagaagtt gggatattcg tatagaggaa caaatatttt gcctgataga cactatttta
    25441 gtaagggtga accaagaacc catcaaatcc acatgcatca atgtggaaat aaacatttac
    25501 ttgaacagct aaagttcaga gattacttga gagataatga tgaagcaaga attgaatatg
    25561 aacggctcaa acttaattta gcaaagttaa ataaaaataa tagacaaaaa tatacagaag
    25621 agaaaactac tttcattaga acaattttgg ggaaaattta atgggtattt tataaagtta
    25681 acaggagagt aagttaaaga aaaaagggca taacatattt tatatgacta atatgttatg
    25741 tccctttatt tatctatctt ttttcaattt aagtcttgat aacataatta gcggtcgctg
    25801 tgataattgc ggcaatacct cattcaaaag ttctgttaaa gatttcatct ttttaagaga
    25861 atgtcgtcaa tgcggtatga aggaaatcat atagccctat tcagggcttt tttctttgca
    25921 aaataaaaac acttggatgg atgctgtagt ttaattaatt acttttaaat caacgtctat
    25981 atcataataa attagtaaaa atatatgtat aggtaaatag agaagaatat agtattatta
    26041 cttattaatc agcatttata tcggtatata atttactatt tttcgaagaa tttatggttg
    26101 taatgaaata taatttccta atcaatctta tactagaaaa gtgtacattt cgaaacgctt
    26161 tacagacgta tccaggatta cttttatctt tagatatatg aaaataaaat attcgtaaag
    26221 ttataccttt ataaactaaa tgctttttac aactaataaa tcaatttttt ttgatttatc
    26281 agttgtaaaa gtaatgaaaa gtgtatatat tataaatatc aaaaaaattg atgaaaggaa
    26341 attaccatga aagaaattaa attgtacact caatcgactg cccaaacctt tgaaacgtat
    26401 gaaaagaagt ttaaagcatt ggcagatcaa aaaaggttac acgttttgta cgaattgtgt
    26461 cagcgtggag aaacttgtgt atgtgat
//
