LOCUS       NZ_NUOG01000005        26537 bp    DNA     linear   CON 31-JUL-2024
DEFINITION  Bacillus sp. AFS033286 AFS033286_82_A2_Contig8_140604, whole genome
            shotgun sequence.
ACCESSION   NZ_NUOG01000005
VERSION     NZ_NUOG01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus sp. AFS033286
  ORGANISM  Bacillus sp. AFS033286
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 30385)
  AUTHORS   Bleich,R.M., Grubbs,K.J., Santa Maria,K.C., Allen,S.E., Farag,S.,
            Shank,E.A. and Bowers,A.
  CONSRTM   Agbiome Team Llc
  TITLE     Large-scale bioinformatics analysis of Bacillus genomes uncovers
            conserved roles of natural products in bacterial physiology
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 30385)
  AUTHORS   Bleich,R.M., Grubbs,K.J., Santa Maria,K.C., Allen,S.E., Farag,S.,
            Shank,E.A. and Bowers,A.
  CONSRTM   Agbiome Team Llc
  TITLE     Direct Submission
  JOURNAL   Submitted (07-SEP-2017) Chemical Biology and Medicinal Chemistry,
            UNC Chapel Hill, 125 Mason Farm Rd., Chapel Hill, NC 17599, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Assembly Cell v. 4.2.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 78.73x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002583065.1-RS_2024_07_31
            Annotation Date                   :: 07/31/2024 14:02:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,319
            CDSs (total)                      :: 5,247
            Genes (coding)                    :: 4,997
            CDSs (with protein)               :: 4,997
            Genes (RNA)                       :: 72
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 250
            CDSs (without protein)            :: 250
            Pseudo Genes (ambiguous residues) :: 0 of 250
            Pseudo Genes (frameshifted)       :: 83 of 250
            Pseudo Genes (incomplete)         :: 197 of 250
            Pseudo Genes (internal stop)      :: 59 of 250
            Pseudo Genes (multiple problems)  :: 74 of 250
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:15:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3848
            Orig. end                         :: 30385
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NUOG01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26537
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="True"
                     /product="lassopeptide"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26537
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="lassopeptide"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..22725
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22725
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12725](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12725)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(79..372)
                     /locus_tag="COE07_RS01750"
                     /old_locus_tag="COE07_01750"
     CDS             complement(79..372)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000935903.1"
                     /locus_tag="COE07_RS01750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01750"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_088233259.1"
                     /transl_table=11
                     /translation="MLNYEKNAAVLKALAHPIRIKILKELITRGACNVTQIVDILGIPQ
                     STVSQHLSKMKSQKLIMSDRKGLQIYYSAQNKTINSIVEMLLDLKLLIVNKN"
     gene            complement(676..1383)
                     /locus_tag="COE07_RS01755"
                     /old_locus_tag="COE07_01755"
     CDS             complement(676..1383)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000598658.1"
                     /locus_tag="COE07_RS01755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01755"
                     /product="response regulator"
                     /protein_id="WP_088233258.1"
                     /transl_table=11
                     /translation="MIKVLILEDDPMVAMLNTHYLEQVGGFELVHAVKSVKAAIEVLEK
                     SQVDLVLLDIFMPEETGFELLMHIRNQEKEIDIMMISAVHDMGSIKKALQYGVVDYLIK
                     PFTFERFKEALTVYREKFTFMKEQPEISQSELDSLILQKEKRVPFDDKVLPKGLTKQTL
                     QLIWQKIESLNGRAFTTDEMAQLVGVSRVSIRKYVMFLTEIGVLENEIVYQNVGRPVSK
                     LRCIDQNKIDFYV"
     gene            complement(1385..2983)
                     /locus_tag="COE07_RS01760"
                     /old_locus_tag="COE07_01760"
     CDS             complement(1385..2983)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746351.1"
                     /locus_tag="COE07_RS01760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01760"
                     /product="sensor histidine kinase"
                     /protein_id="WP_088233257.1"
                     /transl_table=11
                     /translation="MRKRNKLWNLWKTITLLVCTVVIVSLLVTDVLISHNVEQATEDNQ
                     TEKAKTIARIVANDSIVIDGLTGKVDPSLIQVYTNKLLKNTDVQFIVVMDMNGIRKSHP
                     DPQKIGHHFLGGDEGPVLKGKEHVSLAKGTLGISMRVFVPIFADTGEQLGAVAVGISAD
                     NIKERVKESRHIIYIGVGVGILVGIIGAILLARHIKKSLFGLEPHRIAKILEERNTMLQ
                     SVKEGIIAVDKEAKVTLINNEAKRILKKDGITEDFIGKDIELYTQNSRMKEVLQTGEVQ
                     LNEELNFYGVTIVTNRVPLYVKGEIVGVIATFRDKTEIRKLAEELTGIRLYAEALRAQS
                     HEFMNKMHVVLGLTHMKQYEELQKYVSIMVSEHKYEIGGIMKKIQSPVFAGFLLGKLSY
                     AREKNIKLIIKEDSYLPDIYDERIIHELITIVGNLINNALDAVVDCEKKKVEIGIQYGD
                     TLIITVQDTGKGIQENEIDTLFIKGYSTKGDNRGYGLHLVKESIQRINGDIHVHSLLGT
                     GTTITIEIPKSRDER"
     gene            complement(3422..3601)
                     /locus_tag="COE07_RS01765"
                     /old_locus_tag="COE07_01765"
     CDS             complement(3422..3601)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000272495.1"
                     /locus_tag="COE07_RS01765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01765"
                     /product="DUF4177 domain-containing protein"
                     /protein_id="WP_078212233.1"
                     /transl_table=11
                     /translation="MYDYKFVKVEANKWNGEPKEDYKRIIAEHAEEGWKFVQIFAPATA
                     GYAKYFEIIFERTK"
     gene            complement(3741..4447)
                     /locus_tag="COE07_RS01770"
                     /old_locus_tag="COE07_01770"
                     /pseudo=""
     CDS             complement(3741..4447)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012259872.1"
                     /locus_tag="COE07_RS01770"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="COE07_01770"
                     /product="IS6 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGKQNLFKWKHYQPDIILLTVRWYLRYSLSFRDLVEMLEERGLSM
                     AHTTIIRWVHQYGPELDKRIRRHLKQTSDSWRVDETYIKVKGQWMYLDRAIDSKGNTID
                     FFLNKTRDQKAAKRFFKKALRSFHVSKPRVITVDKNPAYPIAIEQLKKEKSIPDGMQFR
                     Q"
     gene            complement(4589..5056)
                     /locus_tag="COE07_RS01775"
                     /old_locus_tag="COE07_01775"
     CDS             complement(4589..5056)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016135742.1"
                     /locus_tag="COE07_RS01775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01775"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_088233256.1"
                     /transl_table=11
                     /translation="MKICIKELNGGADNQECIKEIVELWNKNAIETAECELDESDRKAI
                     QEQIEQFIQSKYGVVFVAINENQQTIGYGIASMKQDLVSDMLYGQVDEVYVAPEYRRKK
                     VAKNLATDLMDWFNQKDISLIHVYVDLENELALEFWEKMGLDREFFILSNN"
     gene            complement(5031..6236)
                     /locus_tag="COE07_RS01780"
                     /old_locus_tag="COE07_01780"
     CDS             complement(5031..6236)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015380.4"
                     /locus_tag="COE07_RS01780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01780"
                     /product="clostripain-related cysteine peptidase"
                     /protein_id="WP_176548486.1"
                     /transl_table=11
                     /translation="MKLKGKNNFMSFLSTIFMGKRKSKYTLLIYMVGSDLESEYQEASM
                     NIKDLMKIGSSRHVNVILETGGAKKWELDLISSERNQRWIVQKNNLKLIQDDEKRNMDT
                     NEALSDFLIWGINQYPAEQYILILWGHGLGSVDGYGGDELYGNKAITLFTLQAALKEAF
                     DETKQKFNIISFDACSMAGIETAYSIRHYADYLVASVDYTNRNGLDYKTIIESLQQVPT
                     LSAKELGEVMVNSYRMYSKENGEKEDLQKGVIDLSKIDYIVEIVDSLGEKLLEDIEEHS
                     KFNVIIEARNYSEEYGEEADMVDLADLVSHLDNRLNYKKEANAICKAIEEAVIYNMKTP
                     EHPKGKGISIYFPKHDENRFKEKSLIYQQNEFSLHYREFIKLYSEKLIKGENRNENMYQ
                     GT"
     gene            complement(6214..8058)
                     /locus_tag="COE07_RS01785"
                     /old_locus_tag="COE07_01785"
     CDS             complement(6214..8058)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006212737.1"
                     /locus_tag="COE07_RS01785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01785"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_249278348.1"
                     /transl_table=11
                     /translation="MQKCTKYKLNIFMKIKTKWKEVKFACWGLKLIYQANPQRTTFVLM
                     IKLLESLLGPILVWLSAKIIDGLLKNHQAFFEFGPIFWMVVIFVSLTIFIDLLAPIVEM
                     NKKLLTAQIQKYIDELLINQANSFEDIAPFDDQNFYTKVKVARYNEYFVTLWLDMVANT
                     FGGIVQIIAGSILIWTVIPFVPFIFIILALPKIFVEAKLNNVTFEGREEVQELRRRAEY
                     YVSIPLNHELVNEVKMYNLTAFFKGKYKNVTNQLIKTLSHDQKKLTLHNVGWGLLEAIV
                     SGLVLIIIVKKAVSGTIAIGDLLLFIGALFQMREGVNELFSVFAIGAREMVNIRNIATF
                     ISYKSPKIAGTLSFPSNIQKGFRLKNVRFSYQKGEDVLNIDHLVIPEGKVTVLVGENGS
                     GKSTLVKLLLKLYEPISGTIYFNEKPLHAYNTNVMRMNSTAVFQDFVRYEMNLKSNIAV
                     GDINNFDDMSLIQNSAHLGGADKLVSQLPEGYETELGRFFGGINLSGGQWQRIAMARAF
                     MKDESAKILIFDEPTSALDPFMEYEIFTRLKQLGNNKTVIIISHQLSTAKLADNVVLLQ
                     QGEVIEYGNHHTLMEHGGVYAELYNMQADKYREVERKE"
     gene            complement(8006..9985)
                     /locus_tag="COE07_RS01790"
                     /old_locus_tag="COE07_01790"
     CDS             complement(8006..9985)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="COE07_RS01790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01790"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_088233254.1"
                     /transl_table=11
                     /translation="MKMLQNQEHSVDRLKNKQRYLLDQLKTMKLIGTMIWGSGPLLIIL
                     IFLFMLIQGLIPAIQLFSSKQIIDGISAKGESSDISIIWACIYAISMILMVLLDSIKKW
                     IGKILSERSLLSINLLLLEAWEKVPGMKFFDEKKYRNRLDTLQDATGWLPSQIITVSIN
                     FITGLISIGGIILLIGSLSPILAVLLVLSTIPYALKQNKYGELDWEYEKELAEDRRRMN
                     YARDMLLGRRASKEVRLFSLESFFLKLYRMKFQNIFTRFKIMQKSFVRGSILTGLLSGI
                     VAGLGYLWIIYQISNESISLGDIALYLLAIFQLSKELMGVSNDGADALELWRMGTDFRI
                     FIESEPDIHQVPNPQTGLYGEPMSIEFRNVTFKYPYGKHEEEEEEDDDDDDEYEYEYEY
                     EEDDDSLEDYDSDSHASFDDQDNDREYILNNVSFKILPGEHVALVGGNGSGKTTIVKLL
                     CRFYEPTSGSILINGRDIKTLDINELRSNISAIFQDYGKYSLTVEENITISDLQRQDKQ
                     KLKEVATIAQVDEFIKKLPNKYNSLLGPEWGGEDLSGGQWQRIAIARAIYQDSDLIIMD
                     EPTAALDIRAEYELYNNFRALAKGKSVLLISHRFSTVKMANRILVLKNGSIVEEGEHKQ
                     LMELGGEYAKMYKVQAEYFYENKD"
     gene            complement(10001..11992)
                     /locus_tag="COE07_RS01795"
                     /old_locus_tag="COE07_01795"
     CDS             complement(10001..11992)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="COE07_RS01795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01795"
                     /product="asparagine synthetase B family protein"
                     /protein_id="WP_088233253.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.1e-17, bitscore:
                     55.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIWVVMKSRNKSTWKSWTNNISSWLEDSLISYKETAQEEVSMAE
                     FTYRYEIYKRINIQKEKLNVPFVMDGWLKSSRSTNISTEEREELYQYAGGNLDELLSGG
                     DFTFSIWNKESKSLIFCSDLYGTRPIYYWVSPHKELFVSNDLRALLHINHIPFEIDYEH
                     CFLHLTSQYAMGEKNFEEDTFFKGIKKIPAATIAEWKLDKLKLTKYWGMEDLLKLPMIQ
                     KDYVQKFRDAMIESVNDRLYHSTSILEISGGLDSAGVLAAAIAGGNKHKVLGVNISFSS
                     DDMVQSNDRDIVRKLLTDLQIPGIIILGDNTLKIANAEIGRDPLWYIDGPDPRANVLIN
                     EMYNAIANEFKTDFGLTGEGGDFLFSGDEYVLDSLIRQGKFKKMLQTTWDWSDHKLGKA
                     IQLGAIYGIAPFIPVLNDRLYYKLAWSDDEYEMPQYFTHTHRERENKAKKDDYKRYLNS
                     KPLKYWGSRFHYDYTWPRASYLDAIGISMQNMHPFYDRRMIELSFSVPMEQHFNLERGK
                     EENYFGTKMLIRNAFTDILPSYIHNRVTKTSYAHMARKSLMNERSNLLNLFDHSEEVIL
                     DHLEIIDKKKFWEHLLGMLIRSSDINNDLGMSFQYLSMVVQMEIWLREMSKGKNHVLER
                     AKPCKPRWLSDIEIIGENQGFENFKSLG"
     gene            complement(11989..12462)
                     /locus_tag="COE07_RS01800"
                     /old_locus_tag="COE07_01800"
     CDS             complement(11989..12462)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024862.4"
                     /locus_tag="COE07_RS01800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01800"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_088233252.1"
                     /sec_met_domain="PF13471 (E-value: 1e-16, bitscore: 52.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIKLFQKNTDYKVYSLIIHSLIRNMFMNGDFKKSYQKLAVQMFP
                     LYESAIRRKENSINQKQLKEIGEYLFELDEEEQVVATCVSVAATLQVILFCKGIQAELL
                     IGVKKIDGKLFAHAWVKLPNGEVIDPQDKYSDLKVTQIFKLKDEAERWAVSVI"
     gene            complement(12459..12725)
                     /locus_tag="COE07_RS01805"
                     /old_locus_tag="COE07_01805"
     CDS             complement(12459..12725)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="COE07_RS01805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="COE07_01805"
                     /product="hypothetical protein"
                     /protein_id="WP_088233251.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.4e-11,
                     bitscore: 34.6, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIRQNDMVSSTIHDEEVVLLDMSKEIYYGLEGATMLLWNELSDG
                     PVDTIKILEKWKSKYDHSEEEVEHIFSQSLHELTSRDLVVIDT"
     aSDomain        complement(12468..12722)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_COE07_RS01805_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="2.20E-11"
                     /identifier="RREFam002.1"
                     /label="COE07_RS01805"
                     /locus_tag="COE07_RS01805"
                     /protein_end="86"
                     /protein_start="1"
                     /score="34.6"
                     /tool="antismash"
                     /translation="IIRQNDMVSSTIHDEEVVLLDMSKEIYYGLEGATMLLWNELSDGP
                     VDTIKILEKWKSKYDHSEEEVEHIFSQSLHELTSRDLVVI"
     gene            complement(12827..12949)
                     /locus_tag="COE07_RS28155"
     CDS             complement(12827..12949)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016135744.1"
                     /locus_tag="COE07_RS28155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_255291267.1"
                     /transl_table=11
                     /translation="MKLTVGKVKEYGTFMNLTLAKSGKPGDGKHGKGKRGMKKA"
     CDS_motif       complement(12893..12949)
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MKLTVGKVKEYGTFMNLTL"
                     /locus_tag="COE07_RS28155_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       complement(12827..12892)
                     /prepeptide="core"
                     /locus_tag="COE07_RS28155_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="-5.20"
                     /molecular_weight="2105.5"
                     /monoisotopic_mass="2104.2"
                     /core_sequence="AKSGKPGDGKHGKGKRGMKKA"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MKLTVGKVKEYGTFMNLTL"
                     /leader_location="[12892:12949](-)"
     gene            complement(13166..13288)
                     /locus_tag="COE07_RS28160"
     CDS             complement(13166..13288)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016135744.1"
                     /locus_tag="COE07_RS28160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_255291267.1"
                     /transl_table=11
                     /translation="MKLTVGKVKEYGTFMNLTLAKSGKPGDGKHGKGKRGMKKA"
     CDS_motif       complement(13232..13288)
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MKLTVGKVKEYGTFMNLTL"
                     /locus_tag="COE07_RS28160_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       complement(13166..13231)
                     /prepeptide="core"
                     /locus_tag="COE07_RS28160_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="-5.20"
                     /molecular_weight="2105.5"
                     /monoisotopic_mass="2104.2"
                     /core_sequence="AKSGKPGDGKHGKGKRGMKKA"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MKLTVGKVKEYGTFMNLTL"
                     /leader_location="[13231:13288](-)"
     gene            complement(13507..>13698)
                     /locus_tag="COE07_RS28165"
                     /pseudo=""
     CDS             complement(13507..>13698)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010896456.1"
                     /locus_tag="COE07_RS28165"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="RSIEKLRSAIE"
     misc_feature    14625..14641
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 25.85"
                     /tool="antismash"
     gene            14926..15534
                     /locus_tag="COE07_RS01810"
                     /old_locus_tag="COE07_01810"
     CDS             14926..15534
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018783231.1"
                     /locus_tag="COE07_RS01810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01810"
                     /product="DUF998 domain-containing protein"
                     /protein_id="WP_018783231.1"
                     /transl_table=11
                     /translation="MYISNRIGLFSWITTCLYFLIEPFFIFTSTVPYNYLHHAMSDLGV
                     TTCGKFTYEIAPYEICSPNHFWMNLLFIINGLTFCIGVLYISQHLEKTKINKIATFFIL
                     IIGVSTIVSGLIPADVNLIGHSILVWIGMLTVYPGLFIFARNLKKAKKWTYFCLLSLIL
                     IIILISLVFLFPLPSGLLQRLFYLVLFVWGTVSTYKLIK"
     gene            complement(15892..16446)
                     /locus_tag="COE07_RS01815"
                     /old_locus_tag="COE07_01815"
     CDS             complement(15892..16446)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001231978.1"
                     /locus_tag="COE07_RS01815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01815"
                     /product="DUF4352 domain-containing protein"
                     /protein_id="WP_088233250.1"
                     /transl_table=11
                     /translation="MRKLSILLTLSLVFVSVMGACTQDKKDNAVENNSIEEPTAKNENE
                     ELINFEEKENISRLEQGILLVGESAKGGYYLTTVQSAYLNDNNDSIVVNVSVKNVRGQM
                     IGLSELKYTLKDEKNGKTYEGKLLDQNPSDIQVKPNETVELKIAFEVPGTADEYMFYIE
                     SSLDSLGTTHWKIDKLQSPKN"
     gene            complement(16473..16640)
                     /locus_tag="COE07_RS27750"
                     /old_locus_tag="COE07_01820"
     CDS             complement(16473..16640)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="COE07_RS27750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="COE07_01820"
                     /product="hypothetical protein"
                     /protein_id="WP_170933807.1"
                     /transl_table=11
                     /translation="MEFILYFGFYFGLPFLIIGTALFLFLMVALPKNRNKNLSFVMIGL
                     GVNLFTVAQN"
     misc_feature    16714..16733
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 19.76"
                     /tool="antismash"
     misc_feature    complement(16752..16764)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     gene            complement(16804..18465)
                     /gene="ltrA"
                     /locus_tag="COE07_RS01825"
                     /old_locus_tag="COE07_01825"
     CDS             complement(16804..18465)
                     /EC_number="2.7.7.49"
                     /GO_function="GO:0003964 - RNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000373 - Group II intron splicing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ltrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006096946.1"
                     /locus_tag="COE07_RS01825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01825"
                     /product="group II intron reverse transcriptase/maturase"
                     /protein_id="WP_098840796.1"
                     /transl_table=11
                     /translation="MNTSERASAHVSYTEWNSTDWKAVQMYVTKLRQRIYRAEQSNQHR
                     KVRKLQRLLLRSEANLIISIRRVTQQNKGKRTPGVDEHTALSRRERNQLYEQLRKQNIL
                     RHHPKPAKRIYIAKKNGKLRPLGIPTIKDRVYQNMVRNALEPQWESRFEANSYGFRPKR
                     STHDAIRSIFNRINGGSKKKWIFEGNFKGCFDHLNHNWILKQLANFPGSQLIERWLQMG
                     YMERNAFSETQEGTPQGGIISPLLANVALHGMEEALGITYKKNYKANGSYIIHPACKIA
                     LVRYADDFVVLAETKEQAQSIYERLRPYLKDRGLELSLEKTKVTHIERGFEFLGFSIRQ
                     YKTWKGNKLFIKPSRSGIQKAKEKIRDTFRTMKGQPIGEVIRVLNPIIGGYGQYWKHVV
                     SKRIFSKIANYVFWKVRKHLRQLHPKKSWKWIRARYYKAPHHGGNVWVPTCPKTNIQLL
                     HMPWIKIERHVMVMYKNSPDNPTLKEYWEKRDRKVFNLENTMDRMKLARKQGYRCAICK
                     CPLQNGEKVIVKDMPIHQSHLQPNGNTRLVHLPCLQ"
     cand_cluster    17099..26537
                     /candidate_cluster_number="3"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    17099..26537
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[22098:24968]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      22099..24968
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     gene            complement(19778..20050)
                     /locus_tag="COE07_RS01830"
                     /old_locus_tag="COE07_01830"
     CDS             complement(19778..20050)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002129808.1"
                     /locus_tag="COE07_RS01830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01830"
                     /product="hypothetical protein"
                     /protein_id="WP_088232703.1"
                     /transl_table=11
                     /translation="MKNHHEFINLALDCERIIKQNIPSNPDDAKRYHLMLNELKGLRMT
                     IKLNQLNDKLYYLAITQMLEKDDPKKVLQAVLKLNTFYCNYYQNL"
     gene            complement(20071..20751)
                     /locus_tag="COE07_RS01835"
                     /old_locus_tag="COE07_01835"
     CDS             complement(20071..20751)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002204983.1"
                     /locus_tag="COE07_RS01835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01835"
                     /product="autotransporter"
                     /protein_id="WP_088232704.1"
                     /transl_table=11
                     /translation="MRKYFASIIMLILLMVYFPLSVTYAQEKNINLSNIEQMTIVFNDN
                     TNLGEKISYIRNSDLNNWPVEEMNQALDKIDNLNLSIMERASLKREVIRSSGFSNFDFK
                     DTKSDVLAFKELKIEIIETDTLLTLYRRSKAGEPESKYGLGYWWGDKERNIEETRNELA
                     VLEAWGNPLNIQYKITVPKGTRMLKGFTASQTQYLKGTSIVQEYREGGAMQYWINKIDN
                     SWLQ"
     gene            complement(20793..22106)
                     /locus_tag="COE07_RS01840"
                     /old_locus_tag="COE07_01840"
     CDS             complement(20793..22106)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1029: RND family
                     efflux transporter MFP subunit"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000041333.1"
                     /locus_tag="COE07_RS01840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01840"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_088232705.1"
                     /transl_table=11
                     /translation="MSKIYSFDQLTDSVELLERKPPRFIAGLLVFLLMSLFTFLIWAYV
                     SKIDIVSKGTAMIQGKSDASVSRTQIVGVVDMVAVKSGDEVKKGDILIQLKNQELTDKQ
                     NQVNQIVEHLEKQKGMLEQLKESIRSHKSSFPDDVDKKIREEYQAYDQRYQSIQNENDN
                     EIKKIEHGKFSNEQDEVLQGLIAEKENIQREIDTIEKQKTKENILEDQKQVMNDKIGNL
                     ESQQNSVEKRIQQRKETLEHERTKVDVTKEGKQEQKKDALNQYKEEYMISVNQRIQSLE
                     QELFIKKQELDGLRHQNETTIIKAQKNGIVQFPSILQQGDLINPGQEIVSIIPKEEQKK
                     VRILLPAQEIKGIKKGDKVQYSFKLQKTDKQMGQITYVSAYPTFDKNTKGYMYELEATI
                     DTKELQELHTGMVGRASVITGEEPVWKYILRKLDFISN"
     gene            complement(22099..24318)
                     /locus_tag="COE07_RS01845"
                     /old_locus_tag="COE07_01845"
     CDS             complement(22099..24318)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002204985.1"
                     /locus_tag="COE07_RS01845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01845"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_088232706.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.1e-41, bitscore:
                     132.8, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 5e-209, bitscore:
                     687.1, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKKKFTCIKQQDLKDCGPACLAMISRYYGFTMSISKIREIAGTD
                     LEGTNIKGLIEAGEKLGFGVKGVKATNFEALEKITLPAIAHVVMGGGLLHYVVIYKVKN
                     NKIYIADPEKGFVTYLLEEFGQIWTGILVLMTPTENFQKGKALQSTLSRFLFLLKQQTN
                     LLVPLFFASIFFNLFGLLGAFYFKFLIDDIVTNQLLQTLHIVSIGIIILYIFKVLLSYF
                     RTHLILYLSRRIDIQLMLGYYRHVVGLPINFFETRKIGEIISRFMDASKIRDALSTITV
                     TLMIDTVMVTLGAILLYIHSPVLFGFTLLLIPFYIGIIFAFHKPYQSINREEMESNAKL
                     NSYLVESLNGIATIKSYNAEKEVFFQTESRFVNLLKHVFKRGMLSNLQVSIKIGLELIG
                     GTVILWIGAMQVLKGNMTIGELITYNALLAYFLNPIENLIGIQPTMQSALVAGERLNEI
                     FDLDQEKSEKEDNKVSPKQLSGKIECSNVTFRYGTRKNVLNNISFSIEPGSQAAFVGES
                     GSGKTTISKLLMHYYESQQGDIYYDDYHVKEINRTALRDRIAYVSQESFFFSASIYENL
                     CFGLEQKVTLEEVIQVCKQACVHEFISELPLRYETFLEENASNLSGGQRQRLAIARALL
                     KKPDILILDEATSNLDSTTEKHITDMLKELGSQGVTVIMIAHRLSTIQHASQIFVMEKG
                     NIIERGSHEELLFYKGEYYRLWKNQTVHVEHIESQSYVMGDNQYE"
     gene            24531..24755
                     /locus_tag="COE07_RS01850"
                     /old_locus_tag="COE07_01850"
     CDS             24531..24755
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000764648.1"
                     /locus_tag="COE07_RS01850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01850"
                     /product="hypothetical protein"
                     /protein_id="WP_002204986.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 3.3e-12,
                     bitscore: 37.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKINEMTEQLTEKELLEISAGGSCLNKIGAGVVKGIFAGGAAGAA
                     ATMGLGTAGGAFVGAHIGAAAGAITCLGE"
     gene            24777..24968
                     /locus_tag="COE07_RS01855"
                     /old_locus_tag="COE07_01855"
     CDS             24777..24968
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002204987.1"
                     /locus_tag="COE07_RS01855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01855"
                     /product="Blp family class II bacteriocin"
                     /protein_id="WP_070147273.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.5e-13,
                     bitscore: 41.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEINNTLTKLSEEELENINGGGCTWKKAAAEAAGGIIIGSMGGP
                     WGALGGGVTGVALCYLND"
     misc_feature    25122..25137
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 19.72"
                     /tool="antismash"
     gene            25142..25345
                     /locus_tag="COE07_RS01860"
                     /old_locus_tag="COE07_01860"
     CDS             25142..25345
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002204988.1"
                     /locus_tag="COE07_RS01860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01860"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_070147270.1"
                     /transl_table=11
                     /translation="MLNIKMKLTRIEKGLTQKQLADLVNVSRQTIGLIEKEEYNPSLKL
                     CLSICIALDKTLNDLFWEGEIK"
     gene            25342..25821
                     /locus_tag="COE07_RS01865"
                     /old_locus_tag="COE07_01865"
     CDS             25342..25821
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="COE07_RS01865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="COE07_01865"
                     /product="hypothetical protein"
                     /protein_id="WP_070147268.1"
                     /transl_table=11
                     /translation="MKTIIEKILLGQKSNDEYQEKAYTKYIAEAGILVMLINFLYLTTK
                     TIYLKEISTDIIVCLTLFLIFCGYITIRIFKSNIDFINITSETDLEKNKKKLLKNTILQ
                     SIIFFIVFSGSGYVIDSPSSWTLNIITSIFFGIAIYLINKTNAKKSLKMNNELND"
     misc_feature    26025..26041
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.79"
                     /tool="antismash"
     gene            26314..>26537
                     /locus_tag="COE07_RS01870"
                     /old_locus_tag="COE07_01870"
                     /pseudo=""
     CDS             26314..>26537
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012259872.1"
                     /locus_tag="COE07_RS01870"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="COE07_01870"
                     /product="IS6 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEKENVFKWKHYQPDIILLTVRWYLRYNLSFRDLVEMMAERFLSI
                     SHTTIMRWVHQYGPELDKRIRRHLKQTND"
ORIGIN
        1 aaatcgtttg ataaagttgc agataagcta ttctgccttg gataggcctc aatctttgca
       61 ccagaatcag aaagattact aatttttatt tacaattaat agtttcaaat ccaataacat
      121 ttcgacaatg gaattaatag ttttgttttg agcactatag taaatctgta atccttttct
      181 atcactcata attaattttt gagatttcat cttcgataaa tgctgcgaaa cagtagattg
      241 tgggatacca agaatatcta caatttgagt tacattacat gcccctcttg taattaactc
      301 tttcaaaatt ttaattcgta ttggatgagc taatgctttt aaaactgctg cgtttttttc
      361 ataattcaac aaactaaaca tctccttgtg aaccgatata tttttattat attaataact
      421 tgatgaataa aattttaata ttctagtttt gcagaattta tgctgcagca tcttttcgat
      481 ttaatttgtg ttttattccg tcaagatgat ccggtatgct ccagacccct ttattctctt
      541 ttttacttgc atttctactt cctttaattc atctgaacaa taatattaaa atgctttcaa
      601 tagtaaaaat agtttttgta atttttataa ttacttttgt aattaaaaaa atataagcga
      661 cttataataa gtcgcttata cgtaaaaatc tattttattt tggtcaatac atctcaattt
      721 actcactggt cttcccacat tttgatacac tatttcattc tctaatactc cgatttcagt
      781 caaaaacatt acatactttc gaatagaaac tcttgaaact cctactaatt gtgccatttc
      841 atctgttgta aacgctcgtc cattcagcga ctcgatcttc tgccaaatta attgcaacgt
      901 ttgcttcgtt aatccttttg gaagcacttt atcgtcaaag ggcactcttt tttctttttg
      961 taaaattagc gaatctaatt ccgattgact aatttctggt tgttctttca taaaagtaaa
     1021 tttttctcga tatacagtta atgcctcttt aaatcgttca aatgtaaatg gtttaattaa
     1081 ataatctacc acgccatatt gtaatgcttt tttgatactc cccatatcat gtacagctga
     1141 aatcatcata atatcgattt ctttctcttg attccgaata tgcattaaaa gctcaaaccc
     1201 ggtctcttca ggcataaaaa tatcaagtaa tactaaatct acttgtgatt tctctaatac
     1261 ttctatcgct gctttaactg atttaactgc atggacaagt tcaaaccctc ccacttgctc
     1321 taaataatgc gtatttaaca ttgcgaccat cgggtcatct tctaaaatca aaactttgat
     1381 catcttatct ctcatcccta cttttaggta tttcaatcgt tattgtcgtt cccgttccta
     1441 acaatgaatg aacatgaatg tccccattta ttcgctgtat gctttccttt acaagatgca
     1501 aaccataccc tcgattatca ccctttgtgg aataaccttt tataaataac gtatcaattt
     1561 cattttcttg tatgcctttg cctgtatctt gcactgtaat gattaatgta tccccatatt
     1621 gtattccaat ttcaaccttc ttcttctcac aatccaccac tgcgtctaat gcattattaa
     1681 ttaaatttcc gacaatggtg atcagttcat ggatgatacg ttcatcatat atatctggta
     1741 agtaagaatc ttcttttata attaacttta tatttttctc tctagcataa ctaagtttac
     1801 ctagtaaaaa tccagcaaat actgggcttt gaattttttt cataatcccc ccaatttcat
     1861 atttatgctc tgacaccata atacttacat atttttgaag ttcttcatac tgtttcatat
     1921 gtgtaagtcc tagcacgaca tgcatcttat tcataaattc atgagattgt gcccgtaatg
     1981 cttccgcata tagcctgata ccggttagtt cctctgccaa ttttctaatc tctgttttat
     2041 cacgaaatgt tgcaatcacg ccaactattt ctccttttac atataaagga acccgattcg
     2101 taacaatcgt aaccccataa aaatttagtt cttcgtttaa ttgtacctcc cctgtttgca
     2161 acacttcttt catacgtgaa ttctgcgtat acaattcaat atctttaccg ataaaatctt
     2221 ctgtaattcc atctttcttt aatattcgtt ttgcttcatt attaattaac gttacttttg
     2281 cctctttatc tacagcaata ataccttctt ttacagattg tagcatcgta tttctttctt
     2341 caagaatttt cgctatccta tgcggctcaa gaccaaataa acttttcttt atatgtctag
     2401 ctagcaatat cgctcctata attccaacca atattccaac accaacaccg atataaataa
     2461 tatgtctact ttctttcacc ctctctttta tattatcagc tgaaatgcca acagcgaccg
     2521 caccaagttg ctcacctgtg tcagcaaaaa taggtacgaa tactcgcata gaaatcccta
     2581 aagttccttt tgctaacgag acgtgttcct ttcccttcaa tacaggtcct tcatcgcctc
     2641 caagaaaatg atgccctatt ttttgagggt ctggatgaga ttttcgtatt ccattcatat
     2701 ccataactac aataaattgt acatctgtat tctttaatag cttatttgta tacacctgaa
     2761 tcaaggaggg atctaccttc cccgtcaacc catcaattac aatagaatca ttcgccacaa
     2821 tacgtgcaat cgtttttgcc ttctctgttt ggttatcttc tgtcgcctgt tcaacattat
     2881 ggctaattaa aacgtctgtt acgagtaaag aaacaattac aacggtacaa actaacagtg
     2941 taatggtttt ccataaattc catagtttat ttctttttct cattccttca atagctcccc
     3001 tagttattaa gcagaaaaat aagtaaggtg atatcatttt caccttactt atttgctgtt
     3061 attatacttt aaatttactc gtcatttctt gtagtttttt agcgtctctt ctctgctaag
     3121 ttttaattag ctaaacgaaa ttattacata ataaaaaata gaataagagg aattcaatat
     3181 aacaagtata ctaaatttct cttattttca tttcgaaaat ttaatattgt cattactttt
     3241 gttgtgacaa gaagcataag atggccgttt tggtcaactt atgcttcttt tagtttgcgg
     3301 ccaacttatg cttctaatat gtatacaaca aaaataacaa ctagcccctc gtaagaggta
     3361 ctagttgacg taaaatccgt tattggaagt tattgcaaac ccctctcgtt ctcgacagga
     3421 gttatttggt tcgttcgaag ataatctcaa aatatttagc gtatcctgca gttgctggag
     3481 caaagatttg aacaaatttc caaccttctt cagcatgttc ggcaataata cgtttataat
     3541 cttctttagg ttccccattc catttattag cttcgacttt aacaaatttg taatcgtaca
     3601 tattctctcc tccttttcct aattgtatca tttagaagaa gtgatatgtt ttgtaattct
     3661 agttgtatat tttatacggt tttggtgcaa agataaaata aaagagaata aagcgtatat
     3721 attcctaacg gaatcgtatc ttatgctgca aatccaaaca attgatggat gaattctttc
     3781 tgattttgga cagactggtc ttgtaaatca atctgttctt ttttaatcat atgcatgact
     3841 tctaatccag aaagaatgga tgtagctgtg tcaaaacatt taaccctagc atagaacgga
     3901 ttcgcttctt tataaagcga tgatcttatt ctactatgtt attcaagtac ttttattgtc
     3961 taaattgcat accatcaggt atgctttttt cttttttcaa ctgttcaatt gctataggat
     4021 aagccgggtt cttatcgacc gttataacac gtggctttga aacatgaaaa gaccgcaaag
     4081 ctttcttgaa aaagcgtttt gcagccttct ggtctcttgt tttatttagg aaaaaatcaa
     4141 ttgtgtttcc tttcgaatca atagcacgat ccaaatacat ccattgacct tttactttga
     4201 tatatgtttc atcgactctc caagagtcac ttgtttgttt gaggtgacga cggatgcgtt
     4261 tgtccaattc aggtccatat tgatgaaccc aacgtataat cgttgtgtga gccatggata
     4321 agccgcgttc ctccagcatt tccaccaaat cacgaaaact gaggctgtac cgtaggtacc
     4381 atctcactgt taacaaaata atgtcaggct gataatgctt ccatttgaat aaattttgct
     4441 ttcccatacc gatcgcaccc ctttttttag agtaataata tcagtatgcc caagatttag
     4501 agattacttg caattgccct aaagtttttg caccagaccc ctaataaata gcaatttttt
     4561 ataatagaga tacgtatttt attataaatt aattatttga tagaataaaa aactccctat
     4621 ccaaacccat tttctcccaa aactctaagg ctagctcatt ttctagatca acataaacat
     4681 ggattaaaga aatatccttt tggttaaacc agtccattaa atccgttgct aagtttttag
     4741 caactttctt tcttcgatat tctggtgcta cataaacttc atctacttga ccatataaca
     4801 tatcgctaac taaatcttgt ttcatagaag caataccata gccaatagtt tgctggttct
     4861 cattaattgc tacaaaaacc acaccatatt ttgattggat aaattgttct atttgctcct
     4921 ggatagcctt cctatcactc tcatctaatt cacattctgc agtttctata gcatttttat
     4981 tccacaattc tacaatttcc tttatgcatt cttggttatc cgcaccaccg ttaagttcct
     5041 tgatacatat tttcattcct attttctcct tttattagtt tttcagaata taatttaata
     5101 aactccctat aatggagtga aaattcattt tgttgataaa ttaaagactt ttctttaaat
     5161 ctattttcat catgttttgg aaaatagata gaaatccctt tccctttagg atgctcagga
     5221 gtcttcatat tataaataac agcttcttca attgccttac aaattgcatt agcttctttc
     5281 ttgtaattaa gtcgattatc tagatggctg actaaatctg ctaaatctac catatcagct
     5341 tcttcgccat attcttcaga ataatttctt gcttctatta ttacattgaa ttttgaatgt
     5401 tcttctatat cttctaatag tttttctcct aaactatcta caatctctac aatataatca
     5461 attttactta gatcaataac tcctttttgt aaatcttctt tttccccatt ttctttggag
     5521 tacattcgat aactattgac catgacttcc cctaactcct tcgcagataa tgtaggaact
     5581 tgttgtaaag attcaataat tgttttataa tccaatccat tacgattagt ataatctaca
     5641 gaagctacta agtaatcggc ataatgcctt attgagtaag cagtttcaat cccagccata
     5701 ctacaagcat cgaagctaat aatattaaat ttttgttttg tttcatcaaa ggcttctttc
     5761 aaagcagctt gcaatgtaaa taatgttatt gccttattac catacaattc atctccacca
     5821 tacccatcta ccgaacctaa tccatgtccc catagaatca atatgtattg ttcagcggga
     5881 tattgattta taccccaaat taaaaaatca cttaatgcct cattagtatc catatttctc
     5941 ttttcatcat cttgtattaa ctttaaatta tttttttgga caatccatcg ttgattacgt
     6001 tctgaggaaa taagatctaa ttcccatttc tttgctcctc ctgtttctaa tataacgtta
     6061 acatgacgag aagatccaat tttcattaaa tcttttatat tcatacttgc ttcttgatat
     6121 tcgctctcta aatctgatcc caccatataa ataagtaaag tgtattttga ttttcttttt
     6181 cccataaaaa ttgtagaaag aaaagacata aaattattct ttcctttcaa cttcacggta
     6241 tttatctgct tgcatgttat ataactcagc atatactcct ccatgttcca ttaaagtatg
     6301 atgatttcca tattcaatga cttctccttg ctgtagaaga acaacattat ctgctaattt
     6361 ggctgtgcta agttgatgtg agataataat caccgtttta ttgtttccta actgttttaa
     6421 acgagtaaat atttcatatt ccataaaagg atctaaagcc gatgtgggtt catcgaaaat
     6481 taaaatcttt gctgattcgt ctttcataaa tgctcgtgcc atcgcgatac gttgccattg
     6541 tccacctgaa agattaatac caccgaaaaa acgtccaagt tctgtctcat agccttctgg
     6601 caattgagat accaatttat cagctcctcc aaggtgagct gaattttgta tcaaagacat
     6661 atcatcaaaa ttatttatat cacctacagc aatatttgac tttagattca tttcatagcg
     6721 gacaaaatct tggaacacag ctgtagagtt catgcgcatt acattagtgt tataggcatg
     6781 aagtggtttt tcattaaaat aaatggtgcc actgattggt tcataaagct tgagtaacaa
     6841 ttttaccaat gtgctttttc cagatccatt ttctccaact aatactgtaa cttttccttc
     6901 aggtatcacc aaatgatcaa tgtttaaaac atcttcccct ttttgataag aaaagcgaac
     6961 gtttttcaac ctaaatcctt tttgaatgtt agatggaaat gataaggtac ctgctatttt
     7021 cggggatttg tacgaaataa atgtagcaat attacgaata ttaaccattt ctctggctcc
     7081 aattgcaaat acagagaata gctcatttac tccttctctc atttggaaca atgccccaat
     7141 aaataataat aagtcaccaa tagcaatagt tccagaaaca gcttttttta caattataat
     7201 taaaaccaat ccacttacta tagcttctaa aagtccccat cctacattat gcaaagttaa
     7261 tttcttttga tcgtgtgata aagttttaat caattgatta gtaacatttt tatatttccc
     7321 cttaaaaaat gctgtcaaat tatacatttt aacttcattt actaactcat ggttgagagg
     7381 aatactaacg taatattcag ctcttcttct taactcttga acttcttctc gtccctcaaa
     7441 tgtaacatta ttcagctttg cttctacaaa tattttagga agagctaaaa taataaatat
     7501 gaatggaaca aatggaataa ctgtccaaat caaaattgat cctgctataa tttgaacaat
     7561 accaccaaat gtatttgcta ccatgtccaa ccataacgtc acaaaatact cattgtatct
     7621 tgcaactttc accttagtgt aaaagttttg atcatcaaat ggtgcgatat cttcaaatga
     7681 atttgcttgg ttaattaaaa gttcatcaat atatttttga atttgtgcag taagtagctt
     7741 tttattcatt tctacaattg gagcaagtaa atcaataaaa attgttaaac tcacaaatat
     7801 tactaccatc caaaatatgg gtccgaactc aaaaaaagct tgatgattct tgagtaaacc
     7861 gtcaataatt tttgcgctta gccaaacaag tattggcccc aataaagatt ctaataactt
     7921 aatcattaag acaaaagtgg ttctttgcgg atttgcttga taaattaact tcaatcccca
     7981 acaagcaaat ttaacctctt tccatttagt ctttattttc ataaaaatat tcagcttgta
     8041 ctttgtacat ttttgcatat tctccaccca gttccattaa ctgtttatgc tctccttctt
     8101 ctacaataga accatttttt aaaaccagaa tacgattagc catttttact gtgctaaagc
     8161 gatgtgagat taatagtaca gattttcctt ttgcaagcgc acgaaagttg ttatatagct
     8221 catactcagc tcttatatca agagcagcag taggttcatc cataataatt aaatcagagt
     8281 cttgataaat agcgcgagct attgctatac gttgccattg tccacctgat aaatcttctc
     8341 ctccccattc tggtcctagt aaactattat acttattagg taactttttt ataaattcat
     8401 ctacttgtgc aattgtagct acttctttca atttctgttt atcttgtctc tgtaaatcag
     8461 agatagtaat attctcttca actgtcaaac tgtatttccc ataatcttga aaaatagcag
     8521 agatattgct tcgtaattca ttaatatcta atgtcttaat atctcgacca ttgattaata
     8581 tagaaccact agtcggctca taaaatcgac aaagtaattt gacaattgtt gtttttcctg
     8641 aaccattacc acctactaaa gctacatgtt caccaggtaa tatcttgaaa ctcacattat
     8701 tcagtatgta ttctctatca ttgtcttgat cgtcgaaact tgcatggcta tcactatcat
     8761 agtcttctaa tgaatcatca tcttcttcat attcatattc atattcatac tcatcatcat
     8821 catcatcatc ttcttcttct tcttcttcat gcttgccata tggatattta aaagtaacat
     8881 ttctaaattc aatggacatt ggttccccat acaatcctgt ctgaggatta ggtacttgat
     8941 gtatatctgg ttcggattca ataaatatac gaaaatctgt acccatacgc cataattcaa
     9001 gagcatcagc cccatcatta cttactccca ttaattcttt tgataactga aagatagcca
     9061 ataagtatag agcaatatcc ccaagtgata tagattcatt actgatttga tatataatcc
     9121 ataagtaacc taatcccgca acaattccag ataataaacc cgttaaaatt gatccacgca
     9181 caaatgattt ttgcattatt ttaaatcgtg tgaatatatt ttggaatttc attcgataca
     9241 gttttaaaaa aaatgattct aaactaaata gtctaacttc cttactagca cggcgaccta
     9301 acagcatatc acgagcataa ttcatacggc gtcgatcttc tgccaattct ttttcgtatt
     9361 cccaatccaa ttcaccatac ttgttctgct taagagcata gggtattgtg cttaacacaa
     9421 gtaaaaccgc aaggataggt gataagctac ctattaataa aatgattcca ccaattgata
     9481 ttaggcctgt aataaaattt atactgaccg ttataatttg agatggtaac catccagtag
     9541 catcttgcaa tgtatctaaa cgattgcgat attttttttc atcaaaaaac ttcattccag
     9601 gaactttctc ccaagcctct aaaagaagta gattgataga tagcagagaa cgttccgaca
     9661 aaatttttcc aatccatttt tttatagagt ctagtagtac cattagaatc atactgatag
     9721 cataaataca cgcccagata atacttatgt cactactctc cccttttgca ctaataccat
     9781 cgataatctg cttggaagaa aataattgaa ttgcaggtat taatccttgt attaacataa
     9841 acagaaatat aagtataatt aataaaggtc cagaccccca tatcatcgtt cctataagct
     9901 tcattgtttt cagctgatct agtaagtatc gctgcttatt ttttaatcta tcaaccgaat
     9961 gctcctgatt ttgtaacatt ttcatcacca acacctattt ttagccgaga cttttaaaat
    10021 tctcaaatcc ttggttctca ccaataattt cgatatctga taaccacctt ggtttacatg
    10081 gttttgccct ttctaataca tgatttttcc ctttactcat ctctcttaac catatttcca
    10141 tttgtacaac catagacaaa tattgaaatg acatacctaa atcattatta atatccgagg
    10201 aacggattaa catccctaat aaatgttccc aaaacttttt cttatcaata atttctaagt
    10261 ggtctagtat tacttcctct gaatgatcaa ataaatttaa taaattacta cgttcattca
    10321 ttaaactttt cctagccata tgtgcgtagg acgtcttggt tactcgatta tgaatataag
    10381 aaggtaaaat atccgtaaat gcattacgaa tcaacatctt tgttccaaaa taattctctt
    10441 cttttcctct ttcaagatta aaatgttgtt ccattggtac agaaaatgat aattctatca
    10501 ttctacgatc atagaaagga tgcatatttt gcattgaaat tccaatggca tctaaataac
    10561 tggctctagg ccatgtatag tcataatgga atctacttcc ccaatattta agtggtttac
    10621 tattaagata acgtttatag tcatcctttt ttgctttatt ttctctctct cgatgagtgt
    10681 gtgtgaaata ttgtggcatc tcatactcat catctgacca agctaactta taatataatc
    10741 tatcattgag cacaggaata aatggagcaa taccataaat tgcccctagt tgaattgctt
    10801 tacctaattt atgatcagac caatcccatg ttgtttgtaa cattttctta aattttcctt
    10861 gtctaatcaa agaatctaat acatactcat ctccagaaaa taaaaagtct ccaccttcac
    10921 ctgtcaaacc aaagtcagtt ttgaattcat tagcaatagc attatacatt tcattaatta
    10981 acacattagc tcttgggtca ggtccatcta tataccataa gggatctctc ccgatttccg
    11041 catttgcaat ttttaatgta ttgtcaccta aaataataat tccaggtatt tgtagatcag
    11101 ttaataactt acgcacaata tccctatcat tgctttgtac catatcgtcg ctggaaaatg
    11161 atatatttac acccaatact ttatgtttgt taccgcctgc aatagcagct gcaagaactc
    11221 cagctgaatc taaccctcca cttatttcta atatagaagt agagtgataa aggcgatcat
    11281 taacggattc aatcatagca tcacgaaatt tctgaacata atctttttga atcataggta
    11341 actttaataa gtcttccata ccccaatatt ttgttaattt caatttatcc aatttccact
    11401 ctgcaatggt agcagcggga atctttttaa ttcctttgaa aaatgtatct tcttcaaagt
    11461 ttttttcccc cattgcatat tgagaagtta aatgtaaaaa acaatgttca tagtcaattt
    11521 caaatggaat atggttaata tgtaaaagtg ctctaagatc attggataca aatagttctt
    11581 tatggggact aacccagtaa taaataggac gtgttccata caaatcgcta caaaaaatta
    11641 aagatttaga ttctttattc catattgaaa aagtaaaatc accaccagac aacaattcat
    11701 ctaaatttcc acctgcatat tgatataatt cttctctttc ttcagttgat atatttgttg
    11761 atcgagaaga tttcagccaa ccatccatta caaaaggaac atttaacttt tctttctgaa
    11821 tattaattct tttatatatt tcatatctgt aagtgaactc tgccatgcta acttcttcct
    11881 gtgccgtctc tttgtaactt atcaaagaat cttctaacca actagagata ttatttgtcc
    11941 aacttttcca agtagattta tttctacttt tcattacaac ccatattttc atattactga
    12001 aacagcccac ctttcagctt catcttttaa tttaaatatc tgcgttactt ttagatcact
    12061 atatttatct tgtgggtcaa taacttcacc attaggaagt ttaacccatg catgagcaaa
    12121 tagttttcca tcaatttttt taacaccaat aagcaattca gcttgaatac ccttacaaaa
    12181 caaaattact tgtaaagtcg ctgccactga aacacatgtt gctactactt gctcctcttc
    12241 atcaagttca aataaatatt cacctatttc tttcaattgt ttttggttaa tagaattttc
    12301 ttttctacgt attgcacttt catacagagg aaacatctga acagctagtt tttgataaga
    12361 ttttttaaaa tccccattca tgaacatatt acgtatcaat gaatgaataa taagggaata
    12421 aaccttataa tctgtgtttt tttgaaataa tttaattatc atgtgtcaat cacaaccaaa
    12481 tctctagaag taagctcatg taaggattgt gagaaaatat gttccacttc ttcttctgaa
    12541 tgatcatatt tagatttcca tttctccaga atctttatgg tatctacagg gccatcagac
    12601 aattcattcc acaacaacat tgttgcccct tccagaccat aataaatttc tttagacata
    12661 tctaagagaa ccacttcttc atcatgaatt gttgaagaca ccatatcatt ttgtctaatt
    12721 atcatgtttc aatttctctc tccatttcca tatagttata gaatgagaga gttgctacat
    12781 gcaaactctc tctacaaaaa tactattttg acggaactta aaagtattaa gctttcttca
    12841 ttcctctttt accttttcca tgcttaccat caccaggttt accagattta gcaagtgtaa
    12901 ggttcatgaa tgtaccatat tcctttactt ttccaactgt aagtttcatt attttcacct
    12961 cttttaaaaa ttataagact actccacttg tgttaaggtt tattattaca taaatgtaaa
    13021 catttacctt taaggtataa gtatagtaca cacccttata gaattcaaca tgaaattttt
    13081 acatcaatat agggtggtca tacaatattt tttattaagt atttcaattt ctacaacaaa
    13141 tattatttgg cggaaattaa aagtattaag ctttcttcat tcctctttta ccttttccat
    13201 gcttaccatc accaggttta ccagatttag caagtgtaag gttcatgaat gtaccatatt
    13261 cctttacttt tccaactgta agtttcatta ttttcacctc ctttaaaaat tataagacta
    13321 ctccacttgc gttgaggttt attattacat aaatgtaaac ttttaccttt acggtatgag
    13381 tatagtacat accctcgaaa aactcaatat aaaatatcta tacaatttta tttattaact
    13441 aggttaataa ataatttttt ttctaaagtt agactgacag aatttcagtc agctagtttt
    13501 ttaatattaa atatcttgat ttatttgttg cttaataccg ttcactacca atttcaaagc
    13561 gttgtaaaca agcgtcacaa agttaaaatg tacttttgct cgctttccag atcgatatcg
    13621 aacatttttc aactaagagc attcttttgg gtatgtgttc actcattcga tagcacttct
    13681 taatttttct atgcttctaa tctgctctag gacactatat ttccgaattt atggtgttat
    13741 gatagctgcc accaacgaaa aaattagtcc tgcaactctc caatataaag ttaattttcc
    13801 atttaattcc ttgattcagc atttcaaaat gcctttttat aatactttaa ttatattcta
    13861 aacattcaag taactttaat gtcaagtcct tccatttctg aattgcaaga ttattgagct
    13921 agaatctaag atttatattt attagaagac accctaatgt aatatttgaa cagtacctcg
    13981 aatcgtgata acttgaaaaa agtccatgat tcggggtact gttcatttga cggtttcctc
    14041 gtatttttaa aagcggtgcc tgaataacaa tataagagtg aagctgtttt ctaaaaacta
    14101 ttcggagttt ttagttaatt ttctatataa aaagtttcga atagtttttg aaatcaaaac
    14161 aaggatgctc attattttca gaggggtagt ggaatgttaa caaatatgaa gtattgtatc
    14221 tgatttaata cagactttgt catatacaat taaaacaata ttttttcatc taggggtcat
    14281 gctcatcaac ttaagaaatt ggttgtcccc aaaaacgaaa aaatgagcta aattctcata
    14341 aacaactgta aaatactaaa atttttattt tgaagaaact ttaacatact agtttgatgg
    14401 taatctggaa gacccaaaaa actcttttta cgaaatgaaa tttattcatc agtctgattc
    14461 gttttgtatt tatggtaaaa ttatgaataa gtactagtag gtaagttagt aagggtggtg
    14521 aacactaatg ggtgttttta cagctgtttt agtaacaggg tcaattttgt tccttgcatg
    14581 gaaagtagga aaaaggacag aaccaatgta aattcattag aatcttgttt taaaataaca
    14641 agattctttt ttattgtttt tagagtcgaa aaacttgctt atcagcttaa gagattttaa
    14701 taccctcaag tactaaaaaa cgttattctt tctaaacaaa ctagattgga aaggatgatg
    14761 ggcatggcct caccatatca aaaaaagaaa attgtacgtt tagacagatt tgtccagaaa
    14821 accctatctt attgaacagg gttattgact cctagcgtac aatttttcac ttttggtgat
    14881 gtgacaccta taatgtaaat atactttttt caaaggaggg atctaatgta tatatcaaac
    14941 agaattggct tatttagctg gattacaact tgcctatact ttctaattga acctttcttt
    15001 attttcactt ctacagtacc ttataactat ttgcatcatg caatgagtga tctaggtgta
    15061 acaacctgtg gaaaattcac ctatgaaata gctccttatg aaatatgctc tcctaatcat
    15121 ttttggatga atttactctt tattattaat ggattaacat tttgtattgg agtactatac
    15181 atttcacaac atctagaaaa aacaaaaatt aataaaatag caacattttt tatacttata
    15241 ataggagtct ccactatagt ttcaggatta attcctgcag atgtaaacct aattgggcat
    15301 tctattctag tttggatagg tatgcttact gtatacccag gattatttat ttttgctagg
    15361 aatcttaaaa aagctaaaaa atggacatat ttctgtttac taagcttaat attaataata
    15421 atccttatct cacttgtttt tcttttccct ttaccttcag gtctactaca aagacttttt
    15481 tatttagttc ttttcgtttg gggaactgta tcaacctaca aattaattaa ataaagaatt
    15541 tctgtacaaa acatgaaatt ttgtctaaac gtacaatttt ctttttttga tatggtgacc
    15601 cctaatagca aagtaaagta agattgcgat acttcgattt tattttttat ttgtttattt
    15661 tactcttttc aagagaagtt aatatatgag gtatcgccag cattttggaa aaaaacaagc
    15721 taagcaaaaa ataatataag ctgcctatat ggacagctca tttacataat tatcgaaagc
    15781 ggaagtaaat tatttgtcca aaaggttaac cgctcgcttg gaattagcat tgtttacttt
    15841 tcgaatatat aattcatatt aaagaacact tccaccaaat tatatttaga cttagttttt
    15901 tggtgattgc agcttatcaa ttttccagtg tgttgttcct agagagtcta aagagctttc
    15961 aatataaaac atatattcat ctgcggtacc tggtacttca aaagctattt tcaattctac
    16021 cgtttcattt ggtttaactt gtatatcaga agggttttgg tcaagcagct ttccttcata
    16081 cgtcttacca tttttttcat cttttaaggt atattttaat tctgatagtc caatcatttg
    16141 acctcgtaca ttttttacag agacattaac aacgatagaa tcgttgttat catttaaata
    16201 tgcactttga acggtggtca agtaatagcc tcccttagca ctctcaccaa ctaataaaat
    16261 accttgttcc aagcggctta tattttcttt ttcttcaaaa tttattaatt cttcattttc
    16321 attttttgcg gtgggttctt ctattgaatt attttcaact gcattatctt ttttatcttg
    16381 tgtgcaagca cccataacac tgacaaatac tagacttaaa gtaagtaata tggataattt
    16441 tctcataaat tttatcagtc tccttaaatt tctcaatttt gtgcaactgt aaatagattt
    16501 acccctaaac cgatcattac gaatgataga tttttattcc tgttttttgg taatgcaacc
    16561 ataagaaata aaaataatgc agtaccaatt ataagaaacg gtaatccaaa ataaaatcca
    16621 aaatataaaa taaattccat aatacccctc agaaattcaa attatatcat caataagggc
    16681 aattttggat aaatagaata taaatgctga gttaggggca tcactgcccc taactcccct
    16741 aagaaccgta cgtgacagtt tcccatcata cggctcaagc cttcttttta tccggtcaca
    16801 gtatcattgt aggcagggta agtggacgag tcgtgtattt ccattaggct gtaagtgact
    16861 ttgatgaatg ggcatatcct ttacaatgac cttttctcca ttttgcagag gacatttgca
    16921 tattgcacag cggtatcctt gttttctagc cagcttcatt ctatccattg tattctctag
    16981 gttgaaaacc ttacggtctc gcttctccca gtattccttg agagtagggt tgtcgggact
    17041 gtttttgtac ataaccataa cgtgtctttc aatctttatc cacggcatat gtagtagctg
    17101 aatatttgtc ttcggacagg ttggaaccca tacattccct ccatgatgcg gggctttata
    17161 gtatcgtgct ctaatccatt tccatgactt tttaggatgt aattgtctga gatgtttacg
    17221 taccttccag aatacatagt ttgctatctt gctaaatatc ctcttagaca ctacatgttt
    17281 ccaatattgt ccgtaacccc cgataattgg attcaatacc cgaataactt caccaatagg
    17341 ttgtcctttc atagtgcgaa atgtatctct aatcttctct ttagctttct gtatgccgct
    17401 cctacttggt ttaataaata atttatttcc tttccatgtc ttgtactgtc ggattgaaaa
    17461 tcctagaaac tcaaaacctc gctcgatgtg tgtaaccttc gttttttcta ggcttagttc
    17521 cagtcctcta tctttcagat agggacggag tctctcatat atggattggg cttgctcttt
    17581 tgtttccgct aggacgacaa aatcatctgc ataacgcaca agagctattt tacaagcggg
    17641 atggataatg tagcttccat tggctttgta attctttttg taagtgatac ctaatgcttc
    17701 ttccattcca tgaagtgcga cattagctaa taaaggtgag ataatccctc cttgtggagt
    17761 tccttcctgc gtctcagaga aagcatttcg ttccatgtac cccatttgaa gccatctttc
    17821 tataagttgg ctcccgggga aattggctaa ttgtttgagt atccaattat gattcagatg
    17881 gtcaaaacat cctttgaaat ttccttcaaa tatccatttc ttcttactac ccccgttaat
    17941 cctgttgaag atactacgta tggcatcatg tgtacttctt ttaggacgga aaccataaga
    18001 atttgcttca aatctagatt cccattgtgg ttctaatgcg tttctgacca tattttgata
    18061 tactctgtct tttattgtgg gaatacctaa aggtcttaac ttcccattct ttttggcgat
    18121 gtatatacgt ttcgctggtt tcggatgatg tcggaggata ttctgctttc taagttgctc
    18181 atataattga tttctttccc tccgacttaa cgctgtatgt tcatctactc caggtgttcg
    18241 ctttccttta ttctgttgcg tcacccttct aatggatatt attaagttcg cctcactcct
    18301 taggagtaaa cgttgaagtt ttcttacctt tctatgttga tttgactgtt cggcacgata
    18361 aattctttgt cgtaacttcg tcacatacat ttggactgct ttccaatccg ttgagttcca
    18421 ctctgtatac gagacgtgcg ccgacgctcg ttctgaggtg ttcataactg cacgctccta
    18481 ttcgtcagaa gataacttac agatatattt ccgtgttgaa gacctatagg aagtgggctc
    18541 tctttcgagc ttgtcatggg attgtccgtg aggacgacaa tatccgttca gttatacttg
    18601 ttgtttttct gttacctttc ggtacaacgg cattcgcttt ttcctatatc ctttaccctc
    18661 tgtcacatcg cttgacttta cagtctcact actgatttcc cagatgacat agggcttacc
    18721 aagtttcaca ttccacagat gcggtagggt taggtggact ctttactccg gacaaaatgc
    18781 gggacgcgac acggcagtgt tatgagcctg cctttccttt tgtcaatacc caagcaaggc
    18841 tgtacattat cttgggctaa tggttacgaa gcttgcaagt cttcactttc gttcaccata
    18901 cctatcttct cctagcagtt ttccagacca tgtactggtc gtttgtttcc gcatttcctc
    18961 atgcaaccca caagcctgtt accgagcttg cagtttcgga cggagatggt cttagcgtct
    19021 agactagtag cgaaagctac actgtaagaa tgcgacttct tgtcgcacca taacgtaaca
    19081 ttatcagaag ttctccttat caataatccc cgacttaaca acattctgtc aaacatcctc
    19141 tttccctacg tatgcagttt cttattcatc ccattatatc agtggttaaa agcaatcatt
    19201 atctttattt cctttattcc atatgtataa aattccgcat gaactaacgg ccagcttatg
    19261 cgttaataat taacacacgg ccaacttatg cttccgactc cgttgaataa ttagataatc
    19321 atctacaaaa agaagtgttt tttggccaat ttatgctttc aactgtggcc aacttatggg
    19381 taaagtgaca atggcctttt tagtgttgtc tatgagtata gttaattttc aaaacgaaag
    19441 aaagctgcat aatttttaaa aataataccc aactaggtgt atttagcgtg ctcactttta
    19501 aggataagta gtattttaaa aattttttag tttatttgaa caaaggttta ttttgttccc
    19561 attcttaaat tgatgggcat gggtcacacc atatcaaaaa agaaaattgt acgtttagac
    19621 acaattctga catgttttga ggtggatgct gtacgttaag atcatctttc ttattagatt
    19681 tatttttctt aataaaaaag gcaccctttc gagtgcctgc cactataagt catgttattt
    19741 taaataatat agactcaagt ttattggatt aataatttta taaattttga tagtagttac
    19801 aataaaatgt attaagtttt aaaacagctt gtaatacttt ttttggatca tctttttcaa
    19861 gcatttgtgt gattgctaaa taatataact tgtcatttaa ttggtttaat tttatggtca
    19921 ttcttaatcc tttaagttcg tttaacatta aatgatatct tttagcatcg tcaggattac
    19981 taggaatatt ttgttttata atacgctcac aatctagagc taaatttata aattcatgat
    20041 gatttttcat gtcatcctcc taataatttt ttattgtaac cagctgttat ctatcttatt
    20101 aatccagtat tgcatagctc caccttctct atattcttga actatacttg tacctttaag
    20161 atattgagtt tgagaagctg taaatccttt aagcattctc gtccctttag gtaccgtgat
    20221 tttatattgt atattgagcg gattccccca agcttctaat acggctaatt catttctagt
    20281 ttcttcaata tttctttctt tatctcccca ccaataacca agaccatatt tagattctgg
    20341 ttcaccagcc ttacttctcc tatataatgt aagtagcgta tcagtctcta taatttctat
    20401 ttttaattcc ttaaatgcta atacatctga ttttgtatct ttaaaatcaa aattagaaaa
    20461 tcctgaagaa cgtattacct ctctttttaa acttgctcgt tccattatac tcagatttaa
    20521 attatctatt ttatctaggg cctgattcat ttcttcaact ggccaattat tcaaatcact
    20581 atttctaata tagctgattt tttctcctag attagtatta tcattaaaaa caatagtcat
    20641 ttgctcaata ttgcttaaat tgatgttttt ttcctgtgca tatgtaacgg ataaaggaaa
    20701 ataaaccatt aataaaatca acatgattat actagcaaaa tactttctca tacttaattc
    20761 tgtcccctta tatgaatcta tttttagtta tttcaattgg aaataaaatc taatttcctt
    20821 aaaatatatt tccataccgg ttcttctcct gtaatgacag aagctctacc aaccatccct
    20881 gtatgtagtt cttgtaattc ttttgtatca attgtggctt ctagttcata catataccct
    20941 ttcgtatttt tatcaaaagt aggatatgct gatacatatg ttatctgtcc catttgttta
    21001 tccgttttct gtaacttaaa cgaatattgt actttatctc ctttttttat tccttttatc
    21061 tcttgagctg gtaataagat tcttactttt ttttgttctt cttttgggat aattgaaaca
    21121 atctcttggc caggattaat taaatcccct tgttgtaaga tggaaggaaa ttgtacaatc
    21181 ccgttttttt gtgcttttat gattgtcgtt tcattttgat gacgcagtcc atctaactct
    21241 tgctttttaa taaatagttc ttgttctagg gattgaatac gttgattcac tgaaatcata
    21301 tactcttctt tatattgatt taaagcatct ttcttttgtt cttgctttcc ttctttagta
    21361 acatcaactt ttgttctttc atgctctaaa gtttcttttc gttgctggat acgcttttct
    21421 acactgtttt gttgagattc taaattccct attttatcat tcattacttg tttttgatct
    21481 tctaatatat tttcttttgt tttttgtttt tcaattgtgt ctatttctct ttggatattt
    21541 tccttttctg caattagccc ttgtaaaact tcatcttgtt cgtttgaaaa tttgccatgc
    21601 tctatttttt ttatttcatt gtcattttca ttttgtatag attgatatct ttgatcataa
    21661 gcctgatatt cttctcttat ttttttatcc acatcatcag gaaaagagga tttatgagac
    21721 cggatactct ctttcaactg ctctagcatc cctttttgtt tttctaaatg ttctacaatt
    21781 tgattcacct gattttgttt atctgttaat tcttgatttt ttaattgaat taaaatatct
    21841 ccttttttta cttcatcacc agacttaaca gcaaccatat caaccacacc tacaatttga
    21901 gtacgagaca cacttgcatc tgattttcct tgtatcattg ccgttccctt acttacaata
    21961 tctatcttgc tgacataagc ccaaattaaa aaagtaaata aactcatcaa aagaaaaacg
    22021 agtaatccag caataaaacg aggaggcttt ctttccaata attccacact atccgttaat
    22081 tgatcaaaag aatagatttt actcatattg gttatctccc attacatatg attgcgattc
    22141 tatatgttcg acatggaccg tttgattctt ccaaagacga taatactcac ccttatagaa
    22201 taataattcc tcatgagagc cacgctctat aatatttcct ttttccatta caaaaatttg
    22261 gcttgcatgt tgaattgtac tcaatctatg agcaatcata atcacggtta ctccttgtga
    22321 acctaattct tttaacatat ctgtaatatg tttttcagtt gtagaatcta aattacttgt
    22381 agcttcatct aatattaaaa tgtctggttt ttttaataac gctcttgcaa ttgctaagcg
    22441 ttgtctttgg ccaccagata aatttgatgc attttcttct aaaaaagttt cataacgtaa
    22501 tggcaactca ctaataaact catgtacaca agcttgctta catacttgta taacttcttc
    22561 caaagtaact ttttgttcta agccaaaaca taaattttca taaatagaag cactaaagaa
    22621 aaatgattct tgagaaacat atgcaattcg atctcgtagt gcagtacgat ttatctcttt
    22681 aacatggtaa tcatcataat atatatcccc ttgttgcgat tcataataat gcattaataa
    22741 ttttgaaatt gttgtttttc cagaaccact ttcccccaca aaagctgctt gactacctgg
    22801 ttcaatggaa aaacttatat tatttaaaac attcttgcgt gttccataac gaaatgtaac
    22861 atttgagcat tcaatcttac ctgataattg tttaggagat accttattat cctctttttc
    22921 acttttttct tgatctaaat caaaaatttc atttaatctt tctccagcaa ctaatgcaga
    22981 ttgcatagta ggttgaattc cgattaaatt ttcaattgga tttaaaaaat aagctaagag
    23041 tgcattatat gtaattaatt cacctattgt catatttcct tttaatactt gcatagcacc
    23101 aatccaaaga ataaccgtcc ctccaattaa ctcaagtcca atcttaatag aaacttgcaa
    23161 attagatagc attcctcttt taaatacatg ctttaataaa ttaacaaaac gactttcagt
    23221 ttgaaaaaac acttcttttt cagcgttata agactttata gttgcaatcc catttaaaga
    23281 ttctactaaa taagaattca actttgcatt actctccatt tcttctctat taatagattg
    23341 atatggctta tgaaaggcaa aaataatacc tatataaaaa ggtattaata ataaagtaaa
    23401 accaaataaa actggactat gtatatataa taaaatagcg cctaatgtca ccattactgt
    23461 atcaatcatt aatgtcactg ttattgttga taaagcatct cttattttac ttgcatccat
    23521 aaatcgagaa ataatttctc ctatttttct tgtttcaaaa aaatttatcg gtaatcccac
    23581 aacatggcga taatacccta gcattaattg aatatcgatt cgtctgctta aatataagat
    23641 caaatgcgta cgaaaataag aaagaagtac cttaaagata tacaatataa taattccaat
    23701 tgatacaata tgaagcgtct gtaacaactg attcgtcaca atatcatcaa ttaaaaattt
    23761 aaaataaaaa gctcccaata atccaaataa attaaagaaa atagaagcaa aaaataaagg
    23821 tactaataaa ttagtttgtt gtttcagtaa aaataaaaaa cgagaaagtg tactttgtaa
    23881 tgccttacct ttttggaaat tctcagtagg tgtcataaga actagaatgc cagtccatat
    23941 ttggccgaac tcttctaata aatatgtgac aaatcctttc tcaggatctg caatataaat
    24001 tttattattt ttaactttat aaattactac ataatgaagt aaccctcctc ccatcactac
    24061 atgtgcaata gcaggtaagg tgattttttc taatgcttca aaatttgtag cttttacccc
    24121 ttttactcca aaacctaatt tctctccagc ttctattaag ccttttatat tagttccttc
    24181 taaatctgta cctgctattt ctctaatttt tgatatagac atagtaaaac cataataacg
    24241 agaaatcatt gcaaggcatg ctggcccaca atcttttaaa tcctgttgtt taatacaagt
    24301 gaactttttt ttaaacacaa tcacagcctc ttctctttac attcgtatat ataatttaat
    24361 tatatataaa aatataaaaa aaggatgaaa tatgcaattt tacatattaa accctttttt
    24421 aggggattta tgatatttta gatataacga ttgttatatt ttgattcata tataaaacga
    24481 ttgaatcata taaaacaatc taaaattata tattaaaggg gaataacatt atgaaaatca
    24541 atgaaatgac agaacaactt acagaaaaag agcttctaga aatctcagca ggtggaagct
    24601 gccttaataa aattggagca ggcgttgtta aaggtatctt cgcaggtggt gctgctggtg
    24661 ctgctgcaac aatgggatta ggtacagcag gtggcgcatt tgttggagct catattggag
    24721 ctgctgctgg agcaattact tgtcttggag aataaaaaat aaaaggactg atataaatga
    24781 aagaaattaa taacacactt acaaaattat cagaagaaga attagaaaac atcaatggtg
    24841 gaggctgcac ttggaaaaaa gctgctgctg aagctgctgg tggaattatc atcggttcta
    24901 tgggaggtcc atggggcgct ctaggtggcg gagtaacagg cgttgcatta tgctatttaa
    24961 atgattaagt aatataagta aatcccccnn gggggattta cttatattac agaaaataaa
    25021 atttaatata attcagctaa taaaaataaa agtcaataac aatcatttga catttataca
    25081 ggtaacaatg taatatataa attacattaa ggcatattta tattccatta gggggaatct
    25141 tatattgaat ataaaaatga aattaacacg tattgaaaaa ggtttaacac aaaaacaact
    25201 tgctgactta gttaatgtaa gtagacaaac cattggatta attgaaaaag aagaatataa
    25261 tccatcatta aaactctgtt tgtctatttg tatagcctta gacaaaacat taaacgattt
    25321 attttgggaa ggagaaataa aatgaaaaca attatagaaa aaatactctt aggtcaaaaa
    25381 tcaaatgatg agtatcaaga aaaagcatat acaaaatata tagcagaagc aggtatttta
    25441 gttatgttaa taaatttttt atacttgact acaaaaacta tatatctgaa agaaatttct
    25501 acagatatta ttgtttgctt aacattattt ttaatttttt gtggatatat aactattaga
    25561 atttttaaaa gtaacattga tttcattaat attacttcag agacagactt agaaaaaaac
    25621 aaaaagaagc ttttaaaaaa tacaatttta caaagtataa tcttttttat tgtttttagt
    25681 ggatcaggtt atgtcataga tagtccttct tcatggactt taaatataat tactagtata
    25741 tttttcggta tagcaatcta cttaataaat aagacaaatg ctaaaaaatc tttaaaaatg
    25801 aataatgaat taaatgatta atctatttat ctagctatat aattgaaaaa aaggaggggt
    25861 atttatcatt aatagtaaat caccattcag aaaaaaattc ctgttcctct ttatatttat
    25921 cttcccagca gttttattta aattctttga ggatagagat ttagtcacag ctgtaaaaaa
    25981 tttaatttta ctatcattaa taagttttgt tataatcttt attgttgata caatatcaaa
    26041 tttagtaaac aagtatgata aacacaaaaa gtgattgaat cagaggtatt gtttacacat
    26101 tagtgaaaat ataggtgaat taaaattcga cataaaaaga gctagatttc ctactttaag
    26161 gaatattcgg ctcttttgtt gtatttaggt tataatgtgt tttttttatt ctttaattat
    26221 tctataaaag gttctggtgc aaaaacttca ggacaattgc aataaatctt ggacatactg
    26281 atattactaa tctaaagaag gtgcgtgatt ggtatggaaa aggaaaatgt atttaaatgg
    26341 aaacattatc agcctgatat tattttgtta acggtaagat ggtacctacg gtacaacctc
    26401 agttttcgtg atttagtgga aatgatggcg gaacggtttt tatccatttc tcatacaacg
    26461 attatgcgtt gggttcatca gtacggtcct gaattggaca aacgaatccg acgtcacctt
    26521 aaacaaacaa atgactc
//
