LOCUS       NZ_NUIO01000070        25239 bp    DNA     linear   CON 20-MAY-2024
DEFINITION  Bacillus thuringiensis strain AFS049207
            AFS049207_100_C7_Contig31_140514, whole genome shotgun sequence.
ACCESSION   NZ_NUIO01000070
VERSION     NZ_NUIO01000070.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus thuringiensis
  ORGANISM  Bacillus thuringiensis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 137818)
  AUTHORS   Bleich,R.M., Grubbs,K.J., Santa Maria,K.C., Allen,S.E., Farag,S.,
            Shank,E.A. and Bowers,A.
  CONSRTM   Agbiome Team Llc
  TITLE     Large-scale bioinformatics analysis of Bacillus genomes uncovers
            conserved roles of natural products in bacterial physiology
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 137818)
  AUTHORS   Bleich,R.M., Grubbs,K.J., Santa Maria,K.C., Allen,S.E., Farag,S.,
            Shank,E.A. and Bowers,A.
  CONSRTM   Agbiome Team Llc
  TITLE     Direct Submission
  JOURNAL   Submitted (07-SEP-2017) Chemical Biology and Medicinal Chemistry,
            UNC Chapel Hill, 125 Mason Farm Rd., Chapel Hill, NC 17599, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Assembly Cell v. 4.2.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.45x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002575705.1-RS_2024_05_20
            Annotation Date                   :: 05/20/2024 01:16:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,769
            CDSs (total)                      :: 5,694
            Genes (coding)                    :: 5,513
            CDSs (with protein)               :: 5,513
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 182
            CDSs (without protein)            :: 181
            Pseudo Genes (ambiguous residues) :: 0 of 182
            Pseudo Genes (frameshifted)       :: 72 of 182
            Pseudo Genes (incomplete)         :: 113 of 182
            Pseudo Genes (internal stop)      :: 64 of 182
            Pseudo Genes (multiple problems)  :: 54 of 182
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:44:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 14720
            Orig. end                         :: 39959
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NUIO01000070.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25239
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25239
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25239
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15239](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15239
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            297..1223
                     /gene="bla"
                     /locus_tag="CN977_RS24455"
                     /old_locus_tag="CN977_24455"
     CDS             297..1223
                     /EC_number="3.5.2.6"
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="bla"
                     /gene_functions="resistance (resist) ClassA"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002101021.1"
                     /locus_tag="CN977_RS24455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24455"
                     /product="class A beta-lactamase Bla1"
                     /protein_id="WP_142338674.1"
                     /transl_table=11
                     /translation="MILKNKRMLKIGICVGILGLSITSLEAFTGGALQVEAKEKTGQVK
                     HKNQATHKEFSQLEKKFDARLGVYAIDTGTNQTISYRPNERFAFASTYKALAAGVLLQQ
                     NSIDTLNEVITFTKEDLVDYSPVTEKHVDTGMKLGEIAEVAVRSSDNTAGNILFNKIGG
                     PKGYEKALRHMGDRITMSDRFETELNEAIPGDIRDTSTAKAIATNLKAFTVGNALPAEK
                     RKILTEWMKGNATGDKLIRAGVPTDWVVGDKSGAGSYGTRNDIAIVWPPNRAPIIIAIL
                     SSKDEKEATYDNQLIAEATEVIVKALR"
     gene            1484..2326
                     /locus_tag="CN977_RS24460"
                     /old_locus_tag="CN977_24460"
     CDS             1484..2326
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="CN977_RS24460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24460"
                     /product="metallophosphoesterase"
                     /protein_id="WP_000727189.1"
                     /sec_met_domain="Metallophos_2 (E-value: 2.2e-09, bitscore:
                     30.8, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKINRIVMIICILVGFTIFLYLQNNLISITEVKITSSKIPSSF
                     KGYKILQISDLHNKKFGDNQDVLIQKIKSIDPDIIAITGDLIDSKSYDAEVSMQLIREI
                     VKKYPVYFVTGNHEQWSGKYNNLEKELKKYDVNVLRNEHVGIRKGEQEINLLGIDDPEF
                     VTGNRDEGNIIIDEIKKAKIEMQPDKYNVLLSHRPEFIKEYTNERLDLVLSGHAHGGQV
                     RLPFIGGLVAPNQGVLPKYTAGLYVEQNTSMVVSRGLGNSIIPQRILNRPEIVVVQLN"
     gene            2541..2792
                     /locus_tag="CN977_RS24465"
                     /old_locus_tag="CN977_24465"
     CDS             2541..2792
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="CN977_RS24465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24465"
                     /product="hypothetical protein"
                     /protein_id="WP_000548621.1"
                     /transl_table=11
                     /translation="MHKEYEIEEYTAIEEQIHYYCKCLLVSHPDQIIKYLEKRLEKYAE
                     TLQYAHLYPDTVILPLQQLVIEYSLDVARIRKYMNLKT"
     gene            2980..3705
                     /locus_tag="CN977_RS24470"
                     /old_locus_tag="CN977_24470"
     CDS             2980..3705
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001187059.1"
                     /locus_tag="CN977_RS24470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24470"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_001187074.1"
                     /transl_table=11
                     /translation="MQQPSIILRTVSKSFGKKEVLHNLSLQVEKAEIFGFVGPSGSGKT
                     TLIKMIAGINEATKGEVLVNNTNMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKSKKTRIAEVFELVQLSQYMKKQVQQFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKTIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGKLVAVGTTEELKK
                     RVSSGRIEDVFLLEEVVPS"
     gene            3702..4721
                     /locus_tag="CN977_RS24475"
                     /old_locus_tag="CN977_24475"
     CDS             3702..4721
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="CN977_RS24475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24475"
                     /product="ABC transporter permease"
                     /protein_id="WP_001266715.1"
                     /transl_table=11
                     /translation="MRVTGVIIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLVFTQKDYI
                     PQIAVVDMPAQIVKMMKNQEASIYEYSKEKAISELEKQKVDAVFRIENGKMKLLLEGSD
                     SSKNRAVLQVLQKSTEKNDVSIMKPEVNYLHGSKDFTMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVAGYIIGFGIFAFIQSIIIVSFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQIFFSGLFPLESMNKW
                     LQMLGKVFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSILFAVGNVFALKKHRKI"
     gene            4746..5399
                     /locus_tag="CN977_RS24480"
                     /old_locus_tag="CN977_24480"
     CDS             4746..5399
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168192.1"
                     /locus_tag="CN977_RS24480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24480"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_001168192.1"
                     /transl_table=11
                     /translation="MQKDWLEELIAATNTDKRNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLLAVVMPTLTKFAAPFFVQTFAKEIFKSEYESYEGLL
                     RVVIHNRFKFAQKHFPMIKILIQEVPFQPELKNEIQQLVETELFSHFKKLIVKFQEEGE
                     IIEIPPSSVLRLTLSAVLGLLLTRFLLLPEEKWNDEAEIENTIQFILYGLTPRI"
     gene            complement(5521..5820)
                     /locus_tag="CN977_RS24485"
                     /old_locus_tag="CN977_24485"
     CDS             complement(5521..5820)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728146.1"
                     /locus_tag="CN977_RS24485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24485"
                     /product="WGxxGxxG family protein"
                     /protein_id="WP_000728159.1"
                     /transl_table=11
                     /translation="MKKKLSSILSVLTLSIMFLGTSTQAEYDGNNMNRVNNTDISTRVN
                     DNNLDRVNNDVRTRNVNTTNDLNDNRDKNNNWAWLGLLGLAGLLGLRRRDKETR"
     gene            6054..7022
                     /locus_tag="CN977_RS24490"
                     /old_locus_tag="CN977_24490"
     CDS             6054..7022
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="CN977_RS24490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24490"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_001248638.1"
                     /transl_table=11
                     /translation="MRQFAKPTIVVSKCLEFDACRYNGEMIPDVTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEENGENRLVQPSTREDVTEKMEQFSNDFLQTIPDVDGFILKN
                     RSPSCGTRDVKIYSGFEKAPAKGKGAGLFGGAVVKKFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAYYKMIKHNKNMKELVSFQSDNKYLFMAYNQVKQKELGRIIANQKNEKIEVVFE
                     NYEKTLYELFMRAPRYTSNVNVCEHIFGYFKTKLKKQEKDHFIELLQKYAEKKIPLSSL
                     LTILKSWAIRFDEKYLLRQTYFEPYPEALVEISDSGKGRDY"
     gene            7239..8384
                     /locus_tag="CN977_RS24495"
                     /old_locus_tag="CN977_24495"
     CDS             7239..8384
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="CN977_RS24495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24495"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_000397282.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 4.8e-41, bitscore:
                     133.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.2e-27, bitscore:
                     89.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2e-58, bitscore:
                     190.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAVLDGDEYVISGEKCWITNAEYA
                     NTIIVTAVNGVEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANQAVQIHG
                     GYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            8400..9737
                     /locus_tag="CN977_RS24500"
                     /old_locus_tag="CN977_24500"
     CDS             8400..9737
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="CN977_RS24500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24500"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_000486743.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 7.1e-12,
                     bitscore: 38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 9.5e-08, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 7.9e-08, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 1.3e-10, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIASGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITNLTLPSNVRIDHFLENHVTITPFYDPMIAKVIAHGETREEAISK
                     LHDALEELKVEGIKTNTPMLLQVLEDEVFKEGIYTTGFVTKQLVKK"
     gene            9764..9979
                     /locus_tag="CN977_RS24505"
                     /old_locus_tag="CN977_24505"
     CDS             9764..9979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="CN977_RS24505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24505"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001987345.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIISE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            10001..10912
                     /gene="mvaB"
                     /locus_tag="CN977_RS24510"
                     /old_locus_tag="CN977_24510"
     CDS             10001..10912
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="CN977_RS24510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24510"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_000775428.1"
                     /sec_met_domain="HMGL-like (E-value: 5.9e-49, bitscore:
                     160.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISATAVDELC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGITTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            10917..11705
                     /locus_tag="CN977_RS24515"
                     /old_locus_tag="CN977_24515"
     CDS             10917..11705
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 1.5e-75. Score:
                     245.6. Matches aSDomain:
                     nrpspksdomains_CN977_RS24515_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="CN977_RS24515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24515"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_000939799.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLNRARQANSLSLALLDELQTILTQI
                     SEDSSARVVILTGAGEKAFCAGADLKERADMNEEQVRHAVSMIRTTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRIEGLQAFKEKRKPMYKGE"
     aSDomain        10959..11678
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CN977_RS24515_ECH.1"
                     /evalue="1.50E-75"
                     /label="CN977_RS24515_ECH.1"
                     /locus_tag="CN977_RS24515"
                     /protein_end="254"
                     /protein_start="14"
                     /score="245.6"
                     /tool="antismash"
                     /translation="HVVKISLNRARQANSLSLALLDELQTILTQISEDSSARVVILTGA
                     GEKAFCAGADLKERADMNEEQVRHAVSMIRTTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRIEGLQAFKEK"
     gene            11708..13249
                     /locus_tag="CN977_RS24520"
                     /old_locus_tag="CN977_24520"
     CDS             11708..13249
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094296.1"
                     /locus_tag="CN977_RS24520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24520"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_000886744.1"
                     /transl_table=11
                     /translation="MLDQKQQSNSFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGSRTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVCLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNM
                     KDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYHLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            13299..15239
                     /locus_tag="CN977_RS24525"
                     /old_locus_tag="CN977_24525"
     CDS             13299..15239
                     /NRPS_PKS="Domain: AMP-binding (99-521). E-value: 4e-82.
                     Score: 267.9. Matches aSDomain:
                     nrpspksdomains_CN977_RS24525_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="CN977_RS24525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24525"
                     /product="AMP-binding protein"
                     /protein_id="WP_098829706.1"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-89, bitscore:
                     293.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFW
                     GEAEKAVGYQWMKPYTEVLDLENGTPFAQWYNGGTCNVVESALSRWLADEETRIQPALQ
                     YEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDKYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDKVKGEVCHCFVVLRDHVTFTGELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     aSDomain        13596..14861
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CN977_RS24525_AMP-binding.1"
                     /evalue="4.00E-82"
                     /label="CN977_RS24525_AMP-binding.1"
                     /locus_tag="CN977_RS24525"
                     /protein_end="521"
                     /protein_start="99"
                     /score="267.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QPALQYEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTI
                     YMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIV
                     SLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPL
                     MLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFG
                     SLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDKYVNKHSLK
                     SLEVFASTGEPWNPDPWMWLFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFN
                     ASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVH
                     GDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       14085..14141
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CN977_RS24525_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="CN977_RS24525"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     CDS_motif       14832..14894
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CN977_RS24525_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="CN977_RS24525"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     assembly_gap    15254..15266
                     /estimated_length=13
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(15554..15886)
                     /locus_tag="CN977_RS24530"
                     /old_locus_tag="CN977_24530"
     CDS             complement(15554..15886)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CN977_RS24530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CN977_24530"
                     /product="hypothetical protein"
                     /protein_id="WP_098829707.1"
                     /transl_table=11
                     /translation="MIAGVLRKSIVVMIGGNLKKSIIVMMIGVLRKSIVMMIGGNLKKS
                     VIVMMIGVLNEISVVVNVSLFVAIVKEKIGNLFNINVKERIWLLEPIGLFRKVNPTPTS
                     LLSLNF"
     gene            16485..16841
                     /locus_tag="CN977_RS24535"
                     /old_locus_tag="CN977_24535"
     CDS             16485..16841
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000535569.1"
                     /locus_tag="CN977_RS24535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24535"
                     /product="hypothetical protein"
                     /protein_id="WP_000535572.1"
                     /transl_table=11
                     /translation="MGSRFNNCKKKCTCKQDDCWEVFEECKKEQHEKCDNSCVQGIRDE
                     LKKLINRTVQINTEGRTYVGTVSSVSCDLVRLAAIPGSVGVIISICKIEAIFPPVTTVT
                     ADFDFNGIDVANKA"
     misc_feature    16856..16871
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     gene            16947..17480
                     /locus_tag="CN977_RS24540"
                     /old_locus_tag="CN977_24540"
     CDS             16947..17480
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002007691.1"
                     /locus_tag="CN977_RS24540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24540"
                     /product="GNAT family protein"
                     /protein_id="WP_000990084.1"
                     /transl_table=11
                     /translation="MMYERSKEVIKLESFKKSDFKQLINWINSEEFLIQWSGNAFTFPL
                     DEQQLEKYIESANTLAFKVVDEVTSDVIGHISLGQIDNINKSARIGKVLVGNTKMRGRS
                     IGKHMMKAVLHIAFDELKLHRVTLGVYDFNTSAIFCYEKIGFVKEGLLRESKRVGETYW
                     NLWEMSMLEYEWKK"
     gene            complement(17752..18360)
                     /locus_tag="CN977_RS24545"
                     /old_locus_tag="CN977_24545"
     CDS             complement(17752..18360)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000807974.1"
                     /locus_tag="CN977_RS24545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24545"
                     /product="hypothetical protein"
                     /protein_id="WP_000136050.1"
                     /transl_table=11
                     /translation="MTEIKVGLTQFLDFTLKGSTAKTNFIKNLKSQPEYQPAFDYWKQL
                     RETVIKFHQNKLPFECFETLVQTVDQKKKQNYIDVIKQYKKFIKNKDISWFDPGKSHWK
                     SDDLIVRSSPELGLFINNEPHLIKLFFKGKKERIDKYNINSTLTLLNESTFSNERNDVN
                     YTVLNIQKNRMYTNNSINNNHLVALKSEANQFCYIWNNL"
     gene            complement(18969..19106)
                     /locus_tag="CN977_RS24550"
                     /old_locus_tag="CN977_24550"
     CDS             complement(18969..19106)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376553.1"
                     /locus_tag="CN977_RS24550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24550"
                     /product="DUF3956 domain-containing protein"
                     /protein_id="WP_000376554.1"
                     /transl_table=11
                     /translation="MDSCVVFVNGQPFLVLSVAGIEIARLEISLQVALALRVLGIPICD
                     "
     gene            <19288..19377
                     /locus_tag="CN977_RS24555"
                     /old_locus_tag="CN977_24555"
                     /pseudo=""
     CDS             <19288..19377
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288863.1"
                     /locus_tag="CN977_RS24555"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24555"
                     /product="DNA damage-inducible protein DinB"
                     /pseudo=""
                     /transl_table=11
                     /translation="YEIHHIGQLSIWARQLNLQPVSANLIGRG"
     gene            complement(19439..20455)
                     /locus_tag="CN977_RS24560"
                     /old_locus_tag="CN977_24560"
     CDS             complement(19439..20455)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="CN977_RS24560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24560"
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_086391150.1"
                     /transl_table=11
                     /translation="MQFLKKFAILLLSFFITALIVLYFYLYVNGPIIQAKSAILINANS
                     GEIVYKKNEETPVQSAALSKLMTEYIVLEQLNDRKIQLDDFVQISNEVFRVETSPIQVT
                     SNDKTTVRDLLHALLLAGNNRSALALAEHIAGNEDNFTVLMNKKAKELKLLQPSPFLNS
                     TGINNDTNKQSTTTAIDAAKLAARLIKDFPDVLNITKLTSYQFSFKDSQVFNTNKMIYS
                     LNENIKLQGVDGLQTSFSTNGNYSFVSTAKLEDTRLISVILDADEENISFIETKKLLQY
                     GFDPSSYSALQAFKDTLTSWTILLQFKNLIIQTIMIFLIITTLMFLHIRQKKSEDFN"
     gene            complement(20631..21788)
                     /locus_tag="CN977_RS24565"
                     /old_locus_tag="CN977_24565"
     CDS             complement(20631..21788)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001243314.1"
                     /locus_tag="CN977_RS24565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24565"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_001243314.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIYRLVTSVIES
                     SLTLTELGKEFIRIFGYEKYKGVKESLWMMIVSYLFLFSIFSSYLYIFYRHERKLYYET
                     CIKKMIEEIRYIANGNFNHKVSVVNHNYLEELAIGVNEIVEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRYYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSVPIDIVELLGQLTVQFRIQVQEANIECRPSFPSQKLMVLADGDKLVRV
                     FENLIINAIAYGSEGRYIDLTAYESNNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDEKTTFTVKLLPYKG"
     gene            complement(21778..22473)
                     /locus_tag="CN977_RS24570"
                     /old_locus_tag="CN977_24570"
     CDS             complement(21778..22473)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanR"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038809.1"
                     /locus_tag="CN977_RS24570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24570"
                     /product="response regulator transcription factor"
                     /protein_id="WP_001038808.1"
                     /transl_table=11
                     /translation="MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQKVSTY
                     EVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVMNGEKFIHTV
                     WGVGYKIEK"
     gene            22666..23273
                     /gene="yqeK"
                     /locus_tag="CN977_RS24575"
                     /old_locus_tag="CN977_24575"
                     /pseudo=""
     CDS             22666..23273
                     /codon_start=1
                     /gene="yqeK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000965880.1"
                     /locus_tag="CN977_RS24575"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24575"
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLYNDIYSFAPTGKIDNDIKDFLLKYNKEFTYKHSIRVANEAKKI
                     AEKFHVDKEKAAIAGYLHDISGIFPNEERIAVAEEFGVEIEEAERKFPMIIHQKLSRVI
                     AKEIFKVEDEDVLDAICCHTTLRKHPTKMDLVLFVADKIEWDQKGTPPYLIEIKKDWKN
                     LWKKLLLYIFHICGKGKIH"
     gene            23287..>23658
                     /locus_tag="CN977_RS24580"
                     /old_locus_tag="CN977_24580"
                     /pseudo=""
     CDS             23287..>23658
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002110027.1"
                     /locus_tag="CN977_RS24580"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24580"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQLKEYMNQTFPGVTLVPYLYSQWGNHLYFDFGKDKYQIVEGTDD
                     LNMEYFSQLYTYNKFLFEDIFSKEDVVFVVTNVYRFKKENTKTPQKINVYNKYIKKRDL
                     RFHIRQETLPFLFEDEEADL"
     misc_feature    complement(23724..23738)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.69"
                     /tool="antismash"
     misc_feature    23726..23740
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            <23800..24105
                     /locus_tag="CN977_RS30075"
                     /pseudo=""
     CDS             <23800..24105
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002156408.1"
                     /locus_tag="CN977_RS30075"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF3885 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="LYCTYQFSLKCLAEDIKYESLIQAANHEDFSILYPRFGRKKEISY
                     PDVFLINATKDIVMFMYDDRGCEVIAKNKEIIRDLYKKYKEWIPDYERESIDNLFK"
     gene            24102..24839
                     /locus_tag="CN977_RS24590"
                     /old_locus_tag="CN977_24590"
     CDS             24102..24839
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129475.1"
                     /locus_tag="CN977_RS24590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN977_24590"
                     /product="S-adenosylhomocysteine nucleosidase"
                     /protein_id="WP_002082744.1"
                     /transl_table=11
                     /translation="MTIGEVKRVMKRIAIVSAWEPELTYLHQHYPSERVEKRAAWEFHF
                     HTINELEIISVVTGVGKVSCASCVQLLISEFQPDELFMTGICGSLSNKVKNGHIVVALN
                     AIQHDVTAAGSGEDVFNLYNGRTAPIETTKSLVRRIKKIRLYDPIHFGTFLSGDQRIRS
                     SEMRYLLHTVYGALAVDQEVAAFAYVCQINKKPFLCLKAASDQANDKTKEEQKIFKMLA
                     CERACEHLIAFLRVYEINVVNNR"
ORIGIN
        1 attagatgta tactttgatt taaaacagca acgcatacat ggtgaagcta ctagtacagg
       61 tagttctaag caaaattaga gtacttttct cagggaaaga ccctgttcat ataaagccat
      121 ttataagtaa aaaaatgaaa tatgaaataa gagatagagg cgtcgtagct actatctctt
      181 attttgttaa taactctcat actagctata atttttttag tttatggaac aaatttggtt
      241 cggtgattgt ctattatgtg tacgtataaa aaggtgctaa aaatttggaa ggaatgatga
      301 ttttgaaaaa taagaggatg ctaaaaatag gaatatgcgt tggtatatta ggtttaagta
      361 ttacaagcct agaagctttt acaggagggg cactgcaagt tgaagcgaaa gaaaagactg
      421 gacaagtgaa acataaaaat caggcgacgc ataaagagtt ctctcaactt gagaaaaaat
      481 ttgatgctcg attaggtgta tatgcgattg atactggtac aaatcaaaca atctcttatc
      541 gacctaacga aagatttgcc ttcgcatcaa cctacaaggc tttagctgca ggagtattac
      601 tacagcaaaa ctcaattgat acattaaatg aagtaatcac atttacgaaa gaagacttag
      661 tggattattc acctgttaca gagaaacatg tagatactgg aatgaaacta ggagaaattg
      721 ctgaggttgc tgttcgttca agtgataata ctgcagggaa cattttattt aataaaatag
      781 gcggaccgaa aggatatgaa aaagcgctta ggcatatggg ggatcggatt actatgtctg
      841 atcgctttga aacagaatta aacgaagcta ttccaggaga cattcgtgac actagtacag
      901 cgaaagctat tgctacgaat cttaaagctt ttacggtcgg aaatgcactt ccagctgaaa
      961 aacgtaaaat tcttacagag tggatgaaag gaaatgctac aggggacaaa cttattcgtg
     1021 caggcgtacc aactgactgg gtagttggag ataaatcagg tgctggtagt tacgggacaa
     1081 gaaatgatat tgctatcgtt tggcctccaa atagagcacc aattatcatc gcaattttat
     1141 ctagtaaaga tgagaaagag gctacctatg ataatcaact cattgcagag gcaactgaag
     1201 ttatagttaa ggctcttagg taatagtatt ttagttttcg catttttaac ataaaagtat
     1261 taaaagtata aagttagaaa acgactcttt tcgtgtgata agagtcgttt ttgtgttctt
     1321 attattaaaa aggtaaaagt aaaaatataa cgaatatata tgacgtatct catatgaaat
     1381 tttatgtact gtattatttt attaatttaa ataaatttca agaaagtata atataattca
     1441 gttagcatat agaagtgttt gatgagaata taaaggagaa aatatgaaaa aaaagattaa
     1501 tagaatcgta atgattattt gtatattagt aggttttaca atctttttat atttacagaa
     1561 caatttaata agtataactg aggttaaaat aacctctagt aaaataccat cctcttttaa
     1621 agggtataaa attctacaaa tttcagactt acacaataaa aaatttggcg ataatcaaga
     1681 tgtgttaatt caaaaaataa aaagtataga cccagatatt attgcgatta cgggtgattt
     1741 aattgacagt aaatcatacg atgcagaagt tagtatgcaa ttaatacgag aaattgtaaa
     1801 gaagtatcct gtatattttg tgacaggaaa ccatgaacaa tggtctggaa agtataacaa
     1861 tttagaaaaa gagttgaaga aatatgatgt caatgtttta aggaatgaac atgtaggcat
     1921 tcgaaagggt gagcaagaaa taaacttgct aggtattgat gatccagagt ttgttactgg
     1981 aaaccgtgat gaaggaaata ttataataga tgaaattaaa aaagcgaaaa ttgaaatgca
     2041 gccagataaa tataatgtat tattatccca tcggcctgaa tttataaagg aatatacgaa
     2101 tgagaggttg gatttggttt tatcgggaca tgctcatgga gggcaagtta gattgccatt
     2161 tatcggtgga ttagttgcgc caaatcaagg tgttttacct aaatatacag caggtttata
     2221 tgtagaacaa aatacatcaa tggtagtgag tagaggatta ggaaatagta tcattccgca
     2281 aagaattttg aataggccag agattgtagt cgtgcagcta aattaagctg tacgattttt
     2341 ttatacaata atgagtaaag gggctttatg tattttgcag gagttaacat tacaattttg
     2401 ttaaaaattt tctacgttac ataaagtaac aaaatttgac cctgagtgtt tgttatagtg
     2461 taaataatca aaaaacttaa aatttgtcga gtgaaaattg tgataagtaa ttcatgtaaa
     2521 aaacttaaag gggtgtacac atgcataaag aatatgaaat tgaagaatac acggcgattg
     2581 aggaacaaat acattattat tgtaaatgtt tattagtaag tcatcctgat caaataataa
     2641 aatatttaga aaaaaggtta gaaaaatatg cagaaacatt acaatatgcc catttatatc
     2701 ctgacacagt tattttaccg ttacagcaat tagttattga atattcttta gacgttgcta
     2761 gaattcggaa gtatatgaat ttaaaaacgt aaagtgaaat ttatagttta aatgaaacag
     2821 agtcgacttt aggaaatgaa attctaatgt cgactctgtt tcattgttta atatcgttga
     2881 ttgaacatac atactaatca atgaagtttg acatataatt aagcaagggt aaaataaaag
     2941 tgagtactca ctcattttat tggaaaagga ggatgaaacg tgcaacaacc ttcaattatt
     3001 ttacggactg tatcaaaaag ttttgggaaa aaagaagtgt tacacaatct ttcattgcaa
     3061 gttgaaaaag cagagatttt tggttttgtt ggaccttctg gatcggggaa aacaacgctc
     3121 attaaaatga ttgcaggtat taatgaggca acgaaaggtg aagtgcttgt taataatact
     3181 aatatgccta atttaaatga aatgaaacga attggttata tggcccaggc ggatgcatta
     3241 tatgaagaat tgtcagcata tgaaaatgca gattttatag caacgatgta tggattaaag
     3301 ggaaaaagta aaaagacaag aattgcagag gtttttgaac ttgtacaatt gtcacagtat
     3361 atgaaaaagc aagtacaaca attttcaggt ggaatgaaaa aacgcttatc attagcaata
     3421 gcactcctcc atgaaccaga aatattaatt ttagatgagc ctacagtggg gatagatccg
     3481 cttcttagga aaacgatttg ggaaaaattt tatgatctta aaaagaaagg cacaacgatt
     3541 attgtaacga cgcacattat ggatgaagct gaattttgtg agcgtctagg attaattaga
     3601 gaagggaaac tagttgcggt tggaacaact gaagaattga aaaaacgcgt gtcatctgga
     3661 cggattgaag atgtcttttt gctggaagag gtggtgccat catgagagtt actggtgtaa
     3721 ttatacgtat tattcgtcaa ttttttcgag ataagcgttc gttagcaatg atgtttggag
     3781 caccgatgtt attactttgg cttttgtcac tagtgtttac acagaaagac tatataccgc
     3841 aaattgctgt tgttgatatg cctgctcaaa tagtaaaaat gatgaaaaat caagaagcgt
     3901 caatttatga atacagtaag gaaaaggcga tttctgagtt ggaaaaacaa aaggtagatg
     3961 cagtatttcg tatagagaat ggaaaaatga aacttctgtt ggaaggtagt gattcgtcaa
     4021 aaaatcgtgc tgtacttcaa gtattgcaaa aaagcacaga gaagaatgat gtatcgatta
     4081 tgaaacctga agtaaattat ttacatggct ctaaagactt tacgatgttt gatgggcttg
     4141 gtcctgtatt aattggtttc tttacatttt tctttgtatt tatattatca ggtgtatctt
     4201 tcgtaagaga acgtttaagt ggtacgctag aaaggttatt atccacccca gtaagaagat
     4261 gggaaatagt cgcaggttat attattggtt ttggaatctt tgcctttata caatccatta
     4321 ttatcgtaag cttttccgtt tatattttag atttatacgt agctggctcc atatggctaa
     4381 cgctacttat tacatgtatg ctctctttaa ctgcactaac attaggtacg tttttatcgg
     4441 catacgcaaa taatgaattt caaatgattc aatttatacc gcttgttatt gtgccacaaa
     4501 tcttcttttc tggattgttt ccattggaat ctatgaacaa gtggctacaa atgttaggga
     4561 aagtatttcc actcacatac ggcgctgacg caatgagaca agtgatgatt cggaatcaag
     4621 ggtttacaga gattgcatta gatcttactg tattattact tttttcaata ttatttgcag
     4681 taggaaatgt atttgcttta aagaaacatc gcaaaatata ataatgacaa aaaggagctt
     4741 tataaatgca gaaggattgg ctggaggaat taatagctgc aactaatacg gataaaagaa
     4801 atgaacgtca aatgcgaata ttagaggcgg ctgttgatat gtttggagaa aaaggatacg
     4861 cttcaacttc aacaagtgaa attgcaaaac gggctggtgt agcggaagga acaatcttcc
     4921 gctactataa gacgaaaaaa gatttattac tagcggtcgt aatgccaact ttaactaagt
     4981 tcgctgcacc atttttcgta caaacctttg caaaagaaat atttaaatcg gagtatgaat
     5041 catacgaagg acttttaagg gttgtaattc ataataggtt taaatttgct caaaaacact
     5101 ttcctatgat aaaaatatta attcaagagg tgccattcca accagaactg aaaaatgaaa
     5161 tacagcaatt agtagaaaca gaactgtttt cacatttcaa aaagttgatt gtgaaatttc
     5221 aagaagaagg ggaaattatt gagataccac catcttccgt actacgtctt actttatcag
     5281 ctgtattagg tttattatta acacgatttt tattattgcc tgaagaaaaa tggaatgatg
     5341 aagcggaaat tgaaaatacg attcaattta tattgtatgg attaactcca cgaatttaat
     5401 cgttgaagtg tgaattacat acattacttt taagtaaaaa taaatcgcct ttaaaaaggc
     5461 gatttatttt cattatatat ttttgataaa taagtgcttg tttactaaaa acattctaaa
     5521 tcagcgtgtt tctttgtctc ttcttctaag acctaataat cctgctagtc ctaataaacc
     5581 aagccaagcc caattattat ttttatcacg attatcattt aaatcatttg ttgtatttac
     5641 atttcgagtt cttacatcat tattaactct gtctaagtta ttgtcattta ctcgagttga
     5701 aatatcagtg ttattaactc tattcatatt atttccatcg tattcagctt gcgtagatgt
     5761 acctaaaaac ataatagata gtgttaaaac actcaaaata gatgataatt tctttttcat
     5821 aacaatccct cctttcttaa tcattaattt ctccgaagca tgtgtgtatt attcatttca
     5881 caatatctaa accctcatta atagggcgca catttataga aaatagagtt gaatgattgt
     5941 taatgtatca ttggatttat atttctcata aaaataactg aatcaaactt tgcttaaaat
     6001 gttaatctta gtacaattta tattatacgg actagtaata aggaggtaat aagatgcgac
     6061 aatttgcaaa acctacaatc gtcgtaagta aatgtttaga atttgatgct tgtcgttata
     6121 atggagagat gattccagat gtaacaatac gaaatttgca gccatttgtt acatttatac
     6181 ctgtttgtcc agaagtcgag attggattgg ggactcctcg tgaaacgata cgaattgtag
     6241 aagaaaatgg tgagaataga cttgtgcaac cgtcgacacg agaagatgta actgaaaaaa
     6301 tggagcagtt ttcaaatgac tttttacaaa cgataccgga tgtggatggt tttattttaa
     6361 agaatcgttc accaagttgt ggtacgcgtg atgtgaaaat ttattctggt tttgaaaaag
     6421 cgccagcaaa gggaaaagga gctggcttat ttggcggagc agtagtaaaa aaattttcgc
     6481 atcttcctat tgaagaggaa ggtagattgt cgaattttat tattagagag catttcttta
     6541 caaggctatt tacaatcgca tattacaaaa tgattaaaca caataaaaat atgaaagaac
     6601 ttgtatcgtt tcagtcggat aataaatatt tatttatggc atataatcag gtgaaacaaa
     6661 aggaattagg tcgtataatt gcaaatcaaa aaaatgaaaa gattgaagtg gtatttgaaa
     6721 actatgagaa gactttatat gaattattta tgcgtgcgcc ccgttataca tcgaatgtaa
     6781 atgtatgcga gcacattttt ggatatttta aaacaaagtt aaaaaaacaa gaaaaagatc
     6841 attttataga actgttacaa aagtatgcag aaaagaaaat accacttagt agtttactta
     6901 caattttaaa atcatgggct attcgatttg atgaaaagta tttattaaga caaacatatt
     6961 tcgaaccata tcctgaagca ttagtagaaa tttctgattc cggaaaaggt agagattatt
     7021 aaacaataaa ttacataatt cgacacaaaa cctcctatgt tgttgtagaa caatgtagga
     7081 atttttttgt gcattagtac agaatctgtt ttaaaattaa gttatgacag aattatagca
     7141 attgtctaac taatattctt gtcttttaag ttgttatgtt tgtagtagaa actcgcacgc
     7201 tgtcgaaact caatattcga taaggggtgt gtagcggaat ggaatttact ctaactcgcg
     7261 aaaaacaaat gattaaagaa atggtacgtg actttgctga aaaggaaatc gcaccgaaag
     7321 ctgtatatta tgacaaaact gcagagtttc catatgaaac atttcaaaaa atgggcgaac
     7381 taggattact aggcatccca ttcccagaag agtatggagg ttcaggtggc gatacggtat
     7441 cgtatgcgtt agcagttgaa gaaattggtc gcgcttgtgg tggcactggt ttaagctatg
     7501 ctgcaacaat ttcattaggt gcttctccaa tttattattt cggtacagaa gaacaaaaac
     7561 aaaagtattt agttccaatg gcgtcaggta aaacattagg tgccttcgga ttaacggagc
     7621 cgaatgctgg atctgatgca ggtggtactc aaacgaaagc ggtattagat ggcgatgagt
     7681 atgtaatcag tggtgagaag tgttggatta caaacgcaga gtatgcaaat acaattattg
     7741 taaccgctgt caatggcgtt gaagagaatg gtagaaaacg tatttctgca tttatcgtgc
     7801 ctactactag tgaaggatta acgatttcaa gtccatacga taagatgggt gttcgtgctt
     7861 ctaatacttg tgaaatcgta cttgatggtg tgcgtgtacc gaaagaaaat attcttggtg
     7921 atgtaaataa aggttttaaa caatttttat atacacttga tggagggcgt atttcaatcg
     7981 cagcattggc agttggtatt gcgcaatcag cctttgaacg tgcattgcaa tatgcgaaag
     8041 aacgtcaaca atttggaaag tcaatctcta atttccaagc gattcaattt aaattagctg
     8101 atatggcgac tgaagtagag ctagcacgca atttagtaca taaagcagct tggttaaaag
     8161 ataacgataa acctttcggc aaagaagcgg caatggcaaa actatttgca tcggaagcag
     8221 caagccgtat tgcgaatcaa gcagtacaga ttcatggtgg atatggttat atgcgtgaat
     8281 atgaagttga acgacatatt cgtgatgcga aactattaga aattggtgaa ggaacttctg
     8341 aaattcaacg tctcgtaatt gctagacatt taggatgtag ataaaaggga ggaatcacta
     8401 tgtttcaaaa aatattaatt gcgaatcgcg gggaaattgc tgttcgtatt atgaaaactt
     8461 gtcaaaaact tggcatacgc actgttgcta tttattctga agcagatgaa aatgcccttc
     8521 atgtgaagat ggcaaatgaa gcttacttag taggtggacc gcgtgttcaa gaaagttatt
     8581 taaaccttga aaaaattatt gaaatagcta agaagacaaa tgcagaagcg attcatccag
     8641 gttatggttt attatcagag aatccgtctt ttccggttcg ttgcaaagaa gaaggaatcg
     8701 tatttatcgg tccttcagaa gaaatcatta cgaagatggg aagtaaaatc gaatcacgta
     8761 tcgcaatgca agcagcagat gtcccagtag tcccaggtat tactacaaat attgaaactg
     8821 ctgaagaagc aattgaaatt gcaaaacaaa ttggttatcc attaatgctt aaggcatccg
     8881 caggcggcgg aggcattggt atgcagttga tggaaactga gcaaacgctc accaaagcgt
     8941 ttgaaagtaa taaaacaaga gcgcaaaact tttttggtaa cggagaaatg tatttagagc
     9001 gatatatagc agacgcgcat catattgaaa ttcagctttt agcagataca catggtaaca
     9061 cagtgtattt atgggagcgt gaatgttcgg tgcagcgccg aaatcaaaaa gtaatcgaag
     9121 aagcaccttc accattttta gatgaaggta cacgaaaggc aatgggagaa gttgctgtac
     9181 aagctgccaa agcacttggc tatacaaatg caggtacagt tgagtttctt gtagatgatc
     9241 agaagaactt ctatttctta gagatgaata cgagattaca agtagagcat ccagtgacag
     9301 aagaaattac gggattagac cttgtagaac agcaacttct tatcgcaagt ggagagaaac
     9361 tatcatttac tcaggatgat gtaaaacgta gtggtcatgc cattgaagct cgtatttatg
     9421 cagaagatcc gaaaacattc ttcccatcac ctgggaaaat tacaaattta acattaccgt
     9481 caaatgtacg gatcgatcac ttcttagaaa atcatgtaac gattacacct ttctatgatc
     9541 caatgattgc gaaagtcatt gcacatggcg agactcgtga agaagcaatt tcgaaattac
     9601 atgatgctct agaagaatta aaagtagaag gtattaaaac gaacacgcca atgctactgc
     9661 aagttttgga agacgaagtg ttcaaagagg gtatttatac aacgggtttt gtaacgaaac
     9721 aactcgttaa aaaataagat ttaacaatat taagggggaa aaaatgatga cgaaagtata
     9781 cgcatcgatg gcaggaaacg tttggaagat tgttgtagga gtaggagata cagtagagga
     9841 agagcaggat gtcgtcattt tggaatctat gaaaatggaa attccaatca tttcagaaga
     9901 agccggcaca gttatgaaaa ttaatgtgca agaaggcgat tttgtaaatg aaggagatgt
     9961 attattagaa attgaatagg gagatatagg gggaagcgaa ttgaaactac ctaattttgc
    10021 tgtcattaaa gaagtcgggc cacgtgatgg cttacaaaat gaaaaaaaga ttgttggcac
    10081 aaaagataaa gtaaaatgga ttcaactact tacagaagca ggattgtcgt atgttgaagt
    10141 ttcctcattc gttcacccaa aatgggtccc tgcattagca gatgcaaatg atgtattttc
    10201 tgagctgaaa agggatccaa atgttacata tgctgcgctt gttccgaatc aaaatggttt
    10261 ggaacgagct tttttgcaaa atgtagatga ggtgaatgtt tttttatcag caagtgaatc
    10321 tcataataaa agtaatatta ataaatcgat taaagaagca ttagttgtaa ttgaagatat
    10381 aacaaaacag gcattattcg aagggaaaaa ggtaagaggc tatgtttcta ctgtatttgg
    10441 atgtccttat gaaggggata taagtgctac agcagttgac gaattatgta atcaactatt
    10501 ttcatacggc atttatgaag tttctcttgg ggatacaatc ggtgtagcga atccattaca
    10561 agtagaacaa gtattagaac acctattaaa gaagtatgat gcttcgcagt ttgcaatgca
    10621 ttttcataat acgtatggaa tggctctagc gaatgtagtt aaatcattag aatacggtat
    10681 tacaacgttt gatagttctt gtggtggact tgggggctgc ccttatgcac caggagcatc
    10741 aggtaatgtt gctactgatg acctagtaca tatgctccat aaattaggag tccaaacgaa
    10801 tatagacgaa gaaaagttat tgagagctag tcaatttatt caaagtaagt taaatatcca
    10861 attaccgagt catgtgtata gagcgcttca acataaaacg ataagtaggt gagtagatgc
    10921 tacaattaca aaacatttcc gttgattacg taacacctca cgtagtaaag atttcgttaa
    10981 atcgtgcgag acaagcaaac tcattatctt tggcattatt agatgaatta caaactatat
    11041 taactcaaat aagtgaagat tcaagcgcac gtgtagttat tttgactggt gctggtgaaa
    11101 aagcattttg tgctggtgca gatttaaaag agcgtgccga tatgaatgaa gaacaagttc
    11161 gtcatgctgt tagtatgatt cgcactacta tggagatggt tgaacaatta ccacagccag
    11221 ttattgctgc tataaatgga atcgcacttg gtggtggtac ggaattaagt ttagcttgtg
    11281 attttagaat tgctgctgaa tctgcaagtc ttggtcttac tgaaacgaca cttgcaatta
    11341 taccaggagc aggtggtaca cagcgcttac caagattaat tggagttggt agagcgaaag
    11401 aattaattta tacaggtaga cgtatttcag cgcaagaagc aaaagaatat ggtttagtag
    11461 aatttgttgt accagctaat ttacttgaag agaaagcgat tgaaatagca gagaaaattg
    11521 ctagtaatgg acctattgct gttcgattag caaaagaggc aatttcaaat ggtattcaag
    11581 ttgatttaca taccggatta caaatggaaa aacaagcgta tgaaggtgta atccatacga
    11641 aagatcgaat agaaggatta caggcattca aagaaaaacg taaaccgatg tataaggggg
    11701 agtaaatatg ttagaccaaa aacaacaatc taattcattt gaagaacgtg ttgaaacgat
    11761 taaacaaggc ggggcaccga aatatcatga acaaaataaa gcaaaaggaa aattatttgt
    11821 tcgagatcgt ttagcgcttc tatttgataa tggcgaatat gtagaagatg cattatttgc
    11881 taactgtgaa caaacaggct tacctgcgga cggcgttgta actgcaacgg gtaaaataca
    11941 tggtcgtact gcgtgtgtaa tggctaatga ttctactgta aaagctggat catggggatc
    12001 acgtacagtt gaaaagattt tacgtattca agaaacagct gaaaaattac gtgttccgtt
    12061 attttattta gtcgactctg ctggagcgcg tattacagat caagtagaaa tgttcccagg
    12121 gcgccgcggt gcaggaagaa tcttctataa tcaagtgaaa ttatcaggta aagttcctca
    12181 agtatgttta ttatttggac cttctgctgc tggtggtgca tatattccag ccttttgtga
    12241 cgttgtaatg atggtagaag gaaatgcatc tatgtattta ggatctcctc gtatggctga
    12301 gatggttatc ggtgagaagg taactttaga agagatgggc ggagctcgta tgcattgctc
    12361 tgtatcagga tgcggagatg ttttatgtaa gacagaagaa gatgcgatta cacaagcaag
    12421 acaatacatt tcatattttc caaacaacta cttagaaaag actccattgg ttacacctca
    12481 agaaccgaaa caattcgata aaacgttaga acaaatcatt ccagaaaatc aaaatgctcc
    12541 tttcaatatg aaagatctca ttaatagagt tattgatgaa ggttcattct atgaagtaaa
    12601 aaaattattt gctcaagagc taattacagg cttagcacgt attgatggta agccagttgg
    12661 tattattgca aatcagccgc gtatgaaggg cggtgtatta tttcacgatt cagctgataa
    12721 agctgctaag tttattaatt tatgcgatgc atatcatatt ccattattat tccttgcgga
    12781 tgtaccagga tttatgattg gtacaaaagt agagcgtgct ggtattattc gccacggtgc
    12841 aaaaatgatt tctgcaatga gtgaagcaac tgtaccgaag atttctatcg ttgttcgtaa
    12901 agcatatggc gctggtttat atgcgatggc aggtccagca tttgaaccag attgctgcct
    12961 ggcattaccg acagcctcta ttgcggtaat gggtccagaa gctgcggtta atgctgtata
    13021 tgcaaataaa attgcagctt taccagaaga agagcgcgct agcttcattg ctgaaaaacg
    13081 tgaagagtat aagaaagata ttgatatata ccacttagca tcagagatgg tgattgatgg
    13141 tattgttcat ccaaacaatt tacgtgaaga gttaaaagga cgtttcgaaa tgtatatgag
    13201 taaatatcaa gtattcacgg atcgtaaaca tcctgtatat ccagtttaaa agccctattt
    13261 agggctttct tgctcaaaaa gttaaggagg ggaaaacatt gaaacaagca gtttggtttc
    13321 caacagaaga gtataaggaa aaaacacgtt tatatggttg gatgaaatca ttgggctatg
    13381 aagactatga aactttttat aataaatcta ttgaggaaac agcttggttt tggggagagg
    13441 cagaaaaagc agtaggctat caatggatga aaccttatac agaagtgtta gatttagaaa
    13501 atggtacacc gtttgcacag tggtataatg gcggaacatg taacgttgta gaatcagctt
    13561 tatcccgctg gcttgcggat gaagaaacga gaatacagcc agcacttcag tacgaagggg
    13621 aaaatggaac ttcaaaatca tttacatatg aagagcttga taactgggta agccgtgttg
    13681 caaatggttt gaaacacgcg ggtattgaga aaggtgaccg tgtaacaatt tatatgccga
    13741 tgattccaga aacagttgtt gcgatgctag ctgtaatgaa aatcggtgca attatttcac
    13801 caatattctc aggctttgcg tctgatgcag tcatgacacg tgtgcaagcg gcaggttcaa
    13861 aaatgattat taccgcagat ggattttcac gccgaggaaa aattgtttct ttaaaagatg
    13921 aagtagataa agcttgtgaa cattgcccaa ctgttgaaaa agtggtaatc gttcgtcatg
    13981 caggaaatga ttttacacca cataactatg acttttcgtg gagtacgcta gaaaaagaaa
    14041 aaccattcat acatgccgaa gaaatgcaaa gtgatgatcc attaatgctc atttatacat
    14101 caggaacgac tggtaagccg aaaggaacag tacacacgca tgcaggattt cctttgaaag
    14161 cagcttttga tgcaggattt ggaatgaata ttaaacaagg tgatcgtgta ttatgggtaa
    14221 ctgatatggg ctggatgatg gggccatttc tattattcgg ttcactcatt aatggagcaa
    14281 cgatggttat gtacgaaggt gttccagact tcccagaagc agaccggtta tgggagacag
    14341 ttgataaata tgaaattact catctaggta tttcaccaac gttaatacga gcattaatgg
    14401 caaaaggtga taagtatgtc aataaacatt ctttaaagag tttggaagta tttgcatcaa
    14461 caggagaacc ttggaatcct gatccatgga tgtggctgtt tgaaacagtt ggaaaaggaa
    14521 atgtaccaat ctgtaactac tcaggtggaa ctgaaatctc tggtgggatt ttcggtaatg
    14581 ttcttattaa gccaatagca ccgattagtt ttaatgcatc tttaccagga atggcagctg
    14641 tcgtactgga tgatcaaggt aaaccaattc gagatgaagt cggagaatta tgcttagaga
    14701 aaccttgggt aggtatgacg aaaagcttct gggaagatga tgaacgttac gtaaacacat
    14761 attggtcgcg ttttgaaaat aaatgggtcc acggtgactg ggtcatttac gatggtgaac
    14821 aatatatcat cacagggcgt tcagacgata cgttaaatat tgcaggtaaa cgtattggac
    14881 ctgctgaata tgaatctatt cttgtgaaac ataacgatgt aatcgaagct gctgcaattg
    14941 gtgtacctga taaagtaaaa ggtgaagttt gtcattgttt cgtagtatta agagaccatg
    15001 taacattcac aggagaatta aagaaagaat taatgagttt agtaaactct catattggaa
    15061 aagcgttgtg tcctaaagac atccacgttg tagaagattt gccgaaaaca cgtaattcta
    15121 aagtgatgcg ccgtgttatt aaagcagctt atttaggaaa agaattaggt gatttgtctt
    15181 cacttgtaaa tcctgaagta gttccgttta ttcaggggtt acagtctagt aaattataaa
    15241 cataagaaag gatnnnnnnn nnnnnnatcc tttcttatgt ttataaaaag agaaaaagtg
    15301 aagttgatga agaaaaattc tactattagt gttaagtatg ttttatagtt ttaatcaaaa
    15361 tacgatatta tggaatgtct actcaatgga gaaatactaa tttacaacaa ggtgataaca
    15421 aagcgtgcct gctttatatg tctgttaaaa cttttacgtg ttaatatata aaaagctgac
    15481 tatactcagt cagcttttta tatattacat tctagtattt atttcactat ttgccgggca
    15541 gtaatgcccc cacctaaaaa ttcagcgaaa gtaaggaagt aggtgtggga ttaactttcc
    15601 ggaaaagccc gattggttcc aaaagccata ttctttcctt tacgttgata ttaaaaagat
    15661 taccaatttt ttcttttaca atggcaacaa ataaagaaac atttacaacg acacttattt
    15721 cgtttagaac cccaatcatc atcacgatga cacttttctt tagatttcca ccaatcatca
    15781 ttacaatgct ttttctgaga actccaatca tcatcacaat gatgcttttc tttagatttc
    15841 caccaatcat cacaacaatg ctttttctga gaactccagc aatcattttt ccaagacatt
    15901 catttctacc tcctttcaat agtgttcata ttattctatg ttttaataaa aaaatggctt
    15961 gtttattaac ctactatttt atctttatat gatagagtgt tttctactcg atatagagtt
    16021 catacaaacc atgctaattt ttaagagata gtggagagaa ctactactag ttatggtgtt
    16081 ttccaataaa catttgttga agaaagcgtt ctgattacaa ataatatctt attttcgagt
    16141 acgctttttt aaatgtatat ttcacaataa caaaggaaaa atccacaaat aaagtctatg
    16201 tatatgtgag ttaatggaaa aatctagtgt gtttttaagg agcgtcttat ttaaaagaaa
    16261 aaagatttgt tttagaaagt ggtgtctaaa cattaaatgg agtaggacta aattcacggc
    16321 cgctcattaa acaagctttt aattaggaga agtctgtttt tataatgaat aatgaaaaga
    16381 aagtatagta caattgtttg tttttttctt tttatgtgtt tgtctcgtac ccttttaagc
    16441 tagtggacat actttactaa tagaaaggat tagggggtga ggtattgggt tctcgattta
    16501 ataattgtaa aaagaagtgt acatgtaaac aagatgattg ttgggaagta ttcgaagagt
    16561 gtaaaaaaga acagcatgag aaatgtgata attcttgtgt acaaggaatt agagatgaac
    16621 ttaagaaatt aattaatcga acagttcaaa ttaatacaga gggacgtact tatgtaggta
    16681 ctgtttcgtc tgtaagttgt gatctagtta ggcttgcggc tattcctgga tcggttggag
    16741 taattatttc catttgtaaa attgaagcaa ttttcccacc tgttacaacg gttactgctg
    16801 actttgattt taatggtatt gatgtagcaa acaaagcata attatgctgc ttttttgtaa
    16861 agccattcac atgaatggct ttattttaat ttcatataaa aggagaatat attctttata
    16921 tagaaataag tttgaggtta taaagcatga tgtatgaaag gagcaaggaa gtgattaaac
    16981 tagaaagctt taagaaatct gattttaaac aattaataaa ttggattaac tccgaagaat
    17041 ttctaataca atggtcagga aatgcattca cattcccttt agacgaacag caattagaga
    17101 agtatataga aagtgcaaat acactcgctt tcaaagtggt agatgaagtg acttcagacg
    17161 ttattggtca tatttcgctt gggcaaatag ataatattaa taagtccgct agaattggaa
    17221 aagtattagt tggtaatacg aagatgagag gacgttctat aggaaaacat atgatgaaag
    17281 cagtacttca tattgctttt gacgaattaa aactacatag ggtaactctt ggtgtgtacg
    17341 attttaatac atcggccatt ttctgttacg aaaaaatagg gtttgtaaaa gaaggcttat
    17401 taagagagtc aaaaagagta ggagaaacgt attggaattt atgggaaatg agtatgttag
    17461 aatatgaatg gaagaagtag caacaatagt tatttataat tatattatgt taacaaaagg
    17521 ggcttggtgg gtatagtgga taataaaaca aaaataattt caattgcagc tgtttcaggg
    17581 ggagagctag tatattaaaa ctgacaaaga aaccattttt gaaaaaggcc cacctgcatt
    17641 gtttctgagg aataagaggg tgagccctaa ttaaacgaaa ctgaatgaat ctgtaaaaat
    17701 tgtaactaaa gtatgcatca acaaggtatt gaaagggatg aatagtaagc tttacagatt
    17761 attccatatg taacaaaact ggttagcttc tgatttaagc gctactaaat gattattatt
    17821 aatagagtta ttcgtataca ttctgttctt ttggatgtta agtaccgtat aattcacatc
    17881 gtttcgttca tttgaaaatg ttgattcatt taatagtgta agtgtcgagt taatgttgta
    17941 tttatcaatt cgctcttttt ttcctttgaa aaacagtttg ataagatgtg gctcattatt
    18001 aatgaataag ccaagttcag gtgatgaacg gacgattaaa tcatctgatt tccaatgtga
    18061 tttacctgga tcaaaccagg agatgtcttt atttttaatg aattttttgt attgctttat
    18121 aacatcaatg tagttttgtt tttttttctg atcaaccgtt tgtactaatg tttcgaaaca
    18181 ttcaaaaggt agtttgtttt gatgaaattt aataacagtt tctcgtaatt gtttccagta
    18241 atcaaaagct ggttgatatt caggttggga ttttagattt tttataaagt ttgttttagc
    18301 tgtactacct ttcagtgtga agtctaaaaa ttgtgtaagc cctactttaa tttctgtcat
    18361 attacatcac ccttccaaac attattcatt taataataga cgaaataccc tacattttta
    18421 aagaaatgag ctagatgcta gaaaacctaa tgtccatgca caatagatac gggaaagcca
    18481 atccgtaagt ataaatgatg gaccatccaa ttgaagataa attagataat ggttaccagg
    18541 tgataggtta ttaatataat cggatagtga ggcgagttta aaagataaca atatagatta
    18601 tttagcttgg atttgagaaa aaagtgcatg ggaataaaga gggatatagg gaaatgggct
    18661 ctcatcaaaa aatataagtt ggtatcagta taccgtagag aatgagtgta tagaacatac
    18721 aagtaaaagt attggctagc acacttaaaa taagccgtat aaaaagttaa tcatcgtgtg
    18781 ctttgattat ataatgtcgg cgaaataaat agtgtgaagg acagcgatct taacaagtgt
    18841 ttcatgtaac gttcatgtac tttaattttt tataattaat caaatttgaa ttttgtttgt
    18901 tgttaagaaa aggtgagaag aaaataaaaa aagagggcta atgccctctt tttttattaa
    18961 tttggtaatt aatcacagat tggtatccca agcactctta gagctaatgc tacttgaagg
    19021 gaaatctcta atctagcaat ttcaatacca gctactgaaa gaactaaaaa aggttgtccg
    19081 tttacaaata caacgcaact atccatagtt aagcctcctt tctagtaatc tactatagta
    19141 tatgaataga actttaatat gtaatagtta aattgttgga tttaatagaa ttaatagatt
    19201 aacccattta aactaaacaa acgaacacaa cgaacggaaa cagagatgga tgtatgcctc
    19261 gaaaaacata ggttttaaga catgggatat gaaattcatc atattggtca gctgtctata
    19321 tgggcgaggc agttaaactt gcaaccagtt tcagcaaatt taattggaag aggatgatag
    19381 aattaaaaac cgacttgcat ctcaaacgca agtcggtttt tatatataag aagatttctt
    19441 aattgaaatc ctcggatttt ttctgacgta tatgtaaaaa cattaaggtg gtaatgatta
    19501 aaaaaatcat tatagtttgt ataattaaat ttttaaactg aagcaatatt gtccacgatg
    19561 taagggtgtc tttaaaagct tggagtgcag agtacgagga aggatcaaaa ccatactgta
    19621 gcaacttttt tgtttcaata aatgaaatgt tttcttcatc tgcatctaat attactgaaa
    19681 ttagtctagt atcttcaagt tttgctgtac tgacaaaact ataattacca ttagttgaaa
    19741 aactagtttg taagccatca acaccttgaa gtttaatgtt ttcattaagg gaatatatca
    19801 ttttattcgt attgaaaacc tgggaatctt tgaaggaaaa ttggtaagag gttagtttcg
    19861 taatattcaa tacatctgga aaatctttta ttaatcgtgc tgctaattta gctgcgtcta
    19921 ttgctgttgt agttgattgt ttatttgtat cattattaat tccagtagag tttagaaatg
    19981 gagatggttg taataacttt agttcttttg cttttttatt cattaatact gtaaagttat
    20041 cttcatttcc agcaatgtgt tctgcaagag cgagtgcaga acgattattc cctgccagta
    20101 gcaatgcatg aagtaaatca cgaaccgttg ttttatcatt cgatgttact tgtatagggc
    20161 ttgtttctac tcggaatact tcgttactta tttgtacgaa gtcatctaac tgtatttttc
    20221 tatcatttag ttgctccaat acgatatatt ctgtcattaa tttagataaa gcagctgatt
    20281 gtactggagt ttcttcattt tttttataaa caatttcacc tgaattagca tttattaaga
    20341 tagctgattt agcttgaata atcggaccat ttacataaag gtaaaaatat aaaacgataa
    20401 gtgcagtaat gaaaaaagat aataataaaa tagcgaattt ttttaagaat tgcataagcg
    20461 atcctcctat tatgacatca ataatagtat tgtaaaaaag aatgcttaat taggaagaaa
    20521 gaaaaggtaa agaatttcta aagaattata aaggattatt aattttttgt aattaatgga
    20581 aaaagttcaa tttcttatat gataagaaat tgaacttttt atttgtgata ttaacctttg
    20641 taggggagta gttttacagt gaaagttgtt ttttcgtcat cactatatac ttcaattgtt
    20701 cctttatgca attcgactat actttttgca attgctaatc caagtccaga tccaccagtg
    20761 tttgtagagc gcgatttttc aacgcgataa aaacgttcaa aaatatgagg taaatccgta
    20821 ctaggaatag gttgtccgta atttgttata tcaattgtaa tcatattatt gctttcataa
    20881 gcagtaaggt caatatagcg accttcgctt ccataagcga tagcgtttat aataagattt
    20941 tcaaacacac gcactaattt gtcaccatca gctaatacca tgagcttttg agatgggaaa
    21001 gaaggtctac attctatatt agcttcttga acctgtattc ggaattgaac agttaattgt
    21061 ccaagtaact ctacaatatc aatggggaca gaatacaagc ttaactcttt attttgaaca
    21121 cgtgtatatt cgaacaagtc attcattaat gcattaagac gagttacttt atcataaatg
    21181 acttgaatat agtatcgcaa ttccacttca tctctataat tatcatgatg aattaaattt
    21241 acgtatccaa ctatagaagt aaggggagta cgtaaatcat gtgatacatt tgtaataagt
    21301 tcactctttg cttgttccgc ttgtctttct tcatcaattg agacttttaa ttgttcaaca
    21361 atttcattga ccccgattgc taactcttcc aaataattat gatttacaac agaaacttta
    21421 tgattgaagt ttccatttgc aatgtaacga atttcttcta tcattttttt tatacaagtt
    21481 tcatagtaaa gttttctctc gtgacgataa aaaatgtaaa gataggatga aaaaatagaa
    21541 aataaaaaca aataagaaac aatcatcatc cataaagatt ctttaacccc tttatacttt
    21601 tcataaccaa aaattcgaat gaattcttta ccgagctcgg ttagagtaag tgaactttca
    21661 attacactcg taacgaggcg ataaataatt aattcagtaa taggagtgag tgtgatagct
    21721 agtaagagcc aaaaaataag tttccattta gggatatctt ttaatatatc aaatgcttca
    21781 tttctcaatt ttatagccaa ctccccaaac agtgtgaata aatttttctc cattcattac
    21841 cgtttcaagt ttatcccgta agttgctaat atggaccatt accgtcttat ttgaaccata
    21901 accatcttca ttccaaacgc gttcgaaaat ttcttctgaa ctaaatactc ttcctgtatt
    21961 actcgcaagt aaatataaaa tatcgaattc aatagaggtt agtttaatat actctccatt
    22021 tactttaaca gtatgattat gtttgtgtat ttcaacagag cgaatacgaa taataccatc
    22081 ttcattcttt tgcgaagtag cattttggaa agatgatctt cgtaataaag ctttcactct
    22141 agctactaat tctaatggat tgaatggttt gatcatataa tcatcggcac ctgtcataag
    22201 acctaatatt ttatccatat cttctgcttt tgcactaagc attagaattg gtacagtatt
    22261 attttcacgt acttcctgac aaacttctaa tccgtttcgt tttggcatca taatatccaa
    22321 aatcataagg tcaacttcat atgtagaaac cttctgcaat gcttcatcgc catcataagc
    22381 tttataaatg ttatagcctt catttcgcaa ataaacagca agtaattcaa caatttcttt
    22441 atcatcatca ataattaata tgtttttatt cattttgtag ttcctttcct tacaaatcat
    22501 caacattact ataatatcaa acatttatgt acttgtagca atgattctgt ataaaatttc
    22561 atgtaacgta ttaaaaagga gtaaaaagat taataacgaa tataaaataa caaagatatt
    22621 taaattctgc attatactga aagttagtta taagggggat tttctatgtt atataatgat
    22681 atatattcat ttgctccaac tggaaaaata gacaatgata ttaaagattt tctactaaaa
    22741 tataataaag agtttacata taaacattca attcgtgtgg caaatgaggc aaaaaagatt
    22801 gcagaaaagt ttcacgtaga taaagaaaaa gcagcaattg caggatattt acatgatatt
    22861 agtggcattt ttccgaacga ggagcggatt gcagttgctg aagaatttgg ggtagaaata
    22921 gaggaagcag aaagaaagtt tcctatgatt attcatcaaa aactatcgag agtaatcgca
    22981 aaagaaatat ttaaagtaga agatgaagac gtattagatg caatttgttg tcatactaca
    23041 ctgcgtaaac acccaacaaa gatggattta gttttatttg ttgcagataa aatagaatgg
    23101 gatcaaaagg ggacaccacc atatttaata gaaataaaaa aggattggaa aaatctttgg
    23161 aaaaagctgc ttttgtatat atttcatatt tgtgggaaag gaaagataca ttgaaagtta
    23221 tacatccgtg gctagaagaa gcatattggt atttaaaaag aattgtacag tagaagggac
    23281 aaggaaatgc aattaaaaga atatatgaat caaacatttc caggagttac attagtaccg
    23341 tacttatatt ctcagtgggg aaatcatttg tattttgatt ttggaaaaga taaatatcaa
    23401 attgtagaag gaaccgacga tttaaatatg gaatactttt ctcagctata tacatataat
    23461 aaattcttat ttgaagacat attttcaaaa gaagatgtag tgtttgtagt gacaaatgtt
    23521 tatagattta aaaaggaaaa cacaaaaact ccacagaaaa taaatgtata caataaatat
    23581 attaagaaaa gagatttaag atttcatata agacaagaaa cgttaccgtt tctatttgaa
    23641 gatgaagagg cagatttatc ccgctatttg ccgggcagta agacccccac ctcaaaattc
    23701 agcgaaagca aagaagatag gtggggggcg ggctgcccct aaaagcccga ttggtgaggg
    23761 ctgataatca gtgggggatg aactgattaa agtttcacat tatattgtac atatcaattt
    23821 tctttaaaat gtcttgcgga agatattaaa tatgaatcgc ttatacaagc tgctaatcat
    23881 gaggatttct ctattttgta tcctcgattt ggacggaaaa aagaaatttc ttatccagat
    23941 gtatttctca taaatgcaac gaaagatatt gtcatgttta tgtatgatga tagaggatgt
    24001 gaagtaattg cgaagaataa agaaataata cgagatttat ataagaaata taaagaatgg
    24061 attccagatt atgaacgaga aagtatagat aacttattta aatgacaata ggggaagtga
    24121 agcgtgtaat gaaacgtatt gcaattgtat ctgcatggga accagaactg acgtatttgc
    24181 atcaacatta tccgagtgaa cgtgttgaaa aaagagcagc ttgggaattt cattttcata
    24241 ctatcaatga gctggaaatt atatcagttg taactggtgt cggtaaagta agctgcgcta
    24301 gttgtgtaca attgttaatt agtgagtttc agccagatga gttgtttatg acaggaatat
    24361 gcggaagttt atcaaacaaa gtgaaaaacg gtcatattgt agtagcacta aacgcaatac
    24421 aacacgatgt tactgctgct ggctcaggag aagatgtttt taatttatat aacggtagaa
    24481 cagcacctat tgaaacaaca aaatcacttg taagaagaat aaaaaaaata cgattgtatg
    24541 atccgataca tttcggtaca tttttatctg gagatcaacg tattcgtagt tcagaaatga
    24601 gatatttact tcatactgta tacggagcat tggcagttga tcaagaagta gcagctttcg
    24661 cctatgtgtg tcaaataaat aaaaaaccat ttttatgttt aaaagctgct tcagatcaag
    24721 caaatgataa aacgaaagaa gaacaaaaaa tctttaaaat gctagcatgc gaaagagcat
    24781 gtgagcattt aattgctttt ttacgtgttt atgagattaa tgtagtaaat aatagatagt
    24841 ttgttataaa acaaattaat agtaagttat atgtagggaa atgtccgttc attccaaatt
    24901 aagagctgaa atttataata gatggaatat attatatggg tacatgttga ggttaataca
    24961 agcaattgga gggcaatttt atatgattca atataaaagg tgtagtgaag taaatattga
    25021 tttagtatat gaagctttta aagatggatt ttccgattat attattaaga tggaagtttc
    25081 aaaagagggt tttatacaac gtttttttgg accagaaggt aatttgctag aacattcttt
    25141 tcttgcttta gacggtgaca aatcagttgg cgtaatatta ggtggtataa aggattatga
    25201 aagtataaag actatgcgct gtggaacatt agcggttca
//
