Select genomic region:
Overview
3.1
4.1
5.1
12.1
19.1
23.1
24.1
24.2
36.1
39.1
56.1
58.1
60.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_NUIO01000023.1 (Bacillus thuringiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | NRPS | 180,283 | 227,299 |

NZ_NUIO01000010.1 (Bacillus thuringiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | NRPS-like | 92,084 | 135,665 |

NZ_NUIO01000011.1 (Bacillus thuringiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 5.1 | RiPP-like | 59,088 | 69,366 |

NZ_NUIO01000017.1 (Bacillus thuringiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | NRPS | 7,209 | 73,117 |

NZ_NUIO01000077.1 (Bacillus thuringiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 19.1 | NRP-metallophore,NRPS | 203,916 | 255,664 | High | bacillibactin | NRPS:Type I

NZ_NUIO01000080.1 (Bacillus thuringiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 23.1 | terpene | 133,513 | 155,366 | Low | molybdenum cofactor | other:other

NZ_NUIO01000070.1 (Bacillus thuringiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 24.1 | betalactone | 14,721 | 39,959 | Low | fengycin | NRPS:Type I
Region 24.2 | RiPP-like | 91,187 | 101,516 |

NZ_NUIO01000031.1 (Bacillus thuringiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 36.1 | lanthipeptide-class-ii | 1 | 16,545 | Medium | staphylococcin C55 α/staphylococcin C55 β | ribosomal:RiPP:Lanthipeptide

NZ_NUIO01000034.1 (Bacillus thuringiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 39.1 | RRE-containing | 1 | 14,256 |

NZ_NUIO01000008.1 (Bacillus thuringiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 56.1 | NI-siderophore | 83,187 | 114,894 | High | petrobactin | other:other

NZ_NUIO01000009.1 (Bacillus thuringiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 58.1 | terpene-precursor | 205,238 | 226,128 |  |

NZ_NUIO01000002.1 (Bacillus thuringiensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 60.1 | azole-containing-RiPP | 260,245 | 283,751 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | NRPS | 180,283 | 227,299 |
Region 4.1 | NRPS-like | 92,084 | 135,665 |
Region 5.1 | RiPP-like | 59,088 | 69,366 |
Region 12.1 | NRPS | 7,209 | 73,117 |
Region 19.1 | NRP-metallophore,NRPS | 203,916 | 255,664 | High | bacillibactin | NRPS:Type I
Region 23.1 | terpene | 133,513 | 155,366 | Low | molybdenum cofactor | other:other
Region 24.1 | betalactone | 14,721 | 39,959 | Low | fengycin | NRPS:Type I
Region 24.2 | RiPP-like | 91,187 | 101,516 |
Region 36.1 | lanthipeptide-class-ii | 1 | 16,545 | Medium | staphylococcin C55 α/staphylococcin C55 β | ribosomal:RiPP:Lanthipeptide
Region 39.1 | RRE-containing | 1 | 14,256 |
Region 56.1 | NI-siderophore | 83,187 | 114,894 | High | petrobactin | other:other
Region 58.1 | terpene-precursor | 205,238 | 226,128 |  |
Region 60.1 | azole-containing-RiPP | 260,245 | 283,751 |

No secondary metabolite regions were found in these records:
  NZ_NUIO01000021.1 (Bacillus thuringiensis)
  NZ_NUIO01000022.1 (Bacillus thuringiensis)
  NZ_NUIO01000012.1 (Bacillus thuringiensis)
  NZ_NUIO01000013.1 (Bacillus thuringiensis)
  NZ_NUIO01000014.1 (Bacillus thuringiensis)
  NZ_NUIO01000015.1 (Bacillus thuringiensis)
  NZ_NUIO01000016.1 (Bacillus thuringiensis)
  NZ_NUIO01000006.1 (Bacillus thuringiensis)
  NZ_NUIO01000018.1 (Bacillus thuringiensis)
  NZ_NUIO01000019.1 (Bacillus thuringiensis)
  NZ_NUIO01000020.1 (Bacillus thuringiensis)
  NZ_NUIO01000024.1 (Bacillus thuringiensis)
  NZ_NUIO01000025.1 (Bacillus thuringiensis)
  NZ_NUIO01000026.1 (Bacillus thuringiensis)
  NZ_NUIO01000078.1 (Bacillus thuringiensis)
  NZ_NUIO01000079.1 (Bacillus thuringiensis)
  NZ_NUIO01000007.1 (Bacillus thuringiensis)
  NZ_NUIO01000071.1 (Bacillus thuringiensis)
  NZ_NUIO01000072.1 (Bacillus thuringiensis)
  NZ_NUIO01000073.1 (Bacillus thuringiensis)
  NZ_NUIO01000074.1 (Bacillus thuringiensis)
  NZ_NUIO01000075.1 (Bacillus thuringiensis)
  NZ_NUIO01000076.1 (Bacillus thuringiensis)
  NZ_NUIO01000027.1 (Bacillus thuringiensis)
  NZ_NUIO01000028.1 (Bacillus thuringiensis)
  NZ_NUIO01000003.1 (Bacillus thuringiensis)
  NZ_NUIO01000029.1 (Bacillus thuringiensis)
  NZ_NUIO01000030.1 (Bacillus thuringiensis)
  NZ_NUIO01000032.1 (Bacillus thuringiensis)
  NZ_NUIO01000033.1 (Bacillus thuringiensis)
  NZ_NUIO01000035.1 (Bacillus thuringiensis)
  NZ_NUIO01000036.1 (Bacillus thuringiensis)
  NZ_NUIO01000037.1 (Bacillus thuringiensis)
  NZ_NUIO01000038.1 (Bacillus thuringiensis)
  NZ_NUIO01000004.1 (Bacillus thuringiensis)
  NZ_NUIO01000039.1 (Bacillus thuringiensis)
  NZ_NUIO01000040.1 (Bacillus thuringiensis)
  NZ_NUIO01000041.1 (Bacillus thuringiensis)
  NZ_NUIO01000042.1 (Bacillus thuringiensis)
  NZ_NUIO01000043.1 (Bacillus thuringiensis)
  NZ_NUIO01000044.1 (Bacillus thuringiensis)
  NZ_NUIO01000005.1 (Bacillus thuringiensis)
  NZ_NUIO01000049.1 (Bacillus thuringiensis)
  NZ_NUIO01000050.1 (Bacillus thuringiensis)
  NZ_NUIO01000051.1 (Bacillus thuringiensis)
  NZ_NUIO01000058.1 (Bacillus thuringiensis)
  NZ_NUIO01000060.1 (Bacillus thuringiensis)
  NZ_NUIO01000001.1 (Bacillus thuringiensis)

Compact view
NZ_NUIO01000023.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 180,283 - 227,299 nt. (total: 47,017 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
CN977_RS20200: FAD dependent oxidoreductase

smcogs
  SMCOG1103: FAD dependent oxidoreductase

Transferases: aminotransferase glycosyltransferase
CN977_RS20070: aminotransferase

smcogs
  SMCOG1019: aminotransferase

CN977_RS20215: glycosyltransferase, MGT family

smcogs
  SMCOG1062: glycosyltransferase, MGT family

Hydrolases: esterase glucanase hydrolase
CN977_RS20065: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

CN977_RS20105: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs
  SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

CN977_RS20115: Pullulanase, type I

smcogs
  SMCOG1297: Pullulanase, type I

CN977_RS20135: alpha/beta hydrolase domain-containing protein

smcogs
  SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: decarboxylase
CN977_RS20130: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase
CN977_RS20125: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.5 |  | 0.72 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.65 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002286.3 |  | 0.63 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.5 |  | 0.72 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.65 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002286.3 |  | 0.63 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.66 out of 25.88
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.58 out of 20.97
Confidence: medium
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 28.23 out of 31.73
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25
Confidence: medium
Additional weak hits (6):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.36 out of 33.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.46 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.76 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.69 out of 31.73
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.02 out of 32.74
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.63 out of 29.65
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 180282 - 227299:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - Cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CN977_RS20125: X - Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (268..658): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FVMAFDISLLELESLLAGELNIYGPTETTICATV
  Nearest Stachelhaus code(s):
    Ala DILICALICK (44% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1305..1685): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDISFDLSVYDGNTLHSGDVSLGGATEASIWSIY
  Nearest Stachelhaus code(s):
    Cys DLYNLSLIWK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CcpA | Catabolite control protein A
ColR | Phenol-responsive regulator
HexR | Glucose-responsive regulator
PsrA | Oleic acid responsive regulator

NZ_NUIO01000010.1 - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 92,084 - 135,665 nt. (total: 43,582 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidase
CN977_RS13135: FAD linked oxidase domain protein

smcogs
  SMCOG1138: FAD linked oxidase domain protein

Transferases: phosphorylase phosphotransferase
CN977_RS13145: Glucose-specific phosphotransferase enzyme IIA

smcogs
  SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

CN977_RS13170: thiamine-phosphate pyrophosphorylase

smcogs
  SMCOG1280: thiamine-phosphate pyrophosphorylase

Hydrolases: glucosidase
CN977_RS13140: Alpha-glucosidase

smcogs
  SMCOG1257: Alpha-glucosidase

Ligases: ligase
CN977_RS13185: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.61 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000307.4 |  | 0.60 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001132.4 |  | 0.60 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  | 0.60 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.60 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.60 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001261.3 |  | 0.60 | NRPS | AM-toxin | Alternaria alternata
BGC0001758.4 |  | 0.60 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000357.5 |  | 0.60 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001250.4 |  | 0.59 | NRPS | epichloenin A | Epichloe festucae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.61 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000307.4 |  | 0.60 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001132.4 |  | 0.60 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  | 0.60 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.60 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.60 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001261.3 |  | 0.60 | NRPS | AM-toxin | Alternaria alternata
BGC0001758.4 |  | 0.60 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000357.5 |  | 0.60 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001250.4 |  | 0.59 | NRPS | epichloenin A | Epichloe festucae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.69 out of 21.55
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.99 out of 29.38
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.96 out of 20.97
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.78 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19
Confidence: strong
Additional weak hits (9):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.78 out of 31.73
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.11 out of 20.47
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.72 out of 32.74
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.70 out of 25.75
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.98 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 92083 - 135665:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CN977_RS13185: X
AMP-binding (225..621): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWMPFDASVWEAALAIGGEHNVYGPTECTVVTTT
  Nearest Stachelhaus code(s):
    Leu DAWYLGNVVK (71% 8Å match)
  Stachelhaus code match:
    70% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
PsrA | Oleic acid responsive regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_NUIO01000011.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 59,088 - 69,366 nt. (total: 10,279 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
CN977_RS14000: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.

No matches found.

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.32 out of 26.06
Confidence: strong
Additional weak hits (2):
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 36.53
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.53 out of 29.25
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes

NZ_NUIO01000017.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 7,209 - 73,117 nt. (total: 65,909 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidase
CN977_RS15255: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

CN977_RS15395: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

CN977_RS15465: nucleotide sugar dehydrogenase

smcogs
  SMCOG1152: nucleotide sugar dehydrogenase

Transferases: PPTase acetyltransferase acyltransferase aminotransferase
CN977_RS15340: Chloramphenicol acetyltransferase

smcogs
  SMCOG1156: Chloramphenicol acetyltransferase

CN977_RS15350: acyltransferase 3

smcogs
  SMCOG1088: acyltransferase 3

CN977_RS15385: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

CN977_RS15450: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

CN977_RS15470: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Hydrolases: deacetylase esterase
CN977_RS15300: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

CN977_RS15390: thioesterase

smcogs
  SMCOG1004: thioesterase

Lyases: dehydratase
CN977_RS15475: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Isomerases: mutase
CN977_RS15270: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Ligases: ligase
CN977_RS15365: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

CN977_RS15370: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

CN977_RS15380: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.73 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001758.4 |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.73 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001758.4 |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.03 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06
Confidence: strong
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 26.19 out of 30.25
Confidence: medium
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.20 out of 20.01
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.02 out of 23.79
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.92 out of 27.78
Confidence: medium
Additional weak hits (6):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.17 out of 31.73
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.27 out of 36.53
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.02 out of 26.85
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 7208 - 73117:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Thr) + (X - Ala) + (Ser - Leu - D-X - Glu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CN977_RS15365: Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (457..866): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

CN977_RS15370: X - Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (466..870): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWMTFDVSVWEWQFFSGGETNFYGPTEATIYVNA
  Nearest Stachelhaus code(s):
    Glu DVWHFGRINK (71% 8Å match)
    Gln DAWQFGLIDK (65% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1527..1919): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    ala (Ala)

Stachelhaus prediction details:
  Stachelhaus sequence:
    MWATFDLSVFEVNTNLAGEYNLYGPSEDTTYSTY
  Nearest Stachelhaus code(s):
    Ala DLFNNALTYK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

CN977_RS15380: Ser - Leu - X - Glu
Search NORINE for peptide: strict or relaxed
AMP-binding (496..901): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFTSGEINLYGPTEATVDVTY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1558..1945): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    MWHAFDSAVQEPFAITGGDINQYGPSENTVVTTD
  Nearest Stachelhaus code(s):
    Pro DVQFIAQVVK (56% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (2600..3000): X
nrpys: Gln, Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDASIQQMDILVGGEYNVYGPTECTVDATC
  Nearest Stachelhaus code(s):
    Gln or Glu DAQDLGVVDK (88% 8Å match)
    Ile DAQDLGVVDK (85% 8Å match)
    Gln DAQDLGVVDK (79% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (4115..4515): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDVSIQQMDMLVGGEYNVYGPTECTVDATC
  Nearest Stachelhaus code(s):
    Gln or Glu DAQDLGVVDK (85% 8Å match)
    Ile DAQDLGVVDK (82% 8Å match)
    Gln DAQDLGVVDK (76% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArgR | Regulator of arginine biosynthesis genes
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
IolR | Regulator of the inositol catabolism
MogR | Repressor of flagellar motility genes

NZ_NUIO01000077.1 - Region 1 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 203,916 - 255,664 nt. (total: 51,749 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
CN977_RS27860: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

CN977_RS27865: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

CN977_RS27870: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

CN977_RS27935: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

CN977_RS28015: Antibiotic biosynthesis monooxygenase

smcogs
  SMCOG1258: Antibiotic biosynthesis monooxygenase

Transferases: PPTase
CN977_RS27970: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase protease
CN977_RS27950: isochorismatase

smcogs
  SMCOG1027: isochorismatase

CN977_RS27995: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: hydratase
CN977_RS27880: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Isomerases: isomerase
CN977_RS27940: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase synthase
CN977_RS27945: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

CN977_RS27955: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

CN977_RS28020: Pseudouridine synthase

smcogs
  SMCOG1154: Pseudouridine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001185.5 |  |  | 1.05 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  |  | 0.89 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  |  | 0.87 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  |  | 0.86 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  |  | 0.85 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  |  | 0.77 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  |  | 0.74 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  | 0.72 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.5 |  | 0.80 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  | 0.75 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  | 0.74 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  | 0.74 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.69 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.13 out of 27.78
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06
Confidence: strong
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.21 out of 30.25
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.53 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.40 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.41 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.90 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.62 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.57 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.56 out of 29.38
Confidence: medium
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.57 out of 32.74
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.99 out of 30.25
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.69 out of 32.93
Confidence: medium
Additional weak hits (7):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.83 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.49 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.05 out of 29.38
Confidence: weak
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.72 out of 18.46
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.35 out of 31.73
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.54 out of 30.25
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 203915 - 255664:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CN977_RS27945: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (31..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SVSLYPMSSPGGALQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PMPAQGVVNK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

CN977_RS27955: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (464..864): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FAMTFDISALELQALVGGETNLYGPTETTIWSTF
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1524..1937): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LATHFDFSVWEGNQVFGGEINMYGITETTVHVSY
  Nearest Stachelhaus code(s):
    Thr DFWNVGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
FuR variant 2 | Ferric Uptake Regulator
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_NUIO01000080.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 133,513 - 155,366 nt. (total: 21,854 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
CN977_RS29490: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

CN977_RS29495: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Lyases: lyase
CN977_RS29520: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000917.3 |  | 0.53 | other (other) | molybdenum cofactor | Rhodobacter capsulatus
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001928.2 |  | 0.46 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000916.5 |  | 0.46 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0000812.3 |  | 0.45 | other (other) | huperzine A | Shiraia sp. slf14
BGC0000231.5 |  | 0.42 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0001605.3 |  | 0.42 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001197.5 |  | 0.42 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000234.5 |  | 0.41 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002138.2 |  | 0.40 | PKS | fuelimycin A, fuelimicin B, fuelimicin C | Streptomyces albireticuli NRRL B-1670

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000917.3 |  | 0.53 | other (other) | molybdenum cofactor | Rhodobacter capsulatus
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001928.2 |  | 0.46 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000916.5 |  | 0.46 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0000812.3 |  | 0.45 | other (other) | huperzine A | Shiraia sp. slf14
BGC0000231.5 |  | 0.42 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0001605.3 |  | 0.42 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001197.5 |  | 0.42 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000234.5 |  | 0.41 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002138.2 |  | 0.40 | PKS | fuelimycin A, fuelimicin B, fuelimicin C | Streptomyces albireticuli NRRL B-1670

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
CN977_RS29480: T2TS
Domain 1 (4 - 614): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 26.42 out of 30.22
Confidence: medium
Additional weak hits (1):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.61 out of 36.54
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ClgR | Caseinolytic protease gene regulator

NZ_NUIO01000070.1 - Region 1 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 14,721 - 39,959 nt. (total: 25,239 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
CN977_RS24495: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase carboxylase transferase
CN977_RS24500: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

CN977_RS24520: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

CN977_RS24540: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Lyases: hydratase
CN977_RS24515: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
CN977_RS24510: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

CN977_RS24525: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002284.3 |  | 0.55 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000131.5 |  | 0.46 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0000706.3 |  | 0.46 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000234.5 |  | 0.43 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001103.5 |  | 0.42 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001226.4 |  | 0.42 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002284.3 |  | 0.55 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000131.5 |  | 0.46 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0000706.3 |  | 0.46 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000234.5 |  | 0.43 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001103.5 |  | 0.42 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001226.4 |  | 0.42 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26
Confidence: strong
Additional weak hits (2):
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.69 out of 30.12
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.04 out of 30.12
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein

NZ_NUIO01000070.1 - Region 2 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 91,187 - 101,516 nt. (total: 10,330 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
CN977_RS24835: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000896.5 |  | 0.29 | other (other) | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000721.4 |  | 0.26 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0000172.5 |  | 0.23 | PKS | Basiliskamide A, Basiliskamide B | Brevibacillus laterosporus PE36
BGC0000381.5 |  | 0.23 | NRPS | lichenysin | Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5 |  | 0.22 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0000455.6 |  | 0.22 | NRPS, saccharide | vancomycin | Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2 |  | 0.22 | other (other) | enduracididine | uncultured bacterium
BGC0001233.5 |  | 0.22 | NRPS | feglymycin | Streptomyces sp. DSM 11171
BGC0001461.5 |  | 0.21 | NRPS | Actinoidin B | Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5 |  | 0.21 | NRPS | decaplanin | Amycolatopsis regifaucium

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000896.5 |  | 0.29 | other (other) | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000721.4 |  | 0.26 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0000172.5 |  | 0.23 | PKS | Basiliskamide A, Basiliskamide B | Brevibacillus laterosporus PE36
BGC0000381.5 |  | 0.23 | NRPS | lichenysin | Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5 |  | 0.22 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0000455.6 |  | 0.22 | NRPS, saccharide | vancomycin | Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2 |  | 0.22 | other (other) | enduracididine | uncultured bacterium
BGC0001233.5 |  | 0.22 | NRPS | feglymycin | Streptomyces sp. DSM 11171
BGC0001461.5 |  | 0.21 | NRPS | Actinoidin B | Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5 |  | 0.21 | NRPS | decaplanin | Amycolatopsis regifaucium

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.87 out of 32.93
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.22 out of 24.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06
Confidence: medium
Additional weak hits (2):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.35 out of 30.12
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 2 | Repressor of DNA damage response
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes

NZ_NUIO01000031.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 16,545 nt. (total: 16,545 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
CN977_RS23185: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Lyases: cyclase
CN977_RS23170: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

CN977_RS23180: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000520.5 |  | 0.78 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000555.3 |  | 0.68 | ribosomal | staphylococcin C55 α, staphylococcin C55 β | Staphylococcus aureus
BGC0001229.4 |  | 0.63 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002110.3 |  | 0.61 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000517.4 |  | 0.60 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000516.4 |  | 0.50 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0001391.3 |  | 0.50 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0001311.5 |  | 0.49 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000626.3 |  | 0.48 | ribosomal | thuricin | Bacillus thuringiensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000520.5 |  | 0.78 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000555.3 |  | 0.68 | ribosomal | staphylococcin C55 α, staphylococcin C55 β | Staphylococcus aureus
BGC0001229.4 |  | 0.63 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002110.3 |  | 0.61 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000517.4 |  | 0.60 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000516.4 |  | 0.50 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0001391.3 |  | 0.50 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0001311.5 |  | 0.49 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000626.3 |  | 0.48 | ribosomal | thuricin | Bacillus thuringiensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for CN977_RS23170

CN977_RS23160
Leader:
MKNEISKEVQLAQVTWLEEVVDQEFDDDVFGA
Core:
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
Core with dehydrations:
Cys Dhb Dhb N Dhb F Dha L Dha D Y W G N D G Dha W Cys Dhb A Dhb H E Cys L Dha W Cys K

#### antiSMASH-DB 4.0 matches for CN977_RS23160

100.0%
NZ_NUIO01000031.1 and 1 other:
NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide
Lanthipeptides: CN977_RS23160_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
90.0%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide
Lanthipeptides: IE339_RS06330_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C T T N T F S L S D Y W G N G W C T A T H E C+S W C K
1
C T T N T F S L S D Y W G N K G G W C T A T H E C M S W C K
30
90.0%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide
Lanthipeptides: CQS04_RS09620_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C T T N T F S L S D Y W G N+G+W C T A T H E C+S W C K
1
C T T N T F S L S D Y W G N N G N W C T A T H E C M S W C K
30
with 102 more sequence matches
Only the first 10 are displayed here.
86.7%
NZ_AP026714.1 and 21 others:
NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide
Lanthipeptides: PO853_RS06515_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C T T N T F S L S D Y W G N G+W C T A T H E C+ W C K
1
C T T N T F S L S D Y W G N K G N W C T A T H E C M G W C K
30
86.7%
NZ_MIFN01000022.1 and 1 other:
NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide
Lanthipeptides: BHL26_RS15350_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C T T N T F S L S D Y W G N D G S W C+ +H E C+S W C K
1
C T T N T F S L S D Y W G N D G S W C S L S H E C M S W C K
30
83.3%
NZ_BLIS01000009.1 and 7 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptide NZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptide NZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide
Lanthipeptides: GVO03_RS04820_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C T T N T F S L S D Y W G N G+W C T T H E C++W C K
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
83.3%
NZ_CP027862.1 and 1 other:
NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide
Lanthipeptides: allorf_0097945_0098112_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C+T N T F S L S D Y W G N G W C T T H E C+S W C K
1
C S T N T F S L S D Y W G N R G Y W C T L T H E C M S W C K
30
83.3%
NZ_FMPI01000012.1 and 1 other:
NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide
Lanthipeptides: BJR39_RS08305_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C+T N T F S L S D Y W G N+G+W C T A+H E C+S W C K
1
C S T N T F S L S D Y W G N N G N W C T A S H E C M S W C K
30
80.0%
NZ_CP034414.1 and 1 other:
NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide
Lanthipeptides: EI692_RS18440_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C+T N T F S L S D Y W G N G W C T +H E C+S W C K
1
C S T N T F S L S D Y W G N K G G W C T I S H E C M S W C K
30
80.0%
NZ_CP051884.1 and 2 others:
NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide
Lanthipeptides: HGK68_RS15125_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C+T N T F S L S D Y W G N+G C T T H E C+S W C K
1
C S T N T F S L S D Y W G N N G W L C T I T H E C M S W C K
30
76.7%
NZ_CACZYW010000004.1 and 1 other:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide
Lanthipeptides: HUF10_RS02825_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C+T N T F S L S D Y W G N+G+W C T +H E C++W C K
1
C S T N T F S L S D Y W G N N G N W C T L S H E C M A W C K
30
76.7%
NZ_QGEE01000020.1 and 5 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptide NZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptide NZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide
Lanthipeptides: DKP74_RS06160_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C+T N T F S L S D Y W G N G+W C T +H E C++W C K
1
C S T N T F S L S D Y W G N R G N W C T L S H E C M A W C K
30
73.3%
NZ_CP016767.1 and 11 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13410_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide
Lanthipeptides: BCV50_RS13410_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C
29
C T T N T F S L S D Y W G N G W C T + E C++W C
1
C T T N T F S L S D Y W G N K G G W C T V S K E C M A W C
29

#### MIBiG 4.0 matches for CN977_RS23160

63.3%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C T T N T F S L S+ G N+G W C T T E C C
1
C T T N T F S L S N A L G N N G G W C T L T K E C Q P N C N
30
33.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
F S L S D Y W G N D G S W C T A T H E C L S W C
29
+++S G N G++C T T E C+ C
4
Y N I S C R L G N K G A Y C T L T V E C M P S C
27
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
19
C T A T H E C L S W C
29
C T + E C C
28
C T L S K E C Q P N C
38
CN977_RS23165
Leader:
MNNNKSNTNNSLKNELELGKYLESDMIALTEDDVAGG
Core:
I T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
Core with dehydrations:
I Dhb P Dhb V Dha I A L Dhb A V Dha G Y I Dha Dha N Dhb Cys P Dhb Dhb A Cys Dhb R A Cys

#### antiSMASH-DB 4.0 matches for CN977_RS23165

100.0%
NZ_NUIO01000031.1 and 1 other:
NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide
Lanthipeptides: CN977_RS23165_lanthipeptide
1
I T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
I T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
1
I T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
81.8%
NZ_MIFN01000022.1 and 1 other:
NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide
Lanthipeptides: BHL26_RS15355_lanthipeptide
1
I T P T V---S I A L T A V S G Y I S S N T C P T T A C T R A C
30
I T P T V + A L T A V S G Y I S S N T C P+T A C T R A C
1
I T P T V L A T T G A L T A V S G Y I S S N T C P S T A C T R A C
33
76.7%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide
Lanthipeptides: IE339_RS06335_lanthipeptide
1
I T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
I T P T I +T A V+G Y I S+N T C P T T+C T R A C
1
I T P T--I V I T A V T G Y I S T N T C P T T S C T R A C
28
with 85 more sequence matches
Only the first 10 are displayed here.
66.7%
NZ_CP034414.1 and 1 other:
NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide
Lanthipeptides: EI692_RS18435_lanthipeptide
1
I T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
+T P +S I V S G+I S+N T C P+T A C T R A C
1
V T P A I S I L---V S G F I S T N T C P S T A C T R A C
27
63.3%
NZ_CP016767.1 and 3 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide
Lanthipeptides: BCV50_RS13415_lanthipeptide
8
A L T A V S G Y I S S N T C P T T A C T R A C
30
A L+ ++G Y I S S N T C P T T A C T R A C
4
A L S V I T G Y I S S N T C P T T A C T R A C
26
63.3%
NZ_CP051884.1 and 3 others:
NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide
Lanthipeptides: HGK68_RS15130_lanthipeptide
2
T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
T P T V L+ V S +I S+N T C P++A C T R A C
2
T P T V--V L S I V S A W I S N N T C P S S A C T R A C
28
63.3%
NZ_JALAPU010000003.1 and 7 others:
NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide
Lanthipeptides: MOD17_RS07925_lanthipeptide
8
A L T A V S G Y I S S N T C P T T A C T R A C
30
A L+ V+ Y I S S N T C P T T A C T R A C
4
A L S V V T A Y I S S N T C P T T A C T R A C
26
63.3%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide
Lanthipeptides: CQS04_RS09625_lanthipeptide
4
T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
T +I +T A++G Y I S+N+C P T T A C T R A C
2
T P T I V I T A I T G Y I S A N S C P T T A C T R A C
28
61.3%
NZ_AP026714.1 and 21 others:
NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide
Lanthipeptides: PO853_RS06520_lanthipeptide
2
T P T V S I A L T-A V S G Y I S S N T C P T T A C T R A C
30
T P T++I ++ A V S G+I S T C P T+ C T R A C
2
T P T I T I P I S I A V S G W I S D K T C P T S V C T R A C
31
60.0%
NZ_QGEE01000020.1 and 3 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide
Lanthipeptides: DKP74_RS06165_lanthipeptide
2
T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
T P + + V S G++S S+T C P T T A C T R A C
2
T P V I G Y S A V I V S G F V S S H T C P T T A C T R A C
30
59.4%
NZ_FMPI01000012.1 and 1 other:
NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08310_lanthipeptide
Lanthipeptides: BJR39_RS08310_lanthipeptide
2
T P T V S I A L T A--V S G Y I S S N T C P T T A C T R A C
30
T P T +A A V Y+S+ T C P T T A C T R A C
2
T P T A L L A G A A G G V V T Y V S N Q T C P T T A C T R A C
32
56.7%
NZ_KE384533.1 and 2 others:
NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide
Lanthipeptides: K329_RS31315_lanthipeptide
2
T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
T P T+ I++ V S Y+S+N T C P T T+C T C
1
T P T I V I S V--V S A Y V S T N T C P T T S C T D E C
27
54.5%
NZ_LR134317.1 and 1 other:
NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide
Lanthipeptides: EL136_RS01690_lanthipeptide
2
T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
T P + A A V+ +I S+N T C P T T+C T R A C
5
T P W L V K A S V A V T A F I S A N T C P T T S C T R A C
33

#### MIBiG 4.0 matches for CN977_RS23165

23.3%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
21
C P T T A C T R A C
30
C P T T C T C
17
C P T T K C T S K C
26
21.6%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
16
I S S N T C P T T A C T R A C
30
+S+ C P T T C T C
23
V S A A F C P T T K C T S R C
37
allorf_00879_00956
Leader:
MDTSVFAG
Core:
I S H F K Q S V R T V Q T V K C K
Core with dehydrations:
I Dha H F K Q Dha V R Dhb V Q Dhb V K Cys K

#### antiSMASH-DB 4.0 matches for allorf_00879_00956

100.0%
NZ_NUIO01000031.1:
Lanthipeptides: allorf_00879_00956_lanthipeptide
1
I S H F K Q S V R T V Q T V K C K
17
I S H F K Q S V R T V Q T V K C K
1
I S H F K Q S V R T V Q T V K C K
17
allorf_01256_01357
Leader:
MIINPFISFLKEYQAS
Core:
T F L D C I L V S H K K S F P V M
Core with dehydrations:
Dhb F L D Cys I L V Dha H K K Dha F P V M

#### antiSMASH-DB 4.0 matches for allorf_01256_01357

100.0%
NZ_MIFN01000022.1 and 3 others:
NZ_MIFN01000022.1 Lanthipeptides: allorf_54314_54415_lanthipeptide NZ_NUIO01000031.1 Lanthipeptides: allorf_01256_01357_lanthipeptide NZ_NUIO01000031.1 Lanthipeptides: allorf_01256_01357_lanthipeptide
Lanthipeptides: allorf_54314_54415_lanthipeptide
1
T F L D C I L V S H K K S F P V M
17
T F L D C I L V S H K K S F P V M
1
T F L D C I L V S H K K S F P V M
17
94.1%
NZ_NTSR01000029.1:
Lanthipeptides: allorf_71672_71773_lanthipeptide
1
T F L D C I L V S H K K S F P V M
17
T F L D C I L V S H K K F P V M
1
T F L D C I L V S H K K G F P V M
17
20.0%
NZ_CP009913.1 and 1 other:
NZ_LR793265.1 Lanthipeptides: HV392_RS09820_lanthipeptide
Lanthipeptides: SSAL8618_RS10260_lanthipeptide
3
L D C I L V S H K K S F P
15
L C L++H F P
17
L G C N L L T H G C R F P
29

#### Lanthipeptide(s) for CN977_RS23180

CN977_RS23160
Leader:
MKNEISKEVQLAQVTWLEEVVDQEFDDDVFGA
Core:
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
Core with dehydrations:
Cys Dhb Dhb N Dhb F Dha L Dha D Y W G N D G Dha W Cys Dhb A Dhb H E Cys L Dha W Cys K

#### antiSMASH-DB 4.0 matches for CN977_RS23160

100.0%
NZ_NUIO01000031.1 and 1 other:
NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide
Lanthipeptides: CN977_RS23160_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
90.0%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide
Lanthipeptides: IE339_RS06330_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C T T N T F S L S D Y W G N G W C T A T H E C+S W C K
1
C T T N T F S L S D Y W G N K G G W C T A T H E C M S W C K
30
90.0%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide
Lanthipeptides: CQS04_RS09620_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C T T N T F S L S D Y W G N+G+W C T A T H E C+S W C K
1
C T T N T F S L S D Y W G N N G N W C T A T H E C M S W C K
30
with 102 more sequence matches
Only the first 10 are displayed here.
86.7%
NZ_AP026714.1 and 21 others:
NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide
Lanthipeptides: PO853_RS06515_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C T T N T F S L S D Y W G N G+W C T A T H E C+ W C K
1
C T T N T F S L S D Y W G N K G N W C T A T H E C M G W C K
30
86.7%
NZ_MIFN01000022.1 and 1 other:
NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide
Lanthipeptides: BHL26_RS15350_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C T T N T F S L S D Y W G N D G S W C+ +H E C+S W C K
1
C T T N T F S L S D Y W G N D G S W C S L S H E C M S W C K
30
83.3%
NZ_BLIS01000009.1 and 7 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptide NZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptide NZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide
Lanthipeptides: GVO03_RS04820_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C T T N T F S L S D Y W G N G+W C T T H E C++W C K
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
83.3%
NZ_CP027862.1 and 1 other:
NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide
Lanthipeptides: allorf_0097945_0098112_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C+T N T F S L S D Y W G N G W C T T H E C+S W C K
1
C S T N T F S L S D Y W G N R G Y W C T L T H E C M S W C K
30
83.3%
NZ_FMPI01000012.1 and 1 other:
NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide
Lanthipeptides: BJR39_RS08305_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C+T N T F S L S D Y W G N+G+W C T A+H E C+S W C K
1
C S T N T F S L S D Y W G N N G N W C T A S H E C M S W C K
30
80.0%
NZ_CP034414.1 and 1 other:
NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide
Lanthipeptides: EI692_RS18440_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C+T N T F S L S D Y W G N G W C T +H E C+S W C K
1
C S T N T F S L S D Y W G N K G G W C T I S H E C M S W C K
30
80.0%
NZ_CP051884.1 and 2 others:
NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide
Lanthipeptides: HGK68_RS15125_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C+T N T F S L S D Y W G N+G C T T H E C+S W C K
1
C S T N T F S L S D Y W G N N G W L C T I T H E C M S W C K
30
76.7%
NZ_CACZYW010000004.1 and 1 other:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide
Lanthipeptides: HUF10_RS02825_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C+T N T F S L S D Y W G N+G+W C T +H E C++W C K
1
C S T N T F S L S D Y W G N N G N W C T L S H E C M A W C K
30
76.7%
NZ_QGEE01000020.1 and 5 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptide NZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptide NZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide
Lanthipeptides: DKP74_RS06160_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C+T N T F S L S D Y W G N G+W C T +H E C++W C K
1
C S T N T F S L S D Y W G N R G N W C T L S H E C M A W C K
30
73.3%
NZ_CP016767.1 and 11 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13410_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide
Lanthipeptides: BCV50_RS13410_lanthipeptide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C
29
C T T N T F S L S D Y W G N G W C T + E C++W C
1
C T T N T F S L S D Y W G N K G G W C T V S K E C M A W C
29

#### MIBiG 4.0 matches for CN977_RS23160

63.3%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
C T T N T F S L S+ G N+G W C T T E C C
1
C T T N T F S L S N A L G N N G G W C T L T K E C Q P N C N
30
33.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
F S L S D Y W G N D G S W C T A T H E C L S W C
29
+++S G N G++C T T E C+ C
4
Y N I S C R L G N K G A Y C T L T V E C M P S C
27
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
19
C T A T H E C L S W C
29
C T + E C C
28
C T L S K E C Q P N C
38
CN977_RS23165
Leader:
MNNNKSNTNNSLKNELELGKYLESDMIALTEDDVAGG
Core:
I T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
Core with dehydrations:
I Dhb P Dhb V Dha I A L Dhb A V Dha G Y I Dha Dha N Dhb Cys P Dhb Dhb A Cys Dhb R A Cys

#### antiSMASH-DB 4.0 matches for CN977_RS23165

100.0%
NZ_NUIO01000031.1 and 1 other:
NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide
Lanthipeptides: CN977_RS23165_lanthipeptide
1
I T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
I T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
1
I T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
81.8%
NZ_MIFN01000022.1 and 1 other:
NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide
Lanthipeptides: BHL26_RS15355_lanthipeptide
1
I T P T V---S I A L T A V S G Y I S S N T C P T T A C T R A C
30
I T P T V + A L T A V S G Y I S S N T C P+T A C T R A C
1
I T P T V L A T T G A L T A V S G Y I S S N T C P S T A C T R A C
33
76.7%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide
Lanthipeptides: IE339_RS06335_lanthipeptide
1
I T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
I T P T I +T A V+G Y I S+N T C P T T+C T R A C
1
I T P T--I V I T A V T G Y I S T N T C P T T S C T R A C
28
with 85 more sequence matches
Only the first 10 are displayed here.
66.7%
NZ_CP034414.1 and 1 other:
NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide
Lanthipeptides: EI692_RS18435_lanthipeptide
1
I T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
+T P +S I V S G+I S+N T C P+T A C T R A C
1
V T P A I S I L---V S G F I S T N T C P S T A C T R A C
27
63.3%
NZ_CP016767.1 and 3 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide
Lanthipeptides: BCV50_RS13415_lanthipeptide
8
A L T A V S G Y I S S N T C P T T A C T R A C
30
A L+ ++G Y I S S N T C P T T A C T R A C
4
A L S V I T G Y I S S N T C P T T A C T R A C
26
63.3%
NZ_CP051884.1 and 3 others:
NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide
Lanthipeptides: HGK68_RS15130_lanthipeptide
2
T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
T P T V L+ V S +I S+N T C P++A C T R A C
2
T P T V--V L S I V S A W I S N N T C P S S A C T R A C
28
63.3%
NZ_JALAPU010000003.1 and 7 others:
NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide
Lanthipeptides: MOD17_RS07925_lanthipeptide
8
A L T A V S G Y I S S N T C P T T A C T R A C
30
A L+ V+ Y I S S N T C P T T A C T R A C
4
A L S V V T A Y I S S N T C P T T A C T R A C
26
63.3%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide
Lanthipeptides: CQS04_RS09625_lanthipeptide
4
T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
T +I +T A++G Y I S+N+C P T T A C T R A C
2
T P T I V I T A I T G Y I S A N S C P T T A C T R A C
28
61.3%
NZ_AP026714.1 and 21 others:
NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide
Lanthipeptides: PO853_RS06520_lanthipeptide
2
T P T V S I A L T-A V S G Y I S S N T C P T T A C T R A C
30
T P T++I ++ A V S G+I S T C P T+ C T R A C
2
T P T I T I P I S I A V S G W I S D K T C P T S V C T R A C
31
60.0%
NZ_QGEE01000020.1 and 3 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide
Lanthipeptides: DKP74_RS06165_lanthipeptide
2
T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
T P + + V S G++S S+T C P T T A C T R A C
2
T P V I G Y S A V I V S G F V S S H T C P T T A C T R A C
30
59.4%
NZ_FMPI01000012.1 and 1 other:
NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08310_lanthipeptide
Lanthipeptides: BJR39_RS08310_lanthipeptide
2
T P T V S I A L T A--V S G Y I S S N T C P T T A C T R A C
30
T P T +A A V Y+S+ T C P T T A C T R A C
2
T P T A L L A G A A G G V V T Y V S N Q T C P T T A C T R A C
32
56.7%
NZ_KE384533.1 and 2 others:
NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide
Lanthipeptides: K329_RS31315_lanthipeptide
2
T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
T P T+ I++ V S Y+S+N T C P T T+C T C
1
T P T I V I S V--V S A Y V S T N T C P T T S C T D E C
27
54.5%
NZ_LR134317.1 and 1 other:
NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide
Lanthipeptides: EL136_RS01690_lanthipeptide
2
T P T V S I A L T A V S G Y I S S N T C P T T A C T R A C
30
T P + A A V+ +I S+N T C P T T+C T R A C
5
T P W L V K A S V A V T A F I S A N T C P T T S C T R A C
33

#### MIBiG 4.0 matches for CN977_RS23165

23.3%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
21
C P T T A C T R A C
30
C P T T C T C
17
C P T T K C T S K C
26
21.6%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
16
I S S N T C P T T A C T R A C
30
+S+ C P T T C T C
23
V S A A F C P T T K C T S R C
37
allorf_01256_01357
Leader:
MIINPFISFLKEYQAS
Core:
T F L D C I L V S H K K S F P V M
Core with dehydrations:
Dhb F L D Cys I L V Dha H K K Dha F P V M

#### antiSMASH-DB 4.0 matches for allorf_01256_01357

100.0%
NZ_MIFN01000022.1 and 3 others:
NZ_MIFN01000022.1 Lanthipeptides: allorf_54314_54415_lanthipeptide NZ_NUIO01000031.1 Lanthipeptides: allorf_01256_01357_lanthipeptide NZ_NUIO01000031.1 Lanthipeptides: allorf_01256_01357_lanthipeptide
Lanthipeptides: allorf_54314_54415_lanthipeptide
1
T F L D C I L V S H K K S F P V M
17
T F L D C I L V S H K K S F P V M
1
T F L D C I L V S H K K S F P V M
17
94.1%
NZ_NTSR01000029.1:
Lanthipeptides: allorf_71672_71773_lanthipeptide
1
T F L D C I L V S H K K S F P V M
17
T F L D C I L V S H K K F P V M
1
T F L D C I L V S H K K G F P V M
17
20.0%
NZ_CP009913.1 and 1 other:
NZ_LR793265.1 Lanthipeptides: HV392_RS09820_lanthipeptide
Lanthipeptides: SSAL8618_RS10260_lanthipeptide
3
L D C I L V S H K K S F P
15
L C L++H F P
17
L G C N L L T H G C R F P
29

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (2):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

CN977_RS23160 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 3253.4 Da
  Molecular weight: 3255.5 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3273.5 Da N = 1
    3291.6 Da N = 2
    3309.6 Da N = 3
    3327.6 Da N = 4
    3345.6 Da N = 5
CN977_RS23165 - Class II
  Cleavage pHMM score: -0.90
  RODEO score: 0
  Monoisotopic mass: 2803.5 Da
  Molecular weight: 2805.2 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2823.2 Da N = 1
    2841.2 Da N = 2
    2859.3 Da N = 3
    2877.3 Da N = 4
    2895.3 Da N = 5
    2913.3 Da N = 6
    2931.3 Da N = 7
    2949.4 Da N = 8
allorf_01256_01357 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 1910.0 Da
  Molecular weight: 1911.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1929.3 Da N = 1
    1947.4 Da N = 2
CN977_RS23160 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 3253.4 Da
  Molecular weight: 3255.5 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3273.5 Da N = 1
    3291.6 Da N = 2
    3309.6 Da N = 3
    3327.6 Da N = 4
    3345.6 Da N = 5
CN977_RS23165 - Class II
  Cleavage pHMM score: -0.90
  RODEO score: 0
  Monoisotopic mass: 2803.5 Da
  Molecular weight: 2805.2 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2823.2 Da N = 1
    2841.2 Da N = 2
    2859.3 Da N = 3
    2877.3 Da N = 4
    2895.3 Da N = 5
    2913.3 Da N = 6
    2931.3 Da N = 7
    2949.4 Da N = 8
allorf_00879_00956 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 1916.1 Da
  Molecular weight: 1917.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1935.3 Da N = 1
    1953.3 Da N = 2
    1971.3 Da N = 3
allorf_01256_01357 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 1910.0 Da
  Molecular weight: 1911.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1929.3 Da N = 1
    1947.4 Da N = 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_NUIO01000034.1 - Region 1 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 14,256 nt. (total: 14,256 nt) Show pHMM detection rules used
Region on contig edge.
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: lyase
CN977_RS23470: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.57 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0002458.3 |  | 0.50 | NRPS | alazopeptin | Streptacidiphilus griseoplanus
BGC0000308.5 |  | 0.43 | NRPS | aureusimine A, aureusimine B, aureusimine C | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001168.5 |  | 0.42 | NRPS | Livipeptin | Streptomyces lividans 1326
BGC0002645.3 |  | 0.42 | other (other) | fluopsin C | Pseudomonas aeruginosa PAO1
BGC0001286.3 |  | 0.40 | other (other) | itaconic acid | Ustilago maydis
BGC0002555.3 |  | 0.40 | NRPS, PKS | emerimicin V, emerimicin VI, emerimicin VII, emerimicin VIII, emerimicin IX, emerimicin X | Acremonium sp.
BGC0001295.5 |  | 0.39 | other (other) | cremeomycin | Streptomyces cremeus
BGC0000937.5 |  | 0.37 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0000430.5 |  | 0.36 | NRPS, PKS | spumigin E, Spumigin E | Nodularia spumigena CCY9414

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.57 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0002458.3 |  | 0.50 | NRPS | alazopeptin | Streptacidiphilus griseoplanus
BGC0000308.5 |  | 0.43 | NRPS | aureusimine A, aureusimine B, aureusimine C | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001168.5 |  | 0.42 | NRPS | Livipeptin | Streptomyces lividans 1326
BGC0002645.3 |  | 0.42 | other (other) | fluopsin C | Pseudomonas aeruginosa PAO1
BGC0001286.3 |  | 0.40 | other (other) | itaconic acid | Ustilago maydis
BGC0002555.3 |  | 0.40 | NRPS, PKS | emerimicin V, emerimicin VI, emerimicin VII, emerimicin VIII, emerimicin IX, emerimicin X | Acremonium sp.
BGC0001295.5 |  | 0.39 | other (other) | cremeomycin | Streptomyces cremeus
BGC0000937.5 |  | 0.37 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0000430.5 |  | 0.36 | NRPS, PKS | spumigin E, Spumigin E | Nodularia spumigena CCY9414

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.94 out of 25.31
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.50 out of 27.78
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.85 out of 30.25
Confidence: medium
Additional weak hits (3):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.40 out of 20.01
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.72 out of 32.93
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

RRE-containing protocluster (0...14256)
CN977_RS23455
  RRE type: Pantocin_Microcin_RRE
  Location: 0 - 95
  Score: 94.5

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator

NZ_NUIO01000008.1 - Region 1 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 83,187 - 114,894 nt. (total: 31,708 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
CN977_RS08580: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: deacetylase
CN977_RS08515: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Ligases: ligase synthase
CN977_RS08490: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

CN977_RS08545: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000942.4 |  | 0.88 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0002469.2 |  | 0.54 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001572.3 |  | 0.51 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0000295.5 |  | 0.51 | NRPS | acinetoferrin | Acinetobacter haemolyticus
BGC0002620.2 |  | 0.50 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0002692.2 |  | 0.50 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002305.2 |  | 0.50 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0001531.5 |  | 0.50 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0001713.5 |  | 0.48 | other (other) | ochrobactin | Ochrobactrum anthropi
BGC0002633.2 |  | 0.47 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000942.4 |  | 0.88 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0002469.2 |  | 0.54 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001572.3 |  | 0.51 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0000295.5 |  | 0.51 | NRPS | acinetoferrin | Acinetobacter haemolyticus
BGC0002620.2 |  | 0.50 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0002692.2 |  | 0.50 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002305.2 |  | 0.50 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0001531.5 |  | 0.50 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0001713.5 |  | 0.48 | other (other) | ochrobactin | Ochrobactrum anthropi
BGC0002633.2 |  | 0.47 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.03 out of 20.97
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.99 out of 30.25
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.38 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.93 out of 28.19
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.13 out of 18.16
Confidence: strong
Additional weak hits (4):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.88 out of 26.12
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.50 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.66 out of 32.74
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.60 out of 36.54
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_NUIO01000009.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 205,238 - 226,128 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
CN977_RS10300: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
CN977_RS10330: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

CN977_RS10335: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
CN977_RS10330: PT_FPPS_like
Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.32 out of 25.88
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.66 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78
Confidence: medium
Additional weak hits (1):
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.40 out of 33.14
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator

NZ_NUIO01000002.1 - Region 1 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 260,245 - 283,751 nt. (total: 23,507 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
CN977_RS01935: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001174.4 |  | 0.44 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0002013.4 |  | 0.44 | ribosomal | curacozole | Streptomyces curacoi
BGC0000607.5 |  | 0.43 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001146.5 |  | 0.41 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0001173.5 |  | 0.41 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000606.5 |  | 0.39 | ribosomal | lactazole | Streptomyces lactacystinaeus
BGC0001145.5 |  | 0.38 | ribosomal | cyclothiazomycin b1 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001640.3 |  | 0.38 | ribosomal | kocurin | Kocuria rosea
BGC0000605.5 |  | 0.38 | ribosomal | GE37468 | Streptomyces sp. ATCC 55365

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001174.4 |  | 0.44 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0002013.4 |  | 0.44 | ribosomal | curacozole | Streptomyces curacoi
BGC0000607.5 |  | 0.43 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001146.5 |  | 0.41 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0001173.5 |  | 0.41 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000606.5 |  | 0.39 | ribosomal | lactazole | Streptomyces lactacystinaeus
BGC0001145.5 |  | 0.38 | ribosomal | cyclothiazomycin b1 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001640.3 |  | 0.38 | ribosomal | kocurin | Kocuria rosea
BGC0000605.5 |  | 0.38 | ribosomal | GE37468 | Streptomyces sp. ATCC 55365

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.38 out of 27.78
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.11 out of 27.55
Confidence: medium
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
RREFinder
TFBS Finder
Azole RiPPs
RRE predictions
RREfinder results sidepanel.

azole-containing-RiPP protocluster (260244...283751)
CN977_RS01910
  RRE type: Heterocycloanthracin_C_RRE
  Location: 0 - 100
  Score: 184.8
  RRE type: Thiopeptide_F_RRE
  Location: 10 - 89
  Score: 41.3

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
MogR | Repressor of flagellar motility genes

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.