GCF_002563475.1 - 6 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_MTJS01000001.1 (Lactococcus lactis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	RaS-RiPP	34,111	56,501

NZ_MTJS01000005.1 (Lactococcus lactis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	RaS-RiPP	121	26,502

NZ_MTJS01000002.1 (Lactococcus lactis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 9.1	T3PKS	442,688	483,842
Region 9.2	terpene-precursor	1,237,049	1,257,906
Region 9.3	lanthipeptide-class-i	1,500,829	1,526,860	High	nisin A	ribosomal:RiPP:Lanthipeptide
Region 9.4	betalactone,RiPP-like	1,527,929	1,564,756

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	RaS-RiPP	34,111	56,501
Region 6.1	RaS-RiPP	121	26,502
Region 9.1	T3PKS	442,688	483,842
Region 9.2	terpene-precursor	1,237,049	1,257,906
Region 9.3	lanthipeptide-class-i	1,500,829	1,526,860	High	nisin A	ribosomal:RiPP:Lanthipeptide
Region 9.4	betalactone,RiPP-like	1,527,929	1,564,756

No secondary metabolite regions were found in these records:: NZ_MTJS01000003.1 (Lactococcus lactis); NZ_MTJS01000011.1 (Lactococcus lactis); NZ_MTJS01000004.1 (Lactococcus lactis); NZ_MTJS01000006.1 (Lactococcus lactis); NZ_MTJS01000007.1 (Lactococcus lactis); NZ_MTJS01000008.1 (Lactococcus lactis)

Compact view

NZ_MTJS01000001.1 - Region 1 - RaS-RiPP

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Location: 34,111 - 56,501 nt. (total: 22,391 nt) Show pHMM detection rules used

RaS-RiPP: (PF04055 and TIGR01716)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

BW154_RS00235: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: aminotransferase

BW154_RS00200: aminotransferase

smcogs: SMCOG1019: aminotransferase

Ligases: synthase

BW154_RS00245: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.63	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001534.3	0.44	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001535.3	0.44	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001929.2	0.43	ribosomal	WGK	Streptococcus ferus
BGC0000571.3	0.41	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002674.2	0.41	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001639.3	0.41	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000543.5	0.40	ribosomal	pep5	Staphylococcus epidermidis
BGC0002701.2	0.39	ribosomal	paenithipeptin	Paenibacillus thiaminolyticus
BGC0001863.4	0.39	ribosomal, terpene	bacillicn CER074	Bacillus mycoides

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.63	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001534.3	0.44	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001535.3	0.44	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001929.2	0.43	ribosomal	WGK	Streptococcus ferus
BGC0000571.3	0.41	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002674.2	0.41	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001639.3	0.41	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000543.5	0.40	ribosomal	pep5	Staphylococcus epidermidis
BGC0002701.2	0.39	ribosomal	paenithipeptin	Paenibacillus thiaminolyticus
BGC0001863.4	0.39	ribosomal, terpene	bacillicn CER074	Bacillus mycoides

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.58 out of 20.97

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.70 out of 28.19

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 19.49 out of 20.01

Confidence: strong

Additional weak hits (4):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.23 out of 26.85

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.85 out of 31.73

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.51 out of 30.98

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.52 out of 30.11

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
CcpA	Catabolite control protein A
ZuR variant 1	Zinc-responsive repressor

NZ_MTJS01000005.1 - Region 1 - RaS-RiPP

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Location: 121 - 26,502 nt. (total: 26,382 nt) Show pHMM detection rules used

RaS-RiPP: (PF04055 and TIGR01716)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

BW154_RS11895: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001209.3	0.62	ribosomal	streptide	Streptococcus thermophilus LMD-9
BGC0001929.2	0.48	ribosomal	WGK	Streptococcus ferus
BGC0000779.3	0.38	saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0000938.5	0.38	other (aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0002287.2	0.37	NRPS	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans
BGC0000806.5	0.29	saccharide	phosphonoglycans	Glycomyces sp. NRRL B-16210
BGC0000982.5	0.28	NRPS, PKS	cystothiazole A	Cystobacter fuscus
BGC0001055.5	0.28	NRPS, PKS	yersiniabactin	Escherichia coli
BGC0000780.3	0.24	saccharide	O&K-antigen	Vibrio parahaemolyticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001209.3	0.62	ribosomal	streptide	Streptococcus thermophilus LMD-9
BGC0001929.2	0.48	ribosomal	WGK	Streptococcus ferus
BGC0000779.3	0.38	saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0000938.5	0.38	other (aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0002287.2	0.37	NRPS	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans
BGC0000806.5	0.29	saccharide	phosphonoglycans	Glycomyces sp. NRRL B-16210
BGC0000982.5	0.28	NRPS, PKS	cystothiazole A	Cystobacter fuscus
BGC0001055.5	0.28	NRPS, PKS	yersiniabactin	Escherichia coli
BGC0000780.3	0.24	saccharide	O&K-antigen	Vibrio parahaemolyticus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.74 out of 26.06

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.97 out of 26.06

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.11 out of 26.06

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.02 out of 23.79

Confidence: medium

Additional weak hits (2):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.90 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.19 out of 28.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes

NZ_MTJS01000002.1 - Region 1 - T3PKS

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Location: 442,688 - 483,842 nt. (total: 41,155 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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NRPS/PKS domains

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase reductase

BW154_RS05070: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

BW154_RS05155: dehydrogenase

smcogs: SMCOG1181: dehydrogenase

Transferases: acetyltransferase glycosyltransferase

BW154_RS04980: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

BW154_RS05065: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

Ligases: synthase

BW154_RS05060: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.51	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.3	0.49	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000764.3	0.41	saccharide	exopolysaccharide	Lactococcus lactis
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0001080.5	0.37	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000286.3	0.36	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000934.4	0.36	other (phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0001076.5	0.35	other (nucleoside)	liposidomycin B, liposidomycin A, liposidomycin C, liposidomycin Z, liposidomycin H, liposidomycin G, liposidomycin L, liposidomycin M, liposidomycin K, liposidomycin N	Streptomyces sp. SN-1061M
BGC0000872.5	0.35	other (other)	A-90289 A, A-90289 B	Streptomyces sp. SANK 60405
BGC0001078.5	0.35	PKS, terpene	furaquinocin B	Streptomyces sp. KO-3988

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.51	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.3	0.49	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000764.3	0.41	saccharide	exopolysaccharide	Lactococcus lactis
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0001080.5	0.37	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000286.3	0.36	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000934.4	0.36	other (phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0001076.5	0.35	other (nucleoside)	liposidomycin B, liposidomycin A, liposidomycin C, liposidomycin Z, liposidomycin H, liposidomycin G, liposidomycin L, liposidomycin M, liposidomycin K, liposidomycin N	Streptomyces sp. SN-1061M
BGC0000872.5	0.35	other (other)	A-90289 A, A-90289 B	Streptomyces sp. SANK 60405
BGC0001078.5	0.35	PKS, terpene	furaquinocin B	Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.83 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.00 out of 27.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.76 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.41 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.26 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.96 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.67 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.92 out of 27.78

Confidence: medium

Additional weak hits (5):

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.17 out of 20.47

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.92 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.42 out of 31.73

Confidence: weak

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.78 out of 18.46

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes

NZ_MTJS01000002.1 - Region 2 - terpene-precursor

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Location: 1,237,049 - 1,257,906 nt. (total: 20,858 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

BW154_RS08655: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001756.3	0.29	terpene	retigeranin, arathanatriene	Arabidopsis thaliana
BGC0001605.3	0.28	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001227.3	0.27	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000633.3	0.27	terpene	carotenoid	Streptomyces avermitilis
BGC0000648.3	0.27	terpene	carotenoid	Myxococcus xanthus
BGC0001529.5	0.27	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001456.3	0.27	terpene	isorenieratene	Streptomyces argillaceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001756.3	0.29	terpene	retigeranin, arathanatriene	Arabidopsis thaliana
BGC0001605.3	0.28	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001227.3	0.27	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000633.3	0.27	terpene	carotenoid	Streptomyces avermitilis
BGC0000648.3	0.27	terpene	carotenoid	Myxococcus xanthus
BGC0001529.5	0.27	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001456.3	0.27	terpene	isorenieratene	Streptomyces argillaceus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

BW154_RS08655: PT_FPPS_like

Domain 1 (25 - 281): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.27 out of 26.06

Confidence: strong

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.74 out of 28.14

Confidence: medium

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 30.52 out of 30.97

Confidence: strong

Additional weak hits (3):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 19.86 out of 30.22

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.16 out of 27.55

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CopR	Copper-responsive regulator
MogR	Repressor of flagellar motility genes
PerR	Peroxide regulator

NZ_MTJS01000002.1 - Region 3 - lanthipeptide-class-i

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Location: 1,500,829 - 1,526,860 nt. (total: 26,032 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

BW154_RS09825: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase

BW154_RS09790: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

BW154_RS09835: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

BW154_RS09845: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Ligases: synthase

BW154_RS09885: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000535.4	0.96	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000538.3	0.92	ribosomal	nisin Z	Lactococcus lactis
BGC0000536.3	0.86	ribosomal	nisin Q	Lactococcus lactis
BGC0001789.3	0.78	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.76	ribosomal	nisin U	Streptococcus uberis
BGC0000549.3	0.68	ribosomal	salivaricin D	Streptococcus salivarius
BGC0000542.3	0.59	ribosomal	paenicidin B	Paenibacillus terrae
BGC0002323.2	0.58	ribosomal	nisin J	Staphylococcus capitis
BGC0000541.5	0.56	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000506.4	0.56	ribosomal	entianin	Bacillus subtilis subsp. spizizenii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000535.4	0.96	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000538.3	0.92	ribosomal	nisin Z	Lactococcus lactis
BGC0000536.3	0.86	ribosomal	nisin Q	Lactococcus lactis
BGC0001789.3	0.78	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.76	ribosomal	nisin U	Streptococcus uberis
BGC0000549.3	0.68	ribosomal	salivaricin D	Streptococcus salivarius
BGC0000542.3	0.59	ribosomal	paenicidin B	Paenibacillus terrae
BGC0002323.2	0.58	ribosomal	nisin J	Staphylococcus capitis
BGC0000541.5	0.56	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000506.4	0.56	ribosomal	entianin	Bacillus subtilis subsp. spizizenii

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for BW154_RS09845

BW154_RS09850

Leader:

MSTKDFNLDLVSVSKKDSGASPR

Core:

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

Core with dehydrations:

IDhbDhaIDhaLCysDhbPGCysKDhbGALMGCysNMKDhbADhbCysNCysDhaIHVDhaK

antiSMASH-DB 4.0 matches for BW154_RS09850

100.0%

NC_013656.1and 18 others:

NC_020450.1 Lanthipeptides: LILO_RS03015_lanthipeptideNZ_CP009472.1 Lanthipeptides: LG36_RS03420_lanthipeptideNZ_CP010050.1 Lanthipeptides: QI18_RS03300_lanthipeptideNZ_CP015903.1 Lanthipeptides: LLUC08_RS03255_lanthipeptideNZ_CP024954.1 Lanthipeptides: CV702_RS02990_lanthipeptideNZ_CP066300.1 Lanthipeptides: LacL0098_RS03205_lanthipeptideNZ_CP098790.1 Lanthipeptides: M5C73_RS03405_lanthipeptideNZ_JAALEQ010000006.1 Lanthipeptides: HFD15_RS10120_lanthipeptideNZ_JAJONJ010000005.1 Lanthipeptides: LSG16_RS07195_lanthipeptideNZ_JAQDWM010000007.1 Lanthipeptides: PGU01_RS08180_lanthipeptideNZ_JAQDXV010000018.1 Lanthipeptides: PGT80_RS11850_lanthipeptideNZ_JAQEIZ010000019.1 Lanthipeptides: PGX18_RS12025_lanthipeptideNZ_JAQEOU010000022.1 Lanthipeptides: PGV42_RS12330_lanthipeptideNZ_JAQEOV010000015.1 Lanthipeptides: PGW09_RS10765_lanthipeptideNZ_MTJP01000006.1 Lanthipeptides: BW151_RS03795_lanthipeptideNZ_MTJR01000005.1 Lanthipeptides: BW153_RS02980_lanthipeptideNZ_MTJS01000002.1 Lanthipeptides: BW154_RS09850_lanthipeptideNZ_RAGL01000022.1 Lanthipeptides: D6108_RS11395_lanthipeptide

Lanthipeptides: LLKF_RS13210_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

34

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

34

97.1%

NZ_CP065984.1and 2 others:

NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptideNZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide

Lanthipeptides: I6I21_RS02785_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

34

ITSISLCTPGCKTGALMGCNMKTATC+CSIHVSK

1

ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK

34

97.1%

NZ_JAQDYA010000007.1and 1 other:

NZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptide

Lanthipeptides: PGT72_RS09560_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

34

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVS+

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

with 123 more sequence matches

Only the first 10 are displayed here.

85.3%

NZ_FBTD01000003.1:

Lanthipeptides: PB1E_RS03075_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

34

ITS+SLCTPGCKTGALMGCNMKTA+C C +HVSK

1

ITSVSLCTPGCKTGALMGCNMKTASCGCHVHVSK

34

82.4%

NZ_JADNFO010000025.1:

Lanthipeptides: I2C89_RS09745_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

34

ITS SLCTPGCKTG LM C++KTATCNCSI VSK

1

ITSYSLCTPGCKTGVLMACHLKTATCNCSIIVSK

34

79.4%

NZ_CP090412.1and 3 others:

NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide

Lanthipeptides: LZF92_RS09890_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

34

ITS SLCTPGCKTGALMGC MKTA+C C +H+SK

1

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

34

77.1%

NZ_FNDP01000013.1:

Lanthipeptides: BLP54_RS11230_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHV

32

ITS SLCTPGC TG LMGCN KTATCNCS+HV

3

ITSKSLCTPGCVTGVLMGCNNKTATCNCSVHV

34

70.6%

NC_022237.1and 1 other:

NZ_JUZI01000019.1 Lanthipeptides: ADI02_RS09325_lanthipeptide

Lanthipeptides: SII_RS05025_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

34

+TS+ +CTPGC TGALMGCN++TATCNC +H+SK

1

VTSVFMCTPGCVTGALMGCNLQTATCNCHVHISK

34

68.6%

NZ_CP013655.1and 2 others:

NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptideNZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide

Lanthipeptides: ATZ35_RS03640_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

34

ITS SLCTPGC TG LMGC +KT TCNCS+ + K

1

ITSKSLCTPGCVTGVLMGCALKTITCNCSVGIGK

34

68.6%

NZ_FNDP01000013.1and 1 other:

NZ_FNDP01000013.1 Lanthipeptides: BLP54_RS11225_lanthipeptide

Lanthipeptides: BLP54_RS11220_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHV

32

ITS SLCTPGC TG LMGC +ATCNCS+HV

3

ITSKSLCTPGCVTGLLMGCAGSSATCNCSVHV

34

67.6%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSI

30

ITS SLCTPGCKTGALM C +KTATC C

1

ITSKSLCTPGCKTGALMTCPIKTATCGCHF

30

67.6%

NZ_LR793265.1:

Lanthipeptides: HV392_RS09830_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

34

ITS SLCTPGC TG LMGC ++A CN +HVSK

1

ITSYSLCTPGCITGVLMGCQFQSAGCNVHVHVSK

34

64.7%

NZ_CP009913.1and 1 other:

NZ_CP009913.1 Lanthipeptides: SSAL8618_RS00810_lanthipeptide

Lanthipeptides: SSAL8618_RS00815_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

34

ITS SLCTPGC TG LMGC++++ CN +HVSK

1

ITSYSLCTPGCITGVLMGCHIQSIGCNVHVHVSK

34

MIBiG 4.0 matches for BW154_RS09850

97.1%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

34

ITSISLCTPGCKTGALMGCNMKTATC+CSIHVSK

1

ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK

34

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 28.19 out of 30.97

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.78 out of 18.16

Confidence: strong

Additional weak hits (3):

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.72 out of 18.46

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.64 out of 35.63

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.28 out of 29.72

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

BW154_RS09850 - Class I

Cleavage pHMM score: 26.70

RODEO score: 27

Monoisotopic mass: 3310.6 Da

Molecular weight: 3313.0 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3331.0 Da N = 1; 3349.0 Da N = 2; 3367.0 Da N = 3; 3385.1 Da N = 4

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 141 - 229; Score: 25.7

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
CopR	Copper-responsive regulator
MogR	Repressor of flagellar motility genes

NZ_MTJS01000002.1 - Region 4 - RiPP-like,betalactone

Download region GenBank file

Download region SVG

Location: 1,527,929 - 1,564,756 nt. (total: 36,828 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

BW154_RS09935: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: ligase

BW154_RS09970: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002447.3	0.19	ribosomal	cerecyclin	Bacillus cereus
BGC0002116.3	0.13	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000501.3	0.12	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0001579.4	0.12	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000904.5	0.12	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0000916.5	0.12	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0002699.2	0.11	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0001391.3	0.11	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0002092.3	0.10	NRPS	stechlisin B2, stechlisin C3, stechlisin D3, tensin, stechlisin E2, stechlisin F	Pseudomonas sp.
BGC0000412.5	0.10	NRPS	pyochelin	Pseudomonas aeruginosa PAO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000904.5	0.43	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0002116.3	0.41	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000501.3	0.40	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0002699.2	0.40	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0001391.3	0.40	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0001579.4	0.39	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0002447.3	0.39	ribosomal	cerecyclin	Bacillus cereus
BGC0002681.3	0.37	other (other)	rhizoferrin	Francisella tularensis subsp. tularensis SCHU S4
BGC0000543.5	0.37	ribosomal	pep5	Staphylococcus epidermidis
BGC0001660.3	0.37	ribosomal	mathermycin	Marinactinospora thermotolerans

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 26.19 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.98 out of 27.78

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.05 out of 20.97

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.54 out of 26.33

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.34 out of 28.19

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.63 out of 35.63

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.73 out of 32.93

Confidence: medium

Additional weak hits (5):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.59 out of 29.25

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.17 out of 39.62

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 25.19 out of 30.97

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.63 out of 31.73

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.94 out of 27.18

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
NrtR	NAD synthesis repressor
ZuR variant 1	Zinc-responsive repressor