LOCUS       NZ_MTJS01000002        26032 bp    DNA     linear   CON 23-AUG-2024
DEFINITION  Lactococcus lactis strain 537 contig_8, whole genome shotgun
            sequence.
ACCESSION   NZ_MTJS01000002
VERSION     NZ_MTJS01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Lactococcus lactis
  ORGANISM  Lactococcus lactis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Lactococcus.
REFERENCE   1  (bases 1 to 1672417)
  AUTHORS   Ho,V., Lo,R., Bansal,N. and Turner,M.S.
  TITLE     Characterization of Lactococcus lactis isolates from herbs, fruits
            and vegetables for use as biopreservatives against Listeria
            monocytogenes in cheese
  JOURNAL   Food Control (2017) In press
REFERENCE   2  (bases 1 to 1672417)
  AUTHORS   Lo,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2017) School of Agriculture and Food Sciences, The
            University of Queensland, Hartley Teakle Bldg (No. 83), Slip Rd, St
            Lucia, Brisbane, QLD 4072, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. Jun 2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1036.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002563475.1-RS_2024_08_23
            Annotation Date                   :: 08/23/2024 15:27:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,579
            CDSs (total)                      :: 2,519
            Genes (coding)                    :: 2,482
            CDSs (with protein)               :: 2,482
            Genes (RNA)                       :: 60
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 51
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 37
            CDSs (without protein)            :: 37
            Pseudo Genes (ambiguous residues) :: 0 of 37
            Pseudo Genes (frameshifted)       :: 14 of 37
            Pseudo Genes (incomplete)         :: 23 of 37
            Pseudo Genes (internal stop)      :: 8 of 37
            Pseudo Genes (multiple problems)  :: 7 of 37
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:09:48
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1500828
            Orig. end                         :: 1526860
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MTJS01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26032
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26032
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26032
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16032](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16032)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(67..1122)
                     /locus_tag="BW154_RS09790"
                     /old_locus_tag="BW154_09805"
     CDS             complement(67..1122)
                     /EC_number="2.7.7.65"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012897362.1"
                     /locus_tag="BW154_RS09790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09805"
                     /product="GGDEF domain-containing protein"
                     /protein_id="WP_058205260.1"
                     /transl_table=11
                     /translation="MFISILANMSILLVSLYGYLSYYVNYNKFHSFLKDKGTFFNSIFV
                     TIVGIFLLYFAIEIGGARYDLRFLLLAFTVKYFGNKVTITSTLLLMVLRLFWGIDNHTP
                     IAICYSVLLVFTLPMLKYIVSKINSDIIQLLILNYYCLLIGNFLNAIIIKNPLRDINIY
                     LHLYVISTILVFVLYYMINDIKKMQKKATHDYLTKMKNRSEFQAKLEVLQKKKKFFSLA
                     ILDIDYFKVFNDSFNHLVGDLVLLEVSKVLLSFEGNKINCYRIGGEEFSLVFEEINFVE
                     VENKLEKIRLAVQKIDIDEMLLDGEVRGITVSIGVSHIKTFSNIENYISSADDALYKAK
                     ENGRNQLVVGK"
     gene            complement(1167..1877)
                     /locus_tag="BW154_RS09795"
                     /old_locus_tag="BW154_09810"
     CDS             complement(1167..1877)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012897361.1"
                     /locus_tag="BW154_RS09795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09810"
                     /product="EAL domain-containing protein"
                     /protein_id="WP_058205261.1"
                     /transl_table=11
                     /translation="MQDYNDLFYLIYQPIVNIKNNGTLEILEYEVLLRSQDKRRFPNKE
                     FNEILFSPEKHQMFMKWYFEKLNDILVRNKNINLAINIHPLQWKEPIIFDFFYKLKEFS
                     NRIKIELTEHRNFLEFDLDMVFKSRYAELVMLGYNFVIDDVGNGTNDIDFVIKHIEQVS
                     SIKFSILPFRDIKKETLILFIEAWFHMAKEFDKEFVVEGIECKIFSSCLLNMGIRLQQG
                     FLFGEGKSHVASSK"
     misc_feature    complement(2232..2245)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: weak, score: 15.72"
                     /tool="antismash"
     misc_feature    2298..2311
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.62"
                     /tool="antismash"
     gene            complement(2989..3633)
                     /locus_tag="BW154_RS09800"
                     /old_locus_tag="BW154_09815"
     CDS             complement(2989..3633)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570415.1"
                     /locus_tag="BW154_RS09800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09815"
                     /product="transporter"
                     /protein_id="WP_017864242.1"
                     /transl_table=11
                     /translation="MIRSECLKLKNSLGFYLVFLFTLLELLTVPIYLAFGRSHVSMTDL
                     SLMIFLFFPLLVTILSILIFEQESLANHFQEINVNKKSSRIWLSKLIVVDFLLFFPSAM
                     IWIITGVSQAVGQQGMMIATASWLMAIFLNHFHLLLTFIINRGGSMIIAIIEILLIIFA
                     SNKVLLAAYWCPIALPVNFMITGRCAYLIAAVGWIVLSTIILVALSKKKIR"
     gene            complement(3620..4348)
                     /locus_tag="BW154_RS09805"
                     /old_locus_tag="BW154_09820"
     CDS             complement(3620..4348)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864241.1"
                     /locus_tag="BW154_RS09805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09820"
                     /product="lantibiotic ABC transporter permease"
                     /protein_id="WP_017864241.1"
                     /transl_table=11
                     /translation="MKRIIASEAIKLKKSGTLRLVLIIPFVTLFIAFLMGGIQIFSVFS
                     IYWWEAGFLFLLMSLLFLYDKKSEEQAGNFQNVKWKKLSWKIHLAKMLLIWLRGILASI
                     VLIILLYLVAFVFQGIVVVDFMKVSVALIAILLAASWNLPFIYLIFKWINTYVLLAANT
                     LICLIVAPFVAQTPVWFLLPYTYHYKVTESLLNIKPSGDLLTGKINFSIWEVLLPVGLS
                     IVVTIGVSYLLKGVIEHDKK"
     gene            complement(4350..5027)
                     /locus_tag="BW154_RS09810"
                     /old_locus_tag="BW154_09825"
     CDS             complement(4350..5027)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012897845.1"
                     /locus_tag="BW154_RS09810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09825"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_015425986.1"
                     /transl_table=11
                     /translation="MQVKIQNLSKTYKEKQVLQDISFDIKSGTVCGLLGVNGAGKSTLM
                     KILFGLISADTGKIFFDGQEKTNNQLGALIEAPAIYMNLSAFDNLKTKALLFGISDKRI
                     HETLEVIGLAETGKKRAGKFSLGMKQRLGIGMAILTEPQFLILDEPTNGLDPDGIAELL
                     NLILKLKAKGVTILISSHQLHEISKVASQIIILNKGKIRYNHANNKEDDIEQLFFKIVH
                     GGM"
     gene            complement(5126..6469)
                     /locus_tag="BW154_RS09815"
                     /old_locus_tag="BW154_09830"
     CDS             complement(5126..6469)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864239.1"
                     /locus_tag="BW154_RS09815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09830"
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="WP_098394055.1"
                     /transl_table=11
                     /translation="MGKKYSMRRRIWQAVIEIIIGTCLLILLLLGLTFFLRQIGQISGS
                     ETIRLSLDSDNLTISDIERDMKHYPYDYIIFDNDTSKILGGHYVKSDVPSFVASKQSSH
                     NITEGEITYTYSSNKHFSVVLRQNSMPEFTNHTLRSISYNQFTYLFFFLGEIILIIFSV
                     YHLIREFSKNFQAVQKIALKMGEITTFPEQEESKIIEFDQVLNNLYSKSKELAFLIEAE
                     RHEKHDLSFQVAALSHDVKTPLTVLKGNIELLEMTVVNEQQADFIESMKNSLTVFDKYF
                     NTMISYTKLLNDENDYKARISLEDFLIDLSVELEELSTTYQVDYQLVKKTDLTTFYGNT
                     LALSRALINIFVNACQYAKEGEKIVSLSIYDDEKHLYFEIWNNGHPFSEQAKKNAGKLF
                     FTEDTGRSGKHYGIGLSFAQGVALKHQGNLILSNPQKGGAEVILKIKK"
     gene            complement(6462..7148)
                     /locus_tag="BW154_RS09820"
                     /old_locus_tag="BW154_09835"
     CDS             complement(6462..7148)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014734918.1"
                     /locus_tag="BW154_RS09820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09835"
                     /product="response regulator transcription factor"
                     /protein_id="WP_014734918.1"
                     /transl_table=11
                     /translation="MYKILIVDDDQEILKLMKTALEMRNYEVATHQNISLPLDITDFQG
                     FDLILLDIMMSNIEGTEICKRIRREISTPIIFVSAKDTEEDIINGLGIGGDDYITKPFS
                     LKQLVAKVEANIKREERNKHAVHVFSEIRRDLGPITFYLEERRVCVNGQTIPLTCREYD
                     ILELLSQRTSKVYTREDIYDDVYDEYSNALFRSISEYIYQIRSKFAPYDINPIKTVRGL
                     GYQWHG"
     gene            complement(7217..9265)
                     /locus_tag="BW154_RS09825"
                     /old_locus_tag="BW154_09840"
     CDS             complement(7217..9265)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570410.1"
                     /locus_tag="BW154_RS09825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09840"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_098394056.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 6.6e-47, bitscore:
                     156.8, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKILGFLFIVCSLGLSATVHGETTNSQQLLSNNINTELINHNSN
                     AILSSTEGSTTDSINLGEQSPAVKSTTRTELDVTGAAKTLLQTSAVQKEMKVSLQETQV
                     SSEFSKRDSVTNKEAVPVSKDELLEQSEVVVSTSSIQKNKILDNKKNRANFVTSSQLIK
                     EKPSNSKDASGVIDNSASPLSYRKAKEVVSLRQPLKNQKVEAQPLLISNSSEKKASVYT
                     NSHDFWDYQWDMKYVTNNGESYALYQPSKKISVGIIDSGIMEEHPDLSNSLGNYFKNLV
                     PKGGFDNEEPDETGNPSDIVDKMGHGTEVAGQITANGNILGVAPGITVNIYRVFGENLS
                     KSEWVARAIRRAADDGNKVINISAGQYLMISGSYDDGTNDYQEYLNYKSAINYATAKGS
                     IVVAALGNDSLNIQDNQTMINFLKRFRSIKVPGKVVDAPSVFEDVIAVGGIDGYGNISD
                     FSNIGADAIYAPAGTTANFKKYGQDKFVSQGYYLKDWLFTTTNTGWYQYVYGNSFAVPK
                     VSGALALVVDKYGIKNPNQLKRFLLMNSPEVNGNRVLNIVDLLNGKNKAFSLDTDKGQD
                     DAINHKSMENLKESRDTMKQEQDKEIQRNTNNNFSIKNDFHNISKEVISVDYNINQKMA
                     NNRNSRGAVSVRSQEILPVTGDGEDFLPALGIVCISILGILKRKTKN"
     gene            complement(9267..10004)
                     /locus_tag="BW154_RS09830"
                     /old_locus_tag="BW154_09845"
     CDS             complement(9267..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570409.1"
                     /locus_tag="BW154_RS09830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09845"
                     /product="NisI/SpaI family lantibiotic immunity
                     lipoprotein"
                     /protein_id="WP_058205263.1"
                     /transl_table=11
                     /translation="MRKYLILIVALIGITGLSGCYQTSQKKVRFDEGSYTNFIFDNKSY
                     FVTDKEIPQENVNNSKVKFYNLLIVDMKSEKLLSSSNKNSVTLVLNNIYEASDKSLCMG
                     INDRYYKILPESDKGAVKALRLQNFDVTSDISDDNFVIGKNDSRKIDYMGNIYSISDTT
                     VSDEELGEYQDFLAEVRVFDSVSGKSIPRSEWGRIDKDGSNSKQSRTEWDYGEIHSIRG
                     KSLTEAFAVEINDDFKLATKVGN"
     gene            complement(10001..11248)
                     /locus_tag="BW154_RS09835"
                     /old_locus_tag="BW154_09850"
     CDS             complement(10001..11248)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570408.1"
                     /locus_tag="BW154_RS09835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09850"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_235585319.1"
                     /sec_met_domain="LANC_like (E-value: 7.1e-73, bitscore:
                     241.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNKKNIKRNVEKIIAQWDERTRKNKENFDFGELTLSTGLPGIIL
                     MLAELKNKDNSKIYQKKIDNYIEYIVSKLSTYGLLTGSLYSGAAGIALSILHLREDDEK
                     YKNLLDSLNRYIEYFVIEKIEGFNLENITPPDYDVIEGLSGILSYLLLINDEQYDDLKI
                     LIINFLSNLTKENKGLISLYIKSENQMSQSESEMYPLGCLNMGLAHGLAGAGCILAYAH
                     IKGYSNEASLSALQKIIFIYEKFELERKNQFLWKDGLVADELKKEKVIREASFIRDAWC
                     YGGPGISLLYLYGGLALDNDYFVDKAEKILESAMQRKLGIDSYMICHGYSGLIEICSLF
                     KRLLNTKKFDSYIEEFNVNSEQILEEYGDESGTGFLEGISGCILVLSKFEYSINFTYWR
                     QALLLFDDFLKGGKRK"
     gene            complement(11238..13040)
                     /locus_tag="BW154_RS09840"
                     /old_locus_tag="BW154_09855"
     CDS             complement(11238..13040)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015425980.1"
                     /locus_tag="BW154_RS09840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09855"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_058205264.1"
                     /transl_table=11
                     /translation="MDEVKEFTSKQFFNTLLTLPSTLKLIFQLEKRYAIYLIVLNAITA
                     FVPLASLFIYQDLINSVLGSGRHLIYIIIIYFIVQVITTVLGQLESYVSGKFDMRLSYS
                     INMRLMRTTSSLELSDYEQADMYNIIEKVTQDSTYKPFQLFNAIIVVLSSFISLLSSLF
                     FIGTWNIGVAILLLIVPVLSLVLFLRVGQLEFLIQWQRASSERETWYIVYLLTHDFSFK
                     EIKLNNISNYFIHKFGKLKKGFINQDLAIARKKTYFNIFLDFILNLINILTIFAMILSV
                     RAGKLLIGNLVSLIQAISKINTYSQTMIQNIYIIYNTSLFMEQLFEFLKRESVVHKKIE
                     DTEICNQDIGTVKVINLSYVYPNSNAFALKNINLSFEKGELAAIVGKNGSGKSTLVKII
                     SGLYQPTMGIIQYDKMRSSLMPEEFYQKNISVLFQDFVKYELTIRENIGLSDLSSQWED
                     EKIIKVLDNLGLDFLKTNNQYVLDTQLGNWFQEGRQLSGGQWQKIALARTFFKKASIYI
                     LDEPSAALDPVAEKEIFDYFVALSENNISIFISHSLNAARKANKIVVMKDGQVEDVGSH
                     DVLLRRCQYYQELYYSEQYEDNDE"
     misc_feature    13017..13032
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     gene            complement(13051..16032)
                     /locus_tag="BW154_RS09845"
                     /old_locus_tag="BW154_09860"
     CDS             complement(13051..16032)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864234.1"
                     /locus_tag="BW154_RS09845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09860"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_098394057.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2e-84, bitscore:
                     280.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.2e-06,
                     bitscore: 25.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.8e-16, bitscore:
                     55.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKSSFKAQPFLVRNTILSPNDKRSFTEYTQVIETISKNKVFLEQ
                     LLLANPKLYNVMQKYNAGLLKKKRVKKLFESIYKYYKRSYLRSTPFGLFSETSIGVFSK
                     SSQYKLMGKTTKGIRLDTQWLIRLVHKMEVDFSKKLSFTRNNANYKFGDRVFQVYTINS
                     SELEEVNIKYTNVYQIISEFCENDYQKYEDICETVTLCYGDEYRELSGQYLGSLIVNHY
                     LISNLQKDLLSDFSWDTFLTKVEAIDEDKKYIIPLKKVQKFIQEYSEIEIGEGIEKLKE
                     IYQEMSQILENDNYIQIDLISDSEINFDVKQKQQLEHLAEFLGNTTKSVRRTYLDDYKD
                     KFIEKYGVDQEVQITELFDSTFGIGAPYNYNHPRNDFYESEPSTLYYSEEEREKYLSMY
                     VEAIKNHNVINLDDLESHYQKMDLEKKSELQGLELFLNLAKEYEKDIFILGDIVGNNNL
                     GGASGRFSALSPELTSYHRTIVDSVERENENKEITSCEIVFLPENIRHANVMHTSIMRR
                     KVLPFFTSTSHNEVQLTNIYIGIDEKEKFYARDISTQEVLKFYITSMYNKTLFSNELRF
                     LYEISLDDKFGNLPWELIYRDFDYIPRLVFDEIVISPAKWKIWGRNVNNKMTIRELIQS
                     KEIPKEFYIVNGDNKVYLSQENPLDMEILESAIKKSSKRKDFIELQEYFEDENIINKGQ
                     KGRVADVVVPFIRTRALGNEGRAFIREKRVSVERREKLPFNEWLYLKLYISINRQNEFL
                     LSYLPDIQKIVANLGGNLFFLRYTDPKPHIRLRIKCSDLFLAYGSILEILKRSQKNRIM
                     STFDISIYDQEVERYGGFDTLELSEAIFCADSKIIPNLLTLIKDTNNDWKVDDVSILVN
                     YLYLKCFFQNDNKKILNFLNLVSPKKVKENVNEKIEHYLKLLKVDNLGDQIFYDKNFKE
                     LKHAIKNLFLKMIAQDFELQKVYSIIDSIIHVHNNRLIGIERDKEKLIYYTLQRLFVSE
                     EYMK"
     aSDomain        complement(15346..15609)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BW154_RS09845_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.10E-08"
                     /identifier="RREFam001.1"
                     /label="BW154_RS09845"
                     /locus_tag="BW154_RS09845"
                     /protein_end="229"
                     /protein_start="141"
                     /score="25.7"
                     /tool="antismash"
                     /translation="FTRNNANYKFGDRVFQVYTINSSELEEVNIKYTNVYQIISEFCEN
                     DYQKYEDICETVTLCYGDEYRELSGQYLGSLIVNHYLISNLQK"
     gene            complement(16140..16313)
                     /locus_tag="BW154_RS09850"
                     /old_locus_tag="BW154_09865"
     CDS             complement(16140..16313)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570405.1"
                     /locus_tag="BW154_RS09850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09865"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_015425978.1"
                     /sec_met_domain="TIGR03731 (E-value: 2e-22, bitscore: 75.5,
                     seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 9.4e-06, bitscore:
                     21.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTKDFNLDLVSVSKKDSGASPRITSISLCTPGCKTGALMGCNMK
                     TATCNCSIHVSK"
     CDS_motif       complement(16245..16313)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSTKDFNLDLVSVSKKDSGASPR"
                     /locus_tag="BW154_RS09850_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16140..16244)
                     /prepeptide="core"
                     /locus_tag="BW154_RS09850_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="26.70"
                     /molecular_weight="3313.0"
                     /monoisotopic_mass="3310.6"
                     /core_sequence="ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSTKDFNLDLVSVSKKDSGASPR"
                     /leader_location="[16244:16313](-)"
                     /alternative_weights="3331.0"
                     /alternative_weights="3349.0"
                     /alternative_weights="3367.0"
                     /alternative_weights="3385.1"
     misc_feature    16854..16874
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 24.64"
                     /tool="antismash"
     misc_feature    complement(17365..17381)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 20.28"
                     /tool="antismash"
     misc_feature    17615..17630
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: medium, score: 28.19"
                     /tool="antismash"
     gene            17643..17915
                     /locus_tag="BW154_RS09855"
                     /old_locus_tag="BW154_09870"
     CDS             17643..17915
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864233.1"
                     /locus_tag="BW154_RS09855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09870"
                     /product="(4Fe-4S)-binding protein"
                     /protein_id="WP_058205265.1"
                     /transl_table=11
                     /translation="MSNSKLFENDVTEEELLKKNYRKYHGGKMDIYYNVAICEHAGECV
                     RGNPLVFEVGRKPWIIPDNGDIASNQSVINRCPSGALKYLAKEKN"
     gene            17915..18187
                     /locus_tag="BW154_RS09860"
                     /old_locus_tag="BW154_09875"
     CDS             17915..18187
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011675645.1"
                     /locus_tag="BW154_RS09860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09875"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_021214922.1"
                     /transl_table=11
                     /translation="MNIIERENLFELLSDKGEVIGEMAYMPMNNSIIITHTGVSLDYRG
                     QGLAEKLVLAGIQKARREQLKLGATCPYAVKYFREHKEELTDVLK"
     gene            18424..19794
                     /gene="brnQ"
                     /locus_tag="BW154_RS09865"
                     /old_locus_tag="BW154_09880"
     CDS             18424..19794
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015658 - branched-chain amino acid
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0015803 - branched-chain amino acid
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="brnQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003129615.1"
                     /locus_tag="BW154_RS09865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09880"
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="WP_058203230.1"
                     /transl_table=11
                     /translation="MEEKLAGKDYLFIGSMLFGLFFGAGNLIFPIHMGQEAGAAISQAN
                     FGFLITAVGFPFLGIIALGISQSNGVFELASRVNRIYAYIFTILLYLVIGPFFALPRLA
                     TTSFEIGISPFLSHELQAPLLALFSILFFGTAWFLSRKPTKLLDYIGKFLNPLFLVLLG
                     IILVIAFTHPLGKVSQAEIGKAYQASPILTGFTQGYNTLDALAALAFGIIIITTIRQRG
                     VKNPKIIAKETIKAGLISVGLMAIIYTCLSYLGTMSLGQFAISENGGIALAQISNHYLG
                     NFGMIILALIVIIACLKTAVGLMSAFSETFAELFPKKEYRFYLLIVSILPCIFANIGLT
                     KIIELSVPVLMFLYPLAIILILLALLSPLFKHSRLVYQITTAFTLLAAIIDGLNALPAS
                     LHTITFISVIINFAKDFLPFFSLGMGWILPAVLGFIIGCLCQIAITVYKNKKSSTLS"
     gene            complement(19871..21325)
                     /locus_tag="BW154_RS09870"
                     /old_locus_tag="BW154_09885"
     CDS             complement(19871..21325)
                     /GO_function="GO:0005518 - collagen binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864230.1"
                     /locus_tag="BW154_RS09870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09885"
                     /product="LPXTG cell wall anchor domain-containing protein"
                     /protein_id="WP_098394058.1"
                     /transl_table=11
                     /translation="MKAKNKSFKLLMVLSLLMCLVGINLFKPSNVFAADYGNKFITGHE
                     LTDDLGNPKTDFGIYDDVQAHWDFDIPVGSVSQGDTMSVNVPDLLTLSKDITFEIKDEA
                     GNIIGTAVANHLTGVVTVTFSKLVENATSDIKGTLSVWVNWDEQKVEEDTRVVVDWKDG
                     GTTEVNIGPATGPDKDEVLYKWGWVDENDSTLIHWQVRINYAKENIQKAIYTDIIGGNQ
                     NLVSGSISVANVTYSSDGENYNVDSYYPQASILENGVNGFTVNLGDISNTIIIDYSTRA
                     TDGGLSQQYENRGELTGENIEKQVVEVHTPNNGGNGNASMKLSISGEKTWIDDNNARGL
                     RPSFISIELYRNGEKVDSRDVTAKENWKYSFTNLDKYDESGKLYDYDVKEVSVSNYTSQ
                     QEGYNFINTIIPVKEEAPEKTDQSITTPSSSSQVMSTSSSSMESETSEELPKTGDSPRD
                     FFKVLGILLLISGVLGMIYIKRKSKN"
     misc_feature    complement(21314..21323)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 16.78"
                     /tool="antismash"
     gene            complement(21352..22245)
                     /locus_tag="BW154_RS09875"
                     /old_locus_tag="BW154_09890"
     CDS             complement(21352..22245)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864229.1"
                     /locus_tag="BW154_RS09875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09890"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_038599660.1"
                     /transl_table=11
                     /translation="MKFSKKNIFLILMFGLIAILVFMSTRETKKYVQDGKKEQPDFAYE
                     SLLKDNDGIIVLCYHRVLKDTVVTNFAYSISHNSQLHEYNVFLQDFEQQMTFLKKNHIK
                     VLTSSELIEKLNKKEVIGKAVVITFDDIDKSLPENAYPIMKKLDLPFTQFIITGKVGQT
                     IDGSQMSTWKEIKKMNENPLVTSGLHTNDLHYQENFEPILSTNISKKVVQKDYQKSQKA
                     FDEKLDQKGKVFAYPYGAQNKDLEDYMLQDGIQGIFTLSPGVVTNETLYSNIPRLIVTK
                     DNWKTIKHWLLSEGTQ"
     gene            complement(22518..23738)
                     /locus_tag="BW154_RS09885"
                     /old_locus_tag="BW154_09900"
     CDS             complement(22518..23738)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864227.1"
                     /locus_tag="BW154_RS09885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09900"
                     /product="glycosyltransferase"
                     /protein_id="WP_038599654.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.2e-29,
                     bitscore: 99.1, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIISTMVDVYVVYYPIILSFIWASGAFLSRWKERDKKAIDETKEF
                     EKISIVISAYNEEETIEEVLLSLHNLNYPSLEIFIVDDKSSDRTLEKLYEVKKSFDDWE
                     TLTILEQKENKGKATALNVALQQVNSKYMLVIDADSYLSKDALSYLLAELTSSSDIGAV
                     TGRPIVRNRTTLLGKLQTLEYLSVIDAIKRAQSLFLGAIMTVSGVIVMYRVEALKEIGG
                     FNTEVMTEDIDVTWRLHRNQWKVKYVPKALSYILVPENLKSLLKQRRRWAVGGVEVLIS
                     NLSWVFKRGEFKHRFLLIEMICSHIWSWFFLIESYQYFLQMLLNQEFKVSGQIIVIFVL
                     ISFFVFFLGLNNDKGESRLSLTDKLIFPAYLVAYWFLNLISALSAELVVLTNRTNKGKW
                     ESPDRGV"
     gene            complement(23743..24774)
                     /locus_tag="BW154_RS09890"
                     /old_locus_tag="BW154_09905"
     CDS             complement(23743..24774)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003129606.1"
                     /locus_tag="BW154_RS09890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW154_09905"
                     /product="acyltransferase"
                     /protein_id="WP_038599650.1"
                     /transl_table=11
                     /translation="MKRNSSIDLMKSCAIFFVISVHFLLNSGFYDMTIHSTLGIFWIGI
                     RTILITCVPLFLVATGFLMNRKELNAQYVLGIVPVIISYIGISLLVWGVLSLVGKGSDF
                     STAINGIFDYSTDSYSWYVEMYLGLYLFIPLLNIIWNYKKEIKNYHLYIVFIASLLTFL
                     PSLLNSFGKVIPDYWQICYPVSYYFIGACLYTYQNEIKKISIGKLVTAFLSALTIFTLT
                     DTFASWNQEFQWLDHNDYFGYQTAIMTVLVIAILWRIPIPKWSVRLLKALSTATLTIYL
                     ISDLTDQFVYGFFKHEIPNLSQRVIAGPIIIPVAFTSAALLGIFVGKVLNFPFKRKKER
                     KEN"
ORIGIN
        1 atgattttcc aaagcttttc ctttactctt taaataaatt gactagattt aatagtaata
       61 aaaaaattac ttacctacca ctaattgatt tcttccattt tccttagctt tatataaagc
      121 gtcatccgca cttgaaatgt aattttcaat atttgagaat gtctttatat gggatactcc
      181 tatggaaaca gtaatacctc ttacttctcc atccaatagc atttcatcga tgtctatttt
      241 ttgaactgct aatctaattt tttctaattt attttcaacc tctacaaaat ttatttcttc
      301 aaagacgagt gaaaattctt cccctcctat acggtagcaa tttattttat ttccctcaaa
      361 agataataaa actttgctca cttctaataa tactaaatca ccaactaaat gattaaatga
      421 gtcattaaat actttaaaat aatcaatatc caaaatagct aaagaaaaaa attttttctt
      481 tttctgtaat acttctagtt tagcttggaa ttcacttcta tttttcattt ttgttaggta
      541 atcatgagta gccttcttct gcatcttttt tatatcgttt atcatataat aaaggacaaa
      601 taccaatatc gtacttatga catataaatg cagataaata tttatgtccc taagtggatt
      661 tttaataatt atagcattca aaaaattccc aattaataaa cagtagtaat tcaaaattaa
      721 gagttgaata atatcactat taattttact cacaatatat tttagcatgg gtaaggtaaa
      781 taccaatagt acactataac aaatagcaat aggtgtatga ttatctatgc cccaaaataa
      841 tcttaaaacc attaataata gagtgctcgt tatagtaact ttatttccaa aatatttaac
      901 agtaaatgct aataaaagaa atcttaaatc atatctagca ccaccaattt caattgcaaa
      961 gtacaataaa aaaatcccta caatagttac aaaaattgaa ttaaaaaaag ttcccttgtc
     1021 tttcaaaaaa gaatgaaact tgttataatt cacataatag cttaagtaac cataaagaga
     1081 aactaataaa atgctcatat ttgctaaaat actaataaac attcaacact ccctaaattt
     1141 ataaatacaa aattaaaaaa atctttttat ttacttgaag caacatgact tttaccttca
     1201 ccaaatagaa atccctgttg tagtcttatc cccatattta ataagcatga ggaaaatatt
     1261 ttacactcaa taccttcaac cacaaattcc ttatcaaatt ctttcgccat atgaaaccat
     1321 gcttcaataa ataatattaa agtttctttt tttatatctc gaaaaggcaa tatggaaaat
     1381 tttatactag aaacttgttc tatatgtttg atgacaaagt ctatatcatt tgttccattc
     1441 ccgacatcat caattacaaa attatatcca agcataacta attcagcata tcttgatttg
     1501 aataccatat caagatcaaa ttctaaaaaa tttctatgtt cagttaactc aatttttatt
     1561 ctatttgaaa actcttttaa cttataaaaa aaatcaaaaa ttataggttc cttccattgt
     1621 aagggatgaa tgtttatagc caaattaata tttttatttc taactaagat atcattaagt
     1681 ttttcaaaat accacttcat aaacatttgg tgtttttcag gtgaaaataa aatttcatta
     1741 aattccttat ttggaaaacg ccttttatcc tgagatcgaa gtagaacctc atattctaaa
     1801 atttctaatg ttccattatt tttaatattt actattggtt gataaataag ataaaataaa
     1861 tcattatagt cttgcatcta cacattctac tatatcttta cttttacatt gggatgaata
     1921 tttaagtaac ttctgctcat tattataatt gttattttca attaaaatat aaattgtaaa
     1981 attactttac aactataaaa atagatacta taactatgta ctttaaaagc ctttatctgt
     2041 attataccaa tttgtaaatt atttattttt tataatataa taaatttttg gtcaatttaa
     2101 atattttatt tattattagt ttatattttt ggcttctact aacttatatt tcaaaaaatt
     2161 cctataattt actatcttga ttaaaattta tttaacattt tatctttatg aatccataaa
     2221 aatattaaaa agcaaagtct ataccacaat gaaaactttt tgttaatatt ataattgtaa
     2281 aaatttttgc tggctatttt ttataataaa agatagagtt tacttttaag ctttctttcg
     2341 ctacattttt ccaatcttaa aaatatagga tataaaataa aatagtttgt atgctattga
     2401 ttgaaaaaac tagttgaata ataaatattt atgcctctaa gatttatatg taaatttgat
     2461 ttaatatttt caactacaaa aacctactgt aaatttacag taggcttatg ataaagtagt
     2521 tgctgtatag ttttgctttg gttcatttta ttattatcaa cgatacatct tttaattcta
     2581 ggttaaaatg cactttatat gtctatcaaa aataataaaa aatccaagta tttatacttg
     2641 gattttttat tgtttaattt tctcttttat atagaaactc atattcttca caaataactg
     2701 gcatatcagt ttaaaaatgt tatatgcttt aaagaatctc tcatgagctt gacaccaata
     2761 actccagaag aaaaagtgta agtcgatagg aaaccacttt ataaaaaatt actgagaaaa
     2821 gaaaactaac gacgaaaaca ttattcttag agtaagagct gtcacatatt gatagaaatt
     2881 ttattcaaac ttatgagtct aaaggtactt tgaataaatt actatagaca gaaataagag
     2941 ataaatagca aaaacatatt aggtcgaatt accataagaa aaaatacttt atctaatctt
     3001 ttttttagat aatgccacaa gaattattgt ggataaaaca atccacccta cggcagctat
     3061 cagataagca caccgcccag ttatcataaa attaacaggt aaagcaatag gacaccaata
     3121 agctgctaat aaaactttat tactggcaaa aataatgagt aatatttcaa taatcgcgat
     3181 aatcatgctc cctcctcgat tgattataaa ggtcaataaa agatgaaaat gattaagaaa
     3241 aattgccatc aaccagctag ctgttgcgat catcattcct tgttgcccta ctgcctgtga
     3301 aactcccgta attatccaga tcattgctga tggaaagaac aaaaggaaat ccactactat
     3361 tagctttgat aaccaaattc tgctactttt tttatttaca tttatttctt ggaaatgatt
     3421 ggccagactc tcctgttcaa agattagaat agacaaaatt gtaaccagta acggaaaaaa
     3481 caaaaaaatc atgagcgaca aatcagtcat tgaaacatga cttcttccaa aagctaaata
     3541 aataggaacc gttaaaagct ctaataaagt aaagagaaaa actaaataaa accctaagct
     3601 attttttaat ttgagacatt cacttcttat catgttctat cactccttta agtaaatacg
     3661 aaactcctat cgttacaact atggaaagtc caactggtaa taaaacttcc caaatactga
     3721 aatttatctt ccctgttaac aaatctcctg atggtttgat atttaacaaa ctttctgtaa
     3781 ctttatagtg ataagtgtat ggtagcaaga accatactgg agtttgtgca acaaaagggg
     3841 caacaattaa acaaatcaag gtattcgcag ctaacaatac gtaggtatta atccacttga
     3901 aaatcaagta tataaagggt aaattccaag aagctgctag taatatagca atcaatgcca
     3961 cacttacttt cataaaatcc accactacaa taccttgaaa cacaaaagca accaaataaa
     4021 gcaaaataat caagactatg ctcgctagta tacctcttag ccaaatcaac aacattttgg
     4081 ccaaatgaat tttccaactc agctttttcc atttcacatt ttgaaaattt ccagcttgct
     4141 cctctgattt tttatcataa agaaaaagca aactcatcaa aaggaataaa aaaccagctt
     4201 cccaccaata aattgaaaaa acactaaaaa tctgtattcc acccataaga aatgctataa
     4261 atagagtcac aaaagggata attaatacca atctaagagt tcctgatttt tttaatttta
     4321 ttgcttctga tgctattatt cttttcatat cacattcctc catgcacaat cttaaagaat
     4381 aactgttcaa tgtcgtcttc tttattgttc gcatgattat aacgaatctt acctttgttc
     4441 aaaataataa tttgactagc tactttactt atttcgtgta actgatgact agaaatcaag
     4501 attgtcacac ctttagcttt aagttttaag attaagttta acaactccgc aataccatca
     4561 ggatccaaac cattagtagg ttcatcaaga attaaaaatt gaggttctgt aagaatagcc
     4621 ataccaattc ccaaacgttg tttcatccct aaagagaatt ttcctgctct tttctttcct
     4681 gtttctgcca aaccaatcac ttctagagtt tcatgaattc tcttatctga aattccaaaa
     4741 agcaaagcct tagttttaag attatcgaaa gcagataaat tcatatatat tgctggagcc
     4801 tcgattaagg ctccaagttg attatttgtc ttttcttgtc catcaaaaaa aatttttcca
     4861 gtatctgcag aaattaaacc aaacaaaatt ttcatcaaag ttgattttcc tgcaccgtta
     4921 actcctaata aaccacagac tgttccagat ttaatatcaa aactgatatc ttgtagcacc
     4981 tgcttttctt tatatgtttt agaaagattt tgaattttta cctgcattat atttcctcac
     5041 tttattttat gtttaaaaaa agtatataaa acaattttca gaatctattc agaaacaaaa
     5101 aaagtaatcc ttagagatta ctaaattact tttttatttt taggataact tctgccccac
     5161 ctttttgagg attactgaga attaagtttc cttgatgttt taaagctaca ccttgagcaa
     5221 aagatagtcc aatcccatag tgtttcccac tacgtccagt atcttctgtg aaaaatagtt
     5281 ttccagcatt tttttttgct tgttcagaaa aaggatgacc attattccag atttcaaaat
     5341 agagatgttt ttcatcatca taaatactca aactaactat tttttcaccc tctttagcat
     5401 actgacaggc attaacaaag atattgataa gtgctcgact taaagctaat gtatttccgt
     5461 aaaaagtggt taaatctgtt tttttaacta gctgataatc cacttgataa gttgttgaca
     5521 actcttccaa ctcaactgat aaatctatca aaaaatcctc cagggagatt ctcgctttgt
     5581 aatcattttc atcattcaaa agttttgtat aactaatcat tgtgttaaaa tacttgtcaa
     5641 aaacagttaa actatttttc attgactcaa taaaatcagc ttgttgttca tttactacag
     5701 tcatctctag cagttcaata tttcctttta atactgttaa aggtgtctta acatcatgtg
     5761 aaagtgcagc aacctggaag gataaatcat gcttttcatg acgctccgct tcaataagga
     5821 aagctaactc cttacttttc gaatataagt tattcagaac ctgatcaaat tcaataattt
     5881 ttgattcctc ttgttcagga aaagtagtta tttcccccat cttcaatgca atcttttgaa
     5941 cggcttgaaa attcttagaa aattctctaa tgagatgata gacagaaaaa ataatgagta
     6001 ttatttcacc aagaaaaaag aaaaggtaag taaattgatt ataagaaatt gaacgaagcg
     6061 tatgatttgt aaattctggc atactgtttt gtcttaaaac aactgaaaaa tgcttattgc
     6121 ttgaataagt ataagtaatt tctccttctg taatattatg tgaagactgt tttgaagcta
     6181 caaaactagg tacatccgac ttgacataat gtcctcccaa aattttactt gtatcattgt
     6241 caaaaataat ataatcatat gggtagtgtt tcatatcacg ttcgatatca gaaatagtta
     6301 aattatctga atctaaagat aaacgaatag tttctgaacc actgatttgt ccaatttgtc
     6361 gtagaaagaa agtcaagccc agtaacaaca ggataagtag acaagtacct atgataattt
     6421 caatgacagc ttgccatatc cgtcgacgca ttgaatattt tttacccatg ccactgatac
     6481 ccaagtcccc gaaccgtttt tatcggatta atatcgtatg gtgcaaactt actcctaatc
     6541 tgataaatat actccgagat tgaccgaaaa agtgcattag aatattcatc atatacgtca
     6601 tcataaatat cctctctcgt ataaacttta gaagttcgtt gtgatagtaa ttcaagaata
     6661 tcgtattcac gacaagtcag tggaattgtt tgaccattaa cacagactcg cctttcttct
     6721 aaataaaatg taattggtcc taaatctcta cgaatctctg aaaaaacatg aactgcatgt
     6781 ttattgcgtt cctctcgctt tatatttgct tccacttttg caaccaactg tttaaggcta
     6841 aaaggcttag taatatagtc atccccacca atacctaagc cgtttataat atcctcttct
     6901 gtatctttcg cactaacaaa gataattgga gttgatattt ctctgcgaat ccttttacaa
     6961 atttctgtcc cttcaatatt tgacatcatg atatctaaca aaatcaaatc aaatccctga
     7021 aaatcagtaa tatccaaggg aagtgaaatg ttttgatgcg tcgcaacttc atagtttctc
     7081 atttctaatg ctgtcttcat taattttaaa atttcctgat catcatcaac tattaaaatt
     7141 ttatacacca ctttacctcc gattgtttag tactcattac ttcattatac cattcattct
     7201 gaagaaatat aatctatcaa tttttagtct ttcttttcaa tataccaagg attgagatac
     7261 acactatacc taaagcaggt aaaaaatctt ctccatctcc agtaacaggt aaaatttctt
     7321 gacttcgtac agaaacagca cctctcgaat ttcgattatt agccattttt tgattaatat
     7381 tataatcaac tgaaattact tcttttgaaa tgttatgaaa atcatttttg atagaaaaat
     7441 tgttatttgt atttctttga atttctttat cttgttcctg tttcattgta tccctagact
     7501 ctttaagatt ctccatcgat ttatggttaa tagcatcatc ctgaccttta tctgtatcta
     7561 agctaaaagc tttatttttc ccattcaata aatcaacaat attcaatact ctattcccat
     7621 taacttctgg agaattcatt agaagaaacc tttttagttg gttaggattc tttattccat
     7681 atttatcaac tactaatgcc agtgccccag atactttagg aacagcaaat gagttgccat
     7741 aaacatattg gtaccagcca gtattagtag ttgtaaaaag ccaatctttc aaataataac
     7801 cctgactgac aaatttatct tgcccatatt ttttaaaatt ggccgttgtg ccagcaggag
     7861 cataaattgc atccgctcca atattactaa aatcagaaat attaccataa ccatctattc
     7921 cacctacggc tattacatcc tcaaatacac tcggtgcatc tacaactttt cccggaacct
     7981 ttatacttct gaaacgctta agaaagttta tcattgtttg gttatcttgt atgtttaaac
     8041 tatcattacc aagagctgcg acaacaatac ttccttttgc tgttgcataa tttattgctg
     8101 acttataatt aagatactct tgataatcat ttgttccatc atcatacgat cctgaaatca
     8161 taagatactg tccagcactt atattgatga ccttgttccc atcatccgca gctcttctta
     8221 ttgctctagc tacccattcc gatttcgaaa gattttcacc aaatactctg tatatattta
     8281 cagtaatccc tggtgctact cctaaaatat taccatttgc tgtaatctga cctgcgactt
     8341 ccgtcccgtg tcccattttg tccacaatat cacttggatt tccagtttca tcaggttctt
     8401 cattatcaaa ccctccctta ggaacaagat ttttaaaata atttcctaaa ctatttgaca
     8461 aatcaggatg ttcttccatg attcctgaat caataattcc aacagaaatt ttctttgagg
     8521 gctggtagag cgcatagctt tctccattat ttgtcacata tttcatatcc cactgataat
     8581 cccaaaaatc atgtgaattt gtataaacac ttgctttctt ttcagaagaa ttacttatca
     8641 atagaggttg tgcctctact ttttgatttt ttaaaggttg tctaagagat accacttcct
     8701 tagctttacg ataagataga ggagaagcag aattatcaat tacaccagat gcatctttag
     8761 aatttgatgg tttttcctta ataagctgag aggaagtaac aaagttagct ctattcttct
     8821 tattatcgag gattttattt ttttgaatcg atgatgttga aacgactact tcactttgct
     8881 caagtagctc atccttagat actggaactg cttctttatt tgtaacgcta tctctcttac
     8941 tgaattcaga actaacttga gtttcttgca acgaaacttt catttctttt tgaacagctg
     9001 atgtctgtaa taaagtttta gcagcaccag ttacatccaa ttcagtcctt gttgtcgatt
     9061 ttactgcagg tgactgctcc cctagattaa tcgaatcagt cgttgatccc tctgttgaag
     9121 ataaaattgc attagaatta tgattaatta attccgtatt aatattattt gagagtaact
     9181 gttgtgaatt tgttgtctcc ccatgcacag ttgctgataa acccaacgaa caaacgataa
     9241 aaaggaaacc tagtattttt ttcactctag tttcctacct tcgttgcaag cttaaaatca
     9301 tcatttatct caacggcaaa tgcttcagta agagattttc ctctaataga atggatttcg
     9361 ccataatccc attccgtcct actctgttta gaatttgaac catccttatc aattctcccc
     9421 cattcagacc tcgggatact tttgccacta actgaatcaa acacacgtac ttcagctaaa
     9481 aaatcctgat attctcccaa ttcttcatca gatacggtgg tgtccgatat actgtaaata
     9541 tttcccatat agtcaatttt tcgtgaatca tttttaccaa taacaaaatt atcatcagaa
     9601 atatcgcttg tcacatcaaa gttttgtaat ctcaaagctt tgaccgcccc cttatcactt
     9661 tctggaagta tcttatagta tctgtcgtta atacccatac atagcgactt gtcagaagcc
     9721 tcataaatat tatttaagac caaagtcaca ctatttttgt tgctacttga taaaagtttc
     9781 tcacttttca tgtcaacaat caacaggtta taaaatttta ctttggaatt gttaacgttc
     9841 tcctgaggaa tctccttatc agttacgaaa tacgatttat tatcaaaaat aaaattagta
     9901 taacttcctt cgtcaaacct cacctttttt tgacttgttt gataacaccc tgataaacct
     9961 gttatcccta ttaaggccac aataagtatt aaatattttc tcatttcctt ttccctcctt
    10021 tcaaaaaatc atcaaaaagt aacagtgctt gtctccaata agtaaaattg attgaatatt
    10081 caaatttcga caataccagt atacagccac ttattccttc aagaaaaccc gtgccacttt
    10141 catctccgta ttcttcaaga atttgctcac tattaacatt aaattcttct atgtatgaat
    10201 caaacttttt tgtatttaat agtcgcttaa ataaagaaca aatttctatt aaaccagaat
    10261 agccatggca aatcatatat gaatcaatac caagttttct ttgcatagct gactctaata
    10321 ttttttctgc tttatctaca aaatagtcat tatccagtgc taatcctccg tataagtata
    10381 gcagactaat acctggacct ccatagcacc atgcatctct aatgaaactt gcttccctaa
    10441 ttactttctc tttttttaat tcatctgcta caagtccatc tttccataga aactgatttt
    10501 tcctttcaag ttcaaacttt tcataaataa aaataatttt ttgcaaagct gacaacgagg
    10561 cttcattact atatcctttt atgtgggcat aagctaagat acagcccgct ccagcaagtc
    10621 catgtgctaa tcccatattc aaacagccta gtggatacat ctcactttct gattgagaca
    10681 tctgattctc cgatttgatg taaagcgata ttagtccttt gttttcttta gtcagatttg
    10741 ataaaaaatt gataatgagt attttcaaat catcatattg ctcgtcattg attaataata
    10801 gataggaaag tatcccagat aaaccttcaa tcacgtcata atcaggagga gtaatgtttt
    10861 ccaaattaaa tccttcaatt ttttctatga cgaaatattc gatatatcta tttaggctgt
    10921 caagaagatt cttatatttt tcgtcatctt ctcgtaaatg taggatactt aatgcaatgc
    10981 cagctgctcc cgaataaagc gatcctgtta aaagcccata tgttgaaagt ttgctaacaa
    11041 tatattcaat ataattgtct atctttttct gatatatctt tgagttatct ttatttttta
    11101 actccgctaa cattaaaatt ataccaggca atcctgtaga gagagtcaac tctccgaaat
    11161 cgaagttttc tttatttttt ctagttctct catcccattg agcaataatt ttttcaacat
    11221 ttctttttat atttttttta ttcatcatta tcctcatatt gctctgaata ataaagttct
    11281 tgatagtatt gacatcttct cagaaggaca tcatgacttc caacatcttc gacctgtcca
    11341 tctttcataa ccacgatttt atttgctttt ctggcagcat tcaaactatg agaaatgaaa
    11401 attgaaatat tattttccga aagagcaaca aaataatcaa atatttcttt ttcagctaca
    11461 ggatcgagtg cagcacttgg ttcatctaaa atataaattg aagctttctt aaagaatgtc
    11521 cttgctaatg caattttttg ccactgacct cctgaaagtt gacgcccttc ttgaaaccaa
    11581 tttcctaact gcgtatcaag tacatattga ttattagttt tcaaaaaatc gagtcctaaa
    11641 ttatctagta ctttaataat tttctcatct tcccattgag aagacaaatc actcaatcct
    11701 atattctctc ttatcgttaa ctcatacttc acaaaatctt ggaacagcac cgatatgttt
    11761 ttctgataaa actcctcagg catcaaacta cttctcattt tgtcgtattg gattattccc
    11821 atagttggtt gatataatcc tgaaattatc tttactagtg tacttttccc ggaaccattt
    11881 tttcctacaa tagcagctaa ttctcctttt tcaaaggata aattgatatt ctttagtgca
    11941 aaggcattcg aattagggta aacatatgat aaattaatta ctttaacagt tcctatatct
    12001 tgattgcata tttcagtatc ttctattttt ttgtgaacta cactttctct ctttaaaaac
    12061 tcaaaaagtt gttccataaa caaactagta ttataaatga tgtaaatatt ttgaatcatt
    12121 gtttgagaat aagtattgat tttagaaata gcttgtatga gacttaccaa attacctata
    12181 agaagttttc ctgctcttac cgaaaggatc atagcaaata tcgtaagaat atttatcaaa
    12241 ttcaaaatga aatcaagaaa aatattgaaa tatgtcttct tacgagcaat agctaaatct
    12301 tggttgataa atcctttctt taattttcca aatttatgaa tgaagtaatt gctaatatta
    12361 tttaatttga tttctttaaa tgaaaaatca tgagtcaata aatatacaat ataccatgtt
    12421 tctctttcag aacttgctct ctgccactgg attaaaaact ctaattgtcc cactctgaga
    12481 aaaagtacca aagataatac tggaacaata aggagtaaaa ttgctacccc aatgttccat
    12541 gttccaataa aaaatagact agatagcaat gagataaacg atgaaagcac aacaatgata
    12601 gcattaaata gctgaaaagg cttgtaagtg ctgtcttgag taactttttc tatgatatta
    12661 tacatatcag cctgctcata atcacttaat tcaagagatg aggtagtcct catgaggcgc
    12721 atattgatac tgtaagaaag tcgcatatca aattttccac taacataact ttccagctgt
    12781 cccagaactg ttgttatcac ttgaacaata aaatagatga taataatata gataagatgt
    12841 ctccctgaac ctagcacaga gtttattaaa tcttgataaa taaaaagact agccaacgga
    12901 acaaaagctg tgatagcatt tagcacaatt aaataaattg cataacgttt ttccaactga
    12961 aaaattaact tcaatgtgct tggaagagta agtaaagtat taaaaaattg ttttgatgtg
    13021 aattctttca cttcatccat ctattagtcc tcatttcatg tattcttccg aaacaaacaa
    13081 cctttgaagt gtgtaataaa ttaatttctc tttatctcgt tcaataccaa ttagtcggtt
    13141 attatggaca tgaatgatac tgtcaataat tgaataaact ttctgaagtt caaaatcttg
    13201 agctatcatt tttaaaaata aattttttat ggcatgcttt aattctttaa aattcttgtc
    13261 ataaaaaatt tggtcaccta gattatcaac tttcagaagc ttaagataat gttcaatctt
    13321 ttcattgaca ttttctttaa cctttttagg actaactaaa ttcaaaaaat taagaatctt
    13381 tttgttatca ttctgaaaga agcatttcag atataaataa ttcaccaaga ttgatacatc
    13441 atcgactttc caatcattat tagtatcttt tatcaatgta agcaaatttg gaataatttt
    13501 agaatcggca caaaatattg cttcggataa ctctaaagta tcaaatccac catatctttc
    13561 tacttcttga tcataaatag aaatatcaaa agttgacatt atcctatttt tctgacttct
    13621 ttttaagatt tcaagaatag atccgtaagc taaaaataaa tctgaacatt ttatacgcaa
    13681 tctaatatgt ggtttaggat cagtatatct taggaagaat agatttccac ccaggtttgc
    13741 tactattttc tgaatatctg gaagatacga cagtaaaaat tcattttgac gatttataga
    13801 aatgtacaac ttgagataaa gccactcgtt aaagggcagt ttttcacgcc gttcaaccga
    13861 aactcttttc tctcttataa atgctctccc ttcattacct aatgctctcg ttctaatgaa
    13921 aggcactaca acatcggcaa ctctcccctt ttgtccttta tttatgatat tttcatcttc
    13981 aaaatattct tgtagctcta taaaatcttt tctttttgag ctcttcttta tcgccgactc
    14041 taaaatttcc atatccaatg ggttttcctg tgataaataa actttattat ctccattgac
    14101 aatataaaac tctttgggaa tttctttgct ttgaataagt tctcttattg tcatcttatt
    14161 atttacattc cttccccaaa ttttccattt agcaggagat attactattt cgtcaaatac
    14221 taaacgtgga atataatcaa agtctctgta aataagttcc caaggtaaat taccaaactt
    14281 gtcatctaat gaaatttcgt aaagaaatct tagctcatta ctgaataacg ttttattgta
    14341 catgcttgta atgtagaatt tcaatacctc ttgagttgaa atgtctcgtg cataaaattt
    14401 ttctttttcg tctattccaa tatagatatt agttaactga acttcattgt gacttgtact
    14461 tgtaaaaaat ggaagtactt tcctcctcat aattgatgta tgcataacgt tagcatgtct
    14521 gatattttct ggaagaaata ctatttcaca cgatgtaatt tctttattct cattttctct
    14581 ttcgacagaa tctactatcg ttctatgata acttgttaac tccggagaga gtgcagaaaa
    14641 tctacctgat gcccctccca aattattatt tccaacgata tcccctaaaa taaaaatatc
    14701 tttttcatac tcctttgcca aattcaaaaa taattctaac ccttgaagtt cacttttctt
    14761 ttctaagtcc attttttggt aatgagactc taagtcgtca agattaatta cattatgatt
    14821 tttaatggct tctacataca tgctgaggta cttttctctc tcctcttctg aatagtatag
    14881 agtactcggt tcggactcat aaaagtcatt tcgaggatga ttataattat atggagctcc
    14941 tatgccaaat gtagaatcaa ataattctgt tatttgtact tcttgatcta caccatattt
    15001 ttcgataaat ttatccttat agtcatccaa atatgttctt cttacagatt ttgtcgtatt
    15061 tcctaaaaac tcagctaaat gttctaattg ttgcttttgt ttaacatcaa aatttatttc
    15121 actatcacta attaaatcaa tttgaatata attatcattc tcaagaattt gtgacatttc
    15181 ctgatatatt tctttcagtt tctcaatacc ttcaccaatt tctatttctg agtattcttg
    15241 aataaacttt tgaacttttt tcagaggaat tatatatttt ttatcttcat ctattgcttc
    15301 aactttagtc aaaaaagtgt cccaagaaaa atctgacaac aaatcttttt gtaaattaga
    15361 gatcaaataa tgattaacta tcagactgcc aagatattgt cccgatagtt ctctatattc
    15421 gtctccatag caaagcgtta cagtttcaca aatatcttca tatttttgat agtcattctc
    15481 acaaaattca gaaataattt gataaacatt cgtatattta atatttactt cttcaagctc
    15541 actactattt atggtataaa cttgaaaaac tcgatctcca aacttataat tcgcattatt
    15601 tctagtaaat gataactttt ttgagaaatc tacttccatt ttatgaacta gacgaatcaa
    15661 ccactgagta tccaatctta taccctttgt agtctttccc attaacttgt actgtgaact
    15721 tttcgaaaaa acaccaattg aagtttcact aaataatcca aatggagttg atcgtaaata
    15781 acttctctta taatacttgt aaatagattc aaataatttt ttaacccttt tcttctttaa
    15841 cagaccagca ttatatttct gcataacatt atagagttta ggattagcta gtagtaactg
    15901 ttccaaaaaa actttatttt tacttatagt ctcaatgact tgagtatatt cagtaaaact
    15961 ccgtttatcg tttggagata atattgtatt tcttactaaa aacggttgag ctttaaatga
    16021 actttttatc atgttttttc ctctctttat ttttataagc tatttagcaa ccctaaataa
    16081 cttataaaaa taggatagta tccatgtctg aactaacaaa atactatcct ttgatttggt
    16141 tatttgctta cgtgaatact acaattacaa gttgctgttt tcatgttaca acccatcaga
    16201 gctcctgttt tacaaccggg tgtacatagc gaaatacttg taatgcgtgg tgatgcacct
    16261 gaatctttct tcgaaacaga taccaaatcc aagttaaaat cttttgtact cattttgagt
    16321 gcctccttat aatttatttt gtagttcctt cgaacgaaat cattgtatct aacaaacttc
    16381 agaatttaat cagagccgtt tattatgatc gcgttatcga caataatatt attgccaata
    16441 ctttctcaag atagaattaa gactgtttta gatttgttaa tgtttctatt gtcagtatag
    16501 ttataagact aggtcattca attatgtcta agactcaata aacctatctc tatattattc
    16561 aggaactaga aaatcaagat attaataaaa ttattaaata ttcgtcagct ataacttaaa
    16621 taaatatttt ttgtaaaaga gattattcta atgattttaa cttgttaatt ttaggctaat
    16681 gaagagtgat ggtattgtcg aggcgtttaa agaatagtcc aacttctgtt gttcctcata
    16741 atttgaaaca ttcagaactc aatcgtttac aattaatcat gataagttca cttgtcctcc
    16801 ccataaatat ttatctattt atctatttat ctatttatct atttatctat ttgtttttgt
    16861 cattttaacg attggataat aacaaaaacc atcaaaatag taaatactat catgaaactc
    16921 aatgactgag atacatttga taaggttact gccgaacgtg cctaaaaata aggtgacggt
    16981 gattttaatc taagttattg gcgtcaaact catgagagat tccttaaaac acatagtatt
    17041 tttaaacccg atatgccaat tatttgttaa gaatacgagc ttgtatacaa aaaagggaat
    17101 taaacaataa aaaatccaag cataaatacc tggataaaaa gtctaacttt tggggtgcac
    17161 atcaattcat ttatttagac tatctcactt aagagttatt tgtaaattta ctttaatatt
    17221 ttaaactaca aaacctacta taaattttac agtaggtttt ggataaagta aatgctgtat
    17281 agttttgctt tggttagttc tttggttagt tctttggttc actttatttt tattaacagt
    17341 aaatctttta aaactaggtt aaaacgcact ttatatgtgt atcaaaaatt tccatttctc
    17401 tttgaaactc cttggctgta attttttata agtcaataaa gacttttagt tattattagg
    17461 gctttttatt aatttataat tgattaatcc accataaatt atatttcctt ttttataatc
    17521 tgtagatctc tttcatccct tcttggttcc ttcatataat ttcaaaaatt tgtatactac
    17581 ctttactaat taccttgaca aatttcattt taaaaattac aattgtaaac aggaggaagt
    17641 aaatgagtaa ttcaaaacta tttgaaaatg atgtaaccga agaagagtta ttaaaaaaaa
    17701 attatcgtaa atatcatggc ggaaaaatgg atatttacta caatgtagca atttgtgaac
    17761 atgcaggtga atgtgttaga ggaaatcctt tagtatttga agttggccgt aagccttgga
    17821 ttatccccga taatggcgat atcgcttcca atcaatcagt aatcaataga tgcccttccg
    17881 gagcactaaa atatttggcg aaggagaaaa actaatgaac attattgaaa gagaaaatct
    17941 atttgaactc ctgtcagata aaggagaagt cattggcgaa atggcctata tgcctatgaa
    18001 taattcaata ataatcactc atactggcgt ttcacttgac tatcgcggtc aaggcctagc
    18061 cgaaaaatta gttcttgccg gaatccaaaa agcaagacgc gaacaattaa aattaggagc
    18121 cacttgccct tatgccgtca aatatttcag agaacacaaa gaagaattaa ctgatgtttt
    18181 gaaataagct aatttttaaa tataaaagac cttttagcgg ggcctttttt atgtattcta
    18241 aattaagcaa gagaaaaatt tttcttcaaa ctttacttta actctgaatt tacttggtaa
    18301 tttaaaaggc ttaataaaat caatcgtcat gttttctata aaattgtgtt gtaaattcac
    18361 aatttttttg ctataataat tcattatttt atctatcaaa caaatcaatt ataaggagta
    18421 tttatggagg aaaaattagc tggtaaagat tacctcttta tagggtcaat gttattcgga
    18481 cttttctttg gtgctggaaa tttaattttt ccaatacata tgggtcaaga ggccggagcc
    18541 gctatttcac aagcaaattt tggtttttta attacggcag tcggctttcc ctttttagga
    18601 attatcgccc tgggaatttc tcaaagtaac ggggtttttg agttagcttc ccgagtcaat
    18661 cgtatttatg cttatatttt tacaatttta ctttatctcg ttattggccc cttttttgct
    18721 cttcctcgct tagcaaccac ttcttttgaa attggaattt cacctttttt aagtcatgaa
    18781 ctccaagctc cactattggc tctttttagt atccttttct ttggaaccgc ctggtttctg
    18841 tccagaaagc caacaaaact cttagattat atcggaaaat ttttaaatcc cctctttttg
    18901 gttttgttag gtattatttt ggtcattgct ttcactcatc cattaggaaa agttagccaa
    18961 gcagaaattg gtaaagccta tcaagcctct cctattttga caggtttcac acaaggttac
    19021 aatactcttg atgccttggc cgccttagct tttggaatca ttatcatcac aactattcgc
    19081 caacgtggcg taaaaaatcc taaaattatt gctaaagaaa ccataaaagc tggcctcatc
    19141 agtgtaggac taatggctat catttacacc tgcctttctt acctaggtac tatgagtctt
    19201 gggcaatttg ctattagtga aaatggtgga attgctctcg ctcaaatttc caaccactac
    19261 ttaggaaatt tcggcatgat tatcttagca ctcattgtca tcatcgcttg cttaaaaaca
    19321 gccgttggct taatgtctgc cttttctgaa acctttgccg aattatttcc taaaaaagaa
    19381 taccgttttt atctcctcat cgtaagtatt cttccttgca tctttgcaaa tattggtttg
    19441 acaaaaatta tagaactttc agttccagtc ctcatgtttt tatatccctt agccattatc
    19501 cttattttat tagctttatt aagcccgctt tttaaacatt ctagactcgt ttatcagata
    19561 acaactgctt ttacactttt agcggctatt atcgacggac tcaatgctct tccagccagt
    19621 cttcacacaa ttactttcat atcagtaata attaattttg ctaaagactt tctacccttt
    19681 ttctccctag gaatgggttg gattcttccg gcggttttag gctttataat cggatgttta
    19741 tgtcaaatcg cgattactgt atataaaaat aaaaagtctt caacactttc ataaaagttg
    19801 agagcctaca atatataaaa ggagtttcaa ataattgata actccttttc ttttacatca
    19861 actcagataa ttaatttttt gattttctct taatataaat cattccaagc accccagaaa
    19921 tcaatagaag tattcccaac actttgaaaa aatcccttgg gctatccccc gttttaggca
    19981 actcttcaga cgtttctgat tccattgaag aagacgaagt cgacattact tgtgaggatg
    20041 aactaggagt agtaattgat tggtcggttt tttcaggagc ttcttcttta acagggatga
    20101 ttgtatttat aaaattatac ccctcttgtt gactcgtgta attactaaca gacacctctt
    20161 ttacatcata atcgtaaagt ttcccacttt catcatactt atccaaattg gtaaacgaat
    20221 atttccaatt ttctttagcc gtcacatctc gtgaatcaac tttctctcca ttccgatata
    20281 actcaatact aataaaactt ggtcttaaac cacgtgcatt attgtcatca atccaagttt
    20341 tctctccaga aatagaaagt ttcatacttg catttccatt tccaccattg ttaggagtat
    20401 gaacttctac tacctgtttt tcaatatttt ctcccgtcaa ttctcctcta ttttcatact
    20461 gttgagaaag ccctccatcc gttgccctcg ttgaataatc gataataatc gtatttgaaa
    20521 tatcacctaa attcacggta aatccgttca cgccattttc taaaatacta gcctgaggat
    20581 aatagctatc aacattataa ttctctccat cactactata agtcacatta gctaccgaaa
    20641 tcgaaccaga aactaaattc tgattcccac caataatatc agtataaata gctttctgaa
    20701 tattttcttt agcataattg atccgaacct gccaatgaat taaggttgaa tcattctcgt
    20761 caacccatcc ccatttataa agtacctcat ctttatccgg tcctgttgcc ggaccaatgt
    20821 taacctctgt tgttcctcca tctttccaat caactactac ccttgtgtct tcctctactt
    20881 tttgttcatc ccaattaacc caaacggaaa gtgtaccttt aatgtctgaa gttgcatttt
    20941 caacaagttt tgaaaaagta acagttacca cccccgtaag atgattggca accgccgttc
    21001 cgataatatt tccagcttca tcttttattt caaaagtaat atcttttgat aaagttaata
    21061 aatcaggaac attgacactc attgtatccc cctgagaaac gcttcccact ggaatatcaa
    21121 aatcccaatg agcctgaaca tcatcataaa taccaaaatc tgttttcgga tttcccaaat
    21181 catcagtcag ttcatgtccc gttataaatt tatttccata gtcagcagca aatacatttg
    21241 aaggtttaaa taaattaatt ccaaccaagc acatcaataa actcagaacc attaataatt
    21301 taaatgactt attcttcgcc ttcatgaata tctccttctt attttctctt attattgtgt
    21361 cccttcactt aagagccaat gtttgatagt tttccaatta tccttcgtaa caatcaacct
    21421 aggaatatta ctatatagtg tttcattagt cactacacct ggagatagtg tgaatattcc
    21481 ttgaattcca tcttgtagca tataatcttc taagtcttta ttttgtgctc cataaggata
    21541 agcaaaaact tttccttttt gatctaactt ctcatcaaat gctttctgac ttttttggta
    21601 atctttttgc actacttttt ttgaaatatt agtagataaa atcggttcaa agttttcttg
    21661 ataatgtaag tcattcgtat gtagtcctga agtaaccaaa ggattttcat tcattttctt
    21721 tatttctttc caagtcgaca tttgtgaacc atcaatggtt tgtccaactt ttcccgtgat
    21781 aatgaattgc gtaaagggta agtctaattt tttcattatt ggataagcgt tctctggcaa
    21841 agacttatca atgtcatcaa aagtaatcac tactgctttg ccaatcacct cttttttatt
    21901 aagcttctct atcagttctg aactagtcaa aactttaata tgatttttct ttaaaaatgt
    21961 catttgctgt tcaaaatctt gcaagaatac attatattca tggagttgag aattatgcga
    22021 aattgaataa gcgaaatttg taaccaccgt atcttttaac acacggtgat aacaaagaac
    22081 aataattcca tcattgtctt taagcaaact ctcataagca aaatctggct gctccttttt
    22141 tccatcttgt acatattttt ttgtttcacg tgtggacata aacaccaaga tagcaataag
    22201 accaaacatc aatatcaaaa aaatattctt tttactaaat ttcatattat aaatctaagc
    22261 ctccttcgtt aaaatataaa gactaggaat cgttaatatt gaaagaagac aaaacaaatc
    22321 ataaattata tcttcccaat ttgttattgg aaacccaatg attacaaaaa cagagataat
    22381 tccatcacta tatatcccca gcaaagagat taataaaaga atgaaaacaa ttaatataaa
    22441 cagccaacat agtgaaacag ccaagaattc caaaaactgt cgttttttca tttttttacg
    22501 tattactaat tccattatta cacccctcta tcaggacttt cccattttcc tttatttgtc
    22561 cgattagtta aaacaacaag ttcagcagaa agagcactaa tcaaatttag aaaccaataa
    22621 gcaactagat aagctggaaa tattaattta tcagtcaagg ataagcgact ctccccttta
    22681 tcattattaa gtcctaaaaa gaatacaaaa aatgaaataa gaacaaaaat cacgataatt
    22741 tgacccgata ctttgaattc ttgatttaac agcatttgga gaaaatactg ataagattct
    22801 attaagaaaa accaactcca aatatgacta caaatcattt caatcaaaag aaaccgatgt
    22861 ttaaattctc ctcttttaaa aacccatgat aaatttgaaa ttaatacttc tactccacca
    22921 actgcccatc ttctccgttg ctttaaaaga gattttaaat tttcaggaac gagaatatag
    22981 cttaaggctt tagggacata tttgactttc cattgattac gatgaagtcg ccaagtgaca
    23041 tcaatgtctt ccgtcatcac ttcggtatta aagcccccaa tttctttcaa agcctctaca
    23101 cgatacataa caatcacacc tgatacggtc attatagcgc ctagaaaaag actttgtgct
    23161 ctcttaatcg catcaatcac acttaaatac tctaaggttt gtaatttccc caatagagtt
    23221 gttctgtttc taacaatagg tcgtccagtc acagccccaa tatctgaact agaagttaat
    23281 tcggccaata aataagatag agcatcttta gaaagatatg aatccgcatc aataacaagc
    23341 atatacttgc tgttaacttg ttgcaaagca acatttaaag ccgtggcttt tcccttattt
    23401 tccttttgct caagaatagt taatgtttcc caatcgtcga aagatttttt tacttcataa
    23461 agtttctcca aagtgcggtc actactctta tcatcaacaa taaagatctc tagggaaggg
    23521 taatttagat tatgtagtga taataaaact tcctcaatcg tttcttcttc attgtacgca
    23581 gaaataacaa tactaatttt ttcaaattct tttgtttcat caattgcttt cttatctctt
    23641 tctttccacc gagataaaaa agcaccactt gcccaaatga aggacaagat aatcggataa
    23701 taaacaacat aaacatctac cattgttgag attatcatag ttttaatttt cctttctttc
    23761 tttttttctc ttaaaaggga aatttaaaac ttttcccaca aaaattccta gtaatgccgc
    23821 actagtaaag gctactggaa taataatcgg tcctgctatc actcgttgac ttaagtttgg
    23881 aatttcatgc ttaaaaaatc catagacaaa ctgatccgtt aaatcggata taagatagat
    23941 agtcaaagta gcggtagata gagcctttag caacctaacg ctccattttg gaatgggaat
    24001 tctccacaag attgctataa ctaatactgt cattatggct gtttgataac caaaataatc
    24061 attgtggtct agccactgga attcttgatt ccaacttgca aaagtgtccg tcaaagtaaa
    24121 aattgtaagt gcacttaaga atgctgtaac aagttttcct attgaaattt tctttatttc
    24181 attttgataa gtataaaggc aagctccgat aaaataataa ctaacgggat aacaaatttg
    24241 ccaatagtct ggaataactt ttccaaaact atttaataaa gagggtaaga atgttagcaa
    24301 acttgcgatg aagacaatat ataaatgata atttttgatt tcttttttat aattccagat
    24361 aatatttaat aaagggataa aaagataaag tcctaaatac atttcaacat accaagagta
    24421 agaatcggtt gaataatcaa aaattccatt tatggctgta gagaagtcgc ttccttttcc
    24481 aacaagagat agaactcccc atactaataa agatatacct atataagaaa tgatgacagg
    24541 aactattccc agaacatatt gagcatttaa ctcttttcga ttcattaaaa atccagttgc
    24601 tactaaaaac aagggcacac aagtaattaa aatcgttctt atcccaatcc aaaaaattcc
    24661 taaagtggaa tgaattgtca tatcataaaa gcccgaattt aataaaaaat ggaccgaaat
    24721 gacaaagaat attgcacaac ttttcattaa atctattgat gaattacgtt tcatttttct
    24781 atatttatag cagacaaatt ttgctactgt aaatcctttc tttaatttgg gttataaccg
    24841 ctcaattcaa actttgtaat tacttttcct ttacatcact aagttgtctc gaaatcatgt
    24901 cattatccta actttaattt aatatggatt tataattatc gaaaatcatt aatttttgat
    24961 tgcaatccac gaactaatca cagtataaca taataaaaag aaatattgta atatttaaat
    25021 tacatataca ctcaatataa taatattttt cacctttaat tattactaaa aaccataaag
    25081 taaaatattt ataaattgaa aaatcgcaac aaccctttat ataatagcac ttttgctaat
    25141 tttaagcata ataggtaata ctctaaatag caaaactaga aatcaaaaac atatattagg
    25201 ttttaattag taacatacaa aaaaagcact tactgaagta agtacttttg catcaattta
    25261 ccatattttt attttaaaaa cttcttttat tcctgacaat attagtgtag gtagagcagg
    25321 aataaaaatc acaagtagat atacaggtaa tgttaactga gcagttccca tcacactatt
    25381 gaaaaacgga atgattgtta ctaaaaatga agaaactcct gcaaataaca ctgctccaac
    25441 aagtctaata ttcccaaaag gattgcgtct gaacaatgtt cttgaacttc tcgcatcaaa
    25501 tacatgccat aattgtccat aaactaaagt cagaaatgca actgtttgtg cttcactagc
    25561 gttcaatcca ttttgagcag ctaggagaaa tccaagataa accatcgctc ccataactgt
    25621 tcccctaatc aaaaccctag accacgtgtg gttagcaaga atagattcat tagggttccg
    25681 tggtttttct ttcatcaaat ctgtttcggc aacatcataa cccaaagaaa aagatggaat
    25741 cgcgtcactc accatattaa cccaaagaac cattaaagca gtcaatgtcg gagtcattgc
    25801 tgctacattt ccaacactac ttctaaataa aactaaacct aatacaaggg ccaaaacttc
    25861 agcaacattt gttgtcagtt cgtgtctcat aaagtttttt atattagcat agatagtacg
    25921 accgctataa actgattttt ctatcgttgt aaatttatca tctagtaaaa tgagatctgc
    25981 agaatcttta gttacttctg taccagtaat tcccatcgcc actccaatat ca
//
