LOCUS       NZ_MTJR01000005        26032 bp    DNA     linear   CON 23-AUG-2024
DEFINITION  Lactococcus lactis strain 417 contig_5, whole genome shotgun
            sequence.
ACCESSION   NZ_MTJR01000005
VERSION     NZ_MTJR01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Lactococcus lactis
  ORGANISM  Lactococcus lactis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Lactococcus.
REFERENCE   1  (bases 1 to 234637)
  AUTHORS   Ho,V., Lo,R., Bansal,N. and Turner,M.S.
  TITLE     Characterization of Lactococcus lactis isolates from herbs, fruits
            and vegetables for use as biopreservatives against Listeria
            monocytogenes in cheese
  JOURNAL   Food Control (2017) In press
REFERENCE   2  (bases 1 to 234637)
  AUTHORS   Lo,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2017) School of Agriculture and Food Sciences, The
            University of Queensland, Hartley Teakle Bldg (No. 83), Slip Rd, St
            Lucia, Brisbane, QLD 4072, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. Jun 2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 793.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002563455.1-RS_2024_08_23
            Annotation Date                   :: 08/23/2024 15:24:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,353
            CDSs (total)                      :: 2,288
            Genes (coding)                    :: 2,273
            CDSs (with protein)               :: 2,273
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 56
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 15
            CDSs (without protein)            :: 15
            Pseudo Genes (ambiguous residues) :: 0 of 15
            Pseudo Genes (frameshifted)       :: 5 of 15
            Pseudo Genes (incomplete)         :: 10 of 15
            Pseudo Genes (internal stop)      :: 4 of 15
            Pseudo Genes (multiple problems)  :: 3 of 15
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:59:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 137515
            Orig. end                         :: 163547
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MTJR01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26032
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26032
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26032
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16032](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16032
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(795..808)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 21.61"
                     /tool="antismash"
     gene            1225..2256
                     /locus_tag="BW153_RS02940"
                     /old_locus_tag="BW153_02930"
     CDS             1225..2256
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003129606.1"
                     /locus_tag="BW153_RS02940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_02930"
                     /product="acyltransferase"
                     /protein_id="WP_003129606.1"
                     /transl_table=11
                     /translation="MKRNSSIDLMKSCAIFFVISVHFLLNSGFYDMTIHSTLAIFWIGI
                     RTILITCVPLFLVATGFLMNRKELSAQYVLGIVPVIISYIGISLLVWGVLSLVGKGSDF
                     STAINGIFDYSTDSYSWYVEMYLGLYLFIPLLNIIWNYKKEIKNYHLYIVFIASLLTFL
                     PSLLNSFGKVIPDYWQICYPVSYYFIGAYLYTYQNEIKKISIGKLVTAFLSALTIFTLT
                     DTFASWNQEFQWLDHNDYFGYQTAIMTVLVIAILWRTPIPKWSVRLLKALSTATLTIYL
                     ISDLTDQFVYGFFKHEIPNLSQRVIAGPIIIPVAFTSAALLGIFVGKVLNIPFKRKKER
                     KEN"
     gene            2261..3481
                     /locus_tag="BW153_RS02945"
                     /old_locus_tag="BW153_02935"
     CDS             2261..3481
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864227.1"
                     /locus_tag="BW153_RS02945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_02935"
                     /product="glycosyltransferase"
                     /protein_id="WP_017864227.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 6.4e-31,
                     bitscore: 101.2, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIISTMVDVYVVYYPIILSFIWASGAFLSRWKERDKKAIDETKEF
                     EKISIVISAYNEEETIEEVLLSLRNLNYPSLEIFIVDDKSSDRTLEKLYEVKKSFDDWE
                     TLTILEQKENKGKATALNVALQQVNSKYMLVIDADSYLSKDALSYLLAELTSSSDIGAV
                     TGRPIVRNRTTLLGKLQTLEYLSVIDAIKRAQSLFLGAIMTVSGVIVMYRVEALKEIGG
                     FNTEVMTEDIDVTWRLHRNQWKVKYVPKALSYILVPENLKSLLKQRRRWAVGGVEVLIS
                     NLSWVFKRGEFKHRFLLIEMICSHIWSWFFLIESYQYFLQMLLNQEFKVSGQIIVIFVL
                     ISFFVFFLGLNNDKGESRLSLTDKLIFPAYLVAYWFLNLISALSAELVVLTNRTNKGKW
                     ESPDRGV"
     gene            3754..4647
                     /locus_tag="BW153_RS02955"
                     /old_locus_tag="BW153_02945"
     CDS             3754..4647
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864229.1"
                     /locus_tag="BW153_RS02955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_02945"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_167593620.1"
                     /transl_table=11
                     /translation="MKFSKKNIFLILMFGLIAILVFMSTRETKKYVQDGKKEQPDFAYE
                     SLLKDNDGIIVLCYHRVLKDTVVTNFAYSISHNSQLHEYNVFLQDFEQQMTFLKKNHIK
                     VLTSSELIEKLNKKEVIGKAVVITFDDIDKSLPENAYPIMKKLDLPFTQFIITGKVGQT
                     IDGSQMSTWKEIKKMNENPLITSGLHTNDLHYQENFEPILSTNISKKVVQKDYQKSQKA
                     FGEKLDQKGKVFAYPYGAQNKDLEDYMLQDGIQGIFTLSPGVVNNETLYSNIPRLIVTK
                     DNWKTIKHWLLSEGTQ"
     gene            4674..6128
                     /locus_tag="BW153_RS02960"
                     /old_locus_tag="BW153_02950"
     CDS             4674..6128
                     /GO_function="GO:0005518 - collagen binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864230.1"
                     /locus_tag="BW153_RS02960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_02950"
                     /product="LPXTG cell wall anchor domain-containing protein"
                     /protein_id="WP_098396288.1"
                     /transl_table=11
                     /translation="MKAKNKSFKLLMVLSLLMCLVGINLFKTSNVFAADYGNKFITGHE
                     LTDDLGNTKTDFGIYDDVQAHWDFDIPVGSVSQGDTMSVNVPDLLTLSKDITFEIKDEA
                     GNIIGTAVANHLTGVVTVTFSKLVENATSDIKGSFSVWVNWDEQKVEEDTKVVVDWKDG
                     GTTEVSIGPATGPDKDEVLYKWGWVDENDSTLIHWQVRINYAKENIQKAIYTDIIGGNQ
                     NLVSGSISVANVTYSSNGENYNVESYYPQASILENGVNGFTVNLGDISNTIIVDYSTKA
                     TDGGLSQQYENRGELTGENIEKQVVEVHTPNNGGNGNASMKLSISGEKTWIDENNARGL
                     RPSFISIVLYRNGEKVDSRDVTAKENWKYSFTDLDKYDESGKLYDYDVKEVPVSNYTSQ
                     QEGYNFINTIIPVKEETPEKPDQSITTPSSSSQVMSVSSSSMESEPSEELPKTGDSPRD
                     FFKVLGILLLISGGLGMIYIRRKSKI"
     misc_feature    4676..4685
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 16.78"
                     /tool="antismash"
     gene            complement(6218..7576)
                     /gene="brnQ"
                     /locus_tag="BW153_RS02965"
                     /old_locus_tag="BW153_02955"
     CDS             complement(6218..7576)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015658 - branched-chain amino acid
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0015803 - branched-chain amino acid
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="brnQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003129615.1"
                     /locus_tag="BW153_RS02965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_02955"
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="WP_098396292.1"
                     /transl_table=11
                     /translation="MEEKLAGKDYLFIGSMLFGLFFGAGNLIFPIHMGQEAGAAISQAN
                     FGFLITAVGFPFLGIIALGISQSNGVFELASRVNRIYAYIFTILLYLVIGPFFALPRLA
                     TTSFEIGISPFLSHELQAPLLALFSILFFGTAWFLSRKPTKLLDYIGKFLNPLFLVLLG
                     IILVIAFTHPLGKVSQAEIGKSYQASPILTGFTQGYNTLDALAALAFGIIIITTIRQRG
                     VKNPKIIAKETIKAGLISVGLMAIIYTCLSYLGAMSLGQFAISENGGIALAQISNHYLG
                     NFGMIILALIVIIACLKTAVGLMSAFSETFVELFPKKEYRFYLLIVSILPCIFANIGLT
                     KIIELSVPVLMFLYPLAIILILLALLSPLFKYSRLVYQITTAFTLLAAIIDGLNALPAS
                     LHTITFISVIINFAKDFLPFFSLGMGWILPAVLGFIIGCLCQIAITVYKNKKS"
     gene            complement(7813..8085)
                     /locus_tag="BW153_RS02970"
                     /old_locus_tag="BW153_02960"
     CDS             complement(7813..8085)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011675645.1"
                     /locus_tag="BW153_RS02970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_02960"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_021214922.1"
                     /transl_table=11
                     /translation="MNIIERENLFELLSDKGEVIGEMAYMPMNNSIIITHTGVSLDYRG
                     QGLAEKLVLAGIQKARREQLKLGATCPYAVKYFREHKEELTDVLK"
     gene            complement(8085..8357)
                     /locus_tag="BW153_RS02975"
                     /old_locus_tag="BW153_02965"
     CDS             complement(8085..8357)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864233.1"
                     /locus_tag="BW153_RS02975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_02965"
                     /product="(4Fe-4S)-binding protein"
                     /protein_id="WP_015425977.1"
                     /transl_table=11
                     /translation="MDNSKLFGEAANEEQLLKNDYRKYRGENMDIYYNVAICEHAGECV
                     RGNPLVFEVGRKPWIIPDNGDVASNQSVINRCPSGALKYLAKEKN"
     misc_feature    8688..8704
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 20.28"
                     /tool="antismash"
     misc_feature    complement(9183..9203)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 24.64"
                     /tool="antismash"
     gene            9720..9893
                     /locus_tag="BW153_RS02980"
                     /old_locus_tag="BW153_02970"
     CDS             9720..9893
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570405.1"
                     /locus_tag="BW153_RS02980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_02970"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_015425978.1"
                     /sec_met_domain="TIGR03731 (E-value: 2.6e-23, bitscore:
                     75.5, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 1.2e-06, bitscore:
                     21.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTKDFNLDLVSVSKKDSGASPRITSISLCTPGCKTGALMGCNMK
                     TATCNCSIHVSK"
     CDS_motif       9720..9788
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSTKDFNLDLVSVSKKDSGASPR"
                     /locus_tag="BW153_RS02980_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9789..9893
                     /prepeptide="core"
                     /locus_tag="BW153_RS02980_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="26.70"
                     /molecular_weight="3313.0"
                     /monoisotopic_mass="3310.6"
                     /core_sequence="ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSTKDFNLDLVSVSKKDSGASPR"
                     /leader_location="[9719:9788](+)"
                     /alternative_weights="3331.0"
                     /alternative_weights="3349.0"
                     /alternative_weights="3367.0"
                     /alternative_weights="3385.1"
     gene            10001..12982
                     /locus_tag="BW153_RS02985"
                     /old_locus_tag="BW153_02975"
     CDS             10001..12982
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864234.1"
                     /locus_tag="BW153_RS02985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_02975"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_058223458.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.1e-86, bitscore:
                     284.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.9e-08,
                     bitscore: 28.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.2e-21, bitscore:
                     71.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKSSFKAQPFLVRNTILSPNDKRSFTEYTQVIETVSKNKVFLEQ
                     LLLANPKLYNVMQKYNAGLLKKKRVKKLFESIYKYYKRSYLRSTPFGLFSETSIGVFSK
                     SSQYKLMGKTTKGIRLDTQWLIRLVHKMEVDFSKKLSFTRNNANYKFGDRVFQVYTINS
                     SELEEVNIKYTNVYQIISEFCENDYQKYEDICETVTLCYGDEYRELSEQYLGSLIVNHY
                     LISNLQKDLLSDFSWDTFLTKVEAIDEDKKYIISLKKVQKFIQEYSEIEIGEGIEKLKE
                     IYQEMSQILENDNYIQIDLISDSEINFDVKQKQQLEHLAEFLGNTTKSVRRTYLDDYKD
                     KFIEKYGVDQEVQITELFDSTFGIGAPYNYNHPRNDFYESEPSTLYYSEEEREKYLSMY
                     VEAIKNHNVINLDDLESHYQKMDLEKKSELQGLELFLNLAKEYEKDIFILGDIVGNNNL
                     GGASGRFSALSPELTSYHRTIVDSVERENENKEITSCEIVFLPENIRHANVMHTSIMRR
                     KVLPFFTSTSHNEVQLTNIYIGIDEKEKFYARDISTQEVLKFYITSMYNKTLFSNELRF
                     LYEISLDDKFGNLPWELIYRDFDYIPRLVFDEIVISPAKWKIWGRDVNNKMTIRELIQS
                     KEIPKEFYIVNGDNKVYLSQENPLDMEILESAIKKSSKRKDFIELQEYFEDENIINKGQ
                     KGRVADVVVPFIRTRALGNEGRAFIREKRVSVERREKLPFNEWLYLKLYISINRQNEFL
                     LSYLPDIQKIVANLGGNLFFLRYTDPKPHIRLRIKCSDLFLAYGSILEILKRSQKNRIM
                     STFDISIYDQEVERYGGFDTLELSEAIFCADSKIIPNLLTLIKDTNNDWKVDDVSILVN
                     YLYLKCFFQNDNKKILNFLNLVSPKKVKENVNEKIEHYLKLLKVDNLGEQIFYDKNFKE
                     LKHAIKNLFLKMIAQDFELQKVYSIIDSIIHVHNNRLIGIERDKEKLIYYTLQRLFVSE
                     EYMK"
     aSDomain        10424..10687
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BW153_RS02985_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.60E-09"
                     /identifier="RREFam001.1"
                     /label="BW153_RS02985"
                     /locus_tag="BW153_RS02985"
                     /protein_end="229"
                     /protein_start="141"
                     /score="28.7"
                     /tool="antismash"
                     /translation="FTRNNANYKFGDRVFQVYTINSSELEEVNIKYTNVYQIISEFCEN
                     DYQKYEDICETVTLCYGDEYRELSEQYLGSLIVNHYLISNLQK"
     gene            12993..14795
                     /locus_tag="BW153_RS02990"
                     /old_locus_tag="BW153_02980"
     CDS             12993..14795
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015425980.1"
                     /locus_tag="BW153_RS02990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_02980"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_058205264.1"
                     /transl_table=11
                     /translation="MDEVKEFTSKQFFNTLLTLPSTLKLIFQLEKRYAIYLIVLNAITA
                     FVPLASLFIYQDLINSVLGSGRHLIYIIIIYFIVQVITTVLGQLESYVSGKFDMRLSYS
                     INMRLMRTTSSLELSDYEQADMYNIIEKVTQDSTYKPFQLFNAIIVVLSSFISLLSSLF
                     FIGTWNIGVAILLLIVPVLSLVLFLRVGQLEFLIQWQRASSERETWYIVYLLTHDFSFK
                     EIKLNNISNYFIHKFGKLKKGFINQDLAIARKKTYFNIFLDFILNLINILTIFAMILSV
                     RAGKLLIGNLVSLIQAISKINTYSQTMIQNIYIIYNTSLFMEQLFEFLKRESVVHKKIE
                     DTEICNQDIGTVKVINLSYVYPNSNAFALKNINLSFEKGELAAIVGKNGSGKSTLVKII
                     SGLYQPTMGIIQYDKMRSSLMPEEFYQKNISVLFQDFVKYELTIRENIGLSDLSSQWED
                     EKIIKVLDNLGLDFLKTNNQYVLDTQLGNWFQEGRQLSGGQWQKIALARTFFKKASIYI
                     LDEPSAALDPVAEKEIFDYFVALSENNISIFISHSLNAARKANKIVVMKDGQVEDVGSH
                     DVLLRRCQYYQELYYSEQYEDNDE"
     misc_feature    complement(13001..13016)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     gene            14785..16032
                     /locus_tag="BW153_RS02995"
                     /old_locus_tag="BW153_02985"
     CDS             14785..16032
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570408.1"
                     /locus_tag="BW153_RS02995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_02985"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_235585319.1"
                     /sec_met_domain="LANC_like (E-value: 9.1e-74, bitscore:
                     241.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNKKNIKRNVEKIIAQWDERTRKNKENFDFGELTLSTGLPGIIL
                     MLAELKNKDNSKIYQKKIDNYIEYIVSKLSTYGLLTGSLYSGAAGIALSILHLREDDEK
                     YKNLLDSLNRYIEYFVIEKIEGFNLENITPPDYDVIEGLSGILSYLLLINDEQYDDLKI
                     LIINFLSNLTKENKGLISLYIKSENQMSQSESEMYPLGCLNMGLAHGLAGAGCILAYAH
                     IKGYSNEASLSALQKIIFIYEKFELERKNQFLWKDGLVADELKKEKVIREASFIRDAWC
                     YGGPGISLLYLYGGLALDNDYFVDKAEKILESAMQRKLGIDSYMICHGYSGLIEICSLF
                     KRLLNTKKFDSYIEEFNVNSEQILEEYGDESGTGFLEGISGCILVLSKFEYSINFTYWR
                     QALLLFDDFLKGGKRK"
     gene            16029..16766
                     /locus_tag="BW153_RS03000"
                     /old_locus_tag="BW153_02990"
     CDS             16029..16766
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570409.1"
                     /locus_tag="BW153_RS03000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_02990"
                     /product="NisI/SpaI family lantibiotic immunity
                     lipoprotein"
                     /protein_id="WP_058221042.1"
                     /transl_table=11
                     /translation="MRKYLILIVALIGITGLSGCYQTSQKKVRFDEGSYTNFIFDNKSY
                     FVTDKEIPQENVNNSKVKFYNLLIVDMKSEKLLSSSNKNSVTLVLNNIYEASDKSLCMG
                     INDRYYKILPESDKGAVKALRLQNFDVTSDISDDNFVIDKNDSRKIDYMGNIYSISDTT
                     VSDEELGEYQDVLAEVRVFDSVSGKSIPRSEWGRIDKDGSNSKQSRTEWDYGEIHSIRG
                     KSLTEAFAVEINDDFKLATKVGN"
     gene            16768..18816
                     /locus_tag="BW153_RS03005"
                     /old_locus_tag="BW153_02995"
     CDS             16768..18816
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570410.1"
                     /locus_tag="BW153_RS03005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_02995"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_098396295.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 6e-49, bitscore:
                     160.5, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKILGFLFIVCSLGLSATVHGETTNSQQLLSNNINTELINHNSN
                     AILSSTEGSTTDSINLGEQSPAVKSTTRTELDVTGAAKTLLQTSAVQKEMKVSLQETQV
                     SSEFSKRDSVTNKEAVPVSKDELLEQSEVVVSTSSIQKNKILDNKKNRANFVTSSQLIK
                     EKPSNSKDASGVIDNSASPLSYRKAKEVVSLRQPLKNQKVEAQPLLISNSSEKKASVYT
                     NSHDFWDYQWDMKYVTNNGESYALYQPSKKISVGIIDSGIMEEHPDLSNSLGNYFKNLV
                     PKGGFDNEEPDETGNPSDIVDKMGHGTEVAGQITANGNILGVAPGITVNIYRVFGENLS
                     KSEWVARAIRRAADDGNKVINISAGQYLMISGSYDDGTNDYQEYLNYKSAINYATAKGS
                     IVVAALGNDSLNIQDNQTMINFLKRFRSIKVPGKVVDAPSVFEDVIAVGGIDGYGNISD
                     FSNIGADAIYAPAGTTANFKKYGQDKFVSQGYYLKDWLFTTTNTGWYQYVYGNSFAAPK
                     VSGALALVVDKYGIKNPNQLKRFLLMNSPEVNGNRVLNIVDLLNRKNKAFSLDTDKGQD
                     DAINHKSMENLKESRDTMKQEQDKEIQRNTNNNFSIKNDFHNISKEVISVDYNINQKMA
                     NNRNSRGAVSVRSQEILPVTGDGEDFLPALGIVCISILGILKRKTKN"
     gene            18885..19571
                     /locus_tag="BW153_RS03010"
                     /old_locus_tag="BW153_03000"
     CDS             18885..19571
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014734918.1"
                     /locus_tag="BW153_RS03010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_03000"
                     /product="response regulator transcription factor"
                     /protein_id="WP_014734918.1"
                     /transl_table=11
                     /translation="MYKILIVDDDQEILKLMKTALEMRNYEVATHQNISLPLDITDFQG
                     FDLILLDIMMSNIEGTEICKRIRREISTPIIFVSAKDTEEDIINGLGIGGDDYITKPFS
                     LKQLVAKVEANIKREERNKHAVHVFSEIRRDLGPITFYLEERRVCVNGQTIPLTCREYD
                     ILELLSQRTSKVYTREDIYDDVYDEYSNALFRSISEYIYQIRSKFAPYDINPIKTVRGL
                     GYQWHG"
     gene            19564..20907
                     /locus_tag="BW153_RS03015"
                     /old_locus_tag="BW153_03005"
     CDS             19564..20907
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864239.1"
                     /locus_tag="BW153_RS03015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_03005"
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="WP_012897846.1"
                     /transl_table=11
                     /translation="MGKKYSMRRRIWQAVIEIIIGTCLLILLLLGLTFFLRQIGQISGS
                     ETIRLSLDSDNLTISDIERDMKHYPYDYIIFDNDTSKILGGHYVKSDVPSFVASKQSSH
                     NITEGEITYTYSSNKHFSVVLRQNSMPEFTNHTLRSISYNQFTYLFFFLGEIILIIFSV
                     YHLIREFSKNFQAVQKIALKMGEITTFPEQEESKIIEFDQVLNNLYSKSKELAFLIEAE
                     RHEKHDLSFQVAALSHDVKTPLTVLKGNIELLEMTEVNEQQADFIESMKNSLTVFDKYF
                     NTMISYTKLLNDENDYKARISLEDFLIDLSVELEELSTTYQVDYQLVKKTDLTTFYGNT
                     LALSRALINIFVNACQYAKEGEKIVSLSIYDDEKYLYFEIWNNGHPFSEQAKKNAGKLF
                     FTEDTGRSGKHYGIGLSFAQGVALKHQGNLILSNPQKGGAEVILKIKK"
     gene            21006..21683
                     /locus_tag="BW153_RS03020"
                     /old_locus_tag="BW153_03010"
     CDS             21006..21683
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012897845.1"
                     /locus_tag="BW153_RS03020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_03010"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_015425986.1"
                     /transl_table=11
                     /translation="MQVKIQNLSKTYKEKQVLQDISFDIKSGTVCGLLGVNGAGKSTLM
                     KILFGLISADTGKIFFDGQEKTNNQLGALIEAPAIYMNLSAFDNLKTKALLFGISDKRI
                     HETLEVIGLAETGKKRAGKFSLGMKQRLGIGMAILTEPQFLILDEPTNGLDPDGIAELL
                     NLILKLKAKGVTILISSHQLHEISKVASQIIILNKGKIRYNHANNKEDDIEQLFFKIVH
                     GGM"
     gene            21685..22413
                     /locus_tag="BW153_RS03025"
                     /old_locus_tag="BW153_03015"
     CDS             21685..22413
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864241.1"
                     /locus_tag="BW153_RS03025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_03015"
                     /product="lantibiotic ABC transporter permease"
                     /protein_id="WP_058208044.1"
                     /transl_table=11
                     /translation="MKRIIASEAIKLKKSGTLRLVLIIPFVTLFIAFLMGGIQIFSVFS
                     IYWWEAGFLFLLMSLLFLYDKKSEEQAGNFQNVKWKKLSWKIHLAKMLLIWLRGILASI
                     VLIILLYLVAFVFQGIVVVDFMKASVALIAILLAASWNLPFIYLIFKWINTYVLLAANT
                     LICLIVAPFVAQTPVWFLLPYTYHYKVTESLLNIKPSGDLLTGKINFSIWEVLLPVGLS
                     IVVTIGVSYLLKGVIEHDKK"
     gene            22400..23044
                     /locus_tag="BW153_RS03030"
                     /old_locus_tag="BW153_03020"
     CDS             22400..23044
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570415.1"
                     /locus_tag="BW153_RS03030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_03020"
                     /product="transporter"
                     /protein_id="WP_017864242.1"
                     /transl_table=11
                     /translation="MIRSECLKLKNSLGFYLVFLFTLLELLTVPIYLAFGRSHVSMTDL
                     SLMIFLFFPLLVTILSILIFEQESLANHFQEINVNKKSSRIWLSKLIVVDFLLFFPSAM
                     IWIITGVSQAVGQQGMMIATASWLMAIFLNHFHLLLTFIINRGGSMIIAIIEILLIIFA
                     SNKVLLAAYWCPIALPVNFMITGRCAYLIAAVGWIVLSTIILVALSKKKIR"
     misc_feature    complement(23721..23734)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.62"
                     /tool="antismash"
     misc_feature    23787..23800
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: weak, score: 15.72"
                     /tool="antismash"
     gene            24156..24866
                     /locus_tag="BW153_RS03035"
                     /old_locus_tag="BW153_03025"
     CDS             24156..24866
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012897361.1"
                     /locus_tag="BW153_RS03035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_03025"
                     /product="EAL domain-containing protein"
                     /protein_id="WP_017864243.1"
                     /transl_table=11
                     /translation="MQDYNDLFYLIYQPIVNIKNNGTLEILEYEVLLRSQDKRRFPNKE
                     FNEILFSPEKHQMFMKWYFEKLNDILVRNKNINLAINIHPLQWKEPIIFDFFYKLKEFS
                     NRIKIELTEHRNFLEFDLDMVFKSRYAELVMLGYNFVIDDVGNGTNDIDFVIKHIEQVS
                     SIKFSILPFRDIKKETLILFIEAWFHLAKEFDKEFVVEGIECKIFSSCLLNMGIRLQQG
                     FLFGEGKSHVASSK"
     gene            24911..25966
                     /locus_tag="BW153_RS03040"
                     /old_locus_tag="BW153_03030"
     CDS             24911..25966
                     /EC_number="2.7.7.65"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012897362.1"
                     /locus_tag="BW153_RS03040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BW153_03030"
                     /product="GGDEF domain-containing protein"
                     /protein_id="WP_058221044.1"
                     /transl_table=11
                     /translation="MFISILANMSILLVSLYGYLSYYVNYNKFHSFLKDKGTFFNSIFV
                     TIVGIFLLYFAIEIGGARYDLRFLLLAFTVKYFGNKVTITSTLLLMVIRLFWGIDNHTP
                     IAICYSVLLVFTLPMLKYIVSKINSDIIQLLILNYYCLLIGNFLNAIIIKNPLRDINIY
                     LHLYVISTILVFVLYYMINDIKKMQKKATHDYLTKMKNRSEFQAKLEVLQKKKKIFSLA
                     ILDIDYFKVFNDSFNHLVGDLVLLEVSKVLLSFEGNKINCYRIGGEEFSLVFEEINFVE
                     VENKLEKIRLAVQKIDIDEMLLDGEVRGITVSIGVSHIKTFSNIENYISSADDALYKAK
                     ENGRNQLVVGK"
ORIGIN
        1 gtaactaaag attctgcaga tctcatttta ctagatgata aatttacaac gatagaaaaa
       61 tcagtttata gcggtcgtac tatctatgct aatataaaaa actttatgag acacgaactg
      121 acaacaaatg ttgctgaagt tttggccctt gtattaggtt tagttttatt tagaagtagt
      181 gttggaaatg tagcagcaat gactccgaca ttgactgctt taatggttct ttgggttaat
      241 atggtgagtg atgcgattcc atctttttct ttgggttatg atgttgccga aacagatttg
      301 atgaaagaaa aaccacggaa ccctaatgaa tctattcttg ctaaccacac gtggtctagg
      361 gttttgatta ggggaacagt tatgggagcg atggtttatc ttggatttct cctggctgct
      421 caaaatggat tgaacgctag tgaagcacaa acagttgctt ttctgacttt agtttatgga
      481 caattatggc atgtatttga tgcaagaagt tcaagaacat tgtttagacg taatcctttt
      541 gggaatatta gacttgttgg agcagtgtta tttgcaggag tttcttcatt tttagtaaca
      601 atcattccgt ttttcaatag tgtgatggga actgctcagt taacattacc tgtatatcta
      661 cttgtgattt ttattcctgc tctacctaca ttaatattgt caggaataaa agaagttttt
      721 aaaataaaaa tatggtaaat caatgcaaaa aagtacttac ttgagtaagt actttttttg
      781 taggttacta attacaaact gatgtttgtt tttgatttct aaatttgcaa tttagagtat
      841 tacctaatat gcttaaaatc atcgtaagtg ctagtttata aaggttatat cgcttttttc
      901 attgattgat attttacttt atagggttta ataataatta aaaatgaata atatgatgat
      961 atcaagtaat ttttgtaagc tttatattac aatatttctt tttgttatgt tatactgtga
     1021 taaattggtg gattgcaatc aaaaattaat gattttcgtt aattataaat ccatactaaa
     1081 ttaaagttag gagaataaca tgatttcgat acaatttagt gatgtaaagg aaaaataatt
     1141 gtaaattttg aattgagcgg tttataaccc aaattagaga aaggatttat aggagcaaaa
     1201 tttttctgct ataaatataa aaaaatgaaa cgtaattcat caatagattt aatgaaaagt
     1261 tgtgcaatat tctttgtcat ttcggtccat tttttattaa attcgggctt ttatgatatg
     1321 acaattcatt ccactttagc aattttttgg attgggataa gaacgatttt aattacttgt
     1381 gtgcccttgt ttttagtggc aactggattt ttaatgaatc gaaaagaatt aagtgctcaa
     1441 tatgttctag gaatagttcc tgtcatcatt tcatatatag gcatatcttt attagtatgg
     1501 ggagttctat ctcttgtcgg aaaaggaagc gacttctcca cagccataaa tggaattttt
     1561 gattattcaa ccgattctta ctcttggtat gttgaaatgt atttaggact ttatcttttt
     1621 atccctttat taaatattat ctggaattat aaaaaagaaa taaaaaatta tcatttatat
     1681 attgtcttta tcgcaagttt gctaacattc ttaccctctt tattaaatag ttttggaaaa
     1741 gttattccag actattggca aatttgttat cccgttagtt attattttat tggagcttac
     1801 ctttatactt atcaaaatga aataaagaaa atttcaatag gaaaacttgt tacagcattc
     1861 ttaagtgcac ttacgatttt tactttgacg gacacttttg caagttggaa tcaagaattt
     1921 cagtggctag accacaatga ttattttggt tatcaaacag ccataatgac agtattagtt
     1981 atagcaatct tgtggagaac tcccattcca aaatggagcg ttaggttgct aaaggctcta
     2041 tctaccgcta ctttgactat ctatcttata tccgatttaa cggatcagtt tgtctatgga
     2101 ttttttaagc atgaaattcc aaacttaagt caacgagtga tagcaggacc gattattatt
     2161 ccagtagcct ttactagtgc ggcattacta ggaatttttg tgggaaaagt tttaaatatc
     2221 ccttttaaga gaaaaaaaga aagaaaggaa aattaaaact atgataatct caacaatggt
     2281 agatgtttat gttgtttatt atccgattat cttgtccttc atttgggcaa gtggtgcttt
     2341 tttatctcgg tggaaagaaa gagataagaa agcaattgat gaaacaaaag aatttgaaaa
     2401 aattagtatt gttatttctg cgtacaatga agaagaaacg attgaggaag ttttattatc
     2461 actacgtaat ctaaattacc cttccctaga gatctttatt gttgatgata agagtagtga
     2521 ccgcacttta gagaaacttt atgaagtaaa aaaatctttc gacgattggg aaacattaac
     2581 tattcttgag caaaaggaaa ataagggaaa agccacggct ttaaatgttg ctttgcaaca
     2641 agttaacagt aagtatatgc ttgttattga tgcggactca tatctttcta aagatgctct
     2701 atcttattta ttggccgaat taacttctag ttcagatatt ggggctgtga ctggacgacc
     2761 tattgttaga aacagaacaa ctctattggg gaaattacaa accttagagt atttaagtgt
     2821 gattgatgcg attaagagag cacaaagtct ttttctaggt gcaataatga ccgtatcagg
     2881 tgtgattgtt atgtatcgtg tagaggcttt gaaagaaatt gggggcttta ataccgaagt
     2941 gatgacggaa gacattgatg tcacttggcg acttcatcgt aatcaatgga aagtcaaata
     3001 tgtccctaaa gccttaagct atattctcgt tcctgaaaat ttaaaatctc ttttaaagca
     3061 acggagaaga tgggcagttg gtggagtaga agtattaatt tcaaatttat catgggtttt
     3121 taaaagagga gaatttaaac atcggtttct tttgattgaa atgatttgta gtcatatttg
     3181 gagttggttt ttcttaatag aatcttatca gtattttctc caaatgctgt taaatcaaga
     3241 attcaaagta tcgggtcaaa ttatcgtgat ttttgttctt atttcatttt ttgtattctt
     3301 tttaggactt aataatgata aaggggagag tcgcttatcc ttgactgata aattaatatt
     3361 tccagcttat cttgttgctt attggtttct aaatttgatt agtgctcttt ctgctgaact
     3421 tgttgtttta actaatcgga caaataaagg aaaatgggaa agtcctgata gaggggtgta
     3481 ataatggaat tagtaatacg taaaaaaatg aaaaaacgac attttttgga attcttggct
     3541 gtttcactat gttggctgtt tatattaatt gttttcgttc ttttattaat ctctttgctg
     3601 gggatatata gtgatggaat tatctctgtt tttgtaatca ttgggtttcc aatcataaat
     3661 tgggaagata taatttatga tttgttttgt cttctttcaa tattaacgat tcctagtctt
     3721 tatattttaa cgaaggaggc ttagatttat aatatgaaat ttagtaaaaa gaatattttt
     3781 ttgatattga tgtttggtct tattgctatc ttggtgttta tgtccacacg tgaaacaaaa
     3841 aaatatgtac aagatggaaa aaaggagcag ccagattttg cttatgagag tttgcttaaa
     3901 gacaatgatg gaattattgt tctttgttat caccgtgtgt taaaagatac ggtggttaca
     3961 aatttcgctt attcaatttc gcataattct caactccatg aatataatgt attcttgcaa
     4021 gattttgaac agcaaatgac atttttaaag aaaaatcata ttaaagtttt gactagttca
     4081 gaactgatag agaagcttaa taaaaaagag gtgattggca aagcagtagt gattactttt
     4141 gatgacattg ataagtcttt gccagagaac gcttatccaa taatgaaaaa attagactta
     4201 ccctttacgc aattcattat cacgggaaaa gttggacaaa ccattgatgg ttcacaaatg
     4261 tcgacttgga aagaaataaa gaaaatgaat gaaaatcctt tgattacttc agggctgcat
     4321 acgaatgact tacattatca agaaaacttt gaaccgattt tatctactaa tatttcaaaa
     4381 aaagtagtgc aaaaagatta ccaaaaaagt cagaaagcat ttggtgagaa gttagatcaa
     4441 aaaggaaaag tttttgctta tccctatgga gcacaaaata aagacttaga agattatatg
     4501 ctacaagatg gaattcaagg aatattcaca ctatctccag gtgtagtgaa taatgaaaca
     4561 ctatatagta atattcctag gttgattgtt acgaaggata attggaaaac tatcaaacat
     4621 tggctcttaa gtgaagggac acaataataa gagaaaataa gaaggagata ttcatgaagg
     4681 cgaagaataa gtcatttaaa ttattaatgg ttctgagttt attgatgtgc ttggttggaa
     4741 ttaatttatt taaaacttca aatgtatttg ctgctgacta tggaaataaa tttataacgg
     4801 gacatgaact gactgatgat ttgggaaata cgaaaacaga ttttggtatt tatgatgatg
     4861 ttcaggctca ttgggatttt gatattccag tgggaagcgt ttctcagggg gatacaatga
     4921 gtgtcaatgt tcctgattta ttaactttat caaaagatat tacttttgaa ataaaagatg
     4981 aagctggaaa tattatcgga acggcggttg ctaatcatct tacgggggtg gtaactgtta
     5041 ctttttcaaa acttgttgaa aatgcaactt cagatattaa aggttcattt tccgtttggg
     5101 ttaattggga tgaacaaaaa gtagaggaag acacaaaggt agtagttgat tggaaagatg
     5161 gaggaacaac agaggttagc attggtccgg caacaggacc ggataaagat gaggtacttt
     5221 ataaatgggg atgggttgac gagaatgatt caaccttaat tcattggcag gttcggatca
     5281 attatgctaa agaaaatatc cagaaagcta tttatactga tattattggc gggaatcaga
     5341 atttagtttc tggttcgatt tcggtagcta atgtgactta tagtagcaat ggagagaatt
     5401 ataatgttga aagctactat cctcaagcta gtattttaga aaatggcgtg aacggattta
     5461 ccgtgaattt aggtgatatt tcaaatacga ttattgtcga ttattcaacg aaggcaacgg
     5521 atggagggct ttctcaacag tatgaaaata gaggagaatt gacgggagaa aatattgaaa
     5581 aacaggtagt ggaagttcac actcctaaca atggtggaaa tggaaatgca agtatgaaac
     5641 tttctatttc tggagagaaa acttggattg atgaaaataa tgcacgtggt ttaagaccaa
     5701 gttttattag tattgtgtta tatcggaatg gagagaaagt tgattcacga gatgtgacgg
     5761 ctaaagaaaa ttggaaatat tcgtttaccg atttggataa gtacgatgaa agtgggaaac
     5821 tttacgatta tgatgtaaaa gaggtgcctg ttagtaatta cacgagtcaa caggaggggt
     5881 ataattttat aaatacaatc atccctgtta aagaagaaac tcctgaaaaa cccgaccaat
     5941 caattactac tcctagttca tcctcacaag taatgtcggt ttcgtcttct tcaatggaat
     6001 cagaaccttc tgaagagttg cctaaaacgg gggatagccc aagggatttt ttcaaagtgt
     6061 tgggaatact tctattgatt tctgggggtc ttggaatgat ttatattagg agaaaatcaa
     6121 aaatttaatt atctgagatg atgtaaaaga aaaggagtta tcaattattt gaaactcctt
     6181 tttatatatt gtaggctctc aacttttatg aaagtgttta agacttttta tttttatata
     6241 cagtaatcgc aatttgacat aaacatccga tgataaagcc taaaaccgct ggaagaatcc
     6301 aacccattcc tagggagaaa aagggtagaa agtctttagc aaaattaatt attactgata
     6361 tgaaagtaat tgtgtgaaga ctggctggaa gagcattgag tccgtcgata atagccgcta
     6421 aaagtgtaaa agcagttgtt atctgataaa cgagtctaga atatttaaaa agtgggctta
     6481 ataaagctaa taaaataagg ataatggcta agggatataa aaacatgagg actggaactg
     6541 aaagttctat aatttttgtc aaaccaatat ttgcaaagat gcaaggaaga atacttacga
     6601 tgaggagata aaaacgatat tcttttttag gaaataattc gacaaaggtt tcagaaaagg
     6661 cagacattaa gccaacggct gtttttaagc aagcgatgat gacaatgagt gctaagataa
     6721 tcatgccgaa atttcctaag tagtggttgg aaatttgagc gagagcaatt ccaccatttt
     6781 cactaatagc aaattgccca agactcatag cacctaggta agaaaggcag gtgtaaatga
     6841 tagccattag tcctacactg atgaggccag cttttatggt ttctttagca ataattttag
     6901 gattttttac gccacgttgg cgaatagttg tgatgataat gattccaaaa gctaaggcgg
     6961 ccaaggcatc aagagtattg taaccttgtg tgaaacctgt caaaatagga gatgcttgat
     7021 agcttttacc aatttctgct tggctaactt ttcctaatgg atgagtgaaa gcaatgacca
     7081 aaataatacc taacaaaacc aaaaagaggg gatttaaaaa ttttccgata taatctaaga
     7141 gttttgttgg ctttctagac agaaaccagg cggttccaaa gaaaaggata ctaaaaagag
     7201 ccaatagtgg agcttggagt tcatgactta aaaaaggtga aattccaatt tcaaaagaag
     7261 tggttgctaa gcgaggaaga gcaaaaaagg ggccaataac gagataaagt aaaattgtaa
     7321 aaatataagc ataaatacga ttgactcggg aagctaactc aaaaaccccg ttactttgag
     7381 aaattcccag ggcgataatt cctaaaaaag gaaagccgac tgccgtaatt aaaaaaccaa
     7441 aatttgcttg tgaaatagcg gctccggctt cttgacccat atgtattgga aaaattaaat
     7501 ttcctgcacc aaagaaaagt ccgaataaca ttgaccctat aaagaggtaa tctttaccag
     7561 ctaatttttc ctccataaat actccttata attgatttgt ttgatagata aaataatgaa
     7621 ttattatagc aaaaaaattg tgaatttaca acacaatttt atagaaaaca tgacgattga
     7681 ttttattaag ccttttaaat taccaagtaa attcagagtt aaagtaaagt ttgaagaaaa
     7741 ttttttctct tgcttaattt agaatacata aaaaggaccc cgctaaaagg tcttttatat
     7801 ttaaaaatta gcttatttca aaacatcagt taattcttct ttgtgttctc tgaaatattt
     7861 gacggcataa gggcaagtgg ctcctaattt taattgttcg cgtcttgctt tttggattcc
     7921 ggcaagaact aatttttcgg ctaggccttg accgcgatag tcaagtgaaa cgccagtatg
     7981 agtgattatt attgaattat tcataggcat ataggccatt tcgccaatga cttctccttt
     8041 atctgacaga agttcaaata gattttctct ttcaataatg ttcattagtt tttctccttc
     8101 gccaaatatt ttagtgctcc ggaagggcat ctattgatta ctgattgatt ggaagcgaca
     8161 tcgccattat cggggataat ccaaggctta cggccaactt caaatactaa aggatttcct
     8221 ctaacacatt cacctgcatg ctcacaaatt gctacattgt aataaatatc catgttttca
     8281 ccacgatact tacgataatc atttttcaat agttgttctt cattcgcagc ttcgccaaat
     8341 aattttgaat tatccatttt cttcctcctg tttacgattg tattttttta tatgacattt
     8401 gtcaagctgc tttatcagaa tgatatctat agaaagcatt gaaaaataat ataggggtct
     8461 aggaagagat gaaagagata tacagatatg ttataatata aatgcttatt gacttttttg
     8521 tcttggaaaa atgaaaatat gttttagggt tgattaaata aaagtaaaat taattaatca
     8581 atgacagatt aataaaaaag agaaaaaact ctagtaataa attggaaaat tttttgctta
     8641 aaaaattacg gagaaggaat ttcaaataag ataatggaaa tttttgatac acatataaag
     8701 tgcgttttaa cctagtttta aaagatttac tgttaataaa aataaagtga accaaagaac
     8761 taaccaaagc aaaactatac agcatttact ttatccaaaa cctactgtaa aatttatagt
     8821 aggttttgta gtttaaaata ttaaagtaaa tttacaaata actcttaagt gagatagtct
     8881 aaataaatga attgatgtgc accccaaaag ttagactttt tatccaggta tttatgcttg
     8941 gattttttat tgtttaattc ccttttttgt atacaagctc gtattcttaa caaataattg
     9001 gcatatcggg tttaaaaata ctatgtgttt taaggaatct ctcatgagtt tgacgccaat
     9061 aacttagatt aaaatcaccg tcaccttatt tttaggcacg ttcggcagta accttatcaa
     9121 atgtatctca gtcattgagt ttcatgatag tatttactat tttgatggtt tttgttatta
     9181 tccaatcgtt aaaatgacaa aaacaaatag ataaatagat aaatatttat ggggaggaca
     9241 agtgaactta tcatgattaa ttgtaaacga ttgagttctg aatgtttcaa attatgagga
     9301 acaacagaag ttggactatt ctttaaaccc ctcgacaata ccatcactct tcattagcct
     9361 aaaattaaca agttaaaatc attagaataa tctcttttac aaaaaatatt tatttaagtt
     9421 atagctgacg aatatttaat aattttatta atatcttgat tttctagttc ctgaataata
     9481 tagagatagg tttattgagt cttagacata attgaatgac ctagtcttat aactatactg
     9541 acaatagaaa cattaacaaa tctaaaacag tcttaattct atcttgagaa agtattggca
     9601 ataatattat tgtcgataac gcgatcataa taaacggctc tgattaaatt ctgaagtttg
     9661 ttagatacaa tgatttcgtt cgaaggaact acaaaataaa ttataaggag gcactcaaaa
     9721 tgagtacaaa agattttaac ttggatttgg tatctgtttc gaagaaagat tcaggtgcat
     9781 caccacgcat tacaagtatt tcgctatgta cacccggttg taaaacagga gctctgatgg
     9841 gttgtaacat gaaaacagca acttgtaatt gtagtattca cgtaagcaaa taaccaaatc
     9901 aaaggatagt attttgttag ttcagacatg gatactatcc tatttttata agttatttag
     9961 ggttgctaaa tagcttataa aaataaagag aggaaaaaac atgataaaaa gttcatttaa
    10021 agctcaaccg tttttagtaa gaaatacaat attatctcca aacgataaac ggagttttac
    10081 tgaatatact caagtcattg agactgtaag taaaaataaa gtttttttgg aacagttact
    10141 actagctaat cctaaactct ataatgttat gcagaaatat aatgctggtc tgttaaagaa
    10201 gaaaagggtt aaaaaattat ttgaatctat ttacaagtat tataagagaa gttatttacg
    10261 atcaactcca tttggattat ttagtgaaac ttcaattggt gttttttcga aaagttcaca
    10321 gtacaagtta atgggaaaga ctacaaaggg tataagattg gatactcagt ggttgattcg
    10381 tctagttcat aaaatggaag tagatttctc aaaaaagtta tcatttacta gaaataatgc
    10441 gaattataag tttggagatc gagtttttca agtttatacc ataaatagta gtgagcttga
    10501 agaagtaaat attaaatata cgaatgttta tcaaattatt tctgaatttt gtgagaatga
    10561 ctatcaaaaa tatgaagata tttgtgaaac tgtaacgctt tgctatggag acgaatatag
    10621 agaactatcg gaacaatatc ttggcagtct gatagttaat cattatttga tctctaattt
    10681 acaaaaagat ttgttgtcag atttttcttg ggacactttt ttgactaaag ttgaagcaat
    10741 agatgaagat aaaaaatata taatttctct gaaaaaagtt caaaagttta ttcaagaata
    10801 ctcagaaata gaaattggtg aaggtattga gaaactgaaa gaaatatatc aggaaatgtc
    10861 acaaattctt gagaatgata attatattca aattgattta attagtgata gtgaaataaa
    10921 ttttgatgtt aaacaaaagc aacaattaga acatttagct gagtttttag gaaatacgac
    10981 aaaatctgta agaagaacat atttggatga ctataaggat aaatttatcg aaaaatatgg
    11041 tgtagatcaa gaagtacaaa taacagaatt atttgattct acatttggca taggagctcc
    11101 atataattat aatcatcctc gaaatgactt ttatgagtcc gaaccgagta ctctatacta
    11161 ttcagaagag gagagagaaa agtacctcag catgtatgta gaagccatta aaaatcataa
    11221 tgtaattaat cttgacgact tagagtctca ttaccaaaaa atggacttag aaaagaaaag
    11281 tgaacttcaa gggttagaat tatttttgaa tttggcaaag gagtatgaaa aagatatttt
    11341 tattttaggg gatatcgttg gaaataataa tttgggaggg gcatcaggta gattttctgc
    11401 actctctccg gagttaacaa gttatcatag aacgatagta gattctgtcg aaagagaaaa
    11461 tgagaataaa gaaattacat cgtgtgaaat agtatttctt ccagaaaata tcagacatgc
    11521 taacgttatg catacatcaa ttatgaggag gaaagtactt ccatttttta caagtacaag
    11581 tcacaatgaa gttcagttaa ctaatatcta tattggaata gacgaaaaag aaaaatttta
    11641 tgcacgagac atttcaactc aagaggtatt gaaattctac attacaagca tgtacaataa
    11701 aacgttattc agtaatgagc taagatttct ttacgaaatt tcattagatg acaagtttgg
    11761 taatttacct tgggaactta tttacagaga ctttgattat attccacgtt tagtatttga
    11821 cgaaatagta atatctcctg ctaaatggaa aatttgggga agggatgtaa ataataagat
    11881 gacaataaga gaacttattc aaagcaaaga aattcccaaa gagttttata ttgtcaatgg
    11941 agataataaa gtttatttat cacaggaaaa cccattggat atggaaattt tagagtcggc
    12001 gataaagaag agctcaaaaa gaaaagattt tatagagcta caagaatatt ttgaagatga
    12061 aaatatcata aataaaggac aaaaggggag agttgccgat gttgtagtgc ctttcattag
    12121 aacgagagca ttaggtaatg aagggagagc atttataaga gagaaaagag tttcggttga
    12181 acggcgtgaa aaactgccct ttaacgagtg gctttatctc aagttgtaca tttctataaa
    12241 tcgtcaaaat gaatttttac tgtcgtatct tccagatatt cagaaaatag tagcaaacct
    12301 gggtggaaat ctattcttcc taagatatac tgatcctaaa ccacatatta gattgcgtat
    12361 aaaatgttca gatttatttt tagcttacgg atctattctt gaaatcttaa aaaggagtca
    12421 gaaaaatagg ataatgtcaa cttttgatat ttctatttat gatcaagaag tagaaagata
    12481 tggtggattt gatactttag aattatccga agcaatattt tgtgccgatt ctaaaattat
    12541 tccaaatttg cttacattga taaaagatac taataatgat tggaaagtcg atgatgtatc
    12601 aatcttggtg aattatttat atctgaaatg cttctttcag aatgataaca aaaagattct
    12661 taattttttg aatttagtta gtcctaaaaa ggttaaagaa aatgtcaatg aaaagattga
    12721 acattatctt aagcttctga aagttgataa tctaggtgag caaatttttt atgacaagaa
    12781 ttttaaagaa ttaaagcatg ccataaaaaa tttattttta aaaatgatag ctcaagattt
    12841 tgaacttcag aaagtttatt caattattga cagtatcatt catgtccata ataaccgact
    12901 aattggtatt gaacgagata aagagaaatt aatttattac acacttcaaa ggttgtttgt
    12961 ttcggaagaa tacatgaaat gaggactaat agatggatga agtgaaagaa ttcacatcaa
    13021 aacaattttt taatacttta cttactcttc caagcacctt gaagttaatt tttcagttgg
    13081 aaaaacgtta tgcaatttat ttaattgtgc taaatgctat cacagctttt gttccgttgg
    13141 ctagtctttt tatttatcaa gatttaataa actctgtgct aggttcaggg agacatctta
    13201 tctatattat tatcatctat tttattgttc aagtgataac aacagttctg ggacagctgg
    13261 aaagttatgt tagtggaaaa tttgatatgc gactttctta cagtatcaat atgcgcctca
    13321 tgaggactac ctcatctctt gaattaagtg attatgagca ggctgatatg tataatatca
    13381 tagaaaaagt tactcaagac agcacttaca agccttttca gctatttaat gctatcattg
    13441 ttgtgctttc atcgtttatc tcattgctat ctagtctatt ttttattgga acatggaaca
    13501 ttggggtagc aattttactc cttattgttc cagtattatc tttggtactt tttctcagag
    13561 tgggacaatt agagttttta atccagtggc agagagcaag ttctgaaaga gaaacatggt
    13621 atattgtata tttattgact catgattttt catttaaaga aatcaaatta aataatatta
    13681 gcaattactt cattcataaa tttggaaaat taaagaaagg atttatcaac caagatttag
    13741 ctattgctcg taagaagaca tatttcaata tttttcttga tttcattttg aatttgataa
    13801 atattcttac gatatttgct atgatccttt cggtaagagc aggaaaactt cttataggta
    13861 atttggtaag tctcatacaa gctatttcta aaatcaatac ttattctcaa acaatgattc
    13921 aaaatattta catcatttat aatactagtt tgtttatgga acaacttttt gagtttttaa
    13981 agagagaaag tgtagttcac aaaaaaatag aagatactga aatatgcaat caagatatag
    14041 gaactgttaa agtaattaat ttatcatatg tttaccctaa ttcgaatgcc tttgcactaa
    14101 agaatatcaa tttatccttt gaaaaaggag aattagctgc tattgtagga aaaaatggtt
    14161 ccgggaaaag tacactagta aagataattt caggattata tcaaccaact atgggaataa
    14221 tccaatacga caaaatgaga agtagtttga tgcctgagga gttttatcag aaaaacatat
    14281 cggtgctgtt ccaagatttt gtgaagtatg agttaacgat aagagagaat ataggattga
    14341 gtgatttgtc ttctcaatgg gaagatgaga aaattattaa agtcctagat aatttaggac
    14401 tcgatttttt gaaaactaat aatcaatatg tacttgatac gcagttagga aattggtttc
    14461 aagaagggcg tcaactttca ggaggtcagt ggcaaaaaat tgcattagca aggacattct
    14521 ttaagaaagc ttcaatttat attttagatg aaccaagtgc tgcactcgat cctgtagctg
    14581 aaaaagaaat atttgattat tttgttgctc tttcggaaaa taatatttca attttcattt
    14641 ctcatagttt gaatgctgcc agaaaagcaa ataaaatcgt ggttatgaaa gatggacagg
    14701 tcgaagatgt tggaagtcat gatgtccttc tgagaagatg tcaatactat caagaacttt
    14761 attattcaga gcaatatgag gataatgatg aataaaaaaa atataaaaag aaatgttgaa
    14821 aaaattattg ctcaatggga tgagagaact agaaaaaata aagaaaactt cgatttcgga
    14881 gagttgactc tctctacagg attgcctggt ataattttaa tgttagcgga gttaaaaaat
    14941 aaagataact caaagatata tcagaaaaag atagacaatt atattgaata tattgttagc
    15001 aaactttcaa catatgggct tttaacagga tcgctttatt cgggagcagc tggcattgca
    15061 ttaagtatcc tacatttacg agaagatgac gaaaaatata agaatcttct tgacagccta
    15121 aatagatata tcgaatattt cgtcatagaa aaaattgaag gatttaattt ggaaaacatt
    15181 actcctcctg attatgacgt gattgaaggt ttatctggga tactttccta tctattatta
    15241 atcaacgacg agcaatatga tgatttgaaa atactcatta tcaatttttt atcaaatctg
    15301 actaaagaaa acaaaggact aatatcgctt tacatcaaat cagagaatca gatgtctcaa
    15361 tcagaaagtg agatgtatcc actaggctgt ttgaatatgg gattagcaca tggacttgct
    15421 ggagcgggct gtatcttagc ttatgcccac ataaaaggat atagtaatga agcctcgttg
    15481 tcagctttgc aaaaaattat ttttatttat gaaaagtttg aacttgaaag gaaaaatcag
    15541 tttctatgga aagatggact tgtagcagat gaattaaaaa aagagaaagt aattagggaa
    15601 gcaagtttca ttagagatgc atggtgctat ggaggtccag gtattagtct gctatactta
    15661 tacggaggat tagcactgga taatgactat tttgtagata aagcagaaaa aatattagag
    15721 tcagctatgc aaagaaaact tggtattgat tcatatatga tttgccatgg ctattctggt
    15781 ttaatagaaa tttgttcttt atttaagcga ctattaaata caaaaaagtt tgattcatac
    15841 atagaagaat ttaatgttaa tagtgagcaa attcttgaag aatacggaga tgaaagtggc
    15901 acgggttttc ttgaaggaat aagtggctgt atactggtat tatcgaaatt tgaatattca
    15961 attaatttta cttattggag acaagcactg ttactttttg atgatttttt gaaaggaggg
    16021 aagaggaaat gagaaaatat ttaatactta ttgtggcctt aatagggata acaggtttat
    16081 cagggtgtta tcaaacaagt caaaaaaagg tgaggtttga cgaaggaagt tatactaatt
    16141 ttatttttga taataaatcg tatttcgtaa ctgataagga gattcctcag gagaacgtta
    16201 acaattccaa agtaaaattt tataacctgt tgattgttga catgaaaagt gagaaacttt
    16261 tatcaagtag caacaaaaat agtgtgactt tggtcttaaa taatatttat gaggcttctg
    16321 acaagtcgct atgtatgggt attaacgaca gatactataa gatacttcca gaaagtgata
    16381 agggggcggt caaagctttg agattacaaa actttgatgt gacaagcgat atttctgatg
    16441 ataattttgt tattgataaa aatgattcac gaaaaattga ctatatggga aatatttaca
    16501 gtatatcgga caccaccgta tctgatgaag aattgggaga atatcaggat gttttagctg
    16561 aagtacgtgt gtttgattca gttagtggca aaagtatccc gaggtctgaa tgggggagaa
    16621 ttgataagga tggttcaaat tctaaacaga gtaggacgga atgggattat ggcgaaatcc
    16681 attctattag aggaaaatct cttactgaag catttgccgt tgagataaat gatgatttta
    16741 agcttgcaac gaaggtagga aactagagtg aaaaaaatac taggtttcct ttttatcgtt
    16801 tgttcgttgg gtttatcagc aactgtgcat ggggagacaa caaattcaca acagttactc
    16861 tcaaataata ttaatacgga attaattaat cataattcta atgcaatttt atcttcaaca
    16921 gagggatcaa cgactgattc gattaatcta ggggagcagt cacctgcagt aaaatcgaca
    16981 acaaggactg aattggatgt aactggtgct gctaaaactt tattacagac atcagctgtt
    17041 caaaaagaaa tgaaagtttc gttgcaagaa actcaagtta gttctgaatt cagtaagaga
    17101 gatagcgtta caaataaaga agcagttcca gtatctaagg atgagctact tgagcaaagt
    17161 gaagtagtcg tttcaacatc atcgattcaa aaaaataaaa tcctcgataa taagaagaat
    17221 agagctaact ttgttacttc ctctcagctt attaaggaaa aaccatcaaa ttctaaagat
    17281 gcatctggtg taattgataa ttctgcttct cctctatctt atcgtaaagc taaggaagtg
    17341 gtatctctta gacaaccttt aaaaaatcaa aaagtagagg cacaacctct attgataagt
    17401 aattcttctg aaaagaaagc aagtgtttat acaaattcac atgatttttg ggattatcag
    17461 tgggatatga aatatgtgac aaataatgga gaaagctatg cgctctacca gccctcaaag
    17521 aaaatttctg ttggaattat tgattcagga atcatggaag aacatcctga tttgtcaaat
    17581 agtttaggaa attattttaa aaatcttgtt cctaagggag ggtttgataa tgaagaacct
    17641 gatgaaactg gaaatccaag tgatattgtg gacaaaatgg gacacgggac ggaagtcgca
    17701 ggtcagatta cagcaaatgg taatatttta ggagtagcac cagggattac tgtaaatata
    17761 tacagagtat ttggtgaaaa tctttcgaaa tcggaatggg tagctagagc aataagaaga
    17821 gctgcggatg atgggaacaa ggtcatcaat ataagtgctg gacagtatct tatgatttca
    17881 ggatcgtatg atgatggaac aaatgattat caagagtatc ttaattataa gtcagcaata
    17941 aattatgcaa cagcaaaagg aagtattgtt gtcgcagctc ttggtaatga tagtttaaac
    18001 atacaagata accaaacaat gataaacttt cttaagcgtt tcagaagtat aaaggttccg
    18061 ggaaaagttg tagatgcacc gagtgtattt gaggatgtaa tagccgtagg tggaatagat
    18121 ggttatggta atatttctga ttttagtaat attggagcgg atgcaattta tgctcctgct
    18181 ggcacaacgg ccaattttaa aaaatatggg caagataaat ttgtcagtca gggttattat
    18241 ttgaaagatt ggctttttac aactactaat actggctggt accaatatgt ttatggcaac
    18301 tcatttgctg ctcctaaagt atctggggca ctggcattag tagttgataa atatggaata
    18361 aagaatccta accaactaaa aaggtttctt ctaatgaatt ctccagaagt taatgggaat
    18421 agagtattga atattgttga tttattgaat aggaaaaata aagcttttag cttagataca
    18481 gataaaggtc aggatgatgc tattaaccat aaatcgatgg agaatcttaa agagtctagg
    18541 gatacaatga aacaggaaca agataaagaa attcaaagaa atacaaataa caatttttct
    18601 atcaaaaatg attttcataa catttcaaaa gaagtaattt cagttgatta taatattaat
    18661 caaaaaatgg ctaataatcg aaattcgaga ggtgctgttt ctgtacgaag tcaagaaatt
    18721 ttacctgtta ctggagatgg agaagatttt ttacctgctt taggtatagt gtgtatctca
    18781 atccttggta tattgaaaag aaagactaaa aattgataga ttatatttct tcagaatgaa
    18841 tggtataatg aagtaatgag tactaaacaa tcggaggtaa agtggtgtat aaaattttaa
    18901 tagttgatga tgatcaggaa attttaaaat taatgaagac agcattagaa atgagaaact
    18961 atgaagttgc gacgcatcaa aacatttcac ttcccttgga tattactgat tttcagggat
    19021 ttgatttgat tttgttagat atcatgatgt caaatattga agggacagaa atttgtaaaa
    19081 ggattcgcag agaaatatca actccaatta tctttgttag tgcgaaagat acagaagagg
    19141 atattataaa cggcttaggt attggtgggg atgactatat tactaagcct tttagcctta
    19201 aacagttggt tgcaaaagtg gaagcaaata taaagcgaga ggaacgcaat aaacatgcag
    19261 ttcatgtttt ttcagagatt cgtagagatt taggaccaat tacattttat ttagaagaaa
    19321 ggcgagtctg tgtcaatggt caaacaattc cactgacttg tcgtgaatac gatattcttg
    19381 aattactatc acaacgaact tctaaagttt atacgagaga ggatatttat gatgacgtat
    19441 atgatgaata ttctaatgca ctttttcggt caatctcgga gtatatttat cagattagga
    19501 gtaagtttgc accatacgat attaatccga taaaaacggt tcggggactt gggtatcagt
    19561 ggcatgggta aaaaatattc aatgcgtcga cggatatggc aagctgtcat tgaaattatc
    19621 ataggtactt gtctacttat cctgttgtta ctgggcttga ctttctttct acgacaaatt
    19681 ggacaaatca gtggttcaga aactattcgt ttatctttag attcagataa tttaactatt
    19741 tctgatatcg aacgtgatat gaaacactac ccatatgatt atattatttt tgacaatgat
    19801 acaagtaaaa ttttgggagg acattatgtc aagtcggatg tacctagttt tgtagcttca
    19861 aaacagtctt cacataatat tacagaagga gaaattactt atacttattc aagcaataag
    19921 catttttcag ttgttttaag acaaaacagt atgccagaat ttacaaatca tacgcttcgt
    19981 tcaatttctt ataatcaatt tacttacctt ttcttttttc ttggtgaaat aatactcatt
    20041 attttttctg tctatcatct cattagagaa ttttctaaga attttcaagc cgttcaaaag
    20101 attgcattga agatggggga aataactact tttcctgaac aagaggaatc aaaaattatt
    20161 gaatttgatc aggttctgaa taacttatat tcgaaaagta aggagttagc tttccttatt
    20221 gaagcggagc gtcatgaaaa gcatgattta tccttccagg ttgctgcact ttcacatgat
    20281 gttaagacac ctttaacagt attaaaagga aatattgaac tgctagagat gactgaagta
    20341 aatgaacaac aagctgattt tattgagtca atgaaaaata gtttaactgt ttttgacaag
    20401 tattttaaca caatgattag ttatacaaaa cttttgaatg atgaaaatga ttacaaagcg
    20461 agaatctccc tggaggattt tttgatagat ttatcagttg agttggaaga gttgtcaaca
    20521 acttatcaag tggattatca gctagttaaa aaaacagatt taaccacttt ttacggaaat
    20581 acattagctt taagtcgagc acttatcaat atctttgtta atgcctgtca gtatgctaaa
    20641 gagggtgaaa aaatagttag tttgagtatt tatgatgatg aaaaatatct ctattttgaa
    20701 atctggaata atggtcatcc tttttctgaa caagcaaaaa aaaatgctgg aaaactattt
    20761 ttcacagaag atactggacg tagtgggaaa cactatggga ttggactatc ttttgctcaa
    20821 ggtgtagctt taaaacatca aggaaactta attctcagta atcctcaaaa aggtggggca
    20881 gaagttatcc taaaaataaa aaagtaattt agtaatctct aaggattact ttttttgttt
    20941 ctgaatagat tctgaaaatt gttttatata ctttttttaa acataaaata aagtgaggaa
    21001 atataatgca ggtaaaaatt caaaatcttt ctaaaacata taaagaaaag caggtgctac
    21061 aagatatcag ttttgatatt aaatctggaa cagtctgtgg tttattagga gttaacggtg
    21121 caggaaaatc aactttgatg aaaattttgt ttggtttaat ttctgcagat actggaaaaa
    21181 ttttttttga tggacaagaa aagacaaata atcaacttgg agccttaatc gaggctccag
    21241 caatatatat gaatttatct gctttcgata atcttaaaac taaggctttg ctttttggaa
    21301 tttcagataa gagaattcat gaaactctag aagtgattgg tttggcagaa acaggaaaga
    21361 aaagagcagg aaaattctct ttagggatga aacaacgttt gggaattggt atggctattc
    21421 ttacagaacc tcaattttta attcttgatg aacctactaa tggtttggat cctgatggta
    21481 ttgcggagtt gttaaactta atcttaaaac ttaaagctaa aggtgtgaca atcttgattt
    21541 ctagtcatca gttgcacgaa ataagtaaag tagctagtca aattattatt ttgaacaaag
    21601 gtaagattcg ttataatcat gcgaacaata aagaagacga cattgaacag ttattcttta
    21661 agattgtgca tggaggaatg tgatatgaaa agaataatag catcagaagc aataaaatta
    21721 aaaaaatcag gaactcttag attggtatta attatccctt ttgtgactct atttatagca
    21781 tttcttatgg gtggaataca gatttttagt gttttttcaa tttattggtg ggaagctggt
    21841 tttttattcc ttttgatgag tttgcttttt ctttatgata aaaaatcaga ggagcaagct
    21901 ggaaattttc aaaatgtgaa atggaaaaag ctgagttgga aaattcattt ggccaaaatg
    21961 ttgttgattt ggctaagagg tatactagcg agcatagtct tgattatttt gctttatttg
    22021 gttgcttttg tgtttcaagg tattgtagtg gtggatttta tgaaagcaag tgtggcattg
    22081 attgctatat tactagcagc ttcttggaat ttacccttta tatacttgat tttcaagtgg
    22141 attaatacct acgtattgtt agctgcgaat accttgattt gtttaattgt tgcccctttt
    22201 gttgcacaaa ctccagtatg gttcttgcta ccatacactt atcactataa agttacagaa
    22261 agtttgttaa atatcaaacc atcaggagat ttgttaacag ggaagataaa tttcagtatt
    22321 tgggaagttt tattaccagt tggactttcc atagttgtaa cgataggagt ttcgtattta
    22381 cttaaaggag tgatagaaca tgataagaag tgaatgtctc aaattaaaaa atagcttagg
    22441 gttttattta gtttttctct ttactttatt agagctttta acggttccta tttatttagc
    22501 ttttggaaga agtcatgttt caatgactga tttgtcgctc atgatttttt tgttttttcc
    22561 gttactggtt acaattttgt ctattctaat ctttgaacag gagagtctgg ccaatcattt
    22621 ccaagaaata aatgtaaata aaaaaagtag cagaatttgg ttatcaaagc taatagtagt
    22681 ggatttcctt ttgttctttc catcagcaat gatctggata attacgggag tttcacaggc
    22741 agtagggcaa caaggaatga tgatcgcaac agctagctgg ttgatggcaa tttttcttaa
    22801 tcattttcat cttttattga cctttataat caatcgagga gggagcatga ttatcgcgat
    22861 tattgaaata ttactcatta tttttgccag taataaagtt ttattagcag cttattggtg
    22921 tcctattgct ttacctgtta attttatgat aactgggcgg tgtgcttatc tgatagctgc
    22981 cgtagggtgg attgttttat ccacaataat tcttgtggca ttatctaaaa aaaagattag
    23041 ataaagtatt ttttcttatg gtaattcgac ctaatatgtt tttgctattt atctcttatt
    23101 tctgtctata gtaatttatt caaagtacct ttagactcat aagtttgaat aaaatttcta
    23161 tcaatatgtg acagttctta ctctaagaat aatgttttcg tcgttagttt tcttttctca
    23221 gtaatttttt ataaagtggt ttcctatcga cttacacttt tcttttggag ttattggtgt
    23281 caagctcatg agagattctt taaagtatat aacgttttta aactgatatg ccagttattt
    23341 gtgaagaata tgagtttcta tataaaagag aaaattaaac aataaaaaat ccaagtataa
    23401 atacttggat tttttattat ttttgataga catataaagt gcattttaac ctagaattaa
    23461 aagatgtatc gttgataata ataaaatgaa ccaaagcaaa actatacagc aactacttta
    23521 tcataagcct actgtaaatt tacagtaggt ttttgtagtt gaaaatatta aatcaaattt
    23581 acatataaat cttagaggca taaatattta ttattcaact agttttttca atcaatagca
    23641 tacaaactat tttattttat atcctatatt tttaagattg gaaaaatgta gcgaaagaaa
    23701 gcttaaaagt aaactctatc ttttattata aaaaatagcc agcaaaaatt tttacaatta
    23761 taatattaac aaaaagtttt cattgtggta tagactttgc cttttaatat ttttatggat
    23821 tcataaagat aaaatgttaa ataaatttta atcaagatag taaattatag gaattttttg
    23881 aaatataagt tagtagaagc caaaaatata aactaataat aaataaaatt atttaaattg
    23941 accaaaaatt tattatatta taaaaaataa ataatttaca aattggtata atacagataa
    24001 aggcttttaa aatacatagt tatagtatct atttttatag ttgtaaagta attttacaat
    24061 ttatatttta attgaaaata acaattataa taatgagcag aagttactta aatattcatc
    24121 ccaatgtaaa agtaaagata taggagaatg tgtagatgca agactataat gatttatttt
    24181 atcttattta tcaaccaata gtaaatatta aaaataatgg aacattagaa attttagaat
    24241 atgaggttct acttcgatct caggataaaa ggcgttttcc aaataaggaa tttaatgaaa
    24301 ttttattttc acctgaaaaa caccaaatgt ttatgaagtg gtattttgaa aaacttaatg
    24361 atatcttagt tagaaataaa aatattaatt tggctataaa cattcatccc ttacaatgga
    24421 aggaacctat aatttttgat tttttttata agttaaaaga gttttcaaat agaataaaaa
    24481 ttgagttaac tgaacataga aattttttag aatttgatct tgatatggta ttcaaatcaa
    24541 gatatgctga attagttatg cttggatata attttgtaat tgatgatgtc gggaatggaa
    24601 caaatgatat agactttgtc atcaaacata tagaacaagt ttctagtata aaattttcca
    24661 tattgccttt tcgagatata aaaaaagaaa ctttaatatt atttattgaa gcatggtttc
    24721 atttggcgaa agaatttgat aaggaatttg tggttgaagg tattgagtgt aaaatatttt
    24781 cctcatgctt attaaatatg gggataagac tacaacaggg atttctattt ggtgaaggta
    24841 aaagtcatgt tgcttcaagt aaataaaaag atttttttaa ttttgtattt ataaatttag
    24901 ggagtgttga atgtttatta gtattttagc aaatatgagc attttattag tttctcttta
    24961 tggttactta agctattatg tgaattataa caagtttcat tcttttttga aagacaaggg
    25021 aacttttttt aattcaattt ttgtaactat tgtagggatt tttttattgt actttgcaat
    25081 tgaaattggt ggtgctagat atgatttaag atttctttta ttagcattta ctgttaaata
    25141 ttttggaaat aaagttacta taacgagcac tctattatta atggttataa gattattttg
    25201 gggcatagat aatcatacac ctattgctat ttgttatagt gtactattgg tatttacctt
    25261 acccatgcta aaatatattg tgagtaaaat taatagtgat attattcaac tcttaatttt
    25321 gaattactac tgtttattaa ttgggaattt tttgaatgct ataattatta aaaatccact
    25381 tagggacata aatatttatc tgcatttata tgtcataagt acgatattgg tatttgtcct
    25441 ttattatatg ataaacgata taaaaaagat gcagaagaag gctactcatg attacctaac
    25501 aaaaatgaaa aatagaagtg aattccaagc taaactagaa gtattacaga aaaagaaaaa
    25561 aattttttct ttagctattt tggatattga ttattttaaa gtatttaatg actcatttaa
    25621 tcatttagtt ggtgatttag tcttattaga agtgagcaaa gttttattat cttttgaggg
    25681 aaataaaata aattgctacc gtataggagg ggaagaattt tcactcgtct ttgaagaaat
    25741 aaattttgta gaggttgaaa ataaattaga aaaaattaga ttagcagttc aaaaaataga
    25801 catcgatgaa atgctattgg atggagaagt aagaggtatt actgtttcca taggagtatc
    25861 ccatataaag acattctcaa atattgaaaa ttacatttca agtgcggatg acgctttata
    25921 taaagctaag gaaaatggaa gaaatcaatt agtggtaggt aagtaatttt attattacta
    25981 ttaaatctag tcaatttatt taaagagtaa aggaaaagct ttggaaaatc at
//
