GCF_002563165.1 - 16 region(s)

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Location: 42,229 - 52,477 nt. (total: 10,249 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene overview

Tailoring

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

CN325_RS12040: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Similar gene clusters

No matches found.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.80 out of 18.16

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.32 out of 26.06

Confidence: strong

Additional weak hits (1):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 36.53

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
MogR	Repressor of flagellar motility genes

NZ_NTSF01000011.1 - Region 2 - NRPS

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Location: 71,168 - 118,184 nt. (total: 47,017 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

CN325_RS12215: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

CN325_RS12355: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: aminotransferase glycosyltransferase

CN325_RS12200: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

CN325_RS12350: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: esterase glucanase hydrolase

CN325_RS12245: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

CN325_RS12285: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

CN325_RS12305: Pullulanase, type I

smcogs: SMCOG1297: Pullulanase, type I

CN325_RS12315: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs: SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

CN325_RS12360: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Lyases: decarboxylase

CN325_RS12290: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase

CN325_RS12295: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.72	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.61	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.72	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.61	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.60 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.07 out of 27.78

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.13 out of 29.25

Confidence: medium

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 28.23 out of 31.73

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.66 out of 25.88

Confidence: medium

Additional weak hits (6):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.02 out of 32.74

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.69 out of 31.73

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.28 out of 29.72

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.46 out of 31.73

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.36 out of 33.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.63 out of 29.65

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 71167 - 118184:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Cys)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

CN325_RS12295: X - Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (268..658): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FVMAFDISLLELESLLAGELNIYGPTETTICATV
Nearest Stachelhaus code(s):: Ala DILICALICK (44% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1305..1685): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDISFDLSVYDGNTLHSGDVSLGGATEASIWSIY
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
HexR	Glucose-responsive regulator
PsrA	Oleic acid responsive regulator
SypG	Regulator of biofilm formation and host colonization

NZ_NTSF01000012.1 - Region 1 - terpene-precursor

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Location: 207,582 - 228,472 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

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Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

CN325_RS14715: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

CN325_RS14745: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

CN325_RS14750: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

CN325_RS14745: PT_FPPS_like

Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.32 out of 25.88

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78

Confidence: medium

Additional weak hits (1):

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.40 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
PsrA	Oleic acid responsive regulator

NZ_NTSF01000013.1 - Region 1 - NRP-metallophore,NRPS

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Location: 15,679 - 67,427 nt. (total: 51,749 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CN325_RS17320: Antibiotic biosynthesis monooxygenase

smcogs: SMCOG1258: Antibiotic biosynthesis monooxygenase

CN325_RS17400: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CN325_RS17465: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

CN325_RS17470: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

CN325_RS17475: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: PPTase

CN325_RS17365: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase protease

CN325_RS17340: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

CN325_RS17385: isochorismatase

smcogs: SMCOG1027: isochorismatase

Lyases: hydratase

CN325_RS17455: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Isomerases: isomerase

CN325_RS17395: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

CN325_RS17315: Pseudouridine synthase

smcogs: SMCOG1154: Pseudouridine synthase

CN325_RS17380: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CN325_RS17390: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	1.05	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.88	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.86	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.86	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.85	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.77	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.75	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.74	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	0.80	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.75	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.74	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.99 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.56 out of 27.78

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.90 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.41 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.40 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.53 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.83 out of 27.78

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.21 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.13 out of 27.78

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 28.19

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.20 out of 32.93

Confidence: medium

Additional weak hits (7):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.54 out of 30.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.35 out of 31.73

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.05 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.49 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.83 out of 32.74

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.85 out of 36.53

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 15678 - 67427:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

CN325_RS17380: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (464..864): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FAMTFDISALELQALVGGETNLYGPTETTIWSTF
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1524..1937): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQVFGGEINMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

CN325_RS17390: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SVSLYPMSSPGGALQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PMPAQGVVNK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
FuR variant 1	Ferric Uptake Regulator
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_NTSF01000017.1 - Region 1 - NRPS

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Location: 1 - 32,989 nt. (total: 32,989 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Select a gene to view the details available for it

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NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

CN325_RS18755: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acetyltransferase aminotransferase

CN325_RS18775: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

CN325_RS18780: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Lyases: decarboxylase hydratase

CN325_RS18760: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

CN325_RS18790: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase

CN325_RS18750: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.67	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.67	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 25.69 out of 33.73

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.28 out of 29.38

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.01 out of 32.93

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.38 out of 25.88

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.86 out of 21.84

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14

Confidence: medium

Additional weak hits (5):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.31 out of 25.75

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.00 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.18 out of 29.38

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.17 out of 20.01

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.60 out of 30.98

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 32989:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu - Tyr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

CN325_RS18750: Leu - Tyr

Search NORINE for peptide: strict or relaxed

AMP-binding (477..877): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LSLAFDASIMEPLLFVGGELNAYGPTEATVCTTI
Nearest Stachelhaus code(s):: Leu DAMLVGAVCK (71% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1538..1944): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: LWRYFDSSVSESDLIMGGEVNEYGPTEATVSAMY
Nearest Stachelhaus code(s):: Lys DAEDIGTVSK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
FuR variant 1	Ferric Uptake Regulator
HipB	Bacterial antitoxin HipB
LexA variant 3	Repressor of DNA damage response
MexT	Global virulence regulator
PerR	Peroxide regulator
PsrA	Oleic acid responsive regulator

NZ_NTSF01000001.1 - Region 1 - NRPS,NRPS-like

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Location: 1 - 56,980 nt. (total: 56,980 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase aminotransferase transketolase

CN325_RS00050: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

CN325_RS00095: aminotransferase

smcogs: SMCOG1019: aminotransferase

CN325_RS00175: transketolase

smcogs: SMCOG1204: transketolase

Hydrolases: esterase hydrolase

CN325_RS00055: thioesterase

smcogs: SMCOG1004: thioesterase

CN325_RS00075: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

CN325_RS00150: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs: SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

Ligases: ligase

CN325_RS00065: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CN325_RS00085: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CN325_RS00090: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.87	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.85	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.82	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.81	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.80	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.80	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001825.4	0.79	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.79	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001166.5	0.76	NRPS	HC-toxin	Alternaria jesenskae
BGC0002071.2	0.75	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.74	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.72	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.72	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.71	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002071.2	0.71	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001166.5	0.70	NRPS	HC-toxin	Alternaria jesenskae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.03 out of 26.06

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.36 out of 27.78

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.33 out of 21.55

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.42 out of 24.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.33 out of 26.06

Confidence: medium

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 28.44 out of 33.14

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.20 out of 20.01

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06

Confidence: medium

Additional weak hits (3):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.04 out of 32.74

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.88 out of 26.12

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.99 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 56980:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Asn) + (Ser - Val - Asn - X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 54262:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Asn) + (Ser - Val - Asn - X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 14304 - 56980:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Asn) + (Ser - Val - Asn - X - X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

CN325_RS00065: Asn

Search NORINE for peptide: strict or relaxed

AMP-binding (456..849): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGDYNEYGPTETTVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

CN325_RS00085: Ser - Val - Asn - X

Search NORINE for peptide: strict or relaxed

AMP-binding (474..876): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFCSGEINLYGPTEAAIDVSY
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1518..1919): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LDTGFDASTFEGWLLVGGDINGYGPTENTTFTVC
Nearest Stachelhaus code(s):: Val DAFWLGGTFK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2560..2954): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGDYNEYGPTEATVGCMT
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3597..3984): X

nrpys: Phe, Trp, Ph-Gly, Tyr, bOH-Tyr

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: IYYAFDASIVEPQFLVAGDTNHYGPTEGTVDSIV
Nearest Stachelhaus code(s):: Gln DAVQMGCVDK (59% 8Å match)
Stachelhaus code match:: 70% (weak)

CN325_RS00090: X

AMP-binding (20..436): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FWETFDPFFRDVHIMIAGEVNMYGPTETTLAKFY
Nearest Stachelhaus code(s):: Asp DPRHLALLAK (74% 8Å match)
Stachelhaus code match:: 80% (moderate)

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
ArgR	Regulator of arginine biosynthesis genes
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 2	Zinc-responsive repressor

NZ_NTSF01000020.1 - Region 1 - terpene

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Location: 20,593 - 42,446 nt. (total: 21,854 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CN325_RS20415: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CN325_RS20420: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Lyases: lyase

CN325_RS20445: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.52	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000916.5	0.46	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000812.3	0.45	other (other)	huperzine A	Shiraia sp. slf14
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001197.5	0.42	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002138.2	0.40	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.52	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000916.5	0.46	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000812.3	0.45	other (other)	huperzine A	Shiraia sp. slf14
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001197.5	0.42	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002138.2	0.40	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

CN325_RS20405: T2TS

Domain 1 (4 - 614): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 26.42 out of 30.22

Confidence: medium

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
ClgR	Caseinolytic protease gene regulator

NZ_NTSF01000026.1 - Region 1 - lanthipeptide-class-ii

Download region SVG

Location: 1 - 21,370 nt. (total: 21,370 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

CN325_RS21820: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

CN325_RS21830: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000623.3	0.72	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000505.3	0.61	ribosomal	enterocin W α, enterocin W β	Enterococcus faecalis
BGC0000552.3	0.52	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001210.5	0.52	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000517.4	0.52	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002110.3	0.51	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0002698.2	0.51	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000497.3	0.50	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0001311.5	0.50	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000520.5	0.49	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000623.3	0.72	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000505.3	0.61	ribosomal	enterocin W α, enterocin W β	Enterococcus faecalis
BGC0000552.3	0.52	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001210.5	0.52	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000517.4	0.52	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002110.3	0.51	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0002698.2	0.51	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000497.3	0.50	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0001311.5	0.50	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000520.5	0.49	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CN325_RS21820

CN325_RS21835

Leader:

MFKLKKESISELAKESYLNQLDKNNKRLENSFGA

Core:

DCNFWNISCHLGNDGSVCTLTKECRPACW

Core with dehydrations:

DCysNFWNIDhaCysHLGNDGDhaVCysDhbLDhbKECysRPACysW

antiSMASH-DB 4.0 matches for CN325_RS21835

100.0%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide

Lanthipeptides: CN325_RS21835_lanthipeptide

1

DCNFWNISCHLGNDGSVCTLTKECRPACW

29

DCNFWNISCHLGNDGSVCTLTKECRPACW

1

DCNFWNISCHLGNDGSVCTLTKECRPACW

29

75.9%

Lanthipeptides: allorf_075467_075682_lanthipeptide

1

DCNFWNISCHLGNDGSVCTLTKECRPACW

29

DC +W++SCHLGNDGS CTL+ ECRPACW

1

DCTWWDLSCHLGNDGSTCTLSVECRPACW

29

69.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

C++WNISCHLGN G CTLTKEC+P+C

1

CDWWNISCHLGNTGQFCTLTKECQPSC

27

with 91 more sequence matches

Only the first 10 are displayed here.

69.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

C++WNISCHLGN G CTLTKEC+P C

1

CDWWNISCHLGNTGRFCTLTKECQPNC

27

63.3%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21845_lanthipeptide

Lanthipeptides: CN325_RS21845_lanthipeptide

1

DCNFWNISCHLGNDGSVCTLTKECRPAC

28

DC++WN+SCHLGNDG CT +KEC P C

1

DCSWWNVSCHLGNDGKYCTASKECMPTC

28

58.6%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide

Lanthipeptides: BALI_RS00925_lanthipeptide

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

C ++NISC LGN G CTLTKEC+ +C

1

CEWYNISCQLGNKGQWCTLTKECQRSC

27

53.1%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

C ++NISC LGN G+ CTLT EC P+C

5

CAWYNISCRLGNKGAYCTLTVECMPSC

31

51.7%

NZ_CP006058.1and 23 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide

Lanthipeptides: BAMY6639_RS13800_lanthipeptide

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

C +++ISC LGN G+ CTLT EC+ +C

1

CAWYDISCKLGNKGAWCTLTVECQSSC

27

51.7%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

4

FWNISCHLGNDGSVCTLTKECRPAC

28

+WN+S +LGN G +CTLTKEC+ C

1

WWNVSKNLGNKGRICTLTKECQSMC

25

50.0%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

3

NFWNISCHLGNDGSVCTLTKECRPAC

28

N +++S LGN G CTLTKEC+P C

4

NTFSLSDFLGNQGGWCTLTKECQPNC

29

50.0%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

3

NFWNISCHLGNDGSVCTLTKECRPAC

28

N +++S LGN G CTLTKEC+P C

4

NTFSLSDALGNSGGWCTLTKECQPNC

29

50.0%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

3

NFWNISCHLGNDGSVCTLTKECRPAC

28

N +++S LGN G CTLTKEC+P C

4

NTFSLSDALGNHGGWCTLTKECQPNC

29

50.0%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS02100_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06725_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06725_lanthipeptide

Lanthipeptides: BKP57_RS02100_lanthipeptide

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

C ++N+SCHLGNDG +CT + EC C

2

CPWYNLSCHLGNDGKICTFSHECTGGC

28

MIBiG 4.0 matches for CN325_RS21835

58.6%

Lanthipeptide: haloduracin β or haloduracin α

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

C ++NISC LGN G+ CTLT EC P+C

1

CAWYNISCRLGNKGAYCTLTVECMPSC

27

50.0%

Lanthipeptide: birimositide

3

NFWNISCHLGNDGSVCTLTKECRPAC

28

N +++S LGN+G CTLTKEC+P C

4

NTFSLSNALGNNGGWCTLTKECQPNC

29

20.5%

BGC0001155.5 (AGY49587.1):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

18

CTLTKECRPAC

28

CTL+KEC+P C

28

CTLSKECQPNC

38

with 3 more sequence matches

17.2%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

8

SCHLGNDGSVC

18

SC G VC

4

SCSFGPFTFVC

14

13.8%

Thiopeptide: GE2270

17

VCTLTKECRP

26

VC C P

5

VCGFCCSCSP

14

11.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

2

CNFWNISCH

10

CN +CH

19

CNMKTATCH

27

CN325_RS21840

Leader:

MKELKKNIESEKVLKKLTEVPDLTGG

Core:

TSTTVPCGIGSTITISIAYCPTSKCTERCGTRG

Core with dehydrations:

DhbDhaDhbDhbVPCysGIGDhaDhbIDhbIDhaIAYCysPDhbDhaKCysDhbERCysGDhbRG

antiSMASH-DB 4.0 matches for CN325_RS21840

100.0%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide

Lanthipeptides: CN325_RS21840_lanthipeptide

1

TSTTVPCGIGSTITISIAYCPTSKCTERCGTRG

33

TSTTVPCGIGSTITISIAYCPTSKCTERCGTRG

1

TSTTVPCGIGSTITISIAYCPTSKCTERCGTRG

33

52.9%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

2

STTVPCGI-GSTITISIA---YCPTSKCTERC

29

+TTVPC I G I IS A +CPT CT RC

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

48.5%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide

Lanthipeptides: BKP57_RS21840_lanthipeptide

2

STTVPCGIGSTITISIAYCPTSKCTERCGTRG

33

+TTVPC + + SIA CPT C+ +CG RG

1

TTTVPCAVAA----SIALCPTLACSSKCGERG

28

with 96 more sequence matches

Only the first 10 are displayed here.

48.5%

NZ_LT630004.1:

Lanthipeptides: BQ5796_RS18310_lanthipeptide

2

STTVPCGIGSTITISIAYCPTSKCTERC

29

+TT+PC +G T+TIS++ CPT+KCT +C

1

TTTLPC-VGITVTISVSMCPTTKCTSQC

27

45.5%

NZ_CP039292.1and 1 other:

NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide

Lanthipeptides: E4J16_RS14990_lanthipeptide

1

TSTTVPCGIGSTITISIAYCPTSKCTERC

29

T ++ PCGIG T TI CPT+ CT +C

3

TPSSWPCGIGITTTI----CPTAVCTSKC

27

42.9%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12965_lanthipeptide

Lanthipeptides: MT347_RS12965_lanthipeptide

2

STTVPCGI-GSTITISIA---YCPTSKCTERC

29

+TT PC + G TI + A +CPT CT RC

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

42.4%

NZ_CP040417.1and 2 others:

NZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptideNZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptide

Lanthipeptides: FE328_RS05340_lanthipeptide

2

STTVPCGIGSTITISIAYCPTSKCTERCGTRG

33

+T++PC T+ +S A CPT C+ +CG RG

2

TTSIPC----TVMVSAAVCPTLVCSNKCGGRG

29

40.0%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

1

TSTTVPCGIGSTITISIAYCPTSKCTERC

29

T+ P IG+TI ++ + CPT+KCT RC

7

TTPATPTIIGATIAVTASLCPTTKCTSRC

35

39.4%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00390_lanthipeptide

Lanthipeptides: CWT12_RS00390_lanthipeptide

1

TSTTVPCGIGSTITISIAYCPTSKCTERC

29

T ++ PCGIG T T+ CPT+ C+ +C

3

TPSSWPCGIGITTTV----CPTAACSSKC

27

39.4%

NZ_CP040938.1and 1 other:

NZ_CP040938.1 Lanthipeptides: B5772_RS02455_lanthipeptide

Lanthipeptides: B5772_RS02455_lanthipeptide

2

STTVPCGIGSTITISIAYCPTSKCTERCGTRG

33

+T++PC + + S A CPT C+ +CG RG

2

TTSIPCAVMA----STAICPTLVCSNKCGGRG

29

39.4%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS31015_lanthipeptide

Lanthipeptides: CN325_RS31015_lanthipeptide

18

AYCPTSKCTERCGTRG

33

A+CPTSKCT RCG+RG

1

AFCPTSKCTTRCGSRG

16

38.1%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

3

TTVPCGIG-STITISI-------AYCPTSKCTERC

29

TTVPC +G +T+ I+I CPTS C+ RC

7

TTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

36.4%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide

Lanthipeptides: PO853_RS06520_lanthipeptide

4

TVPCGIGSTITISIAYCPTSKCTERC

29

T+P I + IS CPTS CT C

6

TIPISIAVSGWISDKTCPTSVCTRAC

31

MIBiG 4.0 matches for CN325_RS21840

29.7%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

10

GSTITISIAYCPTSKCTERC

29

G + +S A+CPT+KCT RC

18

GVAVGVSAAFCPTTKCTSRC

37

21.2%

Lanthipeptide: birimositide

19

YCPTSKCTERC

29

+CPT+KCT +C

16

FCPTTKCTSKC

26

CN325_RS21845

Leader:

MFKLKKENISELAKESYLNQLDKNNTRLENSFGA

Core:

DCSWWNVSCHLGNDGKYCTASKECMPTCND

Core with dehydrations:

DCysDhaWWNVDhaCysHLGNDGKYCysDhbADhaKECysMPDhbCysND

antiSMASH-DB 4.0 matches for CN325_RS21845

100.0%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21845_lanthipeptide

Lanthipeptides: CN325_RS21845_lanthipeptide

1

DCSWWNVSCHLGNDGKYCTASKECMPTCND

30

DCSWWNVSCHLGNDGKYCTASKECMPTCND

1

DCSWWNVSCHLGNDGKYCTASKECMPTCND

30

64.5%

NZ_CP102975.1and 1 other:

NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07805_lanthipeptide

Lanthipeptides: NW953_RS00170_lanthipeptide

1

DCSWWNVSCHLGNDGKYCTASKECMPTCN

29

CSWWN+SCHLGN+GK CT S EC CN

2

KCSWWNLSCHLGNNGKLCTVSHECAAGCN

30

63.3%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS02100_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06725_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06725_lanthipeptide

Lanthipeptides: BKP57_RS02100_lanthipeptide

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

C W+N+SCHLGNDGK CT S EC CN

2

CPWYNLSCHLGNDGKICTFSHECTGGCN

29

with 101 more sequence matches

Only the first 10 are displayed here.

63.3%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

C WWN+SCHLGN G++CT +KEC P+CN

1

CDWWNISCHLGNTGQFCTLTKECQPSCN

28

63.3%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

C WWN+SCHLGN G++CT +KEC P CN

1

CDWWNISCHLGNTGRFCTLTKECQPNCN

28

63.3%

Lanthipeptides: allorf_075467_075682_lanthipeptide

1

DCSWWNVSCHLGNDGKYCTASKECMPTC

28

DC+WW++SCHLGNDG CT S EC P C

1

DCTWWDLSCHLGNDGSTCTLSVECRPAC

28

63.3%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide

Lanthipeptides: CN325_RS21835_lanthipeptide

1

DCSWWNVSCHLGNDGKYCTASKECMPTC

28

DC++WN+SCHLGNDG CT +KEC P C

1

DCNFWNISCHLGNDGSVCTLTKECRPAC

28

56.2%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

C+W+N+SC LGN G YCT + ECMP+CN

5

CAWYNISCRLGNKGAYCTLTVECMPSCN

32

53.3%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

4

WWNVSCHLGNDGKYCTASKECMPTCN

29

WWNVS +LGN G+ CT +KEC CN

1

WWNVSKNLGNKGRICTLTKECQSMCN

26

50.0%

NC_018499.1and 10 others:

NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27860_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25275_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25270_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27570_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27565_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27560_lanthipeptide

Lanthipeptides: BCK_RS27860_lanthipeptide

1

DCSWWNVSCHLGNDGKYCTASKECMPTCN

29

D + +S LGN G YCT +KECMP+CN

4

DVTPEGLSSWLGNKGGYCTLTKECMPSCN

32

50.0%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide

Lanthipeptides: BALI_RS00925_lanthipeptide

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

C W+N+SC LGN G++CT +KEC +C

1

CEWYNISCQLGNKGQWCTLTKECQRSCK

28

50.0%

NZ_CP015591.1and 19 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27560_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29375_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29370_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29365_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptideNZ_JACYOF010000027.1 Lanthipeptides: IGI01_RS29005_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29780_lanthipeptideNZ_NVJC01000007.1 Lanthipeptides: COM38_RS07400_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptide

Lanthipeptides: A7A70_RS27565_lanthipeptide

1

DCSWWNVSCHLGNDGKYCTASKECMPTCN

29

D + +S LGN+G YCT +KECMP+CN

4

DVTPEGLSSWLGNNGGYCTLTKECMPSCN

32

50.0%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide

Lanthipeptides: IM743_RS02795_lanthipeptide

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

C+W++VSC LGN G +CT + EC CN

1

CAWYDVSCRLGNKGAWCTLTVECQNNCN

28

MIBiG 4.0 matches for CN325_RS21845

60.0%

Lanthipeptide: haloduracin β or haloduracin α

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

C+W+N+SC LGN G YCT + ECMP+CN

1

CAWYNISCRLGNKGAYCTLTVECMPSCN

28

43.3%

Lanthipeptide: birimositide

5

WNVSCHLGNDGKYCTASKECMPTCN

29

+++S LGN+G +CT +KEC P CN

6

FSLSNALGNNGGWCTLTKECQPNCN

30

23.1%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

18

CTASKECMPTCN

29

CT SKEC P CN

28

CTLSKECQPNCN

39

CN325_RS31015

Leader:

MKELKKNIESEKVLKKLTESPDLSGGTTIPCGELAVVITA

Core:

AFCPTSKCTTRCGSRG

Core with dehydrations:

AFCysPDhbDhaKCysDhbDhbRCysGDhaRG

antiSMASH-DB 4.0 matches for CN325_RS31015

100.0%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS31015_lanthipeptide

Lanthipeptides: CN325_RS31015_lanthipeptide

1

AFCPTSKCTTRCGSRG

16

AFCPTSKCTTRCGSRG

1

AFCPTSKCTTRCGSRG

16

56.2%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS35800_lanthipeptide

Lanthipeptides: TNCT1_RS35800_lanthipeptide

1

AFCPTSKCTTRC

12

AFCPT+KCT+ C

2

AFCPTTKCTSAC

13

50.0%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28640_lanthipeptide

Lanthipeptides: IE257_RS28640_lanthipeptide

3

CPTSKCTTRC

12

CPTS CT RC

1

CPTSGCTGRC

10

with 79 more sequence matches

Only the first 10 are displayed here.

43.8%

NZ_CP061033.1and 1 other:

NZ_CP061033.1 Lanthipeptides: IAU67_RS09325_lanthipeptide

Lanthipeptides: IAU67_RS09325_lanthipeptide

3

CPTSKCTTRC

12

CPTS CT C

7

CPTSGCTHSC

16

43.8%

NZ_GG657754.1and 1 other:

NZ_GG657754.1 Lanthipeptides: SSOG_RS27835_lanthipeptide

Lanthipeptides: SSOG_RS27835_lanthipeptide

3

CPTSKCTTRC

12

CPTS CT++C

1

CPTSGCTSKC

10

41.2%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS08060_lanthipeptide

Lanthipeptides: DEI99_RS08060_lanthipeptide

2

FCPTSKCTTRC

12

FCPT CT++C

7

FCPTGACTSKC

17

39.4%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide

Lanthipeptides: CN325_RS21840_lanthipeptide

1

AFCPTSKCTTRCGSRG

16

A+CPTSKCT RCG+RG

18

AYCPTSKCTERCGTRG

33

33.3%

NZ_CP115450.1and 1 other:

NZ_CP115450.1 Lanthipeptides: O1G21_RS35405_lanthipeptide

Lanthipeptides: O1G21_RS35405_lanthipeptide

3

CPTSKCTTRC

12

CPT+ CT+RC

12

CPTTACTSRC

21

33.3%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide

Lanthipeptides: EL241_RS13590_lanthipeptide

1

AFCPTSKCTTRC

12

A CPT+KCT++C

12

ALCPTAKCTSKC

23

32.1%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide

Lanthipeptides: BKP57_RS21840_lanthipeptide

1

AFCPTSKCTTRCGSRG

16

A CPT C+++CG RG

13

ALCPTLACSSKCGERG

28

31.0%

NZ_CP040417.1and 2 others:

NZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptideNZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptide

Lanthipeptides: FE328_RS05340_lanthipeptide

1

AFCPTSKCTTRCGSRG

16

A CPT C+ +CG RG

14

AVCPTLVCSNKCGGRG

29

31.0%

NZ_CP040938.1and 1 other:

NZ_CP040938.1 Lanthipeptides: B5772_RS02455_lanthipeptide

Lanthipeptides: B5772_RS02455_lanthipeptide

1

AFCPTSKCTTRCGSRG

16

A CPT C+ +CG RG

14

AICPTLVCSNKCGGRG

29

30.4%

NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14310_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide

Lanthipeptides: HBA49_RS00775_lanthipeptide

1

AFCPTSKCTTRC

12

A CPT++C+ RC

12

ALCPTTRCSRRC

23

MIBiG 4.0 matches for CN325_RS31015

30.8%

Lanthipeptide: birimositide

2

FCPTSKCTTRC

12

FCPT+KCT++C

16

FCPTTKCTSKC

26

27.0%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

1

AFCPTSKCTTRC

12

AFCPT+KCT+RC

26

AFCPTTKCTSRC

37

Lanthipeptide(s) for CN325_RS21830

CN325_RS21835

Leader:

MFKLKKESISELAKESYLNQLDKNNKRLENSFGA

Core:

DCNFWNISCHLGNDGSVCTLTKECRPACW

Core with dehydrations:

DCysNFWNIDhaCysHLGNDGDhaVCysDhbLDhbKECysRPACysW

antiSMASH-DB 4.0 matches for CN325_RS21835

100.0%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide

Lanthipeptides: CN325_RS21835_lanthipeptide

1

DCNFWNISCHLGNDGSVCTLTKECRPACW

29

DCNFWNISCHLGNDGSVCTLTKECRPACW

1

DCNFWNISCHLGNDGSVCTLTKECRPACW

29

75.9%

Lanthipeptides: allorf_075467_075682_lanthipeptide

1

DCNFWNISCHLGNDGSVCTLTKECRPACW

29

DC +W++SCHLGNDGS CTL+ ECRPACW

1

DCTWWDLSCHLGNDGSTCTLSVECRPACW

29

69.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

C++WNISCHLGN G CTLTKEC+P+C

1

CDWWNISCHLGNTGQFCTLTKECQPSC

27

with 91 more sequence matches

Only the first 10 are displayed here.

69.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

C++WNISCHLGN G CTLTKEC+P C

1

CDWWNISCHLGNTGRFCTLTKECQPNC

27

63.3%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21845_lanthipeptide

Lanthipeptides: CN325_RS21845_lanthipeptide

1

DCNFWNISCHLGNDGSVCTLTKECRPAC

28

DC++WN+SCHLGNDG CT +KEC P C

1

DCSWWNVSCHLGNDGKYCTASKECMPTC

28

58.6%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide

Lanthipeptides: BALI_RS00925_lanthipeptide

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

C ++NISC LGN G CTLTKEC+ +C

1

CEWYNISCQLGNKGQWCTLTKECQRSC

27

53.1%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

C ++NISC LGN G+ CTLT EC P+C

5

CAWYNISCRLGNKGAYCTLTVECMPSC

31

51.7%

NZ_CP006058.1and 23 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide

Lanthipeptides: BAMY6639_RS13800_lanthipeptide

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

C +++ISC LGN G+ CTLT EC+ +C

1

CAWYDISCKLGNKGAWCTLTVECQSSC

27

51.7%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

4

FWNISCHLGNDGSVCTLTKECRPAC

28

+WN+S +LGN G +CTLTKEC+ C

1

WWNVSKNLGNKGRICTLTKECQSMC

25

50.0%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

3

NFWNISCHLGNDGSVCTLTKECRPAC

28

N +++S LGN G CTLTKEC+P C

4

NTFSLSDFLGNQGGWCTLTKECQPNC

29

50.0%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

3

NFWNISCHLGNDGSVCTLTKECRPAC

28

N +++S LGN G CTLTKEC+P C

4

NTFSLSDALGNSGGWCTLTKECQPNC

29

50.0%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

3

NFWNISCHLGNDGSVCTLTKECRPAC

28

N +++S LGN G CTLTKEC+P C

4

NTFSLSDALGNHGGWCTLTKECQPNC

29

50.0%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS02100_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06725_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06725_lanthipeptide

Lanthipeptides: BKP57_RS02100_lanthipeptide

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

C ++N+SCHLGNDG +CT + EC C

2

CPWYNLSCHLGNDGKICTFSHECTGGC

28

MIBiG 4.0 matches for CN325_RS21835

58.6%

Lanthipeptide: haloduracin β or haloduracin α

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

C ++NISC LGN G+ CTLT EC P+C

1

CAWYNISCRLGNKGAYCTLTVECMPSC

27

50.0%

Lanthipeptide: birimositide

3

NFWNISCHLGNDGSVCTLTKECRPAC

28

N +++S LGN+G CTLTKEC+P C

4

NTFSLSNALGNNGGWCTLTKECQPNC

29

20.5%

BGC0001155.5 (AGY49587.1):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

18

CTLTKECRPAC

28

CTL+KEC+P C

28

CTLSKECQPNC

38

with 3 more sequence matches

17.2%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

8

SCHLGNDGSVC

18

SC G VC

4

SCSFGPFTFVC

14

13.8%

Thiopeptide: GE2270

17

VCTLTKECRP

26

VC C P

5

VCGFCCSCSP

14

11.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

2

CNFWNISCH

10

CN +CH

19

CNMKTATCH

27

CN325_RS21840

Leader:

MKELKKNIESEKVLKKLTEVPDLTGG

Core:

TSTTVPCGIGSTITISIAYCPTSKCTERCGTRG

Core with dehydrations:

DhbDhaDhbDhbVPCysGIGDhaDhbIDhbIDhaIAYCysPDhbDhaKCysDhbERCysGDhbRG

antiSMASH-DB 4.0 matches for CN325_RS21840

100.0%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide

Lanthipeptides: CN325_RS21840_lanthipeptide

1

TSTTVPCGIGSTITISIAYCPTSKCTERCGTRG

33

TSTTVPCGIGSTITISIAYCPTSKCTERCGTRG

1

TSTTVPCGIGSTITISIAYCPTSKCTERCGTRG

33

52.9%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

2

STTVPCGI-GSTITISIA---YCPTSKCTERC

29

+TTVPC I G I IS A +CPT CT RC

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

48.5%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide

Lanthipeptides: BKP57_RS21840_lanthipeptide

2

STTVPCGIGSTITISIAYCPTSKCTERCGTRG

33

+TTVPC + + SIA CPT C+ +CG RG

1

TTTVPCAVAA----SIALCPTLACSSKCGERG

28

with 96 more sequence matches

Only the first 10 are displayed here.

48.5%

NZ_LT630004.1:

Lanthipeptides: BQ5796_RS18310_lanthipeptide

2

STTVPCGIGSTITISIAYCPTSKCTERC

29

+TT+PC +G T+TIS++ CPT+KCT +C

1

TTTLPC-VGITVTISVSMCPTTKCTSQC

27

45.5%

NZ_CP039292.1and 1 other:

NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide

Lanthipeptides: E4J16_RS14990_lanthipeptide

1

TSTTVPCGIGSTITISIAYCPTSKCTERC

29

T ++ PCGIG T TI CPT+ CT +C

3

TPSSWPCGIGITTTI----CPTAVCTSKC

27

42.9%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12965_lanthipeptide

Lanthipeptides: MT347_RS12965_lanthipeptide

2

STTVPCGI-GSTITISIA---YCPTSKCTERC

29

+TT PC + G TI + A +CPT CT RC

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

42.4%

NZ_CP040417.1and 2 others:

NZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptideNZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptide

Lanthipeptides: FE328_RS05340_lanthipeptide

2

STTVPCGIGSTITISIAYCPTSKCTERCGTRG

33

+T++PC T+ +S A CPT C+ +CG RG

2

TTSIPC----TVMVSAAVCPTLVCSNKCGGRG

29

40.0%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

1

TSTTVPCGIGSTITISIAYCPTSKCTERC

29

T+ P IG+TI ++ + CPT+KCT RC

7

TTPATPTIIGATIAVTASLCPTTKCTSRC

35

39.4%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00390_lanthipeptide

Lanthipeptides: CWT12_RS00390_lanthipeptide

1

TSTTVPCGIGSTITISIAYCPTSKCTERC

29

T ++ PCGIG T T+ CPT+ C+ +C

3

TPSSWPCGIGITTTV----CPTAACSSKC

27

39.4%

NZ_CP040938.1and 1 other:

NZ_CP040938.1 Lanthipeptides: B5772_RS02455_lanthipeptide

Lanthipeptides: B5772_RS02455_lanthipeptide

2

STTVPCGIGSTITISIAYCPTSKCTERCGTRG

33

+T++PC + + S A CPT C+ +CG RG

2

TTSIPCAVMA----STAICPTLVCSNKCGGRG

29

39.4%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS31015_lanthipeptide

Lanthipeptides: CN325_RS31015_lanthipeptide

18

AYCPTSKCTERCGTRG

33

A+CPTSKCT RCG+RG

1

AFCPTSKCTTRCGSRG

16

38.1%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

3

TTVPCGIG-STITISI-------AYCPTSKCTERC

29

TTVPC +G +T+ I+I CPTS C+ RC

7

TTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

36.4%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide

Lanthipeptides: PO853_RS06520_lanthipeptide

4

TVPCGIGSTITISIAYCPTSKCTERC

29

T+P I + IS CPTS CT C

6

TIPISIAVSGWISDKTCPTSVCTRAC

31

MIBiG 4.0 matches for CN325_RS21840

29.7%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

10

GSTITISIAYCPTSKCTERC

29

G + +S A+CPT+KCT RC

18

GVAVGVSAAFCPTTKCTSRC

37

21.2%

Lanthipeptide: birimositide

19

YCPTSKCTERC

29

+CPT+KCT +C

16

FCPTTKCTSKC

26

CN325_RS21845

Leader:

MFKLKKENISELAKESYLNQLDKNNTRLENSFGA

Core:

DCSWWNVSCHLGNDGKYCTASKECMPTCND

Core with dehydrations:

DCysDhaWWNVDhaCysHLGNDGKYCysDhbADhaKECysMPDhbCysND

antiSMASH-DB 4.0 matches for CN325_RS21845

100.0%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21845_lanthipeptide

Lanthipeptides: CN325_RS21845_lanthipeptide

1

DCSWWNVSCHLGNDGKYCTASKECMPTCND

30

DCSWWNVSCHLGNDGKYCTASKECMPTCND

1

DCSWWNVSCHLGNDGKYCTASKECMPTCND

30

64.5%

NZ_CP102975.1and 1 other:

NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07805_lanthipeptide

Lanthipeptides: NW953_RS00170_lanthipeptide

1

DCSWWNVSCHLGNDGKYCTASKECMPTCN

29

CSWWN+SCHLGN+GK CT S EC CN

2

KCSWWNLSCHLGNNGKLCTVSHECAAGCN

30

63.3%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS02100_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06725_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06725_lanthipeptide

Lanthipeptides: BKP57_RS02100_lanthipeptide

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

C W+N+SCHLGNDGK CT S EC CN

2

CPWYNLSCHLGNDGKICTFSHECTGGCN

29

with 101 more sequence matches

Only the first 10 are displayed here.

63.3%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

C WWN+SCHLGN G++CT +KEC P+CN

1

CDWWNISCHLGNTGQFCTLTKECQPSCN

28

63.3%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

C WWN+SCHLGN G++CT +KEC P CN

1

CDWWNISCHLGNTGRFCTLTKECQPNCN

28

63.3%

Lanthipeptides: allorf_075467_075682_lanthipeptide

1

DCSWWNVSCHLGNDGKYCTASKECMPTC

28

DC+WW++SCHLGNDG CT S EC P C

1

DCTWWDLSCHLGNDGSTCTLSVECRPAC

28

63.3%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide

Lanthipeptides: CN325_RS21835_lanthipeptide

1

DCSWWNVSCHLGNDGKYCTASKECMPTC

28

DC++WN+SCHLGNDG CT +KEC P C

1

DCNFWNISCHLGNDGSVCTLTKECRPAC

28

56.2%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

C+W+N+SC LGN G YCT + ECMP+CN

5

CAWYNISCRLGNKGAYCTLTVECMPSCN

32

53.3%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

4

WWNVSCHLGNDGKYCTASKECMPTCN

29

WWNVS +LGN G+ CT +KEC CN

1

WWNVSKNLGNKGRICTLTKECQSMCN

26

50.0%

NC_018499.1and 10 others:

NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27860_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25275_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25270_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27570_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27565_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27560_lanthipeptide

Lanthipeptides: BCK_RS27860_lanthipeptide

1

DCSWWNVSCHLGNDGKYCTASKECMPTCN

29

D + +S LGN G YCT +KECMP+CN

4

DVTPEGLSSWLGNKGGYCTLTKECMPSCN

32

50.0%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide

Lanthipeptides: BALI_RS00925_lanthipeptide

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

C W+N+SC LGN G++CT +KEC +C

1

CEWYNISCQLGNKGQWCTLTKECQRSCK

28

50.0%

NZ_CP015591.1and 19 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27560_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29375_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29370_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29365_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptideNZ_JACYOF010000027.1 Lanthipeptides: IGI01_RS29005_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29780_lanthipeptideNZ_NVJC01000007.1 Lanthipeptides: COM38_RS07400_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptide

Lanthipeptides: A7A70_RS27565_lanthipeptide

1

DCSWWNVSCHLGNDGKYCTASKECMPTCN

29

D + +S LGN+G YCT +KECMP+CN

4

DVTPEGLSSWLGNNGGYCTLTKECMPSCN

32

50.0%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide

Lanthipeptides: IM743_RS02795_lanthipeptide

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

C+W++VSC LGN G +CT + EC CN

1

CAWYDVSCRLGNKGAWCTLTVECQNNCN

28

MIBiG 4.0 matches for CN325_RS21845

60.0%

Lanthipeptide: haloduracin β or haloduracin α

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

C+W+N+SC LGN G YCT + ECMP+CN

1

CAWYNISCRLGNKGAYCTLTVECMPSCN

28

43.3%

Lanthipeptide: birimositide

5

WNVSCHLGNDGKYCTASKECMPTCN

29

+++S LGN+G +CT +KEC P CN

6

FSLSNALGNNGGWCTLTKECQPNCN

30

23.1%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

18

CTASKECMPTCN

29

CT SKEC P CN

28

CTLSKECQPNCN

39

CN325_RS31015

Leader:

MKELKKNIESEKVLKKLTESPDLSGGTTIPCGELAVVITA

Core:

AFCPTSKCTTRCGSRG

Core with dehydrations:

AFCysPDhbDhaKCysDhbDhbRCysGDhaRG

antiSMASH-DB 4.0 matches for CN325_RS31015

100.0%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS31015_lanthipeptide

Lanthipeptides: CN325_RS31015_lanthipeptide

1

AFCPTSKCTTRCGSRG

16

AFCPTSKCTTRCGSRG

1

AFCPTSKCTTRCGSRG

16

56.2%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS35800_lanthipeptide

Lanthipeptides: TNCT1_RS35800_lanthipeptide

1

AFCPTSKCTTRC

12

AFCPT+KCT+ C

2

AFCPTTKCTSAC

13

50.0%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28640_lanthipeptide

Lanthipeptides: IE257_RS28640_lanthipeptide

3

CPTSKCTTRC

12

CPTS CT RC

1

CPTSGCTGRC

10

with 79 more sequence matches

Only the first 10 are displayed here.

43.8%

NZ_CP061033.1and 1 other:

NZ_CP061033.1 Lanthipeptides: IAU67_RS09325_lanthipeptide

Lanthipeptides: IAU67_RS09325_lanthipeptide

3

CPTSKCTTRC

12

CPTS CT C

7

CPTSGCTHSC

16

43.8%

NZ_GG657754.1and 1 other:

NZ_GG657754.1 Lanthipeptides: SSOG_RS27835_lanthipeptide

Lanthipeptides: SSOG_RS27835_lanthipeptide

3

CPTSKCTTRC

12

CPTS CT++C

1

CPTSGCTSKC

10

41.2%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS08060_lanthipeptide

Lanthipeptides: DEI99_RS08060_lanthipeptide

2

FCPTSKCTTRC

12

FCPT CT++C

7

FCPTGACTSKC

17

39.4%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide

Lanthipeptides: CN325_RS21840_lanthipeptide

1

AFCPTSKCTTRCGSRG

16

A+CPTSKCT RCG+RG

18

AYCPTSKCTERCGTRG

33

33.3%

NZ_CP115450.1and 1 other:

NZ_CP115450.1 Lanthipeptides: O1G21_RS35405_lanthipeptide

Lanthipeptides: O1G21_RS35405_lanthipeptide

3

CPTSKCTTRC

12

CPT+ CT+RC

12

CPTTACTSRC

21

33.3%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide

Lanthipeptides: EL241_RS13590_lanthipeptide

1

AFCPTSKCTTRC

12

A CPT+KCT++C

12

ALCPTAKCTSKC

23

32.1%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide

Lanthipeptides: BKP57_RS21840_lanthipeptide

1

AFCPTSKCTTRCGSRG

16

A CPT C+++CG RG

13

ALCPTLACSSKCGERG

28

31.0%

NZ_CP040417.1and 2 others:

NZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptideNZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptide

Lanthipeptides: FE328_RS05340_lanthipeptide

1

AFCPTSKCTTRCGSRG

16

A CPT C+ +CG RG

14

AVCPTLVCSNKCGGRG

29

31.0%

NZ_CP040938.1and 1 other:

NZ_CP040938.1 Lanthipeptides: B5772_RS02455_lanthipeptide

Lanthipeptides: B5772_RS02455_lanthipeptide

1

AFCPTSKCTTRCGSRG

16

A CPT C+ +CG RG

14

AICPTLVCSNKCGGRG

29

30.4%

NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14310_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide

Lanthipeptides: HBA49_RS00775_lanthipeptide

1

AFCPTSKCTTRC

12

A CPT++C+ RC

12

ALCPTTRCSRRC

23

MIBiG 4.0 matches for CN325_RS31015

30.8%

Lanthipeptide: birimositide

2

FCPTSKCTTRC

12

FCPT+KCT++C

16

FCPTTKCTSKC

26

27.0%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

1

AFCPTSKCTTRC

12

AFCPT+KCT+RC

26

AFCPTTKCTSRC

37

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.83 out of 21.55

Confidence: medium

Lanthipeptides

TFBS Finder

Core peptide predictions

CN325_RS21835 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3199.4 Da

Molecular weight: 3201.6 Da

Number of bridges: 4

CN325_RS21840 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 3147.6 Da

Molecular weight: 3149.6 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3167.6 Da N = 1; 3185.6 Da N = 2; 3203.7 Da N = 3; 3221.7 Da N = 4; 3239.7 Da N = 5; 3257.7 Da N = 6; 3275.7 Da N = 7; 3293.8 Da N = 8

CN325_RS21845 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3276.3 Da

Molecular weight: 3278.6 Da

Number of bridges: 5

CN325_RS31015 - Class II

Cleavage pHMM score: -2.40

RODEO score: 0

Monoisotopic mass: 1583.7 Da

Molecular weight: 1584.8 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 1602.8 Da N = 1; 1620.9 Da N = 2

CN325_RS21835 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3199.4 Da

Molecular weight: 3201.6 Da

Number of bridges: 4

CN325_RS21840 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 3147.6 Da

Molecular weight: 3149.6 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3167.6 Da N = 1; 3185.6 Da N = 2; 3203.7 Da N = 3; 3221.7 Da N = 4; 3239.7 Da N = 5; 3257.7 Da N = 6; 3275.7 Da N = 7; 3293.8 Da N = 8

CN325_RS21845 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3276.3 Da

Molecular weight: 3278.6 Da

Number of bridges: 5

CN325_RS31015 - Class II

Cleavage pHMM score: -2.40

RODEO score: 0

Monoisotopic mass: 1583.7 Da

Molecular weight: 1584.8 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 1602.8 Da N = 1; 1620.9 Da N = 2

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation

NZ_NTSF01000027.1 - Region 1 - NRPS,T1PKS

Download region SVG

Location: 50,105 - 113,525 nt. (total: 63,421 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase

CN325_RS22395: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase hydrolase

CN325_RS22385: thioesterase

smcogs: SMCOG1004: thioesterase

CN325_RS22415: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Ligases: ligase synthase

CN325_RS22420: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CN325_RS22425: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CN325_RS22430: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CN325_RS22435: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CN325_RS22445: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.89	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.88	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.86	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.85	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.84	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.83	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.82	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001249.5	0.81	NRPS	dimethylcoprogen	Alternaria alternata
BGC0002071.2	0.80	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001166.5	0.77	NRPS	HC-toxin	Alternaria jesenskae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.75	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.74	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.74	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.73	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001249.5	0.72	NRPS	dimethylcoprogen	Alternaria alternata
BGC0002071.2	0.72	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001166.5	0.71	NRPS	HC-toxin	Alternaria jesenskae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.32 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.76 out of 21.55

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.67 out of 20.01

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.37 out of 23.79

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.11 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.41 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.47 out of 27.78

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.93 out of 29.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.26 out of 28.19

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.74 out of 24.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.33 out of 24.78

Confidence: medium

Additional weak hits (9):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.27 out of 36.53

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.15 out of 26.85

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.35 out of 31.73

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.72 out of 32.93

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.77 out of 29.38

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.98 out of 33.14

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.72 out of 32.93

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.19 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 50104 - 113525:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Val - Ala) + (X - X) + (mal) + (X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

CN325_RS22420: X - Val

Search NORINE for peptide: strict or relaxed

AMP-binding (26..429): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GWLAFDLSVWEWYFFAIGEINLYGPTEATVHVSF
Nearest Stachelhaus code(s):: Thr DLWQLGLVHK (35% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1072..1464): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LNTGFDATTFEGWLIVGGDINGYGPTENTTFSTT
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

CN325_RS22425: Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (273..672): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: IALTFDVSVSEGNFMVAGEDNLYGPTEITIYATN
Nearest Stachelhaus code(s):: Ala DVSNMAIIYK (71% 8Å match)
Stachelhaus code match:: 90% (moderate)

CN325_RS22430: X - X

AMP-binding (485..892): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LWYTFDMTQKSASCFLGGEVNTYGPTECTDITVF
Nearest Stachelhaus code(s):: Dhpg DALSVGTVIK (50% 8Å match); Lys DAESVGTIIK (44% 8Å match)
Stachelhaus code match:: 60% (weak)

AMP-binding (1564..1974): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FWQTFDVVLRDLHTFFAGEVNLYGPTETTLAKCY
Nearest Stachelhaus code(s):: Asp DVRHFALMAK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

CN325_RS22435: mal

PKS_AT (535..824): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 162.3
inactive: 124.4
Methoxymalonyl-CoA: 57.1
Methylmalonyl-CoA: 45.6
Propionyl-CoA: 43.6
fatty_acid: 25.1
CHC-CoA: 18.9
Benzoyl-CoA: 15.6
Acetyl-CoA: 15.6
Isobutyryl-CoA: 15.2
2-Methylbutyryl-CoA: 12.4
trans-1,2-CPDA: 0.0
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

CN325_RS22445: X

AMP-binding (481..887): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: HNITFDVAVQEPNTIVGGEINDYGLTETTITATM
Nearest Stachelhaus code(s):: Arg DVENVGAITK (65% 8Å match); Orn DVWNIGLIHK (47% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
ArgR	Regulator of arginine biosynthesis genes
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
SypG	Regulator of biofilm formation and host colonization
ZuR variant 1	Zinc-responsive repressor

NZ_NTSF01000029.1 - Region 1 - NRPS

Download region SVG

Location: 32,376 - 98,290 nt. (total: 65,915 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase acetyltransferase acyltransferase

CN325_RS22985: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

CN325_RS22995: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

CN325_RS23025: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: deacetylase esterase

CN325_RS22945: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

CN325_RS23030: thioesterase

smcogs: SMCOG1004: thioesterase

Isomerases: mutase

CN325_RS22915: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: ligase

CN325_RS23010: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CN325_RS23015: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CN325_RS23020: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Translocases: permease

CN325_RS23070: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

CN325_RS23085: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.73	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.73	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.15 out of 18.46

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.03 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.01 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.20 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06

Confidence: medium

Additional weak hits (5):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.25 out of 30.11

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.64 out of 31.73

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.08 out of 36.54

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 32375 - 98290:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Thr) + (X - Ala) + (Ser - Leu - D-X - Glu)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

CN325_RS23010: Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (457..866): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

CN325_RS23015: X - Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (466..870): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: YWMTFDVSVWEWQFFSGGETNFYGPTEATIYVNA
Nearest Stachelhaus code(s):: Glu DVWHFGRINK (71% 8Å match); Gln DAWQFGLIDK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1527..1919): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: MWATFDLSVFEVNTNLAGEFNLYGPSEDTTYSTY
Nearest Stachelhaus code(s):: Ala DLFNNALTYK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

CN325_RS23020: Ser - Leu - X - Glu

Search NORINE for peptide: strict or relaxed

AMP-binding (496..901): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFTSGEINLYGPTEATVDVTY
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1558..1945): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: MWHAFDSAVQEPFAITGGDINQYGPSENTVVTTD
Nearest Stachelhaus code(s):: Pro DVQFIAQVVK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (2600..3000): X

nrpys: Gln, Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDASIQQMDILVGGEYNVYGPTECTVDATC
Nearest Stachelhaus code(s):: Gln or Glu DAQDLGVVDK (88% 8Å match); Ile DAQDLGVVDK (85% 8Å match); Gln DAQDLGVVDK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4117..4517): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDVSIQQMDMLVGGEYNVYGPTECTVDATC
Nearest Stachelhaus code(s):: Gln or Glu DAQDLGVVDK (85% 8Å match); Ile DAQDLGVVDK (82% 8Å match); Gln DAQDLGVVDK (76% 8Å match)
Stachelhaus code match:: 90% (moderate)

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence

NZ_NTSF01000031.1 - Region 1 - NRPS-like

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Location: 1 - 40,251 nt. (total: 40,251 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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KnownClusterBlast

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TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidase

CN325_RS23735: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: phosphorylase phosphotransferase

CN325_RS23700: thiamine-phosphate pyrophosphorylase

smcogs: SMCOG1280: thiamine-phosphate pyrophosphorylase

CN325_RS23725: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Hydrolases: glucosidase

CN325_RS23730: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

Ligases: ligase

CN325_RS23685: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001758.4	0.59	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001758.4	0.59	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.69 out of 27.55

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.83 out of 27.78

Confidence: strong

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.71 out of 25.88

Confidence: medium

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 25.04 out of 26.12

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.18 out of 23.79

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.99 out of 29.38

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.69 out of 21.55

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19

Confidence: strong

Additional weak hits (9):

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.06 out of 29.72

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.70 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.72 out of 32.74

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.11 out of 20.47

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.78 out of 31.73

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.33 out of 29.51

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.98 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 40251:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

CN325_RS23685: X

AMP-binding (225..621): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LWMPFDASVWEAALAIGGEHNVYGPTECTVVTTT
Nearest Stachelhaus code(s):: Leu DAWYLGNVVK (71% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
LuxO	Repressor of luminescence
PsrA	Oleic acid responsive regulator
ZuR variant 1	Zinc-responsive repressor

NZ_NTSF01000032.1 - Region 1 - RiPP-like

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Location: 1 - 7,284 nt. (total: 7,284 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

CN325_RS24245: aminotransferase

smcogs: SMCOG1019: aminotransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000896.5	0.29	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000721.4	0.27	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000172.5	0.23	PKS	Basiliskamide A, Basiliskamide B	Brevibacillus laterosporus PE36
BGC0000381.5	0.23	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5	0.22	NRPS	surfactin	Bacillus velezensis FZB42
BGC0000455.6	0.22	NRPS, saccharide	vancomycin	Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2	0.22	other (other)	enduracididine	uncultured bacterium
BGC0001233.5	0.22	NRPS	feglymycin	Streptomyces sp. DSM 11171
BGC0001461.5	0.22	NRPS	Actinoidin B	Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5	0.22	NRPS	decaplanin	Amycolatopsis regifaucium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000896.5	0.29	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000721.4	0.27	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000172.5	0.23	PKS	Basiliskamide A, Basiliskamide B	Brevibacillus laterosporus PE36
BGC0000381.5	0.23	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5	0.22	NRPS	surfactin	Bacillus velezensis FZB42
BGC0000455.6	0.22	NRPS, saccharide	vancomycin	Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2	0.22	other (other)	enduracididine	uncultured bacterium
BGC0001233.5	0.22	NRPS	feglymycin	Streptomyces sp. DSM 11171
BGC0001461.5	0.22	NRPS	Actinoidin B	Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5	0.22	NRPS	decaplanin	Amycolatopsis regifaucium

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.24 out of 21.55

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.87 out of 32.93

Confidence: medium

Additional weak hits (2):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.35 out of 30.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_NTSF01000004.1 - Region 1 - azole-containing-RiPP

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Location: 92,618 - 116,124 nt. (total: 23,507 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

CN325_RS03830: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.44	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0002013.4	0.44	ribosomal	curacozole	Streptomyces curacoi
BGC0000607.5	0.43	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001535.3	0.43	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001146.5	0.41	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001145.5	0.38	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001640.3	0.38	ribosomal	kocurin	Kocuria rosea
BGC0000605.5	0.38	ribosomal	GE37468	Streptomyces sp. ATCC 55365

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.44	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0002013.4	0.44	ribosomal	curacozole	Streptomyces curacoi
BGC0000607.5	0.43	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001535.3	0.43	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001146.5	0.41	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001145.5	0.38	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001640.3	0.38	ribosomal	kocurin	Kocuria rosea
BGC0000605.5	0.38	ribosomal	GE37468	Streptomyces sp. ATCC 55365

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.43 out of 32.93

Confidence: medium

Additional weak hits (3):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.69 out of 39.62

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.85 out of 29.38

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 19.16 out of 30.12

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Heterocycloanthracin_C_RRE; Location: 0 - 100; Score: 183.5; RRE type: Thiopeptide_F_RRE; Location: 10 - 89; Score: 40.6

TFBS definitions

Regulator	Description
LexA variant 3	Repressor of DNA damage response

Core peptide predictions

No core peptides found.

NZ_NTSF01000056.1 - Region 1 - betalactone

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Location: 64,227 - 84,374 nt. (total: 20,148 nt) Show pHMM detection rules used

Region on contig edge.

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CN325_RS29375: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase carboxylase transferase

CN325_RS29330: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

CN325_RS29380: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

CN325_RS29400: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

CN325_RS29430: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Lyases: hydratase

CN325_RS29395: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

CN325_RS29390: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

CN325_RS29405: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.55	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000131.5	0.46	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000706.3	0.46	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001103.5	0.42	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001226.4	0.42	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.55	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000131.5	0.46	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000706.3	0.46	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001103.5	0.42	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001226.4	0.42	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.73 out of 29.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.44 out of 26.06

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

Additional weak hits (1):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
MogR	Repressor of flagellar motility genes
SypG	Regulator of biofilm formation and host colonization

NZ_NTSF01000005.1 - Region 1 - ranthipeptide

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Location: 23,423 - 44,845 nt. (total: 21,423 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001929.2	0.54	ribosomal	WGK	Streptococcus ferus
BGC0002583.2	0.50	ribosomal	tryglysin B	Streptococcus mutans UA159
BGC0000600.3	0.42	ribosomal	thurincin H	Bacillus thuringiensis
BGC0001796.5	0.36	NRPS	tauramamide	Brevibacillus laterosporus DSM 25
BGC0000905.5	0.35	other (other)	heme D1	Heliobacillus mobilis
BGC0000320.5	0.34	NRPS	cereulide	Bacillus cereus
BGC0000407.5	0.27	NRPS	plipastatin	Bacillus subtilis subsp. subtilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001929.2	0.54	ribosomal	WGK	Streptococcus ferus
BGC0002583.2	0.50	ribosomal	tryglysin B	Streptococcus mutans UA159
BGC0000600.3	0.42	ribosomal	thurincin H	Bacillus thuringiensis
BGC0001796.5	0.36	NRPS	tauramamide	Brevibacillus laterosporus DSM 25
BGC0000905.5	0.35	other (other)	heme D1	Heliobacillus mobilis
BGC0000320.5	0.34	NRPS	cereulide	Bacillus cereus
BGC0000407.5	0.27	NRPS	plipastatin	Bacillus subtilis subsp. subtilis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.84 out of 29.38

Confidence: medium

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 28.05 out of 32.74

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.65 out of 29.38

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.74 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

Additional weak hits (5):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.87 out of 20.01

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.72 out of 19.52

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.60 out of 26.85

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Streptide_RRE; Location: 29 - 98; Score: 35.3; RRE type: Stand_Alone_Lasso_RRE; Location: 10 - 81; Score: 27.3

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
FuR variant 2	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_NTSF01000008.1 - Region 1 - NI-siderophore