GCF_002562915.1 - 17 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_NTSR01000019.1 (Bacillus thuringiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	t3nrps-iterative	109,247	156,789
Region 10.2	NI-siderophore	167,752	199,459	High	petrobactin	other:other

NZ_NTSR01000020.1 (Bacillus thuringiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	terpene	123,333	145,186	Low	molybdenum cofactor	other:other

NZ_NTSR01000021.1 (Bacillus thuringiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	RRE-containing	1	17,900

NZ_NTSR01000024.1 (Bacillus thuringiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 16.1	ranthipeptide	103,984	116,972

NZ_NTSR01000027.1 (Bacillus thuringiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 19.1	azole-containing-RiPP	25,302	48,808

NZ_NTSR01000029.1 (Bacillus thuringiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	lanthipeptide-class-ii,RiPP-like	50,961	79,736	Low	bicereucin	ribosomal:RiPP

NZ_NTSR01000031.1 (Bacillus thuringiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 24.1	NRPS	53,581	86,420

NZ_NTSR01000033.1 (Bacillus thuringiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 26.1	NRPS-like	31,499	75,080

NZ_NTSR01000034.1 (Bacillus thuringiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 27.1	lanthipeptide-class-ii	19,033	41,227	Low	bacillicn CER074	ribosomal:RiPP:Glycocin+terpene

NZ_NTSR01000003.1 (Bacillus thuringiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 33.1	terpene-precursor	448,634	469,524

NZ_NTSR01000040.1 (Bacillus thuringiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 34.1	RiPP-like	38,642	48,971
Region 34.2	betalactone	99,726	124,964	Low	fengycin	NRPS:Type I

NZ_NTSR01000007.1 (Bacillus thuringiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 60.1	NRPS	5,472	71,380

NZ_NTSR01000008.1 (Bacillus thuringiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 65.1	NRP-metallophore,NRPS	127,568	179,316	High	bacillibactin	NRPS:Type I

NZ_NTSR01000009.1 (Bacillus thuringiensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 67.1	NRPS	58,035	105,051
Region 67.2	RiPP-like	124,247	134,507

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	t3nrps-iterative	109,247	156,789
Region 10.2	NI-siderophore	167,752	199,459	High	petrobactin	other:other
Region 12.1	terpene	123,333	145,186	Low	molybdenum cofactor	other:other
Region 13.1	RRE-containing	1	17,900
Region 16.1	ranthipeptide	103,984	116,972
Region 19.1	azole-containing-RiPP	25,302	48,808
Region 21.1	lanthipeptide-class-ii,RiPP-like	50,961	79,736	Low	bicereucin	ribosomal:RiPP
Region 24.1	NRPS	53,581	86,420
Region 26.1	NRPS-like	31,499	75,080
Region 27.1	lanthipeptide-class-ii	19,033	41,227	Low	bacillicn CER074	ribosomal:RiPP:Glycocin+terpene
Region 33.1	terpene-precursor	448,634	469,524
Region 34.1	RiPP-like	38,642	48,971
Region 34.2	betalactone	99,726	124,964	Low	fengycin	NRPS:Type I
Region 60.1	NRPS	5,472	71,380
Region 65.1	NRP-metallophore,NRPS	127,568	179,316	High	bacillibactin	NRPS:Type I
Region 67.1	NRPS	58,035	105,051
Region 67.2	RiPP-like	124,247	134,507

No secondary metabolite regions were found in these records:: NZ_NTSR01000010.1 (Bacillus thuringiensis); NZ_NTSR01000011.1 (Bacillus thuringiensis); NZ_NTSR01000012.1 (Bacillus thuringiensis); NZ_NTSR01000013.1 (Bacillus thuringiensis); NZ_NTSR01000014.1 (Bacillus thuringiensis); NZ_NTSR01000015.1 (Bacillus thuringiensis); NZ_NTSR01000016.1 (Bacillus thuringiensis); NZ_NTSR01000017.1 (Bacillus thuringiensis); NZ_NTSR01000018.1 (Bacillus thuringiensis); NZ_NTSR01000001.1 (Bacillus thuringiensis); NZ_NTSR01000022.1 (Bacillus thuringiensis); NZ_NTSR01000023.1 (Bacillus thuringiensis); NZ_NTSR01000025.1 (Bacillus thuringiensis); NZ_NTSR01000026.1 (Bacillus thuringiensis); NZ_NTSR01000028.1 (Bacillus thuringiensis); NZ_NTSR01000002.1 (Bacillus thuringiensis); NZ_NTSR01000030.1 (Bacillus thuringiensis); NZ_NTSR01000032.1 (Bacillus thuringiensis); NZ_NTSR01000035.1 (Bacillus thuringiensis); NZ_NTSR01000036.1 (Bacillus thuringiensis); NZ_NTSR01000037.1 (Bacillus thuringiensis); NZ_NTSR01000038.1 (Bacillus thuringiensis); NZ_NTSR01000039.1 (Bacillus thuringiensis); NZ_NTSR01000041.1 (Bacillus thuringiensis); NZ_NTSR01000042.1 (Bacillus thuringiensis); NZ_NTSR01000043.1 (Bacillus thuringiensis); NZ_NTSR01000044.1 (Bacillus thuringiensis); NZ_NTSR01000045.1 (Bacillus thuringiensis); NZ_NTSR01000046.1 (Bacillus thuringiensis); NZ_NTSR01000047.1 (Bacillus thuringiensis); NZ_NTSR01000048.1 (Bacillus thuringiensis); NZ_NTSR01000049.1 (Bacillus thuringiensis); NZ_NTSR01000004.1 (Bacillus thuringiensis); NZ_NTSR01000051.1 (Bacillus thuringiensis); NZ_NTSR01000052.1 (Bacillus thuringiensis); NZ_NTSR01000053.1 (Bacillus thuringiensis); NZ_NTSR01000055.1 (Bacillus thuringiensis); NZ_NTSR01000056.1 (Bacillus thuringiensis); NZ_NTSR01000057.1 (Bacillus thuringiensis); NZ_NTSR01000059.1 (Bacillus thuringiensis); NZ_NTSR01000005.1 (Bacillus thuringiensis); NZ_NTSR01000062.1 (Bacillus thuringiensis); NZ_NTSR01000067.1 (Bacillus thuringiensis); NZ_NTSR01000069.1 (Bacillus thuringiensis); NZ_NTSR01000006.1 (Bacillus thuringiensis); NZ_NTSR01000072.1 (Bacillus thuringiensis); NZ_NTSR01000074.1 (Bacillus thuringiensis); NZ_NTSR01000075.1 (Bacillus thuringiensis); NZ_NTSR01000081.1 (Bacillus thuringiensis); NZ_NTSR01000083.1 (Bacillus thuringiensis); NZ_NTSR01000085.1 (Bacillus thuringiensis); NZ_NTSR01000088.1 (Bacillus thuringiensis); NZ_NTSR01000091.1 (Bacillus thuringiensis)

Compact view

NZ_NTSR01000019.1 - Region 1 - t3nrps-iterative

Download region GenBank file

Download region SVG

Location: 109,247 - 156,789 nt. (total: 47,543 nt) Show pHMM detection rules used

t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase aminotransferase glycosyltransferase transferase

CN358_RS18155: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

CN358_RS18165: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

CN358_RS18275: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

CN358_RS18280: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

Hydrolases: amidase hydrolase

CN358_RS18080: amidase

smcogs: SMCOG1105: amidase

CN358_RS18175: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Lyases: dehydratase

CN358_RS18160: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase

CN358_RS18105: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

CN358_RS18180: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002450.2	0.53	other (other)	sarasinoside	uncultured bacterium
BGC0000820.5	0.50	other (other)	physostigmine	Streptomyces griseofuscus
BGC0000410.5	0.49	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0000699.5	0.47	saccharide	hygromycin A	Streptomyces hygroscopicus subsp. hygroscopicus
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001488.3	0.46	other (other)	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0000294.5	0.46	NRPS	acinetobactin	Acinetobacter baumannii
BGC0001747.3	0.45	other (other)	pseudaminic acid	Tannerella forsythia
BGC0000773.3	0.45	saccharide	lipopolysaccharide	Escherichia coli
BGC0002042.3	0.45	NRPS	anthelvencin A, anthelvencin B, anthelvencin C	Streptomyces venezuelae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002450.2	0.53	other (other)	sarasinoside	uncultured bacterium
BGC0000820.5	0.50	other (other)	physostigmine	Streptomyces griseofuscus
BGC0000410.5	0.49	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0000699.5	0.47	saccharide	hygromycin A	Streptomyces hygroscopicus subsp. hygroscopicus
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001488.3	0.46	other (other)	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0000294.5	0.46	NRPS	acinetobactin	Acinetobacter baumannii
BGC0001747.3	0.45	other (other)	pseudaminic acid	Tannerella forsythia
BGC0000773.3	0.45	saccharide	lipopolysaccharide	Escherichia coli
BGC0002042.3	0.45	NRPS	anthelvencin A, anthelvencin B, anthelvencin C	Streptomyces venezuelae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.11 out of 30.25

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.18 out of 27.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.21 out of 26.06

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.35 out of 27.55

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.74 out of 27.78

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.75 out of 28.19

Confidence: strong

Additional weak hits (3):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.37 out of 25.88

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.76 out of 30.11

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.69 out of 30.12

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

CN358_RS18180: X

AMP-binding (7..395): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: EQLAHAGFAFGAIALTAGGNNVYGMTETGAISIL
Nearest Stachelhaus code(s):: Val DALVLAVAIK (35% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
GnfM	Regulator of nitrogen-fixation genes
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_NTSR01000019.1 - Region 2 - NI-siderophore

Download region GenBank file

Download region SVG

Location: 167,752 - 199,459 nt. (total: 31,708 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

CN358_RS18485: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: deacetylase

CN358_RS18420: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: ligase synthase

CN358_RS18395: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

CN358_RS18450: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000942.4	0.88	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0002469.2	0.54	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001572.3	0.51	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002620.2	0.50	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0002692.2	0.50	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0002305.2	0.50	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0001713.5	0.48	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002633.2	0.47	other (other)	schizokinen	Leptolyngbya sp. PCC 7376

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000942.4	0.88	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0002469.2	0.54	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001572.3	0.51	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002620.2	0.50	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0002692.2	0.50	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0002305.2	0.50	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0001713.5	0.48	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002633.2	0.47	other (other)	schizokinen	Leptolyngbya sp. PCC 7376

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.03 out of 20.97

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.99 out of 30.25

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.38 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.93 out of 28.19

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.13 out of 18.16

Confidence: strong

Additional weak hits (4):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.88 out of 26.12

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.50 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.66 out of 32.74

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.60 out of 36.54

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
ColR	Phenol-responsive regulator
FuR variant 1	Ferric Uptake Regulator
ZuR variant 1	Zinc-responsive repressor

NZ_NTSR01000020.1 - Region 1 - terpene

Download region GenBank file

Download region SVG

Location: 123,333 - 145,186 nt. (total: 21,854 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CN358_RS19725: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CN358_RS19730: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Lyases: lyase

CN358_RS19755: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.53	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000916.5	0.46	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000812.3	0.45	other (other)	huperzine A	Shiraia sp. slf14
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001197.5	0.42	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002138.2	0.40	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.53	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000916.5	0.46	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000812.3	0.45	other (other)	huperzine A	Shiraia sp. slf14
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001197.5	0.42	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002138.2	0.40	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

CN358_RS19715: T2TS

Domain 1 (4 - 614): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 26.42 out of 30.22

Confidence: medium

Additional weak hits (1):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.61 out of 36.54

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
ClgR	Caseinolytic protease gene regulator

NZ_NTSR01000021.1 - Region 1 - RRE-containing

Download region GenBank file

Download region SVG

Location: 1 - 17,900 nt. (total: 17,900 nt) Show pHMM detection rules used

Region on contig edge.

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: lyase

CN358_RS19940: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.57	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002458.3	0.50	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0000308.5	0.43	NRPS	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0002645.3	0.42	other (other)	fluopsin C	Pseudomonas aeruginosa PAO1
BGC0001286.3	0.40	other (other)	itaconic acid	Ustilago maydis
BGC0002555.3	0.40	NRPS, PKS	emerimicin V, emerimicin VI, emerimicin VII, emerimicin VIII, emerimicin IX, emerimicin X	Acremonium sp.
BGC0001295.5	0.39	other (other)	cremeomycin	Streptomyces cremeus
BGC0000937.5	0.37	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0001037.5	0.37	NRPS, PKS	pseurotin, azaspirene	Aspergillus fumigatus Af293
BGC0000430.5	0.36	NRPS, PKS	spumigin E, Spumigin E	Nodularia spumigena CCY9414

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.57	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002458.3	0.50	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0000308.5	0.43	NRPS	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0002645.3	0.42	other (other)	fluopsin C	Pseudomonas aeruginosa PAO1
BGC0001286.3	0.40	other (other)	itaconic acid	Ustilago maydis
BGC0002555.3	0.40	NRPS, PKS	emerimicin V, emerimicin VI, emerimicin VII, emerimicin VIII, emerimicin IX, emerimicin X	Acremonium sp.
BGC0001295.5	0.39	other (other)	cremeomycin	Streptomyces cremeus
BGC0000937.5	0.37	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0001037.5	0.37	NRPS, PKS	pseurotin, azaspirene	Aspergillus fumigatus Af293
BGC0000430.5	0.36	NRPS, PKS	spumigin E, Spumigin E	Nodularia spumigena CCY9414

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.77 out of 26.06

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.85 out of 30.25

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.94 out of 25.31

Confidence: medium

Additional weak hits (2):

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.72 out of 32.93

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.40 out of 20.01

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Pantocin_Microcin_RRE; Location: 0 - 94; Score: 93.6

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
ColR	Phenol-responsive regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_NTSR01000024.1 - Region 1 - ranthipeptide

Download region GenBank file

Download region SVG

Location: 103,984 - 116,972 nt. (total: 12,989 nt) Show pHMM detection rules used

Region on contig edge.

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Isomerases: mutase

CN358_RS22425: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Similar gene clusters

Analysis type:

Reference	ranthipeptide	Similarity score	Type	Compound(s)	Organism
BGC0002306.2		0.47	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001796.5		0.26	NRPS	tauramamide	Brevibacillus laterosporus DSM 25

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0002306.2		0.47	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001796.5		0.26	NRPS	tauramamide	Brevibacillus laterosporus DSM 25

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.83 out of 26.06

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.83 out of 23.79

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.55 out of 21.55

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

Additional weak hits (3):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 24.04 out of 33.73

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.04 out of 27.55

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.65 out of 30.11

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Ranthipeptide_rSAM_RRE; Location: 0 - 104; Score: 98.9

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes

NZ_NTSR01000027.1 - Region 1 - azole-containing-RiPP

Download region GenBank file

Download region SVG

Location: 25,302 - 48,808 nt. (total: 23,507 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

CN358_RS23395: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.44	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0002013.4	0.44	ribosomal	curacozole	Streptomyces curacoi
BGC0000607.5	0.43	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001535.3	0.43	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001146.5	0.41	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001145.5	0.38	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001640.3	0.38	ribosomal	kocurin	Kocuria rosea
BGC0000605.5	0.38	ribosomal	GE37468	Streptomyces sp. ATCC 55365

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.44	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0002013.4	0.44	ribosomal	curacozole	Streptomyces curacoi
BGC0000607.5	0.43	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001535.3	0.43	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001146.5	0.41	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001145.5	0.38	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001640.3	0.38	ribosomal	kocurin	Kocuria rosea
BGC0000605.5	0.38	ribosomal	GE37468	Streptomyces sp. ATCC 55365

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.43 out of 32.93

Confidence: medium

Additional weak hits (4):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.85 out of 29.38

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.05 out of 30.97

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.41 out of 30.12

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.76 out of 30.12

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Heterocycloanthracin_C_RRE; Location: 0 - 100; Score: 184.8; RRE type: Thiopeptide_F_RRE; Location: 10 - 89; Score: 41.3

TFBS definitions

Regulator	Description
LexA variant 3	Repressor of DNA damage response
ToxT	Regulator of MSHA biosynthesis

Core peptide predictions

No core peptides found.

NZ_NTSR01000029.1 - Region 1 - RiPP-like,lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 50,961 - 79,736 nt. (total: 28,776 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: halogenase

CN358_RS25125: halogenase

smcogs: SMCOG1119: halogenase

Hydrolases: protease

CN358_RS25160: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

CN358_RS25170: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

CN358_RS25185: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.39	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000622.5	0.36	ribosomal	megacin	Bacillus megaterium
BGC0001407.5	0.28	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0001618.3	0.24	ribosomal	hyicin 3682	Staphylococcus hyicus
BGC0000517.4	0.24	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000552.3	0.23	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0002663.2	0.23	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000554.4	0.23	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000508.3	0.22	ribosomal	epidermin	Staphylococcus epidermidis
BGC0000502.5	0.22	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.60	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000517.4	0.57	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000552.3	0.56	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000626.3	0.55	ribosomal	thuricin	Bacillus thuringiensis
BGC0000497.3	0.54	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000555.3	0.54	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0000525.5	0.54	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0002110.3	0.54	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CN358_RS25170

CN358_RS25150

Leader:

MENKIKVYRERKAISQG

Core:

KLAELCNVSRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLFLPMKIERGE

Core with dehydrations:

KLAELCysNVDhaRQDhbINAIENKKYDPDhaLQLAFDIDhaKQLEIKMEDLFLPMKIERGE

antiSMASH-DB 4.0 matches for CN358_RS25150

100.0%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25150_lanthipeptide

Lanthipeptides: CN358_RS25150_lanthipeptide

1

KLAELCNVSRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLFLPMKIERGE

52

KLAELCNVSRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLFLPMKIERGE

1

KLAELCNVSRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLFLPMKIERGE

52

40.4%

NZ_QICS01000003.1:

Lanthipeptides: C8E03_RS08720_lanthipeptide

4

ELCNVSRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLF

43

+L NVS +TI +IEN+KY PSL LA+ I++ ++ MEDL+

1

KLVNVSSRTIISIENEKYKPSLILAYRIAEIFKVSMEDLY

40

40.4%

NZ_SBIS02000007.1:

Lanthipeptides: EPL00_RS13710_lanthipeptide

7

NVSRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLFLP

45

V+RQTINAIE ++YDPS++LAF ++ + ++EDLF P

2

GVTRQTINAIERERYDPSIELAFKLADHFDCRIEDLFDP

40

with 5 more sequence matches

36.5%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27555_lanthipeptide

9

SRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLF

43

+RQTI+A+E KY PSL+LAF I K LE ++++F

1

TRQTISAVEKNKYSPSLELAFKICKVLEKSIDEVF

35

34.6%

NZ_NVMQ01000017.1:

Lanthipeptides: CON32_RS17800_lanthipeptide

9

SRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLF

43

+RQTI+A+E KY PSL LAF I K +E++F

1

TRQTISALEKNKYTPSLDLAFRICKIFGRTVEEVF

35

32.7%

NZ_QPJT01000003.1:

Lanthipeptides: DFR58_RS03990_lanthipeptide

9

SRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLF

43

+RQTI ++E +KY SL LA+ I+K E +ED+F

1

TRQTITSLECEKYTASLILAYKIAKYFETTIEDIF

35

25.0%

NZ_QUCI01000001.1:

Lanthipeptides: DW648_RS00980_lanthipeptide

9

SRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLF

43

SR T+++IE +++P+ +LA + L+ K E+LF

1

SRNTVSSIETGQFNPTAKLALVLCIALDKKFEELF

35

13.5%

NZ_QRDO01000002.1:

Lanthipeptides: allorf_1070522_1070680_lanthipeptide

3

AELCNVSRQTINAIENKKYD

22

AE C+ RQT +++ + +D

9

AECCDAVRQTGHSLRCRAFD

28

CN358_RS25165

Leader:

MEIKNEFEMIGLVDEQELLELCGA

Core:

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRCR

Core with dehydrations:

AEVNPRDhbDhbVPCysAVGGADhbVGIDhbIYDhbFDRDhaHQDhaCysPDhbDhaACysDhaDhaRCysR

antiSMASH-DB 4.0 matches for CN358_RS25165

100.0%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRCR

42

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRCR

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRCR

42

47.6%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07270_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptide

Lanthipeptides: MOK21_RS07270_lanthipeptide

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

EVNPR++ G V +TIYT S SCP++ACS+RC

1

GEVNPRSS-----WGCVVQVTIYTISDSMNSCPSTACSTRC

36

47.6%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07275_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptide

Lanthipeptides: MOK21_RS07275_lanthipeptide

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

EVNPR++ C V +TIYT S SCP++ACS+RC

1

GEVNPRSSWGCVVQ-----VTIYTISDSMNSCPSTACSTRC

36

with 117 more sequence matches

Only the first 10 are displayed here.

45.2%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29340_lanthipeptide

Lanthipeptides: CN427_RS29340_lanthipeptide

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

AEV R+++PCA G TV + + F S ++CPT ACS C

1

AEVETRSSLPCA--GLTVAVGTWVFQTSEKTCPTLACSKAC

39

42.9%

NZ_BMFU01000012.1and 1 other:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25390_lanthipeptide

Lanthipeptides: IEW26_RS25390_lanthipeptide

2

EVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

EV ++ PCA+ V I+T S SCP++ACSSRC

2

EVQAASSWPCAIVPPVV---IWTITDSANSCPSTACSSRC

38

42.9%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: HNR77_RS17300_lanthipeptide

Lanthipeptides: HNR77_RS17300_lanthipeptide

2

EVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

EV ++ PCA+ V I+T S SCP++ACSSRC

2

EVQVASSWPCAIVPPVV---IWTITDSANSCPSTACSSRC

38

42.9%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07280_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptide

Lanthipeptides: MOK21_RS07280_lanthipeptide

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

EVNPR++ C + +TI+T S SCP++ACS+RC

1

GEVNPRSSWGCVID-----VTIWTITDSMNSCPSTACSTRC

36

42.9%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS31525_lanthipeptide

Lanthipeptides: CN427_RS31525_lanthipeptide

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

AEV R++VPC TV + + F S ++CPT ACS C

1

AEVETRSSVPCV--SLTVAVGTWVFQTSDKTCPTLACSKAC

39

42.9%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide

Lanthipeptides: DT250_RS18265_lanthipeptide

2

EVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

EV P TT CA I+T + Q CPT+ACSS+C

3

EVTPYTTWGCA---------IFTIASAAQ-CPTTACSSKC

32

40.5%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

2

EVNPRTT--VPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

+VNP TT P +G AT+ +T CPT+ C+SRC

2

DVNPETTPATPTIIG-ATIAVT-------ASLCPTTKCTSRC

35

40.5%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

7

TTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

TTVPCA+GG + I+ D CPT AC++RC

4

TTVPCAIGGGVIAISAALPDF----CPTGACTTRC

34

40.5%

NZ_JAHXMW010000012.1and 3 others:

NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23840_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptide

Lanthipeptides: KZX51_RS23840_lanthipeptide

2

EVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

EV ++ PCA+ + I+T S SCP++ACSSRC

2

EVQVASSWPCAIVPP---VLIWTITDSANSCPSTACSSRC

38

38.1%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide

Lanthipeptides: BLI_RS20290_lanthipeptide

2

EVNPRTT------VPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

+VNP TT C G TV ++ CPT+ C+SRC

2

DVNPETTPATTSSWTCITAGVTVSASL---------CPTTKCTSRC

38

MIBiG 4.0 matches for CN358_RS25165

19.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

28

SHQSCPTSACSSRC

41

S CPT+ C+SRC

24

SAAFCPTTKCTSRC

37

14.3%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

32

CPTSACSSRC

41

CPT+ C+S+C

17

CPTTKCTSKC

26

CN358_RS25180

Leader:

MTKELKALKNPYYRHQNNVNVNLPVENPLKELNEDEMSMFG

Core:

GAAEPRTIGSFNSADYIKLSIGLGNNGYICTYTVECQKNCN

Core with dehydrations:

GAAEPRDhbIGDhaFNDhaADYIKLDhaIGLGNNGYICysDhbYDhbVECysQKNCysN

antiSMASH-DB 4.0 matches for CN358_RS25180

100.0%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25180_lanthipeptide

Lanthipeptides: CN358_RS25180_lanthipeptide

1

GAAEPRTIGSFNSADYIKLSIGLGNNGYICTYTVECQKNCN

41

GAAEPRTIGSFNSADYIKLSIGLGNNGYICTYTVECQKNCN

1

GAAEPRTIGSFNSADYIKLSIGLGNNGYICTYTVECQKNCN

41

45.2%

NZ_BMFU01000012.1and 5 others:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide

Lanthipeptides: IEW26_RS25375_lanthipeptide

1

GAAEPRTIGSF-NSADYIKLSIGLGNNGYICTYTVECQKNCN

41

GAA+P + S S +GN G++CT TVECQK+CN

1

GAAQPEWVEVIITSLACAAASYFMGNPGHVCTLTVECQKSCN

42

45.2%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide

Lanthipeptides: allorf_027480_027638_lanthipeptide

1

GAAEPRTIGSF-NSADYIKLSIGLGNNGYICTYTVECQKNCN

41

GAA+P+ S S +GN G++CT TVECQK+CN

1

GAAQPQWAEVIITSLACAAASYFMGNPGHVCTLTVECQKSCN

42

with 107 more sequence matches

Only the first 10 are displayed here.

43.9%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

11

FNSADYIKLSIGLGNNGYICTYTVECQKNCN

41

F + Y S LGNNG++CT TVECQKNC

3

FETVTYTVASWALGNNGHLCTVTVECQKNCQ

33

41.5%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09360_lanthipeptide

Lanthipeptides: AOX59_RS09360_lanthipeptide

4

EPRTIGSFNSADYIKLSIGLGNNGYICTYTVECQKNCN

41

+P+T ++++ +I S +GN+G++CT TVECQ NCN

3

DPQTALTYSTCHWI--SPAMGNDGHLCTATVECQPNCN

38

41.5%

NZ_CP115450.1and 1 other:

NZ_CP115450.1 Lanthipeptides: O1G21_RS35415_lanthipeptide

Lanthipeptides: O1G21_RS35415_lanthipeptide

9

GSFNSADYIKLSIGLGNNGYICTYTVECQKNCN

41

G Y S +GNNGY+CT T ECQKNC

4

GPIEVLTYTAASWAMGNNGYLCTVTAECQKNCQ

36

41.5%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

13

SADYIKLSIGLGNNGYICTYTVECQKNCN

41

+A YI LGN G++CT TVECQK CN

17

AASYI-----LGNPGHVCTLTVECQKKCN

40

39.0%

NC_018089.1and 11 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08725_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptide

Lanthipeptides: SMUGS5_RS08725_lanthipeptide

19

LSIGLGNNGYICTYTVECQKNCN

41

SI LGN GYICT TVEC +NC+

10

FSIVLGNKGYICTVTVECMRNCS

32

39.0%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

13

SADYIKLSIGLGNNGYICTYTVECQKNCN

41

S + LS LGN G CT T ECQ NCN

2

STNTFSLSDFLGNQGGWCTLTKECQPNCN

30

39.0%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

13

SADYIKLSIGLGNNGYICTYTVECQKNCN

41

+ + LS LGN G CT TVECQ NCN

2

TTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

39.0%

NZ_CP043405.1and 1 other:

NZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptide

Lanthipeptides: FY406_RS04355_lanthipeptide

19

LSIGLGNNGYICTYTVECQKNC

40

SI LGN GYICT TVEC +NC

10

FSIVLGNKGYICTVTVECMRNC

31

39.0%

NZ_GG657754.1and 1 other:

NZ_GG657754.1 Lanthipeptides: SSOG_RS49055_lanthipeptide

Lanthipeptides: SSOG_RS49055_lanthipeptide

10

SFNSADYIKLSIGLGNNGYICTYTVECQKNC

40

+F A+Y+ +S +GN G CT T+ECQKNC

1

TFGGAEYV-VSFVMGNLGNFCTATLECQKNC

30

39.0%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

7

TIGSFNSADYIKLSIGLGNNGYICTYTVECQKNCN

41

T +F +DY LGN G CT T ECQ++CN

2

TTNTFTLSDY------LGNKGGWCTLTKECQRSCN

30

MIBiG 4.0 matches for CN358_RS25180

39.0%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

13

SADYIKLSIGLGNNGYICTYTVECQKNCN

41

+ + LS LGNNG CT T ECQ NCN

2

TTNTFSLSNALGNNGGWCTLTKECQPNCN

30

31.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

16

YIKLSIGLGNNGYICTYTVECQKNCN

41

+ +S LGN G CT TVEC +CN

3

WYNISCRLGNKGAYCTLTVECMPSCN

28

19.5%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

30

CTYTVECQKNCN

41

CT + ECQ NCN

28

CTLSKECQPNCN

39

allorf_51353_51469

Leader:

MKYIVEKVESFVG

Core:

KCKTVCLMIVCFWLIMFLVAGEHFL

Core with dehydrations:

KCysKDhbVCysLMIVCysFWLIMFLVAGEHFL

antiSMASH-DB 4.0 matches for allorf_51353_51469

18.2%

NZ_KE386618.1:

Lanthipeptides: A3GQ_RS0121455_lanthipeptide

3

KTVCLMIVCFWLIMFLVAGEH

23

KT+C++ + + L+ GE

12

KTLCVLADSLNVSLSLILGER

32

15.6%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

4

TVCLMIVCFW

13

+VC + CFW

22

SVCPTLTCFW

31

MIBiG 4.0 matches for allorf_51353_51469

20.0%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

3

KTVCLMIVC

11

TVC+ I C

13

NTVCIGISC

21

allorf_51406_51507

Leader:

MSYDSVFLVNHVFS

Core:

GWRTLFITPNRGSATCPSS

Core with dehydrations:

GWRDhbLFIDhbPNRGDhaADhbCysPDhaDha

antiSMASH-DB 4.0 matches for allorf_51406_51507

22.2%

NZ_CP094676.1and 1 other:

NZ_CP094676.1 Lanthipeptides: allorf_0312859_0313026_lanthipeptide

Lanthipeptides: allorf_0312859_0313026_lanthipeptide

9

PNRGSATC

16

P+RGS+TC

8

PSRGSSTC

15

20.7%

NZ_AP023359.1:

Lanthipeptides: Prubr_RS32600_lanthipeptide

6

FITPNRGSATCPSS

19

++ P+R AT P+S

3

WLVPSRSYATAPAS

16

19.6%

NZ_CP035495.1and 1 other:

NZ_CP035495.1 Lanthipeptides: allorf_0927515_0927718_lanthipeptide

Lanthipeptides: allorf_0927515_0927718_lanthipeptide

5

LFITPNRGSATCPS

18

LF P+RG AT PS

19

LFQAPSRGLATAPS

32

with 1 more sequence matches

9.2%

NZ_CP003987.1:

Lanthipeptides: allorf_00516755_00516991_lanthipeptide

7

ITPNRGSATCP

17

+ RG ATCP

31

LARRRGGATCP

41

allorf_51931_52101

Leader:

MQKLLSQMKKRSPCIGAERRWKIHFS

Core:

WDLVFVDAKKSSLQAEASKWGRFIVNYFCT

Core with dehydrations:

WDLVFVDAKKDhaDhaLQAEADhaKWGRFIVNYFCysDhb

antiSMASH-DB 4.0 matches for allorf_51931_52101

23.3%

NZ_FQZK01000006.1and 2 others:

NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptideNZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide

Lanthipeptides: BUE45_RS13105_lanthipeptide

6

VDAKKSSLQAEASKWGRFIVNYFCT

30

+ A +S+ A ++ WG CT

1

ISATVASVTAISAAWGDGCPTTVCT

25

22.9%

NZ_FQVE01000004.1:

Lanthipeptides: allorf_451470_451649_lanthipeptide

18

SKWGRFIVNYFCT

30

S + R IVN FCT

6

SLYKRIIVNRFCT

18

20.0%

NZ_RYYV01000004.1:

Lanthipeptides: allorf_107615_107755_lanthipeptide

2

DLVFVDAKKSSLQAEASKWGRF

23

D + A ++ +Q +KW RF

13

DRHWKPAGRTDIQPPCAKWSRF

34

allorf_57712_57837

Leader:

MNLKNNKLNDLLGR

Core:

NKNIHHFQIITELHASVNLNCFAIVNM

Core with dehydrations:

NKNIHHFQIIDhbELHADhaVNLNCysFAIVNM

antiSMASH-DB 4.0 matches for allorf_57712_57837

100.0%

NZ_NTSR01000029.1:

Lanthipeptides: allorf_57712_57837_lanthipeptide

1

NKNIHHFQIITELHASVNLNCFAIVNM

27

NKNIHHFQIITELHASVNLNCFAIVNM

1

NKNIHHFQIITELHASVNLNCFAIVNM

27

19.4%

NZ_FOMK01000014.1:

Lanthipeptides: allorf_183755_183922_lanthipeptide

8

QIITELHASVNLNCFA

23

+ I EL S+N++C +

3

KSIGELSTSMNMDCVS

18

18.5%

NZ_KB976303.1:

Lanthipeptides: allorf_513973_514077_lanthipeptide

2

KNIHHFQIITE

12

KN+ HF+ + E

7

KNVQHFRFLRE

17

with 1 more sequence matches

12.9%

NZ_CP013707.1:

Lanthipeptides: RSJ2_RS22455_lanthipeptide

17

VNLNCFAIVN

26

VNL CF IVN

14

VNLICFTIVN

23

allorf_71672_71773

Leader:

MIISTFISFLKEYQAS

Core:

TFLDCILVSHKKGFPVM

Core with dehydrations:

DhbFLDCysILVDhaHKKGFPVM

antiSMASH-DB 4.0 matches for allorf_71672_71773

100.0%

NZ_NTSR01000029.1:

Lanthipeptides: allorf_71672_71773_lanthipeptide

1

TFLDCILVSHKKGFPVM

17

TFLDCILVSHKKGFPVM

1

TFLDCILVSHKKGFPVM

17

94.1%

NZ_MIFN01000022.1and 3 others:

NZ_MIFN01000022.1 Lanthipeptides: allorf_54314_54415_lanthipeptideNZ_NUIO01000031.1 Lanthipeptides: allorf_01256_01357_lanthipeptideNZ_NUIO01000031.1 Lanthipeptides: allorf_01256_01357_lanthipeptide

Lanthipeptides: allorf_54314_54415_lanthipeptide

1

TFLDCILVSHKKGFPVM

17

TFLDCILVSHKK FPVM

1

TFLDCILVSHKKSFPVM

17

allorf_73771_73842

Leader:

MGYNEFLSLIAM

Core:

CPSLSSFTISM

Core with dehydrations:

CysPDhaLDhaDhaFDhbIDhaM

antiSMASH-DB 4.0 matches for allorf_73771_73842

100.0%

NZ_NTSR01000029.1:

Lanthipeptides: allorf_73771_73842_lanthipeptide

1

CPSLSSFTISM

11

CPSLSSFTISM

1

CPSLSSFTISM

11

Lanthipeptide(s) for CN358_RS25185

CN358_RS25150

Leader:

MENKIKVYRERKAISQG

Core:

KLAELCNVSRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLFLPMKIERGE

Core with dehydrations:

KLAELCysNVDhaRQDhbINAIENKKYDPDhaLQLAFDIDhaKQLEIKMEDLFLPMKIERGE

antiSMASH-DB 4.0 matches for CN358_RS25150

100.0%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25150_lanthipeptide

Lanthipeptides: CN358_RS25150_lanthipeptide

1

KLAELCNVSRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLFLPMKIERGE

52

KLAELCNVSRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLFLPMKIERGE

1

KLAELCNVSRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLFLPMKIERGE

52

40.4%

NZ_QICS01000003.1:

Lanthipeptides: C8E03_RS08720_lanthipeptide

4

ELCNVSRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLF

43

+L NVS +TI +IEN+KY PSL LA+ I++ ++ MEDL+

1

KLVNVSSRTIISIENEKYKPSLILAYRIAEIFKVSMEDLY

40

40.4%

NZ_SBIS02000007.1:

Lanthipeptides: EPL00_RS13710_lanthipeptide

7

NVSRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLFLP

45

V+RQTINAIE ++YDPS++LAF ++ + ++EDLF P

2

GVTRQTINAIERERYDPSIELAFKLADHFDCRIEDLFDP

40

with 5 more sequence matches

36.5%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27555_lanthipeptide

9

SRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLF

43

+RQTI+A+E KY PSL+LAF I K LE ++++F

1

TRQTISAVEKNKYSPSLELAFKICKVLEKSIDEVF

35

34.6%

NZ_NVMQ01000017.1:

Lanthipeptides: CON32_RS17800_lanthipeptide

9

SRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLF

43

+RQTI+A+E KY PSL LAF I K +E++F

1

TRQTISALEKNKYTPSLDLAFRICKIFGRTVEEVF

35

32.7%

NZ_QPJT01000003.1:

Lanthipeptides: DFR58_RS03990_lanthipeptide

9

SRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLF

43

+RQTI ++E +KY SL LA+ I+K E +ED+F

1

TRQTITSLECEKYTASLILAYKIAKYFETTIEDIF

35

25.0%

NZ_QUCI01000001.1:

Lanthipeptides: DW648_RS00980_lanthipeptide

9

SRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLF

43

SR T+++IE +++P+ +LA + L+ K E+LF

1

SRNTVSSIETGQFNPTAKLALVLCIALDKKFEELF

35

13.5%

NZ_QRDO01000002.1:

Lanthipeptides: allorf_1070522_1070680_lanthipeptide

3

AELCNVSRQTINAIENKKYD

22

AE C+ RQT +++ + +D

9

AECCDAVRQTGHSLRCRAFD

28

CN358_RS25165

Leader:

MEIKNEFEMIGLVDEQELLELCGA

Core:

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRCR

Core with dehydrations:

AEVNPRDhbDhbVPCysAVGGADhbVGIDhbIYDhbFDRDhaHQDhaCysPDhbDhaACysDhaDhaRCysR

antiSMASH-DB 4.0 matches for CN358_RS25165

100.0%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRCR

42

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRCR

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRCR

42

47.6%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07270_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptide

Lanthipeptides: MOK21_RS07270_lanthipeptide

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

EVNPR++ G V +TIYT S SCP++ACS+RC

1

GEVNPRSS-----WGCVVQVTIYTISDSMNSCPSTACSTRC

36

47.6%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07275_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptide

Lanthipeptides: MOK21_RS07275_lanthipeptide

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

EVNPR++ C V +TIYT S SCP++ACS+RC

1

GEVNPRSSWGCVVQ-----VTIYTISDSMNSCPSTACSTRC

36

with 117 more sequence matches

Only the first 10 are displayed here.

45.2%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29340_lanthipeptide

Lanthipeptides: CN427_RS29340_lanthipeptide

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

AEV R+++PCA G TV + + F S ++CPT ACS C

1

AEVETRSSLPCA--GLTVAVGTWVFQTSEKTCPTLACSKAC

39

42.9%

NZ_BMFU01000012.1and 1 other:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25390_lanthipeptide

Lanthipeptides: IEW26_RS25390_lanthipeptide

2

EVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

EV ++ PCA+ V I+T S SCP++ACSSRC

2

EVQAASSWPCAIVPPVV---IWTITDSANSCPSTACSSRC

38

42.9%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: HNR77_RS17300_lanthipeptide

Lanthipeptides: HNR77_RS17300_lanthipeptide

2

EVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

EV ++ PCA+ V I+T S SCP++ACSSRC

2

EVQVASSWPCAIVPPVV---IWTITDSANSCPSTACSSRC

38

42.9%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07280_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptide

Lanthipeptides: MOK21_RS07280_lanthipeptide

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

EVNPR++ C + +TI+T S SCP++ACS+RC

1

GEVNPRSSWGCVID-----VTIWTITDSMNSCPSTACSTRC

36

42.9%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS31525_lanthipeptide

Lanthipeptides: CN427_RS31525_lanthipeptide

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

AEV R++VPC TV + + F S ++CPT ACS C

1

AEVETRSSVPCV--SLTVAVGTWVFQTSDKTCPTLACSKAC

39

42.9%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide

Lanthipeptides: DT250_RS18265_lanthipeptide

2

EVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

EV P TT CA I+T + Q CPT+ACSS+C

3

EVTPYTTWGCA---------IFTIASAAQ-CPTTACSSKC

32

40.5%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

2

EVNPRTT--VPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

+VNP TT P +G AT+ +T CPT+ C+SRC

2

DVNPETTPATPTIIG-ATIAVT-------ASLCPTTKCTSRC

35

40.5%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

7

TTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

TTVPCA+GG + I+ D CPT AC++RC

4

TTVPCAIGGGVIAISAALPDF----CPTGACTTRC

34

40.5%

NZ_JAHXMW010000012.1and 3 others:

NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23840_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptide

Lanthipeptides: KZX51_RS23840_lanthipeptide

2

EVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

EV ++ PCA+ + I+T S SCP++ACSSRC

2

EVQVASSWPCAIVPP---VLIWTITDSANSCPSTACSSRC

38

38.1%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide

Lanthipeptides: BLI_RS20290_lanthipeptide

2

EVNPRTT------VPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

+VNP TT C G TV ++ CPT+ C+SRC

2

DVNPETTPATTSSWTCITAGVTVSASL---------CPTTKCTSRC

38

MIBiG 4.0 matches for CN358_RS25165

19.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

28

SHQSCPTSACSSRC

41

S CPT+ C+SRC

24

SAAFCPTTKCTSRC

37

14.3%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

32

CPTSACSSRC

41

CPT+ C+S+C

17

CPTTKCTSKC

26

CN358_RS25180

Leader:

MTKELKALKNPYYRHQNNVNVNLPVENPLKELNEDEMSMFG

Core:

GAAEPRTIGSFNSADYIKLSIGLGNNGYICTYTVECQKNCN

Core with dehydrations:

GAAEPRDhbIGDhaFNDhaADYIKLDhaIGLGNNGYICysDhbYDhbVECysQKNCysN

antiSMASH-DB 4.0 matches for CN358_RS25180

100.0%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25180_lanthipeptide

Lanthipeptides: CN358_RS25180_lanthipeptide

1

GAAEPRTIGSFNSADYIKLSIGLGNNGYICTYTVECQKNCN

41

GAAEPRTIGSFNSADYIKLSIGLGNNGYICTYTVECQKNCN

1

GAAEPRTIGSFNSADYIKLSIGLGNNGYICTYTVECQKNCN

41

45.2%

NZ_BMFU01000012.1and 5 others:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide

Lanthipeptides: IEW26_RS25375_lanthipeptide

1

GAAEPRTIGSF-NSADYIKLSIGLGNNGYICTYTVECQKNCN

41

GAA+P + S S +GN G++CT TVECQK+CN

1

GAAQPEWVEVIITSLACAAASYFMGNPGHVCTLTVECQKSCN

42

45.2%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide

Lanthipeptides: allorf_027480_027638_lanthipeptide

1

GAAEPRTIGSF-NSADYIKLSIGLGNNGYICTYTVECQKNCN

41

GAA+P+ S S +GN G++CT TVECQK+CN

1

GAAQPQWAEVIITSLACAAASYFMGNPGHVCTLTVECQKSCN

42

with 107 more sequence matches

Only the first 10 are displayed here.

43.9%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

11

FNSADYIKLSIGLGNNGYICTYTVECQKNCN

41

F + Y S LGNNG++CT TVECQKNC

3

FETVTYTVASWALGNNGHLCTVTVECQKNCQ

33

41.5%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09360_lanthipeptide

Lanthipeptides: AOX59_RS09360_lanthipeptide

4

EPRTIGSFNSADYIKLSIGLGNNGYICTYTVECQKNCN

41

+P+T ++++ +I S +GN+G++CT TVECQ NCN

3

DPQTALTYSTCHWI--SPAMGNDGHLCTATVECQPNCN

38

41.5%

NZ_CP115450.1and 1 other:

NZ_CP115450.1 Lanthipeptides: O1G21_RS35415_lanthipeptide

Lanthipeptides: O1G21_RS35415_lanthipeptide

9

GSFNSADYIKLSIGLGNNGYICTYTVECQKNCN

41

G Y S +GNNGY+CT T ECQKNC

4

GPIEVLTYTAASWAMGNNGYLCTVTAECQKNCQ

36

41.5%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

13

SADYIKLSIGLGNNGYICTYTVECQKNCN

41

+A YI LGN G++CT TVECQK CN

17

AASYI-----LGNPGHVCTLTVECQKKCN

40

39.0%

NC_018089.1and 11 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08725_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptide

Lanthipeptides: SMUGS5_RS08725_lanthipeptide

19

LSIGLGNNGYICTYTVECQKNCN

41

SI LGN GYICT TVEC +NC+

10

FSIVLGNKGYICTVTVECMRNCS

32

39.0%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

13

SADYIKLSIGLGNNGYICTYTVECQKNCN

41

S + LS LGN G CT T ECQ NCN

2

STNTFSLSDFLGNQGGWCTLTKECQPNCN

30

39.0%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

13

SADYIKLSIGLGNNGYICTYTVECQKNCN

41

+ + LS LGN G CT TVECQ NCN

2

TTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

39.0%

NZ_CP043405.1and 1 other:

NZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptide

Lanthipeptides: FY406_RS04355_lanthipeptide

19

LSIGLGNNGYICTYTVECQKNC

40

SI LGN GYICT TVEC +NC

10

FSIVLGNKGYICTVTVECMRNC

31

39.0%

NZ_GG657754.1and 1 other:

NZ_GG657754.1 Lanthipeptides: SSOG_RS49055_lanthipeptide

Lanthipeptides: SSOG_RS49055_lanthipeptide

10

SFNSADYIKLSIGLGNNGYICTYTVECQKNC

40

+F A+Y+ +S +GN G CT T+ECQKNC

1

TFGGAEYV-VSFVMGNLGNFCTATLECQKNC

30

39.0%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

7

TIGSFNSADYIKLSIGLGNNGYICTYTVECQKNCN

41

T +F +DY LGN G CT T ECQ++CN

2

TTNTFTLSDY------LGNKGGWCTLTKECQRSCN

30

MIBiG 4.0 matches for CN358_RS25180

39.0%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

13

SADYIKLSIGLGNNGYICTYTVECQKNCN

41

+ + LS LGNNG CT T ECQ NCN

2

TTNTFSLSNALGNNGGWCTLTKECQPNCN

30

31.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

16

YIKLSIGLGNNGYICTYTVECQKNCN

41

+ +S LGN G CT TVEC +CN

3

WYNISCRLGNKGAYCTLTVECMPSCN

28

19.5%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

30

CTYTVECQKNCN

41

CT + ECQ NCN

28

CTLSKECQPNCN

39

CN358_RS25220

Leader:

YEAGEKALMDEVVKFA

Core:

HACNEGKKKALKKGFSKGKYK

Core with dehydrations:

HACysNEGKKKALKKGFDhaKGKYK

antiSMASH-DB 4.0 matches for CN358_RS25220

100.0%

NZ_NTSR01000029.1:

Lanthipeptides: CN358_RS25220_lanthipeptide

1

HACNEGKKKALKKGFSKGKYK

21

HACNEGKKKALKKGFSKGKYK

1

HACNEGKKKALKKGFSKGKYK

21

28.6%

NZ_MIFN01000022.1:

Lanthipeptides: allorf_50962_51126_lanthipeptide

3

CNEGKKKALKKGFSK

17

CNE K++ K+G ++

1

CNEEKRRHSKRGSAR

15

allorf_57712_57837

Leader:

MNLKNNKLNDLLGR

Core:

NKNIHHFQIITELHASVNLNCFAIVNM

Core with dehydrations:

NKNIHHFQIIDhbELHADhaVNLNCysFAIVNM

antiSMASH-DB 4.0 matches for allorf_57712_57837

100.0%

NZ_NTSR01000029.1:

Lanthipeptides: allorf_57712_57837_lanthipeptide

1

NKNIHHFQIITELHASVNLNCFAIVNM

27

NKNIHHFQIITELHASVNLNCFAIVNM

1

NKNIHHFQIITELHASVNLNCFAIVNM

27

19.4%

NZ_FOMK01000014.1:

Lanthipeptides: allorf_183755_183922_lanthipeptide

8

QIITELHASVNLNCFA

23

+ I EL S+N++C +

3

KSIGELSTSMNMDCVS

18

18.5%

NZ_KB976303.1:

Lanthipeptides: allorf_513973_514077_lanthipeptide

2

KNIHHFQIITE

12

KN+ HF+ + E

7

KNVQHFRFLRE

17

with 1 more sequence matches

12.9%

NZ_CP013707.1:

Lanthipeptides: RSJ2_RS22455_lanthipeptide

17

VNLNCFAIVN

26

VNL CF IVN

14

VNLICFTIVN

23

allorf_71672_71773

Leader:

MIISTFISFLKEYQAS

Core:

TFLDCILVSHKKGFPVM

Core with dehydrations:

DhbFLDCysILVDhaHKKGFPVM

antiSMASH-DB 4.0 matches for allorf_71672_71773

100.0%

NZ_NTSR01000029.1:

Lanthipeptides: allorf_71672_71773_lanthipeptide

1

TFLDCILVSHKKGFPVM

17

TFLDCILVSHKKGFPVM

1

TFLDCILVSHKKGFPVM

17

94.1%

NZ_MIFN01000022.1and 3 others:

NZ_MIFN01000022.1 Lanthipeptides: allorf_54314_54415_lanthipeptideNZ_NUIO01000031.1 Lanthipeptides: allorf_01256_01357_lanthipeptideNZ_NUIO01000031.1 Lanthipeptides: allorf_01256_01357_lanthipeptide

Lanthipeptides: allorf_54314_54415_lanthipeptide

1

TFLDCILVSHKKGFPVM

17

TFLDCILVSHKK FPVM

1

TFLDCILVSHKKSFPVM

17

allorf_73771_73842

Leader:

MGYNEFLSLIAM

Core:

CPSLSSFTISM

Core with dehydrations:

CysPDhaLDhaDhaFDhbIDhaM

antiSMASH-DB 4.0 matches for allorf_73771_73842

100.0%

NZ_NTSR01000029.1:

Lanthipeptides: allorf_73771_73842_lanthipeptide

1

CPSLSSFTISM

11

CPSLSSFTISM

1

CPSLSSFTISM

11

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.34 out of 30.25

Confidence: medium

Additional weak hits (2):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.22 out of 23.43

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

CN358_RS25150 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 5977.2 Da

Molecular weight: 5980.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5998.9 Da N = 1; 6017.0 Da N = 2; 6035.0 Da N = 3

CN358_RS25165 - Class II

Cleavage pHMM score: -0.50

RODEO score: 0

Monoisotopic mass: 4200.1 Da

Molecular weight: 4202.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4220.7 Da N = 1; 4238.7 Da N = 2; 4256.7 Da N = 3; 4274.8 Da N = 4; 4292.8 Da N = 5; 4310.8 Da N = 6; 4328.8 Da N = 7

CN358_RS25180 - Class II

Cleavage pHMM score: -1.20

RODEO score: 0

Monoisotopic mass: 4276.1 Da

Molecular weight: 4278.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4296.8 Da N = 1; 4314.8 Da N = 2; 4332.8 Da N = 3

CN358_RS25220 - Class II

Cleavage pHMM score: -4.90

RODEO score: 0

Monoisotopic mass: 2331.3 Da

Molecular weight: 2332.8 Da

Number of bridges: 1

allorf_57712_57837 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 3083.6 Da

Molecular weight: 3085.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3103.6 Da N = 1

allorf_71672_71773 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 1898.0 Da

Molecular weight: 1899.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1917.3 Da N = 1

allorf_73771_73842 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 1081.5 Da

Molecular weight: 1082.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1100.3 Da N = 1; 1118.3 Da N = 2; 1136.3 Da N = 3; 1154.4 Da N = 4

CN358_RS25150 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 5977.2 Da

Molecular weight: 5980.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5998.9 Da N = 1; 6017.0 Da N = 2; 6035.0 Da N = 3

CN358_RS25165 - Class II

Cleavage pHMM score: -0.50

RODEO score: 0

Monoisotopic mass: 4200.1 Da

Molecular weight: 4202.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4220.7 Da N = 1; 4238.7 Da N = 2; 4256.7 Da N = 3; 4274.8 Da N = 4; 4292.8 Da N = 5; 4310.8 Da N = 6; 4328.8 Da N = 7

CN358_RS25180 - Class II

Cleavage pHMM score: -1.20

RODEO score: 0

Monoisotopic mass: 4276.1 Da

Molecular weight: 4278.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4296.8 Da N = 1; 4314.8 Da N = 2; 4332.8 Da N = 3

allorf_51353_51469 - Class II

Cleavage pHMM score: -5.80

RODEO score: 0

Monoisotopic mass: 2925.5 Da

Molecular weight: 2927.7 Da

Number of bridges: 1

allorf_51406_51507 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 1942.0 Da

Molecular weight: 1943.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1961.2 Da N = 1; 1979.2 Da N = 2; 1997.2 Da N = 3; 2015.2 Da N = 4; 2033.3 Da N = 5

allorf_51931_52101 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 3435.8 Da

Molecular weight: 3437.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3455.9 Da N = 1; 3473.9 Da N = 2; 3492.0 Da N = 3

allorf_57712_57837 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 3083.6 Da

Molecular weight: 3085.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3103.6 Da N = 1

allorf_71672_71773 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 1898.0 Da

Molecular weight: 1899.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1917.3 Da N = 1

allorf_73771_73842 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 1081.5 Da

Molecular weight: 1082.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1100.3 Da N = 1; 1118.3 Da N = 2; 1136.3 Da N = 3; 1154.4 Da N = 4

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator

NZ_NTSR01000031.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 53,581 - 86,420 nt. (total: 32,840 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

CN358_RS25665: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CN358_RS25675: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

CN358_RS25680: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CN358_RS25695: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Lyases: decarboxylase

CN358_RS25690: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase

CN358_RS25700: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.67	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.67	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.70 out of 25.88

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.28 out of 29.38

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.81 out of 23.79

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.46 out of 29.38

Confidence: medium

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 25.69 out of 33.73

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.37 out of 28.14

Confidence: medium

Additional weak hits (7):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.83 out of 36.53

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.15 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.07 out of 32.74

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.31 out of 25.75

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.60 out of 30.98

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.16 out of 36.53

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.12 out of 29.65

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 53580 - 86420:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Tyr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CN358_RS25700: X - Tyr

Search NORINE for peptide: strict or relaxed

AMP-binding (477..877): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LSVAFDASIMEPVLFVGGELNAYGPTETTVCATM
Nearest Stachelhaus code(s):: Leu DAMLVGAVCK (71% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1541..1947): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: LWRYFDSSVSESDIIMGGEVNEYGPTEATVSAMY
Nearest Stachelhaus code(s):: Lys DAEDIGTVSK (62% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
HipB	Bacterial antitoxin HipB
IolR	Regulator of the inositol catabolism
PerR	Peroxide regulator
PsrA	Oleic acid responsive regulator

NZ_NTSR01000033.1 - Region 1 - NRPS-like

Download region GenBank file

Download region SVG

Location: 31,499 - 75,080 nt. (total: 43,582 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidase

CN358_RS26005: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: phosphorylase phosphotransferase

CN358_RS26015: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

CN358_RS26040: thiamine-phosphate pyrophosphorylase

smcogs: SMCOG1280: thiamine-phosphate pyrophosphorylase

Hydrolases: glucosidase

CN358_RS26010: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

Ligases: ligase

CN358_RS26055: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0001758.4	0.60	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001641.4	0.59	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0001758.4	0.60	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001641.4	0.59	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.69 out of 21.55

Confidence: strong

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 25.04 out of 26.12

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.96 out of 20.97

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.11 out of 23.05

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.78 out of 27.78

Confidence: medium

Additional weak hits (8):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.78 out of 31.73

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.11 out of 20.47

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.70 out of 25.75

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.64 out of 30.97

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.98 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 31498 - 75080:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CN358_RS26055: X

AMP-binding (225..621): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LWMPFDASVWEAALAIGGEHNVYGPTECTVVTTT
Nearest Stachelhaus code(s):: Leu DAWYLGNVVK (71% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
ArcA	Repressor of carbon oxidation
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LuxO	Repressor of luminescence
PsrA	Oleic acid responsive regulator

NZ_NTSR01000034.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 19,033 - 41,227 nt. (total: 22,195 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

CN358_RS26410: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Lyases: cyclase

CN358_RS26375: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000528.5	0.56	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000626.3	0.55	ribosomal	thuricin	Bacillus thuringiensis
BGC0001210.5	0.54	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000516.4	0.53	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000527.5	0.53	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001861.4	0.52	ribosomal	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0001863.4	0.51	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000521.3	0.51	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000528.5	0.56	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000626.3	0.55	ribosomal	thuricin	Bacillus thuringiensis
BGC0001210.5	0.54	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000516.4	0.53	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000527.5	0.53	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001861.4	0.52	ribosomal	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0001863.4	0.51	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000521.3	0.51	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CN358_RS26375

CN358_RS26340

Leader:

MKNIMRELKMEELEKHKGG

Core:

IDITQWTNTSDGGGTSLSCKELYTCWKFGVCGGENAYQAYVAYTRHC

Core with dehydrations:

IDIDhbQWDhbNDhbDhaDGGGDhbDhaLDhaCysKELYDhbCysWKFGVCysGGENAYQAYVAYDhbRHCys

antiSMASH-DB 4.0 matches for CN358_RS26340

100.0%

NZ_NTSR01000034.1:

Lanthipeptides: CN358_RS26340_lanthipeptide

1

IDITQWTNTSDGGGTSLSCKELYTCWKFGVCGGENAYQAYVAYTRHC

47

IDITQWTNTSDGGGTSLSCKELYTCWKFGVCGGENAYQAYVAYTRHC

1

IDITQWTNTSDGGGTSLSCKELYTCWKFGVCGGENAYQAYVAYTRHC

47

CN358_RS26370

Leader:

MKELLKNPVLQNKYSMKEKNPAGDLLQEVNEQEMQEVNGG

Core:

LGGAESRAIAKRMGLGDNYGTMCTVSAECMFTISCGN

Core with dehydrations:

LGGAEDhaRAIAKRMGLGDNYGDhbMCysDhbVDhaAECysMFDhbIDhaCysGN

antiSMASH-DB 4.0 matches for CN358_RS26370

100.0%

NZ_NTSR01000034.1:

Lanthipeptides: CN358_RS26370_lanthipeptide

1

LGGAESRAIAKRMGLGDNYGTMCTVSAECMFTISCGN

37

LGGAESRAIAKRMGLGDNYGTMCTVSAECMFTISCGN

1

LGGAESRAIAKRMGLGDNYGTMCTVSAECMFTISCGN

37

59.5%

NZ_CP016767.1:

Lanthipeptides: BCV50_RS18735_lanthipeptide

4

AESRAIAKRMGLGDNYGTMCTVSAECMFTISCGN

37

A S+++A R GLG+NYG CTVSAEC TISCG+

4

AYSKSLANRAGLGNNYGQYCTVSAECFGTISCGS

37

59.5%

NZ_JALAMD010000003.1and 1 other:

NZ_JALAMZ010000007.1 Lanthipeptides: MOC43_RS14030_lanthipeptide

Lanthipeptides: MOB22_RS05100_lanthipeptide

4

AESRAIAKRMGLGDNYGTMCTVSAECMFTISCGN

37

A S+++A R GLG+NYG CTVSAEC TISCG+

4

AYSKSLANRAGLGNNYGKYCTVSAECFGTISCGS

37

with 96 more sequence matches

Only the first 10 are displayed here.

54.1%

NZ_CP045267.1and 1 other:

NZ_CP045267.1 Lanthipeptides: FDZ14_RS00190_lanthipeptide

Lanthipeptides: FDZ14_RS00190_lanthipeptide

4

AESRAIAKRMGLGDNYGTMCTVSAECMFTISCGN

37

A S+ +A + GLG NYG CT SAEC TISCG+

4

AVSKTLAFQHGLGRNYGETCTWSAECAATISCGD

37

54.1%

NZ_CP048273.1and 1 other:

NZ_CP048273.1 Lanthipeptides: M654_RS18500_lanthipeptide

Lanthipeptides: M654_RS18500_lanthipeptide

4

AESRAIAKRMGLGDNYGTMCTVSAECMFTISCG

36

A S AIA+ +GLG+N+G CT SAEC T+SCG

4

AVSAAIARSVGLGNNFGKYCTWSAECAGTVSCG

36

54.1%

NZ_CP092836.1:

Lanthipeptides: MLD62_RS30280_lanthipeptide

6

SRAIAKRMGLGDNYGTMCTVSAECMFTISCGN

37

S AIA GL NYG CT SAECM T+SCG+

4

SAAIADAAGLKGNYGKFCTYSAECMGTVSCGS

35

54.1%

NZ_JAENHX010000011.1:

Lanthipeptides: JIN86_RS20375_lanthipeptide

4

AESRAIAKRMGLGDNYGTMCTVSAECMFTISC

35

A SRAIA +GLG+NYG CT SAEC T C

6

AISRAIANAVGLGNNYGMACTWSAECNGTTPC

37

54.1%

NZ_JAQFWW010000005.1:

Lanthipeptides: PDT38_RS15180_lanthipeptide

4

AESRAIAKRMGLGDNYGTMCTVSAECMFTISC

35

A+S A A+ MGLG NYG CT+SAEC TI C

5

AQSIAKARSMGLGTNYGKYCTLSAECFSTIPC

36

43.6%

NZ_LUCO01000016.1:

Lanthipeptides: BMBG_RS27155_lanthipeptide

6

SRAIAKRMGLGDNYGTMCTVSAECMFTISCG

36

S+ A GLG+NYG +CT+SAEC T CG

6

SKQAANLTGLGNNYGRVCTLSAECNGTDPCG

36

43.2%

NZ_LUCO01000016.1:

Lanthipeptides: BMBG_RS27150_lanthipeptide

6

SRAIAKRMGLGDNYGTMCTVSAECMFTIS

34

S+ A GLG+NYG CT+SAEC T S

6

SKQAANLTGLGNNYGRTCTLSAECNGTDS

34

35.1%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide

Lanthipeptides: P40081_RS01820_lanthipeptide

6

SRAIAKRMGLGDNYGTMCTVSAECM

30

S +I GLG N G +CT S ECM

9

STSIFISRGLG-NDGWVCTWSKECM

32

34.1%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25180_lanthipeptide

Lanthipeptides: CN358_RS25180_lanthipeptide

2

GGAESRAIAK---------RMGLGDNYGTMCTVSAECM

30

G AE R I +GLG+N G +CT + EC

1

GAAEPRTIGSFNSADYIKLSIGLGNN-GYICTYTVECQ

37

32.4%

NZ_AP024169.1:

Lanthipeptides: bsdtb5_RS06105_lanthipeptide

8

AIAKRMGLGDNYGTMCTVSAECMF-TISCG

36

+ A +M L G M T+S EC +SCG

3

STAIQMTLAGKCGRMPTISYECTSNNVSCG

32

MIBiG 4.0 matches for CN358_RS26370

27.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

9

IAKRMGLGDNYGTMCTVSAECM

30

I+ R+G N G CT++ ECM

6

ISCRLG---NKGAYCTLTVECM

24

21.6%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

15

LGDNYGTMCTVSAECM

30

LG+N G CT++ EC

12

LGNN-GGWCTLTKECQ

26

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

23

CTVSAECM

30

CT+S EC

28

CTLSKECQ

35

with 1 more sequence matches

10.8%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

27

AECMFTISC

35

A C T+ C

15

AYCTLTVEC

23

allorf_21436_21537

Leader:

MRWDLYSNEKSIGG

Core:

HFIYHCKSLYYGNIIYIYM

Core with dehydrations:

HFIYHCysKDhaLYYGNIIYIYM

antiSMASH-DB 4.0 matches for allorf_21436_21537

100.0%

NZ_NTSR01000034.1:

Lanthipeptides: allorf_21436_21537_lanthipeptide

1

HFIYHCKSLYYGNIIYIYM

19

HFIYHCKSLYYGNIIYIYM

1

HFIYHCKSLYYGNIIYIYM

19

allorf_26460_26624

Leader:

MQDKFQVGIIGV

Core:

ICRSFLKQIFNFIIFSSIFVISHKFCLPYSPLQLLNYFIPNI

Core with dehydrations:

ICysRDhaFLKQIFNFIIFDhaDhaIFVIDhaHKFCysLPYDhaPLQLLNYFIPNI

antiSMASH-DB 4.0 matches for allorf_26460_26624

100.0%

NZ_NTSR01000034.1:

Lanthipeptides: allorf_26460_26624_lanthipeptide

1

ICRSFLKQIFNFIIFSSIFVISHKFCLPYSPLQLLNYFIPNI

42

ICRSFLKQIFNFIIFSSIFVISHKFCLPYSPLQLLNYFIPNI

1

ICRSFLKQIFNFIIFSSIFVISHKFCLPYSPLQLLNYFIPNI

42

14.3%

NZ_CP113914.1:

Lanthipeptides: allorf_1411802_1411978_lanthipeptide

20

VISHKFCLPYSP

31

V SH C P P

1

VTSHSLCTPGCP

12

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.67 out of 20.01

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.07 out of 24.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.25 out of 24.78

Confidence: medium

Additional weak hits (1):

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.56 out of 29.65

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

CN358_RS26340 - Class II

Cleavage pHMM score: -2.20

RODEO score: 0

Monoisotopic mass: 5034.3 Da

Molecular weight: 5037.5 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 5055.5 Da N = 1; 5073.6 Da N = 2; 5091.6 Da N = 3; 5109.6 Da N = 4; 5127.6 Da N = 5

CN358_RS26370 - Class II

Cleavage pHMM score: 2.30

RODEO score: 0

Monoisotopic mass: 3705.7 Da

Molecular weight: 3708.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3726.3 Da N = 1; 3744.3 Da N = 2; 3762.3 Da N = 3

allorf_21436_21537 - Class II

Cleavage pHMM score: -4.50

RODEO score: 0

Monoisotopic mass: 2422.2 Da

Molecular weight: 2423.8 Da

Number of bridges: 1

allorf_26460_26624 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 4932.7 Da

Molecular weight: 4935.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4953.9 Da N = 1; 4972.0 Da N = 2; 4990.0 Da N = 3

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
LexA variant 2	Repressor of DNA damage response
ToxT	Regulator of MSHA biosynthesis

NZ_NTSR01000003.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 448,634 - 469,524 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

CN358_RS05265: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

CN358_RS05295: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

CN358_RS05300: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

CN358_RS05295: PT_FPPS_like

Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.32 out of 25.88

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.66 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78

Confidence: medium

Additional weak hits (1):

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.40 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator

NZ_NTSR01000040.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 38,642 - 48,971 nt. (total: 10,330 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

CN358_RS28280: aminotransferase

smcogs: SMCOG1019: aminotransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000896.5	0.29	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000721.4	0.26	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000172.5	0.23	PKS	Basiliskamide A, Basiliskamide B	Brevibacillus laterosporus PE36
BGC0000381.5	0.23	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5	0.22	NRPS	surfactin	Bacillus velezensis FZB42
BGC0000455.6	0.22	NRPS, saccharide	vancomycin	Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2	0.22	other (other)	enduracididine	uncultured bacterium
BGC0001233.5	0.22	NRPS	feglymycin	Streptomyces sp. DSM 11171
BGC0001461.5	0.21	NRPS	Actinoidin B	Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5	0.21	NRPS	decaplanin	Amycolatopsis regifaucium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000896.5	0.29	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000721.4	0.26	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000172.5	0.23	PKS	Basiliskamide A, Basiliskamide B	Brevibacillus laterosporus PE36
BGC0000381.5	0.23	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5	0.22	NRPS	surfactin	Bacillus velezensis FZB42
BGC0000455.6	0.22	NRPS, saccharide	vancomycin	Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2	0.22	other (other)	enduracididine	uncultured bacterium
BGC0001233.5	0.22	NRPS	feglymycin	Streptomyces sp. DSM 11171
BGC0001461.5	0.21	NRPS	Actinoidin B	Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5	0.21	NRPS	decaplanin	Amycolatopsis regifaucium

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.22 out of 24.78

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.87 out of 32.93

Confidence: medium

Additional weak hits (2):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.35 out of 30.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
LexA variant 2	Repressor of DNA damage response
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_NTSR01000040.1 - Region 2 - betalactone

Download region GenBank file

Download region SVG

Location: 99,726 - 124,964 nt. (total: 25,239 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CN358_RS28615: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase carboxylase transferase

CN358_RS28570: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

CN358_RS28590: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

CN358_RS28610: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Lyases: hydratase

CN358_RS28595: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

CN358_RS28585: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CN358_RS28600: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.55	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000131.5	0.46	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000706.3	0.46	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.42	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001103.5	0.42	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.55	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000131.5	0.46	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000706.3	0.46	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.42	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001103.5	0.42	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

Additional weak hits (2):

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.04 out of 30.12

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.69 out of 30.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein

NZ_NTSR01000007.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 5,472 - 71,380 nt. (total: 65,909 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CN358_RS10195: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CN358_RS10265: nucleotide sugar dehydrogenase

smcogs: SMCOG1152: nucleotide sugar dehydrogenase

Transferases: PPTase acetyltransferase acyltransferase aminotransferase

CN358_RS10140: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

CN358_RS10150: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

CN358_RS10185: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

CN358_RS10250: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

CN358_RS10270: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Hydrolases: deacetylase esterase

CN358_RS10100: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

CN358_RS10190: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

CN358_RS10275: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Isomerases: mutase

CN358_RS10070: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: ligase

CN358_RS10165: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CN358_RS10170: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CN358_RS10180: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.73	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.73	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.03 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 26.19 out of 30.25

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.20 out of 20.01

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.02 out of 23.79

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.92 out of 27.78

Confidence: medium

Additional weak hits (7):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.25 out of 30.11

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.27 out of 36.53

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.02 out of 26.85

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 5471 - 71380:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Thr) + (X - Ala) + (Ser - Leu - D-X - Glu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CN358_RS10165: Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (457..866): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

CN358_RS10170: X - Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (466..870): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: YWMTFDVSVWEWQFFSGGETNFYGPTEATIYVNA
Nearest Stachelhaus code(s):: Glu DVWHFGRINK (71% 8Å match); Gln DAWQFGLIDK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1527..1919): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: MWATFDLSVFEVNTNLAGEYNLYGPSEDTTYSTY
Nearest Stachelhaus code(s):: Ala DLFNNALTYK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

CN358_RS10180: Ser - Leu - X - Glu

Search NORINE for peptide: strict or relaxed

AMP-binding (496..901): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFTSGEINLYGPTEATVDVTY
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1558..1945): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: MWHAFDSAVQEPFAITGGDINQYGPSENTVVTTD
Nearest Stachelhaus code(s):: Pro DVQFIAQVVK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (2600..3000): X

nrpys: Gln, Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDASIQQMDILVGGEYNVYGPTECTVDATC
Nearest Stachelhaus code(s):: Gln or Glu DAQDLGVVDK (88% 8Å match); Ile DAQDLGVVDK (85% 8Å match); Gln DAQDLGVVDK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4115..4515): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDVSIQQMDMLVGGEYNVYGPTECTVDATC
Nearest Stachelhaus code(s):: Gln or Glu DAQDLGVVDK (85% 8Å match); Ile DAQDLGVVDK (82% 8Å match); Gln DAQDLGVVDK (76% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes

NZ_NTSR01000008.1 - Region 1 - NRP-metallophore,NRPS

Download region GenBank file

Download region SVG

Location: 127,568 - 179,316 nt. (total: 51,749 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CN358_RS11045: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

CN358_RS11050: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

CN358_RS11055: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

CN358_RS11120: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CN358_RS11200: Antibiotic biosynthesis monooxygenase

smcogs: SMCOG1258: Antibiotic biosynthesis monooxygenase

Transferases: PPTase

CN358_RS11155: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase protease

CN358_RS11135: isochorismatase

smcogs: SMCOG1027: isochorismatase

CN358_RS11180: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: hydratase

CN358_RS11065: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Isomerases: isomerase

CN358_RS11125: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

CN358_RS11130: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CN358_RS11140: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CN358_RS11205: Pseudouridine synthase

smcogs: SMCOG1154: Pseudouridine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	1.05	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.89	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.87	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.86	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.85	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.77	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.74	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	0.80	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.75	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.74	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.13 out of 27.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.21 out of 30.25

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.53 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.40 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.41 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.90 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.62 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.57 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.56 out of 29.38

Confidence: medium

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.57 out of 32.74

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.99 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.69 out of 32.93

Confidence: medium

Additional weak hits (7):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.83 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.49 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.05 out of 29.38

Confidence: weak

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.72 out of 18.46

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.35 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.54 out of 30.25

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 127567 - 179316:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CN358_RS11130: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SVSLYPMSSPGGALQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PMPAQGVVNK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

CN358_RS11140: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (464..864): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FAMTFDISALELQALVGGETNLYGPTETTIWSTF
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1524..1937): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQVFGGEINMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
FuR variant 1	Ferric Uptake Regulator
FuR variant 2	Ferric Uptake Regulator
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_NTSR01000009.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 58,035 - 105,051 nt. (total: 47,017 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

CN358_RS12245: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

Transferases: aminotransferase glycosyltransferase

CN358_RS12115: aminotransferase

smcogs: SMCOG1019: aminotransferase

CN358_RS12260: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Hydrolases: esterase glucanase hydrolase

CN358_RS12110: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

CN358_RS12150: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs: SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

CN358_RS12160: Pullulanase, type I

smcogs: SMCOG1297: Pullulanase, type I

CN358_RS12180: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: decarboxylase

CN358_RS12175: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase

CN358_RS12170: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.72	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.72	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.66 out of 25.88

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.58 out of 20.97

Confidence: medium

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 28.23 out of 31.73

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25

Confidence: medium

Additional weak hits (6):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.36 out of 33.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.46 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.76 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.69 out of 31.73

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.02 out of 32.74

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.63 out of 29.65

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 58034 - 105051:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CN358_RS12170: X - Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (268..658): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FVMAFDISLLELESLLAGELNIYGPTETTICATV
Nearest Stachelhaus code(s):: Ala DILICALICK (44% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1305..1685): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDISFDLSVYDGNTLHSGDVSLGGATEASIWSIY
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CcpA	Catabolite control protein A
ColR	Phenol-responsive regulator
HexR	Glucose-responsive regulator
PsrA	Oleic acid responsive regulator

NZ_NTSR01000009.1 - Region 2 - RiPP-like

Download region GenBank file

Download region SVG

Location: 124,247 - 134,507 nt. (total: 10,261 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

CN358_RS12425: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Similar gene clusters

No matches found.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.32 out of 26.06

Confidence: strong

Additional weak hits (1):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 36.53

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes