GCF_002562205.1 - 14 region(s)

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Location: 340,509 - 362,362 nt. (total: 21,854 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CN427_RS14620: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

CN427_RS14625: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: lyase

CN427_RS14595: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.52	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000916.5	0.46	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000812.3	0.45	other (other)	huperzine A	Shiraia sp. slf14
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001197.5	0.42	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002138.2	0.40	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.52	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000916.5	0.46	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000812.3	0.45	other (other)	huperzine A	Shiraia sp. slf14
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001197.5	0.42	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002138.2	0.40	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

CN427_RS14635: T2TS

Domain 1 (4 - 614): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 26.42 out of 30.22

Confidence: medium

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
ClgR	Caseinolytic protease gene regulator

NZ_NTWJ01000012.1 - Region 1 - NRPS

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Location: 21,076 - 86,984 nt. (total: 65,909 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

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KnownClusterBlast

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TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase acetyltransferase acyltransferase

CN427_RS15000: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

CN427_RS15010: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

CN427_RS15045: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: deacetylase esterase

CN427_RS14955: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

CN427_RS15050: thioesterase

smcogs: SMCOG1004: thioesterase

Isomerases: mutase

CN427_RS14925: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: ligase

CN427_RS15025: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CN427_RS15030: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CN427_RS15040: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Translocases: permease

CN427_RS15090: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

CN427_RS15105: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.73	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.73	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.03 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.01 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06

Confidence: medium

Additional weak hits (4):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.64 out of 31.73

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.08 out of 36.54

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.14 out of 22.40

Confidence: weak

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 21075 - 86984:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Thr) + (X - Ala) + (Ser - Leu - D-X - Glu)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

CN427_RS15025: Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (457..866): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

CN427_RS15030: X - Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (466..870): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: YWMTFDVSVWEWQFFSGGETNFYGPTEATIYVNA
Nearest Stachelhaus code(s):: Glu DVWHFGRINK (71% 8Å match); Gln DAWQFGLIDK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1527..1919): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: MWATFDLSVFEVNTNLAGEFNLYGPSEDTTYSTY
Nearest Stachelhaus code(s):: Ala DLFNNALTYK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

CN427_RS15040: Ser - Leu - X - Glu

Search NORINE for peptide: strict or relaxed

AMP-binding (496..901): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFTSGEINLYGPTEATVDVTY
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1558..1945): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: MWHAFDSAVQEPFAITGGDINQYGPSENTVVTTD
Nearest Stachelhaus code(s):: Pro DVQFIAQVVK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (2600..3000): X

nrpys: Gln, Glu, Ile

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDASIQQMDILVGGEYNVYGPTECTVDATY
Nearest Stachelhaus code(s):: Gln or Glu DAQDLGVVDK (85% 8Å match); Ile DAQDLGVVDK (85% 8Å match); Gln DAQDLGVVDK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4115..4515): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDVSIQQMDMLVGGEYNVYGPTECTVDATC
Nearest Stachelhaus code(s):: Gln or Glu DAQDLGVVDK (85% 8Å match); Ile DAQDLGVVDK (82% 8Å match); Gln DAQDLGVVDK (76% 8Å match)
Stachelhaus code match:: 90% (moderate)

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator
MogR	Repressor of flagellar motility genes

NZ_NTWJ01000015.1 - Region 1 - CDPS

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Location: 14,165 - 34,884 nt. (total: 20,720 nt) Show pHMM detection rules used

CDPS: CDPS

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

CN427_RS15985: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Hydrolases: hydrolase

CN427_RS15960: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

CN427_RS15965: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002103.2	0.71	other (other)	pulcherriminic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0001286.3	0.50	other (other)	itaconic acid	Ustilago maydis
BGC0001336.5	0.40	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000470.6	0.39	ribosomal	bottromycin D	Streptomyces sp. WMMB272
BGC0001529.5	0.34	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0000306.5	0.33	NRPS	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0001334.5	0.32	other (other)	caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G	Streptomyces uncialis
BGC0000397.5	0.32	NRPS	nostocyclopeptide A2	Nostoc sp. ATCC 53789
BGC0000444.5	0.32	NRPS	thaxtomin A	Streptomyces turgidiscabies Car8
BGC0001337.5	0.31	other (other)	lazarimide A, lazarimide B, lazarimide C	uncultured bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002103.2	0.71	other (other)	pulcherriminic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0001286.3	0.50	other (other)	itaconic acid	Ustilago maydis
BGC0001336.5	0.40	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000470.6	0.39	ribosomal	bottromycin D	Streptomyces sp. WMMB272
BGC0001529.5	0.34	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0000306.5	0.33	NRPS	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0001334.5	0.32	other (other)	caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G	Streptomyces uncialis
BGC0000397.5	0.32	NRPS	nostocyclopeptide A2	Nostoc sp. ATCC 53789
BGC0000444.5	0.32	NRPS	thaxtomin A	Streptomyces turgidiscabies Car8
BGC0001337.5	0.31	other (other)	lazarimide A, lazarimide B, lazarimide C	uncultured bacterium

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.34 out of 20.97

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.25 out of 20.97

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.90 out of 27.78

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.68 out of 24.78

Confidence: medium

Additional weak hits (4):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.40 out of 20.01

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.29 out of 36.54

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 19.98 out of 30.22

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 25.50 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response

NZ_NTWJ01000015.1 - Region 2 - NRPS

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Location: 412,680 - 444,125 nt. (total: 31,446 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CN427_RS18085: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: aminotransferase

CN427_RS18090: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: esterase glucanase hydrolase

CN427_RS18080: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

CN427_RS18125: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs: SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

CN427_RS18135: Pullulanase, type I

smcogs: SMCOG1297: Pullulanase, type I

CN427_RS18155: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: decarboxylase

CN427_RS18150: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase

CN427_RS18145: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.72	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.61	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.72	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.61	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.66 out of 25.88

Confidence: medium

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 28.23 out of 31.73

Confidence: medium

Additional weak hits (4):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.36 out of 33.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.46 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.76 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.69 out of 31.73

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 412679 - 444125:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Cys)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

CN427_RS18145: X - Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (268..658): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FVMAFDISLLELESLLAGELNIYGPTETTICATV
Nearest Stachelhaus code(s):: Ala DILICALICK (44% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1305..1685): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDISFDLSVYDGNTLHSGDVSLGGATEASIWSIY
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
HexR	Glucose-responsive regulator
PsrA	Oleic acid responsive regulator

NZ_NTWJ01000021.1 - Region 1 - NRPS-like

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Location: 76,232 - 119,813 nt. (total: 43,582 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidase

CN427_RS20585: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: phosphorylase phosphotransferase

CN427_RS20550: thiamine-phosphate pyrophosphorylase

smcogs: SMCOG1280: thiamine-phosphate pyrophosphorylase

CN427_RS20575: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Hydrolases: glucosidase

CN427_RS20580: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

Ligases: ligase

CN427_RS20535: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0001758.4	0.60	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0001758.4	0.60	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.69 out of 27.55

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.83 out of 27.78

Confidence: strong

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.18 out of 23.79

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.99 out of 29.38

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.69 out of 21.55

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19

Confidence: strong

Additional weak hits (11):

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.06 out of 29.72

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.70 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.72 out of 32.74

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.11 out of 20.47

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.78 out of 31.73

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.62 out of 29.25

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.98 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 76231 - 119813:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

CN427_RS20535: X

AMP-binding (225..621): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LWMPFDASVWEAALAIGGEHNVYGPTECTVVTTT
Nearest Stachelhaus code(s):: Leu DAWYLGNVVK (71% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
PsrA	Oleic acid responsive regulator
ZuR variant 1	Zinc-responsive repressor

NZ_NTWJ01000025.1 - Region 1 - RiPP-like

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Location: 88,571 - 98,831 nt. (total: 10,261 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

CN427_RS25655: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Similar gene clusters

No matches found.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

NZ_NTWJ01000036.1 - Region 1 - NI-siderophore

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Location: 3,967 - 35,674 nt. (total: 31,708 nt) Show pHMM detection rules used

Region on contig edge.

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

CN427_RS27155: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: deacetylase

CN427_RS27090: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: ligase synthase

CN427_RS27050: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

CN427_RS27120: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000942.4	0.88	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0002469.2	0.54	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001572.3	0.51	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002692.2	0.50	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0002620.2	0.50	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0001713.5	0.48	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002464.3	0.48	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002633.2	0.47	other (other)	schizokinen	Leptolyngbya sp. PCC 7376

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000942.4	0.88	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0002469.2	0.54	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001572.3	0.51	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002692.2	0.50	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0002620.2	0.50	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0001713.5	0.48	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002464.3	0.48	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002633.2	0.47	other (other)	schizokinen	Leptolyngbya sp. PCC 7376

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.03 out of 20.97

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.38 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.93 out of 28.19

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.13 out of 18.16

Confidence: strong

Additional weak hits (4):

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.50 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.66 out of 32.74

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.60 out of 36.54

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
FuR variant 1	Ferric Uptake Regulator
ZuR variant 1	Zinc-responsive repressor

NZ_NTWJ01000003.1 - Region 1 - azole-containing-RiPP

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Location: 100,999 - 124,505 nt. (total: 23,507 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

CN427_RS02080: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: methyltransferase

CN427_RS02065: methyltransferase

smcogs: SMCOG1089: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.44	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0002013.4	0.44	ribosomal	curacozole	Streptomyces curacoi
BGC0000607.5	0.43	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001535.3	0.43	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001146.5	0.41	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001860.4	0.39	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0000628.4	0.38	ribosomal	lactocillin	Lactobacillus paragasseri JV-V03
BGC0001145.5	0.38	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.44	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0002013.4	0.44	ribosomal	curacozole	Streptomyces curacoi
BGC0000607.5	0.43	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001535.3	0.43	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001146.5	0.41	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001860.4	0.39	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0000628.4	0.38	ribosomal	lactocillin	Lactobacillus paragasseri JV-V03
BGC0001145.5	0.38	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.63 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.38 out of 27.78

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.04 out of 23.79

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.57 out of 28.19

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.43 out of 32.93

Confidence: medium

Additional weak hits (3):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.85 out of 29.38

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.76 out of 30.12

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.41 out of 30.12

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Heterocycloanthracin_C_RRE; Location: 0 - 100; Score: 183.5; RRE type: Thiopeptide_F_RRE; Location: 10 - 89; Score: 40.6

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
LexA variant 3	Repressor of DNA damage response
ZuR variant 1	Zinc-responsive repressor

Core peptide predictions

No core peptides found.

NZ_NTWJ01000043.1 - Region 1 - lanthipeptide-class-ii

BGC0002120.3 (NQE92413.1):

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Location: 23,752 - 43,663 nt. (total: 19,912 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

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SubClusterBlast

Lanthipeptides

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Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

CN427_RS29335: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

CN427_RS29350: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

CN427_RS29375: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.60	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000517.4	0.57	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000525.5	0.54	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002110.3	0.53	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3	0.52	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0001229.4	0.52	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000555.3	0.51	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.60	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000517.4	0.57	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000525.5	0.54	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002110.3	0.53	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3	0.52	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0001229.4	0.52	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000555.3	0.51	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CN427_RS29350

CN427_RS29300

Leader:

MLLSDNDIKRELIKGENITIYPLNIKGSSINLTASKYA

Core:

WKVSDRETAIIEDKIAIPPNEAVCIYTQ

Core with dehydrations:

WKVDhaDREDhbAIIEDKIAIPPNEAVCysIYDhbQ

antiSMASH-DB 4.0 matches for CN427_RS29300

100.0%

NZ_NTWJ01000043.1:

Lanthipeptides: CN427_RS29300_lanthipeptide

1

WKVSDRETAIIEDKIAIPPNEAVCIYTQ

28

WKVSDRETAIIEDKIAIPPNEAVCIYTQ

1

WKVSDRETAIIEDKIAIPPNEAVCIYTQ

28

89.3%

NZ_JAMXMK010000009.1:

Lanthipeptides: NGM22_RS28145_lanthipeptide

2

KVSDRETAIIEDKIAIPPNEAVCIYTQ

28

KVSDRETA+IEDKI IPPNEAVCIYTQ

2

KVSDRETAVIEDKIVIPPNEAVCIYTQ

28

27.5%

NZ_CP054019.1and 1 other:

NZ_CP070326.1 Lanthipeptides: allorf_7802948_7803130_lanthipeptide

Lanthipeptides: allorf_9072976_9073158_lanthipeptide

6

RETAIIEDKIAIP---PNEAVCIYT

27

R TA+ ++A P PN AVC T

14

RVTAMRSLRMARPAHRPNFAVCPGT

38

with 1 more sequence matches

10.7%

NZ_CM000743.1:

Lanthipeptides: allorf_5714238_5714447_lanthipeptide

12

EDKIAIPPNEAVCIY

26

E+K PP + C Y

34

ENKRESPPTFSFCFY

48

CN427_RS29340

Leader:

MVEKEKMSKVIGVVDEHELKMLSGA

Core:

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

Core with dehydrations:

AEVEDhbRDhaDhaLPCysAGLDhbVAVGDhbWVFQDhbDhaEKDhbCysPDhbLACysDhaKACys

antiSMASH-DB 4.0 matches for CN427_RS29340

100.0%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29340_lanthipeptide

Lanthipeptides: CN427_RS29340_lanthipeptide

1

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

1

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

89.7%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS31525_lanthipeptide

Lanthipeptides: CN427_RS31525_lanthipeptide

1

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

AEVETRSS+PC LTVAVGTWVFQTS+KTCPTLACSKAC

1

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

45.2%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

1

AEVETRSSLPCA--GLTVAVGTWVFQTSEKTCPTLACSKAC

39

AEV R+++PCA G TV + + F S ++CPT ACS C

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

with 53 more sequence matches

Only the first 10 are displayed here.

41.0%

NZ_BMFU01000012.1and 1 other:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25390_lanthipeptide

Lanthipeptides: IEW26_RS25390_lanthipeptide

2

EVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

EV+ SS PCA + V W S +CP+ ACS C

2

EVQAASSWPCA-IVPPVVIWTITDSANSCPSTACSSRC

38

41.0%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

5

TRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

T + P + VAV +V S+KTCPT AC++AC

1

TTPATPATPVIVAVSAYV---SDKTCPTTACTRAC

32

41.0%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: HNR77_RS17300_lanthipeptide

Lanthipeptides: HNR77_RS17300_lanthipeptide

2

EVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

EV+ SS PCA + V W S +CP+ ACS C

2

EVQVASSWPCA-IVPPVVIWTITDSANSCPSTACSSRC

38

41.0%

NZ_JAHXMW010000012.1and 3 others:

NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23840_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptide

Lanthipeptides: KZX51_RS23840_lanthipeptide

2

EVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

EV+ SS PCA + V W S +CP+ ACS C

2

EVQVASSWPCA-IVPPVLIWTITDSANSCPSTACSSRC

38

38.5%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide

Lanthipeptides: BALI_RS00915_lanthipeptide

5

TRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

T SSLPC L AV W CP+ AC+ C

8

TPSSLPCGTLVTAV--W--------CPSNACTSDC

32

38.5%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00390_lanthipeptide

Lanthipeptides: CWT12_RS00390_lanthipeptide

5

TRSSLPCA-GLTVAVGTWVFQTSEKTCPTLACSKAC

39

T SS PC G+T V CPT ACS C

3

TPSSWPCGIGITTTV-----------CPTAACSSKC

27

38.5%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08310_lanthipeptide

Lanthipeptides: BJR39_RS08310_lanthipeptide

10

PCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

P A L A G V S +TCPT AC++AC

3

PTALLAGAAGGVVTYVSNQTCPTTACTRAC

32

38.5%

NZ_JAENHN010000066.1and 1 other:

NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24410_lanthipeptide

Lanthipeptides: JHL18_RS24410_lanthipeptide

7

SSLPCA--GLTVAVGTWVFQTSEKTCPTLACSKAC

39

++L CA GLTV V T E CP+ AC+ C

3

TTLACAITGLTVIVVT------EVACPSKACTGYC

31

38.5%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07280_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptide

Lanthipeptides: MOK21_RS07280_lanthipeptide

1

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

EV RSS C + V W S +CP+ ACS C

1

GEVNPRSSWGCV---IDVTIWTITDSMNSCPSTACSTRC

36

38.5%

NZ_JALIRS010000003.1and 7 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07275_lanthipeptideNZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07270_lanthipeptideNZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07270_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptide

Lanthipeptides: MOK21_RS07275_lanthipeptide

1

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

EV RSS C V V + S +CP+ ACS C

1

GEVNPRSSWGCV---VQVTIYTISDSMNSCPSTACSTRC

36

MIBiG 4.0 matches for CN427_RS29340

11.8%

Lanthipeptide: nocathioamide A

4

ETRSSLPC

11

T SSLPC

41

HTLSSLPC

48

CN427_RS31525

Leader:

MSKIGIVDEQELKMLSGA

Core:

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

Core with dehydrations:

AEVEDhbRDhaDhaVPCysVDhaLDhbVAVGDhbWVFQDhbDhaDKDhbCysPDhbLACysDhaKACys

antiSMASH-DB 4.0 matches for CN427_RS31525

100.0%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS31525_lanthipeptide

Lanthipeptides: CN427_RS31525_lanthipeptide

1

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

1

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

89.7%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29340_lanthipeptide

Lanthipeptides: CN427_RS29340_lanthipeptide

1

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

AEVETRSS+PC LTVAVGTWVFQTS+KTCPTLACSKAC

1

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

43.6%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

5

TRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

T + P + VAV +V SDKTCPT AC++AC

1

TTPATPATPVIVAVSAYV---SDKTCPTTACTRAC

32

with 55 more sequence matches

Only the first 10 are displayed here.

42.9%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

1

AEVETRSSVPCV--SLTVAVGTWVFQTSDKTCPTLACSKAC

39

AEV R++VPC TV + + F S ++CPT ACS C

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

41.0%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07280_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptide

Lanthipeptides: MOK21_RS07280_lanthipeptide

1

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

EV RSS CV + V W S +CP+ ACS C

1

GEVNPRSSWGCV---IDVTIWTITDSMNSCPSTACSTRC

36

41.0%

NZ_JALIRS010000003.1and 7 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07275_lanthipeptideNZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07270_lanthipeptideNZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07270_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptide

Lanthipeptides: MOK21_RS07275_lanthipeptide

1

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

EV RSS CV V V + S +CP+ ACS C

1

GEVNPRSSWGCV---VQVTIYTISDSMNSCPSTACSTRC

36

38.5%

NZ_BLIS01000009.1and 1 other:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

5

TRSSVPCVSLTVAVGTWVFQT----SDKTCPTLACSKAC

39

T + P T A+G V S TCPT AC++AC

1

TTPASPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

39

38.5%

NZ_BMFU01000012.1and 1 other:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25390_lanthipeptide

Lanthipeptides: IEW26_RS25390_lanthipeptide

2

EVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

EV+ SS PC ++ V W S +CP+ ACS C

2

EVQAASSWPC-AIVPPVVIWTITDSANSCPSTACSSRC

38

38.5%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: HNR77_RS17300_lanthipeptide

Lanthipeptides: HNR77_RS17300_lanthipeptide

2

EVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

EV+ SS PC ++ V W S +CP+ ACS C

2

EVQVASSWPC-AIVPPVVIWTITDSANSCPSTACSSRC

38

38.5%

NZ_JAHXMW010000012.1and 3 others:

NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23840_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptide

Lanthipeptides: KZX51_RS23840_lanthipeptide

2

EVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

EV+ SS PC ++ V W S +CP+ ACS C

2

EVQVASSWPC-AIVPPVLIWTITDSANSCPSTACSSRC

38

35.9%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide

Lanthipeptides: BALI_RS00915_lanthipeptide

5

TRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

T SS+PC +L AV W CP+ AC+ C

8

TPSSLPCGTLVTAV--W--------CPSNACTSDC

32

35.9%

NZ_CP017953.1and 15 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide

Lanthipeptides: BAMY_RS16390_lanthipeptide

8

SVPCVSLTVAVG----TWVFQTSDKTCPTLACSKAC

39

+ P V LT +G T+ S +CPT AC+K C

1

ATPTVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

36

35.9%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12785_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15570_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15570_lanthipeptide

Lanthipeptides: GTU71_RS12785_lanthipeptide

12

VSLTVAVGTWV--FQTSDKTCPTLACSKAC

39

VS TVA T V TS CPT +C+ C

7

VSGTVASATAVSALVTSSGLCPTFSCTGEC

36

CN427_RS29360

Leader:

MNNEMKSWKNPYFRNSQNHATNLPIEDPLMELAEEDIKSINGG

CN427_RS29365

Leader:

MNNELKSWKNPYLRNSQNHATNLPIEDPLMELAEEDIKSINGG

CN427_RS29370

Leader:

MNNELKSWKNPYLRNSQNHATNLPIEDPLMELAEEDIKSINGG

Shared core:

VEPRGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRKGSCA

Core with dehydrations:

VEPRGWGDVLDhbDhbLLCysFVGDhaYDhbLGNDGIMCysDhbDhbDhaYECysQRKGDhaCysA

antiSMASH-DB 4.0 matches for CN427_RS29360

100.0%

NZ_NTWJ01000043.1and 5 others:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29365_lanthipeptideNZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29360_lanthipeptideNZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29370_lanthipeptideNZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29365_lanthipeptideNZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29360_lanthipeptide

Lanthipeptides: CN427_RS29370_lanthipeptide

1

VEPRGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRKGSCA

42

VEPRGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRKGSCA

1

VEPRGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRKGSCA

42

42.9%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

1

VEPRGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

V+ R +LT+L C SY LGN G +CT + ECQ+K

1

VQERWAETILTSLACAAASYILGNPGHVCTLTVECQKK

38

40.5%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

4

RGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

+GWG V+++L C+ SY LGN+G CT + ECQ

2

QGWGTVMSSLSCYGASYVLGNNGNFCTATAECQNN

36

with 101 more sequence matches

Only the first 10 are displayed here.

40.5%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

6

WGDVLTTLLCFVGSYTLGNDGIMCTTSYEC

35

WG VLTTL C SY LG+ G +CT + EC

3

WGTVLTTLACLGASYALGDKGQVCTATVEC

32

40.5%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

4

RGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

+G G +TTL C+ S+ LGNDG CT + ECQ

1

QGIGTTVTTLSCYGVSWALGNDGNFCTATVECQSN

35

40.5%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: GCN81_RS29300_lanthipeptide

4

RGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

+GWG L++L C+ SY LGN+G CT + ECQ

2

QGWGTTLSSLSCYGASYVLGNNGNFCTATAECQSN

36

38.1%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

4

RGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

+GWG ++++L C+ SY LGN+G CT + ECQ

2

QGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNN

36

38.1%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide

Lanthipeptides: allorf_027480_027638_lanthipeptide

1

VEPRGWGDVL-TTLLCFVGSYTLGNDGIMCTTSYECQRK

38

+P+ W +V+ T+L C SY +GN G +CT + ECQ+

3

AQPQ-WAEVIITSLACAAASYFMGNPGHVCTLTVECQKS

40

35.7%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

5

GWGDVLTTLL-CFVGSYTLGNDGIMCTTSYECQ

36

GW V ++ C + S LGNDG +CT + ECQ

1

GWTGVAKSITSCSLLSIGLGNDGWVCTWTAECQ

33

35.7%

NZ_BCEY01000006.1and 1 other:

NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide

Lanthipeptides: GOZ53_RS01290_lanthipeptide

5

GWGDVLTTLL-CFVGSYTLGNDGIMCTTSYECQ

36

GW V +++ C + S+ LGNDG +CT + ECQ

1

GWTGVAKSIVSCSLISFALGNDGWICTWTAECQ

33

35.7%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09360_lanthipeptide

Lanthipeptides: AOX59_RS09360_lanthipeptide

1

VEPRGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

V+P+ LT C S +GNDG +CT + ECQ

2

VDPQT---ALTYSTCHWISPAMGNDGHLCTATVECQPN

36

35.7%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

6

WGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

WG +LTTL C S +G+ G +CT + ECQ

3

WGTLLTTLSCLAASIMIGDKGQVCTGTVECQNN

35

33.3%

NZ_BMFU01000012.1and 5 others:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide

Lanthipeptides: IEW26_RS25375_lanthipeptide

2

EPRGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

+P ++T+L C SY +GN G +CT + ECQ+

4

QPEWVEVIITSLACAAASYFMGNPGHVCTLTVECQKS

40

MIBiG 4.0 matches for CN427_RS29360

26.2%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

16

FVGSYTLGNDGIMCTTSYECQ

36

F S LGN+G CT + ECQ

6

FSLSNALGNNGGWCTLTKECQ

26

19.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

22

LGNDGIMCTTSYECQ

36

LGN G CT + EC

10

LGNKGAYCTLTVECM

24

14.3%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

29

CTTSYECQ

36

CT S ECQ

28

CTLSKECQ

35

allorf_39377_39460

Leader:

MSFQKCIFNINNNYAFM

Core:

CNYDSNVMPF

Core with dehydrations:

CysNYDDhaNVMPF

antiSMASH-DB 4.0 matches for allorf_39377_39460

100.0%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: allorf_39377_39460_lanthipeptide

Lanthipeptides: allorf_39377_39460_lanthipeptide

1

CNYDSNVMPF

10

CNYDSNVMPF

1

CNYDSNVMPF

10

Lanthipeptide(s) for CN427_RS29375

CN427_RS29340

Leader:

MVEKEKMSKVIGVVDEHELKMLSGA

Core:

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

Core with dehydrations:

AEVEDhbRDhaDhaLPCysAGLDhbVAVGDhbWVFQDhbDhaEKDhbCysPDhbLACysDhaKACys

antiSMASH-DB 4.0 matches for CN427_RS29340

100.0%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29340_lanthipeptide

Lanthipeptides: CN427_RS29340_lanthipeptide

1

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

1

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

89.7%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS31525_lanthipeptide

Lanthipeptides: CN427_RS31525_lanthipeptide

1

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

AEVETRSS+PC LTVAVGTWVFQTS+KTCPTLACSKAC

1

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

45.2%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

1

AEVETRSSLPCA--GLTVAVGTWVFQTSEKTCPTLACSKAC

39

AEV R+++PCA G TV + + F S ++CPT ACS C

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

with 53 more sequence matches

Only the first 10 are displayed here.

41.0%

NZ_BMFU01000012.1and 1 other:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25390_lanthipeptide

Lanthipeptides: IEW26_RS25390_lanthipeptide

2

EVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

EV+ SS PCA + V W S +CP+ ACS C

2

EVQAASSWPCA-IVPPVVIWTITDSANSCPSTACSSRC

38

41.0%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

5

TRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

T + P + VAV +V S+KTCPT AC++AC

1

TTPATPATPVIVAVSAYV---SDKTCPTTACTRAC

32

41.0%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: HNR77_RS17300_lanthipeptide

Lanthipeptides: HNR77_RS17300_lanthipeptide

2

EVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

EV+ SS PCA + V W S +CP+ ACS C

2

EVQVASSWPCA-IVPPVVIWTITDSANSCPSTACSSRC

38

41.0%

NZ_JAHXMW010000012.1and 3 others:

NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23840_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptide

Lanthipeptides: KZX51_RS23840_lanthipeptide

2

EVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

EV+ SS PCA + V W S +CP+ ACS C

2

EVQVASSWPCA-IVPPVLIWTITDSANSCPSTACSSRC

38

38.5%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide

Lanthipeptides: BALI_RS00915_lanthipeptide

5

TRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

T SSLPC L AV W CP+ AC+ C

8

TPSSLPCGTLVTAV--W--------CPSNACTSDC

32

38.5%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00390_lanthipeptide

Lanthipeptides: CWT12_RS00390_lanthipeptide

5

TRSSLPCA-GLTVAVGTWVFQTSEKTCPTLACSKAC

39

T SS PC G+T V CPT ACS C

3

TPSSWPCGIGITTTV-----------CPTAACSSKC

27

38.5%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08310_lanthipeptide

Lanthipeptides: BJR39_RS08310_lanthipeptide

10

PCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

P A L A G V S +TCPT AC++AC

3

PTALLAGAAGGVVTYVSNQTCPTTACTRAC

32

38.5%

NZ_JAENHN010000066.1and 1 other:

NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24410_lanthipeptide

Lanthipeptides: JHL18_RS24410_lanthipeptide

7

SSLPCA--GLTVAVGTWVFQTSEKTCPTLACSKAC

39

++L CA GLTV V T E CP+ AC+ C

3

TTLACAITGLTVIVVT------EVACPSKACTGYC

31

38.5%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07280_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptide

Lanthipeptides: MOK21_RS07280_lanthipeptide

1

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

EV RSS C + V W S +CP+ ACS C

1

GEVNPRSSWGCV---IDVTIWTITDSMNSCPSTACSTRC

36

38.5%

NZ_JALIRS010000003.1and 7 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07275_lanthipeptideNZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07270_lanthipeptideNZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07270_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptide

Lanthipeptides: MOK21_RS07275_lanthipeptide

1

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

EV RSS C V V + S +CP+ ACS C

1

GEVNPRSSWGCV---VQVTIYTISDSMNSCPSTACSTRC

36

MIBiG 4.0 matches for CN427_RS29340

11.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

4

ETRSSLPC

11

T SSLPC

41

HTLSSLPC

48

CN427_RS31525

Leader:

MSKIGIVDEQELKMLSGA

Core:

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

Core with dehydrations:

AEVEDhbRDhaDhaVPCysVDhaLDhbVAVGDhbWVFQDhbDhaDKDhbCysPDhbLACysDhaKACys

antiSMASH-DB 4.0 matches for CN427_RS31525

100.0%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS31525_lanthipeptide

Lanthipeptides: CN427_RS31525_lanthipeptide

1

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

1

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

89.7%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29340_lanthipeptide

Lanthipeptides: CN427_RS29340_lanthipeptide

1

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

AEVETRSS+PC LTVAVGTWVFQTS+KTCPTLACSKAC

1

AEVETRSSLPCAGLTVAVGTWVFQTSEKTCPTLACSKAC

39

43.6%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

5

TRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

T + P + VAV +V SDKTCPT AC++AC

1

TTPATPATPVIVAVSAYV---SDKTCPTTACTRAC

32

with 55 more sequence matches

Only the first 10 are displayed here.

42.9%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

1

AEVETRSSVPCV--SLTVAVGTWVFQTSDKTCPTLACSKAC

39

AEV R++VPC TV + + F S ++CPT ACS C

1

AEVNPRTTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

41.0%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07280_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06785_lanthipeptide

Lanthipeptides: MOK21_RS07280_lanthipeptide

1

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

EV RSS CV + V W S +CP+ ACS C

1

GEVNPRSSWGCV---IDVTIWTITDSMNSCPSTACSTRC

36

41.0%

NZ_JALIRS010000003.1and 7 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07275_lanthipeptideNZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07270_lanthipeptideNZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07270_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06790_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06795_lanthipeptide

Lanthipeptides: MOK21_RS07275_lanthipeptide

1

AEVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

EV RSS CV V V + S +CP+ ACS C

1

GEVNPRSSWGCV---VQVTIYTISDSMNSCPSTACSTRC

36

38.5%

NZ_BLIS01000009.1and 1 other:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

5

TRSSVPCVSLTVAVGTWVFQT----SDKTCPTLACSKAC

39

T + P T A+G V S TCPT AC++AC

1

TTPASPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

39

38.5%

NZ_BMFU01000012.1and 1 other:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25390_lanthipeptide

Lanthipeptides: IEW26_RS25390_lanthipeptide

2

EVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

EV+ SS PC ++ V W S +CP+ ACS C

2

EVQAASSWPC-AIVPPVVIWTITDSANSCPSTACSSRC

38

38.5%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: HNR77_RS17300_lanthipeptide

Lanthipeptides: HNR77_RS17300_lanthipeptide

2

EVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

EV+ SS PC ++ V W S +CP+ ACS C

2

EVQVASSWPC-AIVPPVVIWTITDSANSCPSTACSSRC

38

38.5%

NZ_JAHXMW010000012.1and 3 others:

NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23840_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24460_lanthipeptide

Lanthipeptides: KZX51_RS23840_lanthipeptide

2

EVETRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

EV+ SS PC ++ V W S +CP+ ACS C

2

EVQVASSWPC-AIVPPVLIWTITDSANSCPSTACSSRC

38

35.9%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide

Lanthipeptides: BALI_RS00915_lanthipeptide

5

TRSSVPCVSLTVAVGTWVFQTSDKTCPTLACSKAC

39

T SS+PC +L AV W CP+ AC+ C

8

TPSSLPCGTLVTAV--W--------CPSNACTSDC

32

35.9%

NZ_CP017953.1and 15 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide

Lanthipeptides: BAMY_RS16390_lanthipeptide

8

SVPCVSLTVAVG----TWVFQTSDKTCPTLACSKAC

39

+ P V LT +G T+ S +CPT AC+K C

1

ATPTVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

36

35.9%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12785_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15570_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15570_lanthipeptide

Lanthipeptides: GTU71_RS12785_lanthipeptide

12

VSLTVAVGTWV--FQTSDKTCPTLACSKAC

39

VS TVA T V TS CPT +C+ C

7

VSGTVASATAVSALVTSSGLCPTFSCTGEC

36

CN427_RS29360

Leader:

MNNEMKSWKNPYFRNSQNHATNLPIEDPLMELAEEDIKSINGG

CN427_RS29365

Leader:

MNNELKSWKNPYLRNSQNHATNLPIEDPLMELAEEDIKSINGG

CN427_RS29370

Leader:

MNNELKSWKNPYLRNSQNHATNLPIEDPLMELAEEDIKSINGG

Shared core:

VEPRGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRKGSCA

Core with dehydrations:

VEPRGWGDVLDhbDhbLLCysFVGDhaYDhbLGNDGIMCysDhbDhbDhaYECysQRKGDhaCysA

antiSMASH-DB 4.0 matches for CN427_RS29360

100.0%

NZ_NTWJ01000043.1and 5 others:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29365_lanthipeptideNZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29360_lanthipeptideNZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29370_lanthipeptideNZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29365_lanthipeptideNZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29360_lanthipeptide

Lanthipeptides: CN427_RS29370_lanthipeptide

1

VEPRGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRKGSCA

42

VEPRGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRKGSCA

1

VEPRGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRKGSCA

42

42.9%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

1

VEPRGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

V+ R +LT+L C SY LGN G +CT + ECQ+K

1

VQERWAETILTSLACAAASYILGNPGHVCTLTVECQKK

38

40.5%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

4

RGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

+GWG V+++L C+ SY LGN+G CT + ECQ

2

QGWGTVMSSLSCYGASYVLGNNGNFCTATAECQNN

36

with 101 more sequence matches

Only the first 10 are displayed here.

40.5%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

6

WGDVLTTLLCFVGSYTLGNDGIMCTTSYEC

35

WG VLTTL C SY LG+ G +CT + EC

3

WGTVLTTLACLGASYALGDKGQVCTATVEC

32

40.5%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

4

RGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

+G G +TTL C+ S+ LGNDG CT + ECQ

1

QGIGTTVTTLSCYGVSWALGNDGNFCTATVECQSN

35

40.5%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: GCN81_RS29300_lanthipeptide

4

RGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

+GWG L++L C+ SY LGN+G CT + ECQ

2

QGWGTTLSSLSCYGASYVLGNNGNFCTATAECQSN

36

38.1%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

4

RGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

+GWG ++++L C+ SY LGN+G CT + ECQ

2

QGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNN

36

38.1%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide

Lanthipeptides: allorf_027480_027638_lanthipeptide

1

VEPRGWGDVL-TTLLCFVGSYTLGNDGIMCTTSYECQRK

38

+P+ W +V+ T+L C SY +GN G +CT + ECQ+

3

AQPQ-WAEVIITSLACAAASYFMGNPGHVCTLTVECQKS

40

35.7%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

5

GWGDVLTTLL-CFVGSYTLGNDGIMCTTSYECQ

36

GW V ++ C + S LGNDG +CT + ECQ

1

GWTGVAKSITSCSLLSIGLGNDGWVCTWTAECQ

33

35.7%

NZ_BCEY01000006.1and 1 other:

NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide

Lanthipeptides: GOZ53_RS01290_lanthipeptide

5

GWGDVLTTLL-CFVGSYTLGNDGIMCTTSYECQ

36

GW V +++ C + S+ LGNDG +CT + ECQ

1

GWTGVAKSIVSCSLISFALGNDGWICTWTAECQ

33

35.7%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09360_lanthipeptide

Lanthipeptides: AOX59_RS09360_lanthipeptide

1

VEPRGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

V+P+ LT C S +GNDG +CT + ECQ

2

VDPQT---ALTYSTCHWISPAMGNDGHLCTATVECQPN

36

35.7%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

6

WGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

WG +LTTL C S +G+ G +CT + ECQ

3

WGTLLTTLSCLAASIMIGDKGQVCTGTVECQNN

35

33.3%

NZ_BMFU01000012.1and 5 others:

NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide

Lanthipeptides: IEW26_RS25375_lanthipeptide

2

EPRGWGDVLTTLLCFVGSYTLGNDGIMCTTSYECQRK

38

+P ++T+L C SY +GN G +CT + ECQ+

4

QPEWVEVIITSLACAAASYFMGNPGHVCTLTVECQKS

40

MIBiG 4.0 matches for CN427_RS29360

26.2%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

16

FVGSYTLGNDGIMCTTSYECQ

36

F S LGN+G CT + ECQ

6

FSLSNALGNNGGWCTLTKECQ

26

19.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

22

LGNDGIMCTTSYECQ

36

LGN G CT + EC

10

LGNKGAYCTLTVECM

24

14.3%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

29

CTTSYECQ

36

CT S ECQ

28

CTLSKECQ

35

allorf_39377_39460

Leader:

MSFQKCIFNINNNYAFM

Core:

CNYDSNVMPF

Core with dehydrations:

CysNYDDhaNVMPF

antiSMASH-DB 4.0 matches for allorf_39377_39460

100.0%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: allorf_39377_39460_lanthipeptide

Lanthipeptides: allorf_39377_39460_lanthipeptide

1

CNYDSNVMPF

10

CNYDSNVMPF

1

CNYDSNVMPF

10

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.44 out of 28.14

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.71 out of 27.78

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.11 out of 30.25

Confidence: medium

Additional weak hits (1):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.25 out of 25.88

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

CN427_RS29300 - Class II

Cleavage pHMM score: -4.90

RODEO score: 0

Monoisotopic mass: 3147.6 Da

Molecular weight: 3149.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3167.6 Da N = 1; 3185.6 Da N = 2

CN427_RS29340 - Class II

Cleavage pHMM score: 0.50

RODEO score: 0

Monoisotopic mass: 3863.9 Da

Molecular weight: 3866.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3884.4 Da N = 1; 3902.5 Da N = 2; 3920.5 Da N = 3; 3938.5 Da N = 4; 3956.5 Da N = 5; 3974.5 Da N = 6

CN427_RS31525 - Class II

Cleavage pHMM score: 0.50

RODEO score: 0

Monoisotopic mass: 3876.0 Da

Molecular weight: 3878.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3896.4 Da N = 1; 3914.5 Da N = 2; 3932.5 Da N = 3; 3950.5 Da N = 4; 3968.5 Da N = 5; 3986.5 Da N = 6; 4004.6 Da N = 7

CN427_RS29360 - Class II

Cleavage pHMM score: -4.10

RODEO score: 0

Monoisotopic mass: 4386.1 Da

Molecular weight: 4389.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4407.0 Da N = 1; 4425.0 Da N = 2; 4443.0 Da N = 3; 4461.0 Da N = 4

CN427_RS29365 - Class II

Cleavage pHMM score: -4.10

RODEO score: 0

Monoisotopic mass: 4386.1 Da

Molecular weight: 4389.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4407.0 Da N = 1; 4425.0 Da N = 2; 4443.0 Da N = 3; 4461.0 Da N = 4

CN427_RS29370 - Class II

Cleavage pHMM score: -4.10

RODEO score: 0

Monoisotopic mass: 4386.1 Da

Molecular weight: 4389.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4407.0 Da N = 1; 4425.0 Da N = 2; 4443.0 Da N = 3; 4461.0 Da N = 4

allorf_39377_39460 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 1170.5 Da

Molecular weight: 1171.3 Da

Number of bridges: 1

CN427_RS29340 - Class II

Cleavage pHMM score: 0.50

RODEO score: 0

Monoisotopic mass: 3863.9 Da

Molecular weight: 3866.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3884.4 Da N = 1; 3902.5 Da N = 2; 3920.5 Da N = 3; 3938.5 Da N = 4; 3956.5 Da N = 5; 3974.5 Da N = 6

CN427_RS31525 - Class II

Cleavage pHMM score: 0.50

RODEO score: 0

Monoisotopic mass: 3876.0 Da

Molecular weight: 3878.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3896.4 Da N = 1; 3914.5 Da N = 2; 3932.5 Da N = 3; 3950.5 Da N = 4; 3968.5 Da N = 5; 3986.5 Da N = 6; 4004.6 Da N = 7

CN427_RS29360 - Class II

Cleavage pHMM score: -4.10

RODEO score: 0

Monoisotopic mass: 4386.1 Da

Molecular weight: 4389.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4407.0 Da N = 1; 4425.0 Da N = 2; 4443.0 Da N = 3; 4461.0 Da N = 4

CN427_RS29365 - Class II

Cleavage pHMM score: -4.10

RODEO score: 0

Monoisotopic mass: 4386.1 Da

Molecular weight: 4389.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4407.0 Da N = 1; 4425.0 Da N = 2; 4443.0 Da N = 3; 4461.0 Da N = 4

CN427_RS29370 - Class II

Cleavage pHMM score: -4.10

RODEO score: 0

Monoisotopic mass: 4386.1 Da

Molecular weight: 4389.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4407.0 Da N = 1; 4425.0 Da N = 2; 4443.0 Da N = 3; 4461.0 Da N = 4

allorf_39377_39460 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 1170.5 Da

Molecular weight: 1171.3 Da

Number of bridges: 1

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
PerR	Peroxide regulator

NZ_NTWJ01000004.1 - Region 1 - terpene-precursor

Download region SVG

Location: 451,105 - 471,995 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

CN427_RS05955: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

CN427_RS05920: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

CN427_RS05925: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

CN427_RS05925: PT_FPPS_like

Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.66 out of 26.06

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.32 out of 25.88

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33

Confidence: medium

Additional weak hits (2):

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.73 out of 30.98

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.40 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator

NZ_NTWJ01000051.1 - Region 1 - RiPP-like

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Location: 1 - 8,931 nt. (total: 8,931 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

CN427_RS29870: aminotransferase

smcogs: SMCOG1019: aminotransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000896.5	0.29	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000721.4	0.27	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000172.5	0.23	PKS	Basiliskamide A, Basiliskamide B	Brevibacillus laterosporus PE36
BGC0000381.5	0.23	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5	0.22	NRPS	surfactin	Bacillus velezensis FZB42
BGC0000455.6	0.22	NRPS, saccharide	vancomycin	Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2	0.22	other (other)	enduracididine	uncultured bacterium
BGC0001233.5	0.22	NRPS	feglymycin	Streptomyces sp. DSM 11171
BGC0001461.5	0.22	NRPS	Actinoidin B	Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5	0.21	NRPS	decaplanin	Amycolatopsis regifaucium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000896.5	0.29	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000721.4	0.27	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000172.5	0.23	PKS	Basiliskamide A, Basiliskamide B	Brevibacillus laterosporus PE36
BGC0000381.5	0.23	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5	0.22	NRPS	surfactin	Bacillus velezensis FZB42
BGC0000455.6	0.22	NRPS, saccharide	vancomycin	Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2	0.22	other (other)	enduracididine	uncultured bacterium
BGC0001233.5	0.22	NRPS	feglymycin	Streptomyces sp. DSM 11171
BGC0001461.5	0.22	NRPS	Actinoidin B	Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5	0.21	NRPS	decaplanin	Amycolatopsis regifaucium

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.24 out of 21.55

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.87 out of 32.93

Confidence: medium

Additional weak hits (4):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 19.98 out of 30.12

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.69 out of 30.12

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.35 out of 30.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_NTWJ01000051.1 - Region 2 - betalactone

Download region SVG

Location: 61,760 - 81,578 nt. (total: 19,819 nt) Show pHMM detection rules used

Region on contig edge.

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CN427_RS30210: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase carboxylase transferase

CN427_RS30165: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

CN427_RS30185: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

CN427_RS30205: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Lyases: hydratase

CN427_RS30190: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

CN427_RS30180: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CN427_RS30195: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.53	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000706.3	0.46	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000131.5	0.45	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001103.5	0.42	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001095.5	0.41	NRPS	fengycin	Bacillus velezensis FZB42
BGC0001464.3	0.40	other (other)	tetrabromopyrrole	Pseudoalteromonas sp. PS5
BGC0001463.4	0.40	other (other)	2,3,4,5-tetrabromopyrrole	Pseudoalteromonas piscicida
BGC0000259.3	0.39	PKS	prodigiosin	Serratia marcescens
BGC0002147.2	0.38	NRPS	bohemamine A, bohemamine B, bohemamine C	Streptomyces sp. CB02009

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.53	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000706.3	0.46	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000131.5	0.45	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001103.5	0.42	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001095.5	0.41	NRPS	fengycin	Bacillus velezensis FZB42
BGC0001464.3	0.40	other (other)	tetrabromopyrrole	Pseudoalteromonas sp. PS5
BGC0001463.4	0.40	other (other)	2,3,4,5-tetrabromopyrrole	Pseudoalteromonas piscicida
BGC0000259.3	0.39	PKS	prodigiosin	Serratia marcescens
BGC0002147.2	0.38	NRPS	bohemamine A, bohemamine B, bohemamine C	Streptomyces sp. CB02009

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.51 out of 27.55

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

Additional weak hits (1):

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.65 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
GnfM	Regulator of nitrogen-fixation genes
ToxT	Regulator of MSHA biosynthesis

NZ_NTWJ01000008.1 - Region 1 - NRP-metallophore,NRPS

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Location: 44,725 - 96,473 nt. (total: 51,749 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CN427_RS10725: Antibiotic biosynthesis monooxygenase

smcogs: SMCOG1258: Antibiotic biosynthesis monooxygenase

CN427_RS10805: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CN427_RS10870: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

CN427_RS10875: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

CN427_RS10880: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: PPTase

CN427_RS10770: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase protease

CN427_RS10745: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

CN427_RS10790: isochorismatase

smcogs: SMCOG1027: isochorismatase

Lyases: hydratase

CN427_RS10860: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Isomerases: isomerase

CN427_RS10800: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

CN427_RS10720: Pseudouridine synthase

smcogs: SMCOG1154: Pseudouridine synthase

CN427_RS10785: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

CN427_RS10795: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	1.05	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.89	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.86	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.86	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.85	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.77	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.74	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	0.80	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.75	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.74	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.99 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.83 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.13 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.57 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.62 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.41 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.40 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.53 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 28.19

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.21 out of 30.25

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.20 out of 32.93

Confidence: medium

Additional weak hits (6):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.54 out of 30.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.35 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.05 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.49 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.83 out of 32.74

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.85 out of 36.53

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 44724 - 96473:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

CN427_RS10785: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (464..864): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FAMTFDISALELQALVGGETNLYGPTETTIWSTF
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1524..1937): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQVFGGEINMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

CN427_RS10795: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SVSLYPMSSPGGALQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PMPAQGVVNK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
FuR variant 1	Ferric Uptake Regulator
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_NTWJ01000009.1 - Region 1 - NRPS

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Location: 27,109 - 74,707 nt. (total: 47,599 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxidoreductase

CN427_RS11820: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

CN427_RS11880: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

CN427_RS11890: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

CN427_RS11895: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: kinase

CN427_RS11885: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Lyases: decarboxylase

CN427_RS11815: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase

CN427_RS11825: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.67	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.62	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.67	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.62	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.23 out of 27.78

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.72 out of 27.04

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.01 out of 32.93

Confidence: medium

Additional weak hits (4):

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.15 out of 23.43

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.18 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.00 out of 32.74

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.31 out of 25.75

Confidence: weak

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 27108 - 74707:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu - Tyr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

CN427_RS11825: Leu - Tyr

Search NORINE for peptide: strict or relaxed

AMP-binding (477..877): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LSLAFDASIMEPLLFVGGELNAYGPTEATVCTTI
Nearest Stachelhaus code(s):: Leu DAMLVGAVCK (71% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1538..1944): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: LWRYFDSSVSESDLIMGGEVNEYGPTEATVSAMY
Nearest Stachelhaus code(s):: Lys DAEDIGTVSK (65% 8Å match)
Stachelhaus code match:: 70% (weak)