LOCUS       NZ_NTWJ01000051        19819 bp    DNA     linear   CON 01-APR-2024
DEFINITION  Bacillus thuringiensis strain AFS009835
            AFS009835_104_C9_Contig51_140523, whole genome shotgun sequence.
ACCESSION   NZ_NTWJ01000051
VERSION     NZ_NTWJ01000051.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus thuringiensis
  ORGANISM  Bacillus thuringiensis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 81578)
  AUTHORS   Bleich,R.M., Kirk,G.J., Santa Maria,K.C., Allen,S.E., Farag,S.,
            Shank,E.A. and Bowers,A.
  CONSRTM   Agbiome Team Llc
  TITLE     Large-scale bioinformatics analysis of Bacillus genomes uncovers
            conserved roles of natural products in bacterial physiology
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 81578)
  AUTHORS   Bleich,R.M., Kirk,G.J., Santa Maria,K.C., Allen,S.E., Farag,S.,
            Shank,E.A. and Bowers,A.
  CONSRTM   Agbiome Team Llc
  TITLE     Direct Submission
  JOURNAL   Submitted (07-SEP-2017) Chemical Biology and Medicinal Chemistry,
            UNC Chapel Hill, 125 Mason Farm Rd., Chapel Hill, NC 17599, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Assembly Cell v. 4.2.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 61.85x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002562205.1-RS_2024_04_01
            Annotation Date                   :: 04/01/2024 01:49:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,978
            CDSs (total)                      :: 5,906
            Genes (coding)                    :: 5,721
            CDSs (with protein)               :: 5,721
            Genes (RNA)                       :: 72
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 185
            CDSs (without protein)            :: 185
            Pseudo Genes (ambiguous residues) :: 0 of 185
            Pseudo Genes (frameshifted)       :: 82 of 185
            Pseudo Genes (incomplete)         :: 109 of 185
            Pseudo Genes (internal stop)      :: 57 of 185
            Pseudo Genes (multiple problems)  :: 52 of 185
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:13:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 61759
            Orig. end                         :: 81578
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NTWJ01000051.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..19819
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="betalactone"
                     /region_number="2"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..19819
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..19819
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[10000:15239](-)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15239)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            complement(361..1098)
                     /gene="mtnN"
                     /locus_tag="CN427_RS30115"
                     /old_locus_tag="CN427_30115"
     CDS             complement(361..1098)
                     /EC_number="3.2.2.16"
                     /EC_number="3.2.2.9"
                     /GO_function="GO:0008782 - adenosylhomocysteine
                     nucleosidase activity [Evidence IEA]"
                     /GO_function="GO:0008930 - methylthioadenosine nucleosidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019509 - L-methionine salvage from
                     methylthioadenosine [Evidence IEA]"
                     /codon_start=1
                     /gene="mtnN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129475.1"
                     /locus_tag="CN427_RS30115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30115"
                     /product="5'-methylthioadenosine/S-adenosylhomocysteine
                     nucleosidase"
                     /protein_id="WP_000151939.1"
                     /transl_table=11
                     /translation="MTIGEVKRVMKRIAIVSAWEPELTYLHQHYPSERVEKRAAWEFHF
                     HTINELEIISVVTGVGKVSCASCVQLLISEFQPDELFMTGICGSLSNKVKNGHIVVALN
                     AIQHDVTAAGSGEDVFNLYNGRTAPIETTKSLVRRIKKIRSYDPIHFGTFLSGDQRIRS
                     SEMRYLLHTVYGALAVDQEVAAFAYVCQINKKPFLCLKAASDQANDKTKEEQKIFKMLA
                     CERACEHLIAFLRVYEINVVNNR"
     gene            complement(1095..1769)
                     /locus_tag="CN427_RS30125"
                     /old_locus_tag="CN427_30125"
     CDS             complement(1095..1769)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002156408.1"
                     /locus_tag="CN427_RS30125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30125"
                     /product="DUF3885 domain-containing protein"
                     /protein_id="WP_071714863.1"
                     /transl_table=11
                     /translation="MQLKEYMNQTFPGVTLGPYLYSQWGNHLYFDFGKDKYQIVEGTDD
                     LNMEYFSQLYTYNKFLFEDIFSKEDVVFVVTNVYRFKKENIKTPQKINVYNKYIKKRDL
                     RFHIRQETLPFLFEDEEADLYCTYHFSLKCLAEDIKYELLIQAANHEDFSALYPRFGRK
                     KEISYPDVFLINATKDIVMFMCDDRGCKVIAKNKEIIRDLYKKYKEWIPDYERESIDNL
                     FK"
     gene            complement(1783..2390)
                     /gene="yqeK"
                     /locus_tag="CN427_RS30130"
                     /old_locus_tag="CN427_30130"
                     /pseudo=""
     CDS             complement(1783..2390)
                     /codon_start=1
                     /gene="yqeK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000965880.1"
                     /locus_tag="CN427_RS30130"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30130"
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLYSDIYSFTPTGKIENDIKAFLLKYNKEFTYKHSIRVANEAKKI
                     AEKFHVDKEKAAIAGYLHDISGIFPNEERIAVAEEFGVEIVEAEKSFL"
     gene            2583..3278
                     /locus_tag="CN427_RS30135"
                     /old_locus_tag="CN427_30135"
     CDS             2583..3278
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanR"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038809.1"
                     /locus_tag="CN427_RS30135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30135"
                     /product="response regulator transcription factor"
                     /protein_id="WP_001038809.1"
                     /transl_table=11
                     /translation="MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQKVSTY
                     EVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVMNGEKLIHTV
                     WGVGYKIEK"
     gene            3268..4425
                     /locus_tag="CN427_RS30140"
                     /old_locus_tag="CN427_30140"
     CDS             3268..4425
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129473.1"
                     /locus_tag="CN427_RS30140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30140"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_001243312.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIYRLVTSVIES
                     SLTLTELGKEFIRIFGYEKYKGIKESLWMMIVSYLFLFSIFSSYLYIFYRHEKKLYYET
                     CIKKMIEEIRYIANGNFNHKVSIVNHNYLEELAIGVNEIVEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRYYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSVPIDIVELLGQLTVQFRIQVQEANIECRPSFPSQKLMVLADGDKLVRV
                     FENLIINAIAYGSEGRYIDLTAYESNNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDEKTTFTVKLLPYKC"
     gene            4601..5617
                     /locus_tag="CN427_RS30145"
                     /old_locus_tag="CN427_30145"
     CDS             4601..5617
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="CN427_RS30145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30145"
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_098353355.1"
                     /transl_table=11
                     /translation="MQFLKKFAILLLSFFITALIVLYFYLYVNGPIIQAKSAILINANS
                     GEIVYKKNEETPVQSATLSKLMTEYIVLEQLNDRKIQLDDFVQISNEVFRVETSPIQVT
                     SNDKTTVRDLLHALLLAGNNRSALALAEHIAGNEDNFTILMNKKAKELQLLQPSPFLNS
                     TGINHDTNKQSTTTAIDAAKLAARLVKDFPDVLNITKLTSYQFTFKDSQVFNTNKMIYS
                     LNENIKLQGVDGLQTSFSTNGNYSFVSTAKLGDTRLISVILDADEENISFIETKKLLQY
                     GFDPSSYSALQAFIDTLTSWTILLQFKNLIIQTIMIFLIITTLMFLHIRQKKSEDFN"
     gene            complement(5679..>5789)
                     /locus_tag="CN427_RS30150"
                     /old_locus_tag="CN427_30150"
                     /pseudo=""
     CDS             complement(5679..>5789)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288863.1"
                     /locus_tag="CN427_RS30150"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30150"
                     /product="DinB family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="VLRHVIVHEIHHIGQLSIWARELNLQPVSANLIGRG"
     misc_feature    5793..5802
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            5955..6092
                     /locus_tag="CN427_RS30155"
                     /old_locus_tag="CN427_30155"
     CDS             5955..6092
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376553.1"
                     /locus_tag="CN427_RS30155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30155"
                     /product="DUF3956 domain-containing protein"
                     /protein_id="WP_000376554.1"
                     /transl_table=11
                     /translation="MDSCVVFVNGQPFLVLSVAGIEIARLEISLQVALALRVLGIPICD
                     "
     misc_feature    complement(6183..6199)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.65"
                     /tool="antismash"
     misc_feature    complement(6639..6655)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.51"
                     /tool="antismash"
     gene            6806..7414
                     /locus_tag="CN427_RS30160"
                     /old_locus_tag="CN427_30160"
     CDS             6806..7414
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000807974.1"
                     /locus_tag="CN427_RS30160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30160"
                     /product="hypothetical protein"
                     /protein_id="WP_000136053.1"
                     /transl_table=11
                     /translation="MTEIKVGLTQFLDFTLKGSTAKTTFIKNLKSQPEYQPAFDYWKQL
                     RETVIKFHQNKLSFEYFETLVQTVDQKKKQNYIDVIKQYKKFIKNKDISWFDPGKSHWK
                     SDDLIVRSSPELGLFINNEPHLIKLFFKGKKERIDKYNINSTLTLLNESTFSNERNDVN
                     YTVLNIQKNRMYTNNSINNNHLVALKSEANQFCYIWNNL"
     gene            complement(7685..8218)
                     /locus_tag="CN427_RS30165"
                     /old_locus_tag="CN427_30165"
     CDS             complement(7685..8218)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002007691.1"
                     /locus_tag="CN427_RS30165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30165"
                     /product="GNAT family protein"
                     /protein_id="WP_000990089.1"
                     /transl_table=11
                     /translation="MMYERSMEVIKLKTFKKSDFKQLINWINSEEFLIQWSGNAFTFPL
                     DEQQLEKYIESANTLAFKVVDEETSDVIGHISLGQIDNINKSARIGKVLVGNTKMRGRS
                     IGKHMMKAVLHIAFDELKLHRVTLGVYDFNISAISCYEKIGFVKEGLLRESKRVGETYW
                     NLWEMSMLEYEWKK"
     misc_feature    complement(8294..8309)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     gene            complement(8324..8680)
                     /locus_tag="CN427_RS30170"
                     /old_locus_tag="CN427_30170"
     CDS             complement(8324..8680)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000535569.1"
                     /locus_tag="CN427_RS30170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30170"
                     /product="hypothetical protein"
                     /protein_id="WP_000535577.1"
                     /transl_table=11
                     /translation="MGSRFNNCKKKCTCKQDDCWEVFEECKKEQHEKCDNSCVQGIRDE
                     LKKLINRTVQINTEGRTYVGTVSSVSCDVVRLAAIPGSVGVIISICKIEAIFPPVTTVT
                     ADFDFNGIDVANKA"
     gene            9243..9680
                     /locus_tag="CN427_RS30175"
                     /old_locus_tag="CN427_30175"
     CDS             9243..9680
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CN427_RS30175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CN427_30175"
                     /product="hypothetical protein"
                     /protein_id="WP_172794262.1"
                     /transl_table=11
                     /translation="MKGGRNKCPGKMIAGVLRKSIVVMIGGNLKKSIIVMMIGVLRKSI
                     VMMIGGNLKKSVIVMTIGVLRKNIVMMIGGNLKKSVLVMMIGVLNEISVVVNVSLFVAI
                     VKEKIGNIFNVNVKKKICLLESIRLFRKVDPSPTSLLSLNF"
     gene            complement(10001..11941)
                     /locus_tag="CN427_RS30180"
                     /old_locus_tag="CN427_30180"
     CDS             complement(10001..11941)
                     /NRPS_PKS="Domain: AMP-binding (99-521). E-value: 3.9e-82.
                     Score: 267.9. Matches aSDomain:
                     nrpspksdomains_CN427_RS30180_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="CN427_RS30180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30180"
                     /product="AMP-binding protein"
                     /protein_id="WP_000806505.1"
                     /sec_met_domain="AMP-binding (E-value: 2e-89, bitscore:
                     292.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLYSWMKSLGYEDYETFYNKSIEETAWLW
                     GEAEKAVGYQWMKPYTEVLDLENGTPFAQWYNGGTCNVVESALSRWLADEETRIQPALQ
                     YEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDIIEAAAIGVPDEVKGEVCHCFVVLRDHVTFTGELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     CDS_motif       complement(10346..10408)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CN427_RS30180_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="CN427_RS30180"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     aSDomain        complement(10379..11644)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CN427_RS30180_AMP-binding.1"
                     /evalue="3.90E-82"
                     /label="CN427_RS30180_AMP-binding.1"
                     /locus_tag="CN427_RS30180"
                     /protein_end="521"
                     /protein_start="99"
                     /score="267.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QPALQYEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTI
                     YMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIV
                     SLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPL
                     MLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFG
                     SLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLK
                     SLEVFASTGEPWNPDPWMWLFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFN
                     ASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVH
                     GDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       complement(11099..11155)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CN427_RS30180_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="CN427_RS30180"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     gene            complement(11991..13532)
                     /locus_tag="CN427_RS30185"
                     /old_locus_tag="CN427_30185"
     CDS             complement(11991..13532)
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094296.1"
                     /locus_tag="CN427_RS30185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30185"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_000886744.1"
                     /transl_table=11
                     /translation="MLDQKQQSNSFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGSRTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVCLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNM
                     KDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYHLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            complement(13535..14323)
                     /locus_tag="CN427_RS30190"
                     /old_locus_tag="CN427_30190"
     CDS             complement(13535..14323)
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 1.6e-75. Score:
                     245.5. Matches aSDomain:
                     nrpspksdomains_CN427_RS30190_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="CN427_RS30190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30190"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_000939814.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLYRERQANSLSLALLDELQTILTQI
                     SEDSNVRVVILTGAGEKAFCAGADLKERADMNEEQVRHAVSMIRTTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRIEGLQAFKEKRKPMYKGE"
     aSDomain        complement(13562..14281)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CN427_RS30190_ECH.1"
                     /evalue="1.60E-75"
                     /label="CN427_RS30190_ECH.1"
                     /locus_tag="CN427_RS30190"
                     /protein_end="254"
                     /protein_start="14"
                     /score="245.5"
                     /tool="antismash"
                     /translation="HVVKISLYRERQANSLSLALLDELQTILTQISEDSNVRVVILTGA
                     GEKAFCAGADLKERADMNEEQVRHAVSMIRTTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRIEGLQAFKEK"
     gene            complement(14328..15239)
                     /gene="mvaB"
                     /locus_tag="CN427_RS30195"
                     /old_locus_tag="CN427_30195"
     CDS             complement(14328..15239)
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="CN427_RS30195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30195"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_000775435.1"
                     /sec_met_domain="HMGL-like (E-value: 3.2e-49, bitscore:
                     160.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISVTAVDELC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGIKTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            complement(15261..15476)
                     /locus_tag="CN427_RS30200"
                     /old_locus_tag="CN427_30200"
     CDS             complement(15261..15476)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="CN427_RS30200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30200"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001987345.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIISE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            complement(15503..16840)
                     /locus_tag="CN427_RS30205"
                     /old_locus_tag="CN427_30205"
     CDS             complement(15503..16840)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="CN427_RS30205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30205"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_098399377.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 7.1e-12,
                     bitscore: 37.5, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 5.4e-08, bitscore:
                     25.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 8.7e-08, bitscore: 24.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 4.8e-11, bitscore:
                     34.8, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADTHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIASGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPSNVRIDHFLENHVTITPFYDPMIAKVIAHGETREEAISK
                     LHDALEELKVEGIKTNTPMLLQVLEDEVFKEGIYTTGFVTKQLVKK"
     gene            complement(16856..18001)
                     /locus_tag="CN427_RS30210"
                     /old_locus_tag="CN427_30210"
     CDS             complement(16856..18001)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="CN427_RS30210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30210"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_000397279.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.5e-41, bitscore:
                     133.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 7.9e-28, bitscore:
                     88.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1e-58, bitscore:
                     190.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAVLDGDEYVISGEKCWITNAEYA
                     NTIIVTAVNGIEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANQAVQIHG
                     GYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            complement(18218..19186)
                     /locus_tag="CN427_RS30215"
                     /old_locus_tag="CN427_30215"
     CDS             complement(18218..19186)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="CN427_RS30215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30215"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_001248644.1"
                     /transl_table=11
                     /translation="MRQFAKPTIVVSKCLEFDACRYNGEMIPDVTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEENGENRLVQPSTREDVTEKMEQFSNDFLQTISDVDGFILKN
                     RSPSCGTRDVKIYSGFEKAPAKGKGAGLFGGAVVKNFSYLPIEEEGRLSNFIIREHFFT
                     RLFTIAYYKMIKHNKNMKELVSFQSDNKYLFMAYNQVKQKELGRIIANQKNEKIEVVFE
                     NYEKTLYELFMRAPRYTSNVNVCEHIFGYFKTKLKKQEKDHFIELLQKYAEKKIPLSSL
                     LTILKSWAIRFDEKYLLRQTYFEPYPEALVEISDSGKGRDY"
     gene            19420..19719
                     /locus_tag="CN427_RS30220"
                     /old_locus_tag="CN427_30220"
     CDS             19420..19719
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728146.1"
                     /locus_tag="CN427_RS30220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_30220"
                     /product="WGxxGxxG family protein"
                     /protein_id="WP_000728159.1"
                     /transl_table=11
                     /translation="MKKKLSSILSVLTLSIMFLGTSTQAEYDGNNMNRVNNTDISTRVN
                     DNNLDRVNNDVRTRNVNTTNDLNDNRDKNNNWAWLGLLGLAGLLGLRRRDKETR"
ORIGIN
        1 cataatcctt tataccacct aatattacgc caactgattt gtcaccgtct aaagcaagaa
       61 aagaatgttc tagcaaatta ccttctggtc ccaaaaaacg gtgtataaaa tcaccttttg
      121 aaacttccat cttaataata taatcggaaa atccatcttt aaaagcttca tatactaaat
      181 caatatttac ttcactacat cttttatatt gaatcatata aaattgccct ccaattgctt
      241 gtattaaccg caacatgtac ccatataata tattccatct attataaatt tcagctctta
      301 atttgaaatg aacggacatt tccctacata taacccacta ttaatttgtt ttataacaaa
      361 ctatctatta tttactacat taatctcata aacacgcaaa aaagcaatta aatgctcaca
      421 tgctctttcg catgctagca ttttaaagat tttttgttct tctttcgttt tatcatttgc
      481 ttgatctgaa gcagctttta aacatagaaa tggtttttta tttatttggc atacataggc
      541 gaaagctgct acttcttgat caactgccaa tgctccatat acggtatgga gtaaatatct
      601 catttctgaa ctgcgaatac gttgatctcc ggataaaaat gtaccgaaat gtattggatc
      661 atatgatcgt atttttttta ttcttcttac aagtgatttt gttgtttcaa taggtgctgt
      721 tctaccgtta tataaattaa aaacatcttc ccctgagcca gctgcagtaa catcgtgttg
      781 tattgcgttt agtgccacta caatatgacc gtttttcacc ttgtttgata aacttccgca
      841 tattcctgtc ataaacaact catctggctg aaactcacta attaacaatt gtacacaact
      901 agcgcagctt actttaccaa caccagtaac aactgatata atttccagct cattaatagt
      961 atgaaaatga aattcccaag ctgctctttt ttcaacacgt tcactcggat aatgttgatg
     1021 caaatacgtc agttctggtt cccatgcaga tactattgca atacgtttca ttacacgctt
     1081 cacttcccct attgtcattt aaataagtta tctatacttt ctcgttcata atctggaatc
     1141 cattctttgt atttcttata taaatctcgt attatttctt tattcttcgc aattacttta
     1201 catcctctat catcacacat aaacatgaca atatctttcg ttgcatttat gagaaataca
     1261 tctggataag aaatttcttt ttttcgtcca aatcgaggat acagagcaga gaaatcctcg
     1321 tgattagcag cttgtataag caattcatac ttaatatctt ccgcaagaca ttttaaagaa
     1381 aaatgatatg tacaatataa atctgcttct tcatcttcaa atagaaacgg taacgtttct
     1441 tgtcttatat gaaatcttaa atctcttttc ttaatatatt tattgtatac atttattttc
     1501 tgtggagttt ttatgttttc ctttttaaat ctataaacat ttgtcactac aaacactaca
     1561 tcttcttttg aaaatatgtc ttcaaataag aatttattat atgtatatag ttgagaaaag
     1621 tattccatat ttaaatcgtc ggttccttct acaatttgat atttatcttt tccgaaatca
     1681 aaatataaat gatttcccca ctgagaatat aagtagggtc ctaatgtaac tcctggaaat
     1741 gtttgattca tatattcttt taattgcatt tccttgtcct ttctactgta aaattccttt
     1801 taaatcccag tatgcttctt ctagccacgg atgtataact ttcaatgtat ctttcctttc
     1861 ccacaaatat gaaatatata caaaagctgc tttttccaaa gatttttcca atcctttttt
     1921 tatttctatt aaatatggtg gtgtcccgtt ttgatcccat tctattttat ctgcaacaaa
     1981 taatactaaa tccatcttcg ttgcatgttt acgcaacgtt gtatggcaac aaattgcatt
     2041 taaaatttct tcattttcta ctttaaatat ttcttttgcg attactctcg ataatttttg
     2101 atgaataatc ataggaaact tttttctgct tccactatct ctaccccaaa ctcttcagca
     2161 actgcaatcc tctcctcgtt cggaaaaatg ccactaatat catgtaaata tcctgcaatt
     2221 gctgcttttt ctttatctac gtgaaacttt tctgcaatct tttttgcctc atttgccaca
     2281 cgaattgaat gtttatatgt aaactcttta ttatatttta gtagaaaggc tttaatatca
     2341 ttttctattt ttccagttgg agtaaatgaa tatatatcac tatataacat agaaaatccc
     2401 ccttataact aacttacatt ataatgtaga atctaaatat cctttttatt ttatattcga
     2461 tattaatctt tttactcctt tttaatacgt tacatgaaat tttatacaaa atcatcgcta
     2521 caagtacata aatgtttgat attatagtaa tgttgatgat ttgtaaggaa aggaactaca
     2581 caatgaataa aaacatatta attattgatg atgataaaga aattgttgaa ttacttgctg
     2641 tttatttgcg aaatgaaggc tataacattt ataaagctta tgatggcgat gaagcattgc
     2701 aaaaggtttc tacatatgaa gttgacctta tgattttgga tattatgatg ccaaaacgaa
     2761 acggattaga agtttgtcag gaagtacgtg aaaataatac tgtaccaatt ctaatgctta
     2821 gtgcaaaagc agaagatatg gataaaatat taggccttat gacaggtgcc gatgattata
     2881 tgatcaaacc attcaatcca ttagaattag tagctagagt gaaagcttta ttacgaagat
     2941 cctctttcca aaatgctact tcgcaaaaga atgaagatgg tattattcgt attcgctctg
     3001 ttgaaataca caaacataat catacagtta aagtaaatgg agagtatatt aaactaacct
     3061 ctattgaatt cgatatttta tatttacttg cgagtaatac aggaagagta tttagttcag
     3121 aagaaatttt cgaacgcgtt tggaatgaag atggttatgg ttcaaataag acggtaatgg
     3181 tccatattag caacttacga gataaacttg aaacagtaat gaatggagaa aaattgattc
     3241 atactgtttg gggagttggc tataaaattg agaaatgaag catttgatat attaaaagat
     3301 attcctaaat ggaaacttat tttttggctt ttattagcta tcacactcac tcctattact
     3361 gaactaatta tttatcgcct cgttacgagt gtaattgaga gttcacttac tctaactgaa
     3421 ctcggtaaag aattcattcg aatttttggt tatgaaaagt ataaagggat taaagagtct
     3481 ttatggatga tgattgtatc ttatttgttt ttattttcta ttttttcatc ctatctttac
     3541 attttttatc gtcacgagaa aaaactttat tatgaaactt gtataaaaaa aatgatagaa
     3601 gaaattcgtt atattgcaaa tggaaacttc aatcataaag tttctattgt aaatcataat
     3661 tatctagaag aattagcaat cggggtcaat gaaattgttg aacaattaaa agtctccatt
     3721 gatgaagaaa gacaagcgga acaagcaaaa agtgaactta ttacaaatgt atcacatgac
     3781 ttacgcaccc ctcttacttc tatagttgga tacgtaaatt taatccatca tgataattat
     3841 agagatgaag tggaattgcg atactatatt caagtcattt acgataaagt aactcgtctt
     3901 aatgcattaa tgaatgactt gttcgaatat acacgtgttc aaaataaaga attaagcttg
     3961 tattctgttc ctattgatat tgtagagtta cttggacaat taactgttca attccgcata
     4021 caggttcaag aagctaatat agaatgtcgg ccttctttcc cgtctcaaaa gcttatggta
     4081 ttagctgatg gtgacaaatt agtgcgtgtg tttgaaaatc ttattataaa cgctatcgct
     4141 tatggaagcg aaggtcgcta tattgacctt actgcttatg aaagcaataa tatgattaca
     4201 attgatataa caaattacgg acaacctatt cctagtacgg atttacctca tatttttgaa
     4261 cgtttttacc gcgttgagaa atctcgctct acaaacactg gtggatctgg acttggatta
     4321 gcaattgcaa aaagtatagt cgagttgcat aaaggaacaa ttgaagtata tagtgatgac
     4381 gaaaaaacaa cattcactgt aaaactactt ccatacaaat gttaatatta caaataaaaa
     4441 gttcaatttc ttatcatata agaaattgaa ctttttctat tatttcccta aatttaataa
     4501 tcctttataa ttctttagaa attctttacc ttttctttct tcctaattaa gcattccttt
     4561 ttacaatact attattgatg tcataatagg aggatcactt atgcaattct taaaaaaatt
     4621 cgctatttta ttattatctt ttttcattac tgcacttatc gttttatatt tttatcttta
     4681 tgtaaatggt ccgattattc aagctaaatc agctatttta ataaatgcta attcaggtga
     4741 aattgtttat aaaaaaaatg aagaaacccc agtacaatca gctactttat ctaaattaat
     4801 gacggaatat atcgtattgg aacaactaaa tgatagaaaa atacagttag atgacttcgt
     4861 acaaataagt aacgaagttt tccgagtaga aacaagccct atacaagtaa catcgaatga
     4921 taaaacaacg gttcgtgatt tacttcatgc attgctactg gcagggaata atcgttctgc
     4981 actcgctcta gcagaacaca ttgctggaaa tgaagataac tttacaatat taatgaataa
     5041 aaaagcaaaa gaactacagt tattacaacc atctccattt ctaaactcta ctggaattaa
     5101 tcatgataca aataaacaat caactacaac agcaatagac gcagctaaac tagctgcacg
     5161 attagtaaaa gattttccag atgtattgaa tattacgaaa ctaacctctt accaatttac
     5221 cttcaaagat tcccaggttt tcaatacgaa taaaatgata tattccctta atgaaaacat
     5281 taaacttcaa ggtgttgatg gcttacaaac tagtttttca actaacggta attatagttt
     5341 tgtcagtaca gcaaaactag gagatactag actaatttca gtaatattag atgcagatga
     5401 agaaaacatc tcatttattg aaacaaaaaa gttgctacag tatggttttg atccttcctc
     5461 gtactctgca ctccaagctt ttatagacac ccttacatct tggacaatat tgcttcagtt
     5521 taaaaactta attatacaaa ctataatgat tttcttaatc attaccacct taatgttttt
     5581 acatatacgt cagaaaaaat ccgaggattt caattaagaa atcttcttat atataaaaac
     5641 cgacttgcgc ttgagatgca agtcggtttt taattctatc atcctcgtcc aatcaaattt
     5701 gctgaaactg gttgcaagtt taactccctc gcccatatag atagctgacc aatatgatgg
     5761 atttcatgta cgattacatg tcttaaaacc tatgtttttt gaggcataca tccatctccc
     5821 tttcctttcg ttgtattcgt ttgtttagtt taaatgggtt aatctattaa ttctattaaa
     5881 tccaacaatt taactattac actttaaagt tctattcata tactatagta gattactaga
     5941 aaggaggttt aactatggat agttgcgttg tatttgtaaa cggacaacct tttttagttc
     6001 tttcagtagc tggtattgaa attgctagat tagagatttc ccttcaagta gcattagctc
     6061 taagagtgct tgggatacca atctgtgatt aattaccaaa ttaataagaa aagagggcat
     6121 tagccctctt tttttatttt cttctcacct tttcttaaca acaaataaaa tttaaatttt
     6181 atttgttata ttgtaatgaa aatccgaaaa atcaacccat tttattcaat aaaaaagagc
     6241 accacccata cctcattatc cgtttctata atattcaagt ttgattaata ataaaattaa
     6301 agtatatgaa cgttacatga aacacttgtt aagatagctc tccttcacac tatttatttc
     6361 gctgacgcta tattatcaaa gcacacaatg attaactttt tatacggctt attttaagtg
     6421 tgcttgccaa tacttttact tgtatgttct atacactcat tctctacggt atactgatac
     6481 caacttatat tttttgatga gggcccattt ccctatatcc ctctttattc ccatgtactt
     6541 tttttctcaa atccaagcta aataatctat attgttatct tttaaaatca gctcactatc
     6601 tgattatatt aataacctat cacctggtaa aatcctatta cctaatttat cttcaattga
     6661 atggtccatc atttatactt acggattggc tttcccgtat ctattgtgca tggatattgg
     6721 attttctagc atctagctca tttctttaaa aatgtcggat ttttcgtcta ttattaaatg
     6781 aataatgttt ggaaggggat ataatatgac agaaattaaa gtagggctta cacaattttt
     6841 agacttcaca ctgaaaggta gtacagctaa aacaaccttt ataaaaaatc taaaatccca
     6901 acctgaatat caaccagctt ttgattactg gaaacaatta cgagaaactg ttattaaatt
     6961 tcatcaaaac aaactatctt ttgaatattt cgaaacatta gtacaaacgg ttgatcagaa
     7021 aaaaaaacaa aactacattg atgtcataaa gcaatacaaa aaattcatta aaaataaaga
     7081 catctcttgg tttgatccag gtaaatcaca ttggaaatca gatgatttaa tcgtccgttc
     7141 atcacctgaa cttggcttat tcattaataa tgagccacat cttatcaaac tgtttttcaa
     7201 aggaaaaaaa gagcgaattg ataagtacaa cattaactcg acacttacac tattaaatga
     7261 atcaacattt tcaaatgaac gaaacgatgt gaattatacg gtacttaaca tccaaaagaa
     7321 cagaatgtat acgaataact ctattaataa taatcattta gtagcgctta aatcagaagc
     7381 taaccagttt tgctatatat ggaataatct ataaaggtta ctattcatcc cttttaatac
     7441 cttgttgatg catactttag ttacaatttt tacagattca ttcagtttcg tttaattagg
     7501 gctcaccctc ttattcctca gaaacaatgc aggtgggcct ttttcaaaaa tggtttcttt
     7561 gtcagtttta acatactagc tatcccccga aacagctgca attgaaatta tttttgtttt
     7621 attattcact atacccacca agcccctttt gttaacataa tataattata aattactatc
     7681 gttgctactt cttccattca tattctaaca tactcatttc ccataaattc caatacgttt
     7741 ctcctactct ttttgactct cttaataagc cttcttttac aaaccctatt ttttcgtaac
     7801 atgaaatggc cgatatatta aaatcataca caccaagagt tactctatgt agttttaatt
     7861 cgtcaaaagc aatatgaagt actgctttca tcatatgttt tcctatagaa cgtcccctca
     7921 tcttcgtatt accaactaat acttttccaa ttctagcgga cttattaata ttatctattt
     7981 gcccaagcga aatatgacca ataacgtctg aagtctcttc atctaccact ttgaaagcga
     8041 gtgtatttgc actttctata tacttctcta attgctgttc gtctaaaggg aatgtgaatg
     8101 catttcctga ccattgtatt agaaattctt cggaattaat ccaatttatt aattgtttaa
     8161 aatcagattt tttaaaggtt tttagtttaa tcacttccat gctcctttcg tacatcatac
     8221 tttataacct caaacttatt tctatataaa gaatatattc tccttttata tgaaattaaa
     8281 ataaagccat tcatgtgaat ggctttacaa aaaagcagca taattatgcc ttgtttgcta
     8341 catcaatacc attaaaatca aagtcagcag taaccgttgt aacaggtggg aaaattgctt
     8401 caattttaca aatggaaata attactccaa ccgatccagg aatagccgca agcctaacta
     8461 catcacaact tacagacgaa acagtaccta cataagtacg tccctctgta ttaatttgaa
     8521 ctgttcgatt aattaatttc ttaagttcat ctctaattcc ttgtacacaa gaattatcac
     8581 atttctcatg ctgttctttt ttacactctt cgaatacttc ccaacaatca tcttgtttac
     8641 atgtacactt ctttttacaa ttattaaatc gagaacccaa tacctcaccc cctaatcctt
     8701 tctattagta aagtatgtcc actagcttaa aagggtacga ggcaaacaca taaaaagaaa
     8761 aaaacaaaca attgtaccaa accttctttt cattattcat tataaaaaca gacttctcct
     8821 aattaaaatc ttgtttaatg agcggccgtg aatttagtcc tactccattt aatgtttaga
     8881 caccactttc taaaacaaat ctttttcttt taataagacg ccccttaaaa acacactaga
     8941 ttttcccatt aactcacata tacatagact ttatttgtgg atttcccatt tttcattgtg
     9001 aaatatacat ttaaaaagcg tactcgaaaa taagatatta tttgtaatca gaacattttc
     9061 ttcaataaat gtttattgaa aaataccata actagtagta gttctctcca ctttctctta
     9121 aaaattagca tagtttgtat gaattctata tcgagtagaa gacactctat catataaaga
     9181 taaaatagta ggttaataaa caagccattt ttttattaaa acatagaata atatgaacac
     9241 tattgaaagg aggtagaaat aaatgtcctg gaaaaatgat tgctggagtt ctcagaaaaa
     9301 gcattgttgt gatgattggt ggaaatctaa agaaaagcat cattgtgatg atgattggag
     9361 ttctcagaaa aagcattgta atgatgattg gtggaaatct aaagaaaagt gtcattgtga
     9421 tgacgattgg agttctcagg aaaaacattg taatgatgat tggtggaaat ctaaagaaaa
     9481 gtgtcctcgt gatgatgatt ggagttctaa acgaaataag tgtcgttgta aatgtttctt
     9541 tatttgttgc cattgtaaaa gaaaaaattg gtaatatttt taatgtcaac gtaaagaaaa
     9601 aaatatgtct tttggaatca atcaggcttt tccggaaagt tgatccctca cctacttcct
     9661 tgctttcgct gaatttttag gtgggggcat tactgcccgg caaatagcga gataaatact
     9721 aggatgtaat atataaaaag ctgactgagt atagtcagct ttttatatat taatacgtaa
     9781 aggtttaaac cggcatataa gcagtcgcgc tttgtcatca ccttgttgtt gtaaattagt
     9841 atttctccat tgaatagaca ttccataata tcgtattttg attaaaacaa aaaacatact
     9901 taacaccaat agtagaattt ttcttcttca tcaacttcac ttcttctctt tttataaaca
     9961 taaaaaagga tctctattta tatagagatc ctttctaatt ttataattta ctagactgta
    10021 acccctgaat aaacggaact acttcaggat ttacaagtga agacaaatca cctaattctt
    10081 ttcctaagta agctgcttta ataacacggc gcattacttt agaattacgt gttttcggta
    10141 aatcttctac aacgtggatg tctttaggac acaacgcttt tccaatatga gagtttacta
    10201 aactcattaa ttctttcttt aattcccctg tgaatgttac atggtctctt aacactacaa
    10261 aacaatgaca aacttcacct tttacttcgt caggtacacc aattgcagca gcttcgatta
    10321 tatcgttatg tttcacaaga atagattcat attcagcagg tccaatacgt ttacctgcaa
    10381 tatttaacgt atcgtctgaa cgccctgtga tgatatattg ttcaccatcg taaatgaccc
    10441 agtcaccgtg gacccattta ttttcaaaac gcgaccaata tgtgtttacg taacgttcat
    10501 catcttccca gaagcttttc gtcataccta cccaaggttt ctctaagcat aattctccga
    10561 cttcatctcg aattggttta ccttgatcat ccagtacgac agctgccatt cctggtaaag
    10621 atgcgttaaa actaatcggt gcgattggct taataagaac attgccgaaa atcccaccag
    10681 agatttcagt tccacctgag tagttacaga ttggaacatt tccttttcca actgtttcaa
    10741 acagccacat ccatggatca ggattccaag gttctcctgt tgatgcgaat acttccaaac
    10801 tctttaaaga atgtttattg acatactcat caccttttgc cattaatgct cggattaacg
    10861 ttggcgaaat acctagatga gtaatttcat atttatcaac tgtctcccat aaccggtctg
    10921 cttctgggaa gtctggaaca ccttcgtaca taaccatcgt tgctccatta atgagtgaac
    10981 cgaataatag aaacggcccc atcatccagc ccatatcagt tacccataat acacgatcac
    11041 cttgtttaat attcattcca aatcctgcat caaaagctgc tttcaaagga aatcctgcat
    11101 gcgtgtgtac tgttcctttc ggcttaccag tcgttcctga tgtataaatg agcattaatg
    11161 gatcatcact ttgcatttcc tcggcatgta tgaatggttt ttctttttct agcgtactcc
    11221 acgaaaagtc atagttatgt ggtgtaaaat catttcctgc atgacgaacg ataacaactt
    11281 tttcaacagt tgggcaatgt tcacaagctt tatctacttc atcttttaaa gaaacaattt
    11341 taccgcggcg tgaaaatcca tctgcggtaa taatcatttt tgaacctgcc gcttgcacac
    11401 gtgtcataac tgcatcagac gcaaagcctg agaatattgg tgaaataatt gctccaattt
    11461 tcattacagc tagcatcgca acaactgttt ctggaatcat cggcatataa attgttacac
    11521 ggtcaccttt ttcaataccc gcgtgtttca aaccattggc aacacggctt acccagttat
    11581 caagctcttc atatgtaaat gattttgaag ttccattttc tccttcgtac tgaagtgctg
    11641 gctgtattct tgtctcttca tccgcaagcc agcgggataa agctgattct acaacgttac
    11701 atgttccgcc attataccac tgtgcaaacg gtgtaccatt ttctaaatct aacacttctg
    11761 tataaggttt catccattga tagccaactg ctttttctgc ctctccccaa agccaagctg
    11821 tttcctcaat agatttatta taaaaagttt catagtcttc atatcccaat gatttcatcc
    11881 aactatataa acgtgttttt tccttgtact cttctgttgg aaaccaaact gcttgtttca
    11941 atgttttccc ctccttaact ttttgagcaa gaaagcccta aatagggctt ttaaactgga
    12001 tatacaggat gtttacgatc cgtgaatact tgatatttac tcatatacat ttcgaaacgt
    12061 ccttttaact cttcacgtaa attgtttgga tgaacaatac catcaatcac catctctgat
    12121 gctaaatgat aaatatcaat atctttctta tactcttcac gtttttcagc aatgaagcta
    12181 gcacgctctt cttctggtaa agctgcaatt ttatttgcat atacagcatt aaccgcagct
    12241 tctggaccca ttaccgcaat agaggctgtc ggtaatgcca aacagcaatc tggttcaaat
    12301 gctggacctg ccatcgcata taaaccagcg ccatatgctt tacgaacaac gatagaaatc
    12361 ttcggtacag tcgcttcact cattgcagaa atcatttttg caccgtggcg aataatacca
    12421 gcacgctcta cttttgtacc gatcataaat cctggtacat ccgcaaggaa taataatgga
    12481 atatgatatg cgtcgcataa attaataaac ttagcagctt tatcagctga atcatggaat
    12541 aatacgccgc ccttcatacg cggctgattt gcaataatac caactggctt accatcaata
    12601 cgtgctaagc ctgtaattag ctcttgagca aataattttt ttacttcata gaatgaacct
    12661 tcatcaataa ctctattaat gagatctttc atattgaaag gagcattttg attttctgga
    12721 atgatttgtt ctaacgtttt atcgaattgt ttcggttctt ggggtgtaac caatggagtc
    12781 ttttctaagt agttatttgg aaaatatgaa atgtattgtc ttgcttgtgt aatcgcatct
    12841 tcttctgtct tacataaaac atctccgcat cctgatacag agcaatgcat acgagctccg
    12901 cccatctctt ctaaagttac cttctcaccg ataaccatct cagccatacg aggagatcct
    12961 aaatacatag atgcatttcc ttctaccatc attacaacgt cacaaaaggc tggaatatac
    13021 gcaccaccag ctgcagaagg tccaaataac aagcatactt gaggaacttt acctgataac
    13081 tttacttgat tatagaagat tcttcctgca ccgcggcgcc ctgggaacat ttctacttga
    13141 tctgtaatac gtgctccagc agagtcgact aaataaaata acggaacacg tagtttttca
    13201 gctgtttctt gaatacgtaa aatcttttca actgtgcgtg atccccatga tccagctttt
    13261 acagtagaat cattggccat tacacacgca gtacgaccat gtattttacc cgttgccgtt
    13321 acaacgccat ccgcaggtaa gcctgtttgt tcacagttag caaataatgc atcttctaca
    13381 tattcgccat tatcaaatag aagcgctaaa cgatctcgaa caaataattt tccttttgct
    13441 ttattttgct catgatattt cggtgccccg ccttgtttaa ttgtttcaac tcgttcttca
    13501 aatgaattag attgttgttt ttggtctaac atatttactc ccccttatac atcggtttgc
    13561 gtttttcttt gaatgcctgt aatccttcta ttcgatcttt cgtatggatt acaccttcat
    13621 acgcttgttt ttccatttgt aatccggtat gtaaatcaac ttgaatacca tttgaaattg
    13681 cctcttttgc taatcgaaca gcaatcggtc cattactagc aattttctct gctatttcaa
    13741 tcgctttctc ttcaagtaaa ttagctggta caacaaattc tactaaaccg tattcttttg
    13801 cttcttgcgc tgaaatacgt ctacctgtat aaattaattc tttcgctcta ccaacaccaa
    13861 ttaatctcgg taagcgctgt gtaccacctg ctcctggtat aattgcaagt gtcgtttcag
    13921 taagaccaag acttgcagat tcagcagcaa ttctaaaatc acaagctaaa cttaattccg
    13981 taccaccacc aagtgcaatt ccatttatag cagcaataac tggctgtggt aattgttcaa
    14041 ccatctccat agtagtgcga atcatactaa cagcatggcg aacttgttct tcgttcatat
    14101 cggcacgctc ttttaaatct gcaccagcac aaaatgcttt ttcaccagca ccagtcaaaa
    14161 taactacacg cacgtttgaa tcttcactta tttgagttaa tatagtttgt aattcatcta
    14221 ataatgctaa agataatgag tttgcttgtc tttcacgata taacgaaatc tttacaacgt
    14281 gaggtgttac ataatcaact gaaatgtttt gtaattgtag catcttctca cctacttatc
    14341 gttttatgtt gaagcgctct atacacatga ctcggtaatt ggatatttaa tttactttga
    14401 ataaattgac ttgctctcaa taacttctct tcatcaatat tcgtttggac tcctaactta
    14461 tggagcatat gtactaggtc atcagtagca acattacctg atgctcctgg tgcataaggg
    14521 cagcccccga gtccaccaca agaactatca aacgttttaa taccgtattc taatgattta
    14581 actacattcg ctagagccat tccatacgta ttatgaaaat gcattgcaaa ctgcgaagca
    14641 tcatacttct ttaatagatg ttctaatact tgttctactt gtaatggatt cgctacaccg
    14701 attgtatccc caagagaaac ttcataaatg ccgtatgaaa atagttgatt acataattcg
    14761 tcaactgctg tgacacttat atccccttca taaggacatc caaatacagt agaaacatag
    14821 cctcttacct ttttcccttc gaataatgcc tgttttgtta tatcttcaat tacaactaat
    14881 gcttctttaa tcgatttatt aatattactt ttattatgag attcacttgc tgataaaaaa
    14941 acattcacct catctacatt ttgcaaaaaa gctcgttcca aaccattttg attcggaaca
    15001 agcgcagcat atgtaacatt tgggtccctt ttcagctcag aaaatacatc atttgcatct
    15061 gctaatgcag ggacccattt tgggtgaacg aatgaggaaa cttcaacata cgacaatcct
    15121 gcttctgtaa gtagttgaat ccattttact ttatcttttg tgccaacaat ctttttttca
    15181 ttttgtaagc catcacgtgg cccgacttct ttaatgacag caaaattagg tagtttcaat
    15241 tcgcttcccc ctatatctcc ctattcaatt tctaataata catctccttc atttacaaaa
    15301 tcgccttctt gcacattaat tttcataact gtgccagctt cttctgaaat gattggaatt
    15361 tccattttca tagattccaa aatgacgaca tcctgctctt cctctactgt atctcctact
    15421 cctacaacaa tcttccaaac gtttcctgcc attgatgcgt atactttcgt catcattttt
    15481 tcccccttaa tattgttaaa tcttattttt taacgagttg tttcgttaca aaccccgttg
    15541 tataaatacc ctctttgaac acttcgtctt ccaaaacttg cagtagcatt ggcgtgttcg
    15601 ttttaatacc ttctactttt aattcttcta gagcatcatg taatttcgaa attgcttctt
    15661 cacgagtctc gccatgtgca atgactttcg caatcattgg atcatagaaa ggtgtaatcg
    15721 ttacatgatt ttctaagaag tgatcaatcc gtacatttga cggtaatgtt aaatctgtaa
    15781 ttttcccagg tgatgggaag aatgttttcg gatcctctgc ataaatacga gcttcaatgg
    15841 catgaccact acgttttaca tcatcctgag taaatgatag tttctctcca cttgcgataa
    15901 ggagttgctg ttctacaagg tctaatcccg taatttcttc tgtcactgga tgctctactt
    15961 gtaatctcgt attcatctct aagaaataga agttcttctg atcatctaca agaaactcaa
    16021 ctgtacctgc atttgtatag ccaagtgctt tggcagcttg tacagcaact tctcccatcg
    16081 cctttcgtgt accttcatct aaaaatggtg aaggtgcttc ttcgattact ttttgatttc
    16141 ggcgctgtac cgaacattca cgctcccata aatacactgt gttaccatgt gtatctgcta
    16201 aaagctgaat ttcaatatga tgcgtatctg ctatatatcg ctctaaatac atttctccgt
    16261 taccaaagaa gttttgcgct cttgttttat tactttcaaa cgctttggtg agcgtttgct
    16321 cagtttccat caactgcata ccaatgcctc cgccgcctgc ggatgcctta agcattaagg
    16381 gataaccaat ttgttttgca atttcaattg cttcttcagc agtttcaata tttgtagtaa
    16441 tacctgggac tactgggaca tctgctgctt gcattgcgat acgtgattcg attttacttc
    16501 ccatcttcgt aatgatttct tctgaaggac cgataaatac gattccttct tctttgcaac
    16561 gaaccggaaa agacggattc tctgataata aaccataacc cggatgaatc gcttctgcat
    16621 ttgtcttctt agctatttca ataatttttt caaggtttaa ataactttct tgaacacgcg
    16681 gtccacctac taagtaagct tcatttgcca tcttcacatg aagggcattt tcatctgctt
    16741 cagaataaat agcaacagtg cgtatgccaa gtttttgaca agttttcata atacgaacag
    16801 caatttcccc gcgattcgca attaatattt tttgaaacat agtgattcct cccttttatc
    16861 tacatcctaa atgtctagca attacgagac gttgaatttc agaagttcct tcaccaattt
    16921 ctaatagttt tgcatcacga atatgtcgtt caacttcata ttcacgcata taaccatatc
    16981 caccatgaat ctgtactgct tgattcgcaa tacggcttgc tgcttccgat gcaaatagtt
    17041 ttgccattgc cgcttctttg ccgaaaggtt tatcgttatc ttttaaccaa gctgctttat
    17101 gtactaaatt gcgtgctagc tctacttcag tcgccatatc agctaattta aattgaatcg
    17161 cttggaaatt agagattgac tttccaaatt gttgacgttc tttcgcatat tgtaatgcac
    17221 gttcaaaggc tgattgcgca ataccaactg ccaatgcagc gattgaaata cgccctccat
    17281 caagtgtata taaaaattgt ttaaagcctt tatttacatc accaagaata ttttctttcg
    17341 gtacacgaac accatcaagt acgatttcac aagtattaga agcgcgaaca cccatcttat
    17401 cgtaaggact tgaaatcgtt aatccttcac tcgtagtagg cacgataaat gcagaaatac
    17461 gttttctacc attctcttca ataccgttga cagcggttac aataattgta tttgcatact
    17521 ctgcgtttgt aatccaacac ttctcaccac tgattacata ctcatcacca tctaataccg
    17581 ctttcgtttg agtaccacct gcatctgatc cagcattcgg ctccgttaat ccgaaggcac
    17641 ctaatgtttt acctgacgcc attggaacta aatacttttg tttttgttct tctgtaccga
    17701 aataataaat tggagaagca cctaatgaaa ttgttgcagc atagcttaaa ccggtgccac
    17761 cacaagcgcg accaatttct tcaactgcta aagcatacga tactgtatcg ccacctgaac
    17821 ctccatactc ttctgggaat gggatgccta gtaatcctag ttcgcccatt ttttgaaatg
    17881 tttcatatgg aaactctgca gttttgtcat aatatacagc tttcggtgcg atttcctttt
    17941 cagcaaagtc acgtaccatt tctttaatca tttgtttttc gcgagttaga gtaaattcca
    18001 ttccgctaca caccccttat cgaatattga gtttcgacag cgtgcgagtt tctactacaa
    18061 acataacaac ttaaaagaca agaatattag ttagacaatt gctataattc tgtcataact
    18121 taattttaaa acagattctg tactaatgca caaaaaaatt cctacattgt tctacaacaa
    18181 cataggaggt tttgtgtcga attatgtaat ttattgttta ataatctcta ccttttccgg
    18241 aatcagaaat ttctactaat gcttcaggat atggttcgaa atatgtttgt cttaataaat
    18301 acttttcatc aaatcgaata gcccatgatt ttaaaattgt aagtaaacta ctaagtggta
    18361 ttttcttttc tgcatacttt tgtaacagtt ctataaaatg atctttttct tgttttttta
    18421 actttgtttt aaaatatcca aaaatgtgct cacatacatt tacattcgat gtataacggg
    18481 gcgcacgcat aaataattca tataaagtct tctcatagtt ttcaaatacc acttcaatct
    18541 tttcattttt ttgatttgca attatacgac ctaattcctt ttgtttcacc tgattatatg
    18601 ccataaataa atatttatta tccgactgaa acgatacaag ttctttcata tttttattgt
    18661 gtttaatcat tttgtaatat gcgattgtaa atagccttgt aaagaaatgc tctctaataa
    18721 taaaattcga caatctacct tcctcttcaa taggaagata cgaaaaattt tttactactg
    18781 ctccgccaaa taagccagct ccttttccct ttgctggcgc tttttcaaaa ccagaataaa
    18841 ttttcacatc acgcgtacca caacttggtg aacgattctt taaaataaaa ccatccacat
    18901 ccgatatcgt ttgtaaaaag tcatttgaaa actgctccat tttttcagtt acatcttctc
    18961 gtgtcgacgg ttgcacaagt ctattctcac cattttcttc tacaattcgt atcgtttcac
    19021 gaggagtccc caatccaatc tcgacttctg gacaaacagg tataaatgta acaaatggct
    19081 gcaaatttcg tattgttaca tctggaatca tctctccatt ataacgacaa gcatcaaatt
    19141 ctaaacattt acttacgacg attgtaggtt ttgcaaattg tcgcatctta ttacctcctt
    19201 attactagtc cgtataatat aaattgtact aagattaaca ttttaagcaa agtttgattc
    19261 agttattttt atgagaaata taaatccaat gatacattaa caatcattca actctatttt
    19321 ctataaatgt gcgccctatt aatgagggtt tagatattgt gaaatgaata atacacacat
    19381 gcttcggaga aattaatgat taagaaagga gggattgtta tgaaaaagaa attatcatct
    19441 attttgagtg ttttaacact atctattatg tttttaggta catctacgca agctgaatac
    19501 gatggaaata atatgaatag agttaataac actgatattt caactcgagt aaatgacaat
    19561 aacttagaca gagttaataa tgatgtaaga actcgaaatg taaatacaac aaatgattta
    19621 aatgataatc gtgataaaaa taataattgg gcttggcttg gtttattagg actagcagga
    19681 ttattaggtc ttagaagaag agacaaagaa acacgctgat ttagaatgtt tttagtaaac
    19741 aagcacttat ttatcaaaaa tatataatga aaataaatcg cctttttaaa ggcgatttat
    19801 ttttcagagt gttgggaaa
//
