LOCUS       NZ_NTWJ01000003        23507 bp    DNA     linear   CON 01-APR-2024
DEFINITION  Bacillus thuringiensis strain AFS009835
            AFS009835_104_C9_Contig3_140523, whole genome shotgun sequence.
ACCESSION   NZ_NTWJ01000003
VERSION     NZ_NTWJ01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus thuringiensis
  ORGANISM  Bacillus thuringiensis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 368755)
  AUTHORS   Bleich,R.M., Kirk,G.J., Santa Maria,K.C., Allen,S.E., Farag,S.,
            Shank,E.A. and Bowers,A.
  CONSRTM   Agbiome Team Llc
  TITLE     Large-scale bioinformatics analysis of Bacillus genomes uncovers
            conserved roles of natural products in bacterial physiology
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 368755)
  AUTHORS   Bleich,R.M., Kirk,G.J., Santa Maria,K.C., Allen,S.E., Farag,S.,
            Shank,E.A. and Bowers,A.
  CONSRTM   Agbiome Team Llc
  TITLE     Direct Submission
  JOURNAL   Submitted (07-SEP-2017) Chemical Biology and Medicinal Chemistry,
            UNC Chapel Hill, 125 Mason Farm Rd., Chapel Hill, NC 17599, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Assembly Cell v. 4.2.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 61.85x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002562205.1-RS_2024_04_01
            Annotation Date                   :: 04/01/2024 01:49:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,978
            CDSs (total)                      :: 5,906
            Genes (coding)                    :: 5,721
            CDSs (with protein)               :: 5,721
            Genes (RNA)                       :: 72
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 185
            CDSs (without protein)            :: 185
            Pseudo Genes (ambiguous residues) :: 0 of 185
            Pseudo Genes (frameshifted)       :: 82 of 185
            Pseudo Genes (incomplete)         :: 109 of 185
            Pseudo Genes (internal stop)      :: 57 of 185
            Pseudo Genes (multiple problems)  :: 52 of 185
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:13:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 100998
            Orig. end                         :: 124505
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NTWJ01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23507
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23507
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23507
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13507](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13507
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    259..273
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 23.38"
                     /tool="antismash"
     tRNA            408..480
                     /anticodon=(pos:101439..101441,aa:Val,seq:gac)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="CN427_RS02010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="CN427_02010"
                     /product="tRNA-Val"
     gene            408..480
                     /locus_tag="CN427_RS02010"
                     /old_locus_tag="CN427_02010"
     gene            complement(542..1138)
                     /locus_tag="CN427_RS02015"
                     /old_locus_tag="CN427_02015"
     CDS             complement(542..1138)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002126039.1"
                     /locus_tag="CN427_RS02015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02015"
                     /product="DUF4878 domain-containing protein"
                     /protein_id="WP_001169482.1"
                     /transl_table=11
                     /translation="MQKIKKLLLLMMVVGLTAGVLAGCANPKDTTEEFLTAIQKGDVEK
                     ARTFVESDKEFNKLNEKTDDAEAKAMLSAITKNFKFEKLEEVSKKDDKAEVKVKITSAD
                     LSVAVTKAVGEVMPMAFASAFSEDKEQSEKAIEKTMTSTIVKNLADKDAAMATREVTLN
                     LKKDKDGDYKIVADDNLKEVLFANAKSLEKMFGGK"
     gene            complement(1297..1842)
                     /locus_tag="CN427_RS02020"
                     /old_locus_tag="CN427_02020"
     CDS             complement(1297..1842)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002168863.1"
                     /locus_tag="CN427_RS02020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02020"
                     /product="hypothetical protein"
                     /protein_id="WP_001267321.1"
                     /transl_table=11
                     /translation="MRWKAGTFEKIETNDSSIEKLIHTFKEQNVNGGVVISCFKVHNEN
                     FFKEIPYWKDGHEHFFRRIFNSLDIINSLEELKIHTSEKYKLHFKEQWAVMLDGSIAAQ
                     ILSGGAYEGFKERPVIAKQLAVNVCQYMFQDRYEDIKVFKSYCPWTDWFYDVAWDATWM
                     VLDSRERKMWFICATDTD"
     gene            complement(1924..2138)
                     /locus_tag="CN427_RS32050"
                     /old_locus_tag="CN427_02025"
                     /pseudo=""
     CDS             complement(1924..2138)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001195387.1"
                     /locus_tag="CN427_RS32050"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02025"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFVFFLLSVPLTF"
     misc_feature    2179..2193
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.57"
                     /tool="antismash"
     gene            complement(2194..2556)
                     /locus_tag="CN427_RS02030"
                     /old_locus_tag="CN427_02030"
     CDS             complement(2194..2556)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036573.1"
                     /locus_tag="CN427_RS02030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02030"
                     /product="hypothetical protein"
                     /protein_id="WP_072939673.1"
                     /transl_table=11
                     /translation="MNKKTIFYLLTCILLVASTTYIICNKREQVPPILVWDEQEYYVTN
                     EPAKVEEVGQKLGEVTKKIKTSKKPTKNRESNTLQEKTEVFIMIEEEKSDYPSLIIKEA
                     YSDEYRVVRPMLKQVL"
     misc_feature    2604..2618
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 24.63"
                     /tool="antismash"
     gene            complement(2689..2871)
                     /locus_tag="CN427_RS02035"
                     /old_locus_tag="CN427_02035"
     CDS             complement(2689..2871)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002086895.1"
                     /locus_tag="CN427_RS02035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02035"
                     /product="DUF3976 domain-containing protein"
                     /protein_id="WP_001178294.1"
                     /transl_table=11
                     /translation="MQMMYAFGIGLVLFLAVFLFIRKDVQGGTLTKRGFYKLIGCLVVM
                     LIAIIVMIVLINQSL"
     gene            3700..6567
                     /gene="odhA"
                     /locus_tag="CN427_RS02040"
                     /old_locus_tag="CN427_02040"
     CDS             3700..6567
                     /EC_number="1.2.4.2"
                     /codon_start=1
                     /gene="odhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000197121.1"
                     /locus_tag="CN427_RS02040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02040"
                     /product="2-oxoglutarate dehydrogenase E1 component"
                     /protein_id="WP_072939677.1"
                     /transl_table=11
                     /translation="MTRKNTTTNPWAKFHGPNLGYVIEQYDLYVTGAGSVDPELQELFE
                     IFGAPSFQDDVVTGDNTATHFSPQNTGNIEKILKVVQLVEQIRSFGHTLAHINPMEDAA
                     NGQSLLEKAMNELSDADLKAFPAKTVWQDAPEGIHTALDVIHRLKDVYTKSLAYEFSHI
                     QDSEERAWLHQMVESNSLRQPLSNKKRTALLKRLTAVEGFEQFLHKTFVGQKRFSIEGV
                     DMLVPVLDEIVLEGAKNGVEDVMIGMAHRGRLSVLAHVLEKPYSHMFAEFKHAKIEGAV
                     ANSGWTGDVKYHLGREQVVSNEEVSTRVTLANNPSHLEFVNPVVEGFARAAQENRKKSG
                     LPDQDTSKSFVILVHGDAAFPGQGIVSETLNLSRLNAYQTGGTIHVIANNAVGFTTDSY
                     DSRSTKYSSDLAKGFDIPIVHVNADDPEACLAAANLAIQYRMLFKKDFLIDLIGYRRYG
                     HNEMDDPAVTQPQVYKKIKNHPTVRAIYADQLQAAGVLNADEVETITQFIQEQLKSDYA
                     QVPPADTSDATIHVKVPDVVAKGIQSIDTGVEIDSLRAINEGLLSWPEGFNVYPKVKKI
                     LERRKDALEENGKIEWALAESLAFASILQEGTPIRLTGQDSQRGTFAHRHIVLHDTDTN
                     ETYSPLHRLPNINASFSVHNSPLSEAAVVGYEYGYNVFAPETLVMWEAQYGDFSNTAQA
                     LFDQYVSAGRAKWGQKSGLVLLLPHGYEGQGPEHSSARPERFLQLAAENNWTVANLTSA
                     AQYFHILRRQASILGTEAVRPLVLMTPKSLLRHPLTLSTASQLSEGRFQPALEQENLGM
                     KPNKVKRLVLSTGKMAIDLAAEIESGKHEYNLDEVHVVRIEQLYPFPAEKVQSIIKRFK
                     NLEEIIWVQEEPRNMGAWHYMAPILFELAGDKVKTGYIGRPDRSSPSGGDPFAHKAEQE
                     LIVAHALDVKYNFRQDKQEIEVYSN"
     gene            6701..7960
                     /gene="odhB"
                     /locus_tag="CN427_RS02045"
                     /old_locus_tag="CN427_02045"
     CDS             6701..7960
                     /EC_number="2.3.1.61"
                     /GO_component="GO:0045252 - oxoglutarate dehydrogenase
                     complex [Evidence IEA]"
                     /GO_function="GO:0004149 - dihydrolipoyllysine-residue
                     succinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="odhB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016716916.1"
                     /locus_tag="CN427_RS02045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02045"
                     /product="2-oxoglutarate dehydrogenase complex
                     dihydrolipoyllysine-residue succinyltransferase"
                     /protein_id="WP_000569893.1"
                     /transl_table=11
                     /translation="MIEIKVPELAESITEGTISQWLINVGDKVEKGGSVVELETDKVNV
                     EIIAEDSGIVSKLLGEPGDTVEVGATIAILDANGAPVAVSTPAPAAEQPKQETAEAPKA
                     AAPNAEQTTGLQGLPNTNRPIASPAARKMARELGIDLNDVRSTDPLGRVRPHDVQAHAA
                     APKEAPAAPKSPAPAPVAKTEFEKPVERVKMSRRRQTIAKRLVEVQQTSAMLTTFNEVD
                     MSAIMELRKERKDAFEKKHDVRLGFMSFFTKAVVAALKQFPLLNAEIQGDELIIKKFYD
                     IGIAVAAPDGLVVPVVRDANQLNFAEIESEIRNLGMKARDNKLSLKELQGGTFTITNGG
                     VFGSLMSTPILNSPQVGILGMHKIQVRPVAIDNERMENRPMMYIALSYDHRIVDGKEAV
                     SFLVAVKDMLEDPKSLLLEG"
     aSDomain        8085..8384
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CN427_RS02050_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="7.90E-58"
                     /identifier="RREFam011.1"
                     /label="CN427_RS02050"
                     /locus_tag="CN427_RS02050"
                     /protein_end="100"
                     /protein_start="0"
                     /score="183.5"
                     /tool="antismash"
                     /translation="MNNLPIHAKLKVNKDTFFLPDSNGGVYFRNNASSFRMDGDGIYDW
                     IEKLMPMFNGNYSLAEITEGLPLPYQNRVFEIGEVLYENGFVRDANQDAPHELNS"
     gene            8085..10004
                     /locus_tag="CN427_RS02050"
                     /old_locus_tag="CN427_02050"
     CDS             8085..10004
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03693"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016513905.1"
                     /locus_tag="CN427_RS02050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02050"
                     /product="putative thiazole-containing bacteriocin
                     maturation protein"
                     /protein_id="WP_001061569.1"
                     /sec_met_domain="TIGR03693 (E-value: 0.0, bitscore: 1220.7,
                     seeds: 2, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     1.1e-56, bitscore: 183.5, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 4e-12,
                     bitscore: 40.6, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLPIHAKLKVNKDTFFLPDSNGGVYFRNNASSFRMDGDGIYDW
                     IEKLMPMFNGNYSLAEITEGLPLPYQNRVFEIGEVLYENGFVRDANQDAPHELNSSLLD
                     RYASQIEFLEADSHSGALKFETYRGANVLVLGSGDMLTSLVSSLLESGLPTFHYLVTDR
                     DETNYDRIHELIERAYEVDNNVLLQEIDTTIDRPLHEVFEPFDWILYVSQNGDIDGLKT
                     VHTICRETKKNFIPAICLSTLGIAGPVVTENRDECWESAWHRLHETTLQNENSSDSFSP
                     ITSAMLTNVIVFELFKHVADDSYREKESQFFLLNYETLEGTWHPFIKHPLAADESFTID
                     TIENLSEKLEHRSNQHTSTDVFRFFDSLTSKEAGIFHVWDEQDSYQLPLSQCYIQVATP
                     LSDGPAPLLPLMTRSGLTHNEARREAGLTGIETYVAEIIHRLIPEHNDIGIGAGETMTE
                     GFYRALQQHLNNKLYERQSHMLEELTTIDLTDIHDKHCRFYYDALATIHETPKIAMSEE
                     ILSFPVVWVGINDRWYGASNINMTLALRNALQLSLFHIQNEEIPYRANILYDSSIILYD
                     TDSLRVEIQPEEEIPSVQSLQLALQHLEEHNFYPFVFDLAIEPFLKENLDGVYGVLIAK
                     EDGL"
     aSDomain        8115..8351
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CN427_RS02050_Thiopeptide_F_RRE.1"
                     /evalue="2.90E-13"
                     /identifier="RREFam004.1"
                     /label="CN427_RS02050"
                     /locus_tag="CN427_RS02050"
                     /protein_end="89"
                     /protein_start="10"
                     /score="40.6"
                     /tool="antismash"
                     /translation="KVNKDTFFLPDSNGGVYFRNNASSFRMDGDGIYDWIEKLMPMFNG
                     NYSLAEITEGLPLPYQNRVFEIGEVLYENGFVRD"
     gene            10001..11950
                     /locus_tag="CN427_RS02055"
                     /old_locus_tag="CN427_02055"
     CDS             10001..11950
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191877.1"
                     /locus_tag="CN427_RS02055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02055"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_097853700.1"
                     /sec_met_domain="YcaO (E-value: 3.5e-85, bitscore: 281.2,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 2.2e-144, bitscore:
                     475.5, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQNILLIGDGLLADYVHDQLCKQYSIIRQHTLTEELPENIHLAL
                     VLHDGSPSTIHHDAELIFRSNHIPWLRGFTSFGEGIIGPYIHPLTPGCSHCSDGRRFIA
                     GFDQKEMWELQRKYAFKADNVTRRDVRATQNGMLQMCHLICAETEKILTHNHSSLENEL
                     ILLNLQTLQCTRHSFLPDPLCPVCSNLPDDTADAAEVSLQPSLKVSTETYRCRSIHELN
                     TFLTKDYLDYRIGMLNGKMQHSLLPFADVIINMPLMFGNEGVAGRTHSFAVSEATAILE
                     GLERYCGMSPRGKKTNVHGSFHDLEEHALNPLTLGVHTNEHYNRDNFPFKPFDPDYEQN
                     WVWGYSLSQNRPLLVPESIAYYSLGHRDAFVYETSNGCAIGGSLEEAIFHGILEIVERD
                     AFLLTWYAELPLPRLDLSSANDTELQLMIQRLRTITGYELHAFNATMEHGIPSLWVIAK
                     NTRENGMNVVCAGGAHLDPIRALKSAIQEIAGMLLITDDELEHKREYYEKCLQDPYFVN
                     KMEDHSMLYGLKETEERLHFLLREDAPVQTFQEMNVSQSFDMDLTSDLHQLLNRLHQSN
                     LEIIVVDQTVPLIEKNGLHCVKVIIPGMLPMTFGHHLTRVTGLDRVYTVPMTLGYSTEP
                     LTNEQLNPHPHPFP"
     gene            11966..13507
                     /locus_tag="CN427_RS02060"
                     /old_locus_tag="CN427_02060"
     CDS             11966..13507
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016124293.1"
                     /locus_tag="CN427_RS02060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02060"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_097853699.1"
                     /sec_met_domain="PF00881 (E-value: 1.1e-09, bitscore: 33.2,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLDTFLHHLHFSIDEIMPNHEVDWKDAPLPYKLYRNVPTIPLSL
                     EIPLSLSNSSTTPTLNEIGHYLWYSFGVTQLCQLNSERNVLRRSIPSGGALYPNELYIY
                     LKIDDYPDGIYHYDAAHHRLILLREGNFDSYLADALGNRCNIHDCFGAAFVSTMFWKNF
                     FKYNNFSYRLQGLDSGVLIGQLLECAKQFGYTNGVYFQFLDRALNHLLGLSEGEESVYA
                     VIPLGTEPETNWFHNDYRENKTVTSHELLQQIPPLAHEHFVRSKHVNEHPMITKINEAS
                     MIESTEHFQTLHHEEHYQHNTYAVQLPKVERLSYDFLQLCKKRYSPDADFILRKWDAAE
                     LATLLQEASLSFPYYSDLDGKYVNENARVSLYGCFYNVKDIENGAYTYNRKTHSIQPIR
                     YGDLRYLLQSSMTMDNVNLFQVPLCLHVVGKKDYYTNALGYRGYRIHQMEAGILVHKLV
                     FAATAMGMGGHPLLSFDTNSCDQLYGIDAGNETSLIQVPVGAYRARNWLKGALHN"
     gene            13600..14190
                     /locus_tag="CN427_RS02065"
                     /old_locus_tag="CN427_02065"
     CDS             13600..14190
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (49-149). E-value: 2.4e-10. Score:
                     31.0. Matches aSDomain: nrpspksdomains_CN427_RS02065_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016109564.1"
                     /locus_tag="CN427_RS02065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02065"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_072939686.1"
                     /transl_table=11
                     /translation="MNILQRLIQQAKNPRGTIGSSMLCIMNAAHMRLTNWGLQKIHIRK
                     DAITLDIGCGGGKTIHTLSKRIPFGKIYGIDYSDQAVENSKKANIQDVKKGKVIIHQAS
                     VSSIPYNTNFFDLITAFQTHYFWPDVEQDIKEIFRVLQPNGSFLLVAETFKIQYHMEKW
                     KTNEELINLFYKTGFTSVKCYEEGGCLCVIGIK"
     aSDomain        13747..14046
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CN427_RS02065_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.40E-10"
                     /label="CN427_RS02065_oMT.1"
                     /locus_tag="CN427_RS02065"
                     /protein_end="149"
                     /protein_start="49"
                     /score="31.0"
                     /tool="antismash"
                     /translation="LDIGCGGGKTIHTLSKRIPFGKIYGIDYSDQAVENSKKANIQDVK
                     KGKVIIHQASVSSIPYNTNFFDLITAFQTHYFWPDVEQDIKEIFRVLQPNGSFLL"
     gene            complement(14220..14630)
                     /locus_tag="CN427_RS02070"
                     /old_locus_tag="CN427_02070"
     CDS             complement(14220..14630)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000996799.1"
                     /locus_tag="CN427_RS02070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02070"
                     /product="DUF3908 family protein"
                     /protein_id="WP_072939689.1"
                     /transl_table=11
                     /translation="MAINMKTIEEWIVESNTRHEEDFGHVVEEMKEVCVGLDNATLIYT
                     KNVFCFGKKVEVFFFFQDHVVIGKEKDEYIEIEKLKYDDITNNNLKTNDKNTTLELKFA
                     NGQSINLDSLNDNYGTKNWLFARQIKSIFKLI"
     misc_feature    complement(14911..14925)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.04"
                     /tool="antismash"
     gene            complement(14927..15415)
                     /locus_tag="CN427_RS02075"
                     /old_locus_tag="CN427_02075"
     CDS             complement(14927..15415)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002135035.1"
                     /locus_tag="CN427_RS02075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02075"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_072939692.1"
                     /transl_table=11
                     /translation="MIVALQKVQESEKEILRNLYALYLHDLSKFTMNITIGANGFFEYE
                     DLHIFWKNDGITPYFIKVDHSIVGFLLLLERPFLKKENDFGINDIFILNQYKGKGIGKQ
                     AVENLLEEKRGQYFVIELLKNVPAVSFWKKVYKELNIEFDERAQLIDDEECLVQTFKF"
     gene            complement(15516..16850)
                     /locus_tag="CN427_RS02080"
                     /old_locus_tag="CN427_02080"
     CDS             complement(15516..16850)
                     /EC_number="1.8.1.14"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001110220.1"
                     /locus_tag="CN427_RS02080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02080"
                     /product="CoA-disulfide reductase"
                     /protein_id="WP_001110233.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.7e-66, bitscore:
                     217.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYVIIGGDAAGMSAAMQIVRNDENANVVTLEKGEIYSYAQCGLP
                     YVISGAIASTEKLIARNVKTFREKYGIDAKVRHEVTKVDTEKKMVYAEHTKTKDVFEFP
                     YDRLLIATGVRPVMPEWEGRELQGVHLLKTIPDAERILKTLETNKVEDVTIIGGGAIGL
                     EMAETFVELGKKVRMIERNDHIGTIYDADMAEYIHKEADKHNIEILTNENVKAFKGNER
                     VEAIETDKGTYKADLVLVSVGVKPNTDFLEGTNIRKNHKGAIEINAYMQTNVQDVYAAG
                     DCATHYHVIKEIHDHIPLGTTANKQGRLAGLNMLDKRRAFKGTLGTGIIKFMDLTLART
                     GLNEKEAKGLHIPYKTVKVDSTNMAGYYPNAKPLYLKLLYRSDTKQLLGGQVIGEEGVD
                     KRIDVIAMALFNKMSIHDLEDVDLSYAPPYNSVWDPIQQAARRAE"
     gene            17051..17479
                     /locus_tag="CN427_RS02090"
                     /old_locus_tag="CN427_02090"
     CDS             17051..17479
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001978351.1"
                     /locus_tag="CN427_RS02090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02090"
                     /product="hypothetical protein"
                     /protein_id="WP_000332398.1"
                     /transl_table=11
                     /translation="MCAGLLAQFPEEPKEPKPALSLDQEFSINATIYSARAWLSNDETF
                     PQTIWKGSHFASASHAGKSILPIGTVKILNLSDDTITVTASSESDDTLKIVVPPHSEGV
                     LTSNALSDVQASTSGGASKVTFLFHIFFSRDPGSDKKP"
     gene            complement(17519..18719)
                     /locus_tag="CN427_RS02095"
                     /old_locus_tag="CN427_02095"
                     /pseudo=""
     CDS             complement(17519..18719)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017672808.1"
                     /locus_tag="CN427_RS02095"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02095"
                     /product="YARHG domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNVCTKCGVQFEDGVQFCQNCGMKRGSPVVKKNMSSGTKVGITLL
                     ALFVIAIIGLYLYGSSYYTQVAQVDRMITILQERDGEKLAEIVTADDPSVMITRESVTP
                     LFSYIKENPSYVNELKEYLRQGEKQRDGIERADFSLTKDGKYFFIFDRYKLKAKTYYTT
                     LLTNEKGVALKMNGKEIDKTDDKKFEKQYGPFLPGNQVFQSEYKNDYVKLSREEKVVLM
                     KQSQNNVTIDLTLQGQYITVQTNAPGATLYVNQKPVTALIGEEITWGPVATDGSATIYL
                     ERNGESGRETTQVETVTALSSYNLPFQKKSTEKTVVYNVIPPPTTGYVYNGFIFPDSDI
                     RKLTSADLTYLSKEQLKIARNEIYASVFCKTVLV"
     gene            complement(18739..19524)
                     /locus_tag="CN427_RS02100"
                     /old_locus_tag="CN427_02100"
     CDS             complement(18739..19524)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000650096.1"
                     /locus_tag="CN427_RS02100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02100"
                     /product="zinc-ribbon domain-containing protein"
                     /protein_id="WP_000650084.1"
                     /transl_table=11
                     /translation="MKCPSCHTEHAVEAKFCGNCGHSLTEEVVASSGKEEGQEQARAAQ
                     EKETRPNETVEQAKRFASGYFQFFKHALQAPTAIMKSGTIEVRNGIVSLVLICFLGACI
                     FYRMMSAASAVTRTFAPDISTPTFFGESITVFFFLLILTLFVGFIIFVSGKMMKSSFSF
                     LEVFGIWGTIATPAIVILVLSFLFSFLLIFFLPILLSVVATYIGISITVAVLKLDNGGL
                     DLVYTLIIANVLIGIATFIVLWSYISTIIQALTQGITGF"
     gene            19721..20554
                     /locus_tag="CN427_RS02105"
                     /old_locus_tag="CN427_02105"
     CDS             19721..20554
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017762920.1"
                     /locus_tag="CN427_RS02105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02105"
                     /product="hypothetical protein"
                     /protein_id="WP_000424523.1"
                     /transl_table=11
                     /translation="MELVNSIFQILLTSVIQLLSLIGVIIVIGFLLGYLESLTRMYWSR
                     AFGRKGFLLTAWIGVPIHELGHAIMCVLFRHKIVATQFFPTDTSQGALGYIQHQYNQKS
                     VYQRIGNFFIGIGPIISGITALILLMRYFVPESYFLFNTTLEKTIASTSINVEMIQNML
                     LSTFVLLKSLFTIGNLLNPSFWLFLFIAICISAHIALSKPDIKGSIDGVVVMFIVLFLF
                     NIIAGLFQYNSNQLIGQVMKYNMYLIAFSSVALLFSCLSTLVSFSFYKIRRGRSF"
     gene            complement(20569..21252)
                     /locus_tag="CN427_RS02110"
                     /old_locus_tag="CN427_02110"
     CDS             complement(20569..21252)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001128607.1"
                     /locus_tag="CN427_RS02110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02110"
                     /product="YukJ family protein"
                     /protein_id="WP_001128610.1"
                     /transl_table=11
                     /translation="MPLKNYGVLKGTVIQSKIGKGKTPHYQVHLQGETGVDYRIAINVK
                     SQSYPSEVLYFASNNIRSEAIHILPTLPFGFTEVKNNEPKVALDYVRGNLFDSKQMIPL
                     PPEKAGADNDLNEKIERYIKRAMEEKAIIYAFGERWGPEENTPDSYFHFKPGNGIHDIH
                     MNQGNVEKWKADNGIWQDGGILIHFEKEEEWIGIFLAFQSQSWCTDEEGHARVPVEHCD
                     YKGNN"
     gene            complement(21343..22842)
                     /locus_tag="CN427_RS02115"
                     /old_locus_tag="CN427_02115"
     CDS             complement(21343..22842)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015129 - lactate transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015727 - lactate transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002126004.1"
                     /locus_tag="CN427_RS02115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02115"
                     /product="L-lactate permease"
                     /protein_id="WP_000996260.1"
                     /transl_table=11
                     /translation="MAILLALIPIMMIFICLFLFKQTSLRSSLISYAVSVGIVLLSPTF
                     QLGISETVHATIKGWLICFIVGYVLFFGIFLFHLMNKMGYIDQVARFLEEVTQDRLLQM
                     LLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMATGTI
                     IGSQLINMPLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGVGFFLLFSLG
                     IYLSNAYVSVELAGILSSIVTITFGFLIIKLKGKSGQNLITEHAAATEREVSIIKIISP
                     YIFLTVCILLSRLVPALHDLFRSYAVLDLKSYSYKLELLYSPGFWLGMTCLFTIIFFRI
                     PSNIIKQSLSQTIKQWIPFAITTTMFIAISELMGASGMHLLLAKTAGETFGTFFVFVAP
                     FIGAIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITL
                     GAYLCNIPYRENELLKKTTLMIFGAVLLVMVEVIVWYMLRN"
     misc_feature    22798..22813
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.85"
                     /tool="antismash"
     misc_feature    complement(22934..22948)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
     misc_feature    22935..22949
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.41"
                     /tool="antismash"
     gene            complement(22957..23316)
                     /locus_tag="CN427_RS02120"
                     /old_locus_tag="CN427_02120"
     CDS             complement(22957..23316)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016082428.1"
                     /locus_tag="CN427_RS02120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN427_02120"
                     /product="DUF4029 domain-containing protein"
                     /protein_id="WP_000946150.1"
                     /transl_table=11
                     /translation="MLRRKLLYLLLTVPLYAWLISMTKIELMALFLGYVFIFSNLNRIQ
                     EQSILEICLFSISIELFSIVSIVLLNELFLRIHSFTLMKFWNIALQAICTYIVFVVLKK
                     IIGQQTVFQDNRKWE"
     misc_feature    23346..23364
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.43"
                     /tool="antismash"
ORIGIN
        1 atgaaattgc aactttcaca ggatatggcg atgatattta tgaggatgga acatatcgtt
       61 ataaagtcga aataaaaggc gctgacggtt ctattgatac aatttacaca gcaggaatga
      121 cagttacagg acgatagctt atgaacaagc tccattattt atgattgtat ttttgaaaat
      181 atcattgata attgcgttga tattattatt aaaataagct cttcggggct tattttttta
      241 tacaaaaatt agaatatgaa cattcagaaa attacacctt tacaccatta aagtttgttg
      301 ctattatagg aatacatcaa atgttacaat actcaacaaa ttgtacaaat tctccgatta
      361 cacgaatgaa atgaaaatac attgctgatg gtaacattta tagttgggat cccgtagctc
      421 agcagggaga gcgccacctt gacagggtgg aggtcgtgag ttcgagcctc tccggggtca
      481 taaaaaagag acaccatatc aaccttctac gtgatatggt gtctcttttt atctaattca
      541 attacttccc accaaacatc ttctccaaag acttcgcatt ggcaaacaat acttctttca
      601 agttatcgtc agcaacgatt ttataatcgc catctttgtc tttctttaag ttcaatgtaa
      661 cttcgcgagt tgccattgct gcatctttat ctgctaagtt tttgacgata gttgatgtca
      721 ttgttttttc gattgctttt tcagattgtt ctttgtcttc actaaaggca ctagcgaacg
      781 ccattggcat aacttctccc actgcttttg ttacagcaac ggatagatct gcagatgtaa
      841 ttttcacttt cacttctgct ttgtcatcct ttttcgatac ttcttctagc ttttcaaatt
      901 taaagttctt tgtaattgca cttagcattg cttttgcctc agcatcatct gttttttcat
      961 ttagtttatt aaattccttg tcactctcaa caaatgtacg agccttttct acatcacctt
     1021 tttgtatcgc tgttaaaaat tcttctgtag tatctttcgg atttgcacac cccgctaaaa
     1081 cacctgctgt taatcctact accatcatta atagcaataa tttctttatc ttttgcacgt
     1141 tcattcacct cttatctttt ctagtaagtc agcatcatac aatattatga aactgacatt
     1201 acaaacattt tttagtatag catttatatg attcgttttc tattaattcc caaaagataa
     1261 agggccttgc agcattccta caaggcccct cttctatcaa tctgtatccg tagcacaaat
     1321 gaaccacatt ttacgctccc tactatctaa caccatccaa gtagcatccc atgcaacatc
     1381 gtaaaaccaa tctgtccaag ggcaatagct tttgaacact ttaatatctt catagcgatc
     1441 ttggaacata tattgacata cattcacggc taattgtttt gcgataactg gtcgttcctt
     1501 aaatccttca tatgctccgc ccgacaaaat ttgagcggca atgctaccat caagcatgac
     1561 tgcccattgc tctttaaaat gcaacttata tttttctgac gtatgtattt ttaactcttc
     1621 taagctattg attatatcta aagagttaaa gattcttcta aagaagtgct cgtgtccatc
     1681 tttccaatat ggtatttctt taaaaaaatt ttcgttatgt actttaaaac agcttataac
     1741 cactccgcca tttacgtttt gttccttaaa tgtatgtatg agtttctcaa tagatgagtc
     1801 attcgtttct attttttcaa acgttcctgc tttccatctc ataacgccca ctactctcta
     1861 ttcaaaattt gtttcttaat tataaatatc aaaataaaac ccagcaactt taagattgct
     1921 ggattatctc ttatttatat ttaaaaaaac aataacaatt gctccaatta tataatgccc
     1981 tgctaccatc cacatactcc gatcaaaaat cataagcgat aaccagagtg atatattcat
     2041 agtagcaaat aataaatata aaatgtaatc tctcttttgt attgctcctc tattcatcaa
     2101 aatgtaagcg gcaccgatag gaggaaaaag acaaatattt ttcttaacga ctacggatgc
     2161 ggagttagtg tctgcatatg aacctccttt tcatcataat acttgcttca acatcggcct
     2221 cactacccta tattcatcac tataagcttc ctttatgatt aaagacgggt aatcactttt
     2281 ttcttcctca atcattatga atacttctgt tttctcttgt aatgtattag attctctatt
     2341 tttagtaggt tttttacttg ttttaatttt ctttgttact tcgccaagtt tttgcccaac
     2401 ttcttctact ttggcaggtt cattcgtaac atagtattct tgttcgtccc atactaatat
     2461 aggtggcact tgttctcttt tgttacatat tatataagta gtactagcta caagtagtat
     2521 acaagttaat aaatagaaga tagttttttt attcatatac tacactcctt atctatcatt
     2581 tcattggatt atataacaca atttattttc agaaaatgga tttggtggta attttcaggt
     2641 tgaacaataa agaaaaacct taccaaagta aggttccgtt tttacattct atagtgactg
     2701 attaattaat acgatcatta caataattgc tataagcata acaactaaac agccgattaa
     2761 tttataaaat cctcgcttcg ttaatgtccc accttgaacg tctttacgaa taaataagaa
     2821 tacggctaaa aataatacaa gcccaatgcc aaaagcatac atcatttgca tatgttaatc
     2881 ttcctttctc tcctccatct taatatcttt ttgctaaaac aacaaatgag ataaagacgg
     2941 tactcattgt aagtgccata agtatattca ataatataga agaaactttt ttaaatttca
     3001 gcacgtctat tttgaagcga aacacggaac actgtaaata actgttacta tatctcctca
     3061 cttctttttt taaaatttaa tatctccata tttgttttat ccttttaaaa tatttcattt
     3121 atttctttat ttcacgaaat gcgttatttg ttttacggtg tttttcgtca tatttataga
     3181 aactaactgt ttatggagca ttttttatgt ttagcaactt tttttgtaga aatccttcac
     3241 tttcctttca atatttaaca ctatctaaat aaagtttacg ataaattcat aattttttat
     3301 tttttatact atattccgtt atattgttgt ataatatcta tgaaagcgct tattatttca
     3361 atatacataa ttcaaactgt ttttatcgaa acattctaac tattatacct atatttaaat
     3421 gcaacaatta tagctattag tataggcata ccaaatatat ccaccccatt tttctgtaaa
     3481 attactttat aacatgaaag attaacttgg gtgataagtt attgtgaatg tttttttaca
     3541 aaacagataa gtaatagtgt ttggtattat gtaaattatt gtaataacat aagagtaaag
     3601 aaaaacattt acattgatta ttgattcatt acttattgaa aaagagcaaa atgcaccttt
     3661 gtatggaaaa ggattatatg cattgggagg tttaaacaaa tgacgaggaa gaatacaacg
     3721 acaaaccctt gggcaaagtt ccacggtccg aaccttggtt atgttattga gcagtatgat
     3781 ctttacgtaa ctggagcagg ttctgttgat ccggaattac aagagctttt tgaaattttt
     3841 ggagctcctt cgtttcaaga tgatgtcgta acaggggaca acacagcaac acatttttct
     3901 cctcaaaaca caggtaacat tgaaaaaatt cttaaagtcg ttcaacttgt tgagcagatt
     3961 cgttctttcg ggcacacgtt ggctcacatc aacccgatgg aagatgctgc aaatggacaa
     4021 tctcttcttg agaaagcaat gaacgaactg agcgatgctg acttgaaagc gtttccagcg
     4081 aaaacggtat ggcaagatgc accagaaggt attcacactg cacttgatgt aattcataga
     4141 ttaaaagacg tttatacaaa atctttagct tatgaatttt ctcatataca agatagtgaa
     4201 gaacgcgcgt ggttgcatca aatggtggaa tcaaattcat tgcgtcaacc actatcaaat
     4261 aaaaaacgaa ctgctctttt aaaacgttta acagctgttg aaggtttcga gcaattcttg
     4321 cataaaacat tcgttgggca aaaacgtttc tctatcgagg gcgttgatat gcttgtacct
     4381 gttttagatg aaattgttct agaaggtgct aagaacggcg tagaggatgt catgattggt
     4441 atggctcacc gcggtcgcct aagcgtactt gctcacgtat tagaaaaacc atatagccac
     4501 atgtttgctg agttcaaaca tgcaaaaata gaaggcgcag tggctaattc tggctggact
     4561 ggcgacgtga aataccattt aggtagagaa caagtcgtta gtaacgaaga agttagtact
     4621 cgcgttacat tagcaaataa cccgagtcat cttgagttcg tgaatcctgt agtagaaggt
     4681 ttcgcacgtg cggctcaaga gaatcgtaaa aaatctggtc ttccagatca agatacttca
     4741 aaatcattcg taattttagt tcatggtgat gctgcattcc ctggtcaagg tattgtgtct
     4801 gagacactca acttaagcag attgaacgcg taccaaacag gcggaacgat tcatgttatc
     4861 gcaaacaatg cagttggttt tacgactgat agctatgatt ctcgttctac gaaatattca
     4921 agtgaccttg caaaaggttt cgatattccg attgttcacg tgaatgctga tgatccggaa
     4981 gcttgtcttg cagctgctaa ccttgcgatt caatatcgca tgttgttcaa aaaagacttc
     5041 ttaatcgatt taattggtta ccgccgctac ggtcataacg aaatggatga cccggcagtt
     5101 acgcaaccac aagtgtacaa aaaaattaaa aaccatccaa ctgtaagagc aatttatgca
     5161 gatcaattac aagctgctgg tgttctaaat gcagatgagg ttgaaacaat tacacagttt
     5221 atacaagagc aattaaaatc cgactatgca caagtaccac cagctgatac gagtgatgca
     5281 acaattcacg ttaaagtgcc agatgttgtt gcaaaaggta ttcagtcaat tgatactggc
     5341 gttgagattg actcacttcg tgcaattaat gaaggtctac tatcttggcc agaaggcttt
     5401 aacgtatatc cgaaagtgaa gaaaattctt gagcgccgta aagatgctct tgaagagaac
     5461 ggcaaaattg aatgggcact tgctgaatca ttagcattcg cttctatttt acaagaaggt
     5521 acgccaattc gtttaactgg tcaagattca cagcgtggta cattcgcaca ccgtcatatc
     5581 gtattacacg atactgatac aaatgaaaca tattcaccat tacatcgctt accaaacatt
     5641 aatgcttcat tctctgttca taacagtccg ttatcagagg ctgctgttgt tggttacgaa
     5701 tatggttata acgtattcgc tccagaaact cttgttatgt gggaagcgca atatggtgac
     5761 ttctcaaata ctgcgcaagc attatttgat caatatgttt cagctggaag agcaaaatgg
     5821 ggtcaaaaat ctggtttagt tcttctatta ccacacggtt atgaaggtca aggaccagag
     5881 cactctagtg cacgtccaga gcgtttctta cagttagctg ctgagaataa ctggacagtt
     5941 gcaaacttaa caagcgcggc acaatacttc catatcctgc gtcgtcaagc atctatctta
     6001 ggaacagaag ctgttcgacc attagtactg atgacgccga agagtttatt acgtcaccca
     6061 cttacgcttt caactgctag tcagttaagc gaaggacgat tccaacctgc tttagaacaa
     6121 gaaaaccttg gtatgaaacc aaataaagta aaacgtcttg ttttaagtac aggtaaaatg
     6181 gcgattgact tagcagcaga aatcgagtct ggtaaacatg agtacaactt agacgaagtt
     6241 catgtcgttc gtattgagca attgtaccca ttccctgctg agaaagttca atctattatt
     6301 aaacgcttta aaaacttaga agaaatcatt tgggttcaag aagaacctcg taatatgggt
     6361 gcatggcatt acatggctcc aattctgttc gaacttgctg gagataaagt gaaaacaggt
     6421 tacattggac gtcctgatcg ctctagtcca tctggaggcg atccattcgc tcacaaagct
     6481 gagcaagaac taattgttgc acatgcttta gatgtgaagt ataacttccg tcaagataaa
     6541 caagaaattg aagtttacag caactaaaaa gtaacaatga aggtttctag cttgttcctt
     6601 gggcagaata tctgcccaag gccaggctaa caaatggaga ttaccgaaga caaaagaaga
     6661 aaaaacacac cgttaggcaa ataaggggag gacatttaaa atgatcgaaa ttaaagtacc
     6721 tgagcttgca gaatctatta ccgaaggaac tatttcacaa tggcttatca acgtaggcga
     6781 caaagttgag aaaggtggca gcgttgttga gcttgaaact gataaagtca atgtagaaat
     6841 cattgcagaa gattcaggta ttgtatcgaa gttactaggc gaacctgggg atacagttga
     6901 agttggcgca actatcgcaa ttttagatgc taatggagca ccagttgcag taagtacacc
     6961 tgctccagct gctgagcaac caaaacaaga aacagctgaa gcaccgaaag ctgcggctcc
     7021 aaatgctgaa caaactacgg gtctacaagg cttaccaaat acgaaccgtc ctatcgcatc
     7081 accagctgct agaaaaatgg ctcgtgaatt aggaatcgac ttaaacgacg tacgtagcac
     7141 agatccactt ggacgcgtga gaccacatga tgtacaagct catgctgcag caccaaaaga
     7201 agcaccagct gctccaaaga gcccagctcc tgctccagtt gcaaaaactg aattcgaaaa
     7261 accagttgag cgcgtgaaaa tgtcccgccg ccgtcaaaca attgcaaaac gtcttgtaga
     7321 agttcaacaa acatctgcaa tgttaacaac atttaacgaa gttgatatga gtgcgatcat
     7381 ggaattacgt aaagaacgca aagatgcttt cgagaaaaaa catgatgtac gtcttggttt
     7441 catgtcattc ttcacaaaag cagttgttgc agcattaaaa caattcccat tattaaatgc
     7501 tgaaattcaa ggtgacgagc ttatcatcaa aaaattctat gatatcggta ttgcagtagc
     7561 agctccagat ggattagttg ttccagttgt acgtgatgct aaccaattaa acttcgctga
     7621 aatcgaaagc gaaattcgta atttaggtat gaaagcacgt gataacaaac tttcattaaa
     7681 agaactacaa ggtggtacat ttacaattac aaacggtggt gtattcggtt ctctaatgtc
     7741 aacaccaatc ctaaacagcc cacaagtagg tattttagga atgcataaaa tccaagtacg
     7801 cccagttgca attgataacg agcgtatgga aaaccgccca atgatgtaca ttgctttatc
     7861 ttacgatcac cgtattgttg atggtaaaga agcagttagc ttccttgttg ctgttaaaga
     7921 tatgcttgaa gatccaaaat cattattatt agaaggttga tagattttca acctattaaa
     7981 ggctgtagaa tgaatcattc tacagccttt ttttattgtg ttcatacggg acaaatttca
     8041 tgacataaag tattaatgta tgcctaaacg taaggaggat taaaatgaat aaccttccaa
     8101 ttcatgcaaa acttaaagta aataaggata ctttcttcct ccccgattca aacgggggtg
     8161 tctattttcg aaataacgcc agttcatttc gcatggacgg tgatggaatt tatgactgga
     8221 ttgaaaaatt aatgccaatg tttaacggta attattcttt agcagaaata actgagggtc
     8281 tccctctccc ctatcaaaat cgtgtatttg aaattggaga ggttttatat gaaaatggtt
     8341 tcgttcgcga tgcaaatcaa gatgcacctc atgaattaaa cagttcatta ctcgacagat
     8401 atgcttcaca aattgaattt ttagaagctg attctcattc aggtgcttta aaatttgaaa
     8461 cgtaccgcgg agcaaatgtc cttgtacttg gctccggaga tatgcttact tctttagttt
     8521 cttctttatt agaatctggt ttacctacat ttcattacct cgttacagat cgggatgaaa
     8581 caaactatga cagaatacat gagctaatag aacgtgcata tgaagttgat aacaatgtac
     8641 tccttcaaga aatcgatact acaattgacc gtcccttgca tgaagtattc gaaccttttg
     8701 attggatttt atatgtttct caaaacggag acattgacgg tttaaaaaca gttcacacta
     8761 tttgtagaga aacgaaaaag aatttcatac cagctatttg tttatcaaca ctcggtatag
     8821 ctggacctgt cgtaacagaa aatcgtgatg aatgctggga atccgcatgg catcggctac
     8881 atgaaacgac tttgcaaaat gaaaattcat cggattcctt ctcaccaatt acatctgcaa
     8941 tgttaacaaa tgtaatcgtt tttgaattgt ttaaacatgt cgcggatgat tcatatcgtg
     9001 aaaaagaatc acaattcttt ttattaaact atgaaacact tgaaggaacg tggcatcctt
     9061 ttataaaaca ccctcttgca gctgatgaaa gttttacaat tgatacgata gaaaatcttt
     9121 ctgaaaaact tgagcatcgg tccaaccaac atacttcaac tgatgtattc cgattttttg
     9181 actcattaac ttctaaagaa gccggtatat tccatgtatg ggatgaacaa gattcatatc
     9241 aattaccgtt atcacagtgc tatattcaag tagccactcc actatcagat ggcccagctc
     9301 cccttctgcc tcttatgact cgcagtggat tgactcataa tgaagcacgc cgagaagctg
     9361 gtttaacagg aattgaaaca tatgtagcag aaatcattca ccgccttatt cctgaacata
     9421 atgatatcgg tatcggtgct ggagaaacga tgacagaagg attttaccgg gcactacaac
     9481 aacatttaaa taataaattg tatgagcggc agtcacatat gctagaagaa cttacaacga
     9541 ttgatttaac tgatattcac gataaacatt gtagatttta ttacgatgcc ctcgctacaa
     9601 ttcatgaaac acctaaaatc gcaatgagtg aagagattct cagttttcca gtcgtttggg
     9661 ttggtataaa tgatagatgg tacggtgcat ctaatattaa tatgacgtta gcgttacgaa
     9721 acgcactaca actatcactc tttcacattc aaaatgaaga aattccttac agagctaata
     9781 ttttgtatga ctcatctatt attttatatg acactgattc tcttagagtg gaaatacaac
     9841 cagaagaaga aattccaagc gtacaatctt tacaactcgc cttacaacat ttagaagaac
     9901 ataattttta tcctttcgtg tttgatttag caatcgaacc ctttttgaaa gaaaacttag
     9961 acggtgtgta tggggtatta attgcaaagg aggacggttt atgattcaaa atatattgct
    10021 tataggagat ggccttcttg cagactatgt acatgatcaa ttatgcaaac aatattccat
    10081 cattcgtcag cataccctta cagaagaact tcctgaaaat attcatcttg ctctcgtatt
    10141 acatgatgga tctccttcta ctattcatca tgatgctgag ctaatttttc ggtcaaatca
    10201 tattccgtgg ctacgtggtt ttacttcatt tggcgaaggt attatcggtc cttacattca
    10261 tcctcttacg cccggatgtt cccattgttc tgatggacgc cgttttatcg ctggctttga
    10321 tcaaaaagaa atgtgggaac tacagcggaa atatgccttt aaagcagata atgtaacgag
    10381 gcgtgatgta cgtgccaccc aaaatggaat gttacaaatg tgccatctta tttgcgcaga
    10441 gacagaaaaa atattaactc ataaccattc ttctttagaa aatgaactta ttttactaaa
    10501 tttacaaaca ttacaatgta cgcggcattc ttttcttcca gatcctctct gtcctgtatg
    10561 tagtaattta cctgatgata ctgcggatgc ggcggaagtt tctttacaac cgagtttaaa
    10621 agtaagcacc gaaacgtatc gctgccgttc cattcatgaa ttaaacacat ttttaacgaa
    10681 agactattta gattatcgga tcggtatgtt gaacggcaaa atgcagcatt ctttattgcc
    10741 atttgctgac gtcattataa atatgccatt aatgtttgga aatgaaggtg ttgcaggccg
    10801 aactcattca tttgcagtga gtgaagcaac tgctatttta gaaggtttag agcgatattg
    10861 cggtatgtca cctcgcggga aaaagacaaa tgtgcatggt agttttcatg atttagagga
    10921 acatgcacta aatcccctca cactcggtgt acatacaaat gaacattaca atcgtgataa
    10981 ttttccattt aagccgtttg atcctgatta tgagcaaaac tgggtatggg gatattcttt
    11041 atcacaaaac agaccgcttt tagttcctga atcaattgct tattatagcc tcggtcatcg
    11101 agatgctttc gtgtatgaaa catcaaatgg atgtgcaatt ggcggtagtt tagaagaagc
    11161 gatttttcac ggcattttag aaattgtaga gcgtgatgcc ttcttactca cttggtatgc
    11221 cgaattacct cttccccgcc ttgatctgag ttcagcaaat gatacagaat tacaattaat
    11281 gattcagcgg ttacgtacga ttaccggata tgaattacac gcttttaatg cgacgatgga
    11341 acacggcatc ccgagcttat gggtaattgc aaaaaataca cgtgaaaatg gaatgaacgt
    11401 tgtttgtgcg ggaggcgctc atttagatcc tattcgagct ttaaaaagtg ccattcaaga
    11461 aatcgcaggc atgttactta taacagacga tgaactcgag cacaaaagag aatactatga
    11521 aaaatgctta caagatcctt atttcgttaa taaaatggaa gaccacagta tgctgtacgg
    11581 attgaaagaa acggaagaac gtcttcactt ccttttacga gaagatgcac cagtgcaaac
    11641 gttccaagaa atgaatgtat cacagtcatt tgatatggat ttaacatccg atctccacca
    11701 acttttaaat cgtttgcatc aatctaatct tgaaataatc gttgtagatc aaaccgttcc
    11761 ccttatagaa aagaacggac tacactgtgt aaaagtcatt attccaggca tgttaccgat
    11821 gacattcggc catcacctta ctcgtgttac aggattagat agagtctata ccgtaccgat
    11881 gacacttgga tatagcactg aaccgttaac aaatgaacaa ttaaatccac atccgcaccc
    11941 gtttccatag taaaggaggg atttcatgca gctagatact tttttacatc atctccattt
    12001 ctctattgat gaaattatgc cgaatcatga ggtggactgg aaagacgcac cgcttcctta
    12061 taaattatat cgaaatgtac ctaccatccc gctctcctta gaaatcccgt tatctttatc
    12121 gaactcttct actacaccta ctctaaatga gattggtcac tacctttggt attcatttgg
    12181 tgtaacacaa ttatgtcagc taaatagcga gagaaatgta ttacgcagat ccattccttc
    12241 aggcggtgct ttatatccga atgaattgta tatctattta aagattgacg attatccaga
    12301 tggcatttac cattatgacg ccgcgcatca ccgacttatt ttacttcgcg aaggaaattt
    12361 cgattcttat ttagcagacg cactcggtaa tcgctgtaat atacatgatt gtttcggtgc
    12421 cgcattcgta tccactatgt tttggaaaaa cttctttaaa tacaataact tttcatatcg
    12481 ccttcaagga ttagatagcg gggttctcat tgggcaatta ctagaatgtg caaaacagtt
    12541 cggttatacg aacggcgtat actttcaatt tctagatcgt gcactgaacc atttactcgg
    12601 attgtcagaa ggtgaagaaa gtgtgtatgc cgttattcct ttaggtacag agccagaaac
    12661 taattggttt cacaatgatt accgtgaaaa taaaacagtt acttctcatg agttgttgca
    12721 acaaattccg ccgttagcac atgaacattt cgttcgctca aaacatgtaa atgaacatcc
    12781 gatgataaca aaaataaatg aagcttctat gattgaatcg acagaacact tccaaacact
    12841 acatcatgaa gagcactatc aacataatac gtacgctgta cagctaccga aagtagaacg
    12901 gttatcgtat gatttcctac aactttgtaa aaaacgatat tctcctgatg cggactttat
    12961 tttaaggaaa tgggatgcag ctgagctcgc tactttacta caagaagcga gcctctcctt
    13021 cccctattac agcgaccttg atggtaagta tgtaaatgaa aatgcacgcg tctcattata
    13081 tggatgtttc tataacgtaa aagatataga aaacggtgct tacacttata acaggaaaac
    13141 acattccata caaccaattc ggtatgggga tcttcgttat ctccttcaat ctagtatgac
    13201 gatggataac gtaaaccttt ttcaagtacc actttgctta catgtagtcg gaaagaaaga
    13261 ttactataca aatgcattag gctatagagg ataccgtatt caccaaatgg aagctggtat
    13321 cctcgttcat aaactcgttt ttgctgcaac tgctatgggg atgggcgggc atcctttact
    13381 aagttttgat acaaattcat gtgatcaatt gtacggaatt gatgctggga atgaaacgtc
    13441 tcttattcaa gttccagttg gggcgtatcg ggcgcggaat tggttaaaag gggctttgca
    13501 taattagaag cacgccggta gacggcgtgc tttttttaaa ggacttaatt tataaaaagc
    13561 gaaatgagta tatattctta cataaaagga gaatgtaact tgaacatttt acaacgatta
    13621 attcagcaag caaaaaaccc tcgcgggaca attggttctt ccatgctttg tattatgaac
    13681 gctgcacata tgagactaac aaattgggga ttacaaaaaa tacatatacg taaagatgca
    13741 attactttag atattggttg tggcggcggc aaaacaatac atactctttc aaaacgaatt
    13801 ccatttggga aaatatatgg aattgattat tcagatcaag ctgttgaaaa ctcaaagaaa
    13861 gccaatatac aggacgtaaa aaaaggaaaa gtaatcattc atcaggcaag tgtctcctct
    13921 attccttaca atacaaactt cttcgatctc ataaccgctt ttcaaacaca ctacttttgg
    13981 cccgatgtgg aacaagatat aaaagaaata tttcgcgtct tacaaccgaa tggatctttt
    14041 ttattagtag ctgaaacttt caaaattcaa tatcatatgg agaaatggaa aacgaatgaa
    14101 gaattaataa acctatttta taaaacagga tttacaagtg tgaaatgcta tgaagaagga
    14161 ggttgccttt gtgtaatagg aattaagtaa aaagcagacc ctttgaggtc tgctttttac
    14221 tagattaact taaaaatact cttaatttgt ctagcaaata accaattttt cgtaccgtag
    14281 ttatcattta aactatctaa attgatagat tgtccgttag caaactttaa ttctaacgtt
    14341 gtatttttgt catttgtttt taaattatta tttgtaatgt catcatactt taatttttca
    14401 atctcaatat attcgtcttt ttcttttcca atcacgacat ggtcttggaa gaagaaaaat
    14461 acttctactt ttttaccgaa acaaaataca tttttcgtat aaattaatgt cgcgttatca
    14521 agtccgacac atacttcttt catttcttcc acaacgtgtc caaagtcttc ttcatgtctt
    14581 gtatttgatt caacaatcca ttcttcgatt gttttcatat taattgccat actgcgcccc
    14641 ctggttcgtt cattgcttcg tttaaaaaat aaatactata tgaaaatata agcgattagt
    14701 aatatgtttt caagggggaa cggtatattc aaaataaagt gaaactttaa tcaatagggg
    14761 tcttcatccc cactgattat tagttgaacc aatcgggctt ttacgggcag ttgatcaccc
    14821 acctaacttc tttgctttcg ctggattttg agatgggggt cttactgccc gcaaatagcg
    14881 ggataaagtt aaatttcaaa gtaatatata aggaacacca attccattaa aatttaaacg
    14941 tttgaacgag acattcttca tcatcaatta gctgcgctct ctcatcaaat tcaatgttta
    15001 gttctttata tactttcttc caaaacgaca ctgctggtac attttttaga agttcgataa
    15061 cgaaatattg tcctcttttc tcttctagta aattctcaac agcttgttta ccgattcctt
    15121 ttcctttata ttgattcaat atgaaaatat cattaatacc aaaatcattt tccttcttca
    15181 aaaacggacg ttccagtagt aataagaatc ctacaatact atgatcaact tttataaaat
    15241 acggcgtgat tccgtcattt ttccaaaata tatgcaaatc ttcgtattca aaaaatccgt
    15301 tcgctccgat agttatattc atagtgaact tagaaaggtc atgaagatat aaagcgtaca
    15361 aattacgtaa tatttctttt tctgattctt gaactttttg aagtgctaca atcataaaaa
    15421 aactcccctt cctcatatgt aactatttcc cgatcctctt cattcgacaa aaatgataat
    15481 tcccctttaa caaaaaaata gcactttaaa aagtgctatt ctgctctcct tgccgcttgc
    15541 tgaattggat cccaaacgct gttatatggt ggtgcgtaac ttaagtcaac gtcttctaaa
    15601 tcatgaatgc tcattttatt gaaaagcgcc atcgcgatca catcaatacg tttatctacg
    15661 ccttcttctc caattacttg cccgcccaat aattgtttcg tatcggagcg atatagtaat
    15721 ttcaagtaaa gtggttttgc atttggataa tagcccgcca tatttgtaga atctactttg
    15781 accgttttat acggaatgtg tagccctttt gcttcttttt catttaagcc tgttcttgcg
    15841 agtgtcaaat ccataaattt aataatgcct gtgcctaacg tacctttaaa agctcttcgt
    15901 ttatcaagca tattcagtcc agcaagtcgc ccttgtttat tggctgtcgt tccgagcggg
    15961 atatgatcat gaatttcctt tataacgtgg taatgtgttg cgcaatcacc ggctgcatat
    16021 acgtcttgca catttgtttg catatatgca tttatttcga ttgctccttt atgattctta
    16081 cgtatatttg tcccttcaag aaaatcagta tttggcttca ctccaaccga cactaaaaca
    16141 agatctgctt tatacgtacc tttatccgtt tcgattgctt ctactcgttc atttccttta
    16201 aatgctttta cattttcatt cgttaaaatt tcaatattgt gtttatctgc ttctttatgt
    16261 atatattcag ccatatctgc atcataaatc gtaccgatat gatcatttcg ctcaatcatt
    16321 cttactttct taccaagttc gacgaatgtt tctgccatct ccagtccaat cgcaccgccg
    16381 ccaataatgg ttacatcttc aactttattc gtttctaacg tttttaatat gcgctcagca
    16441 tccggaattg tttttaaaag atgaacgcct tgtaattccc ttccttccca ttctggcata
    16501 acaggacgta ctccagtcgc aattaataat cgatcatatg gaaattcaaa gacatccttc
    16561 gtcttcgtat gctctgcgta caccattttc ttttccgtat ctactttcgt tacttcatga
    16621 cgcactttcg catcaattcc atatttctca cgaaacgtct ttacgttgcg cgcgattaac
    16681 ttttcagttg aagcgatagc accactaatg acatacggta atccacactg agcgtatgaa
    16741 taaatttcac ctttttctaa agttacaaca tttgcatttt catcgtttct aacaatttgc
    16801 atagctgcac tcataccagc tgcatctccg ccaataatga catagttcac tttaccactc
    16861 cttctttttt acatactctt tacgttttcc atattttata gaaataacac ctacttccat
    16921 tgtaaagaaa gagaatttca tcttcaaatt tggtgcacaa acttatgtat gaataggtaa
    16981 ctgtcgtgtc ttataaacaa catgtttaat atgctataac agtaaccaat tgaaagtagg
    17041 tgaaatatac atgtgcgctg gtcttctcgc tcagtttcca gaggaaccga aagaaccaaa
    17101 acccgccttg tcgcttgatc aagaattttc tattaacgca accatttata gtgctcgtgc
    17161 ttggttatct aatgatgaaa cttttccaca aacgatttgg aaaggctctc actttgcttc
    17221 agcatcacac gctggcaagt ccatcttacc aatcggtact gtaaaaattt tgaacttatc
    17281 tgatgataca ataacagtta ctgcatcatc agaatcagat gatactctca aaatagtcgt
    17341 accccctcat tctgaaggtg ttttaacatc taacgcatta tctgacgtgc aagcaagtac
    17401 atcaggagga gcaagtaaag tcacattcct ctttcatatc tttttctcaa gggatcctgg
    17461 ttcagataaa aaaccataaa aaaggtacag ttatgcactg tacctttttc catgtgttct
    17521 attctcttga tttaatcagt tcaatattat aagtttcgat atctgttaac gttcctgtaa
    17581 aataagggtt ttctctatac caagactgtt ttgcaaaata cgcttgcata tatttcattt
    17641 ctagcaattt ttaactgctc tttcgataaa tatgttaaat ctgcgctcgt taattttcga
    17701 atatcactat caggaaagat gaaaccatta tatacatacc cagtcgtagg tggcgggata
    17761 acattataaa caactgtttt ttctgtactt ttcttttgga atggaagatt ataagacgaa
    17821 agtgccgtta ccgtctctac ttgtgtcgtt tctcgtccgc tttctccatt tcgttctaaa
    17881 taaatcgtcg cacttccatc agtcgctact ggcccccatg taatttcttc tcctatcagc
    17941 gctgtaaccg gtttttgatt tacgtacaat gttgcaccag gcgcgttcgt ttgaactgta
    18001 atatattgac cttgcaacgt taaatctatc gttacgttat tttggctttg tttcataagt
    18061 acaacctttt cctcacgcga tagttttaca taatcatttt tatattctga ttgaaacact
    18121 tgattgcctg gaagaaacgg cccatattgc ttctcaaact ttttgtcatc tgtcttatca
    18181 atttcttttc cgttcatttt taacgctacg cctttttcat ttgtaagcaa agttgtatag
    18241 tacgtcttcg ctttcaattt ataccgatca aatataaaga aatactttcc gtctttcgtt
    18301 aatgaaaaat cagctctttc tattccgtcc cgttgttttt caccttgtct caaatattct
    18361 tttaattcat ttacgtaaga tggattttct tttatatatg aaaatagagg cgttacactc
    18421 tctctcgtta tcataaccga tggatcatct gccgtaacga tctcagctaa tttctctccg
    18481 tcccgctctt gtaaaatcgt aatcatccgg tctacttgtg ccacctgcgt ataatacgat
    18541 gatccgtaca aatacaatcc aataatcgct ataacaaata gtgctaacag tgtaatgcca
    18601 acttttgtac cactgctcat gttcttcttt actacaggac ttcccctctt catcccgcag
    18661 ttttgacaaa attgtacacc atcttcaaac tgaactccgc actttgtaca tacattcatt
    18721 cagtcaacca ccttttcatt agaagccagt tattccctgt gttaaggctt gaattatcgt
    18781 gctaatgtaa gaccaaagta caatgaacgt tgcaattcca attaaaacat ttgcaataat
    18841 aagtgtgtaa acgagatcta atccgccatt gtctagtttt aatacggcta cagttatact
    18901 aatccctata taagttgcaa ctaccgataa taatatcggt aagaaaaaga ttaataaaaa
    18961 actaaaaaga aaagaaagaa ctaatatgac aatagccggc gtcgctatcg ttccccatat
    19021 accaaatact tcaagaaacg aaaaagatga tttcatcatc ttaccactta caaaaataat
    19081 aaatccgaca aataaagtta aaattaataa aaagaaaaag accgttatag attctccaaa
    19141 aaacgtggga gtagatatat ctggtgcaaa tgttctcgta actgctgatg ctgcactcat
    19201 cattctataa aaaatacatg ctcctaaaaa acaaataaga acaagactta caattccatt
    19261 tcgcacttca atagtgccgc ttttcataat cgctgtcggt gcttgtaatg catgtttaaa
    19321 aaattgaaaa tagccgctcg caaaccgctt cgcttgttct accgtttcat ttggacgcgt
    19381 ttccttttct tgtgccgcgc gcgcttgttc ctgcccttct tctttgccac tacttgccac
    19441 tacttcttcc gttaacgaat gtccacaatt cccgcaaaac tttgcctcta ctgcatgttc
    19501 tgtatgacat gacggacatt tcattctctt atccctcctt aagcatatac cttatagggt
    19561 gttacaagtt caatatatga atttgtacat aaaacatgac tacaagaaaa agattctgaa
    19621 atccttcttc cgaaagaaaa tatatgtgct agcaatcttg aaaaaaaatg ctattatgaa
    19681 acagaataaa taatattttt aacagattgg atgaaagaaa atggaattgg taaactcaat
    19741 ttttcaaata ctccttacaa gcgtaatcca attattatct ttaattggcg ttatcattgt
    19801 aattggattt ctattaggct atttagaatc tctcacacgc atgtattggt cgagagcttt
    19861 tggaagaaaa ggattcctat taacggcttg gatcggtgtt ccgattcacg aacttggaca
    19921 tgccattatg tgcgtactgt tccgtcataa aattgtggcg actcagttct tcccaacaga
    19981 tacaagtcaa ggggctttag gttatataca acatcaatac aatcaaaaaa gtgtgtatca
    20041 acgaattggg aatttcttta tcggtattgg gcctattatt tctggtatta ctgcattaat
    20101 ccttttaatg cgctatttcg taccagaatc atatttttta tttaatacaa ctctcgaaaa
    20161 aacgattgct tctacttcta ttaatgtaga aatgattcaa aacatgctct tgtcgacgtt
    20221 tgtattattg aaaagcttat ttacaatcgg caatttattg aatccttcct tttggttatt
    20281 tttatttatc gccatttgca tttccgcaca tatcgcttta agtaaaccag acattaaagg
    20341 atcaatagac ggtgttgtcg tcatgtttat cgtgttattt ttattcaaca taatagcagg
    20401 actgtttcaa tacaacagta atcagctaat tggacaggtt atgaaatata atatgtatct
    20461 cattgcgttt tctagtgtgg cactgctgtt ctcttgtctt tctacactcg ttagtttttc
    20521 gttttataaa ataagaagag ggcgttcttt ttgaacgccc tcttcttatt aattattccc
    20581 cttataatca caatgctcaa ccggaacacg agcatgcccc tcttcatcgg tacaccatga
    20641 ctgtgattgg aaggcaagaa agataccaat ccattcttct tccttttcaa agtgaatgag
    20701 tattcctccg tcttgccata taccattatc agctttccat ttctctacat tcccttgatt
    20761 catgtgaata tcatgtatac cgtttcctgg tttgaaatga aaataggaat ctggtgtatt
    20821 ttcttctggt ccccatcttt cgccaaacgc gtaaataatt gctttttctt ccatcgctcg
    20881 ctttatataa cgttctattt tttcgtttaa atcattatct gcacctgctt tttcgggagg
    20941 caaaggaatc atttgttttg agtcaaatag atttcctctt acataatcta aagctacttt
    21001 cggctcatta ttttttactt ccgtaaaacc aaatggtaat gtcggtaaaa tatgaatcgc
    21061 ctctgaccta atattgttac tcgcaaaata taaaacttct gacggataac tttgcgactt
    21121 tacgttaata gcaatacgat aatctactcc agtctcgccc tgtaaatgaa cttgataatg
    21181 aggtgttttc ccttttccaa tctttgattg tataactgta ccttttaaca caccgtagtt
    21241 ttttaggggc atacatttca tctcctattc atttagtaga agctattcat atttaaatca
    21301 ttatccactc ataaaaaaaa tcctcctatt ttaggaggat ttttaatttc tcaacatata
    21361 ccaaacgata acttctacca ttacaagcaa aaccgcacca aagatcatta acgtcgtctt
    21421 ctttaacagt tcattttcac ggtaagggat attacataag taagcaccta gtgtaatccg
    21481 tgacgggcaa gcgattgttg ctactgatga tgcggtgttt tgcagtgttg tgacgtattg
    21541 ccacgggagt gctacgtttt gtgcggtttg catttgtagt tttataaaca ttgcatttga
    21601 tcctgcgtta ctacctgtta aaaatccacc aatagcacca ataaacggag caacgaaaac
    21661 gaaaaaggtt ccaaatgttt caccagctgt ctttgcgagt aataaatgca tgcctgatgc
    21721 acccattaat tctgaaatgg cgataaacat tgtcgtagta atagcaaaag gaatccattg
    21781 tttgattgtt tgcgagagtg attgtttaat aatattagac gggatgcgga agaaaataat
    21841 agtaaataag caagtcatac cgagccaaaa tcctggtgaa tatagtaact ctagtttgta
    21901 agagtatgat ttcaaatcaa gaaccgcata tgatctgaac aaatcatgta atgctggaac
    21961 gaggcgagaa agtaaaatac aaactgttag aaatatataa gggctaataa tttttataat
    22021 ggatacttct ctctccgttg cagcggcatg ttctgttata agattttgcc cactttttcc
    22081 ttttaattta atgataagaa agccaaatgt aatcgtaacg atagaactta atatccctgc
    22141 tagttcaaca cttacgtacg cattagaaag atagattccg agagaaaata atagaaagaa
    22201 tcctacccct tctttccact tttctataac cgcttgccag ccgccaacaa cgtgtaaaga
    22261 aagaataaca aagtaagcaa acatcggaat acttaatagc gctgtatttg taccaagtgt
    22321 tgtaagaggc atatttatta gctgcgaacc gataatcgta ccagttgcca ttgcgcccca
    22381 tgaactagct agtaagccga tgaatgagag cagtacagct tgaaatggtt tatatcctag
    22441 tgaaagaaaa ataggtgctg caaccatgaa gccgataccg aatccactta ctgattcaat
    22501 aagcgggcaa atgccaaaac acataagcag catttgtaat aagcgatcct gagtaacttc
    22561 ttctagaaaa cgtgctactt gatcgatgta ccccattttg ttcatgaggt gaaataaaaa
    22621 aataccgaaa aataaaacgt acccgacaat aaaacaaatt aaccatcctt taatcgttgc
    22681 gtgtacagtt tcacttatcc ctaattgaaa cgttggcgag agtaaaacga ttccaacaga
    22741 cacagcataa gaaattaacg aagaccttaa tgacgtttgt ttaaataaaa ataaacaaat
    22801 gaaaatcatc ataattggga taagtgccaa caatatggcc atattatcat ctcatttcgt
    22861 ttaaaataca atttttaact attatataac agatgttgta attttcaatt gtttttaaaa
    22921 cagatttaaa aaaggagcca aacggcccct tttcattcac tcccattttc tattatcctg
    22981 aaaaactgtc tgctgtccga ttattttttt caacacaaca aacacaatgt aagtacatat
    23041 tgcttgcaat gcaatattcc aaaatttcat taatgtaaat gaatgaatcc gtagaaataa
    23101 ttcgtttaat aatacaatcg aaacgatact aaataattct atactaatcg aaaatagaca
    23161 tatttctaaa atagactgtt cttgaatgcg atttaagttg gaaaagataa atacatatcc
    23221 taaaaataga gccatcaact ctattttcgt catgctaatg agccaagcgt atagcggtac
    23281 agttaaaaga agatatagta gtttacgtct tagcatgcct tctcaccctc taaattatat
    23341 gtattttctg tatattttaa catttattac gcaaaacaaa aagaagagac tacgcctctt
    23401 ctttttgttt tgttgcatat attaattcac atatttcttc tcgtttttca ttttctaaaa
    23461 gctcaatgat cttacttcca acgacaactc cgtcgcatat tgtaacc
//
