LOCUS       NZ_CP022685            21113 bp    DNA     linear   CON 17-JAN-2024
DEFINITION  Streptomyces formicae strain KY5 chromosome, complete genome.
ACCESSION   NZ_CP022685
VERSION     NZ_CP022685.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces formicae
  ORGANISM  Streptomyces formicae
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9611874)
  AUTHORS   Holmes,N.A., Devine,R., Qin,Z., Seipke,R.F., Wilkinson,B. and
            Hutchings,M.I.
  TITLE     Complete Genome Sequence of Streptomyces formicae KY5, the
            formicamycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9611874)
  AUTHORS   Holmes,N.A., Devine,R., Qin,Z., Seipke,R.F., Wilkinson,B. and
            Hutchings,M.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2017) School of Biological Sciences, University of
            East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, United
            Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.0; Newbler v. 2.3
            Assembly Name                     :: KY5 Genome
            Expected Final Version            :: yes
            Genome Coverage                   :: 56.0x
            Sequencing Technology             :: PacBio; 454; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/17/2024 10:10:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,274
            CDSs (total)                      :: 8,185
            Genes (coding)                    :: 8,082
            CDSs (with protein)               :: 8,082
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 39 of 103
            Pseudo Genes (incomplete)         :: 77 of 103
            Pseudo Genes (internal stop)      :: 11 of 103
            Pseudo Genes (multiple problems)  :: 22 of 103
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:13:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6171289
            Orig. end                         :: 6192402
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022685.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Matthew Hutchings,
            University of East Anglia, UK.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21113
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="27"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21113
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21113
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11113](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11113
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(186..201)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.86"
                     /tool="antismash"
     gene            complement(209..1534)
                     /gene="aroA"
                     /locus_tag="KY5_RS27110"
                     /old_locus_tag="KY5_5338c"
     CDS             complement(209..1534)
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645398.1"
                     /locus_tag="KY5_RS27110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5338c"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_098244677.1"
                     /transl_table=11
                     /translation="MTETPAHTALWPAPHASGAVTATVHVPGSKSVTNRALVLAAIAAE
                     PGWLRRPLRSRDTLLMAGALRAMGVGIEEGVGPDGSGEAWRVIPSGLQGPATVDVGNAG
                     TVMRFLPPVAALADGPIRFDGDPRSYERPLTGVIDALRVLGARIDDTTLGSPGALPLTV
                     HGGGALEGGRVEIDASSSSQFVSALLLSGPRFNQGVEVRHVGGPLPSMPHIRMTVDMLR
                     AVGAQVDTPESGGEPNVWRVTPGALLGRDLTVEPDLSNAQPFLAAALVTGGTVTIPDWP
                     AHTTQPGDALRRIFTEMGGSCELTEQGLVFTGSGSVHGIDVDLSEVGELTPGIAAVAAL
                     ADSPSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRRLHGGIFHTYDD
                     HRMATAGAIIGLAVRGVEIENVATTAKTLPDFPDLWTGMLGN"
     gene            complement(1567..2289)
                     /locus_tag="KY5_RS27115"
                     /old_locus_tag="KY5_5339c"
     CDS             complement(1567..2289)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005480455.1"
                     /locus_tag="KY5_RS27115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5339c"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_098244678.1"
                     /transl_table=11
                     /translation="MESTANASPAALWDRLFGTQAAPEQWLVIAAGVVALAVVVPHGVW
                     RVARNAITIAHEGGHGLIALLTGRRLDGIRLHSDTSGLTVSRGKPTGIGMILTAAAGYT
                     APPLLGLGGAALLASGRITAFLWIATALLIAMLVMIRNAYGALTVVVAGGTFLVISWLA
                     STDVQAAFAYAVVWFLLLGGVRPAFELQSKRRRGGAGDSDADQLSRLTHVPAGMWLFLF
                     HAVSLCSLMGGGRWLLDV"
     gene            2339..3193
                     /locus_tag="KY5_RS27120"
                     /old_locus_tag="KY5_5340"
     CDS             2339..3193
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="KY5_RS27120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5340"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_098244679.1"
                     /transl_table=11
                     /translation="MCGRYASSRRPEDLAGIFEIEKWEPEESLAPDFNVAPTKEVYAVL
                     DRPVKDAADPRPVRQLRTLKWGLVPSWAKTPEGGARMINARAETVHEKPSYRRAFASRR
                     CVLPADGYYEWVTAPDERQLEVEGKKKRPRKQPYFVTPADGSVFAMAGLYEFWRDKTLP
                     DEHPSPSSRLRSSRGGPTAWWVTCTVITTEAETTPLADTPEEGPRSLADIHPRMPLMLT
                     PDRWDAWLDPSRTDADDLRTLLEPPPHGLLRAYPVSTAVSNVRNNGPELLTELAGPEEG
                     TLF"
     gene            3195..3836
                     /locus_tag="KY5_RS27125"
                     /old_locus_tag="KY5_5341"
     CDS             3195..3836
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824678.1"
                     /locus_tag="KY5_RS27125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5341"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_098244680.1"
                     /transl_table=11
                     /translation="MTKSEIVETDAGEARITWHPAPGKSARLLLAVSHGAGGGIEARDL
                     KAIAAELPAHGVSVALVEQPWRVAGKKVAPAPKTLDVGWRGIWPALEKKGLPVISGGRS
                     AGARVACRTATELGAAAVLALSFPLHPPGKPEKSRADELLGAGVPTLVVQGGNDPFGKP
                     AEFPEGPYELVEVPHGDHGFAVPKRAEITQDEAVKGITDAVARWAGMLAG"
     gene            4068..4751
                     /locus_tag="KY5_RS27130"
                     /old_locus_tag="KY5_5342"
     CDS             4068..4751
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="KY5_RS27130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5342"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_199843262.1"
                     /transl_table=11
                     /translation="MGPVTGTDAGAEHGQAEQPREGSERSETAAERTARFERDALTFLD
                     QMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRKK
                     QREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKTALQSIPEEFRIAV
                     YLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARDRGLVPAGAGESNGT
                     KGSGS"
     gene            4748..5056
                     /gene="rsrA"
                     /locus_tag="KY5_RS27135"
                     /old_locus_tag="KY5_5343"
     CDS             4748..5056
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014154163.1"
                     /locus_tag="KY5_RS27135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5343"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_098244682.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEVLDHLYEFLDHEMPDSDCTKFETHFEECSPCL
                     EKYGLEQAVKKLVKRCCGQDDVPVDLRAKVMGRIDLIRSGQTVPENDVTQDVAAGEA"
     gene            5240..6586
                     /locus_tag="KY5_RS27140"
                     /old_locus_tag="KY5_5344"
     CDS             5240..6586
                     /EC_number="3.1.4.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018535169.1"
                     /locus_tag="KY5_RS27140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5344"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_098244683.1"
                     /transl_table=11
                     /translation="MRSVPAWARVYILCVALTGAACAVPALGARTPWPAVALLAVLYAG
                     CEQITRCRFVGRRAPRGLGTFFPVLLAGVFLLPPSAAALVAVPGALLARVERHPRWVRR
                     LWRAAQLAVAAWVSARVFEALGGPGACAAPDFPYVLAPAGATVLAFSAVLAALDGGVAV
                     TAERVPARLAWRGLFPRALAPVAVHGLAGLMMAVLWTSPYGPAAGLLVLLPMGVSCWVF
                     AQYHRERAAHQATIRALVQAVDLKDKYTRGHSERVGRASVLIARELGMGDDRVEVLRFA
                     GILHDVGKLGVPTRLLRKEGPLTPEERRVIELHPEYGHEMVRGIGFLGDARAAILHHHE
                     RIDGSGYPYGLAGAQIPESARVVAVADAFDAMTSTRSYRRARPVPVALEELTRCAGAQF
                     DPAMVGALARALERYGWHPEVTSDVPGQAGPVPPAPTVSAPAVPGSAPR"
     gene            6583..7827
                     /locus_tag="KY5_RS27145"
                     /old_locus_tag="KY5_5345"
     CDS             6583..7827
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824676.1"
                     /locus_tag="KY5_RS27145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5345"
                     /product="HD domain-containing protein"
                     /protein_id="WP_234362878.1"
                     /transl_table=11
                     /translation="MSSRLPTAATALAGLLAVLSLAWTLWHGVTEGRTAFAFGVLVALG
                     ELARWGSVRDREPAPLGAAGALAYALLGENAGQPTHHGAPQVIAVVVAAALVGAVPHVA
                     LGKGPSPDHMARRVLTVGFAAVCFQPLYNSGKLKEWVGHGPSFALVMVALLVLTALCDA
                     VLAATTAHARTGWPFGPLLRDELRAMLGIGSAVCATGAVMALAVAVAGLWALPVFSIPL
                     LLTQLSFRRYAAVRATYRQTIASLARATEIAGYTPQGHARRVAGLSRAVGRDLGLSEPD
                     LIVLEHAALMHDIGQLSLVDPVPAGATAALPETEQRRIALLGGAVVRQTGVDSAVAVVV
                     ERQADPYRDQPLTARIVRTANAYDEMARGEGPTGSLDGPLQALERLRLATGRDYQAEVV
                     ESLARVLSRAGNGRA"
     gene            7986..8966
                     /locus_tag="KY5_RS27150"
                     /old_locus_tag="KY5_5346"
     CDS             7986..8966
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="KY5_RS27150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5346"
                     /product="hypothetical protein"
                     /protein_id="WP_055551119.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRSAGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLKVPGGVAASGEPTGMDLGSAAVRLSPEGEAEVVWGRRLDPARIELLSIPL
                     PSSGRRWGEVVLHDGVPHGERTTAAGHSYPVFDEIELWAPSPVPTWVVLLEAATEADRD
                     ALEQLASDAGFAAEDWSSSVRLLCRMCSESRMPSDEGDGEHLDPHDHSEPGHPGPLGHR
                     SPGAVWVPERECGIAAPAGLVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            9048..9698
                     /gene="def"
                     /locus_tag="KY5_RS27155"
                     /old_locus_tag="KY5_5347"
     CDS             9048..9698
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105564.1"
                     /locus_tag="KY5_RS27155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5347"
                     /product="peptide deformylase"
                     /protein_id="WP_098244685.1"
                     /transl_table=11
                     /translation="MAQDTEQQTSGGVLPVDDEGFVIDTEDCEERETAYRERGTSRPIT
                     VVGNPVLHKECKDVTAFDDDLAKLIDDMFATQRVAQGVGVAANQVGVDLKVFVYDCMDD
                     EGVRHVGVVCNPVLQELPAERRSLDDSGEGCLSVPTAYAPLARPDYAEVTGQDEKGNPI
                     KVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKDALRQMEEGTPRYPVVPND"
     gene            10001..11113
                     /gene="cyc1"
                     /locus_tag="KY5_RS27160"
                     /old_locus_tag="KY5_5348"
     CDS             10001..11113
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009190552.1"
                     /locus_tag="KY5_RS27160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5348"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_098244686.1"
                     /sec_met_domain="T1TS (E-value: 2.2e-62, bitscore: 210.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAYSGSTSQTQPPTQTVSVPPALAVPVIEAAFPRRLHPYWPKLQ
                     EKSRTWLREMRLMPPDKVERYADSLCYTDLVAGYYIGAPDELLTAIADLSSWFFAWDDR
                     HDRDSVHGRTAQWRWLCRGLHGTLNEPRTYLHHGDPLVAGFADCVLRLYSFLGPSWNAR
                     FARHFHPVIDAYDEEFRNRRAGTVPTVEAYVELRRLTFAHWAWIDLLEPTARRELPRPV
                     RKHPAYRRAALATQDFSAWYNDLCSLPKELAGDELHNLGISLIHHEGMTLEQAVAEVHR
                     RVTRCVTEFMAAEEEVHSFAAQLADGTVEGRKLADTVESCVFNMRNWFSSVYWFHHESG
                     RYRVDSWDDRSIPPYVTEGIVAENELVGEE"
     gene            11110..12486
                     /locus_tag="KY5_RS27165"
                     /old_locus_tag="KY5_5349"
     CDS             11110..12486
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950763.1"
                     /locus_tag="KY5_RS27165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5349"
                     /product="cytochrome P450"
                     /protein_id="WP_098244687.1"
                     /sec_met_domain="p450 (E-value: 1.8e-74, bitscore: 250.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVESAITAPAASGQGPLRTPPLVGGGAPLLGHAWNLVRDPLGFL
                     AALRDHGDLVRIRLGPKTAYAVCDPELVGALLKNPEYIVGGPLWDTLEVLLGKGVATSN
                     GRLHRRQRRMMQPAFRPERIADYAEVMEEEARATAARWQPGSTVDVSAEMFRTAVRVVS
                     RSLLEVDSIGEKADRISESLHTVFEGLYRRMVLSVGPLYRVPTPANRRFERALADLHAL
                     VDEIVAERRAAGPGGPDDLLAELLRATDESGAPITDQEIHDHVVSLVVAGAENVASTLA
                     WAFHLLTEHPEQERRLVEEVNSVTQGRAITFADLGELPHLRNVVTEAMRIRPAAWIFTR
                     RSVAETELGGYRIPADADIVYSVYAMQRDPRSFERHLEFDPDRWNPERASEVPEFAMMP
                     FSVGNRKCPGDHFSLAELALILGTVIPKWRLTPVGETDTGTKIGITLHPKRLVLRADPR
                     "
     misc_feature    11197..11199
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12553..13572)
                     /locus_tag="KY5_RS27170"
                     /old_locus_tag="KY5_5350c"
     CDS             complement(12553..13572)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061532.1"
                     /locus_tag="KY5_RS27170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5350c"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_199843634.1"
                     /transl_table=11
                     /translation="MPTTNSEKNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVD
                     LHSDVADLAKLSPGEQHMIGRLVAFFATGDSIVSNNLVLTLYKHINSPEARLYLSRQLF
                     EEAVHVQFYLTLLDTYLPDPEDRAAAFDAVEEIPSIREKAEFCFKWINEVEKLDRLETQ
                     ADRRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFA
                     FDVVDTVRKEEPELFDDALQDQVTDMLKEAVEAELQFARDLCGDGLPGMNTDSMREYLQ
                     CVADQRLQRLGFAPVYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGSVSFDDEF"
     gene            complement(13629..16022)
                     /locus_tag="KY5_RS27175"
                     /old_locus_tag="KY5_5351c"
     CDS             complement(13629..16022)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378224.1"
                     /locus_tag="KY5_RS27175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5351c"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_098244688.1"
                     /transl_table=11
                     /translation="MTIAPAEPASATSTPTAEGTDGPGTALLRTLTDLTADLPDADAGR
                     VAAAALRGRSARADVAELRELATEAAAGLISEDPAYSKLAARLLSIGIREEAATQGVRS
                     FTDSVAVGHREGLIADRTASFVTEHAARLDALVDAALADGADFRFGYFGLRTLHSRYLL
                     RHPITRQVIETPQHFMLRVAAGLAEDDSARALDEVAALYGLMSRLDYLPSSPTLFNSGT
                     RHPQMSSCYLLDSPLDELDSIYDRYHQVARLSKHAGGIGLSYSRIRSRGSLIRGTNGHS
                     NGIVPFLKTLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLN
                     LAHWIPDEFMRRVAADQDWSLFSPADVPELVDLWGEEFDAAYRAAEAAGHAKKTIPARD
                     LYGRMMRTLAQTGNGWMTFKDAANRTANQTAEPGHTVHSSNLCTEILEVTDDGETAVCN
                     LGSVNLGAFVVNGDIDWERLDETVRTAVTFLDRVVDINFYPTEQAGRSNAKWRPVGLGA
                     MGLQDVFFQLKLPFDSPEARALSTRIAERIMLASYEASADLAERNGPLPAWEKTRTARG
                     VLHPDHYGVELTWPERWAALRERIATTGMRNSLLLAIAPTATIASIAGVYECIEPQVSN
                     LFKRETLSGEFLQVNAYLVQELKRLGVWDAQTREALREANGSVQDFSWIPEEVRALYRT
                     AWEIPQRGLIDMAADRTPFLDQAQSLNLFLETPTIGKLSSMYAYAWQRGLKTTYYLRSR
                     PATRIARAAGGSQATAAAPVPQQVTDPDAVACSLENPESCEACQ"
     regulatory      complement(16150..16287)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(16271..16285)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 24.21"
                     /tool="antismash"
     misc_feature    complement(16302..16316)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 26.1"
                     /tool="antismash"
     gene            16363..16602
                     /locus_tag="KY5_RS27180"
                     /old_locus_tag="KY5_5352"
     CDS             16363..16602
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013561.4"
                     /locus_tag="KY5_RS27180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5352"
                     /product="CopG family transcriptional regulator"
                     /protein_id="WP_098244689.1"
                     /transl_table=11
                     /translation="MTPKTISFRPDAETHRELEKLAEARDITASDAIRLAIHEAYVREQ
                     YRRAAAELDGWRNDPAYQAEIAEVREEMNELRAW"
     gene            16592..16906
                     /locus_tag="KY5_RS27185"
                     /old_locus_tag="KY5_5353"
     CDS             16592..16906
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0004521 - RNA endonuclease activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010469146.1"
                     /locus_tag="KY5_RS27185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5353"
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /protein_id="WP_098244690.1"
                     /transl_table=11
                     /translation="MRGDLYRLRSRKGAVGHEQRGARYAVVLQTEALNTSTLIVAPTST
                     SAAPGLLHPKLDMEGTATVVLVEQMTAVDPERLGDFAGRVEPDEWSDIERAVKLVLGLL
                     "
     gene            complement(16970..18595)
                     /locus_tag="KY5_RS27190"
                     /old_locus_tag="KY5_5354c"
     CDS             complement(16970..18595)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674905.1"
                     /locus_tag="KY5_RS27190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5354c"
                     /product="sodium:solute symporter"
                     /protein_id="WP_098244691.1"
                     /transl_table=11
                     /translation="MNDGVNGVALAVFIFFFVAVTVMGFLAARWRKAETESLDEWGLGG
                     RSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGAAGFFAVPYTILVYPLIFTFLPRLWS
                     VSHKHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGVGGGP
                     DTNWFVKDLPLLIAFAVLAAYTYSSGLRAPALIAFVKDGLIYLVIVVAIIYIPIKLGGF
                     DDIFAKAGHAFEQTNPATDKPRGALAPPEAGQWTYATLALGSALALFMYPHSITATLSS
                     KSRDVIRRNTTILPLYSLMLGLLALLGFMAIAAGIKVDNGQLAIPQLFEDMFPDWFTGV
                     AFAAIGIGALVPAAIMSIAAANLFTRNIYKDFLKPDATPEQETKISKLVSLLVKVGALV
                     FVLTMDKTVAINFQLLGGIWILQTMPALVGGLFTRWFHRWALLAGWAVGMVYGTLAAYG
                     VASPTQKHFGGSSDTIPGIGEIGYIGLTAFVLNVIVTVVLTFVLKALKAPDGIDETAPG
                     DYTADAGDPGVATELPKATAGAGH"
     gene            complement(18592..18846)
                     /locus_tag="KY5_RS27195"
                     /old_locus_tag="KY5_5355c"
     CDS             complement(18592..18846)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004925869.1"
                     /locus_tag="KY5_RS27195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5355c"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_098244692.1"
                     /transl_table=11
                     /translation="MSDAPEVSRPVVTPVRVVIALCLVAPFVAMLWVSSYAKVEPTFIG
                     IPFFYWYQMLWVLISTVLTMIAYKLWQRDQRARKEGGRS"
     misc_feature    18841..18851
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    complement(18898..18912)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            complement(18968..19165)
                     /locus_tag="KY5_RS27200"
                     /old_locus_tag="KY5_5356c"
     CDS             complement(18968..19165)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019545111.1"
                     /locus_tag="KY5_RS27200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_5356c"
                     /product="YbdD/YjiX family protein"
                     /protein_id="WP_267894300.1"
                     /transl_table=11
                     /translation="MTWLLRGARWMRWYVRELTDESAYERYVAHVRRDHPAATVPSRRA
                     FERMRTDNQESDPRQGFRCC"
     misc_feature    19280..19293
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     misc_feature    20381..20396
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.31"
                     /tool="antismash"
     misc_feature    20749..20764
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.94"
                     /tool="antismash"
ORIGIN
        1 tcgcgggcct tcatggccat cacgatccgg tcgtcgacca ggacggtgag ccgcccccgg
       61 tcgacggtga ggaccatccc ttcggacgcg tcctcgtgct tgggcctgat gtgggtgcgg
      121 gggcggttgc ccttgcggtt ggggcggacg cggatgtcgt cctcgtcggg gttcttgccg
      181 taacggcgca tggttctcgt tccgcccgtc agttcccgag cattccggtc cagaggtcgg
      241 ggaagtcggg gagggtcttg gccgtcgtcg cgacgttctc gatctccacg ccccgcaccg
      301 ccaggccgat gatcgcgccc gcggtcgcca tgcggtggtc gtcgtaggtg tggaagatgc
      361 cgccgtgcag cctgcggggc cggatgtgca ggccgtccgc ggtctcggtg acgtcgccgc
      421 cgagttcgtt gatctccttg gtgagcgcgg ccaggcggtc cgtctcgtgc aggcgcaggt
      481 gggcgacgcc gcgcagcgtc gagggggagt cggcgagggc cgcgaccgcc gcgatgcccg
      541 gggtgagctc gccgacctcg ctcaggtcca cgtcgatgcc gtgcacggag ccgctcccgg
      601 tgaacaccag gccctgctcg gtcagctcgc aggagccgcc catctccgtg aagatccggc
      661 gcagcgcgtc gccgggctgc gtggtgtgcg cgggccagtc ggggatcgtg accgtgccgc
      721 cggtgaccag ggccgcggcg aggaacggct gggcgttgga caggtcgggc tcgacggtca
      781 ggtcgcggcc gagcagggcg ccgggggtga cccgccacac gttcggctcg ccgcccgact
      841 ccggggtgtc cacctgggcg ccgaccgcgc gcagcatgtc cacggtcatc cggatgtgcg
      901 gcatggacgg cagcggccct cccacgtgcc gcacctccac gccctggttg aagcgcgggc
      961 ccgagagcag cagggcgctg acgaactggg aggaggacga ggcgtcgatc tcgacccggc
     1021 cgccctccag tgcgccgccg ccgtgcacgg tcagcggcag ggcgccgggg ctgccgagcg
     1081 tggtgtcgtc gatccgggcg ccgagcacgc gcagcgcgtc gatcacgccg gtcagcgggc
     1141 gctcgtacga gcgggggtcg ccgtcgaagc ggataggacc gtcggcgagg gcggcgaccg
     1201 ggggcaggaa gcgcatgacc gtacccgcgt tgccgacgtc gaccgtggcg gggccctgga
     1261 gccccgaggg gatcacgcgc caggcctcgc ccgagccgtc ggggcccacg ccctcctcga
     1321 tgccgacgcc catggcgcgc agggcgcccg ccatcagcag ggtgtcgcgc gagcgcagcg
     1381 ggcggcgcag ccagccgggc tcggcggcga tcgcggcgag gacgagcgcg cgattggtga
     1441 ccgatttcga accggggacg tggaccgtcg cggtgacggc tccgcttgcg tgcggggcgg
     1501 gccagagggc ggtgtgcgcc ggagtttcgg tcatgccctc actttagtgg ctggccggga
     1561 gcccgctcag acgtcgagca gccagcgccc gccgcccatc agcgaacaca gcgatacggc
     1621 gtggaagagg aagagccaca ttcccgcggg cacgtgcgtg agccgcgaca gctggtccgc
     1681 gtccgagtcg cccgcgcccc cgcgcctgcg cttggactgc agctcgaagg cgggccgcac
     1741 gccgcccagg agcaggaacc acaccaccgc gtacgcgaag gccgcctgca cgtccgtgct
     1801 ggcgagccag gagatgacca ggaaggtgcc gcccgcgacg acgacggtca gggcgccgta
     1861 cgcgttgcgg atcatcacca gcatcgcgat gagcagcgcg gtggcgatcc acaggaacgc
     1921 cgtgatgcgc cccgaagcga gcagggccgc gccgccgagg ccgagcagcg gcggcgcggt
     1981 gtagcccgcg gcggcggtca ggatcatgcc gatgccggtc ggcttgccgc gcgagacggt
     2041 caggcccgag gtgtcggagt gcagccggat gccgtccagg cggcggccgg tgagcagggc
     2101 gatcagaccg tggccgccct cgtgcgcgat ggtgatggcg ttgcgggcca cgcgccagac
     2161 gccgtgcggg acgacgacgg cgagggcgac gacaccggcc gcgatcacca gccactgctc
     2221 gggcgctgcc tgggtgccga agagccggtc ccagagggcg gccgggctgg cgttggcggt
     2281 gctttccatt gcttggactg ctccctctgg tcgtacgcgg tctggcagtc tggcacgtat
     2341 gtgcggacgg tatgcatcca gtcgtaggcc cgaggacctc gcagggatct tcgagatcga
     2401 gaagtgggag ccggaggagt ccctggcccc cgacttcaac gtggcgccca ccaaagaggt
     2461 ctacgcggtc ctcgaccgtc ctgtgaaaga cgcggcggac ccgcgtccgg ttcgccagct
     2521 gcgcaccctg aagtggggtc tcgtgccgtc ctgggccaag acgcccgagg gcggcgcccg
     2581 gatgatcaac gcgcgcgcgg agaccgtcca cgagaagccg tcctaccgcc gcgccttcgc
     2641 ctcccggcgc tgtgtcctgc ccgccgacgg ctattacgag tgggtgaccg cgcccgacga
     2701 gcggcagctg gaggtcgagg gcaagaagaa gcggccccgc aagcagccct acttcgtgac
     2761 cccggccgac ggctcggtct tcgccatggc agggctgtac gagttctggc gggacaagac
     2821 cctgcccgac gagcaccctt ccccaagctc tcggcttcgc tcgagcaggg gaggccccac
     2881 tgcctggtgg gtgacgtgca cagtgatcac cacggaggcg gagaccacgc cgctcgccga
     2941 cacccccgag gagggcccgc gctcgctcgc cgacatccac ccgcggatgc cgctgatgct
     3001 gaccccggac cgctgggacg cctggctcga cccgtcccgc accgacgccg acgacctgcg
     3061 caccctcctg gagccgccgc cgcacggcct gctgcgcgcc tacccggtct ccaccgccgt
     3121 cagcaacgtc cgcaacaacg gcccggagct gcttacggag ctggcagggc ccgaagaggg
     3181 cacactcttc tgacgtgacc aagagcgaga tcgttgagac cgacgcgggc gaggcgcgga
     3241 tcacctggca cccggccccc gggaagagcg cccgcctgct gctcgccgtc agccacggcg
     3301 cgggcggcgg catcgaggcc cgcgacctga aggccatcgc cgccgagctg cccgcgcacg
     3361 gcgtgagcgt cgccctcgtc gagcagccct ggcgggtggc gggcaagaag gtggcgcccg
     3421 cgccgaagac gctggacgtg gggtggcggg ggatctggcc cgcgctggag aagaagggcc
     3481 tcccggtgat ctccggcggc cgcagcgcgg gcgcccgcgt ggcctgccgc accgcgaccg
     3541 agctcggcgc cgcggccgtg ctcgcgctct ccttcccgct gcacccgccg ggcaagcccg
     3601 agaagtcccg cgccgacgaa ctgctgggcg cgggggtgcc gaccctcgtc gtgcagggcg
     3661 gcaacgaccc cttcgggaag cccgcggaat tcccggaggg accgtacgaa ctggtggagg
     3721 tgccccacgg cgaccacggg ttcgcggtgc ccaagcgggc ggagatcacg caggacgagg
     3781 cagtgaaggg catcacggac gcggtggccc ggtgggcggg aatgttggcc gggtgacctc
     3841 tgttgtgcac agcagacggc agacgccgtc accagctgtt cgtacgagag ggagtccgcc
     3901 gcatgggttc gaccatctgc ccgaaccgct ccacgtcgcc tgacctggag tggacggtgc
     3961 tgagcgcgcc caaaaccaca cctattcggg cggcgcgcgg agcggatcgt cgtctatcct
     4021 ccgattcgag tggggctgct ttcggtctca ccacgtcgtt ggaggaggtg ggtccggtca
     4081 ctgggaccga cgcaggggcc gagcacggcc aggcggagca gccccgagaa gggtcggaga
     4141 ggtccgagac ggccgcggag cgcacggccc gcttcgagcg ggacgcgctg acgttcctcg
     4201 accagatgta ctcggcggcg ctgcgcatga cgcgcaatcc ggcggacgcg gaggacctgg
     4261 tgcaggagac ctacgcgaag gcgtacgcgt cgttccacca gttccgcgag ggcaccaacc
     4321 tcaaggcgtg gctctaccgc atcctcacga acaccttcat caactcgtac cgcaagaagc
     4381 agcgcgagcc ccagcgcagc gccgccgagg agatcgagga ctggcagctg gcgcgtgcgg
     4441 agtcgcacat gtccaccggt ctgcgctccg ccgagtcgca ggcgctcgac cacctgcccg
     4501 actcggacgt gaagaccgca ctgcagtcga tccccgagga attccgcatc gccgtctatc
     4561 tggccgacgt agagggcttt gcctacaagg agatcgcgga cattatgggg acacccatcg
     4621 gtacggtgat gtcccgactg caccgcggcc gtcgccagct gcgcggcatg ctggaggact
     4681 acgcccgtga tcgcgggctc gtcccggcgg gcgccgggga gtcgaacgga acgaaaggct
     4741 cgggctcatg agctgcggag agccgcacga gactgactgc agtgaagtcc tggaccatct
     4801 ctatgagttc ctggaccacg agatgccgga cagtgactgc accaagttcg agacgcactt
     4861 cgaggagtgc tctccgtgcc tggagaagta cggcctcgag caggcggtca agaagctggt
     4921 gaagcgctgc tgcggccagg acgacgtccc cgtcgacctg cgggccaagg tgatggggcg
     4981 catcgacctc atccgctccg ggcagaccgt tccggagaac gacgtcacgc aggacgtggc
     5041 ggcgggcgag gcctgaacca ccgcgccgtc ggcgtgagtt gaccgtacga gggcgggccg
     5101 cgacattttc tgtcgcggcc cgccctcgtt ctccccgttc tcccctccgg tcactcgaac
     5161 gtgctaattc acggccgccg ggctctggcc gcgatgccac cgttctactc tccggagctg
     5221 gaacggtgag gagaactcca tgcggtcggt gccggcgtgg gcccgcgtgt acatcctgtg
     5281 cgtcgccctg acgggcgccg cctgcgccgt gcccgcgctc ggcgcgcgca cgccgtggcc
     5341 cgccgtcgcc ctgctcgcgg tgctctacgc cgggtgcgag cagatcaccc ggtgccgctt
     5401 cgtcggccgc cgtgccccgc gcggtctcgg caccttcttc cccgtgctgc tcgccggggt
     5461 cttcctgctg cctccttcgg ccgccgccct cgtcgccgtg cccggcgcgc tgctcgcccg
     5521 cgtcgagcgg catccccggt gggtgcgcag gctctggcgc gcggcccaac tcgccgtcgc
     5581 cgcctgggtg tcggcccgcg tcttcgaggc gctcggcggt cccggggcct gcgcggcgcc
     5641 cgacttcccc tacgtcctgg ctcccgcggg agccaccgtg ctcgcgttct ccgccgtgct
     5701 cgccgccctg gacggcgggg tcgccgtgac cgccgagcgg gtgcccgcgc gcctggcctg
     5761 gcgggggctc ttcccgcgcg cgctcgcgcc cgtcgcggtg cacggcctcg ccggtctgat
     5821 gatggcggtc ctgtggacca gtccgtacgg ccccgcggcc gggctgctcg tgctgcttcc
     5881 gatgggcgtc tcctgctggg tgttcgcgca gtaccaccgc gagcgcgccg cccaccaggc
     5941 caccatcagg gcgctcgttc aggccgtcga cctcaaggac aagtacaccc gcggccacag
     6001 cgaacgggtc ggccgcgcct cggtgctcat cgccagggaa ctgggcatgg gcgacgaccg
     6061 cgtggaggtg ctccggttcg cgggcatcct gcacgacgtc ggcaaactcg gcgtacccac
     6121 ccggctgttg cgcaaggaag gacccctgac gccggaggag cgccgcgtca tcgagctgca
     6181 tcccgagtac ggacacgaga tggtgcgcgg catcggattc ctgggggacg cgcgggcggc
     6241 gatcctgcac caccacgagc ggatcgacgg gagcggctat ccgtacggcc tcgccggggc
     6301 gcagatcccc gagtccgccc gggtggtggc cgtcgcggac gcgttcgacg cgatgacgtc
     6361 cacgcggtcc taccggcggg cccggcccgt gccggtggcc ttggaggagc tgacccggtg
     6421 cgcgggcgcg cagttcgacc ccgcgatggt cggggcgctg gcgcgggcgc tggagcggta
     6481 cgggtggcat cccgaggtca cctcggacgt ccccggccag gcggggcccg tgccgcccgc
     6541 gccgacggtg tccgcgcccg cggtgcccgg ttcggccccg cggtgagttc ccgcctgccc
     6601 acggcggcga cggcgctcgc cgggctgctc gccgtgctgt cactcgcctg gaccctctgg
     6661 cacggcgtca ccgaggggcg gaccgcgttc gccttcgggg tgctcgtcgc actcggggag
     6721 ctggcccggt gggggagcgt gcgggaccgg gagcccgcgc cgctcggggc cgcgggggcc
     6781 ctggcgtacg ccctgctcgg ggagaacgcg ggacagccca cgcaccacgg cgccccgcag
     6841 gtgatcgccg tggtcgtcgc ggccgcgctg gtgggcgccg tgccgcacgt ggcgctcggc
     6901 aaggggccct cgcccgacca catggcgcgc cgcgtgctga ccgtcgggtt cgccgccgtg
     6961 tgcttccaac ccctgtacaa ctcgggcaag ttgaaggagt gggtcggcca cgggccctcc
     7021 ttcgcgctcg tcatggtcgc gctgctcgtc ctgaccgcgc tctgcgacgc cgtgctcgcc
     7081 gcgaccacgg cgcacgcccg caccggctgg ccgttcggcc cgctcctgag ggacgagctg
     7141 cgggccatgc tcggcatcgg ctccgcggtg tgcgcgaccg gcgcggtgat ggcgctcgcg
     7201 gtggccgtcg cggggctctg ggcgctgccg gtgttcagca tcccgctgct gctcacccag
     7261 ctgtccttcc ggcggtacgc ggccgtgcgc gcgacctacc ggcagaccat cgcgtccctg
     7321 gccagggcga cggagatcgc cggatacacc ccgcaggggc acgcccgcag ggtcgccggg
     7381 ctcagcaggg ccgtggggcg cgacctcggc ctgtccgagc ccgacctcat cgtcctggag
     7441 cacgcggcgc tgatgcacga catcggccag ctctccctgg tcgacccggt ccccgcgggc
     7501 gccaccgcgg cccttcccga gacggaacag cgtcggatag ccctgctcgg cggggccgtg
     7561 gtgcgccaga ccggggtgga ctcggcggtc gccgtcgtcg tggagcgcca ggcggatccg
     7621 taccgcgacc agccgctcac cgcgcgaatt gtgcgtaccg cgaacgcgta cgacgagatg
     7681 gcgcggggag aaggacccac agggtcgctc gacggcccgc tgcaggccct ggaacggctg
     7741 cgcctggcca caggacgcga ctaccaggcc gaagtcgtgg agtccctcgc ccgggtcctt
     7801 tcgcgggcgg ggaacgggcg ggcctgaggc gggccgaggc tgggtaaccc atgggtaatg
     7861 agcggccgtc cgaccgtacg tggttggatg cgaagaagag ggtgcacggg ggcacggacc
     7921 ccgatgccgc gccctcagag gatgtgtctt ccgaaatcgt gacaggcggg aatcaggcgg
     7981 gaatcgtgag gatcttcggc aagggacggc accggccctc cgcctcatgg cggcaggcga
     8041 ccgaccgcgc gttcacgctg atcggcgacg gccggtacga ggacgcgggg gccctgctca
     8101 cgcgcgcggc ggatctggag ccctggctgt ccgagtcctg gttcaatctc gcgctcctgc
     8161 acaagttccg gcacgactgg gagcaggcgc gggccgcggg gctgcgcgcc gtcgcgctcc
     8221 tggaccggtc ggcgggcgcc cccgactggt ggaacgtcgg catcgcggcg accgccctcc
     8281 aggactggcc gctggcccgc cgcgcctggc aggcgtacgg cctgaaggtg cccggcgggg
     8341 tcgcggcgtc cggcgagccg acgggcatgg acctgggcag cgcggccgtg cggctctcgc
     8401 cggagggcga ggcggaggtc gtgtggggcc gcaggctcga cccggcccgc atcgagctcc
     8461 tgtccatccc gctgccctcg tcggggcggc gctggggcga ggtcgtgctg cacgacggcg
     8521 tcccgcacgg cgagcggacg acggcggcgg gccactccta tcccgtcttc gacgagatcg
     8581 agctctgggc gccctcgccc gtgcccacct gggtggtgct cctggaggcc gccaccgagg
     8641 ccgacaggga cgccctggag cagctcgcgt ccgacgcggg ctttgccgcc gaggactggt
     8701 cgtcctcggt gcggctgctc tgccggatgt gctccgagtc ccggatgccg agcgacgagg
     8761 gcgacggcga gcacctggac ccgcacgacc acagcgagcc gggacacccg ggcccgctcg
     8821 gccaccgcag cccgggcgcg gtctgggtgc ccgagcgcga gtgcggcatc gcggcgcccg
     8881 cgggcctggt gcgcggcctg ctcgacggct gggtggcgga cagcccggac tcccgcgact
     8941 ggcgggacct cgaagaggtc tgctgacccg aggaggtccc cgggcacttc gccgtaggct
     9001 gtaccggcac aaactcttga gggcttcaag gaaggcgtac ggcggacatg gcgcaggaca
     9061 ctgagcagca gacctccggc ggggtgctcc ccgtcgacga cgagggcttc gtcatcgaca
     9121 cggaggactg cgaggagcgc gagacggcct accgcgagcg cggcacgtcg cggccgatca
     9181 cggtcgtcgg caatccggtc ctgcacaagg agtgcaagga cgtcaccgcc ttcgacgacg
     9241 acctcgcgaa gctgatcgac gacatgttcg cgacccagcg cgtggcgcag ggcgtgggcg
     9301 tggccgccaa ccaggtcggc gtcgacctga aggtgttcgt ctacgactgc atggacgacg
     9361 agggcgtgcg ccacgtcggc gtggtctgca acccggtcct ccaggagctg cccgccgagc
     9421 ggcgcagcct ggacgactcg ggcgagggct gcctctccgt gccgaccgcc tacgccccgc
     9481 tggcccgccc ggactacgcc gaggtgaccg ggcaggacga gaagggcaac cccatcaagg
     9541 tgcgcggcac gggctacttc gcgcgctgcc tgcagcacga gacggaccac ctgtacggct
     9601 acctgtacat cgaccgtctc tccaagcggg agcgcaagga cgcgctgcgg cagatggaag
     9661 agggcacgcc gcgctacccc gtggtgccga acgactgacg tgcgccacgc ctgaggggcg
     9721 tgggaaccgc gtgacacgag cggcccctgg tcgggaacta ctccctgacc aggggccgtt
     9781 gtcgtgggcc gatcggatgt gcgagcagaa ccggctgccg gtgatccata ttcagtcacg
     9841 taaggggagg ttctcggcac tggggggtag tgaatggcgc aaatctgttc cctgaacggt
     9901 cagttgtggt gctgaatgga aagcgcgggg atacgcaacg gcgcgcgccc ggtacggcgg
     9961 gaggggcgtg cgtccacaag cggctgaaag gggttcgtcc gtgcctgcat attccgggag
    10021 cacttcacag acacagccac ccacacagac ggtatcggtc ccaccggcgc tggccgttcc
    10081 ggtgatcgag gcagcgtttc ctcgccgtct gcatccgtat tggccaaagc ttcaggagaa
    10141 gtccaggacc tggctccgcg aaatgcggct catgcccccg gacaaggtcg agcggtacgc
    10201 ggacagcctc tgctacaccg acctggtggc gggctactac attggcgcgc cggacgagtt
    10261 gctcaccgcg atagcggacc tcagcagctg gttcttcgca tgggacgacc ggcacgacag
    10321 ggactcggtg cacggcagga cggcacagtg gcggtggctg tgccggggcc tgcacgggac
    10381 cctcaacgaa ccgcgcacgt acctgcacca cggggacccg ttggtcgcgg ggttcgccga
    10441 ctgcgtcctg cggctctact cgttcctcgg tcccagctgg aacgccaggt tcgcccggca
    10501 cttccacccg gtgatcgacg cgtacgacga ggagttcagg aaccggcgcg ccggcacggt
    10561 gcccacggtc gaggcgtacg tcgagctgcg ccgcctcacg ttcgcgcact gggcgtggat
    10621 cgatctgctc gaacccaccg cgcgccgcga actgccgcgc cccgtgagga aacaccccgc
    10681 ataccggcgg gcggcccttg cgacccagga cttctcggcc tggtacaacg acctgtgctc
    10741 gctcccgaaa gaactcgcgg gagacgaact gcacaatctc ggaatcagcc tcatccacca
    10801 tgagggaatg acgctcgaac aggccgtggc ggaggtccac aggcgcgtca cgcgatgcgt
    10861 cacggaattc atggcggccg aggaggaagt gcattcattc gccgctcaat tggcggacgg
    10921 aaccgtcgag ggaaggaaac tcgcggacac cgtggaatca tgcgtcttca atatgcggaa
    10981 ctggttctct tccgtctatt ggttccatca cgaatccggc cgctatcgcg tcgacagctg
    11041 ggacgacagg tccatacccc cctacgtcac ggaaggcatc gtggcggaaa acgaactggt
    11101 aggtgaggaa tgagcgtcga atccgcgata accgcccccg ccgcgtcagg acagggcccg
    11161 ctgcgtaccc cgccgctcgt cggcggggga gcgcccttac tcggccacgc ctggaacctg
    11221 gtgcgcgacc cgctaggctt cctcgccgcg ctgcgtgacc acggggatct cgtacggatc
    11281 aggctggggc ccaagacggc gtacgcggtg tgcgatcccg aactggtcgg cgccctcctg
    11341 aagaaccccg agtacatcgt cggagggccg ctctgggaca ccctggaggt gctcctcggc
    11401 aagggcgtgg cgaccagcaa cggccgactg caccggcgtc agcgccgcat gatgcagccc
    11461 gcgttcaggc ccgagcggat cgccgactac gccgaggtga tggaggagga ggcgcgcgcc
    11521 acggccgccc gctggcagcc gggaagcacc gtcgacgtca gtgcggagat gttccgcacg
    11581 gcggtccggg tcgtctcgcg ctcgctcctg gaggtcgact ccatcggtga gaaggcggac
    11641 cgcatcagcg agtcgctgca caccgtcttc gaggggctct accgccggat ggtgctctcg
    11701 gtcgggccgc tctaccgcgt gccgaccccg gccaaccggc gcttcgagcg cgcgctcgcc
    11761 gatctgcacg cgctcgtcga cgagatcgtc gcggagcgcc gtgcggcagg gcccggcggc
    11821 cccgacgacc tgctcgcgga attgctgcgg gccacggacg aatcaggggc ccccataacc
    11881 gatcaggaga tccacgacca cgtggtttcc ctggtcgtcg caggagccga gaatgtggcc
    11941 tcgacactgg cgtgggcgtt ccatctgctg accgaacacc ccgagcagga aaggcggttg
    12001 gttgaagagg taaattccgt cacgcagggg cgggcgatca cattcgcgga cctgggcgag
    12061 ctgccgcacc tccgcaatgt cgtcacggag gccatgcgta tacggcccgc ggcttggata
    12121 ttcacccgca ggtccgtggc cgaaaccgag ctgggcggct atcgcattcc ggcggacgcc
    12181 gacatcgtct acagcgtgta cgcgatgcag cgcgacccgc gttccttcga gcggcacttg
    12241 gagttcgacc cggaccgctg gaatccggaa cgcgcttcgg aggtccccga gttcgcgatg
    12301 atgccgttca gtgtcggcaa ccgaaagtgc cccggcgacc acttcagcct cgctgaactg
    12361 gccctgatcc tgggcacggt gatcccgaaa tggcgcctga caccggtcgg ggagaccgac
    12421 accggaacca agatcggcat cacgctgcac cccaagcggc tcgtcctgcg ggccgacccg
    12481 cgctgaacga gcggtgtgcc caccccgccc cccgtgacgg ggcgggcaca ccggggcccg
    12541 gttgcgccag actcagaatt cgtcgtcgaa ggagaccgaa ccctcgaccg cgacctggta
    12601 cgcggagggc cgccgctcga agaagttggt cagctcctgc acgccctgca actccatgaa
    12661 ggagaagggg ttctccgagc cgtagaccgg cgcgaagccg agccgctgca ggcgctggtc
    12721 ggcgacgcac tgcaggtact cgcgcatcga gtccgtgttc atgccgggca ggccatcgcc
    12781 gcacaggtcg cgggcgaact gcagctcggc ctcgacggcc tccttgagca tgtccgtgac
    12841 ctggtcctgg agcgcgtcgt cgaagagctc gggctcctcc ttgcggacgg tgtcgaccac
    12901 gtcgaaggcg aagctcatgt gcatcgtctc gtcacggaac acccagttgg tgccggtcgc
    12961 gaggccgtgc agcagaccgc ggctgcggaa ccagtagacg tacgcgaagg cgccgtagaa
    13021 gaagaggccc tcgatgcacg cggcgaagca gatgaggttg agcaggaagc ggcggcggtc
    13081 ggcctgcgtc tccaggcggt ccagcttctc gacctcgttg atccacttga agcagaactc
    13141 ggccttctcc cggatcgagg ggatctcctc gaccgcgtcg aaggcggcgg cgcggtcctc
    13201 cgggtcgggc aggtaggtgt cgagcagcgt caggtagaac tggacgtgca cggcctcctc
    13261 gaagagctga cggctcaagt agagccgcgc ctcgggggag ttgatgtgct tgtagagcgt
    13321 cagcaccagg ttgttggaga cgatcgagtc acccgtcgcg aagaacgcga ccaggcggcc
    13381 gatcatgtgc tgctcgcccg gcgagagctt ggcgaggtcg gcgacgtccg agtggaggtc
    13441 gacctcctcg acggtccagg tgttcttgat cgcgtcccgg tagcgctcgt agaagtccgg
    13501 gtagcgcatg ggacgcaggg tcagctcgaa gcccgggtcg agcaggttct tctcggagtt
    13561 ggtggtgggc agggcttccg gcgcggagcg ctgtccatca ggggtggtgg tcgggagacg
    13621 ggtgggcatt actggcaggc ctcgcaggac tcggggtttt ccagggagca ggcgacggcg
    13681 tcggggtcgg tcacctgctg ggggacgggg gccgcggcgg tggcctggga gccgcctgcc
    13741 gcgcgggcga tgcgcgtcgc cgggcgcgag cgcaggtagt acgtggtctt caggccccgc
    13801 tgccaggcgt aggcgtacat cgaggagagc ttgccgatgg tcggcgtctc caggaacagg
    13861 ttcagggact gcgcctggtc gaggaacggg gtgcggtcgg ccgccatgtc gatcagaccg
    13921 cgctgcggga tctcccacgc ggtgcggtac agcgcgcgga cctcctcggg gatccaactg
    13981 aagtcctgca ccgagccgtt ggcctcgcgc agcgcctcac gggtctgcgc gtcccacacg
    14041 ccgagccgct tgagctcctg caccaggtag gcgttgacct ggaggaactc gcccgacagc
    14101 gtctcgcgct tgaagaggtt ggagacctgc ggctcgatgc actcgtacac gcccgcgatg
    14161 gacgcgatgg tggcggtcgg cgcgatggcg aggagcaggg agttgcgcat gccggtcgtg
    14221 gcgatgcgct cccgaagcgc cgcccagcgc tcgggccacg tcagctcgac gccgtagtgg
    14281 tcagggtgca gcacgccgcg cgcggtgcgg gtcttctccc aggcgggcag cgggccgttg
    14341 cgctcggcga ggtccgcgga cgcctcgtac gaagcgagca tgatccgctc ggcgatgcgg
    14401 gtggagaggg cgcgcgcctc gggggagtcg aacggcagct tcagctggaa gaagacgtcc
    14461 tggaggccca tcgcgccgag gcccaccggg cgccacttgg cgttggagcg cccggcctgc
    14521 tcggtcgggt agaagttgat gtcgacgacg cggtcgagga aggtgacggc ggtgcggacg
    14581 gtctcgtcga gccgctccca gtcgatgtcg ccgttcacca cgaaggcgcc gaggttgacc
    14641 gagccgaggt tgcagacggc cgtctccccg tcgtccgtca cctccaggat ctccgtgcag
    14701 aggttggagg agtgcaccgt gtggccgggc tccgccgtct ggttggcggt gcggttggcg
    14761 gcgtccttga aggtcatcca gccgttgccg gtctgcgcga gggtgcgcat catgcggccg
    14821 tacaggtccc gggccgggat ggtcttcttc gcgtgccccg cggcctcggc cgcgcggtag
    14881 gcggcgtcga actcctcgcc ccacaggtcg acgagctcgg gcacgtcggc cggggagaac
    14941 agcgaccagt cctggtcggc ggcgacccgg cgcatgaact cgtcggggat ccagtgcgcg
    15001 aggttgaggt tgtgcgtgcg gcgcgcgtcc tcgccggtgt tgtcgcgcag ctccaggaac
    15061 tcctcgatgt cggagtgcca ggtctccagg tagacggcgg ccgcgccctt gcggcgcccg
    15121 ccctggttca cggcggcgac cgaggcgtcg agggtcttca ggaacggcac gatgccgttg
    15181 gagtgcccgt tcgtaccgcg gatcagcgaa ccccgcgagc ggatgcggga gtacgagagt
    15241 ccgatcccgc ccgcgtgctt ggagagccgc gcgacctggt ggtagcggtc gtagatcgag
    15301 tcgagctcgt cgagcgggga gtccaggagg tagcaggagg acatctgcgg gtgccgggtg
    15361 cccgagttga acagcgtcgg cgaggacggc aggtagtcca ggcggctcat caggccgtac
    15421 agcgcggcga cctcgtcgag cgcgcgggcg ctgtcgtctt cggcgagacc ggccgccacg
    15481 cgcagcatga agtgctgcgg ggtctcgatg acctgccgcg tgatggggtg gcgcaggagg
    15541 tagcggctgt gcagggtgcg caggccgaag tagccgaagc ggaagtccgc gccgtccgcg
    15601 agcgcggcgt ccaccagggc gtcgagccgg gccgcgtgct cggtgacgaa ggacgccgtg
    15661 cggtcggcga tcagaccctc gcggtgcccg acggcgacgg agtcggtgaa ggagcgcacg
    15721 ccctgcgtgg ccgcctcctc gcggatgccg atcgacagga gcctggcggc gagcttggag
    15781 tacgccgggt cctcggagat gagccccgcg gccgcctcgg tcgccagttc ccgcagctcg
    15841 gccacgtcgg ccctggccga cctgccgcgc agcgcggcgg ccgcgacccg gcccgcgtcg
    15901 gcgtcgggca ggtcggcggt gaggtcggtc agggtgcgca gcagcgcggt ccctggcccg
    15961 tcggtaccct cggcggtcgg cgtggacgtc gctgacgcag gttcggcagg cgcgatggtc
    16021 acgtggagct ctccctcgct cggctctggg ccaggggagg gaatggtgca cgggcgcacc
    16081 cggacagggc ggcgtaccgc gtccaccggc ccactccacg aggcccggac ggtcggcacc
    16141 cgggccggac gactcgggtg cgctgccggc aggtcctcgg acttgcgggt acgacaaaga
    16201 cgtacacata caccgttgcg ggacagttcc ggacttgcac cggattcccc tgcgacgaca
    16261 gcgagcacga gcatacatct tgtgccgggt ttctgaagca ggcccacatc ttgtgtcacc
    16321 gatgggagtt gcgtgtaatg cggggcgtat tacaataggg tcatgacgcc gaagaccatc
    16381 agtttccgcc cggacgccga gacgcatcgc gagctggaga agctggccga ggcgcgcgac
    16441 atcacggcgt ccgacgccat aaggctcgcc attcacgagg cgtacgtgcg ggagcagtac
    16501 cgacgggccg ccgcggagct cgacggctgg cgcaacgacc ccgcgtacca ggcggagatc
    16561 gccgaagtcc gggaagagat gaacgaactc cgtgcgtggt gacctctacc ggctgcgctc
    16621 ccgcaagggt gcggtggggc acgagcagcg cggtgcccgg tacgccgtcg tgctgcagac
    16681 cgaagcgctc aacacgtcca cgctgatcgt cgcgccgacg tcgaccagcg cggctccggg
    16741 cttgctgcac cccaagctgg acatggaggg caccgcgacc gtggtgctcg tcgagcagat
    16801 gaccgcagtg gacccggagc gcctcggtga cttcgccggg cgggtcgagc cggacgagtg
    16861 gagcgacatc gagcgtgccg tgaagctggt gctcgggctt ctctgacgcg ggtacgacga
    16921 cgggccgccg gacactccgg cggcccgtca cgcgtacgcg gcggaagact cagtggcccg
    16981 cgcccgccgt cgccttcggc agctccgtgg cgacgccggg gtcaccggcg tccgccgtgt
    17041 agtccccggg cgcggtctcg tcgatgccgt cgggggcctt cagcgctttc aggacgaagg
    17101 tgaggaccac ggtcacgatc acgttcagga cgaacgcggt gaggccgatg tagccgatct
    17161 cgccgatgcc cgggatcgtg tcggacgagc cgccgaagtg cttctgcgtc ggcgaggcga
    17221 cgccgtacgc cgcgagcgtg ccgtagacca tgccgaccgc ccagcccgcg agcagcgccc
    17281 agcggtggaa ccagcgggtg aacaggccgc cgaccagcgc gggcatcgtc tgcaggatcc
    17341 agatgccgcc gagcagctgg aagttgatcg cgacggtctt gtccatggtc aggacgaaga
    17401 ccagcgcgcc caccttcacc aggagcgaga ccagcttgga gatcttggtc tcctgctcgg
    17461 gcgtcgcgtc gggcttgagg aagtccttgt agatgttcct ggtgaagagg ttcgccgccg
    17521 cgatggacat gatggcggcg gggacgagcg cgccgatgcc gatcgcggcg aaggcgacgc
    17581 cggtgaacca gtcggggaac atgtcctcga agagctgcgg gatcgcgagc tgtccgttgt
    17641 cgaccttgat cccggccgcg atcgccatga agccgaggag cgcgagcagc cccagcatca
    17701 gcgagtacag cggcaggatc gtggtgttgc ggcggatcac gtcgcggctc ttggaggaga
    17761 gcgtcgccgt gatcgagtgc ggatacatga acagcgcgag ggccgagccg agcgccagcg
    17821 tcgcgtaggt ccactggccc gcctcgggcg gtgcgagcgc gccgcgcggc ttgtcggtcg
    17881 ccgggttggt ctgctcgaag gcgtgaccgg ccttggcgaa gatgtcgtcg aagccgccga
    17941 gcttgatcgg gatgtagatg atggcgacga cgatgacgag gtagatcagg ccgtccttca
    18001 cgaacgcgat cagcgcgggg gcgcgcagac ccgaggagta cgtgtaggcg gcgagcaccg
    18061 cgaaggcgat gagcagcggc aggtccttga cgaaccagtt ggtgtccggg ccgccgccga
    18121 cgcccatcac gtcgagcacg gcctggatgc cgaccagttg cagcgcgatg tacggcatcg
    18181 tggcgaggat gccggtgacc gcgacggcca gcgagagccc cttggagccg aaccggccgc
    18241 ggacgaagtc cgacgtggtc acgtacccgt gcttgtgcga gaccgaccac aggcgcggca
    18301 ggaaggtgaa gatcagcggg tagacgagga tcgtgtacgg gacggcgaag aagccggccg
    18361 cgcccgccgc gtagatcgcc gcggggacgg ccacgaaggt gtacgccgtg tacaggtcgc
    18421 cgccgagcag gaaccaggtg acccaggtgc cgaacgaccg tccgcccagg ccccattcgt
    18481 ccaggctctc ggtctcggcc ttgcgccagc gggcggcgag gaagcccatc accgtgacgg
    18541 cgacgaagaa gaagatgaac acggcgagcg cgacgccgtt gactccgtcg ttcatgaccg
    18601 cccgccttcc ttgcgggcgc gctggtcacg ctgccacagc ttgtacgcga tcatcgtcag
    18661 gaccgtggag atgagcaccc acagcatctg gtaccagtag aagaacggga tgccgatgaa
    18721 ggtcggttcg accttggcgt aggaactgac ccagagcatc gccacgaacg gcgcgacgag
    18781 gcagagggcg atgaccacgc ggaccggcgt gaccaccggt ctgctcactt caggcgcatc
    18841 tgacatgtca cggctccgct ccctcgctca tcccacgttt gacgtgcggg aaatctaagc
    18901 gagagtcttg atctacggaa cccccgtccg gataacggac gggtcaccag tgcgtcaacg
    18961 tgcctgttca gcagcagcgg aagccttgcc gggggtccga ctcctggttg tctgtccgca
    19021 tacgctcaaa agcgcggcgg ctggggacag ttgcggccgg atggtccctg cggacatgag
    19081 ccacgtaccg ttcgtacgcc gactcgtcgg tcagctcgcg gacgtaccac cgcatccagc
    19141 gcgcgccgcg cagcagccac gtcacggaat cagctcccgc ttctcctcgc gcgtcgcgat
    19201 caggcccgcg ggggccgtca acttcgactc cacgtacggc gcttcgctca gccgcgagga
    19261 ggcggggtcg cggacgtgct tgacgcagat ccgggccgcg tcggcgatca cgatgacgat
    19321 gagcagggcg agggcggccg aaaggacgcc gtccaccgtg gagttggtga ccacggtgtg
    19381 catgtcgtcc atggtcttgg cgggcggcag gaccttcccc gcgtcgatcg cgtcctggta
    19441 gttggagcgc tgctggaaga agccgacgcg cggatcgctg gagaacacct tctgccagct
    19501 cgcggtgagc gtgaccgtcg cgtcccagac cagcggaatc ccggtgatcc aggcccactt
    19561 gaggcgcccg gacttcacga gcagcgtcgt gcagacggcg agcgccacgg ccgcgagcag
    19621 ctggttggcg atgccgaaga tcgggaagag ctggttgatc ccgccgagcg gctcgtgcac
    19681 gccgacccag aggaagtacc cccacaggcc ggtgaccgcg gcgctggtga ggacgagccc
    19741 ggggcgccaa ctcacgttcc tgaagggctt gtagacgttg ccgagcatgt cctggagcat
    19801 gaagcggccc acgcgcgtgc ccgcgtcgag cgcggtgagg atgaacagcg cctcgaacat
    19861 gatcgcgaag tggtaccaga aggcccgcat cgagccgccc gtgaccttcg agaagatctc
    19921 ggagacgccg atcgcgaggg tgggcgcgcc gcccgtgcgc gagagcagcg aggactcctc
    19981 gacgttcttg gcggcctgcg ccagatcggc cggtgagatg gagtacccga agcccgcgac
    20041 ggccttcgac gcctcctgga cggtgtcgcc gatgacgccc gcgggcgcgt tcatcgcgaa
    20101 gtagagaccg gggtcgatga tcgacgcggc gacgagcgcc atgatcgcga cggccgactc
    20161 catcagcatg gagccgtagc cgatcatcct gacctgcgtc tccttctgga tcatcttcgg
    20221 cgtcgtaccc gaggagatca gcgcgtggaa gcccgagagg gcgccgcagg cgatggtgat
    20281 gaagacgaag gggaagagcg atccggcgaa gaccgggccg tcgccgcgcg aggcgaagtc
    20341 ggtgaccggg tccatcttca gcgtcggcag ggcgatcacc acgccgagcg cgagcagcac
    20401 gatggtgccg atcttcatga acgtggagag gtagtcgcgc ggcgcgagca gcatccacac
    20461 cggcaggatc gaggcgatga agccgtacgc caccagccag atgaccagcg tcgagggcgc
    20521 gagcgtgaac gtgtcggcga gcgaggactc ggcgacccag cgcccggaga ccagcgcgag
    20581 cagcagcagg gcgatgccga tgagggagac ctcactgacc cggcccggac gcagtacgcg
    20641 caggtagaag cccatgagca gggcgatcgg gatggtcatc gcgatggaga aggtgcccca
    20701 cggcgactgg gcgagcgcgt tgacgatgac gagcgcgagc accccgagca ggatgatcat
    20761 gatcgcgaag gtggcgagca gcgccgcggc cccgccgaac gggccgatct cctcgcgggc
    20821 catctgcccg agcgacttgc cgtcgcgccg ggtggagaag aacagcacga ccatgtcctg
    20881 cacggcgccc gcgaagatca cgccgacgat gatccagatg gtgcccggca ggtaccccat
    20941 ctgcgcggcg agcacgggcc ccacaagggg gcccgcgccc gcgatcgcgg cgaagtggtg
    21001 accgaggagg acccggcggt cggtcgggtg gaagtcgatg ccgttgtcga gccgctcggc
    21061 gggcgtcgcc cgcgacttgt cgaccttgag gaccttgtac gcgatgaact tgg
//
