LOCUS       NZ_CP022685            23241 bp    DNA     linear   CON 17-JAN-2024
DEFINITION  Streptomyces formicae strain KY5 chromosome, complete genome.
ACCESSION   NZ_CP022685
VERSION     NZ_CP022685.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces formicae
  ORGANISM  Streptomyces formicae
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9611874)
  AUTHORS   Holmes,N.A., Devine,R., Qin,Z., Seipke,R.F., Wilkinson,B. and
            Hutchings,M.I.
  TITLE     Complete Genome Sequence of Streptomyces formicae KY5, the
            formicamycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9611874)
  AUTHORS   Holmes,N.A., Devine,R., Qin,Z., Seipke,R.F., Wilkinson,B. and
            Hutchings,M.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2017) School of Biological Sciences, University of
            East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, United
            Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.0; Newbler v. 2.3
            Assembly Name                     :: KY5 Genome
            Expected Final Version            :: yes
            Genome Coverage                   :: 56.0x
            Sequencing Technology             :: PacBio; 454; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/17/2024 10:10:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,274
            CDSs (total)                      :: 8,185
            Genes (coding)                    :: 8,082
            CDSs (with protein)               :: 8,082
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 39 of 103
            Pseudo Genes (incomplete)         :: 77 of 103
            Pseudo Genes (internal stop)      :: 11 of 103
            Pseudo Genes (multiple problems)  :: 22 of 103
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:13:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4812992
            Orig. end                         :: 4836233
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022685.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Matthew Hutchings,
            University of East Anglia, UK.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23241
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="24"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23241
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23241
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13241](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13241)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            476..604
                     /locus_tag="KY5_RS42570"
                     /old_locus_tag="KY5_4072"
     CDS             476..604
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999697.1"
                     /locus_tag="KY5_RS42570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4072"
                     /product="DLW-39 family protein"
                     /protein_id="WP_003999697.1"
                     /transl_table=11
                     /translation="MKKLLLVALAAIGGLLVYRQIQADRAEQDLWTEATDSVPTGS"
     misc_feature    complement(611..628)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.83"
                     /tool="antismash"
     gene            929..2296
                     /locus_tag="KY5_RS20675"
                     /old_locus_tag="KY5_4073"
     CDS             929..2296
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379510.1"
                     /locus_tag="KY5_RS20675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4073"
                     /product="hypothetical protein"
                     /protein_id="WP_199843168.1"
                     /transl_table=11
                     /translation="MVAALSTCVVAGLAGQGVAAGTPSPYAFAEGAEEIDGAASNVEGP
                     LLVAGSTYKSSLPRVGQRFYRLELKAKENAYVSATAVPRLGTKVSYADGLKVSVQDANG
                     YNCSPLDSEKARFGSSESARPITATASRRVGTAEKSCTGAGTYYVLVERISDPETTQEE
                     WDLELRVASEPALRTAGTTKPPETWDSASPQPPTGARKQREGGTSFNKARGLENGVWGD
                     RVEPGETHFYRVPVDWGQSLSVGAELGSSGRGLTEDRGFVSTALVMSLTNPVRAQVDDA
                     DTAYDGKQNVTALGALPPVAYENRFAPERKVSAMRFAGWYYLSVHLNPDVAQKFGRAPL
                     DVTLRISVEGSPRPGPAYAGSAKPADEFSVTERDAEAARRGESDASATSTGGGGGDDRV
                     MVMIAVGGIGTGVGLLTILGVWTLIARRRAAAVALRGASAVPGATSPARFGPPRGW"
     gene            complement(2333..4009)
                     /locus_tag="KY5_RS20680"
                     /old_locus_tag="KY5_4074c"
     CDS             complement(2333..4009)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482989.1"
                     /locus_tag="KY5_RS20680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4074c"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_098243647.1"
                     /sec_met_domain="Pkinase (E-value: 2.2e-38, bitscore:
                     131.0, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEVFAGRYELVDPVGHGGVGAVWRAWDHRRHRYVAAKVLQQSDA
                     HSLLRFVREQALRIDHPHVLAPASWAADDDKVLFTMDLVAGGSLAHVIGDYGPLPPRFA
                     CTLLDQLLSGLAAVHAEGVVHRDIKPANILLEATGAGRPHLRLSDFGISMRKGEPRLTE
                     TDYVVGTPGYFAPEQMMGAEPDFTADLFAVGLVALYLLEGAKPDAKALIEHFAEHGTPR
                     APQGMPEPLWQVIATLLQPDPQSRFRTATGARKALASAAEMLPEPGPDDELVEIFDQLA
                     PLPTGFGPDGPLNSARRRHPAPAPAPGHVPPAPGHAPAPVLPVIPEAPATPPRPMAAPA
                     PIPPSTSHPAAASGPPAAPDRSFTWDPSLTPGQPAAPDPSATTDPPAAADPSIDSPPSV
                     GSGRPASWEPSTASRWDPSTASDTGSFPLPPPQQPTAPPSPSTPPVPRAPVPPAPIPPQ
                     APTPEPTHVTSPDQAHRHAPTYPYTAHAAQVPPPSPPVSDQAIASRTAPSQAVTQPRPA
                     HSRSHSRVRPRRPGPPAKVAVPMLLVALACLTVGFWALAQI"
     gene            complement(4059..4607)
                     /locus_tag="KY5_RS20685"
                     /old_locus_tag="KY5_4075c"
     CDS             complement(4059..4607)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569181.1"
                     /locus_tag="KY5_RS20685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4075c"
                     /product="hypothetical protein"
                     /protein_id="WP_055527494.1"
                     /transl_table=11
                     /translation="MDAAQQDTTARARELQRNWYGEPLGALFRRLIDDLGLNQARLAGV
                     LGLSAPMLSQLMSGQRAKIGNPAVVQRVQLLQELAGQVADGSVSAAEATDRMDEIKKSQ
                     GGSVLTNTAQTATSSGAPTVKRVVREIQSLLRSVAAAGDIIDAADSLAPTHPELAEFLR
                     VYGAGRTADAVAHYEAHQS"
     misc_feature    complement(4669..4682)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.1"
                     /tool="antismash"
     tRNA            4791..4863
                     /anticodon=(pos:4817816..4817818,aa:Ala,seq:tgc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="KY5_RS20690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="KY5_tRNA0045"
                     /product="tRNA-Ala"
     gene            4791..4863
                     /locus_tag="KY5_RS20690"
                     /old_locus_tag="KY5_tRNA0045"
     misc_feature    complement(4920..4936)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.82"
                     /tool="antismash"
     gene            5083..6147
                     /locus_tag="KY5_RS20695"
                     /old_locus_tag="KY5_4076"
     CDS             5083..6147
                     /GO_function="GO:0008171 - O-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013087.4"
                     /locus_tag="KY5_RS20695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4076"
                     /product="methyltransferase"
                     /protein_id="WP_159072564.1"
                     /transl_table=11
                     /translation="MTADASAPIGLPGGPYDPPHVRVLSLAAAKWVSQPIAVLASLGVA
                     DALGDGPRAVEDLAAAVGARPGALGRCLRAAASVGVFAEREDGTYELTPMAGSLRVDAP
                     DSIRNWVLMLNQGPMWDSFGKLEEAVRTGRSAFEVAHGRPLFEHLDKDVEFRGVYESAM
                     GELTSELAGELAPAIDFSGYGTLVDLGGGDGELLGTLLRHCPESRGVLVERPHVVERAR
                     VRLAELGVVDRTRLVAGDATEEVPSGGDAYLIKNMLHCFDDATALAVLRRVREAGGEDA
                     RLFVIEVVVPPGNGFHWAKLIDIEMLADNDGRERGEDEWRELLGRAGFELERVVPATPP
                     QSVLIARPVRRVGG"
     gene            6176..6349
                     /locus_tag="KY5_RS41850"
                     /old_locus_tag="KY5_4077"
     CDS             6176..6349
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KY5_RS41850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KY5_4077"
                     /product="hypothetical protein"
                     /protein_id="WP_157877789.1"
                     /transl_table=11
                     /translation="MRAPWKGDPVERARNRARQRELQRQQDAEQARNRERQEREQAERD
                     ARQARDEQNDRR"
     gene            complement(6392..7102)
                     /locus_tag="KY5_RS20700"
                     /old_locus_tag="KY5_4078c"
     CDS             complement(6392..7102)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014906.4"
                     /locus_tag="KY5_RS20700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4078c"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_098243649.1"
                     /transl_table=11
                     /translation="MGAQRAANTTRRQPRPAITLEAVTDAALRTLQRDGLDALSMRRLA
                     DELSIQAPSLYWYVRNKDELLDLLADALLAELRLDAHVRTDGDWRTELRDMMLEYRAYL
                     LSKRDSGRVLAGRLQLGPHFLRHAEVILGAVRRAGFDDQDTADSLYSLTQYVQGFVLHE
                     TSPLSADVARGADPKKFLEEARERLAGLSPEEYPNVVAVGARLARPDIEARFTYGLDRL
                     LDGLRSRLESRDRD"
     misc_feature    complement(7149..7165)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.19"
                     /tool="antismash"
     gene            complement(7185..8255)
                     /locus_tag="KY5_RS20705"
                     /old_locus_tag="KY5_4079c"
     CDS             complement(7185..8255)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012517.4"
                     /locus_tag="KY5_RS20705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4079c"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_098243650.1"
                     /transl_table=11
                     /translation="MQHGISLLPDCRPATRGAREYYEDVLRISRLADEAGLDYVKMTEH
                     YLKEYGGYCPSPLTFLAAVAAQTSRIRLMTGCVLPAFHHPIQLAAHTAMVDALSGGRLD
                     VGFARAWMPYEFTAFGVSMDESRDRFNHTIAAVLRLWTEEKVSEESPFFSFRDATSLPA
                     PVQRPHPPVWGAAVRSRQSFAWLAEQGFGLLVTPPPRQQDLAGVRDLVEVYLDTFEDVH
                     GSTPDGPRPRVAVSIPLYVAETDDEAYETADPLLREYLTVWAEAAEAWMHTSSKDYPTY
                     SQMALTLRNLDIADFRSLGTAVVGSPATVLERARQLRDFLSVDTFLWQVDFGGQDGATM
                     ERSFRLFRDEVLPQLR"
     gene            complement(8285..9151)
                     /locus_tag="KY5_RS20710"
                     /old_locus_tag="KY5_4080c"
     CDS             complement(8285..9151)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KY5_RS20710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KY5_4080c"
                     /product="hypothetical protein"
                     /protein_id="WP_159072565.1"
                     /transl_table=11
                     /translation="MSGPGPVVAGGLVLVVTCAAYGFLAPWLAGRLRRLAPARARSLAA
                     TAAGALTVAAAIAVDVLPWHPAPPDATLLPLLIVGLALGWGEFAVAVFLTSILADTVDA
                     LRATRPVLAAARRMPRLRPATATATTSARPRAAAGRTHWLSLTRGHVAEEAKARVAGPG
                     VWGVVTLATAVLCDETVFRATLTEALAGAGAAMAVGVAVLAQIAVVVRGMPAGRRRTPE
                     TWAPVVLMATVHTVLYWRGSTLVPLLAADAAFFALLIPTEGKRPFHVKHRLFHVKQRPA
                     ATGAGRR"
     gene            complement(9148..10026)
                     /locus_tag="KY5_RS20715"
                     /old_locus_tag="KY5_4081c"
     CDS             complement(9148..10026)
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014566.4"
                     /locus_tag="KY5_RS20715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4081c"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_098243652.1"
                     /sec_met_domain="Abi (E-value: 3.6e-09, bitscore: 35.8,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSLIHTHELREPALAALTLCALSCLALASHLHVRFFDHRGVHTL
                     QVYAAVLAVVAGCGLLVVGPRVLGSGVGWGLLVSPLLGAAVAPLVATADTLITRRLGRR
                     AARSAARDQGRGANRDGTTRGGRAPATAPRARATRPVGQAARLAGASSATTTRQQWTPS
                     HRDTDVALPLGWLVAVGVLEECVFRGTLTGVALTQHGLAQRVLILLAATGAFALSHIFF
                     GWAQVAAKLPLSVIALALTLATGSALGAVVTHALFNVRIWRYQNTVRGAAPDARDKDRR
                     ASRARGRTVAS"
     gene            complement(10001..11329)
                     /locus_tag="KY5_RS20720"
                     /old_locus_tag="KY5_4082c"
     CDS             complement(10001..11329)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="KY5_RS20720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4082c"
                     /product="YcaO-like family protein"
                     /protein_id="WP_098243653.1"
                     /sec_met_domain="YcaO (E-value: 2e-45, bitscore: 154.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLTLHQDEDTRVHRLRARMHGPLCGITTSMGFLTRYPGGPRLLV
                     GTADMTGVHVRQDQPPPKAGSYHIGGYGIFPFESHIRSLAETLERYSGYAAALDGRFEI
                     HHLSYAELAARGEPVLPRSAFRLFTDEQYAREGFPFDPFDADAPSGWLRVGSLTDGSRC
                     WVPAQRFLLGYVRERDEPWTLPAVTTGTATHTTPQAALRAALEEVVQVDAAMGHWYGRT
                     ESVLIRPDARTRHLDAIVDTYFPASAPRPEFHALPSPDLPGFTIACLLRQPPGLVPEVA
                     IGLGSGASLARAMYRALLEAAGVQWLAAWVAVEQAVQGTPADEDIYDLEGNVGLYATSQ
                     GARTVERRFARHTERAASELPPDDDRPVKEAVRTLVDAFAHSGKQLYFGDLTTRDLRAL
                     GFHAMRVWSPETVSLPLPSAVPAAHPRFADYGGFTDDVPHPYP"
     gene            complement(11329..12381)
                     /locus_tag="KY5_RS20725"
                     /old_locus_tag="KY5_4083c"
     CDS             complement(11329..12381)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03882.1"
                     /locus_tag="KY5_RS20725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4083c"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_098243654.1"
                     /transl_table=11
                     /translation="MTDNRQPTDNGQPRVRRSFSVIGHSPDVVELRTGVWNAKSYTLTD
                     DSRSGTLFNLISGLDGTLSRRDLAKREGVSRVEVEALVDHLYGLDAIEEAPGNALDAYL
                     DDMAALGGRTAEPVATGVVLLGDTDLCELTASLLPAEVTGDVLIPGADHPVRARLDALA
                     PAVLHDGLAFEEAVETLRPWQDSYLLLAERTIDPVRAQLLNRLTRAAGIDWTYAAVDGP
                     FLFVGPTMVAGRSACFECFETRVTMNLRESAGYQRYKAALARSAVLAGAPPVYGPVQSL
                     LCSHLAMEATNYLSCGSTFTVEKVLGCYLPSMEIAYQEVLPLPGCPGCGPVPERDDETL
                     HFDPRTWLEG"
     gene            complement(12429..13241)
                     /locus_tag="KY5_RS20730"
                     /old_locus_tag="KY5_4084c"
     CDS             complement(12429..13241)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="KY5_RS20730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4084c"
                     /product="SagB/ThcOx family dehydrogenase"
                     /protein_id="WP_159072566.1"
                     /sec_met_domain="PF00881 (E-value: 3.3e-18, bitscore: 65.2,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFENLSSGTFRRIAEEFLMATRMRRWDRSALLSIGYYFSDVMAV
                     VQSRQDRVPHRSAPRTPLPEGADIDAGLTETVLRRRSGRDFSGAPVGLDEITSVLRFAG
                     SVTAEADIELADGAPLTMGFRTVPSAGGLYPVEIWLAARNVAGLEPGLHRFLPVEESLA
                     TQAGPEAVTELIASFDPQDGSIDFDRTAAVILLVGNPWRSMRKYGPRGMRSMFHEAGGI
                     AQNAHLAATGLGLESVDFSGFYDDEAHSALGLDGVHRTLLHTVLLGAA"
     misc_feature    13371..13380
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.82"
                     /tool="antismash"
     gene            complement(13431..13574)
                     /locus_tag="KY5_RS41855"
                     /old_locus_tag="KY5_4085c"
     CDS             complement(13431..13574)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KY5_RS41855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KY5_4085c"
                     /product="hypothetical protein"
                     /protein_id="WP_157877791.1"
                     /transl_table=11
                     /translation="MKLQSEKVAEHRNSTPQAALEPFGAGRDEAVLVPGACSCCCGAVV
                     RK"
     misc_feature    13563..13579
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            13854..15086
                     /locus_tag="KY5_RS20735"
                     /old_locus_tag="KY5_4086"
     CDS             13854..15086
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="KY5_RS20735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4086"
                     /product="cytochrome P450"
                     /protein_id="WP_159072567.1"
                     /sec_met_domain="p450 (E-value: 3.1e-21, bitscore: 74.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALDGVPDEAIDLLNPAFMADPGPGYARLHRVDPVTRVRLRPGLN
                     PWLVCGYDEAMEVLSDPLFSVDPASTGDSVRDAIAVGRAEEKTALLGRHLLSVDPPDHT
                     RMRRLMSRALTARRMRALEGPIGDFADALLDKLDARGEPGFDVLGDYALPLAVEVICEL
                     IGIPAADRPRFQEWGALLVRSELQDDAAFDGAADEMAGYFVPLLAARREEPADDLVSAL
                     VTAHGEEQLDDYELISLVYQLFFAGHESSAYLICNAVLRLLRHPDERAALAAEPALVER
                     VIEEVLRVDGPVKVPTWRFPLRDMELGGRKVRAGEPVLILLGAAGRDPKRFPDPDRFDS
                     GRTGRQHLAFSHGIHHCMGAAVGRTEGRVAVGRLFARFPGLELAVPAEGLRWRDNLMMR
                     GVCELPVRVAG"
     gene            complement(15235..16824)
                     /locus_tag="KY5_RS20740"
                     /old_locus_tag="KY5_4087c"
     CDS             complement(15235..16824)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00711.1"
                     /locus_tag="KY5_RS20740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4087c"
                     /product="MFS transporter"
                     /protein_id="WP_098243657.1"
                     /transl_table=11
                     /translation="MAVDAPARQGPSPYRTLPALCVPLALTMLQSTVLSTALPDIQDDL
                     NGGIQDIQWVISGYSLAFAALMLTGGACGDRFGRKKTFLTGLAVFLGGAVFSALAGSVW
                     VLVAAQAVLGVGAALLMPNTLSIIRHVFTDSGERGTAIGIWAAVAGAAVAFGPVVGGPL
                     VENFGWEGIFWMYVPIAVLGFVLAVRMVPESSNPERRLDPAGLVLSVAAMSAIVYATIE
                     GGSRGWSDRLVVGTYLAGGVLLIVFVITELRVREPMLDLSFFRDRVFTGSVIAGFVLYF
                     GLFAITYFLMLWLQTVLGWSAVGAGLAILPGMLLAMVSAPLAGWMTSKVGGAIPLGLGI
                     LFASLTMFGASLYGADARYAEYWWVVLLVGLGIGLTLTPISTLVMMRVPAARSGMASGA
                     SNATRQLGSVFGVAVLGTLLTTRMTDSVRDRLIDAHVPAAAREEVLRGVEAGGAQSAGG
                     GGSARITALVNDGFVDGLHLAERVGGALLLVTAVAVYFLVRGRDRDDIETELTERTGTE
                     GSGSAGQVAGRL"
     gene            complement(17106..17804)
                     /locus_tag="KY5_RS20745"
                     /old_locus_tag="KY5_4088c"
     CDS             complement(17106..17804)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119476.1"
                     /locus_tag="KY5_RS20745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4088c"
                     /product="DUF5324 family protein"
                     /protein_id="WP_098243658.1"
                     /transl_table=11
                     /translation="MTRIDSVRAATGSAKDSVRHAADAVAPYADTAKDRAAHYAHEARV
                     RLAPKVSQAAEQARVQYGAHVAPRVEQARTHVPPKVDHAAHEAAVRTRKAARQAADYSK
                     PRIEHAVAAAQPVRDEAAARGAAALAALRGEVTPKEIRRLARKHERRARAGRLTKRLAV
                     LGILAGGAFAAWKWWDKQANPDWLVEPPAATEVPDTTLTPVDGSAQAVLDPEVQAKQAE
                     AEADAAERDK"
     misc_feature    complement(17762..17776)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    complement(17875..17890)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.5"
                     /tool="antismash"
     gene            18067..18600
                     /locus_tag="KY5_RS20750"
                     /old_locus_tag="KY5_4089"
     CDS             18067..18600
                     /EC_number="5.2.1.8"
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /GO_process="GO:0000413 - protein peptidyl-prolyl
                     isomerization [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569175.1"
                     /locus_tag="KY5_RS20750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4089"
                     /product="peptidylprolyl isomerase"
                     /protein_id="WP_098243659.1"
                     /transl_table=11
                     /translation="MAEQLYATLKTNQGDIEVRLLPNHAPKTVKNFVELAQGEREWVHP
                     ATGKKTSDRLYDGTVFHRVISGFMIQGGDPLGNGTGGPGYEFEDEFHPDLAFDKPYLLA
                     MANAGPGTNGSQFFVTVSPTAWLTRKHTIFGEVANDAGKKVVDAIAATQTNPRTDRPVN
                     DVVIESVVIETRDA"
     gene            18743..19642
                     /locus_tag="KY5_RS20755"
                     /old_locus_tag="KY5_4090"
     CDS             18743..19642
                     /EC_number="3.4.21.105"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013002231.1"
                     /locus_tag="KY5_RS20755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4090"
                     /product="rhomboid family intramembrane serine protease"
                     /protein_id="WP_098243660.1"
                     /transl_table=11
                     /translation="MDQAPGSPQEPQGASALPGCYRHPDRETGISCTRCERPICPECMI
                     SASVGFQCPECVREGSGTGHAPTANQPRTVAGGAVTADPRLLTKALVGINLALFVVQLS
                     VGDSFTDRFDLIGRAFVPELGSVEGVAEGQWYRLVTAMFLHSSYMHIAFNMLSLWWIGG
                     PLEAAFGRARYLALYGASGIAGSALTYLIAEPNQPSLGASGAIFGLFGATAVLMRRLNY
                     DMRPVIALLVINLIITFGPGFNIAWQAHVGGLVGGVVVGYAMVHAPRERRNLIQYGSVA
                     LIVLVSLVMVLVRTGQLT"
     gene            complement(19903..20160)
                     /gene="crgA"
                     /locus_tag="KY5_RS20760"
                     /old_locus_tag="KY5_4091c"
     CDS             complement(19903..20160)
                     /codon_start=1
                     /gene="crgA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569173.1"
                     /locus_tag="KY5_RS20760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4091c"
                     /product="cell division protein CrgA"
                     /protein_id="WP_098243661.1"
                     /transl_table=11
                     /translation="MPKSRIRKKADDYTPPPSKKATNIKLTNRSWVAPVMLAMFLIGLA
                     WIVVFYVTDGKLPIDPLGNWNIVVGFGFIAAGFGVSTQWK"
     misc_feature    20129..20146
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.11"
                     /tool="antismash"
     misc_feature    20165..20179
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            20303..21073
                     /locus_tag="KY5_RS20765"
                     /old_locus_tag="KY5_4092"
     CDS             20303..21073
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975081.1"
                     /locus_tag="KY5_RS20765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4092"
                     /product="DUF881 domain-containing protein"
                     /protein_id="WP_098243662.1"
                     /transl_table=11
                     /translation="MSNSADSHKGAGRRPRWRPVRVLTGAVFALAGLIFFTSFNTAKGT
                     NIRTDASLLKLSDLIQERSHKNGELDESNGSLRDDVESLAQRDNGGTKADDARLKALEE
                     NAGTKKLGGEAVTVTLADAPPNATAKLPGYPEPQPNDLVIHQQDLQAVVNALWQGGAEG
                     IKVMDQRLISTSAVRCVGNTLILQGRVYSPPYKVTAVGDPDKLKNALAASPEIQNYMLY
                     VNAYGLGWKVDDDGAVTLPGYSGTVDLHYAKPVE"
     gene            21129..21848
                     /locus_tag="KY5_RS20770"
                     /old_locus_tag="KY5_4093"
     CDS             21129..21848
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010985758.1"
                     /locus_tag="KY5_RS20770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4093"
                     /product="class E sortase"
                     /protein_id="WP_098247376.1"
                     /transl_table=11
                     /translation="MRVLVRTFSELCVTVGTLIVLFVVYVLFWTGVKADSAMDSQIDAL
                     QDQWARGAVSTGRGGAGEGDDGGGKGADDAAPQKPAPYKDGKAFAVMYVPRFGFTWNKP
                     VLQGTGTDVLKKGLGHYASTAQLGQKGNFSVAGHRRTYGDPFKDFPKLRPNDAVVLTDG
                     ATWFTYRIDKKPYRTLPSDIGVIDPVPRKSGYDGPGRYLTLTTCEPEWGHSHRLIAWAH
                     LDATQPVEAGKPEALRR"
     gene            21903..22064
                     /locus_tag="KY5_RS20775"
                     /old_locus_tag="KY5_4094"
     CDS             21903..22064
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005314870.1"
                     /locus_tag="KY5_RS20775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4094"
                     /product="hypothetical protein"
                     /protein_id="WP_098243663.1"
                     /transl_table=11
                     /translation="MYGWIWRHLPGNAWLRALISLVLVFAVVYVLFQYVFPWAEPLLPF
                     NDVTVDGQ"
     gene            22061..22720
                     /locus_tag="KY5_RS20780"
                     /old_locus_tag="KY5_4095"
     CDS             22061..22720
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249: carbamoyl phosphate synthase small subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483005.1"
                     /locus_tag="KY5_RS20780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_4095"
                     /product="aminodeoxychorismate/anthranilate synthase
                     component II"
                     /protein_id="WP_098243664.1"
                     /transl_table=11
                     /translation="MSAPGGARRSRVLVVDNYDSFVFNLVQYLYQLGAECEVLRNDEVE
                     LKHAQDGFDGVLLSPGPGTPEHAGVCVEMVRHCAATGVPVFGVCLGMQSMAVAYGGVVD
                     RAPELLHGKTSLVRHEGKGVFAGLPSPFTATRYHSLAAEPATVPAELEVTARTEDGIIM
                     GLRHRELAVEGVQFHPESVLTEHGHLMLANWLVECGDTGAVERSSGLAPVVGRATA"
     misc_feature    complement(22892..22906)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
     misc_feature    complement(23108..23123)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.73"
                     /tool="antismash"
ORIGIN
        1 ccgtggccgg tgcgggcgca cacaccgtgg cgttgcgtgc gttcgtggtg tcctgtaccg
       61 ccgtggccgc ggtggccgtc gtggtgagtc ccagcgcggc gaacagcgcg aggaaggcgg
      121 tgacgatcgt ggtccacagc ttcatggcct tggtgccggt catggcccct caattcaggt
      181 tgggcgattt gcgtactttc ctcatgatgt gtatcggggg ccgagagtgg tggaccgacg
      241 cacgcgccgc gtcgatgttc agatgaacac cacccggatg gccccaaggg ccccgagagg
      301 gggcaagagc ggcgaaagtc acaacgggcg ggatccgctg ggagcggcgg catccgtttc
      361 gactgctgcg cggggggcgg tagttggggt ggatccaggt caccgatcga tatcgatcgg
      421 tgtgtatagt cgggcgccag aagtccccta cgtcaaggaa agacgaggtc gcgcggtgaa
      481 gaagcttctc ctggtcgcac tggccgccat cggcgggctc ctcgtgtacc gccagatcca
      541 ggcggatcgc gccgagcagg atctgtggac ggaggcgact gactccgtgc ccacgggttc
      601 gtgagtatcg acaacagtca cttcacaagc cccggtcgct ttgcggccgg ggcttcgtgt
      661 tgcctggacc gaccggatgt gcccgcgata ttcgcttgcg tgaacgagtt gattgcgtaa
      721 gcgaacgtga ggggtggggc gggaccgccg atggcgggta cacggtggtg tttccgcggc
      781 gtcgcgcggg caggacggtc gggatgggtg ggacggctgg gttcacgacg aggggtggcg
      841 cgtgatgggg cggcggctga tcgatggccg ggcggcgcga gggggcgggc gccgggcggc
      901 gcggcggggc aggtgtcggg cggcagccgt ggtcgccgcc ctgtcgacgt gcgtggtggc
      961 ggggcttgcg ggccagggag tcgccgcggg gacgccgagt ccctatgcct tcgccgaggg
     1021 agccgaggag atcgacggtg cggcgagcaa cgtcgaaggg cctctgctcg tggcgggttc
     1081 gacgtacaaa agctccctcc cgcgcgtggg acagcgcttc taccgtcttg agctcaaggc
     1141 caaggagaac gcgtacgtct ccgccaccgc tgttccgagg ctcggtacga aggtctccta
     1201 cgccgacggc ctcaaggtgt ccgtccagga cgccaacggc tacaactgca gccccctgga
     1261 ctcggagaag gcgcggttcg gttcgtcgga gagcgcacgg cccatcacgg cgacggcgtc
     1321 ccggagggtg ggtaccgccg agaagagctg tacgggggcg ggcacttact acgtgctggt
     1381 cgagcggatc agcgatcccg agaccaccca ggaggaatgg gacctggagc tgcgtgtcgc
     1441 ctcggaaccc gccttgcgga cggcggggac gacgaagcct ccggagacat gggattccgc
     1501 ctctccccag ccgccgaccg gcgcccggaa gcagcgtgag ggcggcacga gcttcaacaa
     1561 ggcgcgcggg cttgagaacg gggtctgggg ggaccgcgtg gagcccgggg agacgcattt
     1621 ctaccgggtg ccggtcgact ggggacagag cctctcggtc ggcgccgagc tgggcagttc
     1681 cggcaggggc ctcacggagg accgggggtt cgtctcgacc gcgctggtca tgtcgctgac
     1741 caatccggtg cgggcgcagg tcgacgacgc ggacacggcg tacgacggga agcagaacgt
     1801 cacggccttg ggggcgctgc cgcctgtcgc ctacgagaac cgcttcgcgc ccgagcgcaa
     1861 ggtgtccgcg atgcgcttcg cgggctggta ctacctgtcg gtccatctga accctgacgt
     1921 ggcccagaag ttcggcaggg cgccgctgga cgtgacgctg cggatcagcg tcgagggatc
     1981 gccgaggccg gggcccgcgt acgccggatc ggcgaagccc gccgacgagt tcagcgtcac
     2041 ggagcgggac gcggaggccg cgaggcgggg ggagtcggac gcttcggcca cctcgaccgg
     2101 tgggggcggg ggcgacgacc gggtgatggt gatgatcgcc gtcgggggga tcggtaccgg
     2161 tgtggggctg ctgacgatcc tcggcgtgtg gacgctgatc gcgcggcgga gggccgcggc
     2221 cgtggccctg cggggagctt cggccgtgcc gggggcgact tctccggcgc ggttcgggcc
     2281 gccgcggggt tggtagcggg cgcggtggcg gggctggggc gtcggatgcc tgtcagatct
     2341 gtgccagggc ccagaacccg acggtgaggc aggccagcgc gaccagcagc atcgggaccg
     2401 ccaccttcgc gggtgggccg ggtcggcgcg gccggacgcg ggagtgggag cgggagtgcg
     2461 ccgggcgggg ctgcgtcacg gcctgactcg gggccgttcg gctcgcgatc gcctggtccg
     2521 aaaccggcgg gctcggaggc ggaacctgag cggcgtgagc ggtgtatgga taagtaggag
     2581 cgtggcggtg ggcctgatcg ggggaggtca catgcgtggg ttcgggcgtg ggtgcctgcg
     2641 ggggaatggg agcagggggg accggagcac gaggaacagg gggagtggac ggcgaggggg
     2701 gcgcggtcgg ctgctggggc ggcggcagag ggaagctgcc ggtgtccgag gcggtggacg
     2761 gatcccagcg ggaggcggtg gacggctccc agctggcggg ccggcccgag ccgacggacg
     2821 ggggcgagtc gatggacgga tcagcagcgg caggtggatc cgtggtggca gacggatccg
     2881 gtgcggcagg ctgacccggt gtgagggacg gatcccatgt gaaggagcga tccggtgcgg
     2941 cgggcggacc ggaggccgcg gccgggtgcg acgtcgatgg ggggatcggt gcgggggccg
     3001 ccatcgggcg tgggggcgtg gcgggtgcct cggggatcac ggggagcacg ggggcgggcg
     3061 catggcccgg ggcaggaggt acgtggcccg gggcaggcgc gggggcaggg tgacgtcgtc
     3121 gtgcggagtt gaggggcccg tcgggtccga accccgtggg caggggcgcg agttggtcga
     3181 agatctcgac gagttcgtcg tccgggcccg gctcgggcag catctcggca gccgacgcca
     3241 gcgccttgcg cgcgcccgtg gcggtgcgga agcgcgactg ggggtccggc tggagcagcg
     3301 tggcgatgac ctgccagagc ggttcgggca tgccctgtgg ggcgcgcggg gtgccgtgct
     3361 cggcgaagtg ctcgatcagc gccttggcgt ccggcttggc gccttcgagg agatagaggg
     3421 cgaccaggcc gacggcgaag aggtcggcgg tgaagtccgg ttctgcgccc atcatctgct
     3481 cgggggcgaa gtaaccgggc gtgcccacca catagtcggt ctcggtcagc cggggctcgc
     3541 ccttgcgcat cgagatgccg aagtcggaca ggcgcaggtg cggacggccc gcgccggtgg
     3601 cctcgagcag gatgttggcg ggcttgatgt cgcggtggac gacgccctcg gcgtgcaccg
     3661 cggcgaggcc ggagaggagc tggtcgagga gcgtgcaggc gaagcggggc ggcagcggtc
     3721 cgtagtcccc gatcacgtgg gccagcgagc cgccggcgac caggtccatg gtgaacagga
     3781 ccttgtcgtc gtcggcggcc cagctggcgg gcgcgagtac atgggggtgg tcgatgcgca
     3841 gggcctgttc ccgtacgaac cgcaggagcg agtgtgcgtc gctctgctgc aggaccttgg
     3901 cggccacata gcggtgccgc cggtggtccc aggcccgcca gacggctccc actcccccgt
     3961 gtccgactgg gtcgaccagt tcgtaccggc ctgcgaagac ctcacccatg gtcgcgctcc
     4021 gctccccttc cgggccgcgc ggcgacccgg ccgacggctc agctctggtg cgcctcgtag
     4081 tgggcgaccg cgtccgcggt gcgcccggcg ccgtacaccc ggaggaactc tgccagttcc
     4141 gggtgggtgg gggcgaggga gtccgccgca tcgatgatgt cgcccgccgc cgcgacggag
     4201 cgcagcagtg actggatctc gcgcaccacg cgcttgaccg tgggggcgcc cgaactggtc
     4261 gccgtctgtg cggtgttggt caggacggag ccgccctggg acttcttgat ctcgtccatg
     4321 cggtccgtcg cctcggcggc gctcacgctg ccgtcagcca cctgaccggc caactcctgg
     4381 aggagctgga cgcgttggac gaccgcgggg ttgccgatct tggcgcgctg gccgctcatc
     4441 agctgggaga gcatcggggc ggacaggcca aggactccgg cgagccgtgc ctggttcagg
     4501 cccaggtcat cgatgagccg acggaagagc gcccccagcg gctccccgta ccagttccgc
     4561 tggagctccc gtgctctcgc ggtggtgtct tgttgtgcgg cgtccattgc gtctccccat
     4621 cgcttcccct aagaccgtgc ttcgctgccg cgaaccacgt cgagcatctt acggagcgtg
     4681 gtcgtggacc gggaccccca atccttttgc gagatccggg gggtgacccg gtactctggt
     4741 ctgcggtgct caccggggac gtggttcttc cggtccggtg catcgttttc ggggccttag
     4801 ctcagttggt agagcgctgt ctttgcatgg cagatgtcag gggttcgact cccctaggct
     4861 ccacggcccg aaagcccccc gcctgcgttt atgcaggtcg ggggcttttt tgtgtgtcct
     4921 tgcgtgttct gtgcgggtac ggggcgcccg tagggcgtct gtgccgtggc gttcaagggc
     4981 ccgcccgatc ccggggtgcg gtgctagcct gaggctatct aacagtgtta ggaagagtgc
     5041 ccgggggcct ctgcgggcac cggatccggt ccagggggtt acgtgactgc cgatgcttcc
     5101 gctccgatag gtctgcccgg agggccctac gatcccccgc acgtccgcgt gctctccctg
     5161 gccgccgcga agtgggtctc ccagccgatc gccgtcctgg cctccctggg agtggcggac
     5221 gcgctgggag acgggccccg cgcggtggag gacctcgcgg ccgccgtcgg tgcgcggccc
     5281 ggtgccctgg ggcgctgtct gcgcgccgcc gcgtcggtcg gtgtcttcgc cgagcgggag
     5341 gacgggacgt acgaactgac gcccatggcc gggagcctgc gggtcgatgc gcccgactcg
     5401 atccgcaact gggtcctgat gctgaaccag ggtccgatgt gggattcctt cgggaagctg
     5461 gaggaggccg tgcgcaccgg gcggtccgcc ttcgaagtgg cgcacgggcg gccgctgttc
     5521 gagcacctcg acaaggacgt ggagttccgc ggcgtctacg agtcggcgat gggcgagctc
     5581 acctcggagc tggccgggga actggcaccg gcgatcgact tcagcggcta cggcacgctc
     5641 gtcgacctcg gcggcgggga cggtgagctg ctcggcaccc tgctgcggca ctgcccggag
     5701 agcaggggcg tgctcgtgga gcgtccgcac gtcgtggagc gggccagggt gcgccttgcc
     5761 gagctcggcg tcgtggaccg gacgcgcctg gtggcggggg acgcgaccga agaggtgccg
     5821 tcgggcgggg acgcgtacct gatcaagaac atgctgcact gcttcgacga cgccaccgcc
     5881 cttgccgtgc tgcgcagggt gcgggaggcg ggcggcgagg atgcgcggct cttcgtcatc
     5941 gaggtcgtgg tgccgccggg caacggcttc cactgggcga agctcatcga catcgagatg
     6001 ctcgccgaca acgacggtcg tgagcgcggc gaggacgagt ggcgggagct gctcggccgc
     6061 gccgggttcg agctggagcg cgtcgtaccg gcgacgccgc cgcagtcggt gctgatcgcc
     6121 aggcccgttc gccgggtcgg cgggtgagaa ggaaaccgac aggaggagag attccatgcg
     6181 agcaccgtgg aagggcgacc ccgtcgagcg cgcacgcaac cgcgcccggc agcgggagct
     6241 gcagcgtcag caggacgcgg agcaggcccg taaccgtgag cgtcaggagc gtgaacaggc
     6301 cgagcgggac gctcggcagg cgcgcgacga gcagaacgac cgccgttagc gggacgggca
     6361 ccgcctggag cgggccgagc gccgcctcgg ctcagtcgcg gtcccggctc tccaggcggc
     6421 tgcgcaggcc gtcgagcaga cggtcgagcc cgtaggtgaa gcgcgcctcg atgtcggggc
     6481 gcgcgagccg ggcgccgacg gccacgacgt tcggatactc ctcgggggag agcccggcga
     6541 ggcgttcgcg tgcctcctcc aggaacttct tggggtccgc gccgcgcgcc acgtcggccg
     6601 agagcgggga cgtctcgtgc aggacgaagc cctggacgta ctgcgtcagg gagtagaggg
     6661 agtccgccgt gtcctggtcg tcgaagcccg cgcggcgcac cgcgccgagg atgacctccg
     6721 cgtggcgcag gaagtgcggc cccagctgga gccgtcccgc gagcacgcgg cccgagtcgc
     6781 gcttggacag caggtaggcg cggtactcga gcatcatgtc gcgcagctcg gtccgccagt
     6841 cgccatcggt acggacgtgg gcgtccaggc gcagctccgc gaggagggcg tcggcgagca
     6901 ggtcgaggag ttcgtccttg ttgcggacgt accagtacaa ggacggtgcc tggatggaga
     6961 gttcgtcggc gaggcggcgc atggagaggg cgtcgaggcc gtccctttgg agcgtgcgca
     7021 gcgcggcgtc ggtgacggcc tccagcgtga tcgcgggccg tggctgtcgc cgggtcgtgt
     7081 tcgcggcacg ctgggctccc atgcgccggc tccctcctga agctccgccc cggtgaaccg
     7141 ggctggtcct ctaactatgt tagaggacca gggccgtccg ctcctcagcg cagttggggc
     7201 aggacctcgt ccctgaagag ccggaagctg cgctccatcg tcgccccgtc ctggccgccg
     7261 aagtcgacct gccacaggaa ggtgtcgacg gagaggaagt cccgcagctg gcgagcccgt
     7321 tcgaggacgg tggcgggtga tccgaccacc gcggtgccca ggctgcggaa gtcggcgatg
     7381 tcgaggttgc gcagggtcaa agccatctgc gagtacgtcg ggtagtcctt ggacgaggtg
     7441 tgcatccatg cctccgcggc ctccgcccac acggtcaggt actcgcggag cagcgggtcg
     7501 gccgtctcgt acgcctcgtc gtcggtctcg gcgacgtaga gcgggatgga gaccgccacg
     7561 cgcgggcgcg ggccgtcggg ggtggagccg tgcacgtcct cgaacgtgtc gaggtagacc
     7621 tccacgaggt cgcgtacgcc cgccaggtcc tgctggcggg gcggcggtgt cacgagcagc
     7681 ccgaagccct gctcggcgag ccaggcgaag ctctgccggg agcggaccgc cgcgccccac
     7741 accggcgggt gcgggcgctg caccggagcg ggcagcgagg tggcgtcgcg gaacgagaag
     7801 aacgggctct cctcgctcac cttctcctcg gtccacagcc gcaggacggc cgcgatggtg
     7861 tggttgaagc ggtccctgga ctcgtccatg gagaccccga acgcggtgaa ctcgtacggc
     7921 atccaggcgc gcgcgaagcc gacgtcgagg cggccgccgc tgagcgcgtc gaccatcgcg
     7981 gtgtgcgcgg cgagctggat ggggtggtgg aaggcgggca ggacgcagcc ggtcatgagg
     8041 cggatccggg aggtctgcgc ggcgacggcg gcgaggaagg tcagggggct cggacagtag
     8101 ccgccgtact ccttgaggta gtgctcggtc atcttcacgt agtcgaggcc cgcctcgtcg
     8161 gcgagacggg atatccgcag cacgtcctcg tagtactcgc gggcgccccg ggtggcggga
     8221 cggcagtccg gaagcagtga aatgccgtgt tgcacggtgg tttcctctca gtcgggcttc
     8281 gagatcaccg gcggcctgcg ccggttgccg cggggcgttg tttcacgtga aacagccggt
     8341 gtttcacgtg aaacggtcgc ttcccttcgg tcgggatgag cagggcgaag aaggcggcat
     8401 cggcggcgag caggggcacg agggtgctgc cgcgccagta caggacggtg tgcacggtcg
     8461 ccatgaggac aacgggcgcc caggtctccg gagtgcgacg ccggcctgcg ggcatgcctc
     8521 gtacgacgac ggcgatctga gcgaggaccg cgacgccgac cgccatcgcc gctcccgccc
     8581 ccgcgagcgc ctcggtgagc gtcgcccgaa agacggtctc gtcgcagagc acggccgtgg
     8641 cgagcgtgac gacaccccag acgccgggcc cggcgacccg ggccttcgcc tcctcggcca
     8701 cgtgtccacg ggtgagggag agccagtgcg tacgcccggc ggcggcgcgg gggcgggcgg
     8761 atgtcgtggc ggtggcggtg gcgggccgga gccggggcat tctgcgtgcg gcggcgagca
     8821 ccgggcgcgt ggcgcgcagg gcgtcgacgg tgtccgccag gatgctggtc aggaagaccg
     8881 ccaccgcgaa ctccccccag cccagggcga gtccgacgat caggagcggc agcagcgtgg
     8941 cgtcgggcgg tgcggggtgc cagggcagga cgtcgacggc gatggcggcc gcgacggtca
     9001 gggctccggc ggccgtggcc gcgagggagc gggcccgtgc gggggcgagc cgccgcaggc
     9061 gcccggccag ccagggcgcg aggaaaccat aggcggcaca ggtcaccacg agtacgagtc
     9121 cgccggccac cacaggcccg gggccgctca tgacgccacc gtccggcccc gggcccgtga
     9181 cgcccgacgg tccttgtccc gtgcgtccgg tgcggccccg cgcaccgtgt tctggtagcg
     9241 ccagatccgt acgttgaaga gcgcgtgcgt cacgaccgcg cccagggcgc tgccggtggc
     9301 cagggtgagg gcgagcgcga tgaccgagag cgggagtttc gccgcgacct gggcccagcc
     9361 gaagaagatg tgcgagagcg cgaacgcgcc tgtcgccgcg agcaggatca acacccgctg
     9421 cgcgaggccg tgttgggtca gagcgacgcc ggtgagcgtg ccgcggaaca cgcactcctc
     9481 caggacgccc accgcgacca gccagcccag cggcagtgcc acgtccgtgt cccggtggct
     9541 cggtgtccac tgctgcctgg tcgtcgtggc cgacgaggcg cccgcgagcc gtgcggcctg
     9601 cccgacgggg cgggtggccc gggcgcgcgg cgcggtggcg ggggcccggc cgccgcgggt
     9661 cgtgccgtca cggttcgccc cgcggccttg gtcacgcgcg gccgagcggg cggcccgtcg
     9721 cccgagccgc cgtgtgatca gcgtgtccgc ggtggccacg aggggggcga cggcggcgcc
     9781 gagcagcggg ctgaccagca gtccccagcc gacgccggag ccgagcaccc ggggcccgac
     9841 caccagcagg ccgcacccgg cgacgaccgc gagcaccgcg gcgtacacct ggagcgtgtg
     9901 tacgccgcgg tggtcgaaga agcgcacatg caggtgtgag gcgagcgcca ggcacgacag
     9961 cgcgcacagg gtgagcgcgg cgagtgccgg ttcccgcagc tcatgggtat ggatgaggga
    10021 cgtcatcggt aaagcccccg tagtcggcga agcgcgggtg cgcggccggg acggcgctgg
    10081 gcagcggcag actgaccgtc tccggcgacc acacccgcat cgcgtggaag ccgagcgccc
    10141 gcaggtcgcg ggtggtcaga tcgccgaagt agagctgctt cccggagtgt gcgaaggcgt
    10201 cgaccagggt gcgtacggcc tccttgaccg ggcggtcgtc gtccggcgga agctcggagg
    10261 cggcgcgttc ggtgtgccgg gcgaagcgcc gctccaccgt gcgtgctccc tgggacgtgg
    10321 cgtacaggcc gacgttgcct tccaggtcgt agatgtcctc gtcggcgggt gtgccctgca
    10381 ccgcctgctc gaccgcgacc caggcggcga gccactgcac accggccgcc tccaggagcg
    10441 cgcggtacat cgcgcgggcg agcgaggcgc cgctgccgag cccgatggcg acctcgggca
    10501 cgagccccgg cggctggcgc agcaggcagg cgatggtgaa gccgggcagg tcggggctcg
    10561 gcagggcgtg gaactcggga cgcggggcgg aggcggggaa gtacgtgtcg acgatcgcgt
    10621 cgaggtggcg ggtgcgggcg tcggggcgga tcaggacgct ctcggtgcgt ccgtaccagt
    10681 gccccatcgc ggcgtcgacc tgcacgactt cctcaagtgc cgcgcgcagg gcggcctgtg
    10741 gcgtggtgtg tgtcgcggtg ccggtggtga cggcgggcag ggtccagggc tcatcgcgct
    10801 cacggacgta gccgagcagg aagcgctggg cgggcaccca gcaccgcgac ccgtccgtca
    10861 gcgagccgac ccgcagccac ccggagggcg catcggcgtc gaaggggtcg aaggggaagc
    10921 cctcccgcgc gtactgctcg tcggtgaaga gccggaaggc gctccgcggc agcacgggct
    10981 cgccacgcgc ggccagttcg gcgtacgaga ggtggtggat ctcgaagcgt ccgtcgaggg
    11041 ccgcggcgta tccggagtag cgctccagcg tctcggcgag cgagcggatg tggctctcga
    11101 acgggaagat gccgtagccg ccgatgtgat agctccccgc cttcggcggc ggctggtcct
    11161 ggcgtacgtg cacgcccgtc atgtcggcgg tgccgaccag gagccgggga ccgcccggat
    11221 agcgcgtcag gaagcccatc gacgtggtga ttccgcagag cggtccgtgc atgcgggcgc
    11281 gcagccggtg gacgcgcgtg tcctcgtcct ggtggagggt gagccgcatc agccctccag
    11341 ccaggtgcgc gggtcgaagt ggagcgtctc gtcgtcacgc tcgggcaccg ggccgcagcc
    11401 ggggcagccg ggcagcggaa gcacctcctg gtaggcgatc tccatgctcg gcaggtagca
    11461 gccgaggacc ttctcgacgg tgaacgtcga gccgcagctg aggtagttgg tcgcctccat
    11521 cgccaggtgc gagcagagca gggactgcac ggggccgtag acgggcgggg ctcccgcgag
    11581 gacggcggag cgggcgagcg ccgccttgta gcgctggtat ccggcgctct cgcggaggtt
    11641 catcgtcacg cgcgtctcga agcactcgaa gcacgcggag cgcccggcca ccatggtggg
    11701 gccgacgaag aggaaggggc cgtccaccgc cgcgtacgtc cagtcgatgc ccgcggcgcg
    11761 cgtgagccgg ttgaggagct gggcgcgcac cgggtcgatg gtcctctcgg cgagcagcag
    11821 atagctgtcc tgccaggggc gcagcgtctc gacggcttcc tcgaaggcga ggccgtcgtg
    11881 cagcacggcc ggggcgaggg cgtcgaggcg ggcacgtacg gggtggtcgg cgcccggtat
    11941 gaggacgtcg ccggtgacct cggcgggcag cagggaggcg gtgagctcgc acaggtcggt
    12001 gtcgccgagc aggacgacgc ccgtcgcgac cggctccgcg gtgcggccac cgagcgcggc
    12061 catgtcgtcg aggtaggcgt ccagggcgtt gccaggagct tcctcgatgg cgtcgaggcc
    12121 gtagagatgg tcgaccaggg cctcgacctc gacccgcgag acgccctcgc gcttggcgag
    12181 gtcgcgccgg gagagcgtgc cgtcgaggcc gctgatcagg ttgaagaggg tgccggagcg
    12241 ggagtcgtcg gtgagcgtgt aggacttggc gttccacaca ccggtgcgca gctccacgac
    12301 gtcggggctg tggccgatga cggagaagga acggcggacg cggggctgcc cgttgtccgt
    12361 tggctgccgg ttgtctgtca tgcgaagcct ctctgccgct ctccgcggcc ttcggtacgt
    12421 ccgggaggtc aggccgcgcc gagcagcacg gtgtgcagca gcgtccggtg cacgccgtcg
    12481 agaccgagcg cggagtgcgc ctcgtcgtcg tagaagccgg agaagtccac gctctccagg
    12541 ccgagtccgg tggcggccag atgggcgttc tgcgcgatgc cgcccgcctc gtggaacatc
    12601 gaacgcatgc cccgtggccc gtacttgcgc atcgaacgcc aggggttgcc gacgagcagg
    12661 atgaccgcgg ccgtgcggtc gaagtcgatg gagccgtcct gcgggtcgaa ggaggcgatc
    12721 agttcggtga cggcctccgg gcccgcctgg gtggccagtg actcctccac gggcaggaag
    12781 cggtgaaggc ccggttcgag tcccgccacg ttccgcgcgg cgagccagat ctccacgggg
    12841 tagagcccac cggcgctcgg cacggtgcga aagcccatgg tgaggggcgc gccgtcggcg
    12901 agctcgatgt cggcctccgc ggtgaccgag cccgcgaagc gcaggacgga ggtgatctcg
    12961 tcgaggccga cgggggctcc ggagaagtcg cggccgctgc gcctgcgcag caccgtctcg
    13021 gtgaggcccg cgtcgatgtc cgcgccttcg gggaggggag tgcgtggtgc gctccggtgc
    13081 ggaacgcggt cctgacggga ttggaccacg gccatgacgt cggagaagta atagccgatc
    13141 gacagcaggg cggagcggtc ccagcgccgc attcgcgtgg ccatcaggaa ctcttccgcg
    13201 atgcgcctga aggtgcccga cgacagattc tcgaagcgca tcgagttggt ttgcaggccg
    13261 actcccgagg cgttcggact catcgtccga taggcgctcg tggccaccga agattgaata
    13321 agacgcgctt gttcagggct gtccgcaccg ctcatgtaat ggcgtccctt cgttctttga
    13381 attcaccgac gcgcggcagg tcatggacct gccgcgcgtg gttttgcggg ttacttgcgg
    13441 acaacagcgc cgcagcagca ggaacaggcg cccgggacca gaacggcctc gtcgcgtccc
    13501 gcgccgaagg gctcgagggc ggcctggggg gtgctgttgc ggtgctcggc gaccttctcg
    13561 gactgcagct tcattacagc tccttcctaa ggaacaagtg cgcgtcagag cacatcggcg
    13621 cacttcttcg ccttgtctgc gtaccttgtt gatgtttctt gctgtgtgct ttgtgagctt
    13681 tgacttcagg ctcacggtcc cgcaaactaa cagtgtttgt ctgagggcac aaggcttgtt
    13741 cgcgagacca attgagcggt aaacgaagac tctaattccg ttttgcttct tctttgaact
    13801 ggataaccga gaatttattg agtgtccgct cgtcggctgt taccaacgac ctcatggccc
    13861 tcgatggagt acctgacgaa gcaattgatc tcctgaaccc cgcgttcatg gccgaccccg
    13921 ggcccggcta cgcgcggctg caccgcgtcg atccggtgac ccgcgtccgg ctgcggccgg
    13981 ggctgaaccc ctggctggtc tgcggctacg acgaggcgat ggaggtcctc tccgacccgc
    14041 tgttcagcgt cgacccggcg agcacgggtg actccgtcag ggacgccatc gccgtgggcc
    14101 gcgccgagga gaagaccgcg ctgctcggcc gccacctgct gagcgtcgac ccgccggacc
    14161 acacccggat gcgccggctg atgtcccgcg cgctgaccgc ccgcaggatg cgcgccctcg
    14221 aagggccgat cggggacttc gcggacgcgc tgctggacaa gctcgacgcg cggggcgaac
    14281 ccgggttcga cgtgctgggc gactacgccc tccccctcgc cgtggaggtc atctgcgagc
    14341 tgatcggcat ccccgcggcc gaccgcccgc gcttccagga gtggggcgcg ctgctcgtgc
    14401 gctccgaact ccaggacgat gccgccttcg acggcgcggc ggacgagatg gccgggtact
    14461 tcgtcccgct cctcgcggcc cgtcgcgagg agcccgccga cgacctggtg agcgccctgg
    14521 tgaccgcgca cggcgaggaa caactggacg actacgagct gatatccctc gtctaccagc
    14581 tcttcttcgc gggccacgag tccagcgcgt acctcatctg caacgccgtg ctgcggctgc
    14641 tgcgccaccc cgacgagcgc gccgcgctcg ccgccgagcc cgcgctcgtc gagcgggtga
    14701 tcgaggaagt cctgcgtgtg gacggcccgg tgaaggtccc gacctggcgg tttccgctgc
    14761 gggacatgga gttgggcggc cggaaggtgc gggcgggcga gccggtgctc atcctgctcg
    14821 gcgcggcggg ccgcgacccg aagcgcttcc cggacccgga ccgcttcgac agcggtcgca
    14881 cgggccgcca gcacctggcg ttcagccacg ggatccacca ctgcatgggc gcggcggtcg
    14941 gccgcacgga gggccgcgtc gcggtgggcc gcctgttcgc ccgcttcccc ggactcgaac
    15001 tggccgtccc cgcggagggg ctgcgctggc gcgacaacct gatgatgcgg ggcgtgtgcg
    15061 agctgccggt gcgggtggcg ggctgaacct cattgaggtc tgagtcccag tgcgggctga
    15121 gttctcagta cgggctgagc ctcattcggg agcggacaca cgagcgccgg acgggccccg
    15181 gcgggggaat gcggtggccc gtccggctgt ctgtgcgagg gctggcgcgg cgcctcagag
    15241 gcgcccggcc acctgcccgg cggaaccgga gccttcggta cccgtacgct ccgtcagttc
    15301 ggtctcgatg tcgtcgcggt ccctgccgcg caccaggaag tacacggcca cggcggtcac
    15361 caggagcagc gcgccgccga cccgctccgc caggtggagc ccgtccacga aaccgtcgtt
    15421 gaccagcgcg gtgatccgcg cgctgccccc gccgcccgcg ctctgcgcgc cgcccgcctc
    15481 gacgccgcgc agcacctcct cgcgtgcggc ggcgggcacg tgggcgtcga tgagccggtc
    15541 gcggacgctg tccgtcatcc gcgtggtcag cagggtgccg agcacggcca cgccgaagac
    15601 gctgccgagc tgacgcgtgg cgttgctcgc gccggacgcc atgccggacc gcgcggcggg
    15661 cacccgcatc atcaccaggg tcgagatcgg cgtgagggtc agaccgatgc cgaggccgac
    15721 gagcaggacg acccaccagt actccgcgta gcgggcgtcc gcgccgtaca gggacgcccc
    15781 gaacatcgtc agcgaggcga acaggatgcc gagtccgagg gggatcgcgc cgcccacctt
    15841 gctcgtcatc cagcccgcca gcggcgcgga gaccatggcg agcagcatgc ccggcaggat
    15901 cgcgagcccg gcgcccacgg cggaccagcc gagcacggtc tgcagccaga gcatcaggaa
    15961 gtacgtgatg gcgaagagcc cgaagtagag gacgaacccg gcgatcaccg agccggtgaa
    16021 gacccggtcg cggaagaagg acaggtcgag catcggctcg cgcacgcgca gttcggtgat
    16081 gacgaacacg atgaggagca cgccgcccgc gaggtaggtg ccgaccacca ggcggtcgct
    16141 ccagccgcgc gagccgccct cgatggtggc gtagacgatc gcggacatcg cggcgaccga
    16201 gaggacgagc cccgccgggt cgaggcggcg ctcgggattg gacgactcgg ggaccatgcg
    16261 caccgcgagc acgaagccga gcaccgcgat gggcacgtac atccagaaga tgccctccca
    16321 gccgaagttc tccaccaggg ggccgcccac caccgggccg aaggccaccg cggcgcccgc
    16381 caccgccgcc cagatgccga tggcggtgcc gcgctcgccg ctgtccgtga agacgtgccg
    16441 gatgatcgag agggtgttcg gcatcagcag cgcggcgccg acgccgagca ccgcctgggc
    16501 cgccacgagc acccacaccg acccggcgag cgcggagaag accgcgccgc cgaggaacac
    16561 ggcgaggccc gtgaggaacg tcttcttacg tccgaagcgg tcgccacagg cgccgccggt
    16621 gagcatcagc gcggcgaagg cgagcgagta gccgctgatc acccactgga tgtcctggat
    16681 gccgccgttg aggtcgtcct ggatgtcggg cagcgcggtg gagagcaccg tgctctgcag
    16741 catcgtcagg gcgagtggga cacagagcgc ggggagcgtc cggtaagggc ttggcccctg
    16801 tcgggcgggg gcgtcgaccg ccatcacaca ccgtcctgtc gagtcgtctg tcgcctgttg
    16861 gtccggcgga tctgtctaac agtgttagac cactctaaca gtgtgagttt gggctcggga
    16921 agcggtgttc gcgggctgtt ccacgtgaaa catcgacggg tgcgggcggt tcggtgacgg
    16981 gtgggacacg ggaaacgccg aggggcggga gaccggttgg tctcccgccc ctcggcgtgg
    17041 tgtggtcggc gctgcggctg ctcgcccggc tgcgcccggc tacttgtccg ctcggctgag
    17101 cccggctact tgtcccgctc ggccgcgtcc gcctcggcct cggcctgctt ggcctggacc
    17161 tcggggtcga gaacggcctg cgcgctgccg tcgacggggg tcagcgtggt gtccgggacc
    17221 tccgtggcgg ccggcggctc gaccagccag tcggggttgg cctgcttgtc ccaccacttc
    17281 caggcggcga aggcgccgcc cgcgaggatg ccgagtacgg caagcctctt ggtgaggcgg
    17341 cccgccctgg cccggcgctc gtgcttgcgg gccaggcgcc ggatctcctt cggcgtgacc
    17401 tcgccgcgca gggcggcgag tgcggccgcg ccacgggcgg cggcctcgtc gcggacgggc
    17461 tgtgcggcgg ccacggcgtg ctcgatccgc ggcttggaat agtcggcggc ctgccgggca
    17521 gccttgcggg tgcggacggc ggcctcgtgc gcggcgtggt cgaccttcgg cggcacgtgc
    17581 gtgcgggcct gctcgacgcg gggtgctacg tgggcgccgt actggacacg ggcttgttcg
    17641 gcggcctggg acaccttggg tgcgagccgc acgcgcgctt cgtgggcgta gtgggcggcc
    17701 cggtccttgg ccgtgtcggc gtagggcgcc accgcgtccg cggcgtgacg cacgctgtcc
    17761 ttggccgagc cggtcgcggc gcgcacgctg tcgatgcggg tcacgggatc ctcctcctcg
    17821 gtggcgtata ggtatgtcac ctttccaccc tttcagggat catgccttct ggatgtgaag
    17881 aagacctgtg agggcgggca tccgggtcac ttgcgcgttc cgttcaattc gatcgattcg
    17941 gtgcaagaag agctcttcgc cgacaatgcc acggatagct cgggtgcgcg cccagtcggc
    18001 ggctactcgt cccaatccgg tccgtgcgag gatcgggggg tcacagaaga caacggaagg
    18061 cagatcgtgg ctgagcagct ttacgccacc ctgaagacca accagggcga catcgaggtc
    18121 cggctcctgc cgaaccacgc gcccaagacg gtcaagaact ttgttgagct cgctcagggc
    18181 gagcgcgagt gggtccaccc cgcgaccggc aagaagacct cggaccgcct gtacgacggc
    18241 accgtcttcc accgcgtgat cagcggcttc atgatccagg gcggcgaccc gctgggcaac
    18301 ggcaccggtg gtcctggcta cgagttcgag gacgagttcc acccggacct cgccttcgac
    18361 aagccctacc tcctggccat ggccaacgca ggtccgggca ccaacggctc gcagttcttc
    18421 gtgactgtgt cgccgaccgc gtggctgacg cgcaagcaca ccatcttcgg cgaggtcgcc
    18481 aacgacgcgg gcaagaaggt cgtggacgcc atcgcggcca cccagaccaa cccgcgcacc
    18541 gaccgcccgg tgaacgacgt ggtcatcgag tccgtggtca tcgagacccg cgacgcctga
    18601 tccacgcgta ccgacgcgcg ccggtgcgtc gtgcgtcagc gtgagggaac caaaccgccc
    18661 cgcccgtccg taaggaaggg cggggcggcg cgttgccacg cgtgccgtcg cagtgccttc
    18721 gtacggagat tgaggggacc ccatggacca ggcgccaggc agcccgcagg agccgcaagg
    18781 ggcgtcggcc ctacccgggt gctaccggca cccggaccgt gagaccggca tcagctgcac
    18841 gcgctgcgag cggcccatct gccccgagtg catgatcagt gcctcggtcg gcttccagtg
    18901 cccggagtgc gtcagggaag gctcgggcac cggtcacgcg ccgacggcca accagccgcg
    18961 cacggtcgcg ggcggtgcgg tcacggccga tccgcgcctg ctcaccaagg ccctcgtcgg
    19021 gatcaacctc gccctcttcg tggtgcagct ctcggtcggt gacagcttca ccgaccggtt
    19081 cgacctgatc gggcgggcct tcgtgccgga gctcggctcg gtcgagggcg tcgccgaggg
    19141 gcagtggtac cgcctggtga cggcgatgtt cctgcacagc agctatatgc acatcgcctt
    19201 caacatgctc agcctgtggt ggatcggcgg cccgctcgaa gcggcgttcg gccgggctcg
    19261 ttacctcgcg ctctacgggg cgtcgggcat cgcgggcagc gcgctgacgt acctcatcgc
    19321 cgagccgaac cagccctcgc tcggggcgtc cggcgcgatc ttcggtctgt tcggcgcgac
    19381 agcggtcctg atgcggcggc tgaactacga catgcggccg gtcatcgccc tgctggtgat
    19441 caacctgatc atcaccttcg gaccgggatt caacatcgcg tggcaggccc acgtcggcgg
    19501 tctcgtcggt ggtgtcgtcg tcggctacgc gatggtgcac gcgccccgcg agcggcggaa
    19561 cctcatccag tacggcagcg tcgcgctgat cgttctggtg tccctggtca tggtcctcgt
    19621 caggaccggt cagctcacct gacgtgctcg cgttgtccac agcgtgtgcc ggatcttgtg
    19681 catgctgtgg ggaacaaccg tgccccttgt ccctgacctg ggtttcccca ggaaggacaa
    19741 ggggcgagcg gcgaacagag atccggtggg tcagtcacac cggcgtcaac ctccggagag
    19801 ttatccacag atcttcagac cttttcccca tgtggatagc gctgtggata actcagggca
    19861 aggcttgtgc gtggagcgcg gatgcgctcc gtggtgccgc gcctacttcc actgcgtgga
    19921 gacgccgaat cctgccgcga tgaagccgaa accgaccacg atgttccagt ttccgagcgg
    19981 gtcgatcggc agcttgccgt ccgtgacgta gaagacgacg atccaggcga gcccgatgag
    20041 gaacatcgcc agcatcaccg gagccaccca gctgcggttg gtcagcttga tgttcgtcgc
    20101 cttcttcgag ggcggcggcg tgtagtcgtc tgccttcttg cggatacgtg acttcggcac
    20161 gagggtctct cctgtcgatg cgctgcgtgg ccgcgcaggt aactgtcgtc tgtcgccggg
    20221 cggggtgcta cggggagctg gggcctcccc cgggcgtccg ttagcgtagt gcttccgcgg
    20281 cgctgaagga gataagggta cgttgagcaa ttctgccgac tcccacaaag gtgccggtcg
    20341 ccgcccccgc tggcgcccgg ttcgggtgct tacgggcgct gtgttcgcgc tggccgggct
    20401 gatcttcttc accagtttca acacggccaa aggcaccaac atccgtaccg atgcctccct
    20461 gttgaaactc tccgacctca tccaggagcg cagccacaag aacggcgagc tcgacgagtc
    20521 caacggctcc ctgcgcgacg acgtcgaatc gctcgcgcag cgcgacaacg gcggcaccaa
    20581 ggccgacgac gcccggctca aggccctgga ggagaacgcg gggaccaaga agctcggcgg
    20641 cgaggcggtc accgtcaccc tcgccgacgc cccgccgaac gccaccgcca agctgcccgg
    20701 ctaccccgag ccccagccga acgacctggt catccaccag caggacctcc aggccgtggt
    20761 caacgcgctc tggcagggcg gtgccgaggg catcaaggtc atggaccagc gcctgatctc
    20821 caccagcgcc gtgcgctgcg tcggcaacac cctgatcctc cagggccggg tctactcccc
    20881 gccgtacaag gtgaccgccg tcggcgaccc cgacaagctc aagaacgcgc tcgccgcgtc
    20941 ccccgagatc cagaactaca tgctgtacgt caacgcgtac ggcctcggct ggaaagtgga
    21001 cgacgacggg gcggtgactc ttccgggcta ctcgggcaca gtggatctcc actacgcgaa
    21061 gcccgtggag tagccgagta gccgagtagc acccggagta gcacccaggg aggggccgtc
    21121 ctgtgtcggt gcgtgtgctc gtcaggacgt tcagcgaact gtgcgtcacc gtcggcacgt
    21181 tgatcgtgct cttcgtggtg tacgtcctgt tctggaccgg cgtgaaggcc gacagtgcca
    21241 tggacagcca gatcgacgcg ttgcaggacc agtgggcgcg gggcgcggtc tccaccgggc
    21301 ggggcggcgc gggcgagggc gacgacgggg gcggcaaggg cgccgacgac gccgcgccgc
    21361 agaaacccgc cccctacaag gacggcaagg cgttcgccgt catgtacgtc ccgcggttcg
    21421 gtttcacgtg gaacaagccg gtgctccagg gcaccggcac cgacgtcctc aagaagggcc
    21481 tcggccacta cgcctccacc gcccagctgg gacagaaggg caacttctcc gtggccgggc
    21541 accgccgtac ctacggcgat ccgttcaagg acttcccgaa gctgcggccg aacgacgccg
    21601 tcgtcctgac ggacggcgcc acctggttca cctaccgcat cgacaagaag ccctaccgga
    21661 cgctccccag cgacatcgga gtcattgatc cggtccctcg caagtcgggc tacgacggcc
    21721 ccggccgtta cctcacgctg acgacctgtg aaccggagtg gggccacagc caccggctga
    21781 tcgcctgggc acatctcgat gccactcagc ccgtggaggc cgggaaaccg gaggcactgc
    21841 gccgttagtc tggtgccgta cggcgagcga ggcccggtgc cgtacgcgac ggaagggacg
    21901 gcatgtacgg ctggatctgg cggcatctgc cgggaaacgc gtggctgagg gcactgatct
    21961 cactggtgct cgtcttcgcc gtggtctacg tgctcttcca gtacgtcttc ccgtgggcgg
    22021 aacccctgct gccgttcaac gacgtcaccg tggacggcca gtgagcgccc ccggcggcgc
    22081 ccgccgcagc cgcgtgctcg tcgtcgacaa ctacgacagc ttcgtcttca acctcgtcca
    22141 gtacctgtac cagctgggtg ccgagtgcga ggtcctgcgc aacgacgagg tcgagctgaa
    22201 gcacgcgcag gacggcttcg acggcgtcct gctctcgccg ggccccggca ccccggagca
    22261 cgcgggcgtc tgcgtcgaga tggtgcggca ctgcgccgcc accggcgtgc ccgtcttcgg
    22321 ggtctgcctc ggcatgcagt cgatggcggt ggcgtacggc ggcgtggtgg accgcgcccc
    22381 cgagctgctg cacggcaaga cctcgctcgt gcgtcacgag ggcaagggcg tcttcgccgg
    22441 gctgccctcg cccttcaccg cgacccgcta ccactcgctc gccgccgagc ccgccaccgt
    22501 gccggccgag ctcgaggtga ccgcgcgcac ggaggacggc atcatcatgg gcctgcgcca
    22561 ccgtgaactg gccgtcgagg gcgtgcagtt ccacccggag tccgtgctga ccgagcacgg
    22621 gcacctgatg ctcgccaact ggctggtgga gtgcggcgac accggggccg tggagcgatc
    22681 gagcgggctc gccccggtgg tgggcagggc cacggcgtga cggccctgcg ccccgagcgc
    22741 gactcctccg gagcccctga cgacgagaac gtcgcgtacg agaacgtcgc gtacggggac
    22801 tccgctggtg atgcgcacgg gagcgcgcac ggggacgcga acggctacgc gcaggaggac
    22861 gccggcgcgt tcgccgcggc cgtcgacgac ttggccgacc ccctcaccga tccgctgccg
    22921 gggcagcacc cttcgccgtg gttccgcagc gcggccgcgg agccggtccc gccggaggcc
    22981 cacgaacagc cgcaggaaca gccgcaggaa caggagtggt acgaccccga ggggtacgtc
    23041 cgcgactggt acgggccgca ggagcctcag acgcagcgcc agatggcctc cccgcagcct
    23101 ccggcgcccg aaccgacgta cgaggagttg tacggcgcgt acgccccgga gaggcccacc
    23161 caggcgtacg aaccgatacc ggacgacgag acggtggggc tgcggacggc ggacccccgt
    23221 cgaatagccg aaccggagcg c
//
