LOCUS       NZ_CP022685            24629 bp    DNA     linear   CON 17-JAN-2024
DEFINITION  Streptomyces formicae strain KY5 chromosome, complete genome.
ACCESSION   NZ_CP022685
VERSION     NZ_CP022685.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces formicae
  ORGANISM  Streptomyces formicae
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9611874)
  AUTHORS   Holmes,N.A., Devine,R., Qin,Z., Seipke,R.F., Wilkinson,B. and
            Hutchings,M.I.
  TITLE     Complete Genome Sequence of Streptomyces formicae KY5, the
            formicamycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9611874)
  AUTHORS   Holmes,N.A., Devine,R., Qin,Z., Seipke,R.F., Wilkinson,B. and
            Hutchings,M.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2017) School of Biological Sciences, University of
            East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, United
            Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.0; Newbler v. 2.3
            Assembly Name                     :: KY5 Genome
            Expected Final Version            :: yes
            Genome Coverage                   :: 56.0x
            Sequencing Technology             :: PacBio; 454; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/17/2024 10:10:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,274
            CDSs (total)                      :: 8,185
            Genes (coding)                    :: 8,082
            CDSs (with protein)               :: 8,082
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 39 of 103
            Pseudo Genes (incomplete)         :: 77 of 103
            Pseudo Genes (internal stop)      :: 11 of 103
            Pseudo Genes (multiple problems)  :: 22 of 103
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:13:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3819304
            Orig. end                         :: 3843933
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022685.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Matthew Hutchings,
            University of East Anglia, UK.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24629
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="22"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..24629
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24629
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14629](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14629
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            428..1366
                     /locus_tag="KY5_RS16340"
                     /old_locus_tag="KY5_3234"
     CDS             428..1366
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019767105.1"
                     /locus_tag="KY5_RS16340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3234"
                     /product="RNA polymerase sigma factor SigF"
                     /protein_id="WP_098242938.1"
                     /transl_table=11
                     /translation="MSPRLDESRTDQATSTLPPTRSATEIPGPATEATPSTTAPEALEG
                     LQDLPEIPPYDEVGPLDARALSKTLFERLESLEEGTHEYAYVRNTLVELNLALVKFAAS
                     RFRSRSEPMEDIIQVGTIGLIKAIDRFELSRGVEFPTFAMPTIVGEIKRFFRDTSWSVR
                     VPRRLQELRLDLAKAGDELAQQFDRAPTVGELAERLGISNDEVVEGMAASNAYTASSLD
                     AQPEEDDSEGALADRIGYEDHGLEGIEYVESLKPLIAELPQRDRKILALRFVANMTQSE
                     IGDELGISQMHVSRLLSRTLVKLRKGLTVEE"
     gene            complement(1472..2173)
                     /locus_tag="KY5_RS16345"
                     /old_locus_tag="KY5_3235c"
     CDS             complement(1472..2173)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059223.1"
                     /locus_tag="KY5_RS16345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3235c"
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="WP_098242939.1"
                     /transl_table=11
                     /translation="MKTIGLIGGMSWESSAEYYRLLNELVRERLGGLHSARVVLYSLDF
                     AEIERLQVAGEWERAGEVLAVAGKGVEAAGADLVLICTNTMHKVADQVRDALSVPLLHL
                     GDATAAAVLRAGVRRVGLLGTAFTMEQDFYRERLAGHGLDVVVPDEAGRALVHRVIYEE
                     LCLGVVREASRAAYQEVIADLVERQGAEGVILGCTEIELLIGAEDSPVPVFPTTRLHAE
                     AAVEAALAEEV"
     gene            complement(2216..2560)
                     /locus_tag="KY5_RS16350"
                     /old_locus_tag="KY5_3236c"
     CDS             complement(2216..2560)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KY5_RS16350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KY5_3236c"
                     /product="hypothetical protein"
                     /protein_id="WP_098242940.1"
                     /transl_table=11
                     /translation="MLRRLLARLLPGTGTRRAPVAEAEAEAQAETVAVAEESPLRPGPS
                     APTRLPRSPYARDAAEGRPVDVSGAPLARPYYRAAERRLLQAERRLALALALEGVDYGP
                     AVIHGMTLPA"
     gene            complement(2561..2935)
                     /locus_tag="KY5_RS16355"
                     /old_locus_tag="KY5_3237c"
     CDS             complement(2561..2935)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019887355.1"
                     /locus_tag="KY5_RS16355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3237c"
                     /product="ATP-binding protein"
                     /protein_id="WP_098242941.1"
                     /transl_table=11
                     /translation="MRDPEIEFALLAVPKAVPELRRTLSEWHPHGPHPDVQLCVSELLS
                     NVIRHLGEGTPVTVRLTRAPGRIRVAVTDPDPRAWPLLRSAGSDDETGRGLALLDAVSL
                     RWGVEQGPDSKTVWCELGEG"
     gene            3051..3902
                     /locus_tag="KY5_RS16360"
                     /old_locus_tag="KY5_3238"
     CDS             3051..3902
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018551944.1"
                     /locus_tag="KY5_RS16360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3238"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_098242942.1"
                     /transl_table=11
                     /translation="MAARKDIDGSASVPAFYGKELRWKREAAGRTLQETVEGSYFGASY
                     LSEIERGQRRMPIELARHVDHFLKTDGFFERRCADVHKARRSKHAEYFAHIVDLEARAK
                     EIEEWNPTLIPGPLQLEPYIRAVIHASLPHDSEESIKAKVEARRERAWLFEDAKGPECW
                     IVLHESILRQPIIGEDEMAEQLAHILAVAERRRFIPQILPWNAGAHPFMMGTTWLMTFT
                     DAPPIMYTEGMYSGQIIDEPELVGQYTSAYGRLKAAAMPPKESLRMIERAAEEYGSGKC
                     GR"
     gene            3883..4098
                     /locus_tag="KY5_RS16365"
                     /old_locus_tag="KY5_3239"
     CDS             3883..4098
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018382523.1"
                     /locus_tag="KY5_RS16365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3239"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_098242943.1"
                     /transl_table=11
                     /translation="MASVDADLNITVWRKSSYSNGSGGLCLEVADGLPGVVPVRDSKVT
                     EGPAVVFPATAWAPFIGAVATGELPL"
     gene            4139..4756
                     /locus_tag="KY5_RS16370"
                     /old_locus_tag="KY5_3240"
     CDS             4139..4756
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983783.1"
                     /locus_tag="KY5_RS16370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3240"
                     /product="DUF5753 domain-containing protein"
                     /protein_id="WP_098242944.1"
                     /transl_table=11
                     /translation="MTRDERTEAAGANEWQDTWSQLQVGLQQKQNELAEFERRSTEFRY
                     LLPSMVTGLLATPEYVAASLSRFPGDHREAIAKKLERQAVLRDTSKRFTFILTEQAVRW
                     PYLPSPAMAVQLERLAAASLLPSVRLGVIPLSGHMPVAPLNTFTVYDDQIATVESSTGV
                     MVFRDRRDVAAYLNEFDGYEEYALFGEKARERLASWGRQFLS"
     misc_feature    4301..4303
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4862..4876)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.64"
                     /tool="antismash"
     misc_feature    complement(4882..4895)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.73"
                     /tool="antismash"
     gene            4988..5644
                     /locus_tag="KY5_RS16375"
                     /old_locus_tag="KY5_3241"
     CDS             4988..5644
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018549405.1"
                     /locus_tag="KY5_RS16375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3241"
                     /product="HD domain-containing protein"
                     /protein_id="WP_098242945.1"
                     /transl_table=11
                     /translation="MSDERRGLLAEKTPFPDDLDDRLHAQLTFLVEIDQLKTILRQSPL
                     AATDRRENDAEHSWHLAMMVVILAEHSDEPIDVGHTIQLVLLHDLVEIYAGDTPLYDSA
                     AGSDQHDREVAAADKLFSLLPADQARRVRLLWDEFEERRTPEAKFAKAMDRLQPLLLNW
                     MARGGTWRTPGVTADDVRARKAVIGEASASLWRAGRRLIDEGETRGWSRRATPQG"
     misc_feature    5009..5011
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5692..6690)
                     /locus_tag="KY5_RS16380"
                     /old_locus_tag="KY5_3242c"
     CDS             complement(5692..6690)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1206: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF013753.4"
                     /locus_tag="KY5_RS16380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3242c"
                     /product="transposase"
                     /protein_id="WP_234362746.1"
                     /transl_table=11
                     /translation="MEITLSYGAVATQPSRPAYAEGARLGAPAAIQVADRFHLWQGIGR
                     AVETCVAAHRECLNGLTAPTRTDAEASPNDSVCGGPDLDGRRAQRKKAAHALVHELLAQ
                     GHSRLAIARHLGWGLNTVLRYARAAAWQDTLRENRPRPSRLDPYKPYLERRFAAGCTSV
                     TRLHRELTAENAPVTYQMVRAYIATLRAAPPQAPPPPPTVRRVTGWLTRHPSTLKEDER
                     AALKDVLARCPELDIAAEHVRGFGEILAHRLGPTLPAWIEAVDASQLPGLTNFALHLLR
                     DLDAVTAGLTLHWSSGGTEGAVNAVNRIKKIKRQLYGRAGFELLRKMILLQ"
     gene            6796..7071
                     /locus_tag="KY5_RS42525"
                     /old_locus_tag="KY5_3243"
     CDS             6796..7071
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KY5_RS42525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KY5_3243"
                     /product="hypothetical protein"
                     /protein_id="WP_098242946.1"
                     /transl_table=11
                     /translation="MPPVDSRKVASPIDPEEVLGRGWAQDFALGLYLPDVSLTHRGEGA
                     ERQVQLWDEGGTSVAIVDYGEWWRDRAVTVYGERDLWAELVGAYSA"
     gene            complement(7207..7947)
                     /locus_tag="KY5_RS16390"
                     /old_locus_tag="KY5_3244c"
     CDS             complement(7207..7947)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024110.4"
                     /locus_tag="KY5_RS16390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3244c"
                     /product="ABC transporter permease"
                     /protein_id="WP_098242947.1"
                     /transl_table=11
                     /translation="MLRYAKLDTLCLIRSGYFLTFSVLFSAGFYLMFTVVASDAISDSP
                     DFARDYMLSMSVSGAFFGALNAAGIRLGAERGEGWARQILLTPLSGRAYLGAKALTAWL
                     ATLPATLVVFALGALVNDVSMPATDWLAALAVIWAASAVFVVAGLAVGLVAVGEAAQFT
                     CLGVFFPLALLGGLWFPLDDFPTTLRQAADYLPTRSLDQLATLVTPGDTDTPWLRPLLV
                     LVCWGVALGGVVLARSRAAVLARV"
     gene            complement(7949..8848)
                     /locus_tag="KY5_RS16395"
                     /old_locus_tag="KY5_3245c"
     CDS             complement(7949..8848)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018570550.1"
                     /locus_tag="KY5_RS16395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3245c"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_234362747.1"
                     /transl_table=11
                     /translation="MRDVDVVRRRGGARIRALSGVGLDVRRGERVALLGANGAGKTTLT
                     HVMLGLLRPSAGTVEVLGGPPEPALAAGELGAMLQESGLMRNVRVGELITLITELYGRR
                     TSEEVLAECGLGELSRRQVTQLSGGERQRLRLGLALAGLPRLLFLDEPTVALDVAARAR
                     FWEILNERARGGATVLFTTHYLHEAEQFADRVVVLRAGRIVADGTVDELRSAFTESRVS
                     FRTDEPLPDSMLRGLPGVRTTEERDDGTRVLTTTDSDATLAALYAKVGGAAGTVPRGLT
                     LTTASLEDAVATLLQEDH"
     misc_feature    8977..8992
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.15"
                     /tool="antismash"
     gene            9372..10004
                     /locus_tag="KY5_RS16400"
                     /old_locus_tag="KY5_3246"
     CDS             9372..10004
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013098.4"
                     /locus_tag="KY5_RS16400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3246"
                     /product="VOC family protein"
                     /protein_id="WP_098242949.1"
                     /transl_table=11
                     /translation="MIPKPVIINVPVDDVDAGIDFYEGFLGLRLARSLSPEQISFHAPV
                     SSDGILLTVNKRNFPGEGPTVMFAVEDMDAALASWKAAGGTVVAGPYDLPLPQKIRDEF
                     RDQFRDSPFYRGEAGDSMGRGASLHDAEGNRLGIVELSEWAHATFALGAYANPVSEEQL
                     KDQSIALARRVPASTQMFDAAGETAAAGETGSAGETGERHRSGGPTP"
     gene            10001..10927
                     /locus_tag="KY5_RS16405"
                     /old_locus_tag="KY5_3247"
     CDS             10001..10927
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="KY5_RS16405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3247"
                     /product="SagB/ThcOx family dehydrogenase"
                     /protein_id="WP_098242950.1"
                     /sec_met_domain="PF00881 (E-value: 2.1e-20, bitscore: 72.4,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEDSGLTEFSLGINAYRVLAPEARSVGVRTHQLRFDNLGAEPAA
                     ATGSRVAEEFLTASRLRAHDREGVLSAADYFGDSMVTTLAQLDDDPVATHQRTELPASV
                     AATMELGEALMRRRSVRRYSGDPIAAAELATVLRLADGLTAEADVELLRGGHETFRFRT
                     APSGGGLFPVALHVVALDVSGLDVGVYRYQPVRDVLVKEDGRAGVDRVLDAFTTPGTAI
                     AFDTAAALVVMVASPWRSMRKYGPRGLRFVLHESGAIAQNMHLAVTSLGLGSTDCASFV
                     DDELHAALGIDGVLRAAVHSVVLGRLE"
     gene            10924..12195
                     /locus_tag="KY5_RS16410"
                     /old_locus_tag="KY5_3248"
     CDS             10924..12195
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="KY5_RS16410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3248"
                     /product="coproporphyrinogen-III oxidase family protein"
                     /protein_id="WP_159072533.1"
                     /sec_met_domain="PF04055 (E-value: 1.4e-14, bitscore: 53.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGAPAGGTGAGRDLLVYLHIPFCRSKCHFCDWVTEVPTAELLLK
                     ETDQPRLRYIDALCHELTERGAALGAAGYRPTIIYWGGGTASILSLEEIAKVSAALHEA
                     FPLLGDPRAGLREATIECSPETLDPDKLAAFREVGFTRLSSGVQSFDDRRLRTLGRSHD
                     ADQARRIVQEAADAGFEDISIDLICGFPGQPPAETYDAVRTALDLPLTHVALYPYRPAH
                     GTVMRRQLGRGNRHIDRDEQKRGYAAGAELLVDAGFPEYAMSHFGSPDHLCHSDLTYFQ
                     LRSDWAGFGSGATSVLEGRYLSHARGRLLDYNRDPLAFEEDYELASAAIAPRLLYQSLT
                     TYEGARRDWWQERTGRPFDEVMDQRACRTLLDFFASVTTVERDEEGLRLPPDDVADAFI
                     ELQYLNAPRQGRTDLSVTAAALMG"
     gene            12217..13257
                     /locus_tag="KY5_RS16415"
                     /old_locus_tag="KY5_3249"
     CDS             12217..13257
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03882.1"
                     /locus_tag="KY5_RS16415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3249"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_098242952.1"
                     /transl_table=11
                     /translation="MSTRRTSRTVRIKSVYAVVPHDRNTVELRSGVWNPQSITLVDHSG
                     AGRLSTLVSGLDGTRDRAELAKEAGVTRTELEALIDHLDQLAVLEHGPSTALDAYLDRT
                     ASGRVEEATLPSLRVLGGTAAAQVAGLLGAHEQLTVTAPDAHAEQLRLLDECPLDVLED
                     GLAFERFVENFEDWRGCLLVHVADAVHPLRLAVLNRVALALGTPWIQAALDGPLLLVGP
                     TFVPDSTACFTCFETRVVMNLREGAAYQRYKKALAGPGAAAGEQGDGGTGVLSSLLASH
                     TALEALNMAVTGMTSTVGKVLGVYLPSMEMVYSEVLRLPGCPSCGTVPERDGTEVYFDV
                     RRWVDA"
     gene            13250..14629
                     /locus_tag="KY5_RS16420"
                     /old_locus_tag="KY5_3250"
     CDS             13250..14629
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="KY5_RS16420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3250"
                     /product="YcaO-like family protein"
                     /protein_id="WP_098242953.1"
                     /sec_met_domain="YcaO (E-value: 2.3e-36, bitscore: 125.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPELRTASGLRLVEPPDAQTRRLRRRMHAPLCGLMPQLGFLTRPR
                     YAPRLMVSGGDLTGVHVLRDQPRPKLGSYHIGGYGIRPHESHIRTLGEVVERYAGYVAA
                     VSGAFPVRFAPEADLADEPHFPVGSYVPYTQEQLASDGFPFRRPLPDEPLGWSRLTCLR
                     DGTDTWVPAQLTTVGYVVRDAEGEPWVQPAVTTGTAAHTDPHKAALGALQEMVQIDAAV
                     GHWYGGTRSVRIRPGTRCAALLRIVARHCHPLGGQPEFHLLPSADLPGFTVACLIREPG
                     GQIPAVAVGLGIDVRLESAMYKAFLEGVGVRALATWTSVQDHATGAAARSATGSAADDE
                     AIFDLESNVVLAASPQGARVVEERYGDCDEANADDLPPDPAVADPDACVRALVRAFHDT
                     GKRLYGGDLTTVDAAALGFVVARFWSPDLLTLPLPSAPTAAHPRFPAYGGFQRHAPHPF
                     P"
     gene            14607..15455
                     /locus_tag="KY5_RS16425"
                     /old_locus_tag="KY5_3251"
     CDS             14607..15455
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014566.4"
                     /locus_tag="KY5_RS16425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3251"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_098242954.1"
                     /sec_met_domain="Abi (E-value: 3.3e-09, bitscore: 35.9,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLIRSPELTGAVPADTRPLLAATVVVLGLASMTVAAHLHTRWAG
                     LRRLPMLGLHLGVCGLAVLGGAALLGTGVLRPVRDAGWAGLGAGLLLGPLVAYAATRAD
                     RSVTRWWGRRAGHSVRDDRPVALRSGHARPAGVAVAGAAPAGRRTGLIEARNDFAPTSA
                     DLRVRLPLLLAVAAAEELVYRGVLLGLALRAGPVLVVVGAVLGAQLVFAVSHVFFGWGQ
                     VLSKLPLAALCTGAVLVTGTVLPAVVGHALFNTWVWRYHRARPSAARPTRPAASAWGTA
                     R"
     gene            15452..16291
                     /locus_tag="KY5_RS16430"
                     /old_locus_tag="KY5_3252"
     CDS             15452..16291
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014566.4"
                     /locus_tag="KY5_RS16430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3252"
                     /product="CPBP family glutamic-type intramembrane protease"
                     /protein_id="WP_098242955.1"
                     /sec_met_domain="Abi (E-value: 1.2e-05, bitscore: 24.5,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPLRVLVLVAVVLLYYWLGKAVLFRAVRHLAAVTRIGPARWNT
                     AQRADVFELAAAGASHVVVVAALLAVTGIGPGMLVSGLARPELLGLGVLLGIGELAIGS
                     LICRALIEVKLSGGGRRRGPAVPANSARHVGVSGTGVRAPTPVRTRPREDRGLSLRSWL
                     GRSRGGWIRHHLTALKVLPLWAALGLTGVQVASEELVFRGIALTWLRDAGPFVALSTSI
                     VLFVVMQAFFMSTWQGAMFPLVGGVVMGVVHGLVFWAVPDVAPLVVAHVVFFVFAVI"
     gene            16307..17392
                     /locus_tag="KY5_RS16435"
                     /old_locus_tag="KY5_3253"
     CDS             16307..17392
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012517.4"
                     /locus_tag="KY5_RS16435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3253"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_098242956.1"
                     /transl_table=11
                     /translation="MEHGLSFLPDAEHHGLPAPEYFRTLLDLSRLADEAGLSHVKITEH
                     YLRAYGGYCPSPLAFLASVASVTTRVRLMTGCVLPVFHHPLRLASEAAMVDALSGGRLD
                     VGFARAYLPYEFEAFGVPMDGSRERFTATVDAVLRLWTEEKVTVDTPYFRFADATALPR
                     PVQSPHPPTWIAAVRSRSSFAWAGEQGHGLLVTPALTPLEEMADHIAVYRESFAQAGRP
                     EGRSRVLASLPLYVGRDDGEAFATADPLLAHYLRVWAESTDAWTTTVSTDYRGYTGMSR
                     AIRAMTPESFRTLGGAVVGGPHRVADRIRQIADVLDVDGFLWQVDFGAVGGAVARAGVE
                     RFCADVLPELADPAQRGGTGR"
     gene            complement(17580..18218)
                     /locus_tag="KY5_RS16440"
                     /old_locus_tag="KY5_3254c"
     CDS             complement(17580..18218)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.4"
                     /locus_tag="KY5_RS16440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3254c"
                     /product="response regulator transcription factor"
                     /protein_id="WP_159072534.1"
                     /transl_table=11
                     /translation="METDSAVRTRRREITVLVTEDDTLDRKAFTRLLQQEPGLRLVGDA
                     EARTDVVREAVRLAPDVVLVDLERTEKPLETVAALRRHCPCARSVILTTAGDVAQLRRA
                     VAAGTSAFVMKTVSIRGLRDVLRRVMAGERVLDPDLSVRALLTERCPLTPRECEVLGVS
                     RQSTTVAEIAATVSLSPGTVRNYLSRAITKTGARNRHEAAAAAARLGWI"
     misc_feature    18254..18267
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.57"
                     /tool="antismash"
     gene            complement(18353..19525)
                     /gene="hutI"
                     /locus_tag="KY5_RS16445"
                     /old_locus_tag="KY5_3255c"
     CDS             complement(18353..19525)
                     /EC_number="3.5.2.7"
                     /GO_function="GO:0050480 - imidazolonepropionase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006548 - histidine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hutI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961305.1"
                     /locus_tag="KY5_RS16445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3255c"
                     /product="imidazolonepropionase"
                     /protein_id="WP_098242958.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 2.1e-23, bitscore:
                     82.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTTLITNIASLVTNDPSQGDGSPIGLLTDAAVVLDGENVAWVGP
                     AAKAPAADTTYDAENRAVIPGFVDSHSHLVFAGDRTQEFNARMSGRSYSAGGIRTTVAA
                     TRAASDEELEANVVRYLAEALRQGTTTFETKSGYGLTTEHEARALRIASAHTDEVTYLG
                     AHIVSPDYAEDPAAYVELVTGEMLDACAPHARWIDVFCEKGAFDGDQARAILTAGKAKG
                     LHPRIHANQLSYGPGVQLAVELDAASADHCTHLTDADVDALAQGDTVATLLPGAEFSTR
                     AEWPDARRLLDAGATVALSTDCNPGSSFTSSVPFCIALAVRDMGMTPDEAIWSATAGGA
                     AALRRDDVGRIAVGARADLALLDAPSHVHLAYRPGVPLVTRVWRRGEPVA"
     gene            complement(19777..21138)
                     /locus_tag="KY5_RS16450"
                     /old_locus_tag="KY5_3256c"
     CDS             complement(19777..21138)
                     /EC_number="3.5.3.13"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016436358.1"
                     /locus_tag="KY5_RS16450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3256c"
                     /product="formimidoylglutamate deiminase"
                     /protein_id="WP_098247291.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 9.7e-39, bitscore:
                     132.4, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTERTDTYWLEHAWLGTHVEPGVAVDVTGDRITAVRTGAEAPPP
                     GAEVLRGLTLPGLANAHSHAFHRALRGTVQVGSGTFWTWREVMYSVADRLTPETYHALA
                     RAVYAEMALAGITTVGEFHYLHHGPGGTPYADPNAMGEALIQAAADAGVRITLLDTAYV
                     ASGLLDEERGKEPNHHQLRFSDGTTQAWAERASLLKDRDHARIGAAIHSVRAVPARQLG
                     TVAEWAGARGAPLHVHLSEQTAENDACLAVHGRTPTRLLADHGVLGARTTGVHNTHLTD
                     EDIALLGGTSTGTCMCPTTERDLADGIGPAVRLQRAGSPLSLGSDSHAVIDMLEEARAM
                     ELNERLRSHTRGHWTAAALLRAASADGHAALGWPDAGAIEQGALADLTTIALDSVRTAG
                     PVPRLGAETVLFAGTSADVRHTVAGGRHVVRGGVHALVPDVPSALAEAIAALRD"
     gene            complement(21135..22337)
                     /locus_tag="KY5_RS16455"
                     /old_locus_tag="KY5_3257c"
     CDS             complement(21135..22337)
                     /GO_function="GO:0016813 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds, in linear amidines
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524735.1"
                     /locus_tag="KY5_RS16455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3257c"
                     /product="allantoate amidohydrolase"
                     /protein_id="WP_098242959.1"
                     /transl_table=11
                     /translation="MWRDLKPIGRDTGSNGYRRYAWTGADADCRAWFKAQADTRGLTYE
                     LDRNGNQWAWLGDPRQGDAVVTGSHLDSVPDGGAFDGPLGVVSSFAALDELRHRGVEFT
                     RPLALVNFGDEEGARFGLACVGSRLAAGQLTIEAAHKLRDGDGVTLPQAMEAAGYDPYG
                     IGADPERLARIGAFVELHVEQGRALDLSGDPVGIASAIWPHGRWRFDFRGEANHAGTTR
                     LVDRRDPMLSYAETVLAARREAELAGAVATFGKISVEPNGVNAIPSLVRGWLDSRAPDQ
                     ESLDTVVTGIEKAAREYAERHGIDLDVVRESFTPVIEFEHALRDELGAILGAGTDRPLP
                     VLGTGAGHDAGILSGSIPTAMLFVRNPTGVSHSPAEHAAEDDCLAGVTALADVLEGLAC
                     R"
     gene            complement(22463..24121)
                     /gene="hutU"
                     /locus_tag="KY5_RS16460"
                     /old_locus_tag="KY5_3258c"
     CDS             complement(22463..24121)
                     /EC_number="4.2.1.49"
                     /GO_function="GO:0016153 - urocanate hydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006548 - histidine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hutU"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007382525.1"
                     /locus_tag="KY5_RS16460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_3258c"
                     /product="urocanate hydratase"
                     /protein_id="WP_098242960.1"
                     /transl_table=11
                     /translation="MSGPRPVRAPRGTELSALGWQQEAALRMLQNNLDPEVAEHPDKLV
                     VYGGTGKAARDWRSFDAMVRTLKTLKQDETMLVQSGRPVGVMQTHEWAPRVLIANSNLV
                     GDWANWEEFRRLEQLGLTMYGQMTAGSWIYIGTQGILQGTYETFAAVAAKRFNGTLAGT
                     ITLTAGLGGMGGAQPLAVTMNDGVAICIDVDPRAIERRIEHKYLDVRADSLAHALQLAT
                     EARDARRPLSIGLLGNAAELLPQMLAEGAPIDIVTDQTSAHDPLAYLPVGVDFDDMETL
                     ATKDPAGFTTRARESMARHVEAMVGFMDAGAEVFDYGNSIRGEAQLAGYDRAFAFPGFV
                     PAYIRPLFCEGKGPFRWAALSGEASDIHKTDKALLDLFPENESLHRWIKMAGERVHFQG
                     LPARICWLGQGERDKAGDMFNDMVGNGTLAAPLAIGRDHLDCGSVASPYRETEGMLDGS
                     DAIADWPLLNAMVNVASGASWVSLHHGGGVGMGRSIHAGQVSVADGTALAGEKIRRVLT
                     NDPGMGVIRHVDAGYDIAERVADERGVRVPMREGE"
     misc_feature    complement(24147..24161)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.49"
                     /tool="antismash"
ORIGIN
        1 agtcgacgac gaggcgtgcg tagccgtctg ccaggcagtt ttcgagtggt tcgcgcaaca
       61 gatcggccgt gtggtgatcc aactcacccg caggggtcac cacggcactc gtgcccgcct
      121 tccgcacttc gaccagaagc cggcccctgt gtgcgctgcc gaccgtcccg cggtccatgc
      181 cgtcactctc ttccgaccgt cgtggctgtt gatgacgccc ctgaacatta cgccttccgt
      241 acggtccggg gtacccgaac atcccccaga attcggacat ttcgccacgg aacgcacttg
      301 cgaccgagtt gccgaagcgg gtaggggtag aagagacagc aatcgacacg acggctttgg
      361 aggcgccgca caccgcagtg cacgtactgg catcggcagc catatgccga gaacgatgga
      421 ggacaccatg tcaccccggc tcgacgaatc gcgcactgac caagcgacgt cgacactccc
      481 gcctacccgc tccgcaaccg agatcccggg tcctgccacg gaggccacgc ccagcacgac
      541 ggcccccgaa gccctcgaag ggctccaaga ccttcccgag atcccgccgt acgacgaggt
      601 ggggccgctg gatgcgcggg ccctgtccaa gaccctcttc gagcgcctcg aatcgctcga
      661 ggaaggcact cacgaatacg cgtacgtccg caacaccctc gtcgaactca acctcgccct
      721 ggtgaagttc gccgcctccc ggttccgctc ccgcagcgag ccgatggagg acatcatcca
      781 ggtcggcacc atcggcctga tcaaggcgat cgaccgcttc gagctcagcc gcggcgtcga
      841 gttccccacc ttcgcgatgc cgacgatcgt cggcgagatc aagcgattct tccgcgacac
      901 cagctggtcg gtccgggtac cgcgccggtt gcaggaactc cgtctggacc tcgccaaggc
      961 gggcgacgaa ctcgcccagc agtttgatcg cgcccccacg gtgggcgagc tcgccgagcg
     1021 cctgggcatc tccaacgacg aggtcgtcga ggggatggcc gcgtccaacg cctacacggc
     1081 gagctccctg gacgcgcagc cggaggagga cgactccgag ggcgcgctcg cggatcgcat
     1141 cggctacgag gaccacggac tcgaaggcat cgagtacgtc gagtcgttga agcccctgat
     1201 cgccgaactg ccgcagcgcg accggaagat cctcgccctg cgcttcgtcg cgaacatgac
     1261 gcagtcggag ataggcgacg agctcggcat ctcccagatg cacgtctccc gcctgctctc
     1321 gcgcacgctc gtcaagctcc gcaaggggct gacggtcgag gagtgacgcg gcgtcacgcc
     1381 atttgtgagg gttcccgtgg ggcccgtcca ctgactcttc cggtcagaac ggacgggccc
     1441 cacacccatc tcctgaccgt tcgcggaacc ttcacacctc ctcggcgagt gccgcttcga
     1501 cggcggcctc ggcgtgcagc cgggtggtgg ggaacaccgg gaccgggctg tcctcggctc
     1561 cgatgagcag ctcgatctcg gtacacccga ggatcacgcc ctcggcaccc tgccgctcca
     1621 cgaggtccgc gatgacctct tgatacgcgg cccgcgacgc ctctctgacc actccgaggc
     1681 acaactcctc gtagatcacc cggtgcacga gggcgcgccc tgcctcgtcg gggacgacca
     1741 cgtcgagccc gtgcccggcg agccgctcgc ggtagaagtc ctgctccatg gtgaacgcgg
     1801 tcccgagcag ccccacacgt cgtacgcccg cgcgcaggac agcggcggcg gtggcgtccc
     1861 cgaggtgcag cagcggcacg gagagcgcgt cgcgcacctg gtcggccacc ttgtgcatgg
     1921 tgttggtgca gatgagcacg agatcggccc cggccgcctc aactcccttg cccgcgacgg
     1981 caagcacctc cccggcccgc tcccactccc ccgcgacctg gagccgctcg atctcggcga
     2041 agtccaggga gtacaacacg acccgcgccg agtgcagccc gccgagacgc tcccgcacga
     2101 gttcgttgag cagccggtag tactccgcgc tggactccca gctcatgccg ccgatgaggc
     2161 cgatggtctt catggggcca gggtcgcatc cgggtggtca cgtcaggcgg gcacgtcagg
     2221 cgggcagcgt catgccgtgg atgaccgccg ggccgtagtc cacgccttcc agggcgaggg
     2281 ccagcgccag ccgtcgctcc gcctggagaa ggcggcgttc ggcggcgcgg tagtaggggc
     2341 gggcgagagg agcaccgctc acgtcgaccg gacgaccctc ggcggcgtca cgtgcgtacg
     2401 ggctgcgcgg gaggcgggtc ggggcgctcg ggccggggcg tagcggggac tcctccgcta
     2461 ccgccaccgt ttccgcttgg gcttccgctt ccgcttccgc gacgggagcg cgacgggtgc
     2521 ccgtgccggg caggagccgg gcgaggaggc ggcgcagcac ctacccctcc cccagctcgc
     2581 accagacggt cttgctgtcg ggcccttgtt ccacgcccca gcggagcgag acggcgtcga
     2641 gcagggcgag tccgcgaccg gtctcgtcgt cgctgcccgc gctgcggagc aggggccagg
     2701 cgcggggatc gggatcggtg acggcgacgc ggatccggcc gggggcgcgg gtgaggcgga
     2761 cggtgacggg ggttccctcg ccgaggtggc ggatcacgtt gctgagcagc tcgctgacgc
     2821 agagctgtac gtcggggtgg gggccgtgcg ggtgccattc gctcagggtg cggcggagtt
     2881 cggggaccgc tttggggacg gcgaggaggg cgaactcgat ctcggggtct ctcatggcgg
     2941 ggtacgcctt ccgtgcgctc tgtgatggat tggtcacaca gtggcgtggg ggcggcgtag
     3001 cgtgacaggg gtttgggttc cacagtgcga ggtgtggaag gcggtcaact gtggcggcac
     3061 gcaaggacat cgacggctcg gcgagcgtcc ccgccttcta cggcaaggag ctgcgctgga
     3121 agcgggaggc ggcggggcgc acgcttcagg agacggtgga gggcagttac ttcggggcgt
     3181 cgtatctcag tgagatcgaa cgcggccagc ggcgtatgcc catcgaactg gcccggcacg
     3241 tggaccattt cctgaagact gacgggttct tcgagcggcg gtgcgcggat gtgcacaagg
     3301 cccggaggag caagcacgcc gagtacttcg cccacatcgt ggatctggaa gcgcgagcga
     3361 aggagattga ggagtggaac ccaaccctga tccccgggcc acttcagctg gagccgtaca
     3421 ttcgcgcggt tatccacgcc agtctccccc acgattccga ggaatcgatc aaagccaaag
     3481 tcgaggcgag acgcgagcga gcgtggctct tcgaagacgc gaaggggccc gagtgctgga
     3541 tcgtgctgca cgagtcgatc cttcggcaac cgatcatcgg ggaggacgag atggcggagc
     3601 agctcgccca tatcctcgcc gtcgccgagc gccgtcgttt cattccacag atccttccgt
     3661 ggaatgccgg agcgcacccc ttcatgatgg gcacgacctg gctcatgacc ttcactgatg
     3721 ccccgccgat catgtacacg gagggcatgt acagcgggca gatcatcgac gaaccggaac
     3781 tcgtggggca gtacacgagc gcgtacggtc gcctcaaagc cgcggcaatg ccgcccaagg
     3841 agtcgctgag gatgatcgag agagcagctg aggagtacgg aagtggcaag tgtggacgct
     3901 gacttgaaca tcaccgtctg gcgcaagagc agctacagca acggctccgg cggcctctgc
     3961 ctcgaagtcg ccgacggcct ccccggtgtc gtccccgtcc gggactccaa ggtcacggaa
     4021 gggcccgccg tcgtgttccc cgcgaccgcg tgggccccgt tcatcggcgc cgtcgcaacg
     4081 ggtgaactgc cgctctgacg ggcacattca gcacaccaca gggcaggagg gggcccgtat
     4141 gacgcgcgac gagcgtaccg aggcggcagg cgccaacgag tggcaggaca cctggtccca
     4201 gcttcaggtc ggtctgcaac agaagcagaa cgagctcgcc gagttcgagc gaaggtccac
     4261 cgagttccgg tacctactgc cgtccatggt cacgggcttg ttagcgaccc ccgagtacgt
     4321 cgccgcaagc ctttcccgtt ttcccggcga ccaccgcgag gccatagcga agaagctgga
     4381 gcgacaagcc gtcctccgtg acacgtcgaa gcggttcacc ttcattctga ccgagcaggc
     4441 cgtcaggtgg ccctatctcc cgtcccccgc catggcggtg cagttggagc ggctggcggc
     4501 tgccagcctc ctaccgagcg tgcgtctcgg agtgatcccg ctgagcggcc acatgcccgt
     4561 cgctcccttg aacacgttca cggtctatga cgatcagatt gcaacagtgg agtcttctac
     4621 cggagtcatg gtgttccggg accgccgcga tgtcgccgca tatctgaacg agttcgacgg
     4681 gtacgaggag tacgccctgt tcggggagaa ggcacgagaa cgactggcct catggggtcg
     4741 ccagttcctt tcctgatcgt ctacccaagg cgcgcgagga acggacccgc ttcaccggaa
     4801 gcctcggcgc acatattgaa ggaggccctc cgtgctcttg gatggtgaga aatgggctct
     4861 ggcacagatc ttggggagtg gtcgcggagg gtcacccaag ccggtcgtcg cctgaagcgg
     4921 tgttcgtctg ggggttgtgg accatgattc gccctgcgag ccggaccgtg catgccacga
     4981 taagcccatg agtgatgagc gccgcggttt acttgccgag aagacaccat tccccgacga
     5041 cctcgatgat cgcctgcatg cccaactcac ctttctcgtc gagatcgacc agctcaagac
     5101 catcctccgt cagtctcccc ttgctgcgac ggaccgccgt gagaacgacg cggagcactc
     5161 ctggcacctg gcgatgatgg tggtgatcct cgccgaacac tccgacgaac ccatcgacgt
     5221 aggtcacacc attcagctcg tcctcctgca cgatctggtg gagatctacg ccggtgacac
     5281 ccctctgtac gacagtgccg cggggagcga tcagcacgac cgggaagtag cggctgccga
     5341 caagctcttc agcttgcttc cggcggatca ggctcggcgc gtgcggcttc tgtgggacga
     5401 attcgaggaa cgtcgcactc ccgaagccaa attcgccaag gcgatggacc ggctgcagcc
     5461 actccttctc aactggatgg cgcgcggtgg tacgtggcgt actccgggcg tcaccgctga
     5521 cgatgtccgg gcccgcaagg cagtgatcgg tgaggcatcc gcctccctgt ggagggctgg
     5581 gcgacgtctt atcgacgagg gtgagacgcg cggctggtcg cgacgggcca cgccccaggg
     5641 gtgacgggtg ccgcgtcggc tgctctgccc tggagaaacg tgtcacggcg gtcactgaag
     5701 caggatcatc ttgcggagta gttcgaatcc ggctcgtccg tagagctgcc ttttgatctt
     5761 cttgatgcgg ttcacggcgt tcacggcgcc ttccgtgccg ccggagctcc agtgcaaggt
     5821 gagaccggcg gtcaccgcat cgaggtctcg gagcaggtgg agggcgaagt tcgtgaggcc
     5881 gggcagctgg ctggcatcga cggcctcgat ccatgcgggg agcgtgggac ccagccggtg
     5941 agccaggatc tcaccgaaac cgcggacatg ttcggccgcg atatccagtt caggacagcg
     6001 agccaggacg tccttcaacg cggcgcgctc gtcctccttc agggttgagg ggtggcgggt
     6061 gagccagccg gtgacccgcc tcacggtcgg tggcgggggc ggcgcctgcg gcggtgcggc
     6121 gcgcagggtg gcaatgtagg cgcggaccat ctgataggtg acgggggcgt tctcggcggt
     6181 cagttcgcga tgcaggcgag tgacgctcgt gcagcctgcg gcgaaccggc gctccagata
     6241 gggcttgtag gggtccaggc ggctgggccg gggtcggttc tcccggaggg tgtcctgcca
     6301 ggcggcggca cgtgcgtagc gcagcacggt gttgagtccc cagcccagat gccgggcgat
     6361 cgccaggcgg gagtggccct gggcgagcag ctcgtggacc aaggcgtgcg cggccttctt
     6421 gcgctgcgcc cgccggccat caaggtccgg tccgccgcac accgagtcat tgggcgacgc
     6481 ctcagcgtcc gttcgtgttg gcgctgtgag tccgttcagg cactcgcggt gggcggcgac
     6541 acatgtttcc acggctcggc cgatgccctg ccacaggtgg aaccggtcgg cgacctggat
     6601 cgcggcggga gcgcccagtc gcgcgccctc ggcataggcc ggcctggagg gctgggtggc
     6661 gaccgctccg tacgacaggg tgatctccac ggcagccgta cgaagctgcg ggtgcgtgga
     6721 ggggtcgcgt caggtcggtt cgtcggcggg gcctgttaca tgtgggttcg gagccatcgc
     6781 cccaagaatc agctcgtgcc cccggtcgac agccggaagg ttgcctcgcc catcgaccct
     6841 gaagaagtcc tggggcgtgg ctgggctcag gacttcgcgc tggggctgta tctgccggac
     6901 gtgtccctga ctcatcgtgg agaaggcgcg gagaggcagg tgcagctctg ggacgaggga
     6961 ggaacgtcgg tcgcgatcgt cgattacggc gaatggtggc gcgaccgagc ggtgaccgtc
     7021 tacggagagc gggacctctg ggccgagctg gtcggggcgt acagcgcgta gtgccttgcc
     7081 gggcggccgg actaccggcg gttcgggctc acgtacgacg aggccggtga gcacctctgg
     7141 ctcgatcgtc cggaaggcat cctgcggtcc agggcgactt ggtgacccgc ccctcacacc
     7201 cgcccctcac acccgcgcca acaccgccgc ccgtgaccgc gcaagaacca cccctcccag
     7261 ggccaccccc cagcacacca gcaccagaag cgggcgcagc cagggtgtgt ccgtgtcgcc
     7321 cggggtgacc agcgtggcca gttggtccag ggagcgggtc gggaggtagt cggctgcctg
     7381 gcgcaaagtc gtggggaagt cgtccagggg gaaccacagg ccgcccagga gtgccagggg
     7441 gaagaagacg ccgaggcagg tgaactgcgc ggcctcgccc accgcgacga ggcccacggc
     7501 caggcccgcc accacgaaga ccgcgctggc ggcccagatc acggcgagcg cggcgagcca
     7561 gtcggtcgcg ggcatcgaca cgtcgttgac cagtgcgcca agcgcgaaga ccaccagggt
     7621 cgcgggcagg gtggccagcc aggcggtgag ggccttggcg cccaggtagg cgcggcccga
     7681 gagcggggtc agcaggatct ggcgggccca gccctcgccg cgctccgcgc cgaggcggat
     7741 gcccgccgcg ttgagcgcgc cgaagaacgc gcccgacacc gacatggaga gcatgtagtc
     7801 gcgggcgaag tccgggctgt ccgagatggc gtcggacgcc accacggtga acatcaggta
     7861 gaagcccgcg gagaagagca ccgagaaggt caggaagtag ccgctgcgga tgaggcagag
     7921 ggtgtccagt ttcgcgtagc gcagcatgtc agtggtcctc ctggaggagg gtggcgacgg
     7981 cgtcctccag ggatgccgtg gtgagggtga ggccgcgcgg cacggtcccg gcggcgccgc
     8041 cgaccttggc gtagagcgcg gcgagcgtcg cgtcgctgtc ggtggtggtg aggacgcggg
     8101 tgccgtcgtc gcgttcctcg gtcgtccgca cgccgggcag gccgcgcagc atgctgtcgg
     8161 gcagcggctc gtccgtacgg aaggagacgc ggctctcggt gaaggccgag cgcagctcgt
     8221 cgaccgtgcc gtcggcgacg atccggcccg ccctgagcac cacgacgcgg tcggcgaact
     8281 gctcggcctc gtgcaggtag tgggtggtga agagcaccgt cgcgccgccc ctggcgcgct
     8341 cgttgaggat ctcccagaag cgggcgcgcg ccgccacgtc gagggcgacg gtgggctcgt
     8401 ccaggaagag cagccggggc agtcccgcaa gggcgaggcc gaggcgcagg cgctgccgct
     8461 cgcctcccga cagctgcgtc acctgtcgtc ggctcaactc gccgagtccg cactcggcca
     8521 ggacctcttc gctggtgcgg cgcccgtaca actcggtgat gagggtgatc agttcgccta
     8581 cgcggacatt gcgcatcagg cccgactcct ggagcatcgc gccgagttcg cccgccgcga
     8641 gcgcgggttc cggcgggccg ccgagcacct cgacggtgcc cgcgctcggc cgcagcagac
     8701 ccagcatgac gtgggtcagc gtcgtcttgc ccgcgccgtt ggcgccgagc agcgccaccc
     8761 gctcaccgcg ccgcacgtcg aggccgaccc cggaaagggc ccgtatccgg gcgccgccgc
     8821 gccgccggac gacatcgaca tcacgcacgc gcaccagaat ctccgccgcc gtcatcctcg
     8881 cccctcgccc ctagcccctc gcctgattcc gacgccatcg agccgcgcca gagtagcagt
     8941 agatcgtttt ggggaaaggg gtcgcaatcg ttcagcaatg acatttgtca ccggttatcg
     9001 atgacgcggc ctggtgaatt ccgcgttgac aggcgagttc cggccttctg atacttgggc
     9061 acttgtgcgg gacattcacc attcacgttc cgcgcttcat cgataagtga tccgggaggt
     9121 gaattcactt gaagatcgag agcgtgatcg tagtcgagca ccgcagttcg gccctccagc
     9181 cgggcctcgt gtcggcggcc gacggcgccg ccttcggcgt cgtggtgccc ggggcgtcct
     9241 cctgctgcgc aggttgtacg tccacgtcct gcggagccgt agtgcgcccg ctggcgtaag
     9301 cagaaggggt gccgggcgcg cgcggcccgg cacctccagg ggcggcacgg cgccgcagga
     9361 agaagagaga gatgattccc aaacctgtca tcatcaatgt tcctgtcgac gacgtcgacg
     9421 ccggaatcga tttctacgag gggtttctcg ggctccggct cgcccgctcg ctctcgcccg
     9481 agcagatttc tttccacgca cccgtttcga gcgacggcat actgctcacc gtcaataagc
     9541 ggaatttccc cggcgagggc ccgaccgtga tgttcgccgt cgaggacatg gacgcggcac
     9601 tggcgtcctg gaaagcggcg ggcggcaccg tcgtggccgg accctatgac cttccgctgc
     9661 cccagaagat ccgtgacgaa ttccgtgatc aattccggga cagccccttc taccggggtg
     9721 aggcgggcga ctccatgggg cggggcgcga gcctgcacga cgccgagggc aaccgcctgg
     9781 ggatcgtcga gctcagcgag tgggcgcacg cgacgttcgc cctcggcgcg tacgcgaacc
     9841 cggtcagcga ggagcagttg aaggaccagt cgatcgcgct cgcccggcgg gtgcccgcca
     9901 gcacccagat gttcgacgcg gcgggcgaga cggccgccgc gggcgagacg ggctctgcgg
     9961 gcgagacggg cgagcggcac cggtcaggag ggcccacccc atgaacgagg attccggtct
    10021 caccgagttc agcctcggca tcaacgccta ccgcgtactg gcgcccgagg cacggtcggt
    10081 gggcgtgcgc acgcaccagc tccgcttcga caacctgggc gccgaacccg ccgccgcgac
    10141 cggcagccgc gtggccgagg agttcctgac ggccagccga ctgcgggccc acgaccgcga
    10201 gggcgtcctg tccgccgccg actacttcgg cgactccatg gtcaccacgc tcgcccagct
    10261 cgacgacgac ccggtcgcca cccaccagcg gaccgagctg cccgcgtccg tcgcggccac
    10321 gatggagctc ggtgaggccc tgatgcgccg ccgcagcgta cgccgctaca gcggggaccc
    10381 catcgccgcc gccgaactcg ccaccgtcct gcggctcgcc gacgggctca cggcggaggc
    10441 cgacgtggag ctcctgcgcg gcggccacga gacgttccgc ttccgtacgg cgcccagcgg
    10501 gggcggcctg ttcccggtcg ccctgcacgt cgtcgcgctc gacgtgagcg gactcgacgt
    10561 gggcgtctac cgctaccagc cggtccgcga cgtcctggtc aaggaggacg gcagggcggg
    10621 cgtcgaccgg gtgctcgacg ccttcaccac gccgggcacc gcgatcgcct tcgacaccgc
    10681 cgcggcgctg gtggtcatgg tcgcgagccc ctggcggagc atgcgcaagt acgggccgag
    10741 gggcctgcgc ttcgtgctgc acgagtccgg cgccatcgcg cagaacatgc acctcgcggt
    10801 gacctcgctc ggcctcggct cgaccgactg cgccagcttc gtcgacgacg agctgcacgc
    10861 ggcgctcggc atcgacgggg tgctgcgggc ggccgtgcac tcggtggtcc tggggaggct
    10921 ggagtgacgg gcgcccccgc cggagggacc ggcgccggcc gggacctcct cgtctacctg
    10981 cacatcccgt tctgccgctc caagtgccac ttctgcgact gggtcacgga ggtgccgacc
    11041 gccgagctgc tgctcaagga gaccgaccag ccgcggcttc gctacatcga cgcgctctgc
    11101 cacgaactca ccgagcgcgg cgccgcgttg ggcgccgcgg gctaccggcc gaccatcatc
    11161 tactggggcg gcggcaccgc gtccatcctc tccctcgaag agatcgcgaa ggtgagcgcg
    11221 gccctgcacg aggcgttccc gctgctcggc gacccgcgtg ccggactgcg cgaggcgacg
    11281 atcgagtgca gccccgagac cctcgacccc gacaagctcg cggcgttccg cgaggtcggc
    11341 ttcacccggc tgagcagcgg cgtgcagtcc ttcgacgacc ggcggctgcg caccctgggc
    11401 cgcagccacg acgcggacca ggcacggcgc atcgtccagg aggcggccga cgccgggttc
    11461 gaggacatca gcatcgacct gatctgcggc ttccccgggc agccgcccgc cgagacgtac
    11521 gacgccgtgc gcaccgcgct cgacctgccg ctcacccacg tcgcgctgta cccctaccgg
    11581 cccgcgcacg gcacggtgat gcgccgccaa ctgggcaggg gcaaccggca catcgaccgc
    11641 gacgagcaga agcggggcta cgccgcgggg gccgagctgc tcgtcgacgc gggcttcccg
    11701 gagtacgcga tgagccactt cggctccccc gaccacctct gccacagcga cctgacctac
    11761 ttccagctcc gctccgactg ggccgggttc ggctccggcg ccacctcggt gctcgaaggc
    11821 cgctacctct cgcacgcccg gggccgcctc ctcgactaca accgcgaccc gctcgccttc
    11881 gaggaggact acgagctggc ctcggccgcc atcgcgccgc gcctgctcta ccagtccctg
    11941 acgacgtacg agggcgcgcg ccgcgactgg tggcaggagc gcaccgggcg ccccttcgac
    12001 gaggtgatgg accagcgcgc ctgccgcacc ctcctcgact tcttcgcctc cgtcaccacc
    12061 gtggagcgcg acgaggaagg gctgcggctg cctcccgacg acgtcgccga cgccttcatc
    12121 gaactgcagt acctgaacgc gccccggcag gggcgcaccg atctgtccgt gactgccgcc
    12181 gcactcatgg gctgacccga ccgggaggag aagtccgtgt ccacgcgacg caccagccgc
    12241 accgtgcgca tcaagtccgt ctacgcggtg gtcccgcacg acaggaacac ggtggaactg
    12301 cgctccggcg tatggaatcc acagtcgatc acgctcgtcg accacagcgg cgccggccgc
    12361 ctcagcaccc tcgtcagcgg tctcgacggc accagggacc gcgccgagct cgccaaggag
    12421 gccggggtca ccaggaccga actggaggcg ctgatcgacc acttggacca gctcgccgta
    12481 ctcgaacacg gcccctccac cgcgctcgac gcctacctcg accgcacggc gagcgggcgc
    12541 gtcgaggagg ccaccctgcc gtccctgcgc gtcctgggcg gcacggccgc cgcgcaggtg
    12601 gcggggctgc tcggcgcgca cgaacagctc accgtcaccg cgcccgacgc gcacgccgag
    12661 cagctgcggc tcctggacga gtgcccgctg gacgtcctgg aggacggcct cgccttcgag
    12721 cggttcgtgg agaatttcga ggactggcgg ggctgtctgc tcgtgcacgt cgccgacgcc
    12781 gtgcacccgc tgcgcctcgc cgtcctgaac cgggtcgcgc tcgcgctcgg caccccctgg
    12841 atccaggccg cgctcgacgg cccgctgctc ctggtgggac cgacgttcgt gccggacagc
    12901 acggcctgct tcacctgctt cgagacccgc gtggtgatga acctccgcga gggcgccgcc
    12961 taccagcgct acaagaaggc cctggcgggc cccggcgccg cggccgggga gcagggcgac
    13021 ggcggcaccg gcgtgctctc ctcgctgctc gcctcgcaca ccgcgctcga agcgctgaac
    13081 atggcggtca ccggcatgac cagcacggtc ggcaaggtgc tcggcgtcta tctgccgtcg
    13141 atggagatgg tctactccga ggtgctcagg ctgcccggct gcccgtcctg cggcacggtg
    13201 cccgaacgcg acggcaccga ggtctacttc gacgtcaggc ggtgggtcga tgcctgagct
    13261 gcgcaccgcg tcgggactcc gcctggtcga gccgcccgac gcgcagaccc gccggctgcg
    13321 ccgccgcatg cacgcgccgc tgtgcggcct catgccccag ctcggcttcc tcacccggcc
    13381 ccggtacgcg ccccgcctca tggtctcggg cggcgacctc accggcgtcc acgtcctgcg
    13441 cgaccagccg cgccccaagc tgggcagcta ccacatcggc ggctacggga tacgtcccca
    13501 cgagtcgcac atccgcaccc tgggcgaggt ggtggagcgc tacgccgggt acgtcgccgc
    13561 cgtgagcggc gccttccccg tgcggttcgc ccccgaggcc gacctcgcgg acgagccgca
    13621 cttcccggtc ggctcctacg tcccgtacac ccaggagcag ttggcgagcg acggcttccc
    13681 cttccggcgt cctctccccg acgaaccgct gggctggagc cgcctcacct gtctgcgcga
    13741 cggcaccgac acctgggtgc ccgcgcagct cacgacggtc ggctacgtgg tccgcgacgc
    13801 cgagggcgaa ccctgggtgc agcccgccgt caccaccggc accgcggcgc acaccgaccc
    13861 gcacaaggcg gcgctcggcg cgctccagga gatggtgcag atcgacgcgg ccgtcgggca
    13921 ctggtacggc gggaccaggt cggtgcgcat ccggccaggg acacgctgcg cggcgctgct
    13981 caggatcgtc gccaggcact gccatcccct gggcgggcag cccgagttcc acctgctgcc
    14041 cagcgccgac ctgcccggct tcaccgtcgc ctgcctgatc cgcgagccgg gcgggcagat
    14101 ccccgcggtc gccgtcggcc tcggcatcga cgtacgcctg gagtccgcca tgtacaaggc
    14161 gttcctggaa ggcgtcgggg tgcgggcgct cgcgacctgg acgagcgtcc aggaccacgc
    14221 cacgggggcg gccgcacgct ccgccacggg gtccgccgcc gacgacgagg cgatcttcga
    14281 cctggagagc aacgtcgtcc tcgccgcgtc cccccagggc gcccgcgtgg tcgaggagcg
    14341 ctacggcgac tgcgacgagg cgaacgccga cgacctgccg ccggatcctg cggtcgcgga
    14401 tcccgacgcc tgcgtgcgcg ctctcgtgcg ggccttccac gacaccggca agcgcctcta
    14461 cggcggcgat ctgaccaccg tggacgccgc cgcactcggc ttcgtggtcg cccggttctg
    14521 gagccccgac ctgctcaccc tgccgctgcc cagcgccccg acggcggccc atccccggtt
    14581 cccggcctac ggagggttcc agcggcatgc ccctcatccg ttcccctgaa ctgaccggcg
    14641 ccgtaccggc cgacacccgt ccgctcctcg ccgccaccgt cgtcgtcctc ggcctcgcgt
    14701 cgatgaccgt cgccgcccat ctgcacaccc gctgggcggg cctgcgacgg ctgccgatgc
    14761 tcggtctgca cctcggcgtc tgcggcctcg ccgtgctcgg cggcgccgcg ctgctcggca
    14821 cgggcgtgct gcggccggtg cgggacgcgg gctgggcggg tctcggggcg gggctgctgc
    14881 tcggtccgct cgtggcgtac gcggccaccc gcgccgaccg gtcggtgacg cggtggtggg
    14941 ggcggcgggc cgggcactcc gtgcgcgacg accgtccggt ggcactgcgt tcggggcacg
    15001 cgcggcccgc cggggtcgcc gtcgcggggg ccgcgcccgc cgggcggcgc accgggctca
    15061 tcgaggcgcg caacgacttc gcgccgacct ccgcggacct gcgggtacgg ctcccgctgc
    15121 tgctcgcggt ggcggcggcc gaggaactgg tctaccgggg cgtgctgttg ggcctcgcgc
    15181 tgcgggcggg gcccgtgctc gtcgtggtcg gcgcggtgct cggcgcacag ctcgtcttcg
    15241 ccgtctccca cgtgttcttc ggctggggcc aggtcctctc caagctgccg ctggccgcgc
    15301 tgtgcacggg cgcggtgctg gtcaccggca cggtgctgcc cgccgtcgtc gggcacgccc
    15361 tcttcaacac ctgggtctgg cgctaccacc gggcgcggcc ttcggcggcc cgcccgaccc
    15421 gccccgccgc ctcggcctgg gggacggccc gatgagtacg ccgctgcgcg tcctcgtcct
    15481 ggtcgcggtc gtgctcctct actactggct cggcaaggcc gtgctgttcc gcgccgtgcg
    15541 gcacctcgcg gccgtgaccc ggatcggccc ggcccgctgg aacacggcgc agcgcgccga
    15601 cgtcttcgag ctggccgcgg cgggggccag ccacgtcgtg gtggtggcgg cgctcctggc
    15661 ggtgaccggg atcgggcccg gcatgctggt ctcgggcctc gcccggcccg agctgctcgg
    15721 tctcggggtg ctgctcggca tcggtgaact ggccatcggg tcgctgatct gccgggcgct
    15781 gatcgaggtg aaactgtcgg gaggcgggcg gcggcggggg cctgccgtgc ccgccaactc
    15841 cgcacggcac gtgggtgttt caggaacggg cgtacgcgcg cccacccccg tccgcacacg
    15901 gccccgcgag gaccgcgggc tctccctgcg ctcctggctc gggcgctcgc gcggcgggtg
    15961 gatccggcat cacctcaccg ccctgaaggt gcttccgctg tgggcggcgc tcggcctgac
    16021 cggggtccag gtcgcctccg aggagctggt gttccggggc atcgccctca cctggctgcg
    16081 cgacgcgggg cccttcgtcg cgctctccac ctccatcgtg ctgttcgtcg tcatgcaggc
    16141 gttcttcatg tccacctggc agggcgcgat gttccccctg gtgggcggcg tggtgatggg
    16201 ggtcgtgcac ggcctggtgt tctgggcggt gccggacgtg gcgccgctcg tggtggccca
    16261 tgtcgtgttc ttcgtgttcg ccgtcatctg aaggagtacc cacgtcatgg agcacggcct
    16321 gtcgttcctg cccgatgccg aacaccacgg gctgcccgcg cccgagtact tccggacgct
    16381 gctcgacctc agcaggctcg ccgacgaggc ggggctcagc cacgtgaaga tcaccgagca
    16441 ctatctgcgc gcctacggcg gctactgtcc gagcccgctg gcgttcctgg cgagcgtcgc
    16501 ctccgtcacg acgcgggtgc ggctgatgac cggctgcgtg ctgccggtct tccaccatcc
    16561 gctgcggctc gcgtcggagg cggcgatggt ggacgcgctc agcggggggc ggctcgacgt
    16621 ggggttcgcg cgggcgtatc tcccttacga gttcgaggcg ttcggggtgc cgatggacgg
    16681 cagccgcgag cggttcaccg ccacggtgga cgcggtcctg cgcctgtgga ccgaggagaa
    16741 ggtcacggtc gacacgccgt acttccggtt cgccgacgcg acggcgctgc cccgccccgt
    16801 gcagtccccg cacccgccga cctggatcgc ggccgtccgc tcccggtcga gcttcgcgtg
    16861 ggcgggcgag caggggcacg ggctcctggt gactccggcg ctgacgccgc tggaggagat
    16921 ggccgaccac atcgcggtgt accgggagag cttcgcgcag gccgggcgcc cggaaggccg
    16981 ctcgcgggtg ctcgcgagcc tgccgctgta cgtcggcagg gacgacggcg aggcgttcgc
    17041 gacggcggac ccgctgctcg cccactacct gcgcgtgtgg gccgagtcga cggacgcgtg
    17101 gacgacgacg gtctccacgg actaccgcgg ctacaccggc atgagccggg cgatccgcgc
    17161 gatgaccccc gagtcgttcc gcaccctcgg cggcgcggtc gtgggcggcc cgcaccgggt
    17221 cgccgaccgc atccggcaga tcgccgacgt cctcgacgtg gacggcttcc tgtggcaggt
    17281 ggacttcggc gcggtcggcg gggcggtggc ccgtgcgggc gtggagcggt tctgtgcgga
    17341 cgtcctgccg gaactggccg atcccgcgca gcggggcgga accggccggt gaggcttggc
    17401 gggcccgccg cgcggcgagc gcccagatcc ggcccggccg gacggccacc gcagccgact
    17461 cgccgctcga cgcgcagcag ttgcgcgtac gtcctggccg agctggccgg accggttgga
    17521 gcggacgggt ggcctgaccg gccggtgacg cccgacggtc cccgccgccc cgcgaccgct
    17581 cagatccagc ccagccgagc cgccgccgca gccgcctcgt ggcggttgcg cgcgcccgtc
    17641 ttcgtgatcg ctcgtgacag gtagttgcgc accgtgcccg gagacaggga gacggtggcc
    17701 gctatctcgg ccaccgtcgt cgactgtcgt gatacgccca ggacttcgca ttcgcgcggg
    17761 gtgagcggac atcgttcggt gagcagggcg cggacggaca ggtccgggtc gagtacccgc
    17821 tcgcccgcca tgacccgcct gaggacgtcc cgcaggcccc tgatcgagac ggtcttcatg
    17881 acgaaggcgg acgtccccgc cgccaccgcc ctgcgcagct gcgcgacgtc ccccgccgtg
    17941 gtcaggatga cgctgcgcgc gcaggggcag tgcctgcgga gcgccgccac cgtctccagg
    18001 ggcttctcgg tacgttccag gtcgaccagg accacgtccg gtgccagccg gacggcctcg
    18061 cgcaccacgt ccgtcctggc ctcggcgtcg ccgaccaggc gcagcccggg ctcctgttga
    18121 agaaggcgcg tgaacgcctt cctgtcgagc gtgtcgtcct ccgtcaccag cacggtgatc
    18181 tcacggcgcc gggtcctcac agcactgtcg gtctccactc ctgcctcccc cgtaagacat
    18241 ccgcggacct ccacggacat ccgttccagg ctgccacgcc tggccggttg tgcgccccat
    18301 gcgattccgg ccaagggccg tggccccagg cgccccagag ctcactcccg tgtcaggcca
    18361 ccggctcccc gcgccgccac acgcgcgtca ccagcggcac gccgggacgg taggcgaggt
    18421 gcacgtgact cggggcgtcg agaagggcca ggtcggcgcg ggcgcccacc gcgatccggc
    18481 cgacgtcgtc gcggcgcagg gccgccgcgc cgcccgccgt ggccgaccag atcgcctcgt
    18541 cgggggtcat gcccatgtcc cgtacggcga gggcgatgca gaaggggacc gaggaggtga
    18601 aggacgaacc cgggttgcag tccgtggaga gcgcgaccgt ggcgcccgcg tcgaggaggc
    18661 ggcgggcgtc cggccactcg gcccgggtgg agaactcggc gccggggagc agggtggcca
    18721 ccgtgtcgcc ctgcgcgagg gcgtcgacgt cggcgtccgt caggtgcgtg cagtggtccg
    18781 ccgatgccgc gtccagctcc accgcgagct ggacgccagg accgtacgac agctggttcg
    18841 cgtggatgcg ggggtgcagg cccttcgcct tgcccgccgt caggatcgcg cgggcctggt
    18901 cgccgtcgaa ggcgcccttc tcgcagaaga cgtcgatcca gcgggcgtgc ggggcacagg
    18961 cgtcgagcat ctcgcccgtc accagctcca cgtacgccgc cgggtcctcc gcgtagtcgg
    19021 gggagacgat gtgcgcgccg aggtaggtga cctcgtccgt gtgcgccgac gcgatgcgca
    19081 gggcccgcgc ctcgtgctcc gtcgtgaggc cgtagcccga cttcgtctcg aacgtggtcg
    19141 tgccctggcg cagcgcctcg gcgaggtagc ggacgacgtt ggcctcgagt tcctcgtcgc
    19201 tcgccgcgcg cgtcgccgcc accgtcgtgc ggatgccgcc cgccgagtaa ctccggcccg
    19261 acatacgggc gttgaactcc tgcgtgcgat cgcccgcgaa gaccaggtgg gagtgggagt
    19321 cgacgaagcc ggggatcacg gcccggttct ccgcgtcgta cgtcgtgtcg gcggcgggcg
    19381 ccttcgcggc ggggccgacc caggcgacgt tctcgccgtc caggacgacg gccgcgtccg
    19441 tcaggaggcc gatggggctt ccgtccccct gggaggggtc gttggtgacg aggctggcga
    19501 tgttggtgat gagggtggtg ggcatgggtt cctctgcggg tgggtggggg cgggcgtctt
    19561 gcctccggcg gttctttccc cgatcccgcc ccttcccgaa aacttccggc tccgccggac
    19621 ggggctcggt cgatcaccgg cttcgccgag ttcgtcctca agcgccggac gggctatgtg
    19681 ccctgcggca cggggggaaa attcagcccc tccggcgttt gaggagcggg gtccggggcg
    19741 gagccccgtg gcaggggccg ggtcgcgcgg gtcgggttag tctctgagcg ccgcgatcgc
    19801 ctccgccagc gccgacggca cgtcggggac cagggcgtgg acaccgccgc gtacgacatg
    19861 acggccccct gccaccgtgt ggcggacgtc cgccgacgtc ccggcgaaga gcaccgtctc
    19921 ggcgccgagg cgcgggacgg gacccgccgt gcggaccgag tccagggcga tggtcgtgag
    19981 gtcggccaga gcgccctgct cgatggcgcc cgcgtcgggc cagccgaggg ccgcgtggcc
    20041 gtcggcggag gccgcgcgca gcagggccgc cgccgtccag tggccgcgcg tgtgcgagcg
    20101 gagccgctcg ttcagctcca tcgcccgcgc ctcttcgagc atgtcgatca ccgcgtggct
    20161 gtcgctgccg agcgagagcg ggctgcccgc ccgctggagg cggacggcgg ggccgatgcc
    20221 gtcggccagg tcgcgctcgg tggtggggca catgcaggtg cccgtcgacg tgccgccgag
    20281 cagcgcgatg tcctcgtccg tgaggtgcgt gttgtggacg cccgtggtgc gcgcgccgag
    20341 cacgccgtgg tcggcgagca ggcgcgtcgg ggtgcggccg tggacggcga ggcacgcgtc
    20401 gttctccgcc gtctgctcgg agaggtggac gtggagcggg gcgccgcggg ccccggccca
    20461 ctccgccacc gtgcccaact gccgcgcggg gaccgcccgt acggagtgga tcgccgcgcc
    20521 gatgcgcgcg tggtcgcggt ccttgaggag cgaggcccgc tccgcccacg cctgcgtcgt
    20581 cccgtcggag aagcggagct gatggtggtt gggctccttg ccgcgctcct cgtcgagcag
    20641 gccggaggcg acgtacgccg tgtccaggag cgtgatgcgc acgcccgcgt cggcggccgc
    20701 ctggatcagc gcctcgccca tcgcgttggg atcggcgtac ggcgtgccgc cggggccgtg
    20761 gtggaggtag tggaactcgc cgaccgtggt gatgcccgcg agcgccatct ccgcgtacac
    20821 cgcacgcgcg agcgcgtggt acgtctcggg cgtcagccgg tccgccaccg agtacatgac
    20881 ctcgcgccac gtccagaagg tgccggagcc gacctggacc gtgccgcgca gggcccggtg
    20941 gaaggcgtgc gagtgggcgt tcgcgaggcc gggcagtgtc aggccgcgca gcacctccgc
    21001 acccggtggg ggcgcctcgg cgcccgtgcg gaccgccgtg atccggtcgc cggtcacgtc
    21061 caccgccacg cccggctcga catgggtgcc gagccaggcg tgctccagcc agtacgtgtc
    21121 cgtccgctcc gtcgtcacct gcacgccagc ccttccagta cgtccgccag tgcggtcacc
    21181 ccggccaggc agtcgtcctc cgcggcgtgc tcggccgggg agtgcgagac gcccgtgggg
    21241 ttccgtacga acagcatggc ggtcgggatc gagccggaca aaatacccgc gtcgtgtccc
    21301 gcgcccgtgc cgagcacggg cagcggcctg tccgtgcccg cgcccaggat cgcgcccagc
    21361 tcgtcgcgga gcgcgtgctc gaactcgatc accggcgtga acgactcgcg tacgacgtcg
    21421 aggtcgatgc cgtgccgctc cgcgtactcg cgggccgcct tctcgatgcc ggtgacgacc
    21481 gtgtccaggg actcctggtc gggggcgcgc gagtccagcc agccgcggac gagggacggg
    21541 atcgcgttga cgccgttcgg ctcgacggag atcttgccga acgtggccac ggcgcccgcg
    21601 agttcggcct cgcggcgggc ggcgaggacc gtctccgcgt agctcagcat cgggtcgcgg
    21661 cggtccacga gccgggtcgt gcccgcgtgg ttggcctcgc ccctgaagtc gaagcgccag
    21721 cggccgtgcg gccagatcgc ggacgcgatg ccgacggggt cgcccgacag gtcgagggcg
    21781 cggccctgct cgacgtgcag ctccacgaac gcgccgatgc gggcgaggcg ttcggggtcg
    21841 gcgccgatgc cgtacgggtc gtagcccgcc gcctccatcg cctgcggcag cgtcacgccg
    21901 tcgccgtcgc ggagtttgtg cgcggcctcg atggtgagct gtcctgcggc gaggcgtgag
    21961 ccgacgcagg ccaggccgaa gcgggcgccc tcctcgtcgc cgaagttgac cagcgcgagg
    22021 ggcctggtga actccactcc cctgtggcgg agttcgtcga gcgcggcgaa ggaggagacg
    22081 acgccgaggg ggccgtcgaa ggcgccgccg tcggggacgg agtccaggtg ggatccggtg
    22141 acgacggcgt ccccctggcg cgggtcgccg agccaggccc actggttgcc gttgcggtcc
    22201 agttcgtagg tgaggccccg ggtgtccgcc tgtgccttga accacgcccg gcagtcggcg
    22261 tcggcgccgg tccacgcgta gcggcggtag ccgtttgaac cggtgtccct gccgatgggc
    22321 ttgaggtcgc gccacatctc ctggaacgag ggggccgatg tcgcggggct ctgccccgga
    22381 ccccgctcct caaacgccgg aggggctgga ttaccggccc ccggagccgc tgaattcccg
    22441 gccgcccgag aggctggatt actcactcgc cctcccgcat gggaacccgc acgccacgct
    22501 cgtcagccac gcgctccgcg atgtcgtacc ccgcgtccac gtgccggatc acgcccatgc
    22561 ccgggtcgtt ggtgaggacg cggcggatct tctcgcccgc gagcgccgtg ccgtcggcca
    22621 ccgagacctg gcccgcgtgg atcgagcggc ccatgccgac gccgccgccg tggtggaggg
    22681 agacccagga ggcgccggac gcgacgttca ccatggcgtt caggaggggc cagtcggcga
    22741 tcgcgtcgga gccgtcgagc atgccctccg tctcgcggta gggggaggcc accgagccgc
    22801 agtccaggtg gtcgcggccg atggcgaggg gcgcggcgag cgtgccgttg ccgaccatgt
    22861 cgttgaacat gtcgcccgcc ttgtcgcgct cgccctggcc gagccagcag atgcgcgcgg
    22921 ggaggccctg gaagtggacg cgctcgcccg ccatcttgat ccagcggtgg agggactcgt
    22981 tctcggggaa gaggtcgagg agcgccttgt ccgtcttgtg gatgtcggac gcctcgccgg
    23041 agagcgccgc ccagcggaac gggcccttgc cctcgcagaa gagcgggcgg atgtaggcgg
    23101 gcacgaagcc ggggaacgcg aacgcgcggt cgtagcccgc gagttgggcc tcgccgcgga
    23161 tcgagttgcc gtagtcgaag acctcggcgc ccgcgtccat gaagccgacc atcgcctcga
    23221 cgtggcgcgc catggactcg cgggcgcggg tggtgaagcc cgccgggtcc ttggtcgcga
    23281 gcgtctccat gtcgtcgaag tcgacgccga cggggaggta cgcgagcggg tcgtgggccg
    23341 aggtctggtc ggtcacgatg tcgatgggcg cgccctcggc cagcatctgc ggcagcagct
    23401 ccgccgcgtt gccgaggagg ccgatggaga gcgggcggcg ggcgtcgcgg gcctcggtgg
    23461 ccagctggag ggcgtgggcc aggctgtcgg cccgcacgtc caggtacttg tgctcgatgc
    23521 ggcgctcgat ggcgcgcggg tcgacgtcga tacagatggc gacgccgtcg ttcatcgtca
    23581 cggcgagcgg ctgggcgccg cccatgccgc cgagtccggc ggtgagggtg atcgtccccg
    23641 cgagggtgcc gttgaaccgc ttggcggcga ccgcggcgaa cgtctcgtac gtgccctgga
    23701 ggatgccctg cgtgccgatg tagatccagg agcccgcggt catctggccg tacatggtga
    23761 ggccgagctg ctccaggcgg cggaactcct cccagttcgc ccagtcgccg accaggttgg
    23821 agttggcgat caggacgcgc ggggcccact cgtgggtctg catcacgccg accgggcggc
    23881 cggactggac gagcatcgtc tcgtcctgct tgagggtctt cagcgtgcgc accatcgcgt
    23941 cgaaggagcg ccagtcgcgg gccgccttgc cggtgccgcc gtagacgacg agcttgtcgg
    24001 ggtgctcggc gacctcgggg tcgaggttgt tctggagcat gcggagggcg gcttcctgct
    24061 gccatcccag ggcgctcagt tcagtgccgc gaggtgcccg aacggggcgg ggtcctgaca
    24121 tggcggtgcc tcctagcatg cgactgtgac cttgatattc acatcctgat ggcctgaata
    24181 gagctagtca atagcgaacg aatgcacgag tacgccagcg gtgccccgcc ccggatgatt
    24241 ggctggatca catgggccac gacgaggaac acgaccagga aaagactcag gacctgcgcg
    24301 ggagcggcga cagcgccacc cgccgcgacc aggccgtccg cgccgccgtc gaacagggcg
    24361 tcgtggggcc cgccgccccc gtcgtcggcc tcctcgacgt caccggcatc cgcgcggccg
    24421 ccgccgagct gcgcgccgcc ttcgacgccg tcgtcgagcc cggcaccccc gtcctgcacg
    24481 ccttcgcggt caaggccgcc ccgctggtcc ccgtgctcag gctgctgcgc tcggcgggca
    24541 tcggcgccga ggtggcgagc cccggcgagc tcggcatcgc cagggccgcg ggcatcgcgc
    24601 cctcggacac cgtcctcgac tcccccgcc
//
