LOCUS       NZ_CP022685            21317 bp    DNA     linear   CON 17-JAN-2024
DEFINITION  Streptomyces formicae strain KY5 chromosome, complete genome.
ACCESSION   NZ_CP022685
VERSION     NZ_CP022685.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces formicae
  ORGANISM  Streptomyces formicae
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9611874)
  AUTHORS   Holmes,N.A., Devine,R., Qin,Z., Seipke,R.F., Wilkinson,B. and
            Hutchings,M.I.
  TITLE     Complete Genome Sequence of Streptomyces formicae KY5, the
            formicamycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9611874)
  AUTHORS   Holmes,N.A., Devine,R., Qin,Z., Seipke,R.F., Wilkinson,B. and
            Hutchings,M.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2017) School of Biological Sciences, University of
            East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, United
            Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.0; Newbler v. 2.3
            Assembly Name                     :: KY5 Genome
            Expected Final Version            :: yes
            Genome Coverage                   :: 56.0x
            Sequencing Technology             :: PacBio; 454; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/17/2024 10:10:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,274
            CDSs (total)                      :: 8,185
            Genes (coding)                    :: 8,082
            CDSs (with protein)               :: 8,082
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 39 of 103
            Pseudo Genes (incomplete)         :: 77 of 103
            Pseudo Genes (internal stop)      :: 11 of 103
            Pseudo Genes (multiple problems)  :: 22 of 103
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:13:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 841348
            Orig. end                         :: 862665
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022685.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Matthew Hutchings,
            University of East Anglia, UK.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21317
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="9"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21317
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21317
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11317](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11317
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(730..744)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.77"
                     /tool="antismash"
     gene            1199..1984
                     /locus_tag="KY5_RS03375"
                     /old_locus_tag="KY5_0678"
     CDS             1199..1984
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387771.1"
                     /locus_tag="KY5_RS03375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0678"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_098240762.1"
                     /transl_table=11
                     /translation="MTSPSSGSRIDTSRAHPARVYDWLLGGKDNYPVDQEVAEKLPKEA
                     RLNAMRNRAFMHRAAAWLAGNGIDQFLDIGTGIPTEPNLHQIVQGIVPSARIAYADNDP
                     IVLRHAEALLVSSREGATDYIEADVRRPDAILEHARTFLDFSRPVALSMIALMHFITDE
                     EDPYGLTRTLVDALPSGSYLMFSHGTTDEHPHLVKSVTTTYRKGEIPLRMRTRAEVEPF
                     FEGLDLLDPGLVTATKWYKDSPAPTEELSGFYVGVARVP"
     gene            2237..5218
                     /locus_tag="KY5_RS03380"
                     /old_locus_tag="KY5_0679"
     CDS             2237..5218
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182083.1"
                     /locus_tag="KY5_RS03380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0679"
                     /product="family 16 glycoside hydrolase"
                     /protein_id="WP_098240763.1"
                     /transl_table=11
                     /translation="MLLTALLCGGLLAPSTAASAEDRPRPFADLPPQEPGVTLRVFDVR
                     TPLKKLCDLKPAQTPNVDKLIPAADWKSTEGFGFSDNFVSQIIGNLNVPTAGSYDFRLI
                     SDDGSRLFLGDRRVIDHDGLHGAEPKDGSVTLNAGHQPLRIDHFDAGGDQQVTLQWKPP
                     GADAFTTVPNSVLSTDADVVRVTAPGRKECEGTLDTPGDGLPLTEVNPGYTLTDLRPKG
                     FEPQVTAMDWLPDGRLAISTWGGSTETKGEVYLLDNVTGDTGPDKVTYKKIADGLKEPM
                     GITYADGKLYVSEKHQLTELNDTNGDDVADEKRKIAAWPYGGNFHEFAFGLLYDKGDFY
                     LNLSVAINYGGATTDPQPAPNRGTTIKVNKATGKVSYLAGGLRTPNGIGRGPGGDLFVT
                     DNQGGWLPASKLVHIKQDRFFNHYMNPDGPYDDKAVTKPVLWLPQNEIANSPSTPLRLR
                     KGPFAGQMVFGDVTYGGLQRADLEKVGGEYQGAVFRHTQGLESGITRISEGPDGAIYTG
                     GLGADGNWGQAGKLRFGLQKLTPNGRTAFDVKTMRATRDGFELTYTNPLSEETAAKLTK
                     GAYAVEQWRYVPTPAYGGPKVDEESLPVASARLSEDRRKVTLTIPGLKSDRVVHVRSPR
                     PFSSSEGEQLWSTEAWYTLNAKPGPPEPVTTYDAESAKLSGGAAIDTEHAGYTGGGFVD
                     GFGDKGARAAFDVVVDKKGSYDVGLRYANGPHPAPGTKTIGVSVNGGPARRTSLPSTGE
                     WKRWSTKTERLDLRKGHNTLTYVVGPEDTGHVNLDALDVRRPGSRIDLFSGGSAATAWQ
                     HSDGRAPEWPHTAEKSMEVCCGDLRTKQHFEDFTLHVEFRVPKLPDDVTGQDRGNSGVY
                     LQERYEVQILDSYGVAKLANNEAGAIYLKKAADLNASTAPETWQTYDITFRAARFDAAG
                     KKTSDARITVVWNGKKVHDDVAVDGPTGAGDPESAAAGAIRLQDHGNKVRFRDVWVEPL
                     EPLT"
     misc_feature    2351..2353
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5322..5762)
                     /locus_tag="KY5_RS03385"
                     /old_locus_tag="KY5_0680c"
     CDS             complement(5322..5762)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018528960.1"
                     /locus_tag="KY5_RS03385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0680c"
                     /product="OsmC family protein"
                     /protein_id="WP_098240764.1"
                     /transl_table=11
                     /translation="MADYRIETVRNGERDWTARNDRGAEVRIAAADNPEAQPSFTPVEL
                     LLAALGGCGGLVVDRTARTVEHDGLRIVVDSVSRPEDDGRVGVLRVSYEIDLAEGEDQA
                     AEKLERAIRLTHEKYCTVSRTVEHGARVEALGPDGTTLFAGG"
     gene            complement(5851..6243)
                     /locus_tag="KY5_RS03390"
                     /old_locus_tag="KY5_0681c"
     CDS             complement(5851..6243)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014717.4"
                     /locus_tag="KY5_RS03390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0681c"
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_107645684.1"
                     /transl_table=11
                     /translation="MENDTRTLFLALAGVSLLIGAIGIGNTTLVAVLERRHEIGLRRAI
                     GASRRSILSQFLFESGLLGALGGLVGTVGGLDLTISIALAKGWTAALSPWLLVAGPLLG
                     LGVGLAAGLYPALKAARLEPVAALAS"
     gene            <6214..>6700
                     /locus_tag="KY5_RS42080"
                     /pseudo=""
     CDS             6214..>6700
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018853779.1"
                     /locus_tag="KY5_RS42080"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="zinc-binding dehydrogenase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEQGPGVVLHMGPQLLGVGRYLGEQLVGAAR"
     gene            complement(6758..8131)
                     /locus_tag="KY5_RS03400"
                     /old_locus_tag="KY5_0682c"
     CDS             complement(6758..8131)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1246: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013646.4"
                     /locus_tag="KY5_RS03400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0682c"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_098240766.1"
                     /sec_met_domain="DAO (E-value: 2.6e-07, bitscore: 29.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKIQQSSSPGTRWDRAVVIGGGYAGLVTARVLADHFTEVLVLER
                     DPMDADTGVHPHVPQGYHAHALLARGGDALERLFPGLRAELAELGAPVFDYGERISFLL
                     PTGYAPTTTVGVPVQTFTRDELERRLRQWVLALPAVRLLAATRCETVTSSVPGRLDRVR
                     YRTDGAATSDDVTADLVVDASGRTTKIDAWLGEARIPMSAKSVIKAKITYTSACYERPP
                     QDELDFDVAYQMAFAPGVPRGGVILAVEHHRWMCSLFGVSDHVPPTDDDGYLDFAHSLG
                     NPRLAEQIKRGTRQGEISRYTNPGDEWRLHHKNARWPERLIAIGDALCVFNPVYGQGLT
                     VAALEAELLDGLLRRRRAQASGLDGLSRAYLRAAAKVIQVPWTMATSSDLMWSPEGQPL
                     SARFAHWYNRHVFALAVRDQDVWARFVRVLNMTAPPTLLFRPRVLGGVLRHAFTRRSG"
     misc_feature    complement(8276..8288)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            8544..9956
                     /locus_tag="KY5_RS03405"
                     /old_locus_tag="KY5_0683"
     CDS             8544..9956
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157664.1"
                     /locus_tag="KY5_RS03405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0683"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_098240767.1"
                     /transl_table=11
                     /translation="MTVDSSPEARLEPPRQSSLGTAAARNLATTTKSAPQMQEITSRWL
                     LRMLPWAETKGGAYRVNRRLSYTVGDGTVEFVQDGATVRVIPRELGELALLRGYDDVDV
                     LTAIAGRCVQRDFRAGETLVERGAPADQLHLIAHGRISQTSEGGYGDEVDLDVLADGDQ
                     FGEHALLDEDARWEVTATAETSGTLLTLSRADFAAVRSTAPGLNEHLEAFTSRSQRRQN
                     HRGEAEIAMSAGHTGEHALPGAFVDYELKPREYELSVAQTILRIHTRVADLYNGPMNQT
                     KEQLRLTIEALRERQEHELVNNREFGLLHNADFKQRLQPHSGPPTPDDLDELLCRRRGS
                     KFFLAHPKTIAAIGREFNARGIYPDHVDLGGQQVPAWRGVPILPCGKIPITEEKTSSIL
                     CMRTGEENQGVIGLHQTGLPDEYEPGLSVRFMGLNEQAITSYLVSTYYSAAILVPDAVG
                     VLENVQIARWPR"
     gene            10001..11317
                     /locus_tag="KY5_RS03410"
                     /old_locus_tag="KY5_0684"
     CDS             10001..11317
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032492607.1"
                     /locus_tag="KY5_RS03410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0684"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_098240768.1"
                     /sec_met_domain="T1TS (E-value: 1.3e-66, bitscore: 224.7,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPELTPPQPSLPEAAARFGAHVLADAAARACDIKAVTGTAPCA
                     PVATDPPTPSVPSPSVPAQPEPPAVSVPAGSDVDLERVLRGPNGLGTTGLRLTPRDEPA
                     TAAEPSAAEGKPIPGLYHHPVPEPDPVRVEEVSRRIKSWALDEVSLYPDDWEEQFDGFS
                     VGRYMVGCHPDAPTIDHLMIATRLMVAENAVDDCYCEDHGGSPIGLGGRLLLAHTALDP
                     LYTTAEYQPQWAESLHADAPRRAYRSAMEYFTGTASPAQSDRFRHDMARLHLGYLAEAA
                     WSQEDHVPQVWEYLAMRQFNNFRPCPTITDTVGGYELPADLHARPDMQKVIGLAGNATT
                     IVNDLYSYTKELDAPGRHLNLPVVIAEREGLSDRDAYLKSVEVHNDLMHDFETEAAALA
                     AACPVPTVQRFLRGVAAWVDGNHHWHRTNTYRYSLPDFW"
     gene            11323..12216
                     /locus_tag="KY5_RS03415"
                     /old_locus_tag="KY5_0685"
     CDS             11323..12216
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009720957.1"
                     /locus_tag="KY5_RS03415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0685"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_098240769.1"
                     /transl_table=11
                     /translation="MESSVTSTELTATDALVRIPGPATPYQGDIARYWDGEARPVNLRL
                     GDVDGLYHHHYGIGEVDRTALGEPEDSESEKKLIAELHRLESAQADYLLGHLGDIGRDD
                     TLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAKQAEFANRRAQELRIQDHVRARVCNMLA
                     TPFETGQAAASWNNESSMYVDLQDLFAEHSRVLKVGGRYVTITGCWNPRYGQPSKWVSQ
                     INAHFECNIHSRREYLRAMADNRLVPQAVVDLTPDTLPYWELRATSSLVTGIEEAFINS
                     YKDGSFQYLLIAADRV"
     gene            12373..12804
                     /locus_tag="KY5_RS03420"
                     /old_locus_tag="KY5_0686"
     CDS             12373..12804
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621939.1"
                     /locus_tag="KY5_RS03420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0686"
                     /product="VOC family protein"
                     /protein_id="WP_098240770.1"
                     /transl_table=11
                     /translation="MSVLDSPIPRFHLAVPVDDLAAARRFYGEVLGLEQGRSADTWIDW
                     NLHGHQFVTHLAPGRARPVHNPVDGHDVPVPHFGLILTVPVFEELAGRLRAAGTDFVIE
                     PYVRFAGQTGEQRTMFLLDPAGNALEFKAFADDSQVFAS"
     misc_feature    12933..12948
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.37"
                     /tool="antismash"
     gene            12958..14472
                     /locus_tag="KY5_RS03425"
                     /old_locus_tag="KY5_0687"
     CDS             12958..14472
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569412.1"
                     /locus_tag="KY5_RS03425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0687"
                     /product="carotenoid oxygenase family protein"
                     /protein_id="WP_098240771.1"
                     /transl_table=11
                     /translation="MTSHTRRRVLQGAALAAAGSVVGGYGLGPGATTARAAAGGGGTPA
                     GGATSTPFLEGAFAPVTEELTAFDLPVTGRVPRDLDGRYLRTGPNPLGLEDPRAHHWML
                     GDGMVHGVRLRDGRAEWYRNRWVRSSQVAEKLGEPYPGPVPPDDFPCNTHVIPYKGRIL
                     AVQESGPLPYELDGELGTVRPYDFRGTLKGAFTAHTKYDAAADELHAVAYYPTWDHVRH
                     IMIDRTGRVARTHKIPVTDAPMMHDFALTEKYVVIVDVPITFDPAAAEAGAIVPYIWNK
                     RHPMRLGVMPRTGGTTRWFEIDPVYFSHTLNAYDQGDELVLEHISMPAPFYAAGRGNGG
                     PSSTGKPTLNRWTVDLRAGRVRTTRIDDMAQEFPRVNESLVSRRHRFAYTASAAEMWRA
                     YETVDGVPPDEKFTNCLVKQDMLRGSKQVHRFPKGAGASEPVFVPRRGARDEDDGYILS
                     YVHDPDRGASDLVILSAQDFKGHPLARVHLPGRVPLGFHGSWVADQ"
     gene            14523..16256
                     /locus_tag="KY5_RS03430"
                     /old_locus_tag="KY5_0688"
     CDS             14523..16256
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487005.1"
                     /locus_tag="KY5_RS03430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0688"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_098240772.1"
                     /transl_table=11
                     /translation="MLIKLALHRLAPHRSAVSLTVLLQVAQTGALLWLPALNAVIIDEG
                     VVRGDTGVIVRVGGQMLALTLVQVLCALGALHFGARTALAVGRDLREDVFAHVQRLSVH
                     QVARFGTPSLVNRTTNDVLNVQTLLLTVLTLLVTAPLMCAGGVIMAFGQDVPLSSVLLL
                     LVPVLAVQAALVLRRLRPLVRSLQELVDDVTRTLREQITGVRVVRAFVRDAYEQRRFAR
                     SNDNLTDIATRVGRMTTLLLPLGATTVNLFGVAVVWLSAPRIEDGSMRIGALTALITYL
                     TLILTSVMTVTGLFMVLPRGEVSAERIADVLGTEPEIGPPARAAARPSRPCRVEWRGVE
                     LRYPGAEVPVLSALALTAEPGAVTAVIGPTGSGKTTLLGLVPRLFDVTAGTVRVGGQDV
                     RDLDPAVLTRTVGMVPQKAYLFSGTVASNLRYGRPDASDDDLWRALEVAQARDFVARMP
                     GRLRAPITQGGGNVSGGQRQRLAIARTLVAAPDVYLFDDAFSALDQSTEAALRAALAEE
                     TADATVVMVAQRVSSVRGADRIVVLDDGRVVGTGSHEELCESSPTYRAIVRSQSPSGVV
                     A"
     misc_feature    14541..14543
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16253..18175
                     /locus_tag="KY5_RS03435"
                     /old_locus_tag="KY5_0689"
     CDS             16253..18175
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143936.1"
                     /locus_tag="KY5_RS03435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0689"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_098240773.1"
                     /transl_table=11
                     /translation="MRWPRRTAAAEQQEAPARAADFQGAARRLLRRVRRQRALFYGMLA
                     LGTTSVTLNVAGPKVLAHATDLVVAGLVGRRLPEGTSRADAVGRLREQGDDGLADMLGA
                     VDVVPGHGIDQGALAATLSLAVAVYALSGLCWIAQGRVTTRVVQRTVRALRQDVAEKLS
                     RLPLSHFDRQPRGEILSRATNDIDNIAQTLQQTISQLTNSLLLVVGVLGMMFWISPPLA
                     LVALVTVPLTFAVTALIARRAKPHFVRQWSRTGRLTSQVEEEYTAHDLVLLHGRQQASA
                     DEFARHNEELFQAGYRAQFLSGAIQPALTFMGNLGYVLVAVASGIRVASGALSIGDAQA
                     FVQYSRQFGGPLTNAASVANLAQSCAVSAERVFALLDAPEVRRTPTTSRPNGAQEAQPP
                     VGRLDFEDVSFRYTPEEPLIEGLSLSVEPGQQVAVVGPTGAGKTTLVNLLPRFYDVTKG
                     RILLDGVDIAELPHEELRRAIGMVPQDAWLFAGTIADNIAYGREGATRTEVAEAARAAH
                     ADHFVRTLPDGYDTLLGDGGAGVSAGERQLITIARAFLADPLLLVLDEATSSVDTHTEA
                     LVQQAMARLSEGRTSIVIAHRLATVRDADVIVVLDRGSVVEQGTHAQLLAAEGAYARLC
                     AAQLR"
     gene            complement(18187..18903)
                     /locus_tag="KY5_RS03440"
                     /old_locus_tag="KY5_0690c"
     CDS             complement(18187..18903)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012427.4"
                     /locus_tag="KY5_RS03440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0690c"
                     /product="nucleotide disphospho-sugar-binding
                     domain-containing protein"
                     /protein_id="WP_234363134.1"
                     /sec_met_domain="MGT (E-value: 4.3e-30, bitscore: 104.2,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASVLMSGPPAEVNVVFVPREFQFAAETFDDGYHFVGPSLDAEGE
                     VAPDADVCAAADDEPLVYVSLGTASRRPGFFALCRDAFADTGQRVAMATGEHIDPAELG
                     PLPPEFDVRPYFPQRAVLRRATAFVSHGGMNSVMESVHAGVPLVVVPERPEQEANARRV
                     EELALGRWLVGADLTADVLRAAVASVASDTAVRAGIDRMRRACAAAGGAPAAADVVETV
                     LAAERDRSPGDALAGG"
     gene            18920..19180
                     /locus_tag="KY5_RS03445"
     CDS             18920..19180
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KY5_RS03445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_159072480.1"
                     /transl_table=11
                     /translation="MARRRSLASTGRRVALSGPCAPGTRPARWVWLLPAPPAHARWLAG
                     TLPGARLAHIPGMGHLLHPAVTARLAGEILAHTAAASGAAR"
     misc_feature    complement(19748..19763)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.82"
                     /tool="antismash"
     misc_feature    complement(20749..20764)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
ORIGIN
        1 ggcagcagcc gcgttgggcg tcggcctcgc cttcgtcgga ctgcccgccc ccgccgcgtc
       61 cgcggccgcc gtcagttgcc cggacctcgg cacgggcgac tccaacggcc tggacatgcg
      121 gtactggcgc ccgtcgcccg acgggctcgt ctgcgaggcg gagttcacct cggacgccct
      181 cttcaccgcg cgcgggccgg gggcgcccca gatcgatccc gtgcgcagac ccgtgcgcgt
      241 gcgcgtccac ctgcccgcgg actacgaccc gtccgcccgc taccccgtgc tctatctcct
      301 gcacggcggg gccgccgact acgagcagtg gtcaagtggc ggcggtgaca tcacccggag
      361 cgtcaaagag gccgggttca agggcatcgt ggtgatgccc gagggcggca aggtcggctt
      421 ctactccgac tggcccggct acacgtacgg caacttcaca ccccagtggg agaccttcca
      481 catcaagcag ttggtgccct ggatcgacgc gcacttcgcc acgtccggcg agcgcgccgt
      541 cgccggtatg tcgatgggcg gcttcggcgc cctgaagtac gcggcccaac acccggacat
      601 cttcagtgcc gtgggtgcct tctccggcgg cacggacctc cgtcgccccg accaccagga
      661 gatcatcaac aacggcacca ccctctacgg ggcacgtttc tggtggcacg gcgcgggcgc
      721 cgacctcggg aacttctgga aatacctctt ccccggcaac cccgacgcgc tgcggcgcac
      781 ggagctggtc ttcggaccgc agtccggctg gccctcgttc aaccccgccc aggtcgccga
      841 gacgcgcccc gccgcctacc gctcgtacgg cggcaagatg gcgctctaca gcggtcgcgc
      901 cgaggacccg tacgtctgga acaccgaact ccacaagacc ctgaagcggc agaacgtctc
      961 ccacctgtac tgctcgggcc ccgacggaca cgacttcacg acctggaccc cggcgctgaa
     1021 gcacttcctc cggttcgcgt acgggaccgc gtccacagcg tgcccggaca gcggcggctg
     1081 gcggcaggag cagtgaggca cgcgcacgga ccgggtatcg tcgtcggcca ctcaccgcga
     1141 tgatcaggcc aatgccataa tcgccgaggt ccctgccgcg cacacgctgg agtcacccat
     1201 gacgtcaccg tcctccggaa gccgtatcga cacgagcagg gcgcatccgg cgcgcgtcta
     1261 cgactggctg ctgggcggca aggacaacta tccggtcgac caggaggtgg cggagaagct
     1321 gccgaaggag gcccggctca acgccatgcg caaccgggcc ttcatgcacc gggcggcggc
     1381 ctggctcgcg ggcaacggga tcgaccagtt cctcgacatc ggcacgggca tcccgaccga
     1441 gccgaacctg caccagatcg tgcagggcat cgtgccgtcg gcgcggatcg cctacgccga
     1501 caacgacccc atcgtgctgc ggcacgcgga ggcgctgctc gtcagcagcc gcgagggcgc
     1561 caccgactac atcgaggcgg atgtgcgccg gcccgacgcc atcctcgaac acgcccgtac
     1621 gttcctggac ttctcgcggc ccgtcgcgct ctcgatgatc gcgctgatgc acttcatcac
     1681 cgacgaggag gacccctacg ggctcacgcg gacgctggtc gacgcgctgc cctccgggag
     1741 ttacctgatg ttctcgcacg gcaccaccga tgagcacccg cacctcgtga agtcggtgac
     1801 gaccacctac cgcaagggcg agattccgtt gcggatgcgg acgcgtgccg aggtcgagcc
     1861 gttcttcgag gggctcgacc tgctggaccc ggggctcgtc accgcgacca agtggtacaa
     1921 ggactccccg gcgcccaccg aggagctgag cggcttctac gtgggcgtcg cccgggtgcc
     1981 gtaggcgccg tacgcaaccc aagacctggc cgacacacct cagttcttcc tttctgagga
     2041 caaagtatgg acgcgctccg ggggcatccc tacgctgagc gtcgctttgc cacagagatc
     2101 tgcgtaaccc atgccggaat accggaacca cgcaggagga agagtgaagc cacgtcccag
     2161 gccgctgtcg gggccgcccc gccgcagagc ccgaagagcc cgaagagccc gaagagccgc
     2221 cgccgggtcc accggtgtgc tgctgaccgc tctcctctgc ggcgggctcc tcgcccccag
     2281 caccgccgcg tccgccgagg accggccgcg gccgttcgcg gatcttccgc cgcaggaacc
     2341 cggcgtcacc ttacgggtgt tcgacgtccg gaccccgctc aagaagctct gcgacctcaa
     2401 gcccgcgcag acccccaacg tcgacaagct gatcccggcc gccgactgga agtccaccga
     2461 ggggttcggg ttcagcgaca acttcgtgtc gcagatcatc ggcaacctga acgtgcccac
     2521 agcgggctcg tacgacttcc ggctgatcag cgacgacggc tcccggctct tcctcggcga
     2581 ccggcgggtc atcgaccacg acggactgca cggcgccgaa cccaaggacg gctcggtcac
     2641 gctcaacgcc ggacaccagc cgctgcgcat cgaccacttc gacgcgggcg gcgaccagca
     2701 ggtcaccctc cagtggaaac cgccgggggc cgacgccttc accaccgtgc cgaactccgt
     2761 gctgagcacg gacgccgatg tcgtacgggt taccgcgccg ggccgcaagg agtgcgaggg
     2821 cacgctcgac acccccggcg acggcttgcc gctcaccgag gtcaaccccg gatacacgct
     2881 gaccgacctg cgccccaagg gcttcgagcc gcaggtgacc gcgatggact ggctgcccga
     2941 cgggcggctc gcgatctcca cctggggcgg cagcaccgag acgaagggcg aggtgtacct
     3001 cctcgacaac gtcaccgggg acaccgggcc cgacaaggtc acgtacaaga agatcgccga
     3061 cgggctcaag gagccgatgg gcatcacgta cgcggacggg aagctgtacg tgtcggagaa
     3121 gcaccagctg accgagttga acgacacgaa cggcgacgac gtcgccgacg agaagcggaa
     3181 gatcgccgca tggccgtacg gcgggaactt ccacgagttc gccttcggac tgctctacga
     3241 caagggcgac ttctatctga acctctccgt cgccatcaac tacggcggag ccaccaccga
     3301 tccgcagccc gcaccgaacc gcggcacgac catcaaggtc aacaaggcga cgggcaaggt
     3361 gagttacctc gccggtgggc tgcgcacccc gaacggcatc gggcgcggcc ccggcggtga
     3421 cctgttcgtc acggacaacc agggcggctg gctgcccgcg tccaagctcg tgcacatcaa
     3481 gcaggaccgc ttcttcaacc actacatgaa tccggacggg ccgtacgacg acaaggccgt
     3541 caccaagccg gtgctgtggc tgccgcagaa cgagatcgcc aactcgccca gtacgccgct
     3601 gcggttgagg aaggggccgt tcgccgggca gatggtcttc ggcgacgtga cgtacggcgg
     3661 actccagagg gccgatctgg agaaggtcgg cggcgagtac caaggcgcgg tgttccggca
     3721 cacccagggc ctggagtcgg ggatcacccg gatcagcgag ggccccgacg gcgcgatcta
     3781 caccggtggc ctgggcgccg acggcaactg gggccaggcg ggcaagctcc gcttcggcct
     3841 gcagaagctg acgccgaacg gcaggacggc cttcgacgtc aagacgatgc gcgccacccg
     3901 cgacggcttc gaactcacct acaccaatcc cctgtcggag gagaccgcgg ccaagctgac
     3961 caagggcgcg tacgcggtcg agcagtggcg ctacgtgccg acgcccgcgt acggcggccc
     4021 gaaggtcgac gaggagtcgc tgccggtggc gtcggcgcgg ctctccgagg accgccgcaa
     4081 ggtgacgctg accatcccgg gcctgaagtc ggaccgtgtg gtgcacgtcc gttcaccccg
     4141 cccgttctcg tcgtccgagg gcgagcaact gtggtccacc gaggcctggt acaccctgaa
     4201 cgccaagccg gggccgccgg agcccgtcac cacctacgac gccgagtccg ccaagctgtc
     4261 ggggggcgcg gccatcgaca cggagcacgc cggatacacc ggtggcggtt tcgtggacgg
     4321 cttcggcgac aagggcgcgc gggccgcctt cgacgtcgtg gtcgacaaga agggttcgta
     4381 cgacgtgggc ctgcgctacg cgaacggccc gcatcccgcc cccggcacca agacgatcgg
     4441 ggtcagcgtc aacggcggcc cggcgcgtcg gacgagtctg ccgtccaccg gcgagtggaa
     4501 acgctggtcc accaagaccg agcggctcga cctgcgcaag ggccacaaca cgctcaccta
     4561 cgtcgtgggg cccgaggaca ccggccacgt gaacctcgac gcgctggacg tgcgcaggcc
     4621 cggcagcagg atcgacctct tctcgggcgg cagcgccgcc accgcctggc agcactccga
     4681 cgggcgcgcc cccgagtggc cgcacaccgc ggagaaatcg atggaggtct gctgcggcga
     4741 tctgcgcacc aagcagcact tcgaggactt cacgctgcac gtcgagttcc gggtgccgaa
     4801 gctgccggac gacgtcaccg ggcaggaccg gggcaacagc ggggtctacc tccaggaacg
     4861 gtacgaggtg cagatcctgg actcgtacgg cgtggcgaag ctcgcgaaca acgaggcggg
     4921 ggcgatctat ctgaagaagg ccgccgacct caacgcgtcc acggcgccgg agacctggca
     4981 gacgtacgac atcaccttcc gcgccgcccg cttcgacgcg gcggggaaga agacgtcgga
     5041 cgcccggatc acggtggtgt ggaacgggaa gaaggtccac gacgacgtcg ccgtcgacgg
     5101 tccgacgggc gcgggtgacc cggagtcggc ggcggccggt gccatccgcc ttcaggacca
     5161 cggcaacaag gttcgcttcc gcgacgtgtg ggtggagccg ctggagccgc tcacttgatc
     5221 gcggccgagg gaccgctccc ctgccgacgg tccggtcgtc ggcaggggtt ccctcggtgg
     5281 ggattccctc ggtgggggtt ccctcggtgg gggttcgacc gtcatccccc ggcgaagagg
     5341 gtggtgccgt cggggcccag cgcctcgacg cgcgcgccgt gttcgacggt gcggctgacg
     5401 gtgcagtact tctcgtgggt cagccggatg gcacgctcca gtttctcggc ggcctggtcc
     5461 tcgccctcgg ccaggtcgat ctcgtaggag accctgagga cgccgacgcg gccgtcgtcc
     5521 tcgggccggg agaccgagtc cacgacgatg cgcagcccgt cgtgttcgac ggtgcgggcg
     5581 gtgcggtcca cgacgagtcc gccgcagccg ccgagcgcgg cgaggaggag ttcgacgggg
     5641 gtgaaggagg gctgggcctc cgggttgtcg gcggcggcga tccggacttc ggcaccccgg
     5701 tcgttgcggg ctgtccagtc gcgttcgcca ttgcgtacgg tctcgatgcg gtagtcggcc
     5761 atggcggaac ggtaaccagg ggcgggcccg ccaccccgta ggccggtcct gtgtgtgtcg
     5821 gccaggtggc cggacgccgg gccgcggggg ctacgacgcg agcgccgcca ccggctccag
     5881 ccgtgcggcc ttgagcgccg ggtagagccc cgcggccagg ccgacgccca gaccgagcag
     5941 cgggcccgcg acgagcagcc agggcgagag cgcggcggtc cagcccttcg ccagggcgat
     6001 ggagatggtc agatcgaggc cgccgacggt gccgaccaga ccgccgagag cacccagcaa
     6061 gccgctctcg aagaggaatt gggagaggat cgagcggcgc gacgcgccga tggccctgcg
     6121 caggccgatc tcgtggcgcc gttcgaggac cgcgaccagc gtggtgttgc cgatgccgat
     6181 cgccccgatc agcagcgaca ccccggcgag tgcgaggaac agggtcctgg tgtcgttctc
     6241 cacatgggcc cgcaactgct tggggtcggg cggtacttgg gcgagcagct cgtcggggcg
     6301 gcccggtgac agcggcctgg gcgcacgcgc ccgccacctg gagcgacgag caggccaccg
     6361 gtgcggggct ggcctccgtg accgcgctgg gcgggctcaa ggcgctcggc ccgctgcggg
     6421 ggcgcacctg ctcgtcgagg gcgccgccgg aggcgtgggc agggccgtgg ccgagatcgc
     6481 ggtggcccgg gggggggcga tcgtgggcgg ccccgcgcgg atggcgacgg ttgcagacca
     6541 cgccaacgcg cggcgtctgg gtgtgcgcgt ggccaacgcg gagaacgact ccacgctcct
     6601 cgccgaatcg gccgaacttg atcagcaggg cccgctcgaa cggatcgcgg acgcacacac
     6661 gtatgtcgag cgcgggcaca cgcgggggaa ggtcgtggtg tgcgcctgcg cctgccccgc
     6721 agcgcggtcc gcccgtggcc tcggccgcgg acgggcctca gcccgagcga cgtgtgaagg
     6781 cgtggcggag cacaccgccg agcaccctcg gccggaacag cagcgtgggc ggggccgtca
     6841 tgttcaggac gcggacgaac cgcgcccaca cgtcctggtc ccgcacggcc agcgcgaaga
     6901 cgtgccggtt gtaccagtgg gcgaagcgcg cggagagcgg ctggccttcg ggcgaccaca
     6961 tcaggtcgga gctggtggcc atggtccagg ggacctggat gaccttggcc gccgcgcgca
     7021 ggtaggcccg gctgaggccg tcgagccccg acgcctgcgc cctgcggcgc cgcaacagcc
     7081 cgtcgagcag ctcggcttcg agcgcggcga ccgtcagccc ttgtccgtac accgggttga
     7141 agacgcagag agcgtcgccg atcgcgatca ggcgttcggg ccagcgggcg ttcttgtggt
     7201 gcaggcgcca ctcgtcgccg gggttggtgt agcggctgat ctccccctgc cgggtgccgc
     7261 gcttgatctg ttcggcgagg cgggggttgc cgaggctgtg ggcgaagtcg aggtacccgt
     7321 cgtcgtcggt gggcggcacg tggtcgctca cgccgaacag cgagcacatc cagcggtgat
     7381 gctccacggc gaggatcact cccccgcgcg gcacgccggg tgcgaaggcc atctggtagg
     7441 cgacgtcgaa gtccagctcg tcctgcggcg ggcgttcgta gcacgcagag gtgtaggtga
     7501 tcttcgcttt gatcacggac ttggcggaca ttgggatccg cgcttcgccg agccaggcgt
     7561 cgatcttcgt ggtgcgcccc gaggcgtcga cgaccaggtc ggcggtgacg tcgtccgacg
     7621 tcgctgcgcc gtccgtgcgg tagcggaccc ggtcgagtcg gccgggaacg ctcgacgtca
     7681 ccgtctcgca gcgggtcgcg gcgagcaggc gcacggcggg cagggccaac acccactggc
     7741 gcagccgccg ttcgagctcg tcgcgggtga aggtctgcac ggggacgccg accgtggtgg
     7801 tcggcgcgta gccggtcggc agcaggaagc tgatgcgctc gccgtagtcg aacacgggcg
     7861 cgccgagctc cgcgagctcg gcccgcagcc cagggaacag gcgctcaagg gcgtcaccgc
     7921 cgcgggcgag cagcgcgtgc gcgtggtagc cctgcggcac gtgcgggtgg accccggtgt
     7981 ccgcgtccat cgggtcgcgc tccaggacga gcacctcggt gaagtggtcg gcgaggactc
     8041 tcgcggtgac gagccccgcg tacccgccgc cgatgacgac ggcccggtcc cagcgggtgc
     8101 cgggcgacga actctgctgg atcttggcca tgaccggtcc cgctcctccg cgttcggctc
     8161 cccgccgctt cgacgtgcgc cacggagtat cgcgcccacc gcaccgcggc tcgaccggtt
     8221 tctgtcgcga ttgcgccgtc gcggagcacg ggctgtcgca cctcgcacac aaggggtgac
     8281 tacgtcatgg cgcccgggac cgccccacag gccacggcac ccaccggcca tcaacggctg
     8341 aatcccgtgg gtaccccggc aaacatcccc acggcgcgat catcgtatcg agttaatgtc
     8401 cgccggtttc cttggtgtgc ggggtcgtgc ggccactagt gtccctctgg atctggacgg
     8461 attcccgatg ggatacccct tttctttcca ttgccccata acgcacatgt acgcgcatgc
     8521 cttgagcaag gagagctcac ccgatgactg ttgactcgag cccggaagcg cgactggaac
     8581 ctccccggca atccagcctg ggtacggcgg ccgcccgcaa cctcgccacc accaccaagt
     8641 ccgccccgca gatgcaggag atcacctccc gctggctgct gcggatgctc ccctgggcgg
     8701 agaccaaggg cggcgcgtac cgggtgaacc gccgcctctc ctacaccgtc ggcgacggga
     8761 ccgtggagtt cgtccaggac ggcgccacgg tccgggtgat cccccgtgaa ctgggcgaac
     8821 tggccctgct gcgcggctat gacgacgtgg acgtcctcac cgccatcgcg ggacggtgcg
     8881 tccagcgcga cttccgtgcg ggtgagaccc tggtcgagcg cggcgcgccc gcggaccagc
     8941 tccatctgat cgcgcacggc cgcatcagcc agacctcgga gggcggttac ggcgacgagg
     9001 tcgacctgga cgtactcgcc gacggcgacc agttcggcga gcacgcgctc ctggacgagg
     9061 acgcccgctg ggaggtgacc gccaccgcgg agacctcggg caccctgctc accctgtcgc
     9121 gcgcggactt cgccgccgtc cggtccacgg cgcctggtct gaacgagcac ctcgaagcgt
     9181 tcacgtcacg ctcccagcgc cgacagaacc accgcggcga ggccgagatc gcgatgtcgg
     9241 cgggccacac cggcgagcac gcgctgcccg gcgcgttcgt cgactacgaa ctcaagccgc
     9301 gcgagtacga gctctcggtc gcgcagacca tcctgcggat ccacaccagg gtcgccgatc
     9361 tctacaacgg cccgatgaac cagaccaagg agcaactccg cctcaccatc gaggcgttgc
     9421 gcgagcgcca ggagcacgag ctcgtcaaca accgggagtt cggcctgctg cacaacgccg
     9481 acttcaagca gcggctccag ccgcactcgg gaccgccgac cccggacgac ctggacgagc
     9541 tgctctgcag gcgccgcggc tccaagttct tcctcgcaca ccccaagacc atcgcggcga
     9601 tcgggcgtga gttcaacgcg cgcgggatct atccggacca cgtcgacctc ggcggccagc
     9661 aggtgcccgc ctggcgcggg gtgccgatcc tgccgtgcgg caagatcccg atcacggagg
     9721 agaagaccag ctccatcctc tgcatgcgta cgggcgagga gaaccagggc gtcatcggcc
     9781 tgcaccagac agggctgccc gacgagtacg agccgggtct ctccgtgcgg ttcatgggcc
     9841 tcaacgagca ggcgatcacc tcctacctcg tcagcaccta ctactccgcc gccatcctcg
     9901 tgccggacgc ggtcggtgtc ctcgagaacg tgcagatcgc ccgctggccc aggtagcgga
     9961 tggccgccga ccatctcccc gaggagccaa ggagccatcg atgtccgcgc ctgagctgac
    10021 acctccgcag ccgagcctgc ccgaggccgc cgcccgcttc ggggcgcacg tcctcgccga
    10081 cgccgcggct cgcgcctgcg acatcaaggc cgtgaccggc acggcgccct gtgcgccggt
    10141 cgcgaccgat ccgcccacgc cgtccgtgcc ctcgccgtcc gtgcccgccc agccagagcc
    10201 gcccgccgtc tccgtgccgg cagggtccga cgtcgacctg gagcgggtcc tgcggggccc
    10261 caacggcctg ggcaccacgg ggctgcggct gaccccgcgc gacgaaccgg ccacggcggc
    10321 ggaaccgtcg gcggccgagg gcaagcccat ccccggcctc taccaccacc cggtgcccga
    10381 gcccgacccc gtgcgggtcg aggaggtcag ccggaggatc aagtcctggg cgctggacga
    10441 ggtctccctc taccccgacg actgggagga gcagttcgac ggcttctccg tgggccgcta
    10501 catggtcggc tgccatccgg acgcgcccac gatcgaccac ctgatgatcg ccacccgcct
    10561 gatggtcgcc gagaacgcgg tggacgactg ctactgcgag gaccacggcg gctcgcccat
    10621 cggcctcggc gggcgcctgc tcctggcgca caccgccctc gatccgctct acacgacggc
    10681 ggagtaccag ccgcagtggg ccgagtcgtt gcacgcggac gcgccgcggc gcgcctaccg
    10741 ctccgccatg gagtacttca ccgggacggc gagccccgcc cagtccgacc ggttccggca
    10801 cgacatggcc cggctgcacc tgggctacct cgccgaggcc gcctggtccc aggaggacca
    10861 cgtaccccag gtgtgggagt acctggcgat gcgccagttc aacaacttcc gcccctgccc
    10921 gaccatcacc gacaccgtcg gcggctacga gctgcccgcg gatctgcacg ccaggcccga
    10981 catgcagaag gtcatcggac tcgcgggaaa cgcgacgacc atcgtgaacg acctctactc
    11041 ctacaccaag gagctcgacg ctcccggccg gcacctgaac ctgcccgtcg tgatcgccga
    11101 acgagagggc ctctccgacc gggacgccta tctgaagtcg gtcgaggtcc acaacgacct
    11161 catgcacgac ttcgagaccg aagccgctgc cctggccgcc gcctgtcccg taccgaccgt
    11221 gcagcgcttc ctgcggggcg tcgccgcgtg ggtcgacggc aaccaccact ggcaccggac
    11281 caacacctat cgctacagcc tgcccgactt ctggtaggaa gaatggaatc atctgtgacc
    11341 agcaccgaac tcaccgccac cgacgccctc gtacgcatcc ccggcccggc gacgccctat
    11401 cagggggaca tcgcccgcta ctgggacggg gaagccaggc ccgtgaacct gcgtctcggc
    11461 gatgtcgacg gtctctacca ccaccactac ggcatcggtg aggtcgaccg caccgcgctc
    11521 ggcgagcccg aggacagcga gagcgagaag aagctgatcg ccgagctgca caggctggaa
    11581 tcggcacagg ccgactacct gctcgggcac ctcggcgaca tcgggcgcga cgacaccctg
    11641 gtggacgcgg gctgcgggcg cggtggctcg atggtgatgg cgcaccagcg cttcggatgc
    11701 aaggtcgaag gcgtcacgct ctcggccaag caggccgagt tcgccaaccg gcgcgcccag
    11761 gaactgcgca tccaggacca cgtccgcgcc cgcgtctgca acatgctcgc cacgcccttc
    11821 gagaccgggc aggccgcggc ctcgtggaac aacgagtcga gcatgtacgt cgacctccag
    11881 gatctgttcg ccgagcactc gcgcgtcctc aaggtcggcg ggcgctacgt gaccatcacg
    11941 ggctgctgga acccgcgtta cggccagccc tcgaagtggg tctcccagat caacgcgcac
    12001 ttcgagtgca acatccactc gcgcagggag tatctgcgcg ccatggccga caaccggctc
    12061 gtgccgcagg ccgtcgtgga cctcaccccc gacacgctgc cctactggga gctgcgggcc
    12121 acgtcctcgc tggtcacggg gatcgaggag gcgttcatca actcctacaa ggacggttcg
    12181 ttccagtacc tgctgatcgc ggccgaccgg gtctgacgtc cgctcgtgct gccggggacg
    12241 gcccgttggt caggcaacgg gccgtcccct cacggctgcg gatccgccgc cgcccgggca
    12301 tcgtcgacta cgcggggtcg ggcgcaagct gtgggcaggg accgatccac gcaccgacag
    12361 gaaggccgtg tcatgagcgt tctcgactct ccgatacccc ggttccacct ggcggtaccg
    12421 gtcgacgacc tggcggccgc gcgccgcttc tacggcgagg tgctcggcct ggagcagggc
    12481 cgcagcgcgg acacctggat cgactggaac ctccacggcc accagttcgt cacgcacctc
    12541 gcacccgggc gggcacgccc cgtccacaat ccggtcgacg ggcacgacgt ccccgtgccg
    12601 cacttcgggc tgatcctgac cgtccccgtc ttcgaggaac tcgccgggcg actgcgcgcg
    12661 gcgggcaccg acttcgtcat cgagccctac gtccgcttcg cggggcagac cggcgagcaa
    12721 cggacgatgt tcctgctcga tccggcgggc aacgcgctcg agttcaaggc cttcgcggac
    12781 gactcccagg tcttcgcctc ctgagcgaag gaccgtgccg ggggtggcgt cagcgacacc
    12841 ccccgtccgg gccccagacc tcctgtgccg cgccgcgtgc cggagcaggc ttgctcctgt
    12901 caccagcgaa cactccggcg ttcccgcgcc ggacaccgac ggcgaacagg agacgtgatg
    12961 accagccaca cgcgacgcag ggtccttcag ggggcggcgc tggccgccgc gggcagcgtg
    13021 gtcgggggct acgggctcgg cccgggcgcc accaccgcgc gggccgcggc gggcggcggt
    13081 gggaccccgg cgggcggcgc gacgtcgacg ccgttcctgg aaggggcgtt cgcgccggtc
    13141 accgaggagc tgaccgcgtt cgacctgccg gtgaccggcc gcgtgccgcg cgacctggac
    13201 ggccgctacc tgcgcacggg accgaacccg ctcggcctcg aggacccgcg ggcgcaccac
    13261 tggatgctgg gcgacggcat ggtgcacggg gtgcggctgc gcgacggacg cgccgagtgg
    13321 taccgcaacc ggtgggtgcg ctcctcgcag gtggccgaga aactgggcga gccgtacccg
    13381 ggcccggtgc cgccggacga cttcccgtgc aacacgcacg tgatcccgta caagggacgg
    13441 atcctggcgg tccaggagag cgggccgctg ccgtacgaac tggacggcga gctcggcacg
    13501 gtgcgcccgt acgacttccg cggcacgctg aagggcgcgt tcaccgcgca caccaagtac
    13561 gacgcggccg cggacgagct gcacgcggtg gcgtactacc cgacctggga ccacgtgcgg
    13621 cacatcatga tcgaccggac cgggcgggtg gcccgcaccc acaagatccc ggtgacggac
    13681 gcgccgatga tgcacgactt cgccctcacc gagaagtacg tggtgatcgt ggacgtcccc
    13741 atcacgttcg acccggcggc cgccgaggcg ggggcgatcg tgccgtacat ctggaacaag
    13801 cggcacccga tgcgcctcgg ggtcatgccg cgcaccggcg gcaccacccg gtggttcgag
    13861 atcgatccgg tgtacttctc gcacacgctc aacgcctacg accagggtga cgagttggtc
    13921 cttgagcaca tctccatgcc cgcgcccttc tacgcggcgg ggcggggcaa cggcgggccc
    13981 tcgtcgacgg gcaagccgac gctgaaccgc tggacggtcg acctgcgcgc gggccgggtg
    14041 cgcaccaccc gcatcgacga catggcgcag gagttccccc gtgtcaacga gtcgctcgtc
    14101 tcccgcaggc accgcttcgc gtacacggcg agcgcggcgg agatgtggcg cgcctacgag
    14161 acggtggacg gggtgccgcc ggacgagaag ttcaccaact gcctggtcaa gcaggacatg
    14221 ttgcgcggca gcaagcaggt gcaccgcttc cccaaggggg cgggggccag cgagccggtg
    14281 ttcgtgccac gccgcggcgc acgggacgag gacgacggct acatcctctc ctacgtgcac
    14341 gaccccgacc gcggcgcgag cgacctggtg atcctctccg cgcaggactt caaggggcac
    14401 ccgctggccc gcgtccacct gccgggacgc gtgccgctcg gcttccacgg gagctgggtg
    14461 gcggaccagt agccgaccct cgggcagtga cctcggagcg agcggcgaag taggttcggt
    14521 ccgtgctgat caaactcgcg ttacaccgcc tggcgcccca ccgctcggcg gtgtcgctga
    14581 ccgtcctgct ccaagtcgcc cagaccggcg ccctgttgtg gctgcccgcc ctcaacgccg
    14641 tgatcatcga cgagggagtg gtgcgcggcg acacgggagt gatcgttcgg gtcggcggtc
    14701 agatgctggc cctcacgctg gtccaggtcc tgtgcgcgct cggcgccctg cacttcggcg
    14761 cgcgcacggc gctggccgtg gggcgcgatc tgcgggagga cgtcttcgcc cacgtgcagc
    14821 gcctgtccgt gcaccaggtg gccaggttcg gcacgccgtc gctggtcaac aggaccacca
    14881 acgacgtact caacgtccag acgctcctgc tcaccgttct caccctgctg gtcaccgcgc
    14941 cgctgatgtg cgcgggcggc gtgatcatgg cgttcggcca ggacgtgccg ctctcctcgg
    15001 tcctgctgct cctggtcccc gtcctcgcgg tgcaggccgc gctggtcctg cggcggctgc
    15061 gtcctctggt ccggtccctc caggaactcg tcgacgacgt cacgcgcacg ctccgggagc
    15121 agatcaccgg agtgcgcgtc gtgcgggcct tcgtgcggga cgcctacgag cagcggcgct
    15181 tcgcacggtc caacgacaac ctcaccgaca tcgcgacccg ggtgggcagg atgaccacgc
    15241 tgctccttcc gctgggagcg acgacggtga atctgttcgg cgtcgcggtg gtgtggctga
    15301 gcgcgccccg gatcgaggac ggcagcatgc ggatcggggc gctgaccgcg ctgatcacct
    15361 atctcacgct gatcctcacg tcggtgatga ccgtgaccgg cctgttcatg gtgctgccgc
    15421 gcggcgaggt gagtgcggag cgcatcgccg acgtgctggg cacggaaccg gagatcgggc
    15481 cgccggcccg ggcggcggcc cggccgtccc ggccctgccg ggtggagtgg cgcggggtgg
    15541 agctcagata tccgggcgcg gaggtaccgg tgctgagcgc tctcgccctg acggcggagc
    15601 cgggcgcggt caccgcggtc atcggcccga cgggcagcgg caagaccacc ctgctcggcc
    15661 tggtcccgcg cctgttcgac gtcacggcgg ggacggtgcg cgtcggcggc caggacgtgc
    15721 gcgacctgga tccggcggtc ctcacccgca cggtggggat ggtcccgcag aaggcgtacc
    15781 tcttctccgg gacggtcgcc tccaacctcc ggtacggcag gccggacgcg tccgacgacg
    15841 acctgtggcg ggccctcgag gtcgcgcagg cccgtgactt cgtggcacgg atgccgggtc
    15901 ggctgcgggc gccgatcacc cagggcggcg gcaacgtctc cggtgggcag cgccagcgcc
    15961 tcgcgatcgc cagaacgctg gtcgccgctc ccgacgtcta cctcttcgac gacgcgttct
    16021 cggcgctcga ccagagcacc gaggccgcgc tgcgggcggc gctcgccgag gagacggccg
    16081 acgccaccgt cgtcatggtg gcgcagcgcg tgagcagcgt gcgcggcgcg gaccgcatcg
    16141 tcgtcctcga cgacggccgg gtcgtcggca ccggctccca cgaggagctg tgcgagagca
    16201 gcccgaccta ccgggcgatt gtgcgctccc agtcgccgag cggagtcgtc gcatgaggtg
    16261 gccgcggcgc acggcggccg ccgagcagca ggaggcgccg gcgcgggcgg ccgacttcca
    16321 gggcgcggct cgccgcctgc tgcgccgcgt acgacgccaa cgcgccctct tctacggcat
    16381 gttggcgctc ggcacgacca gcgtgacgct caatgtggcc gggcccaagg tcctcgcgca
    16441 cgccaccgac ctggtcgtgg cgggtctcgt cgggcggcgg ctgccggagg ggacgagcag
    16501 ggcggacgcc gtcgggcggc tgcgcgagca gggcgacgac gggctcgccg acatgctggg
    16561 cgcggtggac gtcgtgccgg ggcacggcat cgaccagggc gctctcgcgg cgaccctgag
    16621 cctcgccgtc gccgtgtacg ccctctccgg tctgtgctgg atcgcgcagg ggcgggtgac
    16681 gacccgggtg gtccagcgca cggtccgcgc cctgcgccag gacgtggcgg agaagctgtc
    16741 ccggctgccg ctctcccact tcgaccgcca gccgcgcggc gagatcctga gccgcgcgac
    16801 gaacgacatc gacaacatcg cgcagacgct ccagcagacg atcagccagc tcaccaactc
    16861 gctgctcctg gtggtcggcg tgctcggcat gatgttctgg atctcgccgc cgctggccct
    16921 ggtcgcgctg gtcacggtgc cgctcacctt cgcggtgacc gcgctgatcg cccggcgcgc
    16981 caagccgcac ttcgtgcgcc agtggagccg tacgggccgg ctcacctcgc aggtcgagga
    17041 ggagtacacg gcgcacgacc tggtgctgct gcacgggcgt cagcaggcgt ccgccgatga
    17101 gttcgcccgg cacaacgagg agctgttcca ggccggttac cgggcgcagt tcctgagcgg
    17161 cgccatccag cccgccctca ccttcatggg caacctcggc tatgtgctgg tggcggtggc
    17221 cagcggcatc cgggtcgcgt cgggtgccct gtcgatcggt gacgcccagg cgttcgtgca
    17281 gtactcgcgg cagttcggcg gcccgctgac caacgcggcc agcgtcgcca acctggcgca
    17341 gtcctgcgcg gtctcggcgg agcgcgtctt cgccctcctc gacgccccgg aagtgcgccg
    17401 gacccccacg acctcccggc cgaacggggc ccaggaggcg caaccgccgg tcgggcggct
    17461 ggacttcgag gacgtgtcct tccggtacac gcccgaggag ccgctcatcg agggcctgtc
    17521 cttgtcggtc gaaccgggac agcaggtggc cgtcgtcggc ccgacgggag cggggaagac
    17581 gactctggtc aacctcctgc cgcggttcta cgacgtcacc aagggccgca tcctgctcga
    17641 cggcgtggac atcgccgagc tgccgcacga ggaactccgg cgcgcgatcg gcatggtgcc
    17701 ccaggacgcg tggctgttcg cgggcaccat cgccgacaac atcgcgtacg gcagggaggg
    17761 cgcgacacgc accgaggtgg cggaggcggc gcgggcggcc cacgccgacc acttcgtccg
    17821 cacgctgccg gacggctacg acaccctgct cggtgacggc ggtgcggggg tcagcgccgg
    17881 tgagcggcag ctcatcacca tcgcccgcgc cttcctcgcc gacccgctgc tcctcgtgct
    17941 cgacgaggcg accagctccg tggacacgca caccgaggcc ctggtgcagc aggcgatggc
    18001 gcggctgagc gagggccgca cgagcatcgt catcgcccac cgcctcgcga cggtgcgcga
    18061 cgccgacgtg atcgtggtcc tcgaccgggg cagcgtcgtg gaacagggca cgcacgccca
    18121 actgctggcc gcggaagggg cgtacgcgcg gttgtgcgcg gcgcagctgc ggtgagggcc
    18181 gcgatctcac cccccggcga gcgcgtcgcc cggggaacgg tcccgctccg cggcgagcac
    18241 cgtctccacc acatcggccg ccgcgggtgc cccgcccgcg gcggcacagg cgcggcgcat
    18301 gcggtcgatc ccggccctga ccgccgtgtc cgaggccacc gacgccacgg cggcccggag
    18361 cacgtccgcg gtgaggtccg cgcccaccag ccaccgcccc agggcgagtt cctcgacccg
    18421 ccgggcgttc gcctcctgtt cgggacgctc gggcaccacg acgaggggca ctcccgcgtg
    18481 caccgattcc atgacggagt tcatgccgcc gtgcgagacg aaggcggtgg cgcggcgcag
    18541 gaccgcacgc tgggggaagt acggtcgcac gtcgaactcc gggggcaatg ggcccagttc
    18601 ggcggggtcg atgtgttcgc cggtggccat ggcgacgcgc tgtccggtgt cggcgaacgc
    18661 gtccctgcac agggcgaaga aaccggggcg tcgggaggcg gtgccgagcg agacgtagac
    18721 cagcggctcg tcatcggccg cggcgcacac gtcggcatcg ggggccacct ctccttccgc
    18781 gtcgagtgaa gggccgacga agtggtagcc gtcgtcgaac gtctcggccg cgaactggaa
    18841 ctcacggggg acgaacacca cgttcacctc ggcgggcggg cccgacatca ggacggaggc
    18901 catgctcacg ccgtaggtgg tggcacgtcg gcgcagcctc gcgagcaccg gccgcagggt
    18961 ggccctgtcg gggccctgcg cgccgggcac cagacccgcg cgctgggtgt ggctgttgcc
    19021 cgcgcctccc gcgcacgccc ggtggctcgc cgggaccctg cccggcgccc ggctcgctca
    19081 catacccgga atggggcatc tgttgcatcc ggcggtcacc gcccggctgg ccggggagat
    19141 cctggcgcac acggccgccg cctctggcgc ggcccggtga gcctcccccc ggcgagtcat
    19201 atcgtcgaac gggggcccgg tacctggctg cggcccccat gggcaaggat gtcggctatc
    19261 ggccgccacg gctgcgcacc agcaggtaca ggaagtacgg cgtgccgatc acggccgtca
    19321 tgaggcccgc gccgagctgg gccggggcga tcaccgtgcg gcccaccagg tcggcggtgc
    19381 acaccaggat cgcgcccagg aggacggcga ccgggaccac ccgggtgtgc tgacggccga
    19441 cgagggcgcg ggccgcgtgc ggtgcgacca ggccgacgaa gccgatcgtg cccgcggcgg
    19501 cgacggcggt ggcgctcagc aggacgctga ggacgaggaa gccgaggcgg ccccggctca
    19561 ggttcaggcc gagcagtctc ggggtgtcct cgtccaggga gaccaggtcg agttcggtgc
    19621 gccgggtgaa cgcgacggcc acgcccacgg cgaggacgat cgcgaggggc accacgtcgg
    19681 gcagggtgcg cccgtaggtc gagcccgcga gccaggtgat cgccttcgtc gcgttgaacg
    19741 ggtcggtgag gatgatcagc atgctgatga ccgcggccga tccggtggcg aggccgaagc
    19801 cgaccaggac gagccggttc tgctggaagc cgccccgtgc cgcgagcccg aagacgatga
    19861 ccgagccgat cgcggcaccg gcgaacgcgc ctcccgcgag ggtccacgac ccggccgtgg
    19921 gcacggtcgt cacgagcagg acggcccccg cagcggcggc gttggtgacg ccgagaacgc
    19981 ccggttcggc cagggggttg cgcgtcacgg cctggatgag ggtgcccgcg agggcgaggg
    20041 ccccgcccgc gaggagggcc gcggtgacgc gcggcacgcg ggtgtcgagg acgaaggaga
    20101 cggtctgccc cgccctgccc tgcgcccagt tgacgacgtc gccgaggagc agcttgctgt
    20161 cgccgatgag tacggcggcg atcatcaggc cgatcaggac ggccaccagg gcgacggtcg
    20221 tgacgacgaa ggcgccgcgg ctgcggatgc gcagccggtc ggcgggtgcg gcgcccgccg
    20281 tgtccttggc gcgcgcggcc atggtgacca ggaagacggc gccgaccagg ctggtgacga
    20341 cgccggtcgg caccgcgacc gccgtgtccg aggggacgac ggcacgcaac agcacgtcgg
    20401 agccgagcac cagggccgcg ccggtcaggc ccgcgaacgg cagccgggca cgcgagcgcg
    20461 tgaaggcgcg gaacctgcgg gcgagcgggc gtacgagggc gggggcgcac aggccgacga
    20521 agccgacggg cccggcgagg gtgacggcgg cggcggagag cagcgcggcg agcacgacgg
    20581 cgatgacgcg ggtggagcgc acgggcacgc cgacgccgtg cgcggcgtcg tcgccgaggg
    20641 ccagcgcgtc gaccctgcgg gcgagcagga tcaggccgac gaggccgatg acggcgatcg
    20701 gcagcatctg caggacgccg tcgaagccgt tctgcgcgat gctgccctgg ttccacttgt
    20761 agaggccctc ggtctcctgc gggaacagca ggagcagccc ttcggtgacg gcgagcagtc
    20821 cgagggtcag ggcgctgccc gccagcacga ggcggacggt gcccgcgccg aggccggaca
    20881 ggccgaggac cacggccgcc gcagcgaggc cgccgacgaa ggcgatgccg gaggaggcga
    20941 ggaagggcag cgagacgccg gtggcggcgg ccacgccgag cgcgaggtag gagcccgcgt
    21001 tgacagcgag ggtgtcgggc gatgccagga cgttgcggct gaccgcctgg agggcggcgc
    21061 ccgcgatgcc gagcacggcg ccgacgagca gtcctgcggt catcctcggc agccgggagg
    21121 cgacgacgac ggacgcgtcg gacgtgtcgg cgctgccggt gaacgccttc catatctctg
    21181 cggggccgac ggcggcggtg ccctgggtga tgtcgacgac cgcgagcgcg gcgacgagaa
    21241 ggagcagtgc ggccgtcacc gcggccgcgc ccgtacggga tgcggctgtc gcgggacggg
    21301 tggcgggggt ggttgcg
//
