LOCUS       NZ_CP022685            21119 bp    DNA     linear   CON 17-JAN-2024
DEFINITION  Streptomyces formicae strain KY5 chromosome, complete genome.
ACCESSION   NZ_CP022685
VERSION     NZ_CP022685.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces formicae
  ORGANISM  Streptomyces formicae
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9611874)
  AUTHORS   Holmes,N.A., Devine,R., Qin,Z., Seipke,R.F., Wilkinson,B. and
            Hutchings,M.I.
  TITLE     Complete Genome Sequence of Streptomyces formicae KY5, the
            formicamycin producer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9611874)
  AUTHORS   Holmes,N.A., Devine,R., Qin,Z., Seipke,R.F., Wilkinson,B. and
            Hutchings,M.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2017) School of Biological Sciences, University of
            East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, United
            Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.0; Newbler v. 2.3
            Assembly Name                     :: KY5 Genome
            Expected Final Version            :: yes
            Genome Coverage                   :: 56.0x
            Sequencing Technology             :: PacBio; 454; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/17/2024 10:10:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,274
            CDSs (total)                      :: 8,185
            Genes (coding)                    :: 8,082
            CDSs (with protein)               :: 8,082
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 39 of 103
            Pseudo Genes (incomplete)         :: 77 of 103
            Pseudo Genes (internal stop)      :: 11 of 103
            Pseudo Genes (multiple problems)  :: 22 of 103
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:13:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 28708
            Orig. end                         :: 49827
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022685.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Matthew Hutchings,
            University of East Anglia, UK.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21119
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21119
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21119
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11119](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11119)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            complement(179..439)
                     /locus_tag="KY5_RS41660"
                     /old_locus_tag="KY5_0025c"
     CDS             complement(179..439)
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (20-80). E-value: 1.2e-13.
                     Score: 43.1. Matches aSDomain:
                     nrpspksdomains_KY5_RS41660_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.4"
                     /locus_tag="KY5_RS41660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0025c"
                     /product="acyl carrier protein"
                     /protein_id="WP_159072439.1"
                     /sec_met_domain="PP-binding (E-value: 3.9e-12, bitscore:
                     45.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPVDEVDDWVVRQLAVLSIPPRPAEEITAQQSLTEDLGVDSLAF
                     IEALVSFEEKFGVRLDEDRLLLSSYAKVQDLADYLRDSRTS"
     aSDomain        complement(200..379)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KY5_RS41660_PP-binding.1"
                     /evalue="1.20E-13"
                     /label="KY5_RS41660_PP-binding.1"
                     /locus_tag="KY5_RS41660"
                     /protein_end="80"
                     /protein_start="20"
                     /score="43.1"
                     /tool="antismash"
                     /translation="PPRPAEEITAQQSLTEDLGVDSLAFIEALVSFEEKFGVRLDEDRL
                     LLSSYAKVQDLADYL"
     gene            complement(436..2181)
                     /locus_tag="KY5_RS00130"
                     /old_locus_tag="KY5_0026c"
     CDS             complement(436..2181)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (22-450). E-value: 9.9e-89.
                     Score: 289.7. Matches aSDomain:
                     nrpspksdomains_KY5_RS00130_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="KY5_RS00130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0026c"
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_098240207.1"
                     /sec_met_domain="AMP-binding (E-value: 5.3e-92, bitscore:
                     307.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATGESTSLAVDTPPLTIPSAFARSALARPLSPALTDGLLGLTYQ
                     QLQDETDDISRALAPLVNPGDRVALQLPRSAEYMVTYLAVLSLGATVVPLAHDLSAAET
                     DTELASCAPVLLLQDPDLRGARPHRVSAASDRGGGASATVVHVPVRARADGDLTSLRSV
                     CGAAEGAGPAPGRGANPAEPAVLLATSGSYGLPKRVVLTHSALLASARAHRASLDGATD
                     ATDATDATADATTGEGETTLAAVPLNFGYCNTVQIVGQLDSGGHVVLLDGDFLPSRFGR
                     LVQEHRVTSTLLVPSMLRLLTLGDWHRAYDLSSLRHIVYGGAPTPPEILAGIEQRLPDV
                     ELVETYGQTEAGPRVTTMRRRDRQDHPGSVGRPLPGVEVAIRDRDFRPLPPGATGEIVV
                     RGPGVMTGYHGRPEESARVLRDGWLLTGDLGRLDEDGFLYLRGRLRNVAIVSGMNVSLE
                     EVEACLTAHPAVAEAVCGVRADDRAGETLVAWVRLAADGPGAGPGEQIAAPAGQAALLQ
                     ELTGFCRERLSAHKLPRRIATVADLPRTRTGKIDRSALLARSRNVPGEPAAPGRGAPDV
                     EEAVR"
     aSDomain        complement(832..2115)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KY5_RS00130_AMP-binding.1"
                     /evalue="9.90E-89"
                     /label="KY5_RS00130_AMP-binding.1"
                     /locus_tag="KY5_RS00130"
                     /protein_end="450"
                     /protein_start="22"
                     /score="289.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ARSALARPLSPALTDGLLGLTYQQLQDETDDISRALAPLVNPGDR
                     VALQLPRSAEYMVTYLAVLSLGATVVPLAHDLSAAETDTELASCAPVLLLQDPDLRGAR
                     PHRVSAASDRGGGASATVVHVPVRARADGDLTSLRSVCGAAEGAGPAPGRGANPAEPAV
                     LLATSGSYGLPKRVVLTHSALLASARAHRASLDGATDATDATDATADATTGEGETTLAA
                     VPLNFGYCNTVQIVGQLDSGGHVVLLDGDFLPSRFGRLVQEHRVTSTLLVPSMLRLLTL
                     GDWHRAYDLSSLRHIVYGGAPTPPEILAGIEQRLPDVELVETYGQTEAGPRVTTMRRRD
                     RQDHPGSVGRPLPGVEVAIRDRDFRPLPPGATGEIVVRGPGVMTGYHGRPEESARVLRD
                     GWLLTGDLGRLDEDGFLYLRGRLRNVAIV"
     CDS_motif       complement(931..1014)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KY5_RS00130_0002"
                     /evalue="5.20E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="KY5_RS00130"
                     /protein_end="417"
                     /protein_start="389"
                     /score="34.8"
                     /tool="antismash"
                     /translation="PPGATGEIVVRGPGVMTGYHGRPEESAR"
     CDS_motif       complement(1573..1632)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KY5_RS00130_0001"
                     /evalue="2.80E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="KY5_RS00130"
                     /protein_end="203"
                     /protein_start="183"
                     /score="13.9"
                     /tool="antismash"
                     /translation="AVLLATSGSYGLPKRVVLTH"
     gene            2378..2875
                     /locus_tag="KY5_RS00135"
                     /old_locus_tag="KY5_0027"
     CDS             2378..2875
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015032117.1"
                     /locus_tag="KY5_RS00135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0027"
                     /product="hypothetical protein"
                     /protein_id="WP_098240208.1"
                     /transl_table=11
                     /translation="MTGNQGRRPSNRQLAGKISARLTHLICTLYPDERARPGYARLAKE
                     IRETTGGALSGTYLWELATGKKHNVTVEQLGVLADFFGVPPEYFFNEEVAGRVNAQLQL
                     ATALRDARVRSLALRAEGLSGETLDALLTMVDQARKLHRLPAVEEARPEDGSADAAADP
                     RS"
     gene            2980..3501
                     /locus_tag="KY5_RS41665"
                     /old_locus_tag="KY5_0028"
     CDS             2980..3501
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KY5_RS41665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KY5_0028"
                     /product="hypothetical protein"
                     /protein_id="WP_159072440.1"
                     /transl_table=11
                     /translation="MLFPYRALRQRCESVLEELALPRSASAHELCRYVARRRGRPIHLY
                     PLPAQGRTDGTCGAWIATDTDDHVFFEPGTTRPHQDHIILHEIGHILLGHHRPLTDDTE
                     PVRDVLPDLDPRLIRRLLRRASHSTRQEQEAEMVASLILSGVLRPTYLNAHGTAKTVER
                     ALGLHAASGD"
     gene            3482..4723
                     /locus_tag="KY5_RS00145"
                     /old_locus_tag="KY5_0029"
     CDS             3482..4723
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042915.1"
                     /locus_tag="KY5_RS00145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0029"
                     /product="MAB_1171c family putative transporter"
                     /protein_id="WP_098240210.1"
                     /transl_table=11
                     /translation="MLLPATDLAALGTDAQVAGTVCMWTAVLLRLPHALGSRQQRELWL
                     ACLAAAAATTLDLDGVGDFVDRNSGSAHSVDLVRNVCGLISAFALLELVHSLAAGSRSR
                     TLLRWLRVTACCVVVGAVALDTLHSPHGRHLILEGPSPTPSPPYWLLIIGTHLIANTLC
                     LAVCVRRGRRSGNRSLTAALLLLGSGTAMAGVFWLGALSQLLGSAWSVPIQPFALALHG
                     LLVAAALTVPTTRAARRALTDLGHLWRIWPLWRDLVEVCPQVLLAPRRSRLMEALWPQG
                     PRRLLLYRKLMEIRDAILVLDQYATPELHSRARAFADTVSDGVPAHPYDGDTRAAAPPA
                     EEHSAAVLAAVLKGARAAHLTGGEPRRDTPPIAPIGADTLADETTFLLTVARIYRSAPT
                     SVHPHTPVPEEAPR"
     misc_feature    3809..3811
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4720..6333
                     /locus_tag="KY5_RS00150"
                     /old_locus_tag="KY5_0030"
     CDS             4720..6333
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963661.1"
                     /locus_tag="KY5_RS00150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0030"
                     /product="MFS transporter"
                     /protein_id="WP_098240211.1"
                     /transl_table=11
                     /translation="MTTDTPPLAGRREWIGLTVLALPTLLISMDMTVLYLAVPHLSADL
                     GPSSTELLWIMDIYGFLIAGALVPAGALGDRIGRRRIMLFGAALFGIASALAAYATSPL
                     MLIVSRALLGLAGATLMPSALSLVRVMFQRAGQRSFAVAVVMTSFSVGTTIGPLLGGAL
                     LEHFWWGSVFLAGVPVMVLLLAIGPVLLPEYRDPQGGRLDWFSAALALAAVLGVVYAVK
                     HVSAAGPDLSFALTLVAGLALGVVFVRRQNHLDDPLLDLSLLRDRVINTSLGTYLLGLF
                     AMGGTQLFIALYLQEVLDLSPFMAGAWMVPASVGTIVGSLLAPLLARRFRPATVITGSL
                     LVAALGFATLSQVDGDDLALLITGYELVALGLSPMITLCTDLVISTAPPQRAGAASALS
                     ESSGEMGVALGVALLGTVGTAVYRTQLTDQLPDGLPEATADAARSALAGATEAAEPLPD
                     ALATPLLAAAHEAFASGLGVTAAAAGTIVLAAAVLAAVRLRHLPTHAQADGGRAEQGAG
                     SESDPKAGVESDAGARSDRA"
     misc_feature    6362..6379
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            6418..6963
                     /locus_tag="KY5_RS00155"
     CDS             6418..6963
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013936.4"
                     /locus_tag="KY5_RS00155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hemerythrin domain-containing protein"
                     /protein_id="WP_159072441.1"
                     /transl_table=11
                     /translation="MSNSTSLTPPSSTSEPVPDLTGMRLSHRALTGDITRLAELLASLA
                     HTDVPEPRARAVAAYIHQDNAAVRHHHHNEDDTLWPLIALSAGHTIDLTPHVDEHSALD
                     PLQDTCDEAAARWRTSAAASSTCSPATPKPRNRNSHGTTCIATRVRRMCCPARTHAALP
                     EAAAADGSMPPVAARLPP"
     misc_feature    complement(7231..7245)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.34"
                     /tool="antismash"
     gene            7807..8292
                     /locus_tag="KY5_RS42910"
     CDS             7807..8292
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015422.4"
                     /locus_tag="KY5_RS42910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helicase associated domain-containing protein"
                     /protein_id="WP_098240214.1"
                     /transl_table=11
                     /translation="MPLPSLLGDGAVRQRKRNTEPCPFRATARTNAPNTTPNCPFCPTC
                     WLLRCSRIPHGRVLAVARAPCRGPASRQGDAANVRGADPRTRNTAAQQFHAREGHLRVP
                     RKHVEGLGFDAGANSSLPGVDGPVEVRLGTWLDNVRKRAGKLSTERRADLDQLGIRW"
     gene            complement(8784..9995)
                     /locus_tag="KY5_RS00170"
                     /old_locus_tag="KY5_0032c"
     CDS             complement(8784..9995)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KY5_RS00170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KY5_0032c"
                     /product="hypothetical protein"
                     /protein_id="WP_159072442.1"
                     /transl_table=11
                     /translation="MPRTPLSGSARLALYPLHIGAPEDGLCEVGRAETGVFIALPIEGV
                     ALVEWLGQGMPLAEVGVCFEDAFGIAPELDEFLEGLWECGFIKSINGTPTATTAAGQPA
                     RGWRLFASLPAERLGWLLSRPCLIAYRAIWVALAVVLITRPGLWPHARDTLVVSGVILN
                     AVIVALLAWTMVFLHELAHLLAARARGAIGALSLSRRMYFLVAQTDMSGVRALPRAERY
                     APYLAGMTLEAGVLLGCLGLRWAGAGGGLPALLAYIVTIQLLFQCAIFLRTDLYFVLTN
                     RLRAGSLAADTTQVLRAYGRRVRGAPAIDLSHIPQRERRLVHWYLPFYAAGIAAAVVDL
                     ALFVVPAVVTMCRRALHELTTAGPLRQAEAAAFLAIVTFNLGSVAVIALWQHLGGRRRA
                     RTTA"
     gene            complement(10001..11119)
                     /locus_tag="KY5_RS00175"
                     /old_locus_tag="KY5_0033c"
     CDS             complement(10001..11119)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013094.4"
                     /locus_tag="KY5_RS00175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0033c"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_098240216.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 2.3e-13,
                     bitscore: 49.0, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 9.9e-48, bitscore: 161.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRPRVKPIFPPIPIGGGKIRIGWYDYGIAGELDDDEQGHTWHLL
                     QLLSGEHTLPEIARLMQEFDPLVRDEEVGDAVDQLAAAGYLEDAAVGPDVSLFSPPEIE
                     RYRRNVEFFSHFHHPPLSGHDFQARLRKSRIAVVGLGGLGSYAALALTAMGVGELLVVD
                     CDTVEAVNLNRQVLYTDADVGRAKTEAAVERLAQVNPHVSVTPLFLEIDGPKSAAEVFA
                     GRDLVICAADRPRVRIYEWFNAASVGAGVPWVRGGNTGLTVSLFLHAPGRTACFACVQR
                     TTHEELPWYEAASRYLAENLATGTFNPCTAPVAGLLGSIVALDTVKYLTGVAAPAALGR
                     RLLIDLARMDVAYSEEEPRRPDCLVCGDAPRR"
     aSDomain        complement(10841..11119)
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KY5_RS00175_Pantocin_Microcin_RRE.1"
                     /evalue="7.90E-16"
                     /identifier="RREFam017.1"
                     /label="KY5_RS00175"
                     /locus_tag="KY5_RS00175"
                     /protein_end="93"
                     /protein_start="0"
                     /score="49.0"
                     /tool="antismash"
                     /translation="MLRPRVKPIFPPIPIGGGKIRIGWYDYGIAGELDDDEQGHTWHLL
                     QLLSGEHTLPEIARLMQEFDPLVRDEEVGDAVDQLAAAGYLEDAAVGP"
     gene            11620..12405
                     /locus_tag="KY5_RS00180"
                     /old_locus_tag="KY5_0034"
     CDS             11620..12405
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF020897.4"
                     /locus_tag="KY5_RS00180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0034"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_098240217.1"
                     /transl_table=11
                     /translation="MAGCPYEKSHEGTRGRGVLEGAFALLEAIERTEEAGLTALTAESG
                     LPKTTVHRLLEQMVDLGVVEQSGTRYRMGPRVFRLGQGWQPHPRLRVAAHAPMRRLAEM
                     TDATVGVCVLREGRTLAVHGVPGMVDHLAPLRPGATWSWSTAAGRLLVATAPPAIPFDP
                     LPASWRREAAAIRESRLALDREELIPGVHCVAAPVTAPDGTVVAALCAMVDPAHDLRHL
                     GHAVTLAGRAVSAGLPRTARRARGSGARGVTGTRSLQRA"
     misc_feature    11779..11781
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12617..13000
                     /locus_tag="KY5_RS00185"
                     /old_locus_tag="KY5_0035"
     CDS             12617..13000
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569409.1"
                     /locus_tag="KY5_RS00185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0035"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_098240218.1"
                     /transl_table=11
                     /translation="MTAFDTAAYETAVARYFEAWNAGGDENVIKAVAAAWTEDGSYTDP
                     LADVSGHEGLAAVINGAHEQFPGFEFRRTGTVDGHHGIARFTWELVSTADGTAPVAGAD
                     VITLADDGRIRTVHGFLDRLPTA"
     gene            13138..14055
                     /locus_tag="KY5_RS00190"
                     /old_locus_tag="KY5_0036"
     CDS             13138..14055
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003957326.1"
                     /locus_tag="KY5_RS00190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0036"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_234362554.1"
                     /transl_table=11
                     /translation="MTDSLVPNEVVHEEPETGIHARMELWQVGGLGLFSTRNSGFEVRR
                     NDRHVRHHRSRPVISVSLQPEGVHRAEIAGRQQVLGPDDICVFHELSPRVYGWSGDGAS
                     QSMMFDVDRLDMPVDAVVKASLQLRASPLYDLVLNHLRGVWRDPGRLEGDPGAAALATA
                     TTELVRALLVSAAHAEESPAVRSAMDETLLTRVLAYARRHLSDRDLTPERIAREHAVSV
                     RKLYALLNDADIRLEQWLITERLARAREMLTAPRYDRLTVAAVGARCGFTSPSHFSRRF
                     QAAYGTSPSEWRRHRDVTSSDGGG"
     gene            complement(14078..15040)
                     /locus_tag="KY5_RS00195"
                     /old_locus_tag="KY5_0037c"
     CDS             complement(14078..15040)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670975.1"
                     /locus_tag="KY5_RS00195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0037c"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_234362555.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 7e-06, bitscore:
                     24.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLERHTRAFAETYACPSWPESASEPGSDDPASSRSRMAALWDGGG
                     ADDPDIEEEWLALPGRDGNRIRVRILRPAGTDEPLPVVLYLHGLGWMLTDAYAHRRLLA
                     DLVLGADAAVVVPEYDTPRDARHPHAVERAYTVARWVAGQGAECHLDGARMAVVGASAG
                     AQLAAALTLVARERGGPDFRHQVLVCPVTDAAMDTPSYRRFADGYFLSRDAMHGYWQQY
                     APDRESRAQGAVSPLRASVSRLRDLPPALVLTAEADVLRDEGEAYAARLREADVPVVSI
                     RYQGTIHGFVLFDLLRGTEASRAARIQLTDTLHAALHSA"
     misc_feature    15200..15216
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 21.78"
                     /tool="antismash"
     gene            15370..16344
                     /locus_tag="KY5_RS00200"
                     /old_locus_tag="KY5_0038"
     CDS             15370..16344
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025878.4"
                     /locus_tag="KY5_RS00200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0038"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_098240221.1"
                     /transl_table=11
                     /translation="MSVGSGTAVSPGTETSTDVESAFARWLTPLVAPGDADRRADGSVS
                     FRQFGYVRMLTCASGPLRLVRGPRPGTEDAVALLVPREAAVRLVQDGRGVSVVPGESAL
                     IDLRRAFTVEYEGAARALFLRLPLHALHVPSVPLRSLTARALPPSAGSAAVLPALLRHL
                     ETAAPRVSAPLGERLGGLVTDLVAGLVEDLAEDAEGPPEDDRHPLVVTIRQYIDRHLGD
                     PDLSAERIAAAHLISVRYLHRLFEAEGVTVGRLIQRQRVERCAGELARRGRSSPSIAVV
                     AARWGFRSPAHFSRAFKSVYGHPPQQWRRMAMSGTADAPGTRA"
     gene            complement(16353..17249)
                     /locus_tag="KY5_RS00205"
                     /old_locus_tag="KY5_0039c"
     CDS             complement(16353..17249)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1015: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670976.1"
                     /locus_tag="KY5_RS00205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0039c"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_234362556.1"
                     /transl_table=11
                     /translation="MTTTMPTPTATTGDTFADRTLGFLRIRTFRGTARPVRHVPDADAV
                     TDPYVLLGFHTAGRATLGGPGSTEVCLPGDVFLRDGARPLTLEEREDFELHLVHVPRRA
                     LALTDRQARDLAGRAPFADGTVAPLLGPLLREITAAEPGPPSRAALRWAGAVADLVALL
                     AVEDAGPGSAEDGQDREALVRRLRAYVDANLRDRNLTPATVAEAQHISIRYLHKLFEGR
                     GSTVGRWIQHRRLEEARRELARPARDDITVAAVASRWGFASATHFSRSFRTAYGMSPSD
                     WRDGRTRPAEGPGTGRR"
     gene            17380..20106
                     /locus_tag="KY5_RS00210"
                     /old_locus_tag="KY5_0040"
     CDS             17380..20106
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157438.1"
                     /locus_tag="KY5_RS00210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KY5_0040"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_098240223.1"
                     /transl_table=11
                     /translation="MGSGQGDRTLVGRRREQALLERSLDEARVGACGSATVLRGEAGIG
                     KTALLEWTVARAARDGFTVLRVVGSESESGIAFGALHRVLLPLRENSRALPPHQRLALE
                     RALGLRDELPPKGFMVGAAALALLAEQARRGPVLIVVDDLQWVDPSSAAVFVFLHQRIV
                     SLPVVMVCASRSDGSALEGWPAHPVDVEALSGEDARTLLRRRQPGLAAGAVRRVLAEAA
                     GNPLALAELPGRFADEHRRGVVPLPERLPLGSRLEEVFARRVRSLPGSAARVLLLAALD
                     DVADVGGDAVRSTEQGGAEGVLDAIEASGLARWDAAGRLVFRHPLVRSAVIAAVPDAER
                     RSAHRSLAERLREDDPRRLLHEASAAEGPDERLAARLQEAGTRIAGRGGDAEGAMLLER
                     AAALGTGPGDRARRLTWAAVMSARGGRLAYAAELLREIRRGPVPEDIAPLFAYAVVYVD
                     QSHHVDFASSFELLPGALEALTAPGAPVFGDLVEQMAFKLLLASAYTGDPRGWDVLERH
                     RGHLSPAVRLCHRAWADPPRTAHGAERELRSLVARVAARRETAGAWLLLWAASAVDAAD
                     EELRRLFDDEHTYATQGSVAKARCHQAFLRGRWDAAEECLREADTAEELGYHCNALLFR
                     HYYAHFLAGRGDERGLRDVRARIGPVATSARMRFVTDHLDRLDALAALAHGRDEEAYLL
                     LRRVMPPGQLPRGLAWFHLAFFDFVVASLRCGRRAEARAHVAAGRAARMDSVSAHHAFL
                     LAAATAITADDAEADAAYAAACAVPGAGEWVFDMARLRLLHGAGLRRRGRRAEAVDTLH
                     AALRAFQGLRADPWVEQCRAELRAADRPSNGTSVPADGLTAQELRVARLVSTGLTNKEV
                     GAALQLSPRTIGAHLYRIFPKLGVTSRAALAGALPDS"
ORIGIN
        1 gccacgaaga cggtggcgcc gcgggtccag gccgccgcga tccggtcgac ggcagcggtc
       61 acctggccgg tctcgatgcc gcgtacggcg tcgaccaaca tgcggaggta gctgtcgggt
      121 tccactgagt gctccgttct gctgggtcgc ccgggccgtc cggcgggtcg ggcggtagtc
      181 agctggtacg ggagtcgcgc agatagtcgg cgaggtcctg gaccttggcg tacgaggaaa
      241 gcagcagccg gtcctcgtcg agccgcacgc cgaacttctc ctcgaaggag acgagggcct
      301 cgatgaaggc cagcgagtcc actccgaggt cctcggtcag cgactgctgc gccgtgatct
      361 cctccgccgg gcgtggcgga atgctcagca cggccagctg gcgcacgacc cagtcgtcca
      421 cttcgtccac gggtgtcacc gcactgcctc ctcgacatcg ggcgcgcccc gaccgggcgc
      481 agctggctcc ccgggaacgt tccggctgcg ggcgagcagc gcggaccggt cgatcttgcc
      541 ggtccgggta cgcgggagat ccgccaccgt cgcgatgcgg cgcggaagct tgtgggcgct
      601 caggcgctct cggcagaagc cggtcagctc ctggaggagg gcggcttgtc cggcgggggc
      661 cgcgatctgt tcacccgggc ccgcgcccgg tccgtcggcg gccaggcgta cccaggccac
      721 cagcgtctcc cccgcgcggt cgtccgcgcg caccccgcac acggcctcgg ccaccgccgg
      781 gtgcgccgtc aggcatgcct ccacctcttc gagggagacg ttcatcccgc tcacgatggc
      841 gacgttgcgc agcctgccgc gcagatagag gaagccgtcc tcgtcgaggc ggccgagatc
      901 gccggtgagc agccagccgt cgcgcagcac ccgcgcgctc tcctcgggac ggccgtggta
      961 ccccgtcatc acgccgggcc cgcgtaccac gatctccccg gtcgcgccgg gcggcagcgg
     1021 gcggaagtcc cggtcgcgga tggccacttc gacgccgggc agcgggcgtc cgacggatcc
     1081 cgggtggtcc tggcggtcgc ggcgccgcat ggtggtgacc cgaggtccgg cctcggtctg
     1141 tccgtacgtc tcgaccaact ccacatcggg caggcgctgt tcgatgccgg ccaggatctc
     1201 gggcggggtg ggggcgccgc cgtagacgat gtgccgaagc gaggagaggt cgtacgcgcg
     1261 gtgccagtcg ccgagggtga gcagccgcag catggagggc acgagcagcg tcgaggtaac
     1321 ccggtgctcc tggacgaggc gcccgaaccg gctgggcagg aagtcgccgt cgaggagcac
     1381 gacatgcccg ccgctgtcca actgcccgac gatctgcacg gtgttgcagt agccgaagtt
     1441 cagcggcacg gcggcaagcg tggtctcccc ctcgcccgtc gtggcgtccg ccgtcgcatc
     1501 cgtcgcatcc gtcgcgtccg tcgcgccgtc tagcgaggcg cggtgcgcgc gggcgctggc
     1561 gagcagggcg ctatgggtca gcacgacgcg cttgggcagg ccgtacgagc cggaagtggc
     1621 gagcagcacg gcgggttccg ccgggttcgc gccacggccg ggagccggac cggcaccctc
     1681 cgccgccccg cagaccgacc gcagggacgt cagatcaccg tcggcccggg cgcgtacggg
     1741 aacgtgcacg accgtggccg acgcgccgcc cccgcggtcg ctcgcggcgg agacacgatg
     1801 cgggcgcgcg ccccgcaaat ccggatcttg cagcagcaac accggtgcgc aggaggcgag
     1861 ttcggtgtcg gtctccgccg cgctcaggtc atgggcgagg ggcaccacgg tggcaccgag
     1921 ggagagaacg gcgagatagg tcaccatgta ttcggcgctg cggggtagct gaagggccac
     1981 ccggtcaccg gggttcacca gaggcgccag ggcgcggctg atgtcgtccg tctcgtcctg
     2041 gagttgctgg tacgtcaggc ccaacaggcc atcggtgagc gcgggtgaca gggggcgcgc
     2101 gagggcggaa cgcgcgaacg ccgagggaat cgtcagaggt ggggtgtcaa cggcgagtga
     2161 ggtcgactca ccagtggcca caggtggatc accttcccta cacgatcagg tcgtacacta
     2221 cagcggacaa ccacaccaag aagcttacgc tgaaacgatc gcagcctgtc aacagtggcg
     2281 aacacgaagc gacttggagc gctagactgc gtccgctgca gcggacgggg gacgtcgccc
     2341 cgcttgcgga gtgacgcgtt cagccacgga ggcacacatg acgggcaacc agggcaggcg
     2401 gccatcgaac cgtcagctgg cgggcaagat cagcgcacgg ctgacccacc tcatctgcac
     2461 gctctacccg gacgaacgcg ccagacccgg ctacgcgcgc ctggccaagg agatcaggga
     2521 gaccaccggc ggcgcgctct cgggcaccta cctgtgggag ctggccaccg gcaagaagca
     2581 caacgtcacg gtcgagcaac tgggcgttct ggccgacttc ttcggcgtcc cccccgagta
     2641 cttcttcaac gaggaggtcg ctgggcgggt caacgcccag ctccaactcg ccaccgcact
     2701 gcgggacgca cgggtccgct ccctggcgct gcgcgccgaa gggctctccg gcgaaaccct
     2761 cgacgcgctg ctgaccatgg tcgaccaggc acgcaagctg caccgcctcc cggccgtcga
     2821 ggaagcgaga cccgaggacg gatcagcgga cgccgcggcc gacccccggt cgtgacgcga
     2881 tgacgaggac gaaggcgacg acgaggaccc agaagaggag gacgagaact cggcatcact
     2941 ggccagcacg acccgccgcc ccccaaagga cgagtgacct tgctgttccc ttaccgagcg
     3001 ctgcgacagc ggtgcgaatc agtccttgag gagctcgcgc tgccccgatc cgcctcggca
     3061 cacgaactgt gccgatacgt cgcgcggcgg cgcggccgcc ccatccatct ctatccgctg
     3121 cccgcccaag gccgcaccga cggcacctgc ggcgcgtgga tcgccaccga caccgacgac
     3181 cacgtcttct tcgaaccggg caccacccgc ccccaccaag accacatcat cctgcacgag
     3241 atcggccaca tactcctcgg ccaccaccgc cccctgaccg acgacaccga gccggtgcgc
     3301 gatgttctcc cagacctcga cccccgcctg atccggcggc tgttgcgccg cgcctcgcac
     3361 agcacgcgcc aggaacagga ggccgagatg gtcgcgagcc tgatcctcag cggagtgctg
     3421 cgcccgacgt acctcaacgc ccacggcacg gcgaagacgg tggaaagggc gctggggctc
     3481 catgctgctt ccggcgactg acctcgcggc ccttggcacc gacgcgcagg tcgcgggcac
     3541 ggtatgcatg tggacggccg tgctccttcg cctgccgcac gctctgggct cacgccagca
     3601 gcgcgaactg tggctggcct gcttggctgc ggcagccgcc acgacgctcg acctggacgg
     3661 cgtcggcgac ttcgtcgacc ggaactccgg cagcgcgcac agcgtggacc tggtccgcaa
     3721 cgtatgcggc ctcatctcgg cgttcgcgct gcttgaactg gtccactcgc tcgcggcggg
     3781 ctcccggagc cggacgctgc tccgctggtt acgggtcacc gcgtgctgcg tcgtggtggg
     3841 cgccgtcgcc ctggacacgc tgcacagccc ccacggacgg cacctcatcc tcgaaggccc
     3901 ctcccccaca ccctccccgc cgtactggct gctgatcatc ggcacacacc tgatcgccaa
     3961 caccctgtgc ctcgcggtgt gcgtacgccg cgggcggcgc agcggcaacc gctccttgac
     4021 ggccgccctg ctcctgctcg gatccggcac cgccatggcg ggcgtgttct ggctcggcgc
     4081 gctgtcccaa ctcctcggct ccgcctggtc ggtgcccata caacccttcg ccctggcgct
     4141 gcacggtctg ctcgtcgcgg cggccctgac cgtccccacc acccgcgccg cccgccgcgc
     4201 gctcaccgac ctcggacacc tgtggcggat ctggccgctc tggcgcgacc tggtggaggt
     4261 gtgtccgcag gtgctgctcg caccccggcg cagccgcctc atggaggccc tgtggccaca
     4321 gggcccgcgc cgcctcctgc tgtaccgcaa gctcatggag atccgtgacg ccatcctcgt
     4381 gctcgaccag tacgccaccc ccgaactgca ctcccgcgcc cgggcgttcg cggacaccgt
     4441 gagcgacggc gtcccggcac acccgtacga cggtgacacg cgcgcggcgg cgccaccggc
     4501 cgaggaacac tcggccgccg tactcgccgc cgtcctcaaa ggcgcccgcg cggcccacct
     4561 gaccggcggg gaaccgcgac gcgacacccc gcccatcgcg ccgatcggcg ccgacaccct
     4621 ggccgacgag acgacgttcc tgctcacggt ggcccggatc taccgatcgg cccccacctc
     4681 tgtccacccg cacacccccg taccagagga agcaccacga tgaccaccga cacccctccc
     4741 ctcgccggcc gacgggagtg gatcggactc accgtcctgg ccctgccgac gctgctgatc
     4801 tccatggaca tgaccgtcct gtatctggcg gtaccgcacc tgagcgccga cctggggccg
     4861 agctccaccg aactcctgtg gatcatggac atctacggat tcctgatcgc cggagccctg
     4921 gtgcccgcag gcgccctcgg tgaccgcatc ggccgcaggc gcatcatgct cttcggcgcc
     4981 gcgctcttcg gcatcgcctc ggcactcgcc gcctacgcca ccagcccgct catgctcatc
     5041 gtctcccgcg cgctgctcgg cctggccggg gccaccctga tgccgtccgc cctctccctg
     5101 gtccgcgtca tgttccaacg ggccggccaa cgcagcttcg cggtggccgt cgtcatgacg
     5161 agcttctccg tcggcaccac catcggaccg ctgctcggcg gcgcgctcct ggagcacttc
     5221 tggtggggct cggtcttcct cgcgggcgtg ccggtgatgg tgctgctgct cgccatcggc
     5281 cccgtcctgc tgcccgagta ccgcgacccg caaggcgggc gcctcgactg gttcagcgcc
     5341 gcactcgccc tggccgccgt gctcggcgtc gtctacgcgg taaaacacgt cagcgccgcg
     5401 ggccccgacc tgtccttcgc cttgaccctg gtggccggac tggccctcgg tgtggtcttc
     5461 gtacggcgcc agaaccacct ggacgacccg ctgctcgacc tgtccctgct gcgcgaccgc
     5521 gtcatcaaca cctcgttggg cacctacctg ctgggcctgt tcgcgatggg cggcacccag
     5581 ctcttcatcg ccctctacct tcaagaagtc ctcgacctct cccccttcat ggccggtgcc
     5641 tggatggtcc ccgcctccgt gggcaccatc gtcggctccc tgctcgcccc gctgctcgcg
     5701 cggcgctttc gccccgcgac ggtcatcacg ggcagcctcc tggtggcggc gctcggcttc
     5761 gccaccctct cccaagtcga cggggacgac ctggcgttgc tcatcaccgg ctatgaactc
     5821 gtggccctcg gcctgagccc gatgatcacc ctctgcacgg acctggtcat cagcaccgca
     5881 ccgccccagc gcgccggagc ggcctccgcc ctctcggaga gcagcggcga aatgggcgtg
     5941 gccctcggcg tcgccctgct cggcacggtc ggcaccgccg tctaccgcac ccagctcacc
     6001 gaccagctgc ccgacggcct gcccgaggcg accgcggacg ccgcccgctc cgccctcgcc
     6061 ggggcgacgg aggctgccga gcccctgccc gacgccctcg ccaccccgct cctcgcggcg
     6121 gcccacgagg cgttcgccag cggcctcggc gtcaccgccg cggcggccgg cacgatcgtc
     6181 ctcgccgccg ccgtcctcgc cgcggtacgc ctgcgccatc tgcccacgca cgcgcaggcc
     6241 gacgggggcc gcgccgaaca gggggccgga tcggagtcgg atccgaaggc cggtgtggag
     6301 agcgacgcgg gggcgcgctc ggacagagcc tgaccagctc ggtccggtcg tctcaaggag
     6361 taatcgcgtt gagtggatgg tcaccgcgcg tggagcgggc tcggagagcc tggcgccatg
     6421 tccaacagca catccctcac gcctccttcc agcacgtccg agccggtgcc cgatctcacc
     6481 ggtatgcggc tgagccaccg cgccctcacc ggcgacatca cgcggctcgc cgagctcctc
     6541 gcctcgctcg cccacaccga cgtaccggag ccccgcgccc gcgccgtcgc ggcgtacatc
     6601 catcaggaca acgccgccgt acggcatcac caccacaacg aggacgacac cctctggccg
     6661 ctcatcgccc tctccgcggg gcatacgatc gacctcacgc cccacgtcga cgagcacagc
     6721 gccctcgatc cgctccagga cacctgcgac gaagccgcgg cccgctggag gaccagcgca
     6781 gcggcgtcat cgacgtgctc tccggcgacg ccaaagcctc ggaaccggaa cagccacggc
     6841 accacctgca tagccacccg cgtgaggcgg atgtgctgcc cggcccgcac gcacgcagct
     6901 cttccagaag cggctgctgc tgatgggtca atgcctccag tcgctgcgcg tcttcctccc
     6961 taaccacagt gcggcacccg ggacgtgtgg gacttggtga acgaggtcag gcgttcttgg
     7021 atgctgcggg tctgtgtgag tcgttggatg gtcccagaag tcccgcgtcg ccatggctgg
     7081 ccctggttgt cccggaagag caaggccgtc accccgaatt cacggttccg ctccaccccc
     7141 tctttgaggg catccagctg aatggtcatc aaggtgcagg gcgggaccga ctctgcggta
     7201 gcggcgctgt acttctccct gccaaccccg ccccacgtgt tgcggggata cgtggtgatc
     7261 tccacggccc agaccggtat ggggtcgggc gagcggttca tgatgaggac cttcttggcc
     7321 ctggtctcaa acggcatgag ctcagggttg gcatcagtcc agacagagac acgcgcggcc
     7381 tggcgggcct gggcagcttg gcgttcagcg gctgcatccg cccgctggtc ctgaagggtc
     7441 tgcagcgctg cccatgaggc agcaccactg atcacaagcc ctccagccgc agcgagggcc
     7501 gcaccgaaag tcccccacga cgtaagccat tccgtcgcag gggcctgctg ctgtcgcatc
     7561 gccttacgac gttgtcggat gcggtccggc cgcggccgtc gccgcgccag gcgtgtcctg
     7621 cgctcgcgat ctgttcgccc cactggcccc tgcccccttc gctggcgtgc taccgacgga
     7681 ttgaagggac agcacagccc cggtgcatgg tggtgaccag cgggtgcagg gcgggggctg
     7741 gtggccccct cgcggcaaac gaggggccct ctcccggact gggatcccgc gtcggggcac
     7801 tgcgatgtgc ccctgccctc cctattgggc gacggggcgg tcaggcaacg caagcggaat
     7861 acggaacctt gccctttccg ggccacggcg cgcactaacg caccaaacac gacgccaaat
     7921 tgcccgttct gccccacctg ttggctcttg cgttgttccc ggatccccca tgggcgagtc
     7981 ctggcggttg cccgcgctcc atgccggggc ccggcttctc gacaggggga cgcggcaaac
     8041 gtccgaggag ctgacccacg gactcggaac actgccgcgc agcagttcca tgcccgggaa
     8101 ggacacctgc gcgtcccccg taaacacgtg gagggcctcg ggttcgatgc cggggcgaac
     8161 agctccctcc cgggcgtgga cgggccggta gaggtgcggt tggggacgtg gctcgacaac
     8221 gtccggaaac gcgccggcaa actcagtaca gaacgccggg ccgacctcga ccaactcggc
     8281 atacgctggt gaagagcgcg gcggccgaac tcagtttgag gcgcccggat atcctgcgcg
     8341 gcctgggatc gcgtgcggtt tcccggtgca gcgcttcgga ccaggcgggg accgtgtgtt
     8401 ccgcggtgtt cgccagtggc acacccggtc tttcgtccct ggccggcagg tggtgcggtc
     8461 catctgcccg ggcatccaag ccggcccaca gcacaccctc gggcagcacg ccctcggggg
     8521 gagcgagcgg gcgtctcggc gtcgtgggcg agatcaaggg cgagggctgt cttgccgatg
     8581 tctggcagcg tgcagtgtca gggtgcccgt gctgccgcag cccgcggata cgggcgtgca
     8641 gcgcctccgc gtcggggcgg gcctccgggc tccgggctcc gggctccggc acgagcccgg
     8701 ggttgtcagg gacggcaggg atccggcgcg cgcgtgttcg gggtgtttcc gcgtgccgcg
     8761 agcggtgcgg cgatgcggtt ggctcaggcg gttgtgcggg cccggcggcg gccgccgagg
     8821 tgctgccaca gggcgatgac ggcgacggag cccaggttga acgtgacgat cgccaagaac
     8881 gcggcggcct cggcctggcg cagggggcct gcggtggtga gttcgtgaag ggcgcggcgg
     8941 cacatcgtga cgaccgcggg gacgacgaac agagcgaggt ccaccacagc cgccgcgatg
     9001 cccgcggcgt agaagggcag gtaccagtgc acgaggcggc gttcccgctg cgggatatgg
     9061 ctgaggtcga tcgcgggggc gccccgcaca cgccgcccgt acgcgcgcag cacctgtgtg
     9121 gtgtccgccg cgaggctgcc cgcgcgcagc cggttcgtga gcacgaagta gaggtcggtg
     9181 cgcaagaaga tggcgcactg gaaaagcagt tggatggtga cgatgtaggc caggagcgcg
     9241 ggcaggccac cgcccgcgcc tgcccagcgc agccccagac agccgagcag cacgcccgcc
     9301 tccagcgtca tgcccgccag gtatggggcg tagcgctcgg cacgtggcag agcccgcacc
     9361 ccgctcatgt ccgtctgggc caccaggaag tacatgcggc ggctcagtga gagagcaccg
     9421 atggctcccc gggcgcgggc ggccagaagg tgggccagct cgtgcaggaa gaccatggtc
     9481 caggccagca gagccacgat caccgcgttg aggatcaccc ccgacaccac gagggtgtcc
     9541 ctggcgtgcg gccacaggcc cggacgtgtg atcaggacga cggcgagagc cacccaaatc
     9601 gcccggtagg cgatcagaca gggccgggac agaagccagc cgagccgttc agcgggcaag
     9661 gaggcgaaaa gccgccagcc ccgggccggc tgcccggctg cggtcgttgc cgtgggcgtg
     9721 ccgttgatgc tcttgatgaa gccgcattcc cagagccctt caaggaactc gtccaactcg
     9781 ggcgcgatac cgaaggcgtc ctcgaaacac acccccacct cagccagcgg catcccctgg
     9841 cccagccact cgaccagcgc gacaccctct ataggcagcg cgatgaacac ccccgtctcg
     9901 gcacggccca cctcacacaa gccgtcctcc ggcgcgccga tatgcagcgg atacaacgcg
     9961 agacgcgcgc tgccggagag cggtgtcctg ggcatccccc tcaccgccgc ggtgcgtcgc
    10021 cgcacaccag acagtccggc cgccgcggtt cctcttcgct gtaagcgaca tccatacggg
    10081 caagatcgat caacaaacgc cgacccaaag cggccggggc ggccacaccc gtcaggtact
    10141 tgaccgtgtc cagggccacg atgctgccga gcaggccggc caccggggcc gtgcaggggt
    10201 tgaacgtgcc cgtcgccagg ttctccgcca gatatcgcga ggccgcctcg taccagggaa
    10261 gctcctcgtg ggtggtgcgc tgcacacacg cgaaacacgc ggtacgaccc ggggcatgca
    10321 ggaacaaact gaccgtcaaa cccgtgttac caccacgcac ccagggcaca ccagccccca
    10381 ccgaggcagc gttgaaccat tcgtagatcc gcacccgtgg ccggtcagcc gcgcagatca
    10441 ccaggtcgcg cccggcgaac acctcggcgg cgctcttggg cccgtcgatc tccaggaaca
    10501 gcggcgtgac ggacacatgg ggattcacct gggcgagccg ttcgaccgcc gcctccgtct
    10561 tcgcccgccc cacatcggcg tccgtgtaga gcacctgccg gttcaggttg accgcttcca
    10621 ccgtgtcgca gtccacgacg agcagttcac cgacccccat ggccgtgaga gcgagagcag
    10681 cgtacgagcc gaggccgccg aggcccacca ccgcgatccg ggacttcctc aaacgcgcct
    10741 ggaagtcgtg gccggacaac ggcggatggt ggaaatgcga gaagaactcg acgttgcggc
    10801 ggtaacgctc aatctccggc ggagaaaaga gcgacacatc agggcccacg gccgcatcct
    10861 ccaaataccc cgcggcggcc agctgatcaa ccgcatcgcc gacctcctcg tcccgcacca
    10921 gcgggtcgaa ctcttgcatg agccgggcaa tctcaggaag cgtgtgctcg ccactgagca
    10981 actgcagcag gtgccaggtg tggccctgct cgtcgtcatc gagttcgccg gcgattccgt
    11041 agtcgtacca gccgatgcgg atctttccgc ctccgatggg aatgggcggg aatatgggtt
    11101 tgacgcgggg ccgcaacatc caagcctgct ttcgagaagg aacggtgagt gcgcgaaggg
    11161 tgaggacatg gagaggaatg aacgggtgcg ccgctgcgcg agccgaggct gttccggtgc
    11221 ggaggctaag gagccgcctc cgcaccggaa cgccgtgctg gaatcagcag tcacacgggt
    11281 cacacgtcgg ctgagtggtc tcgatcttct cgagacgacg gatcgcaatc ttcatcacat
    11341 accccctctc gatctctcgg tctcttgatc tcgcgttgct ccccggagag ttcactcgtc
    11401 gccggacggc gccgagacgg gtgctcgtcc tccggagtgc tcccgggcgg atcgacactg
    11461 caccgcgcag acacgtgttg tcgcgctgcg gtctgctgag cggaccggca tcggcaactc
    11521 cgctatgcgg caagcgacta tttagtggcc attcatgcgg atggctttta ctgccctggg
    11581 ggagaggcaa cgcgcaagcg acctcgggaa gggggcctga tggccggttg tccgtacgag
    11641 aagtcccatg aggggacccg ggggcgcggg gtactcgaag gggcatttgc cctcctcgaa
    11701 gccatcgagc ggaccgagga agcgggactg accgctttga cagcggaaag cggtttgcca
    11761 aaaaccaccg tgcaccgttt attggaacaa atggtcgacc tcggcgtcgt tgaacagagc
    11821 ggcacgcgct atcggatggg cccgcgggtc ttccgcctcg gccaggggtg gcaaccccac
    11881 ccacggctgc gggtcgcggc gcacgccccg atgcggcgcc tggcggagat gaccgacgcc
    11941 acggtggggg tctgcgtcct gcgcgagggc cggaccctcg ccgtgcacgg agtgcccggc
    12001 atggtggacc atctggcacc gctgcggccc ggcgcgacct ggtcgtggtc caccgccgcg
    12061 ggcaggctcc tggtggcgac cgccccgccg gccattccgt tcgacccgtt gccagcatcc
    12121 tggcgccgcg aggctgccgc catccgggaa agccgactgg ccctggaccg ggaggagttg
    12181 ataccgggcg tgcactgtgt cgcggcgccg gtgacggcac ccgacggcac ggtcgtcgcc
    12241 gcgctgtgcg ccatggtcga ccccgcgcac gacctgcggc acctgggcca cgcggtcacc
    12301 ctcgcgggac gggccgtcag cgccggactg ccccgcacgg cgcgccgagc gcgaggctct
    12361 ggggcacgcg gcgtcaccgg gacgagatcc ctgcagcgtg cttgacgaac tcatcgatca
    12421 tgcggcgcgc gtctgccgtg ggctgctcgt ggcctcaaga acccgtgcgt ctcgacatcc
    12481 cgtgcgtttc ggcatcccgc gcgtcagggg cgtcgcgctc atgacctgcg aggtaatcga
    12541 cccctctgcg ggcgagcggc agtcttgagc catcaccccg caggacgacc accacctcac
    12601 aggaggctga cccgccatga ccgcattcga caccgccgcg tacgagaccg cagtcgcccg
    12661 ctacttcgag gcctggaacg ccgggggcga cgagaacgtc atcaaggctg tggccgccgc
    12721 ctggaccgag gacggcagct acaccgaccc gctggccgac gtctccgggc acgagggcct
    12781 cgccgccgtg atcaacgggg cccacgagca gttccccggc ttcgagttcc gccggaccgg
    12841 cacggtcgac gggcaccacg gcatcgctcg cttcacctgg gagctcgtgt cgaccgcgga
    12901 cggaaccgca cccgttgccg gggccgacgt catcacgctg gccgacgacg gccggatccg
    12961 taccgtccac ggattcctcg accgcctccc cacagcctga acgtacccgg tcaagtaccc
    13021 ctcccccatg aggcagaatg tctgcttcat gggggaagtc gtcttggggg ttgtgtgctg
    13081 ctcgtcgatc tgtccaccgt ggcgccacgc gagcgggcgg acgcgtttca tcatgcgttg
    13141 accgactcgc tggtgcccaa tgaagtggtc cacgaggagc cggagacggg catccacgcg
    13201 cgcatggagc tgtggcaggt gggcgggctc gggctgttct ccacccgcaa ttcgggcttc
    13261 gaggtacgcc gcaacgaccg gcacgtgcgc catcaccgca gtcggcccgt gatctcggtt
    13321 tcgctccagc ccgaaggcgt ccaccgggcc gagatcgcgg gcaggcagca ggtcctcggg
    13381 ccggacgaca tctgtgtgtt ccacgagttg tcgccccggg tctacggctg gtcgggcgac
    13441 ggcgcgtccc agtccatgat gttcgacgtg gaccgtctgg acatgccggt ggacgccgtg
    13501 gtgaaggcct cgctgcagtt gcgcgccagt cccctgtacg acttggtcct gaaccatctg
    13561 cgcggtgtct ggcgcgatcc ggggcgtctt gagggcgacc ccggcgccgc agccctcgcc
    13621 acggccacca ccgagctcgt ccgcgcgctg ctcgtctccg ccgcgcacgc cgaggagtcc
    13681 cccgccgtcc gctcggcgat ggacgagacg ctgctcacgc gggtcctggc gtacgcccgc
    13741 cgccacctct ccgaccgcga cctgacgccg gagcggatcg cgcgggagca cgccgtctcg
    13801 gtgcgcaagc tctacgccct gctcaacgac gcggacatca gactggagca gtggctcatc
    13861 accgagcgtc tggccagggc gcgcgagatg ctgaccgcgc cccgctacga ccggctcacc
    13921 gtcgcggcgg tgggcgcgcg gtgcgggttc accagcccga gtcacttcag ccgccgcttc
    13981 caggcggcgt acggcacgtc ccccagcgag tggcgccgac accgcgacgt cacgagctcc
    14041 gacggcggcg ggtgaggggc atccgtcccg gccgggctca cgccgagtgc aaggcggcgt
    14101 gcagtgtgtc cgtcagctgg atgcgggccg cccgggacgc ctcggtcccg cggagcaggt
    14161 cgaagagcac gaagccgtgg atggtgccct ggtagcggat cgacacgacg ggcacgtccg
    14221 cttcccgcag ccgggccgcg tacgcctcgc cctcgtcgcg gagcacgtcg gcctcggccg
    14281 tcaggaccag cgccggaggc agatcgcgca gtcggctcac cgatgcgcgc agcggcgaga
    14341 cggcaccctg cgctcggctc tcgcggtccg gcgcgtactg ctgccagtag ccgtgcatgg
    14401 cgtcgcggct gaggaagtat ccgtcggcga accgccggta ggacggggtg tccatcgccg
    14461 cgtccgtcac cgggcagaca aggacctggt ggcggaagtc cgggccgccg cgctcgcgcg
    14521 ccacgagcgt gagggctgcg gccagttggg cgcccgcgct ggcgccgacg accgccatcc
    14581 tggccccgtc caggtggcac tccgcgccct gccccgcgac ccagcgggcc accgtgtagg
    14641 cgcgctccac ggcgtgcggg tggcgggcgt cccgcggggt gtcgtactcg gggacgacca
    14701 cggcggcatc ggcgccgagc acgaggtcgg caagcagtcg ccggtgcgcg tacgcgtcgg
    14761 tcagcatcca gccgaggccg tgcaggtaca gcacgaccgg cagcggttcg tcggtgccgg
    14821 ccgggcgcag gatccgtacc ctgatgcggt tcccgtcgcg ccccggcagc gccagccact
    14881 cttcctcgat gtccgggtcg tccgcgccgc cgccgtccca cagggcggcc atgcgggacc
    14941 tggacgaggc cgggtcgtcg gacccgggct cggacgcgga ctcgggccag gagggacagg
    15001 cgtacgtttc ggcgaaggcc ctcgtgtgcc gttcgagcac aggtctctcc ccgacgactg
    15061 gaacgtctgc ttccacgggg actcctgcac aggggacgga tcgcggggcc gttcgcggct
    15121 ccgccgactc ggagtactca ccctaggacg ccatcggccg gaaaggggac cggcggtccc
    15181 actgattcat gccgctgcgt gcacacttcg ggcgcagcct ctgacgcgta cgcgaaaggc
    15241 agtcatatga cctaacgcct cacgcggttg tcggtccaga ctcacggtca tgggccgtgg
    15301 accaggggtg accgtccccc tctgccacgc acagggcacc ggcccgggga cggttgaagg
    15361 gagccctccg tgagcgtggg atccggaacg gccgtgtcgc cgggcaccga gacctcgacc
    15421 gacgtggagt ccgccttcgc gcgctggctc acacccctcg tggcacccgg cgacgccgac
    15481 agacgggcgg acgggtccgt gtccttccgg cagttcggct acgtccgcat gctgacctgc
    15541 gcgtcggggc cgctgcggct ggtccgcggt ccccgcccgg gcacggagga cgcggtcgcg
    15601 ctgctcgtcc cgcgcgaggc ggcggtgcgg ctggtccagg acgggcgcgg cgtgtccgtg
    15661 gtgccgggtg agtcggcgct catcgacctg cgccgcgcgt tcaccgtcga gtacgagggc
    15721 gcggcccgcg cgctcttcct tcggctgccc ctgcacgcgc tgcacgttcc ctcggtcccc
    15781 ctgcggtccc tcacggctcg cgcgctcccg ccgtccgcgg gctccgcggc ggttctcccc
    15841 gccctgctcc ggcacttgga gaccgcggcc ccgcgggtgt ccgccccgct gggcgaacgg
    15901 ctcggcggtc tcgtcacgga tctggtcgcc gggctcgtcg aggacctcgc cgaggacgcg
    15961 gaagggccgc ccgaggacga caggcacccc ttggtcgtca ccatccgcca gtacatcgac
    16021 cgtcacctcg gcgacccgga cctatccgca gaacgcatcg ccgcggcgca cctcatctcg
    16081 gtccgctatc tgcaccgcct cttcgaggcc gagggcgtca ccgtagggag gctgatccag
    16141 cgtcagcgcg tcgagcggtg cgccggggag ctcgcgcggc gcggccggag cagtccgtcc
    16201 atcgccgtgg tcgccgcccg ctggggcttt cgcagtccgg cgcacttcag ccgcgcgttc
    16261 aagtccgtct acggccatcc gcctcagcag tggcggcgga tggctatgtc cgggacggcc
    16321 gacgctccgg ggacgcgtgc ctgacgatgc tgtcagcggc ggccggttcc cggcccttcg
    16381 gcgggtctgg tccggccgtc gcgccagtcg ctgggcgaca tgccgtatgc cgtacggaaa
    16441 ctgcggctga agtgggtggc actggcgaat ccccagcgac tggcgaccgc cgccaccgtg
    16501 atgtcgtcgc gtgccggacg ggccagctcg cggcgggcct cctccaggcg gcggtgctgg
    16561 atccaccggc cgaccgtgct cccccgcccc tcgaagagct tgtgcagata gcggatcgag
    16621 atgtgctggg cctcggcgac ggtggccggt gtcaggttgc ggtcgcgcag gttagcgtcg
    16681 acgtacgccc gcagtctgcg gaccagggcc tcgcggtcct gtccgtcctc tgcggagccg
    16741 ggtcctgcgt cctcgacggc gagcagcgcg acgaggtcgg cgaccgcccc ggcccagcgc
    16801 agcgcggcgc gtgacggggg cccgggttcc gccgcggtga tctcgcgcag gagcgggccg
    16861 agcaacggcg ccacggttcc gtcggcgaac ggggcccgtc ctgccaggtc gcgcgcctgc
    16921 cggtcggtga gggccagggc acggcgcggg acgtgcacca ggtgcagttc gaagtcctcc
    16981 ctctcctcca gggtgagggg acgcgccccg tcacggagga agacgtctcc gggcaggcag
    17041 acctcggtgc tgccgggccc gccgagcgtg gcccgcccgg cggtgtggaa gcccagcagg
    17101 acgtacgggt cggtcacggc gtccgcgtcg ggaacgtgcc ggaccgggcg cgccgttccc
    17161 cggaacgtgc ggatgcggag gaagccgagc gtgcggtctg cgaaggtgtc ccccgtggtg
    17221 gcggtggggg tgggcatggt cgttgtcacg tgatcagcct gctgtggtcg ggcccggctg
    17281 acgagagcgt gcggccttcc ctgcgggcag gggcacgagc cgtgcacgca caggcatcgc
    17341 ggcgatgtca cggtggtcgg aggcgaccag gggagagtca tgggcagcgg acagggtgac
    17401 aggacgctcg tcggccgtcg gcgcgaacag gcgctgctgg agcggtccct cgatgaggcg
    17461 cgcgtcgggg cgtgcggttc ggcgacggtg ttgcgcggcg aagcgggcat cgggaagacg
    17521 gcgctgctgg agtggacggt cgcgcgcgcg gcgcgcgacg ggttcaccgt cctgcgtgtg
    17581 gtgggcagcg agtcggagtc cggcatcgcc ttcggcgcgc tgcaccgagt gctgctgccg
    17641 ctgcgggaaa actcgcgtgc gctgcctccg caccagcggc tcgccctgga acgggcgctg
    17701 gggctgcgcg acgagctgcc gccgaagggg ttcatggtgg gcgctgccgc gctggcgctg
    17761 ctcgccgaac aggcgcgtcg cggcccggtg ctgatcgtcg tcgacgacct tcagtgggtg
    17821 gatccttcca gcgccgccgt cttcgtcttc ctgcaccagc ggatcgtctc tctgcccgtg
    17881 gtgatggtgt gcgcgagccg gtccgacggg tccgctctgg agggctggcc cgcccatccg
    17941 gtggatgtcg aggcgctgtc gggcgaggac gcgcggacgc tgctgcggcg ccgacagccg
    18001 gggctcgccg ccggtgccgt ccggcgggtg ctcgcggagg ccgctggcaa ccctctcgcc
    18061 ctggccgagt tgcccggtcg gtttgcggac gagcatcgca ggggcgtcgt accgctcccg
    18121 gagcggctgc cgttgggcag ccgtctggag gaggtgttcg cgcggcgggt gcggtcgctg
    18181 cccgggagtg cggcgcgcgt cctgctgctc gccgcgctgg acgacgtggc ggacgtcggt
    18241 ggcgatgccg tgcgctcgac ggaacaaggc ggcgccgaag gggttctgga cgcgatcgag
    18301 gcgagcgggc tcgcccgctg ggacgccgcg ggacggctgg tcttccgcca tcccctggtg
    18361 cggagcgccg tgatcgccgc cgtcccggac gccgaacggc ggtccgcgca ccggtcgttg
    18421 gctgagcggc tgcgcgagga cgacccacgt cggctcctgc acgaggcgtc cgccgccgag
    18481 ggccccgacg aacggctggc cgcccggctc caggaggccg gcacccgcat cgcggggcgc
    18541 ggtggtgacg cggagggcgc catgctcctc gagcgcgcgg ccgctctcgg gaccggtccc
    18601 ggcgaccgcg cgcgtcgtct gacgtgggcc gccgtgatgt cggcgcgggg cgggcggctc
    18661 gcgtacgcgg cggaactcct gagggaaatc cggcgcggcc cggtgccgga ggacatcgct
    18721 ccgctcttcg cctacgcggt cgtgtacgtc gaccagagcc accacgtgga cttcgcctcg
    18781 tccttcgagc tgctgcccgg ggcgctggag gcgctgacgg cgccgggcgc gccggtcttc
    18841 ggtgacctcg tcgagcagat ggcgttcaag ctgctgctcg cgtcggccta cacgggtgac
    18901 ccgcgcggct gggacgtcct tgagcggcat cgcgggcacc tctcccccgc cgtacgcctg
    18961 tgccaccgcg cgtgggcgga cccgccgcgc acggcgcacg gcgcggagag ggaactgcgg
    19021 tccctggtgg cgcgcgtcgc ggcccggcgg gagaccgccg gagcctggct gctgctctgg
    19081 gcggcgtcgg cggtggacgc ggccgacgag gagctgcggc ggctcttcga cgacgagcac
    19141 acgtacgcca cccaggggtc cgtcgcgaag gcgcggtgcc atcaggcgtt cctgcggggc
    19201 cgttgggacg ccgccgagga gtgtctgcgc gaggccgaca ccgcggagga gctcgggtat
    19261 cactgcaacg ccctgctctt ccggcactat tacgcgcact tcctggcggg ccggggcgac
    19321 gagcggggcc tgcgcgacgt gcgggcgcgg atcgggccgg tggcgacgtc ggcacggatg
    19381 cggttcgtca cggaccacct ggaccgtctg gacgcgctcg ccgcactggc gcacgggcgg
    19441 gacgaggagg cgtacctcct gctgcgtcgc gtcatgccgc cgggtcaact gccgcgcggc
    19501 ctcgcgtggt tccacctcgc gttcttcgac ttcgtcgtgg cgagcctgcg ctgcggccgc
    19561 cgggcggagg cgcgggccca cgtcgcggcg gggcgggccg cgcggatgga ctccgtctcc
    19621 gcgcaccacg ccttcctgct ggcggccgcg accgccatca cggcggacga cgcggaggcg
    19681 gacgcggcgt acgcggcggc ctgcgcggtg ccgggagccg gtgagtgggt cttcgacatg
    19741 gcgcgcctgc gactgctgca cggggctggg ctgcgccgtc ggggccgccg cgccgaggcg
    19801 gtcgacacgc tgcacgccgc cctccgtgcc ttccaggggc tgcgcgcgga tccgtgggtg
    19861 gagcagtgcc gggcagagct tcgggccgcg gaccgcccgt cgaacggcac gagcgtcccc
    19921 gccgacgggc tgaccgcgca ggagttgcgc gtcgcccgcc tggtgtccac cggcctcacg
    19981 aacaaggagg tcggcgcggc tctccagctg tcgccgcgca cgatcggggc tcatctctac
    20041 cggatcttcc cgaagttggg ggtcacgtca cgggcggctc ttgcgggggc gctgccggat
    20101 tcctgagaga ggcgtccagg gcgcgtgcga ttcccgccct ggtggtgatg tcgagcttgg
    20161 ggaagattcg gtagaggtgc gcgccgatcg tcctcgggga gagcgagagc cgcgcgccga
    20221 tctgccggtt ggtgaggcct cgggccgcga gccgggctat ccgtgtctcc tgcgccgtga
    20281 gcagcgggtg gtgcccggaa gtcctgcctg cggcctcgat gtccgcgtcc gccgcggcga
    20341 gttcgcggga ggcccgcgcg acccagggcg tggcgtccag gcgggtgaag gcggtgagcg
    20401 cggcacggca gtgcgcgctc gcctcctggg tcctgtgctg tcggcgcagc cgcacggcgt
    20461 gcgccaggtg ggccctggcc agcgggaagg gccagttctc cgcgtcccgc tgggcgtaca
    20521 cggccgcgtg ccgctcgtcc gcctcgtcgt cggtggcggc gatggcctcg gcaacggtca
    20581 ccagaaaggt gtggtgcgcc gagatgcggg cgaggccgga cgcgcggacc gcccgcagat
    20641 ggcgccgggc ctcctcggtc cgtccgctgt cgacggcggc ttgtacccgg tcgacgagcg
    20701 agagatgtgt ccaggggccg cggtccgtca ccgcaccggg cgtaatgagg tcgcaggcgt
    20761 ggagccacgc ctcctcggcg tccccgtggc cgagcgcgca cagcgtccgc atcccgctca
    20821 gcaggtcggt gaccagacgc agacggcgtt ctcccgcgcg ggtgccgagc gccggttcca
    20881 gtgcggtgag ccccgcccgg tccccgcggg cggcgaggat gtgtccctcg gtctgcaaga
    20941 acagcgtctc ggccagcgcg tagccgtgtt ccgcggacgt tcgcgcaccg gcgcgggcgg
    21001 cggccagggc ggtgtcccag ttcccgtgca ggaagtcgtc gtgggcccgg aggctgtccg
    21061 tgaacgtctg ggtggagtac gcgtggcggc gggcgaacgc gctccagagc gcgcagtgc
//
