LOCUS       NZ_NUEG01000051        23912 bp    DNA     linear   CON 30-JUL-2024
DEFINITION  Bacillus wiedmannii strain AFS005864
            AFS005864_61_A10_Contig56_140312, whole genome shotgun sequence.
ACCESSION   NZ_NUEG01000051
VERSION     NZ_NUEG01000051.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus wiedmannii
  ORGANISM  Bacillus wiedmannii
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 45476)
  AUTHORS   Bleich,R.M., Kirk,G.J., Santa Maria,K.C., Allen,S.E., Farag,S.,
            Shank,E.A. and Bowers,A.
  CONSRTM   Agbiome Team Llc
  TITLE     Large-scale bioinformatics analysis of Bacillus genomes uncovers
            conserved roles of natural products in bacterial physiology
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 45476)
  AUTHORS   Bleich,R.M., Kirk,G.J., Santa Maria,K.C., Allen,S.E., Farag,S.,
            Shank,E.A. and Bowers,A.
  CONSRTM   Agbiome Team Llc
  TITLE     Direct Submission
  JOURNAL   Submitted (07-SEP-2017) Chemical Biology and Medicinal Chemistry,
            UNC Chapel Hill, 125 Mason Farm Rd., Chapel Hill, NC 17599, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: CLC Assembly Cell v. 4.2.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 37.62x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002555855.1-RS_2024_07_30
            Annotation Date                   :: 07/30/2024 04:09:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,628
            CDSs (total)                      :: 5,554
            Genes (coding)                    :: 5,373
            CDSs (with protein)               :: 5,373
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 181
            CDSs (without protein)            :: 181
            Pseudo Genes (ambiguous residues) :: 0 of 181
            Pseudo Genes (frameshifted)       :: 56 of 181
            Pseudo Genes (incomplete)         :: 126 of 181
            Pseudo Genes (internal stop)      :: 39 of 181
            Pseudo Genes (multiple problems)  :: 35 of 181
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:21:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 20302
            Orig. end                         :: 44214
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            NUEG01000051.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23912
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..23912
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23912
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13912](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13912
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    366..380
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.08"
                     /tool="antismash"
     gene            671..1849
                     /locus_tag="CN905_RS25730"
                     /old_locus_tag="CN905_25735"
     CDS             671..1849
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000832387.1"
                     /locus_tag="CN905_RS25730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25735"
                     /product="glycosyltransferase"
                     /protein_id="WP_098086152.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.9e-31,
                     bitscore: 100.5, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVLFMVSSMNIGGVEKSLLSLLSVIPKEKYDVTVLMLEKRGGF
                     LKQLPSWVKIEEVTWFENIKPKIMQPPKKTINEYFENTRYIKGLNFLLTYVVSKKLKDR
                     YIFYKEIFKDIPYNKNKYDIAIAYQGPTDIIDYYIVNRVASEKKISWIHFDVFQHQINT
                     KLYEKLYDQLDNIYVVSKEAQKHLIEKFPKVESKTSVFLNIVLPDLINEMAKEKVEFDN
                     GYKGIKIVTVGRLSKEKGQDLAIKVLSMLRKEGYEVRWYCIGEGEDREYYETLICKYNL
                     KQDFLLLGSAINPYPYVNQSDIYVQTSRHEGYCLTLAEAKCLKKPIVTTNFTGAYEQIK
                     DGYNGFVAECNEESLYYKIKYLLDQQRVREEITTNLLEEEFNNLEKVNRFLS"
     gene            1872..2840
                     /locus_tag="CN905_RS25735"
                     /old_locus_tag="CN905_25740"
     CDS             1872..2840
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001068408.1"
                     /locus_tag="CN905_RS25735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25740"
                     /product="glycosyltransferase"
                     /protein_id="WP_097918160.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 4.3e-41,
                     bitscore: 132.1, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPKISIIVPIYKVEQYIHKCIDSILKQTFKEFELILVDDGSPDS
                     CGEICEGYATQDSRIKVIHKENSGLSSARNAGLEIAQGDYIGFVDSDDWIEVDMYELLY
                     GMCVEQDCDIAICSSEIHYNDKTVISSNHPFVIHDRYSAMKAMLEGNLYDEVVWTKLFK
                     RQLLEDIKFPVGMSYEDTAFTYKVIHKCNKVCFIGEPKYHYIKRDNSMMDQAVKEIKID
                     SVLIYDEMCKFMERYYKELYNLVILKLGNCSMVVLNLISLSGRLNEHKSKYYKVIGILN
                     RYFYKTMRLKEYGKSVKFLLLATKLHPLLYKFLINNFAKRG"
     gene            2914..4452
                     /locus_tag="CN905_RS25740"
                     /old_locus_tag="CN905_25745"
     CDS             2914..4452
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002137803.1"
                     /locus_tag="CN905_RS25740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25745"
                     /product="lipopolysaccharide biosynthesis protein"
                     /protein_id="WP_098086154.1"
                     /sec_met_domain="Polysacc_synt (E-value: 1.7e-16, bitscore:
                     51.9, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTMHSIKNISISIFSQIVIVILGFISRKVFLDSLGIEYLGIDGL
                     LINVLSMLVLIEAGIGASIVYNLYKPLAENNQYKIIALVQLYKKIYQILAIIILVISAM
                     IYPFLSYLMKEGASISNVAIIYSIFVVKNVVTYLNAHKRSLIQADQRGYILARMDLLFQ
                     VLTTIFKIFILIYTKDYILYLIIELSIYVIQNVVNGRIVNKNYPYIKTKKKYSIDNDTK
                     EKLIINVKAMFLHNIGGYIVFGTDNILISSFVGLAMVGIYSNYTMIINQLAAVVNPILN
                     GIEASVGNLIATENNDKNYAIFKVTYLVNFWIFSFCTIFLFNLLEPFIGWWLDKKYLLN
                     NIVFVVILINFYLTGMRTAIAIFKNKAGLFVQDKYIPLVEAIINLSLSILLANMFGLVG
                     IFIGTAISTIATVLWIQPYIVYRNLFKKSVWKYFTTYVFYVFLTVVTGFITTSICNYFI
                     EGSTFISLVEKGLICLLVPNVIYVLIFYKSTEFQYIRNIFSMMFLQIKKKRNVI"
     misc_feature    complement(4595..4612)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 24.35"
                     /tool="antismash"
     gene            4717..7047
                     /locus_tag="CN905_RS25745"
                     /old_locus_tag="CN905_25750"
     CDS             4717..7047
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002137802.1"
                     /locus_tag="CN905_RS25745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25750"
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_098086155.1"
                     /transl_table=11
                     /translation="MAKFQVTCVLKGNLPVLSEGEFCFCIDTCELFIGTKKGNVKVSTE
                     NKFERLVSKLKSNTFGSSKSRKSLIEETESANVVSGTYFLELERWNVKNDGTDAENTSK
                     GINNALSWASQQGFIEVVLPMGTYLIDENTPIEPQSFMTLNLGGSTLKIRSNGLFKYAI
                     VRYQRNQKFSRITNGRVEGDKDTHDYTTIPHTHEWGYGIEVGNTTPAEGSNMNYISIDN
                     MEILNCTGDGIAMESTWGQIGEYDFAGTFEVGGISDVDGSLIVDDNKIRSNLKIDLHHS
                     SIIKWGYFGLYGDGYGGTGSEIYTELYDVLFYRADNTFVTAVKRVKFFEEVSVPKEADY
                     AKIVLNQGEIPKENGCKITVRIPEFSRNVFIEKCKIHDCRRLGVSVSGAKQIYIRDCEI
                     YKMKGTAPQGAIDIEDGYRLNQYINIERNNIYDNQGYNVVVVGGRYINIIQNKLANNSL
                     VVGENVEKVIINNNHLREVSCVLSGEVTFTNNQMYATRVTIDQGDKEALIGNCIFHNSA
                     LLMGRDKAYCIQVNQCEFFSDRDLFHSFSQLGSIIGFSAEPQTISNCVIKGGAVEGTSL
                     TGVSPGMKNGWRLNNISFIDTKHPQGIITNLPPGVYTGCKFENSGTISFVTKTPQAEYE
                     FNGCSFSWDAYNLFTVESSQRISMLKVKNSNFRGGRWGSAFFLWDIGGRIEFSNNAFEY
                     LNSESTDSIINFWNETFTSEFMLIESNIFRSNKNMIGLNANQISSSITLIFKDNIVDTV
                     VIKLRDEHIKKDNYINGVFDPYM"
     gene            7293..7907
                     /locus_tag="CN905_RS25750"
                     /old_locus_tag="CN905_25755"
     CDS             7293..7907
                     /EC_number="2.7.8.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146: sugar transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002199623.1"
                     /locus_tag="CN905_RS25750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25755"
                     /product="sugar transferase"
                     /protein_id="WP_097994461.1"
                     /sec_met_domain="Bac_transf (E-value: 7.6e-69, bitscore:
                     222.3, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIFDVCISLLLLFVCLLPILVVAILVRMKLGSPVLFKQQRPGL
                     HGKPFNVYKFRTMLDKKDSDGELLPDKNRLTTFGEILRKYSLDELPQLINVVRGDLSLV
                     GPRPLLMEYLPLYSSKQAKRHNVKPGITGWAQINGRNLITWEEKFELDVWYVENRSFLL
                     DLKIIVLTILKVFKTEGINHIGHVTMERFTGGKIEIKGEGK"
     gene            7904..8536
                     /locus_tag="CN905_RS25755"
                     /old_locus_tag="CN905_25760"
     CDS             7904..8536
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002167803.1"
                     /locus_tag="CN905_RS25755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25760"
                     /product="acetyltransferase"
                     /protein_id="WP_000697621.1"
                     /transl_table=11
                     /translation="MKILIIGCGGHSKVVRDIILSNKGYEIVGYLDDLYTGINIVDNLY
                     FGAIADAREIINNFNDVKLVIAIGNNKIRREIAEILNQQSSIYATLIHKTAIISSNAYI
                     GNGTVIMPNVVVNADTFIGNHTIINTGSIIEHDNIIDDFVHISPHATLTGSVTIAEGAH
                     IGASATIIPGVQIGKWSIVGAGSVVINDFPSNCTAAGIPAKVINVVN"
     gene            8553..9710
                     /locus_tag="CN905_RS25760"
                     /old_locus_tag="CN905_25765"
     CDS             8553..9710
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (39-164). E-value:
                     2.4e-08. Score: 25.4. Matches aSDomain:
                     nrpspksdomains_CN905_RS25760_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000972894.1"
                     /locus_tag="CN905_RS25760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25765"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_046958084.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.2e-97,
                     bitscore: 318.0, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.8e-08, bitscore:
                     25.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKNKEKIYLSSPHMSGNEQKYIKDAFDSNWIAPLGPNVDEFERE
                     LASFVGVKGGAAVSSGTAAIHLALRLLDVQKGDTVFCSSFTFVASANPIVYLGAEPVFI
                     DSEPETWNMSPQALAFALHDANKAGKLPKAVILVHLYGQSAKVDEILSLCNQYDVPIIE
                     DAAESLGSTYKGKASGTFGRFGIYSFNGNKIITTSGGGMLVSDDVEELERARFLATQAK
                     DPAPHYEHSEVGYNYRMSNILAGIGRGQLEVLEDRVKARRSIYKRYYEALSFIPGFYFM
                     PELENTRSNRWLTTLTIDEKESGISIGKVLRILAEENIEARPTWKPLHIQSLFKRKKYY
                     PHSKNEDVSQHLFQSGVCLPSGSNMLVEDQQRVIQGVLKALEGKK"
     aSDomain        8670..9044
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CN905_RS25760_Aminotran_1_2.1"
                     /evalue="2.40E-08"
                     /label="CN905_RS25760_Aminotran_1_2.1"
                     /locus_tag="CN905_RS25760"
                     /protein_end="164"
                     /protein_start="39"
                     /score="25.4"
                     /tool="antismash"
                     /translation="DEFERELASFVGVKGGAAVSSGTAAIHLALRLLDVQKGDTVFCSS
                     FTFVASANPIVYLGAEPVFIDSEPETWNMSPQALAFALHDANKAGKLPKAVILVHLYGQ
                     SAKVDEILSLCNQYDVPIIED"
     misc_feature    9747..9760
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.98"
                     /tool="antismash"
     gene            10001..11995
                     /locus_tag="CN905_RS25765"
                     /old_locus_tag="CN905_25770"
     CDS             10001..11995
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002199626.1"
                     /locus_tag="CN905_RS25765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25770"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_098086157.1"
                     /sec_met_domain="GATase_7 (E-value: 9.3e-23, bitscore:
                     72.0, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 4.7e-25, bitscore:
                     80.4, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAITGIIHFNNELVSIEHGTRLMGDLQKYPADDIQIWRKENAFL
                     GCHAQWITPESVGEQLPFYNYEKQLVITADAIIDNRDELFEKLQVDYADRKNMTDSELI
                     LLSYEKWGEAAPKYLVGDFAFMIWDEKKQILFGARDFSGSRTLYFYRSENKFAFCTIIK
                     PLFTLPYVEKTLNEQWIAEFLAIPVNFESVDPQLTVYKYIEQVPPSHTVLVKDGKVEFS
                     RYYIPTAGKMLNLKSNEEYEEAFREVYQSAVKARLRTHHEVGAHLSGGLDSGSVVSFAA
                     KDLRAENKKLHTFSYVPVEGFEDWTHKGRIADERPFIQSTVGHVGNIQDYYLALPERSP
                     LSEIDDWLETMEMPYKFFENTFWLSGVYEKASQHEIGVLLSGQRGNWTVSWGPMLDYQA
                     MLLKKLHWIRFYRELHLYSRNLGVKKARVFEVVRRKAFPYLFQLLSSEEQDVFPIIINP
                     EFAKKMNVFDRLKEQDVDITGTSSATAYDMKREQFEKPYYWSINGTYETKLSLRYALWD
                     RDPTNDLRIIQFCLSVPEEQYVQNGLDRSLIRRATKNFLPDKVRLNQRVRGVQGADGVY
                     RMTPFWNEFIEEVQELSVDPIISEFLNVEVIKKAISKICKEPRPEYAFDLDFRILMRSL
                     IFYRFIKKFNMKGGDTYEKGMETTCIRST"
     gene            11955..12080
                     /locus_tag="CN905_RS29150"
     CDS             11955..12080
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002172970.1"
                     /locus_tag="CN905_RS29150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="paeninodin family lasso peptide"
                     /protein_id="WP_016086744.1"
                     /transl_table=11
                     /translation="MKKEWKQPVLEVLNINMTMAGPGHKIPDAVQPDPDDPVKYS"
     gene            12160..13131
                     /locus_tag="CN905_RS25770"
                     /old_locus_tag="CN905_25775"
     CDS             12160..13131
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016108921.1"
                     /locus_tag="CN905_RS25770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25775"
                     /product="aldolase"
                     /protein_id="WP_046957689.1"
                     /transl_table=11
                     /translation="MIDSRGNVLYKAFGLKIVSEIPLPELSQLNEKKEMADIQIEMTDL
                     SERWSGYNEEQQRTIVVEDDVVMFHVPQTAIFSVQAGEKITFSPMPEAKEDKIRLYILG
                     TCMGALLMQRKLLPLHGSVIAIDGKAYALIGDSGAGKSTLASAFLNAGYQLLSDDVVAV
                     SLLDKNTTVVHPSYAQQKLWQESINELGMEVAQFSPLFERETKYAVPVNSQFFPDPLPL
                     AGVIELVKTQGEDIEMIRIEGLTRLYKLYQHTFRNSLISKLGLMEWHFETSSNIASGME
                     MFQLRRPDSKFTAHELVQVILNTIQKGSMVDGCSFEKHIIRT"
     gene            13094..13402
                     /locus_tag="CN905_RS25775"
                     /old_locus_tag="CN905_25780"
     CDS             13094..13402
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128586.1"
                     /locus_tag="CN905_RS25775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25780"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_046957690.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.5e-28,
                     bitscore: 90.3, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.2e-17, bitscore: 54.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVHSRNISLEHNVVQSEGNIVSDMDGEKVMLNVQKGNYYNLGEI
                     GGEIWERIEKPIKINQLVTMLVSNYDIERKDCEEQVLSFLECLFQEGLIQIEDQSNR"
     aSDomain        13133..13381
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CN905_RS25775_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="9.30E-29"
                     /identifier="RREFam002.1"
                     /label="CN905_RS25775"
                     /locus_tag="CN905_RS25775"
                     /protein_end="96"
                     /protein_start="13"
                     /score="90.3"
                     /tool="antismash"
                     /translation="VVQSEGNIVSDMDGEKVMLNVQKGNYYNLGEIGGEIWERIEKPIK
                     INQLVTMLVSNYDIERKDCEEQVLSFLECLFQEGLIQI"
     gene            13439..13912
                     /locus_tag="CN905_RS25780"
                     /old_locus_tag="CN905_25785"
     CDS             13439..13912
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012261438.1"
                     /locus_tag="CN905_RS25780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25785"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_046957691.1"
                     /sec_met_domain="PF13471 (E-value: 2.6e-25, bitscore: 80.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIVKRLRAFLSLNMETKLLFLEAFIFLGWARVLKSITFSKVAPS
                     LGDYMNETSVAQIQPHGDTLKKVSEAISIMSRYTFWESQCLVKAIAGMKMLEKRHIEST
                     LYLGTAKDSHGELIAHAWLRSGSFYVTGSEGMEKFTVVGSFAKRLSEDIIKGE"
     gene            13914..15101
                     /locus_tag="CN905_RS25785"
                     /old_locus_tag="CN905_25790"
     CDS             13914..15101
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000409755.1"
                     /locus_tag="CN905_RS25785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25790"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_046957692.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 1.2e-66, bitscore:
                     216.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKDFGLDVEFMSKELKLLFAILKLQDDETVQTYSNEWFSDIDWE
                     VFLEQAVHHRIYPVIYQKLKQVDEELIPSHIVQTLNRKYKKNTFHMLYLSAEMERINKL
                     CNENEIRMIFLKGPVLSQDLYGDISLRTSCDLDVLIPMRNLEKVEMLLLEQGYVKDDYI
                     QTILNDWKWRHHHITFFHPTKQIKLEIHWRLNPGPGKEPGFEELWKRKRKSTLTSNSVY
                     MLGKEDLFLFLVSHGARHGWSRLRWLVDIKKIVGQDLNWNEIHKLMRKYQVLHLGGQAL
                     ILASQLLGVRLDERMTELVAKKQSKQLAQEALFYFKKMINLHSEPVPEEVRSYHSRHLF
                     SLMSNQQKIIFILSQLYPYPIDEKTLPLPKFLHFLYFPLRPFLCLWRKTKKLALL"
     gene            15113..16912
                     /locus_tag="CN905_RS25790"
                     /old_locus_tag="CN905_25795"
     CDS             15113..16912
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016096316.1"
                     /locus_tag="CN905_RS25790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25795"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_046957693.1"
                     /transl_table=11
                     /translation="MNHIIYFMKKLYSSAGKILYVNLFGMVLISLLEGIGIVLLIPMIS
                     MTGIINIDEETTFIAPVSRFLQDFPKTTSLASILGIYILIVLGQNLLQRNITLRDARTQ
                     QAFVRELRIETYSMILKAKWSFFLEKRKTNLINILTTELARVSYGVNLILQLLAAILFT
                     FIQVGIAFLLSPQITIFVLVFGLLFLVASRVFIKKARILGGKTSELAKNYLSGITDHFN
                     GIKDIKSNTLESSRIDWLQSITEKMSNEQMEYMRIRSSSQLFYKVSMAILIACFLLLSV
                     SMFQAQSTQLLLIILIFSRLWPRFMTIQSNLEQLAASIPAFKSLWELQEECKEAIEMQD
                     IHQQKYIKPICIEQGIECKDVHFRYNKQESLYALQNINVQIPINSMTAIVGHSGAGKST
                     LIDVLMGLIQPEKGQVLIDGTPLTTDNLLSLRRAISYVPQDPFLFNASIRNNLLMIEPN
                     ASEEEIWDALSFAAAAEFVQTLPNGLDTLIGDRGVRLSGGERQRLVLARAILRKPSILV
                     LDEATSALDTENEVKIQSAIERLKGTMTIVVIAHRLSTIRNADQVIVLGKGEIVQKGEF
                     NQLAKERKGVFRSLLGAQMEVGS"
     gene            17141..17464
                     /locus_tag="CN905_RS25795"
                     /old_locus_tag="CN905_25800"
     CDS             17141..17464
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016105867.1"
                     /locus_tag="CN905_RS25795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25800"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_046957694.1"
                     /transl_table=11
                     /translation="MNVQFKKGVLELCVLALVKRKDCYGYELVQQISNKFLISEGSVYP
                     LLRRLTKEGYFQTYLKESTEGPPRKYYQLTEQGETQLKLLVTEWRDFAKGVQEIIEGVE
                     WDE"
     gene            17457..17999
                     /locus_tag="CN905_RS25800"
                     /old_locus_tag="CN905_25805"
     CDS             17457..17999
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031379.1"
                     /locus_tag="CN905_RS25800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25805"
                     /product="DUF1700 domain-containing protein"
                     /protein_id="WP_046957695.1"
                     /transl_table=11
                     /translation="MSKEQFLKELSSHLRKLPEEERKDILFDYEEHFQFGIEEGKTESE
                     IIKGLGSPKVIAKDLLALYRFDEMKKDPSTTNITRAVMAAIGLSLFNFIIVLGPLVAII
                     AFIFSFWLGGIASVVTPFFVIGKVFMGTFIWLDLFVSITFVGVGLLLCIIAYYSTKWFK
                     KLCVRYVIWNFKMIKGE"
     gene            18000..18812
                     /locus_tag="CN905_RS25805"
                     /old_locus_tag="CN905_25810"
     CDS             18000..18812
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016718262.1"
                     /locus_tag="CN905_RS25805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25810"
                     /product="DUF4097 family beta strand repeat-containing
                     protein"
                     /protein_id="WP_098086158.1"
                     /transl_table=11
                     /translation="MMKKILLVAIACIIIGVIGISQTYEKAVQTAEEGNKEDVIKNETL
                     KNIEVKLDAGDIVVQKSPDSSFYVKQSGDVRKHEVRIAEDGDTLKIIGEREKGASFDFS
                     FYDFRFQTSTITLLVPERSYQEIKINSSAGQIEISDVKSDCVSVGTLAGEVDLKNVTAR
                     SVEGSSKASEVSFKKVIGKVTAKSASGEVHIMDHDPKSKYDVEASSTAGDVDITLLEKP
                     QDAVITGQSAAGEVMIFNEENKNITIGNGSKKISGKTAAGDVTIETRS"
     gene            complement(18901..19521)
                     /gene="lexA"
                     /locus_tag="CN905_RS25810"
                     /old_locus_tag="CN905_25815"
     CDS             complement(18901..19521)
                     /EC_number="3.4.21.88"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="lexA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413738.1"
                     /locus_tag="CN905_RS25810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25815"
                     /product="transcriptional repressor LexA"
                     /protein_id="WP_046958085.1"
                     /transl_table=11
                     /translation="MEKLTKRQQDILDFIKLKVQEKGYPPSVREIGQAVGLASSSTVHG
                     HLSRLEEKGYIRRDPTKPRAIEILGDNRMDTETQSVIQVPIVGKVTAGLPITAIESVED
                     HFPLPASIVAGADQVFMLRISGDSMIEAGIFDGDLVVVRQQQSAYNGEIVVALTEDNEA
                     TVKRFYKEKDHFRLQPENSSLEPIILKQVSVIGKVIGVYRDLH"
     misc_feature    19589..19602
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 22.42"
                     /tool="antismash"
     gene            19663..20319
                     /locus_tag="CN905_RS25815"
                     /old_locus_tag="CN905_25820"
     CDS             19663..20319
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016111193.1"
                     /locus_tag="CN905_RS25815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25820"
                     /product="recombinase family protein"
                     /protein_id="WP_046956545.1"
                     /transl_table=11
                     /translation="MNAIIYARVSTTKEEQETSLLRQKDELLHLAERYQMNVVKVIEEQ
                     ASGYTIERDGILEVLDTIRDEQVDVLLIQDETRLGRGNAKIALMHCLHKEGIKVYTHTH
                     NGELELSDSDSMVLDIIGIVEEYQRKIHNLKIKRGMQRAVEKGFRPENNLKNRHLSIGR
                     EKKEVPIEEIVRLRRNELTFEEIAATLRGFGHDVSKATVHRRYVEYTKQLLDKED"
     gene            20365..20604
                     /locus_tag="CN905_RS25820"
                     /old_locus_tag="CN905_25825"
     CDS             20365..20604
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002172959.1"
                     /locus_tag="CN905_RS25820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25825"
                     /product="DUF896 domain-containing protein"
                     /protein_id="WP_001190582.1"
                     /transl_table=11
                     /translation="MQSHELIERINFLAKKAKAEGLTEEEQRERQSLREQYLKGFRQNM
                     LNELKGIKVVNEEGTDVTPAKLKALKKQDNAKLN"
     misc_feature    20366..20376
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            complement(20644..22227)
                     /locus_tag="CN905_RS25825"
                     /old_locus_tag="CN905_25830"
     CDS             complement(20644..22227)
                     /GO_function="GO:0008253 - 5'-nucleotidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002199635.1"
                     /locus_tag="CN905_RS25825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25830"
                     /product="bifunctional UDP-sugar hydrolase/5'-nucleotidase"
                     /protein_id="WP_098086160.1"
                     /transl_table=11
                     /translation="MNPNQIVTLNILLTSDIHGTVYPIHYQDNSQAEIGLAKISTLIKK
                     ERSQNRNVLLIDNGDFIQGTPFTYHYATYEEDKKNPMSLLANYLRYDAAVIGNHEFNYG
                     MDILNNAISTANFPYLSANILDKNRKEPYFGKPYIIKHIESNIKIAILGMTTHYIPNWE
                     QPHHIQDLQFEDALETTKRWVSYIREHEKPDLLVVAYHGGFERDLQTGVPTEVLTGENQ
                     GYAMCHEIEGIDILLTGHQHREIAHTVMNGVTILQIGCNGHSVGKVTVTFEKTEKKWVK
                     KESYSQLLPVQGIEADQDILSLVADYEEKTQNWLDQPIGVIYGDMQISDAMQTRLQDHP
                     FIEFINKIQMDIANVSISCTSLFHNTSPGFPNRVTMRDIVSNYIYPNTLKVIRITGADI
                     KDALELSASYFILKADGTIIVNPTYIEPKPQHYNYDMWEGISYVLNISKPIGERVESLQ
                     YKGAPLHMNEEYDVVMNNYRASGGGNFFMFQNKPVIKDIPTDMSELIANYILKHKNIEA
                     TVNNNWKVIK"
     misc_feature    22185..22202
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.33"
                     /tool="antismash"
     gene            22412..23350
                     /locus_tag="CN905_RS25830"
                     /old_locus_tag="CN905_25835"
     CDS             22412..23350
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000913375.1"
                     /locus_tag="CN905_RS25830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CN905_25835"
                     /product="phosphate/phosphite/phosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_000915072.1"
                     /transl_table=11
                     /translation="MLKKVFAMSTTVVLAAGLLSGCGTKESSASKTEDTKKGYVPKTLN
                     VQFVPSQNADTLEAKAKPLEKLLSDKLNIPVKVSISTNYNTIVEAMASKQVDVGFLPPT
                     AYVLAHEKKAANVILQAQRFGVDDETGAPTKDLVDFYKSEFVVKKDSNINSVKDLKGKK
                     IGYQDVTSSAGYVWPAAVLLKEGIDPLKDVKPVTLKGHDQSLIALLNGDVDASVVFQDA
                     RNIVKKDYPNIFDQTKIVKFTEKIPNDTISVRSDLDAEWSKKLQDAFIEIGKNEEGHKI
                     IKEVYSHEGYVKSDDSKFDIVREYGKKVKTQ"
ORIGIN
        1 attttgaggg agtaagaatc cttactgttg gtagattgag tatagagaag ggacaggatt
       61 taacaatatc tgtgttagct aagctgaaag aagctggcta caatgttaaa tggtattgta
      121 taggagatgg aaaggaaaga ggaatgtatg aaaagcttgt gaaaaattac gatgttcaag
      181 gtgattatat atttttagga gcagtttcga atccctatcc atttatgaaa caatgtgata
      241 tatatgtaca accgtctcga catgagggat actgtataac acttgcagaa gccagatgtt
      301 ttaataatcc aattattagt acaaatttta caggggcaag tgaacagata atcgataacc
      361 acaatggatt aatcgttcaa tttgacgagc agcaaatgta tgattctatt gtacaaatat
      421 taagtgataa atcgctggaa ggacggttga gaaaaaatat agaaaaggaa gtggtagata
      481 cgagagaaga gttaaaaaag ttatataaaa tagcaaattc taatgtgtaa cttgttttag
      541 aaggtattat tatcgtatta cagaaatatg gacggttcat tattataaat tatgtttttt
      601 gtgaaaacat ctttgagagg gtgttttttt attttgttat aaaactttta ggtggtagaa
      661 ggagacaggt atgaagagag tgctatttat ggtaagtagt atgaatatag gtggtgtaga
      721 aaaatcactt ctttctttgt tatctgtgat accaaaagaa aagtatgatg tcacagtatt
      781 gatgttggag aagcgagggg gatttttaaa acaattacca agttgggtaa agatagaaga
      841 agttacttgg tttgaaaata taaaacctaa aattatgcaa ccaccaaaga aaacgattaa
      901 tgagtatttc gaaaatacaa gatatattaa gggtttaaac tttttactca cttatgtggt
      961 atcaaaaaaa ttaaaggata gatatatttt ctataaagag atttttaaag acattccata
     1021 caataagaat aaatatgata ttgcaatagc atatcaagga cctactgaca taattgatta
     1081 ttatatagtt aatagagtag cttcagaaaa gaaaatttct tggatacatt tcgatgtttt
     1141 tcaacatcaa attaatacaa aattatatga gaaattatat gatcagttgg ataatatata
     1201 tgtagtttct aaagaagcac aaaaacattt aatagagaaa tttcctaaag tagaaagtaa
     1261 gacaagtgtc tttttaaata ttgtacttcc agatttaata aatgaaatgg cgaaagaaaa
     1321 agtagagttt gataatggat ataaaggtat aaagatagta acagtaggta gactttcaaa
     1381 agaaaaaggt caagaccttg caattaaagt tttatcaatg ctacgtaagg agggatacga
     1441 agtacgatgg tactgtatcg gagaagggga ggatagagag tattatgaga cattaatatg
     1501 taagtataat ttgaaacagg attttctatt attaggatca gcaataaatc cgtatccata
     1561 tgtaaatcaa tcagatatat atgttcaaac ctctaggcat gaagggtatt gcctcacgtt
     1621 agctgaggcg aaatgtttaa aaaaacctat tgtaacgact aattttacag gagcatatga
     1681 gcaaataaaa gatggatata atggttttgt tgctgaatgt aatgaggaaa gcctatatta
     1741 caagattaaa tatcttttgg atcaacaaag agtgcgtgaa gagataacga ctaatttgtt
     1801 agaagaggaa tttaacaact tagaaaaggt aaatcgtttt ctaagttaat tgtaaatgaa
     1861 agggtgcaat tatgaatcct aaaattagta ttattgttcc catttataag gttgagcaat
     1921 atattcataa atgtattgat tctatattaa agcaaacgtt caaagagttt gagttgatac
     1981 ttgttgatga tggatctcct gatagttgtg gtgagatttg tgaagggtat gcgactcagg
     2041 atagccgaat taaagtaatc cataaggaga atagtgggtt atcttctgca agaaatgctg
     2101 gattggaaat agcgcaggga gattatatag gatttgttga tagtgatgat tggatagaag
     2161 tggatatgta tgaattgtta tatggtatgt gtgtagaaca ggattgtgat atagctattt
     2221 gtagcagtga aattcattac aatgataaaa ctgtaatttc aagcaatcat ccttttgtta
     2281 ttcatgatag atatagcgcg atgaaagcga tgctagaagg gaatttgtat gatgaagttg
     2341 tttggactaa acttttcaaa agacagttat tagaggatat taaatttcca gtaggtatgt
     2401 catatgaaga tacagcattt acgtataaag ttattcataa gtgtaacaaa gtatgtttca
     2461 taggagaacc taaatatcat tatataaagc gtgataatag tatgatggac caggctgtaa
     2521 aagagattaa aattgattca gtcttaattt atgatgaaat gtgtaaattt atggagcgat
     2581 attataagga gttatataac ttagttatat taaaactagg aaattgttcg atggtagtat
     2641 taaatttaat atcattgagt ggaagactta atgagcataa gagtaaatat tataaggtta
     2701 ttggtatatt gaatcgttat ttttataaaa caatgcgttt aaaagagtat ggaaaaagtg
     2761 taaagttttt attattggca acaaagctac atccattatt gtataaattt ttaattaata
     2821 attttgcaaa aaggggatga agatcatcca gaataatata atttgaatat tcacctctcg
     2881 atggtttagt ttaacttatg aaggggataa atcatgcgaa cgatgcattc aattaagaat
     2941 atatcaataa gtatattttc tcaaatagtt attgttattc taggctttat atctaggaaa
     3001 gtttttttgg atagtttagg aatagagtat ttagggatag atggcttgtt aattaatgtt
     3061 ttatctatgt tagtgctaat tgaggctggt ataggagcga gtatagtata caatttgtat
     3121 aaaccattgg cagaaaataa tcagtataaa attatagcac ttgttcaatt atataaaaaa
     3181 atttatcaga ttttagcaat cattattcta gtaataagtg ctatgatata tcccttttta
     3241 agttatttaa tgaaagaggg ggcatctata tcgaatgttg cgataatcta ttcgatattc
     3301 gtggtaaaga atgtagttac ctatttaaat gctcataaga ggtctttaat acaagcagat
     3361 caaagaggat acatattggc taggatggat ctcttatttc aagtgctaac tacaatattc
     3421 aaaatattta tattaattta cacaaaagat tatatattgt atttaattat agagttgagt
     3481 atatatgtaa ttcaaaatgt cgtaaacggt aggattgtta ataagaacta tccttatata
     3541 aagacaaaaa agaaatattc tatagataat gatacgaaag aaaaattaat tataaatgta
     3601 aaggcgatgt ttttgcataa tattggagga tatattgtat ttggaacgga taatatactg
     3661 atttcatctt ttgtaggcct tgctatggtt gggatatatt cgaactatac aatgataata
     3721 aatcaattag cagctgtagt aaatcctata ttaaatggaa ttgaagcaag tgtaggaaat
     3781 ctaattgcaa ctgagaataa tgacaaaaat tatgcaatat ttaaagtgac ttatttagtg
     3841 aatttttgga tcttttcttt ttgtaccata tttttattta atctgttaga gccatttata
     3901 gggtggtggc ttgataagaa gtatttatta aataacatag tttttgtagt gatactcatt
     3961 aacttttatt taacagggat gcgaaccgcg atagctattt ttaaaaataa agcgggatta
     4021 tttgtacaag ataagtatat tccattagtt gaagcgataa tcaatttaag tttatctatt
     4081 ctattagcta acatgtttgg gttggtaggt atattcatag gaacggcgat tagtacaatt
     4141 gctactgtac tttggattca gccttatatt gtatatagaa atctttttaa gaaatcggtt
     4201 tggaagtatt ttacaacata tgtattttat gtgtttttaa ctgtcgtaac aggtttcatt
     4261 actacaagta tatgtaatta ttttatagaa ggtagtacct ttatttcgtt agtcgaaaaa
     4321 ggtttgattt gcttattagt accaaatgta atatacgttt taatttttta taaaagcaca
     4381 gaatttcaat atataaggaa tatctttagt atgatgtttt tacaaattaa aaagaaacga
     4441 aacgttattt agatataaaa agtatggaca ttatattggt ttgaattatt aaggaagtat
     4501 attgttgttg aagcctgtta gtatgaaatg aaacttgatt ttaattagaa aacgtgaatc
     4561 attagcccta acatagtatt tatataatgc atagtattct attaaaggga tacgtatgta
     4621 agcataatat aaaatatttg tccccatgca ccgatagaag tttgaatttt ctgttaaaat
     4681 tcaatttcta tcttagttgg aggttatata taaatcatgg caaaatttca agtgacatgt
     4741 gttttgaaag ggaatctgcc tgtgttaagc gagggagaat tttgtttttg tatagatact
     4801 tgtgagttat ttattgggac gaaaaaaggg aatgtaaaag tatcaacgga gaataaattt
     4861 gagaggttag taagtaaact taaaagcaat acatttggaa gttctaagtc tagaaaatca
     4921 ctgattgaag aaacagaatc tgctaatgtg gtttcgggca cgtattttct tgagttagag
     4981 agatggaatg ttaaaaatga tggaacggac gcggagaata cttctaaagg gattaataat
     5041 gcattatcat gggcatctca acaaggattt atagaagttg ttttacccat ggggacatat
     5101 ttaattgatg aaaatacacc aattgagcca caaagcttta tgactttaaa tttaggtgga
     5161 tcaactttaa aaataagaag taatggatta tttaaatatg caatcgtacg atatcaaaga
     5221 aatcaaaaat tttctcggat tacgaatgga agggttgaag gggataaaga tacacacgat
     5281 tatacaacga ttccacatac tcatgaatgg ggatatggga ttgaagtagg aaatacgact
     5341 cctgctgagg ggagtaatat gaattatatt tcaatagata atatggaaat tttaaattgt
     5401 actggcgatg ggatagcaat ggaaagtaca tggggacaaa ttggagaata tgattttgct
     5461 ggtacatttg aagtgggggg gattagtgat gtcgatggtt ccctaatagt agatgataat
     5521 aaaattagat cgaatttaaa aatagattta catcatagta gcattataaa atggggatat
     5581 tttggtttgt atggagatgg ctatggtgga actggttcag aaatatacac agaattatat
     5641 gatgtgttat tttatagggc tgataatact tttgtaacgg ctgtgaagag agtaaagttt
     5701 tttgaagaag tgagtgttcc aaaagaagca gattatgcga aaatagttct taaccaaggt
     5761 gaaataccta aggaaaacgg ttgtaaaata actgttagaa ttccggaatt ttcccgaaat
     5821 gtatttattg agaaatgtaa aatacatgat tgtagaaggc ttggggtaag tgtatctgga
     5881 gcgaaacaaa tctatattag agattgtgaa atttacaaaa tgaaaggtac agcacctcag
     5941 ggagcaatag atattgaaga tggatatcga ttaaatcaat atataaacat tgagcgtaat
     6001 aacatatatg ataatcaggg atataacgtt gttgtagtcg gtggtagata tattaatatc
     6061 attcaaaata aattagctaa taattcatta gtagtaggcg aaaatgtaga gaaagtgatt
     6121 ataaacaata atcacttaag ggaagtaagt tgtgttttaa gcggagaagt aacttttacg
     6181 aataatcaaa tgtatgctac tcgagtcacg atagatcaag gagataagga agcgcttatt
     6241 ggtaactgta ttttccataa tagcgcattg ttaatgggaa gagataaagc atattgtatt
     6301 caagtgaatc aatgtgaatt ttttagtgat cgagatttat ttcattcttt ttcacagttg
     6361 ggttcaataa ttggtttttc agcagaaccg caaactatat caaattgtgt tattaaaggg
     6421 ggggctgtag agggtacaag tttgacaggc gtatcacctg gtatgaaaaa tggatggaga
     6481 ttaaataata tttcttttat agatacgaaa cacccgcaag gaatcattac gaatttaccg
     6541 ccaggagtat atacgggatg taaatttgag aacagcggta caatatcatt tgttacaaaa
     6601 actcctcaag cagaatatga atttaatgga tgttcattta gttgggatgc ctataatctt
     6661 tttactgttg agtcttctca aaggatatcg atgctaaaag tgaaaaatag taattttaga
     6721 gggggaagat ggggctcagc atttttttta tgggacattg ggggaagaat agaatttagt
     6781 aataatgcat ttgaatacct taattcggaa tcgacagaca gtataattaa tttttggaat
     6841 gaaacattta cgagtgagtt tatgttaata gaaagtaata tatttaggtc aaataaaaac
     6901 atgataggct tgaatgcaaa tcagatttca tcctcaatca ctttgatttt taaagataat
     6961 attgtggaca cagtagttat aaagttaagg gatgaacata taaaaaagga taattatatt
     7021 aatggcgtct ttgatccgta catgtaaagt tatagaaact aatggagtaa caggtccttt
     7081 gtaaataagt agtgataccg tatggaaata ttcacatagg ctagctatgt ttaaactatt
     7141 tgatgagata aaattaatga aagatgacgt aattaaacaa aacaaggggt aactaactgt
     7201 agttgcccct tgttttgttt aattgcatat aaatttctaa atggtccttc gtgttaggag
     7261 tattaaacgt aaataagtaa ggaggatagt acatgaaaag aatttttgat gtatgtattt
     7321 ctttattgtt attatttgta tgtttgcttc ctattcttgt tgtagcaatt ttagttagga
     7381 tgaaattagg atcacctgta ctgtttaaac aacagcgtcc aggactgcat ggaaaaccgt
     7441 ttaatgttta taagtttaga actatgctag ataagaagga tagcgatggt gaattacttc
     7501 cagataaaaa tagactgact acttttggag aaattcttag aaaatatagt ttagatgagt
     7561 taccccaact tataaatgtt gtaaggggtg atttaagttt agtaggtcca cgaccattat
     7621 tgatggaata cttaccccta tattctagta aacaggctaa aaggcataat gtaaaaccgg
     7681 gaattacggg atgggcacaa ataaatggta ggaatttgat tacctgggaa gaaaaatttg
     7741 aattggatgt atggtatgtg gagaatcgct cttttttatt agacttgaaa ataattgttc
     7801 ttacaatatt aaaagtattt aaaacagagg gaataaacca tatagggcat gtgacaatgg
     7861 agcgatttac tggagggaaa atagaaataa agggggaggg aaaatgaaaa ttttaataat
     7921 aggatgtggt gggcatagca aggttgtgag ggatataatt ttatcaaata aaggatatga
     7981 aatagtcggt tatttagatg atttgtatac aggtataaat attgtagata atctttattt
     8041 tggagcaatt gcagatgcaa gggaaattat caataatttt aatgatgtaa agctcgttat
     8101 tgctatagga aataataaaa ttagaaggga aattgcagaa atattaaatc aacaaagtag
     8161 catatatgct actttaattc ataaaacagc cattataagt tcaaatgctt atataggaaa
     8221 cggaacggta attatgccaa atgtggttgt taatgcggat actttcatcg gtaaccatac
     8281 tataataaat acgggctcaa taatagaaca tgataatata attgatgatt ttgttcatat
     8341 ttcaccacat gctacgctta caggttctgt cactatagca gagggggcac atataggagc
     8401 atcagctact ataattccag gtgttcaaat tggtaagtgg tcaattgttg gagctggttc
     8461 tgttgtcata aatgattttc catctaattg tactgctgct ggtattccag ccaaagttat
     8521 taatgtagta aattgagagg agatgaagaa tgatgataaa aaataaggag aaaatctatc
     8581 tttcctctcc acacatgagt ggaaatgaac aaaaatatat taaagatgcc tttgactcaa
     8641 attggattgc acctcttggt ccaaatgtag atgaatttga aagagagctt gcttcttttg
     8701 taggagttaa aggtggggct gcggttagtt cgggtactgc tgccattcat ttagctttgc
     8761 gattattaga cgttcaaaag ggagatacag tattttgttc aagtttcact tttgtagcga
     8821 gtgcgaatcc gattgtttat ttgggagctg aaccggtatt tattgactca gaaccggaaa
     8881 catggaatat gtcaccacaa gctctagcat ttgcgttgca tgatgctaat aaagcaggga
     8941 aattaccgaa ggctgtcatt cttgttcatt tatatggtca gagtgctaag gtagatgaaa
     9001 ttctttcgct ttgtaatcaa tatgatgttc ctataatcga ggatgcagca gaatctttag
     9061 gttctacata taaaggaaaa gctagtggta cattcgggag gtttgggatt tattcattta
     9121 atggaaataa aattattaca acttcgggcg gtggaatgct tgtttctgat gatgtggaag
     9181 aattagaaag agcgagattt ttagcgacac aagcaaaaga tccagcacca cattatgagc
     9241 atagtgaagt aggatataat tatcgaatga gtaatatact agctggtatt ggaagaggac
     9301 aattagaagt gttagaagac agggtgaaag ctagaagatc tatatataaa cggtattacg
     9361 aagcgctatc tttcatacca ggattttatt ttatgcctga attagaaaat actcgttcaa
     9421 atcgttggct cactacattg acaattgatg aaaaggaatc cgggatctct attggaaaag
     9481 tgttgagaat tttagcagaa gagaatattg aggcacgtcc tacgtggaag ccacttcata
     9541 tacagtcgct ctttaaaagg aagaagtact atccgcacag caaaaatgaa gatgtgtcgc
     9601 agcacctatt tcaaagtggt gtttgtttgc cttcaggatc taatatgtta gttgaagatc
     9661 aacaaagggt cattcaaggc gttttaaagg ctctagaagg aaagaaataa aaagtaagta
     9721 aaagtggaat ttgatttgta aatgtacgaa taaaagttct ttataatgaa tttttttgtg
     9781 agaaatattt gcgaatactc agtttaaatt gacataaaaa ggatatggtg ctaggtttta
     9841 aatatcaaaa tcttaatcta caagcgaatt aaagtaaata attgagacgg taataaaata
     9901 agtggttttg ttctttaaaa agaatgataa agaggcatgt ttaacgaatt taatatataa
     9961 atagtatttg tattaacttt tcatatatta ggagggaaaa atgagcgcta taactggcat
    10021 tattcacttt aataacgaac ttgtatcaat tgaacatggc acacgattaa tgggtgactt
    10081 acaaaagtac cctgctgatg atattcaaat atggcgtaaa gaaaacgctt ttctgggatg
    10141 tcacgcacaa tggattacac cagagtcagt tggtgaacaa ttacccttct ataattatga
    10201 aaaacaactg gtaattacag cagatgctat tattgataac cgtgatgagt tgtttgaaaa
    10261 attacaagta gattatgcgg atagaaaaaa tatgacagat agtgagttga ttttgctctc
    10321 ttatgagaaa tggggagaag cagcaccgaa atatttggtg ggcgattttg cctttatgat
    10381 ttgggatgag aaaaaacaaa ttctgttcgg agctagagat ttttctggga gccgaacact
    10441 ttatttttat cgtagtgaga ataaatttgc tttttgtact atcataaagc cgttatttac
    10501 tctaccatat gttgaaaaaa cattgaatga gcagtggatt gctgaatttt tagctatacc
    10561 tgtaaatttc gagtcagtag atccacagct aacagtctat aaatatatag aacaggtccc
    10621 tccatcacac actgttttgg taaaggatgg aaaagtcgaa ttttcgcgat actatatacc
    10681 aactgctggg aaaatgctta atttaaaatc aaatgaagag tatgaagagg cgtttcgaga
    10741 ggtgtatcaa agtgcagtga aggcacgttt acgaacacat cacgaagtag gagctcattt
    10801 gagtggaggg ctagactcag ggtctgttgt tagctttgct gcaaaagatt tacgcgctga
    10861 aaataaaaaa ttacatacgt ttagttatgt tccagtagaa ggttttgaag attggacaca
    10921 taaaggtagg atagctgatg aaagaccttt tattcaatca actgtagggc atgtagggaa
    10981 tatacaggat tattatttag cattgccgga gagaagccca ctatcggaaa ttgatgattg
    11041 gctggaaaca atggagatgc catataaatt ttttgagaat actttttggt tgagtggagt
    11101 ttatgaaaaa gcatctcaac atgaaatagg agtactcctt agcggccaaa gaggtaattg
    11161 gacagtatcg tgggggccaa tgttagatta ccaagcaatg ctgttaaaaa agttacattg
    11221 gattcgtttt tatcgtgaac tacatttata tagtagaaat ctaggagtga aaaaagcacg
    11281 tgtttttgaa gtggtaagaa gaaaggcttt tccgtatttg tttcagttac tttcttcaga
    11341 ggaacaagat gtttttccta taataatcaa tccggaattt gcaaaaaaaa tgaatgtttt
    11401 tgataggctc aaagaacagg atgttgatat aacaggtacc tctagcgcaa ctgcatatga
    11461 catgaaaaga gaacaatttg aaaaaccata ttattggagc ataaatggaa cgtatgaaac
    11521 gaaattatcg ctacgttatg ctttatggga tcgtgatcct acaaatgact tacggattat
    11581 tcaattttgt ttgtcagtcc cagaagaaca gtatgttcaa aatggtttag atcgatctct
    11641 tattcgcaga gccacaaaaa atttccttcc ggataaagta cgattaaatc aacgcgttcg
    11701 aggtgttcaa ggtgcagatg gtgtttaccg tatgactcca ttttggaacg aattcattga
    11761 ggaagttcaa gaacttagtg tagatccaat aatctctgaa tttctaaatg tagaggtaat
    11821 taagaaagct atctcaaaaa tatgtaaaga acctcgacca gaatatgcat ttgatttaga
    11881 ttttagaatt ttaatgcgta gcttaatctt ctatcgattt ataaaaaaat ttaatatgaa
    11941 aggaggtgat acgtatgaaa aaggaatgga aacaacctgt attagaagta cttaatatta
    12001 atatgactat ggctgggcca ggacataaaa ttcctgacgc agttcaacct gatccagatg
    12061 atccagtgaa gtatagttga gtcattggaa aaataaagct cttatatagt tttattatat
    12121 aagagctttc aaaaaaattg acaatgtggg gtgaatagga tgatcgattc gaggggaaat
    12181 gtgttataca aagccttcgg gttaaagata gtaagtgaaa ttccattacc tgaattgtct
    12241 cagctgaatg aaaagaaaga gatggcagat attcaaatag aaatgactga tttatctgaa
    12301 cgatggagtg gatataacga agaacagcaa agaacaattg tagtggaaga tgatgtagtt
    12361 atgtttcatg ttcctcaaac tgcaatattt tctgtccaag cgggtgagaa aattactttt
    12421 tcacctatgc cagaggcgaa agaagataaa attcgattat acattctggg aacttgtatg
    12481 ggggcacttt taatgcagcg aaaattactt ccattgcatg gaagtgtaat tgccatagat
    12541 gggaaagcgt atgcattaat tggtgattca ggagctggaa aatcaacgtt agcctcggct
    12601 tttttgaatg caggatatca gcttttaagt gatgatgtag ttgctgtatc tcttttggat
    12661 aaaaatacta cagtagttca tccttcttac gcacaacaaa aattatggca agagagcata
    12721 aatgagttag gaatggaagt agcgcaattt agccctttgt ttgaaagaga aacgaagtat
    12781 gctgttcctg tgaattctca atttttcccc gatccattac ctcttgctgg tgttattgaa
    12841 ttagtaaaaa cacagggaga agatattgaa atgatccgta tagaaggtct cacacgcttg
    12901 tacaagttat accaacatac ttttaggaat tctttgattt ctaaattggg attgatggaa
    12961 tggcattttg aaacttcatc taatattgca agtggaatgg aaatgtttca attaagacgc
    13021 ccggattcga aatttacagc tcatgagctt gtgcaagtta ttttaaatac tatacagaaa
    13081 gggagtatgg ttgatggttg ttcattcgag aaacatatca ttagaacata atgttgtaca
    13141 gagtgaaggt aatatagtaa gtgatatgga tggagaaaaa gttatgttaa atgtccaaaa
    13201 aggaaattat tataacttag gtgaaatagg cggagaaata tgggagcgta ttgaaaagcc
    13261 gataaaaatt aatcagcttg ttactatgtt agtatctaac tatgatattg aacgaaaaga
    13321 ttgtgaagag caagttcttt cctttttaga gtgtttattt caagaaggct taattcaaat
    13381 agaagatcaa tctaatagat aaattcgtaa tttcaagaga actgttagga agggattaat
    13441 gaatattgtg aaaaggttaa gggcattttt atcgctgaac atggaaacaa agcttttatt
    13501 tttagaggct tttatttttt tagggtgggc gcgtgtacta aaaagtatta ccttttccaa
    13561 agttgcacct tctttagggg attacatgaa cgaaacatca gttgcccaaa ttcagccaca
    13621 cggggataca ctaaagaagg tatctgaagc tatttctatt atgagtcgtt atactttttg
    13681 ggaaagtcag tgtcttgtta aagctatagc tgggatgaaa atgctcgaaa aacgtcacat
    13741 tgagagtact ctttatttag gaactgctaa ggatagtcat ggggaattaa ttgcgcatgc
    13801 atggttacgg agcggttctt tttatgttac tggatcagaa ggaatggaga aatttactgt
    13861 cgttggatca tttgcaaaga ggctaagtga ggacattatt aaaggagaat aaaatggaga
    13921 aagattttgg tctggatgta gagttcatgt ctaaggaatt gaaacttctt tttgcaattt
    13981 tgaagttaca agatgatgaa acagtacaaa cttacagtaa tgaatggttt tcggatattg
    14041 attgggaggt gtttcttgag caagctgtgc atcatcgcat ttatccggtg atatatcaaa
    14101 aacttaaaca ggtggatgag gaactaattc cttcacatat tgtacaaacc ttgaatagaa
    14161 aatataaaaa aaatacattt cacatgcttt atttaagcgc tgaaatggaa cgaataaata
    14221 aactatgtaa tgaaaatgaa attcgtatga tttttctaaa aggacctgta ctatctcagg
    14281 acttatatgg ggatatttct ttacgaacat cctgtgattt ggacgttcta attccgatgc
    14341 gaaatttaga aaaagtagaa atgctacttt tagagcaggg gtatgtaaaa gatgattata
    14401 ttcaaacgat attaaatgat tggaaatgga ggcatcatca tataacattt tttcatccaa
    14461 caaagcagat taagcttgag attcattgga ggttaaatcc cggacctggt aaggaacctg
    14521 ggtttgaaga actttggaag cgaaagagaa aaagtacact tacaagtaat tcggtatata
    14581 tgttaggaaa ggaagactta tttttatttc ttgtatctca tggtgctaga catggttggt
    14641 ccaggttacg ttggttagta gacataaaaa aaattgtcgg tcaagatctt aactggaatg
    14701 agattcataa attaatgaga aaatatcaag tgcttcattt aggaggacaa gcattaattt
    14761 tggcatcaca attgctaggt gtacggctag atgaaaggat gacggaatta gtagctaaaa
    14821 aacagtcgaa gcagttagcg caagaagcac tgttttattt caagaaaatg ataaatttac
    14881 attcagaacc tgttcctgaa gaagtacgtt cctatcatag tagacattta ttttcactga
    14941 tgtctaatca gcaaaaaatt atatttattt tgagccaact ttatccttat ccaattgatg
    15001 aaaaaacctt accgttacct aaatttcttc attttttata ttttccttta cgtccgtttt
    15061 tatgcctttg gaggaaaaca aagaagcttg ctttgttata gggggaacat cgatgaatca
    15121 tattatatat tttatgaaga aattatattc ttcagcggga aaaatactgt atgtgaattt
    15181 atttggtatg gttttaataa gtttacttga agggataggt attgttttat taattcctat
    15241 gataagtatg actggaataa ttaatataga cgaggagact acttttattg cacctgtctc
    15301 tagatttttg caggatttcc ccaaaacaac aagtctagcc tctattttag gtatatatat
    15361 actaatagtg ttaggtcaaa atttactaca aagaaatata acgctaaggg atgcgagaac
    15421 gcaacaagct tttgtacgag agttaagaat agaaacatat agtatgattt taaaagcaaa
    15481 gtggagtttt tttttagaga aaaggaaaac aaacctaata aatatattaa ctacagaatt
    15541 agctcgtgta agttatgggg ttaatttaat tttacaattg ttagctgcta ttctgtttac
    15601 atttatacag gtggggattg cgtttttact atctcctcaa ataactatat ttgttttggt
    15661 ctttggctta ttattcttgg tagcttctcg tgtttttata aaaaaagcac gaatactagg
    15721 cggtaaaacc tcagaattgg caaaaaacta tctttctggt ataacagatc attttaatgg
    15781 aattaaagat ataaagagta atactttgga atcatcacgt atagattggt tacaatctat
    15841 aacagaaaag atgagcaatg agcaaatgga gtatatgaga ataagatcga gctctcaatt
    15901 gttttataaa gtttcaatgg ctatattaat tgcatgtttt ttattattat cagtaagtat
    15961 gtttcaagcg caatccaccc aattactatt aatcatcctc attttttcta gactatggcc
    16021 gagattcatg acaattcaat caaatttaga acaactagct gcaagtattc cggcttttaa
    16081 gtcattatgg gagctgcaag aggaatgtaa ggaagcgatt gaaatgcagg atatacatca
    16141 gcaaaagtat ataaagccga tttgtattga gcaaggtatt gagtgtaagg atgttcactt
    16201 tcgttataat aagcaagaat ctttatacgc acttcaaaat attaatgtgc aaattccaat
    16261 aaatagtatg acggccattg tggggcattc tggtgcagga aaaagtacat taattgatgt
    16321 attaatggga ttaatccagc cagaaaaagg tcaagtgtta atagatggta cgccacttac
    16381 aacagataat ttattgtcat taagacgggc tattagttat gtaccacaag atcctttctt
    16441 atttaatgcg agcataagga ataatttatt gatgattgaa ccgaatgcaa gtgaggaaga
    16501 aatttgggat gcattaagtt ttgcggccgc cgctgaattt gtacaaacgc ttcctaatgg
    16561 gcttgataca ctgattggag atcgtggggt gagactttca ggtggtgaac gtcagcgact
    16621 tgtattagct cgggctattt taagaaagcc atcgatttta gtattagatg aagctacgag
    16681 tgcgttagat actgaaaatg aagtgaagat ccaatcagca atagaaagat tgaaaggaac
    16741 aatgactatt gttgtgattg cacatcgttt atcaactata cgtaatgcag atcaagttat
    16801 cgtcttagga aaaggtgaaa ttgtccaaaa aggtgaattt aatcaattgg ctaaagagag
    16861 aaaaggtgta ttccgaagtt tattaggggc acaaatggaa gttggttctt agaagggaaa
    16921 gagtgaatga atttttgtat tcatacagtt cgaatcgaat aaaagcctga gtgatggcca
    16981 gttataacag gacattattc aggcttttat ttgtacgttt tctacatttt gggagtaaat
    17041 ataaatgagt accttgcaat gaataatact aagtggtata ttatggatat aataggtacc
    17101 gtgtattgaa cagtactgaa atgagaaagg gggattgacc ttgaacgttc agtttaaaaa
    17161 aggtgtgtta gaactgtgtg ttttagcact tgtgaaacgt aaagattgtt acggttatga
    17221 acttgtacag caaatctcaa ataaattttt aatatcggaa gggtcagtgt atcctttatt
    17281 acgtcgttta acgaaagaag gatattttca aacgtattta aaagaatcta cagagggacc
    17341 gcctcgtaaa tattatcaac taactgagca aggggaaacg caactaaagt tgttagtaac
    17401 ggagtggcgt gattttgcaa aaggcgtaca agaaattatt gaaggggtgg agtgggatga
    17461 gtaaagaaca gtttcttaaa gaattatcaa gtcatcttag aaagttaccg gaagaagaga
    17521 ggaaagatat tttatttgat tatgaagagc attttcagtt tggaatagaa gaaggaaaaa
    17581 ctgaatcgga aataataaag ggtcttggct ctccgaaagt aattgcgaaa gacttacttg
    17641 ctttgtatcg ctttgatgaa atgaaaaagg acccatctac tactaatata acaagggctg
    17701 ttatggcagc gattggactt agtttgttta attttattat tgtgttaggc ccgttagttg
    17761 caattattgc ttttatattt tccttctggc tcggtggaat tgctagtgta gtgacaccat
    17821 ttttcgttat tggaaaagta tttatgggta cttttatatg gttggattta ttcgttagta
    17881 taacgtttgt tggggtaggt ttgttgttat gtattatcgc ttattatagt acgaagtggt
    17941 ttaaaaagtt atgcgtacgt tatgtaatat ggaacttcaa aatgataaaa ggagagtaga
    18001 tgatgaagaa aatattgtta gtagctatcg cttgtatcat tattggagta atagggattt
    18061 cacaaacata tgaaaaagca gtgcaaactg cagaagaagg aaataaagaa gacgtaatta
    18121 aaaacgaaac actaaaaaat atagaagtta agttagatgc tggggatatt gttgtccaaa
    18181 aatctcccga ctcttctttt tatgtaaagc aatcaggaga tgtacgtaaa cacgaggttc
    18241 gtattgccga agatggtgac acattaaaaa ttattgggga aagagaaaaa ggtgcttcat
    18301 ttgatttttc tttttacgat tttagatttc aaacgtctac aataactctc ctcgtgcctg
    18361 aacgttcata ccaagagata aaaataaatt catcagctgg acaaatagaa ataagtgatg
    18421 tgaaaagtga ttgtgtaagt gttgggacac tcgctggaga agtagatttg aaaaatgtca
    18481 cagcaagaag tgtggaagga tcttcaaaag ctagtgaggt gagctttaag aaggtaatag
    18541 gaaaagtaac tgcgaagtcg gctagcgggg aagtgcatat tatggatcat gatcctaaat
    18601 ctaaatatga tgtagaggca agttcaactg ctggggatgt agatattact ttattagaaa
    18661 aaccacaaga tgcagttata actgggcaaa gtgctgctgg tgaagtaatg atttttaatg
    18721 aagaaaataa aaatataaca attggcaatg gtagtaaaaa gattagtggt aaaacagctg
    18781 ctggcgatgt gacgattgaa actcgttcat aagaaataaa atgtatgaaa atctatcaaa
    18841 atacaaaaaa agaagataat taccgtatat aaataaggta attatcttct ttttttattc
    18901 ttaatgtaaa tcacgatata cgccaattac ttttccaata actgatactt gttttaaaat
    18961 gataggttct aatgaagagt tttccggttg tagacggaaa tggtcttttt ctttatagaa
    19021 acgtttaaca gttgcttcgt tatcttctgt taaagcgact acaatttcac cgttgtatgc
    19081 agactgttgt tggcgaacaa caactaaatc cccatcgaaa ataccagctt caatcatact
    19141 atctccggaa atacgtaaca taaatacttg gtctgctcca gcaacaatgc tagctggaag
    19201 tgggaagtga tcttctacac tttcaattgc tgtaattggt aatccagcag taacttttcc
    19261 gacaattgga acttgaataa cagattgtgt ctctgtatcc attcggttgt cacctaaaat
    19321 ttcaattgct cgtggttttg ttggatcgcg tcgaatatat cctttttctt ctagtcgtga
    19381 taaatgtccg tgcactgtag aactagaagc gaggccgact gcttgaccga tttcacgtac
    19441 ggaaggtgga tatccttttt cttgtacttt tagcttaata aagtcgagaa tgtcttgctg
    19501 gcgtttcgtt aacttttcca tgttttctaa cacctcgttt tctttcattt ttcttattaa
    19561 taagtataac atgcgaaaaa acattctaca aacataagtt cgaacgaaag acgaatttat
    19621 gatacactat aaggaaaata tagtgagaaa gaagggttca aaatgaatgc aattatttat
    19681 gcgcgtgtga gcacaacaaa agaagaacag gaaacatcat tattgcgtca aaaagatgaa
    19741 ttattgcatt tagctgagcg ctatcaaatg aatgttgtaa aggtgattga ggagcaggct
    19801 agtggttata caattgaacg tgatggcata ttagaagtgc tagatacaat tcgcgatgaa
    19861 caagttgatg tacttctcat acaagatgaa acgcgccttg gtagagggaa tgcaaagatt
    19921 gcattaatgc actgtttaca taaagaggga ataaaagtat atacgcatac gcataatgga
    19981 gaattagaac tctctgactc tgattcgatg gtactagata taattgggat tgttgaagag
    20041 tatcaaagaa agatccacaa tttaaaaatt aaacgtggca tgcaaagagc ggtagagaaa
    20101 ggatttcgtc cagagaataa tttgaaaaat cgtcatttaa gtataggacg tgagaaaaaa
    20161 gaagtgccaa ttgaggaaat tgtacgttta cgccggaatg aattaacttt tgaagaaatt
    20221 gcagcaacac ttcgtggttt tggtcatgat gtttcaaaag caactgtaca tcgaagatat
    20281 gtagaatata caaagcaatt gcttgataaa gaggactaac tattgtatga taataatcag
    20341 ttttgagtaa aagggggatt cgagatgcaa agtcacgaac tcattgaacg cattaacttc
    20401 ttagcgaaaa aagcaaaagc tgaaggttta actgaagaag aacaacgtga gcgccaatcg
    20461 ctacgtgaac aatatttaaa aggatttcgt caaaatatgt taaacgaact taaaggaatt
    20521 aaagttgtta acgaagaagg tactgatgtt acaccggcga aattaaaagc tttaaaaaag
    20581 caagataatg caaaattaaa ctaaaagatg ggcgaagccc atctttttta tttattatat
    20641 ccgttattta ataactttcc agttgttatt gactgttgct tctatatttt tgtgcttcaa
    20701 tatatagtta gcgataagtt cagacatatc tgttggtatg tcttttatta cgggcttatt
    20761 ttgaaacata aagaagttcc ctccgccact tgcgcgataa ttattcataa cgacgtcata
    20821 ttcttcattc atatgaagtg gagcgccttt atactgtaag gattctactc tctcgccaat
    20881 tggtttggaa atgtttaata cgtacgaaat tccttcccac atatcgtaat tatagtgttg
    20941 cggctttggt tctatgtagg tagggtttac gatgatagtt ccatctgctt ttaatatgaa
    21001 ataagaagca gagagttcaa gggcatcttt tatatccgct ccagttattc taattacttt
    21061 taatgtattt ggataaatat aattagaaac gatgtcacgc attgttacgc gattagggaa
    21121 acctggagat gtattatgga ataagcttgt acaagaaatg gaaacattag ctatatccat
    21181 ctgtatttta tttatgaatt caataaaagg atggtcttgc aaacgagttt gcatagcatc
    21241 tgaaatttgc atgtccccat agattactcc aataggttga tcgagccaat tttgtgtttt
    21301 ttcttcataa tcggcaacca aggaaagaat atcttggtca gcctcaattc cttgtacggg
    21361 caataattgt gaataactct ctttttttac ccattttttt tctgtttttt cgaatgttac
    21421 tgttactttt ccaacggagt gtccattgca tccaatctgt aaaattgtta caccattcat
    21481 tacggtgtga gcgatttccc ggtgttggtg gcctgttagt aaaatgtcta taccttcaat
    21541 ttcatggcac attgcatatc cttggttttc acctgttaaa acttcagtcg gtaccccagt
    21601 ttgtaaatcg cgttcaaatc ccccatggta ggctacgact aataaatcgg gtttctcgtg
    21661 ttcgcgaatg taagaaaccc atctttttgt tgtttctaat gcatcttcaa attgtaaatc
    21721 ttgaatgtga tggggttgtt cccaattggg aatgtaatgc gttgtcatcc ctaaaatagc
    21781 aatttttata tttgattcaa tatgttttat tatatatggt ttcccgaaat aaggttcttt
    21841 tctgttttta tctaaaatat ttgctgatag atacggaaag tttgcagtag aaatagcatt
    21901 atttaatatg tccattccat aattaaattc atgattccca ataactgcag catcataacg
    21961 taaatagttc gctaataaag acattggatt tttcttatct tcttcatatg tagcgtaatg
    22021 ataagtgaag ggtgttcctt gtatgaagtc accgttatca attaaaagaa cgtttctatt
    22081 ttgggaacgt tcttttttta taagagtaga aattttggct aaaccaattt cagcttggga
    22141 gttatcttgg tagtgaattg gataaacagt gccatgtata tcacttgtta ataaaatgtt
    22201 taaagttaca atttgatttg gattcaatat cattcacctt ttctattgtt atctactaat
    22261 taagcatatc aaatatatga agagaatttt aatgagaatg tatagaatgt gtaaagattc
    22321 tgtaaataag caattgtgcg tgaaaatgtg tgatatattt cttcatgttt acggaaggca
    22381 attttataac aacaaaattg gaggcattaa tatgttgaaa aaagtttttg caatgagtac
    22441 gacagttgta ctagcggcgg gattattaag tggttgtgga acgaaagaat caagtgcaag
    22501 taaaactgaa gatacgaaaa aaggttatgt accgaagact ttaaatgttc aatttgttcc
    22561 ttctcaaaat gcagatacgt tagaggcaaa ggcaaaacca ttggaaaagt tattaagtga
    22621 taaattaaat attccggtaa aagttagcat ttcaacgaat tacaatacaa ttgtagaagc
    22681 gatggcgtct aagcaagtag atgtaggttt tttacctcca acagcgtatg tgctagcgca
    22741 tgagaaaaag gctgcaaacg taattttaca agcacaacgt tttggagtag atgatgaaac
    22801 gggagctcct acaaaggatt tagtagactt ttataaatct gagtttgtag ttaagaaaga
    22861 ttcaaatatt aacagtgtaa aagatttaaa aggtaaaaaa attggttatc aagatgtaac
    22921 gtcatcagcg gggtatgtat ggcctgcggc tgtattgtta aaagagggaa ttgatccgct
    22981 aaaggatgtg aaacctgtta cattaaaagg tcacgatcag tcgctgattg ctcttttaaa
    23041 tggtgatgta gatgcatctg ttgtattcca agatgctcgt aatattgtga aaaaagatta
    23101 tccgaatata ttcgatcaaa cgaaaatagt gaaatttacg gaaaaaattc caaacgatac
    23161 gatttcggta cgttctgatt tagatgcaga gtggagtaag aaattacagg acgctttcat
    23221 tgaaatagga aagaatgagg aaggtcacaa aatcattaaa gaagtatatt cacatgaagg
    23281 atatgttaaa tctgatgata gtaaatttga tatcgttcgt gaatatggaa agaaagtaaa
    23341 aacgcaataa tacatatgga aatggcagct aactggaagg tatatgtttc cagttagttt
    23401 gccattttga atacatagaa ggtaggtaag atgtgtgata gaatttcgaa atgtttccaa
    23461 aatgtatccg aatggtacaa aaggattgaa taatataaac ttgaacattc aaaaaggtga
    23521 gtttgttgta atggtagggc tgtcgggggc tggaaagtct acacttctta gatcggtaaa
    23581 tcgccttcat gagattacag aaggagaaat cttgattgaa ggtgagtcta ttactgctgc
    23641 gaaaggaaaa gaattacgac gcatgcgccg ggatattggt atgatttttc aaagttttaa
    23701 ccttgtaaaa cgatcaacgg ttttgaagaa tgtattagct gggcgtgttg gataccattc
    23761 gacttttcgt acaacgttag gtctatttcc aaaagaagat ttggagcttg cctttcaatc
    23821 gttaaaaagg gtgaatattt tagaaaaagc atatgcgcga gctgatgaat tatcaggagg
    23881 acaacagcaa cgtgtatcga ttgctagagc gt
//
