LOCUS       NZ_CP022203            10846 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Corallococcus macrosporus DSM 14697 chromosome, complete genome.
ACCESSION   NZ_CP022203
VERSION     NZ_CP022203.1
KEYWORDS    RefSeq.
SOURCE      Corallococcus macrosporus DSM 14697
  ORGANISM  Corallococcus macrosporus DSM 14697
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Myxococcaceae; Corallococcus.
REFERENCE   1  (bases 1 to 8973512)
  AUTHORS   Rupp,O., Goesmann,A. and Sogaard-Andersen,L.
  TITLE     Sequencing and comparative analysis of myxobacterial genomes
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8973512)
  AUTHORS   Bruckskotten,M., Treuner-Lange,A., Rupp,O., Goesmann,A. and
            Sogaard-Andersen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-JUN-2017) Department of Ecophysiology, Max Planck
            Institute for Terrestrial Microbiology, Karl von Frisch Str. 10,
            Marburg, Hessen 35043, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 09-AUG-2016
            Assembly Method                   :: Celera Assembler v. 8.1
            Expected Final Version            :: yes
            Genome Coverage                   :: 83.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002305895.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:36:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,344
            CDSs (total)                      :: 7,262
            Genes (coding)                    :: 7,199
            CDSs (with protein)               :: 7,199
            Genes (RNA)                       :: 82
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 26 of 63
            Pseudo Genes (incomplete)         :: 45 of 63
            Pseudo Genes (internal stop)      :: 2 of 63
            Pseudo Genes (multiple problems)  :: 10 of 63
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:23:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6098519
            Orig. end                         :: 6109365
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022203.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10846
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="22"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10846
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10846
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5846](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5846)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            417..1220
                     /locus_tag="MYMAC_RS24350"
                     /old_locus_tag="MYMAC_004832"
     CDS             417..1220
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013941503.1"
                     /locus_tag="MYMAC_RS24350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_004832"
                     /product="hypothetical protein"
                     /protein_id="WP_204816933.1"
                     /transl_table=11
                     /translation="MRHLDDVALSALSRREPEAVAYFAEHLAHPCDTCEAFLAAHAGPD
                     LLDGQVDALLLGLAPPAASAAPLDEVGLARVRRALRTHPPAARRWGLVAGGLAACVLAL
                     VLLPRMRAEAPGPQTGAPGPWTGEKGRVAHIALELSVAARASDGVLRRLDPGSRVEDSD
                     VLLLRYHATEAGSALLFVQRQGEPPELLGQFPLTAGTHDLRGPQGLAGVSLTGETGPVT
                     LWLVGAEGAPPDTRVVREMLEGQTAPGALAVIRFDVSVRSGQNRP"
     gene            1231..2871
                     /locus_tag="MYMAC_RS24355"
                     /old_locus_tag="MYMAC_004833"
     CDS             1231..2871
                     /GO_function="GO:0004197 - cysteine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011554929.1"
                     /locus_tag="MYMAC_RS24355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_004833"
                     /product="caspase family protein"
                     /protein_id="WP_095959825.1"
                     /transl_table=11
                     /translation="MRRLLPILLACLAACAAPSSGEKGGLVPLTLDEASLSSAYKPRRM
                     ALLVGISSFDDPRWRGLRYTGKDARDLGAALSDPARGHFDHVRVLTRREETTRTAILAA
                     LRQLKQEANRPDDVVVVYFSAHGTLARDAKGELRRYLVTRDASYRNIPQTALGMDALKA
                     EFDGLASRRRMLVLATCHSGSGKSLLPRELKAELEGIKSGFYARPLEESSRASMVFAAC
                     DWGETAREDESLRNDIYTHFLIDGLSGAADRNGDGAVTATEAHDHARRRTFAFTEGRQR
                     PSAEILEVGADPVVLSGSITRSGRPELFSYNPRLDGFTLKVDGEARTELPGGAAVPPGR
                     RTVELTKGDAVLMRRDVEVGQGDRLPLERLLAQAFPRRSLSLLGGMFSFADARSRAELL
                     PVSPEVALSLRLEDKPLEDFGLLFDVAFSTGQRHLRLTPGSEVPFRYTTFAAGAALPYL
                     WRWERLTVFAGPRVAGLYLRRSFDVEAAATGQRFFTVSPGVVGGIVWRVGERLELMSQA
                     QLMLTYVVVDGQGQAVGFTGGWAGAGYRF"
     gene            2871..3992
                     /locus_tag="MYMAC_RS24360"
                     /old_locus_tag="MYMAC_004834"
     CDS             2871..3992
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011554930.1"
                     /locus_tag="MYMAC_RS24360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_004834"
                     /product="carboxypeptidase-like regulatory
                     domain-containing protein"
                     /protein_id="WP_095959826.1"
                     /transl_table=11
                     /translation="MRSTFHIAVATLLTCVAAGCGNLENAPFRVGTVHGQLTESDPAVA
                     MVSLVEQPGVSSHVDADGHFTLRDVPSGPAELFIVATSEKAARVQVQVPGGQSVRVRPV
                     EPTPAGFFDLRVKTTNGFRLPATEVSVEGTPFQRLLLDAQGRLRVGPLPDGCYAVSVTA
                     IGFPRTQTEACAGPGERKELKVDLEVDASLLEQGCQEHGCEEGLVCAPNKKCLECFGNG
                     HCPGGLTCRGNRCEGSGPLCAPCTGDWQCAPDTHCEVLPEGNAACVARCTPGAGAPPPS
                     QDTRDDRATQCAPGFTCQSDRCLPDAANFAGCHALRRMDAPCTDDASCHELGLLSGRCV
                     SGACTVPCATDRDCPGSRRCVTSSVGDVCQVGT"
     gene            3997..4245
                     /locus_tag="MYMAC_RS24365"
                     /old_locus_tag="MYMAC_004835"
     CDS             3997..4245
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MYMAC_RS24365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MYMAC_004835"
                     /product="hypothetical protein"
                     /protein_id="WP_095959827.1"
                     /transl_table=11
                     /translation="MARQGGSRRRLVVVALSAFATGGLRTRPPRLEVSPGQAAAFVATV
                     EDAEEGLPDPDVSALLVAEEGVRYVGTARGLVTYPCH"
     gene            complement(4267..5004)
                     /locus_tag="MYMAC_RS24370"
                     /old_locus_tag="MYMAC_004836"
     CDS             complement(4267..5004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013941507.1"
                     /locus_tag="MYMAC_RS24370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_004836"
                     /product="putative DNA-binding domain-containing protein"
                     /protein_id="WP_095959828.1"
                     /transl_table=11
                     /translation="MKPSLRAFFDSMGAYLAQPGPASLTALYARHPGWDAPRERVALYG
                     GFVLGHVRAALEKVFPLTRQAVTPDAWDALVAGFTRTRPARHHELNHLGEGFPAFLSDE
                     VSSRALAPFLPALARFEWTDFAVFASEAPAPPRVARLTANPTLVVLEQDFRLCAYVRAR
                     GAPSPPEAGAELALLWRHPEQLRTFYMAATPPALLVLKMAVEGLALEDVVAATGLADAE
                     LRATVTRFGRDGLVLLPEDAARG"
     gene            complement(5001..5846)
                     /locus_tag="MYMAC_RS24375"
                     /old_locus_tag="MYMAC_004837"
     CDS             complement(5001..5846)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015350979.1"
                     /locus_tag="MYMAC_RS24375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_004837"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_239988984.1"
                     /sec_met_domain="DUF692 (E-value: 2e-95, bitscore: 317.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTYAQRHGLKPLGAGIGLRRSFYAELPRTGRALDWVEIIPENFL
                     SLGGRSQRALEACAERWPVLPHGVGLNIGGPDALDDDYVRGLAALVKRVDAPFFSDHLC
                     YSRLDGVYLHDLLPLPFSEAAVEHVVPRVREVMERVGRPFLLENPSYYARMPGGTLQEA
                     DFLRHVVEQADCGLLLDVNNVYVNARNHGYDARAFVDALPLERVVQIHLAGHTRYPDVI
                     VDTHGDRVCDDVWSLYRYVLARTGPVATLIEWDQDIPSLDAVLDEADVARAALREATSR
                     "
     gene            complement(5930..6184)
                     /locus_tag="MYMAC_RS24380"
                     /old_locus_tag="MYMAC_004838"
     CDS             complement(5930..6184)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015350980.1"
                     /locus_tag="MYMAC_RS24380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_004838"
                     /product="hypothetical protein"
                     /protein_id="WP_013941509.1"
                     /transl_table=11
                     /translation="MNVKALAAVVGTLSLTALATGCATKKSAEMEPATAEETGAESSGA
                     TEMQEGQEAAPAATEEKGAEGSCGAGSCGAGSCSGQKQE"
     gene            complement(6251..7675)
                     /locus_tag="MYMAC_RS24385"
                     /old_locus_tag="MYMAC_004839"
     CDS             complement(6251..7675)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013941510.1"
                     /locus_tag="MYMAC_RS24385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_004839"
                     /product="hypothetical protein"
                     /protein_id="WP_239988985.1"
                     /transl_table=11
                     /translation="MFARVRAAAVLLLGVTLLSCHAPVRRGRPAEDAATLRYHLTYVRE
                     PEHAVDVEVVRVGRAPREFLFSQPGAVASVSAFLEDGTVRTLAVEEGRVLLPRDTRFLR
                     YRYALDAVIRKRGLDFFQGSGDGDARHVAGRAYLIRPRVVPPGMRVELSVAGTDALLPW
                     QPGENGVYRLRGEDLVDSGFHGFGGRRCQVRLPDAVLDVAILGRFTHLSDAAVCTWLGK
                     AAEEVRTVRRAFPHPRITVRVIPAPGHPGPSVFGMVRWSSPPSISISVGQDARAEDFER
                     DWVALHEMLHLAHPVFVPRVPWLSEGLATYYTEVARARSGRQSPRRAWEELLGGFARGR
                     DGNDTRTMHEAVSQDGFSLAVYWTGALFALHLDVELRRLTGNTRGLDDVLERLAARGGS
                     STFGAFGVAVDAVAGQPLFNALLERHLSQPAFVEQAGLLEALGVQEGPNGVSLVPGRDS
                     LLRDSVVGRRSHGETP"
     misc_feature    8018..8034
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    complement(8184..8198)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.95"
                     /tool="antismash"
     gene            8277..9902
                     /locus_tag="MYMAC_RS24390"
                     /old_locus_tag="MYMAC_004840"
     CDS             8277..9902
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011554936.1"
                     /locus_tag="MYMAC_RS24390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_004840"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_095959831.1"
                     /transl_table=11
                     /translation="MNDNALNANVGLKLRGLRLARNIKQADAAKDLGVSPAYLNLIEKG
                     KRVMPFPLLWKALRYFDQDPEQFMSTLGEGRVDEALAKLLDEPLLKSLDIDPESLQSLS
                     AEPKLAGTVAALFNLYKNTRTQLENVLAQLNVEERTRAQGGLGGNGAAPGVRFDYSPFD
                     EVSDFLEKHRNYFPELEEQADALRRDVRLERQLTSGQLIRLLEERFGYRVLFDDPSPSG
                     SSVVRRLDPEERTLTLSPFLTEQPLKFQIAASIGLLVMDREKLLERVLDAGRMRHGETQ
                     RLIKVNLANYFAGALMLPYGDFFKEVQRTRYDVELLSSIFGSTYETVAHRLCNLSDPKR
                     PGIPFHFLRADIAGNISKRYSGTGIRFASGGGSCAKWAVHLAFLNPSQLTRQYSIMPDG
                     TAYFCFAKVQLQPIEGSIVKGTAYSIGLGTHAENAKYLAYGLPTTDLRKDAIPSGISCR
                     FCERTDCNQRAAASYRFAFAFDEYTKKDCFFSPILVHEKADKAEKDRGHGAHALHAANG
                     NGTDGSEKDDLLDKTSRRRKGGDA"
     gene            9911..10786
                     /locus_tag="MYMAC_RS24395"
                     /old_locus_tag="MYMAC_004841"
     CDS             9911..10786
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011554937.1"
                     /locus_tag="MYMAC_RS24395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_004841"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_095959832.1"
                     /transl_table=11
                     /translation="MHHPTEDTQRTHILDAIQKQKNALAPLRITGSPTEVGQGLVNLAE
                     LHGLLEDHAASRQFYEEALEKFQEAKYKPGQAQALMGLGIVKANFEDHRGAIEQIARAA
                     MLFNESKDREGEALARACIGESLRSLGQPEAAEEKYQEALILLRQTRNSERVARLLIDI
                     GDIRMEKGEYEPARKRFLEAVPLLEQGDDAEALALGHLLLGESEGLLGNHEGARPHLLR
                     AVELYLELHDHAYEARARWDLGLSCYYQQDYAAARKQFETLIPLYEDLKQTGEVAKVRN
                     ILAHFTARGV"
ORIGIN
        1 tcgtgcgggc cttccgggcg ctgccgcggc tgaaggagcc gggggccttc gagtcctggc
       61 tcctgtccat tgcccgcaac cgggcccgga cgcggctgga gcggaagtcg aacacccggc
      121 ggctggaggg agacgtggcg gacccggaac cggagacggt cccccacatt cccgaggccc
      181 tgcagttgga gcgtgacatc gaggtggtgc ggcggctcat cgcggagctg cccgagggcg
      241 aggagaaacg gacggtgcag ctcttctaca tcgagggtga actgtccgcg cgtgagatcg
      301 cggagaagct gggcgtggga aagagcgcgg tgacgatgcg gctggaacgg ttccggtctc
      361 gaatcaagcg cgagctgttg cggcgagtcc tcgccggccg gtgggagtga gtgcgcatga
      421 gacacctgga tgacgtcgcg ctgagcgccc tttcccgccg cgagccggag gccgtggcgt
      481 acttcgccga gcacctggcg cacccgtgcg acacctgcga ggcgttcctc gccgcgcacg
      541 cgggcccgga cttgctcgac ggacaggtgg acgcgctgct gctggggctc gccccgcccg
      601 cggcgtccgc ggcgcccctt gatgaagtgg gcctggcgcg ggtgcggcgc gcgctgagga
      661 cccacccacc cgcggcccgg cggtggggcc tggtcgccgg agggctcgcc gcgtgcgtgc
      721 tggcgctggt gctgctgccc cgcatgcgcg cggaggcccc gggcccccag acgggcgcgc
      781 ccgggccatg gacgggtgag aaggggcgcg tggcgcacat cgccctggag ctgtcggtgg
      841 cggcacgcgc cagcgacggg gtgctgcgac ggctggatcc aggcagccgg gtggaggact
      901 ccgacgtgct gctgctgcgc taccacgcca ccgaggcggg cagcgccctg ctcttcgtgc
      961 agcgccaggg tgagccgccg gagctgctgg gccagttccc gctgaccgcg ggcacccatg
     1021 acctgcgagg cccacaaggg ctggcgggcg tgagcctcac gggcgaaacc ggcccggtga
     1081 cgctgtggct ggtgggcgcc gagggcgcgc cgccggacac gcgcgtggtg cgggaaatgt
     1141 tggagggcca gaccgcgcca ggcgcactgg cggtcatccg gttcgacgtg agcgtgagaa
     1201 gcggccagaa tcgtccttga acggttccac gtgaggcgac tccttcccat cctcctggca
     1261 tgcctggccg catgcgccgc gccctcctcc ggggagaagg gcggcctggt gccgctcacg
     1321 ctcgatgagg cctcgctgtc cagcgcctac aagccgcgcc ggatggccct gctggtgggc
     1381 atctcctcgt tcgacgaccc gcgctggcgg gggctgcgct acaccggcaa ggacgcgcgg
     1441 gacctgggcg ccgccctgag cgatcccgcg cggggccatt tcgaccacgt gcgcgtgctc
     1501 acccgccgcg aggagacgac gcgcacggcc atcctcgccg cgctccggca gctcaagcag
     1561 gaggccaacc ggccggatga cgtggtggtc gtctacttct ccgcgcacgg cacgctggcg
     1621 cgcgacgcga aaggcgagct gcggcgctac ctggtcaccc gcgacgcgtc gtaccggaac
     1681 atcccccaga cggcgctcgg catggacgcg ctgaaggcgg agttcgacgg gctggccagc
     1741 cggcgccgca tgctggtgct ggccacctgt cacagcggca gcggcaagtc cctgctgccc
     1801 agggagctga aggcggagct ggagggcatc aagtccggct tctacgcccg gcccctggag
     1861 gagtcgtcgc gcgcgtccat ggtgttcgcc gcctgcgact ggggtgagac ggcgcgcgag
     1921 gacgagagcc tgcgcaacga catctacacc cacttcctca tcgacggcct gagcggcgcg
     1981 gcggaccgca atggtgacgg cgccgtcacg gccaccgagg cccacgacca cgcccgccgc
     2041 cgcaccttcg ccttcacgga gggacgccag cgtccgtcag cggaaatcct ggaagtgggc
     2101 gcggacccgg tggtgctctc cggcagcatc acccggagcg gccgcccgga gctgttctcc
     2161 tacaacccgc gcctggacgg cttcacgctc aaggtggacg gcgaggcgcg cacggagctg
     2221 cccggcggcg cggcggtgcc ccccggtaga cggacggtgg agctgaccaa gggtgacgcc
     2281 gtcctcatgc gccgcgacgt ggaggtgggc cagggagacc ggctgcccct ggagcggttg
     2341 ctggcgcagg ccttcccccg gcgctcgctg tcgctgctgg gggggatgtt ctccttcgcg
     2401 gacgcgcgca gccgcgccga gctgctgccc gtctccccgg aggtcgcgct gtccctgcgc
     2461 ctggaggaca aaccgctgga ggatttcggc ctcctcttcg acgtggcctt cagcaccggc
     2521 caacggcacc tgcgcctgac accggggagc gaggtgccct tccggtacac cacgttcgcc
     2581 gcgggcgccg ccctgcccta cctgtggcga tgggagcggc tgacggtgtt cgcgggcccc
     2641 cgcgtggccg gcctgtacct gaggcggtcc tttgacgtag aggccgccgc cacggggcaa
     2701 cggttcttca ccgtcagccc cggcgtggtg ggcggcatcg tgtggcgcgt gggtgagcgg
     2761 ctggagctga tgtcgcaggc ccagctcatg ttgacgtatg tcgtggtgga cgggcagggg
     2821 caggccgtgg gtttcacggg tggctgggct ggcgcgggat atcgcttttg atgcgctcga
     2881 cgtttcacat cgcggtcgcc accctcctga cgtgcgtcgc ggcgggctgc gggaacctgg
     2941 agaacgcgcc cttccgcgtg ggcaccgttc atgggcagct cacggagagc gaccccgcgg
     3001 tggccatggt gtcgctggtg gagcagcccg gcgtgagcag ccacgtcgac gctgacgggc
     3061 acttcaccct gcgggacgtc ccgtcggggc ccgccgagct cttcatcgtc gccacctcgg
     3121 agaaggccgc gcgcgtccag gtgcaggtgc cgggaggcca gtccgtccgg gtgcggccgg
     3181 tggaacccac gcccgcgggt ttcttcgacc tgcgggtgaa gacgaccaac gggttccggc
     3241 tgcctgcgac ggaggtctcc gtggagggca cgcccttcca gcggctcctg ctggatgcgc
     3301 agggccggct gcgcgtgggc ccgctgccgg acggctgcta cgccgtgtcg gtgacggcca
     3361 ttggctttcc gcgcacccag accgaggctt gcgcgggtcc gggagagcgg aaggagctca
     3421 aggtcgacct ggaggtggac gcgtcgctgc tcgagcaggg ctgccaggag catggctgcg
     3481 aggagggcct ggtgtgcgcg ccgaacaaga agtgcctgga gtgcttcggc aacgggcact
     3541 gcccaggggg gctgacctgc aggggcaacc gctgcgaggg ctccgggccc ctgtgcgccc
     3601 cctgcacggg cgactggcaa tgcgcccctg acacccactg cgaggtgctc cccgagggga
     3661 acgcggcgtg cgtggcccgg tgcacccccg gcgccggtgc ccctcccccg tcccaggaca
     3721 cgcgggacga ccgcgcgacg cagtgcgcgc cgggcttcac ctgccagtcc gaccgctgcc
     3781 tgccggatgc cgcgaacttc gcgggctgcc acgccttgcg caggatggac gcgccctgca
     3841 ccgacgacgc gagctgccac gagctggggc tgctgagcgg gcgctgcgtc agcggggcct
     3901 gcacggtgcc ctgcgccacg gaccgcgact gcccgggcag ccggcggtgc gtgacgtcgt
     3961 cggtgggcga cgtctgccag gtcgggacgt gacaccgtgg cgcgccaggg tggctcgcgg
     4021 cgtcgcctcg tcgtggtcgc cctgtccgcc ttcgccacgg gggggctgcg aaccaggccc
     4081 ccgcggctcg aggtctcccc cggccaggcc gctgcgttcg tggccaccgt cgaggacgcg
     4141 gaggaagggc tgccggaccc ggacgtgagc gccctgctcg tggcggaaga gggcgtgcgc
     4201 tacgtgggca cggcgcgggg cctggtgacg tacccctgcc attgagcgcc cggaccgcgg
     4261 gggcgctcac ccccgggcgg cgtcctccgg gagcagcacc aggccgtcgc ggccaaagcg
     4321 cgtcaccgtc gcgcgcagct ccgcgtccgc caggcccgtg gccgccacca cgtcttccag
     4381 ggcgagcccc tccaccgcca tcttcagcac cagcagcgcg ggcggcgtgg cggccatgta
     4441 gaaggtccgc aactgctccg gatggcgcca cagcagcgcc agctccgcgc ccgcctcggg
     4501 gggactcggg gcgccccggg cccgcacgta ggcgcacagc cggaagtcct gctccagcac
     4561 caccagcgtg gggttggccg tcagccgcgc cacgcgtggg ggggcgggag cctcggaggc
     4621 gaacacggcg aagtcggtcc actcgaagcg ggccagcgcg ggcaggaagg gcgccaacgc
     4681 ccgcgaggac acctcgtccg agaggaacgc ggggaagccc tcacccaggt ggttgagctc
     4741 gtggtgccgc gcgggccggg tccgcgtgaa gcccgccacc agcgcgtccc atgcgtccgg
     4801 cgtcaccgcc tggcgcgtca gcgggaacac cttctccagg gccgcgcgca catggccgag
     4861 cacgaagccg ccgtacagcg ccacccgttc gcgcggcgcg tcccacccgg gatgcctcgc
     4921 gtacagcgcc gtcaacgacg ccggaccggg ctgggcgagg taggccccca tgctgtcgaa
     4981 gaaggctcgc agggagggct tcatcgcgac gtggcctccc gcagcgccgc tcgcgccacg
     5041 tccgcctcgt ccagcaccgc gtccagcgag ggaatgtcct ggtcccactc gatgagcgtc
     5101 gccaccgggc cggtgcgcgc cagcacgtaa cgatagagcg accacacgtc gtcacagacg
     5161 cggtcgccgt gcgtgtccac gatgacgtcc gggtagcgcg tgtggcccgc caggtgaatc
     5221 tgcaccacgc gctccagcgg cagcgcatcc acgaaggccc gcgcgtcgta cccatggttg
     5281 cgcgcgttga cgtagacgtt gttcacgtcc agcagcagcc cacagtccgc ctgctcgacg
     5341 acgtggcgga ggaagtccgc ctcctggagc gtgccgccgg gcatccgcgc gtagtagctg
     5401 gggttctcca gcaggaaggg acggcccacc cgctccatga cctcgcgcac gcggggcacc
     5461 acgtgctcca ccgcggcctc gctgaagggc agcggcagca ggtcatgcag gtacacgccg
     5521 tccagccgcg aataacagag gtggtccgag aagaagggcg cgtccacccg cttcaccagc
     5581 gccgccaggc cgcggacgta gtcatcatcc agcgcgtccg gaccgccgat gttcaacccc
     5641 acgccgtggg gcagcacggg ccaccgctcc gcgcacgcct ccagcgcgcg ctgcgagcgc
     5701 ccgcccagcg acaggaagtt ctccggaatg atttcaaccc agtcgagcgc ccgtccggtc
     5761 cgtggaagct ccgcgtagaa gctcctgcgc agcccgatgc ccgcgcccag tggcttcaac
     5821 ccatgtcgct gtgcgtacgt caccacggcg cgagcccgct ccatgcgagg ggaaacggcc
     5881 cgggcggcgg aagattcctc cagccgcccg gaaccgggag acagcggaac tactcctgct
     5941 tctggccgct gcacgagccc gcgccgcacg agccggcgcc acagctcccc tcggcgccct
     6001 tctcctcggt ggcggcgggg gcggcctcct ggccctcctg catctccgtc gcaccgctgc
     6061 tctcggcgcc cgtctcctcc gccgtggcgg gctccatctc agccgacttc ttggtcgcgc
     6121 agccggtggc cagcgcggtg agggacaggg tgccaacaac cgctgcaagc gccttgacgt
     6181 tcatggttcg ggacttcctt tcggactgct catactgcgt gggggtgttg tgcggaggtc
     6241 gtgagtgcat tcagggtgtt tcgccgtggc tgcgccgacc gaccaccgaa tcacgcaaca
     6301 gactgtctct gccgggcacc agcgagacgc cgttgggtcc ttcctggaca cccagcgctt
     6361 ctagcagacc ggcctgctcc acaaaagcag gctgggacaa gtgccgctcc agcagagcat
     6421 tgaacagcgg ctgtcccgcc accgcgtcca ccgcgacacc gaatgcgccg aaagtcgagg
     6481 aaccgccgcg cgcggcgagc cgctccaaca cgtcgtccag cccgcgcgtg tttccagtga
     6541 gacggcgcaa ttccacgtcg agatgcaacg cgaagagcgc tcccgtccaa tagacagcga
     6601 gcgagaagcc gtcttgagac acggcctcgt gcatggtgcg cgtgtcattg ccgtcgcggc
     6661 cccgggcgaa gccgcccagc agttcctccc aggcgcgccg cggcgactgc cgtccggagc
     6721 gggcgcgcgc gacctccgta tagtaggtgg ccaaaccttc tgacagccag ggaacgcgcg
     6781 gcacgaagac ggggtgggcc aggtgcagca tctcgtgcag ggccacccag tcccgctcga
     6841 agtcctcggc ccgcgcgtcc tgccccacgc tgatggagat gctgggcggc gagctccagc
     6901 gcaccatgcc gaagacgctg ggccccgggt gtcccggtgc ggggatgacg cgcacggtga
     6961 tgcgcgggtg tgggaaggcg cgccgcacgg tgcggacctc ctcggcggcc ttgcccagcc
     7021 aggtgcacac cgccgcgtca ctcaggtgcg tgaagcgccc caggatggcc acgtccagca
     7081 ccgcgtccgg aaggcgcacc tggcaccgcc gcccgccgaa gccgtggaag cccgagtcca
     7141 ccaggtcctc gccccgcagc cggtacacgc cgttctctcc cggctgccag ggcagcaacg
     7201 cgtcggtgcc cgccaccgac agctccacgc gcatgcccgg cggcaccacc cgcgggcgga
     7261 tgaggtacgc ccggcccgcg acgtgacgcg cgtccccgtc ccccgaaccc tggaagaagt
     7321 cgaggccgcg ctttcggatg acggcgtcca gcgcgtaccg gtagcgcaag aagcgcgtgt
     7381 cccgaggcag caggacgcgc ccctcctcca cggccagggt ccggaccgtc ccgtcctcca
     7441 ggaaggcgga caccgacgcc acggcgcccg gctggctgaa gaggaactcg cgcggcgcgc
     7501 gtcccacccg caccacctcc acgtccaccg cgtgctcggg ctcgcgcacg taggtgaggt
     7561 ggtagcgcag cgtcgccgcg tcctccgcgg gccgcccccg acgcaccggc gcgtggcagg
     7621 acaacagcgt cacgcccagc aggagaacgg cggcggcccg gacgcgcgcg aacaacggcg
     7681 ccctgcccca cctccacggc cctccatgcc caccgtccat atgcggcgaa ggttcgccca
     7741 tgccgcgccg gaggtgaacg gtggagggag ggcccggggg cgcgggccaa cacccggcgg
     7801 acaccagcgc acacgccctg ggacggcggg gcaggaggcc caccgggctc agcggacctc
     7861 ctccccggcg agcgccgtca tgaaccacgc gcccggcctc gggggccccc acgtgtccct
     7921 cggctcccgc cgcagatcac ccgccgggtc cgacacaggc ctgtaaatcc gcgctttcaa
     7981 ctttaccaac gcgtcacgcg gggatgccgc gatgcatcag taaatgtttg acaaggggcg
     8041 gggaggggcc gggcggcagg ccgccgccac gccacaaagc gcagtgattc cagccagttg
     8101 aaccatcacc cacccgggtc tccgaccccg ggccagccgg tccgtcgccg ggccgacagg
     8161 ggtccccggc gccgaaatcg atgattgcaa atcggtaaat cgatttgcag agtgggtgag
     8221 gtgccccagg cgcgcgcggc cattcgcgat cgccgggggc gtcatctcat ccggccatga
     8281 acgacaacgc actgaacgcc aacgtgggcc tgaagcttcg gggactgcgg cttgcccgga
     8341 acatcaagca agcggacgcg gccaaggacc tgggcgtttc cccggcgtac ctgaacctga
     8401 ttgagaaggg caagcgggtg atgcccttcc ccctgctgtg gaaggccctg cgctacttcg
     8461 accaggaccc cgagcagttc atgtccacgc tgggcgaagg ccgcgtggac gaggcgctcg
     8521 cgaagctcct ggacgagccg ctcctcaaga gcctggacat cgacccggag tcgctccagt
     8581 ccctctccgc ggagccgaag ctcgcgggca cggtggcggc gctcttcaac ctctacaaga
     8641 acacccgcac gcagttggag aacgtgctgg cgcagctcaa cgtggaggag cgcacgcgcg
     8701 cccagggcgg gctggggggc aacggcgccg cgcccggcgt ccgcttcgac tactcgccct
     8761 tcgacgaggt cagcgacttc ctggagaagc accgcaacta cttcccggag ctggaggagc
     8821 aggcggacgc gctgcgccgc gacgtgcgcc tggagcggca gctcaccagc ggccagctca
     8881 tccggctgct ggaggagcgc ttcggctacc gcgtcctctt cgacgacccg tcccccagcg
     8941 gctcgtccgt ggtgcggcgc ctggacccgg aggagcggac gctgacgctg tcgcccttcc
     9001 tcaccgagca gccgctgaag ttccagatcg ccgcgtccat tggcctgctg gtgatggacc
     9061 gcgagaagct gctggagcgc gtgctggacg cgggccgcat gcgccacggc gagacgcagc
     9121 ggctcatcaa ggtgaacctg gccaactact tcgccggcgc gctgatgctg ccctacgggg
     9181 acttcttcaa ggaggtgcag cgcacgcgct acgacgtgga gctgctctcc agcatcttcg
     9241 gctccaccta cgagacggtg gcccaccgcc tgtgcaacct gtcggacccg aagcggccgg
     9301 ggattccctt ccacttcctg cgcgcggaca tcgccggcaa catctccaag cgctacagcg
     9361 gcaccggcat ccgcttcgcc tcgggcggcg ggagctgcgc caagtgggcc gtgcacctgg
     9421 ccttcctcaa cccgtcccag ctcacgcggc agtactccat catgccggac ggcaccgcct
     9481 acttctgctt cgccaaggtg cagctccagc ccatcgaagg ctccatcgtc aagggcaccg
     9541 cgtactccat tggcctgggc acccacgcgg agaacgccaa gtacctggcc tacggcctgc
     9601 ccaccacgga cctgcgcaag gacgcgattc cctccggcat ctcctgccgc ttctgcgagc
     9661 gcaccgactg caaccagcgc gcggcggcca gctaccgctt cgccttcgcc ttcgacgagt
     9721 acacgaagaa ggactgcttc ttctccccca tcctggtcca cgagaaggcc gacaaggcgg
     9781 agaaggaccg cggccacggc gcccacgccc tgcacgcggc caacggcaac gggactgacg
     9841 ggagcgagaa ggacgatttg ttggacaaga cctcccgccg ccgcaagggt ggcgacgcct
     9901 gaggcccccc atgcaccacc ccaccgaaga cacccaacgc acccacatcc tcgacgccat
     9961 ccagaagcag aagaacgcgc tggcgccgct gcgcatcacc ggctcgccca ccgaggtggg
    10021 ccagggcctg gtgaacctgg ccgagctgca cggcctgctg gaggaccacg ccgccagccg
    10081 gcagttctac gaggaggcgc tcgagaagtt ccaggaggcc aagtacaagc ccggccaggc
    10141 gcaggccctg atgggcctgg gcatcgtgaa ggcgaacttc gaggatcacc gcggcgcgat
    10201 tgagcagatt gcccgcgccg ccatgctctt caacgagtcc aaggaccgtg agggcgaggc
    10261 cctggcccgc gcctgcatcg gtgagtccct gcgctcgctg gggcagccgg aggccgccga
    10321 ggagaagtac caggaggcgc tcatcctgct gcgccagacg cgcaactcgg agcgggtggc
    10381 gcggctgctc atcgacattg gcgacatccg catggagaag ggcgagtacg agcccgcccg
    10441 gaagcgcttc ctggaggccg tgccgctcct ggagcagggc gacgacgcgg aggcgctcgc
    10501 gctggggcac ctgttgctgg gcgaatcgga ggggctgctt ggcaaccacg agggcgcgcg
    10561 cccgcacctg ctccgcgcgg tggagctgta cctggagctg cacgaccacg cgtacgaggc
    10621 ccgcgcccgg tgggacctgg gcctgtcctg ctactaccag caggactacg cggcggcccg
    10681 gaagcagttc gagacgctga ttccgctcta cgaggatttg aagcagacgg gtgaggtggc
    10741 caaggtgcgg aacatcctgg cccacttcac cgcgcgcggc gtgtgagcgc tcttcccagg
    10801 caggcggaga gcgcccgcac acgcgcgctt cgctacgcgt ggatgc
//
