LOCUS       NZ_CP022203            10864 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Corallococcus macrosporus DSM 14697 chromosome, complete genome.
ACCESSION   NZ_CP022203
VERSION     NZ_CP022203.1
KEYWORDS    RefSeq.
SOURCE      Corallococcus macrosporus DSM 14697
  ORGANISM  Corallococcus macrosporus DSM 14697
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Myxococcaceae; Corallococcus.
REFERENCE   1  (bases 1 to 8973512)
  AUTHORS   Rupp,O., Goesmann,A. and Sogaard-Andersen,L.
  TITLE     Sequencing and comparative analysis of myxobacterial genomes
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8973512)
  AUTHORS   Bruckskotten,M., Treuner-Lange,A., Rupp,O., Goesmann,A. and
            Sogaard-Andersen,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-JUN-2017) Department of Ecophysiology, Max Planck
            Institute for Terrestrial Microbiology, Karl von Frisch Str. 10,
            Marburg, Hessen 35043, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 09-AUG-2016
            Assembly Method                   :: Celera Assembler v. 8.1
            Expected Final Version            :: yes
            Genome Coverage                   :: 83.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002305895.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 03:36:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,344
            CDSs (total)                      :: 7,262
            Genes (coding)                    :: 7,199
            CDSs (with protein)               :: 7,199
            Genes (RNA)                       :: 82
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 26 of 63
            Pseudo Genes (incomplete)         :: 45 of 63
            Pseudo Genes (internal stop)      :: 2 of 63
            Pseudo Genes (multiple problems)  :: 10 of 63
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:23:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4173756
            Orig. end                         :: 4184620
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP022203.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10864
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="10"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10864
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10864
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5864](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5864)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            190..1020
                     /gene="rsmI"
                     /locus_tag="MYMAC_RS17620"
                     /old_locus_tag="MYMAC_003494"
     CDS             190..1020
                     /EC_number="2.1.1.198"
                     /GO_function="GO:0008649 - rRNA methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0000451 - rRNA 2'-O-methylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsmI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011553581.1"
                     /locus_tag="MYMAC_RS17620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_003494"
                     /product="16S rRNA (cytidine(1402)-2'-O)-methyltransferase"
                     /protein_id="WP_095958910.1"
                     /sec_met_domain="TP_methylase (E-value: 4.6e-30, bitscore:
                     103.9, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGTLYLVATPIGNLGDVTSRALETLRSVRFIACEDTRHSRVLLD
                     HFGIGGKDLVSLPAFAEGQRAGRILDRMGEGEDCALVTDAGSPAISDPGEKLVAEALER
                     GFTVVPVPGPTALVAALSASGLPTGRFHFLGFLPRKGAERRAMLEEVAQLSATLVLYES
                     PRRLSETLPDLLDAWGNRRACVARELTKLHEEFARGTLSELAERYAAEAARGEVVVLVE
                     GRTGETRWSEEELRKALEEGLSRGEKLKALSTELARRAGWAGQDVYRLGLSLKR"
     gene            complement(1058..2341)
                     /locus_tag="MYMAC_RS17625"
                     /old_locus_tag="MYMAC_003495"
     CDS             complement(1058..2341)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011553582.1"
                     /locus_tag="MYMAC_RS17625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_003495"
                     /product="hypothetical protein"
                     /protein_id="WP_095958911.1"
                     /transl_table=11
                     /translation="MHRLRVVLAALTLGAPFAASAADITRIASSLEEDDPFDLFIDVGF
                     ERTQNRAKIVREQLAPTGQPGGRVDASELWYKGVDARLNLELSVGLYRDLEFSFALPIV
                     FSQNERWDFTSNSSPESSTITNNCVNADGSVISGCLDGTAPPSALFDVPQESFRGGLGN
                     MRFGLAYAFFNQEKDETKPTWIVGLEYEAPTAKLRDPSADTTNSDSRGNIGDRVHKYQL
                     YTAFSRRMGAAEPYFKAHYTIPVRGPGAYSNCTHPSNLGQPGNCNTGPWDRKETGINAP
                     HQAGMLFGVELVPFNRPAKSQRFALDVRGIGNYVGSGRYYNELSAALRKLLTSDDYFQV
                     GGMLGITANASKAFQIRASGTFLYNTNRALTAEDLGQDVDGNGEVDLQPGSPELNPNFD
                     WRYDLVSRRFLAMESTTFRFDLSATFSF"
     gene            complement(2441..3607)
                     /locus_tag="MYMAC_RS17630"
                     /old_locus_tag="MYMAC_003496"
     CDS             complement(2441..3607)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011553583.1"
                     /locus_tag="MYMAC_RS17630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_003496"
                     /product="M23 family metallopeptidase"
                     /protein_id="WP_095958912.1"
                     /transl_table=11
                     /translation="MACATPPQTGRKTARTNRRRRGGIPLRARRFRARPPIPTQGACMR
                     PNLPTLGAPPKRSPFGPVVAVSLILGGAAGGVWWWKQRMAQATEEAAAQTLNAAPDAGA
                     VAAAPTPAPVVTDPVKAAGLERVSVSITGPLETALVGAAGADVGPALAQVVTRTLVWWV
                     AVPSEILRNDTLEVLFERRVNEEPLVHAVRFTSGKLGKTLSAYRYQPDGEPNARYYLSS
                     GDELELRLERSPIDDYEQVTSLLRDGRRHKGVDFRTPVGTPIKAPFNGVVKRKNWNFGS
                     NGNCIELVESGGKGRRALFLHLDEVDKSVKPGSRFSVGQVIARSGNTGRSFAPHLHYQL
                     MTQNDRVLDPYEQHKTYRRSLASQHRPGFEAEMRRMDGLLSAAVVAGK"
     gene            complement(3555..4979)
                     /locus_tag="MYMAC_RS17635"
                     /old_locus_tag="MYMAC_003497"
     CDS             complement(3555..4979)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1112: sigma-54
                     dependent trancsriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013940152.1"
                     /locus_tag="MYMAC_RS17635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_003497"
                     /product="sigma-54 dependent transcriptional regulator"
                     /protein_id="WP_095958913.1"
                     /transl_table=11
                     /translation="MAKVLVIDDEANLRKVLAAMLRRDGFDVTVAENGEQGLAEFHKNG
                     ADIVVTDLVMPKVGGMEVLGTIRAANPDVPVIIITAHGTVDSAVDAIKAGAFDYITKPF
                     DQAELSSVVAKAAKTNESARRSVRPDVKARAAIIGDSATIQEVYKIIDKVADTPSTVLI
                     TGESGTGKELIATALHGASSRRDKPFIKINCAAIPDTLLESELFGYERGAFTGAVTSKP
                     GRFELADEGTLFLDEIGEIPVEMQVKLLRALQEGEFERVGGIKTTRVDVRLVAATNRDL
                     QAEIEAGRFRKDLYYRLAVVPISLPALRERRSDIPMLARHFVEKYNRRLNKKIEGIAED
                     AMALLQGYAWPGNIRELENLIERVLLFADGPLITARDLPEPVRQGAGVQAGANLASAVA
                     SLDVPTGEVGLKDIVRMKAAELERDLIVKKLEETGGNVTRAARLLQISRKSLQTKMKEF
                     GLRDTTPDGQEDGPDE"
     gene            complement(5001..5864)
                     /gene="encA"
                     /locus_tag="MYMAC_RS17640"
                     /old_locus_tag="MYMAC_003498"
     CDS             complement(5001..5864)
                     /codon_start=1
                     /gene="encA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_026114001.1"
                     /locus_tag="MYMAC_RS17640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_003498"
                     /product="encapsulin nanocompartment shell protein EncA"
                     /protein_id="WP_013940153.1"
                     /sec_met_domain="Linocin_M18 (E-value: 2.1e-83, bitscore:
                     278.1, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDFLGHAENPLREEEWARLNETVIQVARRSLVGRRILDIYGPLG
                     AGVQTVPYDEFQGVSPGAVDIVGEQETAMVFTDARKFKTIPIIYKDFLLHWRDIEAART
                     HNMPLDVSAAAGAAALCAQQEDELIFYGDARLGYEGLMTANGRLTVALGDWSAAGGGFQ
                     AIVEATRKLNEQGHFGPYAVVLSPRLYSQLHRIYEKTGVLEIETIKQLASDGVYQSNRL
                     RGDSGVVVSTGRENMDLAVSMDMVAAYLGASRMNHPFRVLEALLLRIKHPDAICTLEGA
                     GATDRR"
     gene            complement(5909..6385)
                     /gene="encB"
                     /locus_tag="MYMAC_RS17645"
                     /old_locus_tag="MYMAC_003499"
     CDS             complement(5909..6385)
                     /codon_start=1
                     /gene="encB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_026114000.1"
                     /locus_tag="MYMAC_RS17645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_003499"
                     /product="encapsulin nanocompartment cargo protein EncB"
                     /protein_id="WP_170114743.1"
                     /transl_table=11
                     /translation="MAGPPDSDMDDVARIRLVLARELETINEYEAYARASSHPEVRAFF
                     QHLAAEEKEHVSEAVHMLRMLDSGQNDHFNKPFVPGHFQAAEAPAPATVHVPAPDAPGF
                     SINGRNGRLPSEPPTSLPPQRLVYGLPAPPPAVESHPLTVGSLRRGGGGSSSGR"
     gene            6491..8188
                     /gene="murJ"
                     /locus_tag="MYMAC_RS17650"
                     /old_locus_tag="MYMAC_003500"
     CDS             6491..8188
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0034204 - lipid translocation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="murJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013940155.1"
                     /locus_tag="MYMAC_RS17650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_003500"
                     /product="murein biosynthesis integral membrane protein
                     MurJ"
                     /protein_id="WP_095958915.1"
                     /transl_table=11
                     /translation="MTTSSPESPPPPVAPVTPPRPERSGGGAALVAAGILASRLMGLVR
                     ERVFAHYLGNAEAAAVFKAALRIPNFLQNLFGEGVLSGSFIPVYAQLLGRKDTETADRV
                     AGAVFGILSLATAVVVALGMVFTPFLVDAIAPGFQGQERVLAIHLVRILFPGTGMLVLS
                     AWCLGILNSHRRFLLSYLAPVVWNLVIIVALVAAGGRYAEEALVAVLAHAVVLGSFLQF
                     AVQVPSVLKLLGRFRPSLSLAAEPVRQVLRNFGPVVLGRGVVQFSAWVDTAFASLISNR
                     ALSSLLYAQTLYLIPVSLFGMAVSAAELPEMSRATGEEADVAAKLRQRIDGGARRICFW
                     VVPSAAAFLFLGDMVAAALLQTGRFDAADSRYLWYLLMGAALGLVASTVGRLYASAFYA
                     LKDPKTPLRFAVVRVLVGTLGAWVLGLRLPDWLGLPQHLGAVGLTVASGLVAWLESGLL
                     RRKLVRRLGPVGVPRGLLPRLWGAAVVAGLAALGIKWGLTSLLGPMPGVAAEWGGSLLV
                     PPRLHPVLGFAAVALPFGASYFAVTAALGIPEASAVFRKVGRKLRLVR"
     gene            8461..10398
                     /locus_tag="MYMAC_RS17655"
                     /old_locus_tag="MYMAC_003501"
     CDS             8461..10398
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013940156.1"
                     /locus_tag="MYMAC_RS17655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MYMAC_003501"
                     /product="S1 RNA-binding domain-containing protein"
                     /protein_id="WP_095961606.1"
                     /transl_table=11
                     /translation="MGPKKPKATFGDVMLGIPSGGARGEGGGRGERGGGRGGERGGSGR
                     GEREAQPRPPGGAPRDDRGPRGGGERRGGGERRPSGPMVVVKRASGTIETRGPVGDAPA
                     EATATAEETTAAAESSAATPAPAPRPVTPTPAPTSALYEEVPESQSFAEMFEAQAKDGG
                     TPSRKGLRVGEKVRGTIFQLGADTAFVSVEGAAKSEAMIELRELKDDEGILRFGVGDVI
                     DAHVVEVGAKGIQLSRALAKGSANLALLAEARASGMPVEGLVLSVNKGGVEVAIGDIRA
                     FCPISQLDLRYVEKPDQFIGEKLQFRVSEVRERNVVLSRRALLEDEQRQLAAETRKNLA
                     QGKIVKGKVSGVRDFGVFVDLGGVEGMIPVSELSYTRVGHPSDVVKVGDEVEVEILRME
                     AGQPNSPDKAKQKERITLSMRSRQEDPFQKALSEIKEGDRLQGKVVRLQQFGAFVELRP
                     GVDGLVHISALSDRRVAHPRDVVKEGELIWVSVEKIDTQEKRIGLRRISEEEAQRPPEE
                     RPAAAAEAAPAQSAAPRPKVGQVVMGKVDRIEPYGVFLAFPGGKGLLPASETGTERGTD
                     LRKHYSLGQEVKVAILDIDASGKIRLSVTAAIRAEERAEVEAWQKTQQPQGAGKKGFGT
                     FADLLNKARK"
     tRNA            10500..10573
                     /anticodon=(pos:4184290..4184292,aa:Met,seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="MYMAC_RS17660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="MYMAC_003502"
                     /product="tRNA-Met"
     gene            10500..10573
                     /locus_tag="MYMAC_RS17660"
                     /old_locus_tag="MYMAC_003502"
     misc_feature    complement(10596..10609)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.98"
                     /tool="antismash"
     misc_feature    10597..10610
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.02"
                     /tool="antismash"
     tRNA            10640..10713
                     /anticodon=(pos:4184430..4184432,aa:Met,seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="MYMAC_RS17665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="MYMAC_003503"
                     /product="tRNA-Met"
     gene            10640..10713
                     /locus_tag="MYMAC_RS17665"
                     /old_locus_tag="MYMAC_003503"
ORIGIN
        1 ccttcgcaca gcgtgtcctt cgcgaagcag cgccgggtgg tgaaggcggc gctgcgctac
       61 ctgttcgcgc atgacctgcg cgggcggatg cttcgtttcg atgtgatttc ggtggtgggg
      121 cgcggggagc gcgccaccgt ggagcacatc cctggcgcct tcgacgccgg gatgtgagag
      181 gacgacgcca tggctggaac gctctacctg gtggcgacgc ccatcgggaa cctgggggac
      241 gtcacgtcgc gggcgctgga gacgctgcgc tcggtgcgct tcatcgcgtg cgaggacacg
      301 cggcactcgc gggtgctgct cgaccacttc gggattggag ggaaggacct ggtgagcctg
      361 cccgccttcg cggagggaca gcgcgcgggc cgcatcctgg accggatggg ggagggcgag
      421 gactgcgcgc tcgtcacgga cgcgggcagc cccgccatca gtgacccggg agagaagctg
      481 gtggccgagg cgctggagcg cggcttcacg gtggtgccgg tgccggggcc cacggccctg
      541 gtggccgcgc tgagcgcctc cgggctgccc acgggccgct tccacttcct gggcttcctc
      601 ccgcgaaagg gcgccgagcg ccgggccatg ctggaggagg tggcgcagct ctcggccacc
      661 ctggtgcttt atgagtcccc gcgtcgtctg tcggagacgc tgccggactt gctggacgcc
      721 tggggcaacc ggcgggcctg cgtggcgcgc gagctgacga agctgcacga ggagttcgcc
      781 cgcggcaccc tgtccgagct ggcggagcgc tacgcggcgg aggcggcgcg aggcgaggtg
      841 gtggtgctgg tggagggccg caccggagag acgcgctggt ccgaggagga gctgcgaaag
      901 gccctggagg agggcctgtc gcgcggcgag aagctcaagg cgctgagcac cgagctggcc
      961 cgccgcgcgg gctgggccgg gcaggacgtc taccggctgg gcctgtcgtt gaagcgatga
     1021 gtcccggggg cgccgccgcc ggcgcccccg tcaggcgcta gaagctgaac gtggcgctca
     1081 ggtcgaagcg gaaggtggtg ctctccatcg cgaggaagcg gcgggacacc aggtcgtagc
     1141 gccagtcgaa gttggggttc agctcgggcg agccaggctg caggtccacc tcaccgttgc
     1201 cgtcgacatc ctgacccagg tcctcggcgg tgagggcgcg gttggtgttg tagaggaagg
     1261 tcccggacgc gcgaatctgg aaggccttcg acgcgttggc ggtgatgccc agcatgccgc
     1321 ccacctggaa gtagtcgtcg gaggtgagca gcttgcgcag ggcggcgctc agctcgttgt
     1381 agtagcggcc actgcccacg tagttgccga tgccccgcac gtccagggcg aagcgctggg
     1441 acttcgccgg ccggttgaag ggcaccaact ccacgccgaa gagcatgccc gcctggtggg
     1501 gggcgttgat gcccgtctcc ttgcggtccc acggccccgt gttgcagttg cccggctggc
     1561 ccaggttgct cgggtgggtg cagttggaat aggcgccagg gccgcgcacg gggatggtgt
     1621 agtgggcctt gaagtagggc tccgccgcgc ccatgcggcg cgagaaggcc gtgtagagct
     1681 ggtacttgtg gacgcggtca ccgatgttgc cgcggctgtc cgagttcgtg gtgtccgcgg
     1741 acgggtcgcg cagcttcgcc gtgggggcct cgtactccag gccgacaatc cacgtgggct
     1801 tcgtctcgtc cttctcctgg ttgaagaagg cgtacgccag gccaaagcgc atgttgccca
     1861 ggccgccgcg gaagctctcc tgcggcacgt cgaacagggc ggagggcggc gccgtgccat
     1921 ccaggcagcc ggagatgacg gagccgtccg cgttcacgca gttgttggtg atggtggacg
     1981 actcaggcga cgagttggac gtgaagtccc agcgctcgtt ctgcgagaag acgatgggca
     2041 gggcgaagga gaactccagg tccctgtaga ggccgacgga cagctccagg ttgagccggg
     2101 cgtccacgcc cttgtaccag agctccgacg cgtccacgcg gccaccgggt tgtccggtgg
     2161 gggcgagctg ctcgcggacg atcttcgcgc ggttctgggt gcgctcgaag ccgacgtcga
     2221 tgaagaggtc gaacgggtcg tcctcctcga gcgacgacgc aatccgggtg atgtccgccg
     2281 cgctggcggc gaacggcgcg cccagtgtca gcgctgcaag tacgacgcga agcctgtgca
     2341 tccgacctcc gacgacggcg aaacttccgg gccttccggc aagcccgggg ggcttccagc
     2401 tagccgctcc gtcgaaggag tgtcaagaaa cgggtggctt ttacttgccg gcgaccacgg
     2461 ccgcgctcag cagcccgtcc atgcggcgca tctccgcctc gaaaccgggc cggtgctggg
     2521 aggccaggga gcggcggtac gtcttgtgct gctcgtaggg gtccagcacc cggtcattct
     2581 gggtcatgag ctggtagtgc aggtgagggg cgaagctgcg gcccgtgttg ccgctccggg
     2641 cgatgacctg acccacggag aagcgggagc ccggcttgac gctcttgtcc acctcatcca
     2701 ggtggaggaa cagcgcgcgc cggcccttgc cgccggactc caccagctcg atgcagttgc
     2761 cgttgctgcc gaagttccag ttcttgcgct tcaccacgcc gttgaagggg gccttgatgg
     2821 gcgtccccac cggggtgcgg aagtccacgc ccttgtgccg gcggccatcc cggagcaggg
     2881 aggtcacctg ctcgtagtcg tcgatggggg agcgctccag gcgcagctcc agctcgtcgc
     2941 cgctggacag gtagtagcgg gcgttgggct cgccgtcggg ctggtagcgg tacgcgctga
     3001 gcgtcttgcc cagcttgccg ctggtgaagc gcaccgcgtg caccaggggc tcctcgttga
     3061 cgcggcgctc gaagagcacc tccagcgtgt cgttgcggag gatttcgctc ggcacggcca
     3121 cccaccacac cagcgtgcgc gtcaccacct gcgccagggc cgggcccacg tccgcgcccg
     3181 cggcgccgac cagcgccgtc tccagcgggc cggtgatgct caccgagacg cgctccaggc
     3241 ccgcggcctt gacggggtcg gtgacgacgg gggccggcgt gggcgccgcg gcgaccgcgc
     3301 ccgcgtccgg agcggcattg agcgtctgcg ccgcggcctc ttccgtggcc tgcgccatcc
     3361 gctgcttcca ccaccacacg ccaccggcgg ccccgccgag gatgagtgac acggcgacca
     3421 ccggtccgaa ggggctgcgc ttcggagggg caccgagggt gggaaggttc ggccgcatac
     3481 aagctccctg agttggaatg ggtgggcggg cccggaaccg acgcgcgcga agcggaattc
     3541 cgcctcgccg ccgtctattc gtccgggccg tcttcctgcc cgtctggggt ggtgtcgcgc
     3601 aagccaaact ccttcatctt cgtctggagt gacttgcggc tgatttgaag caggcgagcg
     3661 gcccgggtga cgttgccacc cgtctcctcg agcttcttga cgatgaggtc ccgctcgagc
     3721 tcggcggcct tcatccggac gatgtccttc aggccgactt cacccgtggg gacgtcgagc
     3781 gaggccaccg cgctggccag gttggcgccc gcctggacgc ccgctccctg gcggacgggc
     3841 tccggcaagt cccgggcggt gatgagcggg ccgtccgcga agaggaggac gcgctcgatg
     3901 aggttctcca gctcgcggat gttgcccggc cacgcgtagc cctggagcag ggccatggcg
     3961 tcctcggcga tgccctcaat cttcttgttg aggcgccggt tgtacttctc cacgaagtgc
     4021 cgggcgagca tcgggatgtc gctgcggcgc tcgcgcaggg cgggcaggga gatggggacc
     4081 accgccagcc ggtagtagag gtccttgcgg aagcggcccg cttcaatctc cgcctggagg
     4141 tcgcggttgg tggcggccac gaggcgcacg tccacgcgcg tcgtcttgat gccgcccacg
     4201 cgctcgaact cgccttcctg gagcgcgcgc agcagcttca cctgcatctc caccggaatc
     4261 tcgccaatct cgtccaggaa gagggtgccc tcgtcggcca gctcgaagcg gccgggcttg
     4321 gacgtgacgg cgccggtgaa ggcgccgcgc tcgtagccga agagctcgct ctccagcagc
     4381 gtgtcgggga tggcggcgca gttgatcttg atgaacggct tgtcgcggcg gctggaggcc
     4441 ccgtgcagcg cggtggcgat gagctccttg ccggtgccgc tctccccggt gatgagcacc
     4501 gtggacggcg tgtccgccac cttgtcgatg atcttgtaga cctcctggat ggtcgccgag
     4561 tcaccgatga tggccgcgcg cgccttcacg tccgggcgga cggagcggcg ggcgctctcg
     4621 ttcgtcttcg ccgccttggc gaccacggag gacagctccg cctggtcgaa gggcttggtg
     4681 atgtagtcga acgcgccggc cttgatggcg tccacggcgg agtccaccgt gccgtgcgcg
     4741 gtgatgatga tgacggggac gtccgggttg gcggcgcgga tggtgccgag cacctccatg
     4801 ccgcccacct tgggcatcac caggtccgtc accacgatgt ccgcgccgtt cttgtggaac
     4861 tcggcgagcc cctgctcgcc gttctccgcc acggtgacgt cgaagccgtc ccggcgcagc
     4921 atcgcggcga gcaccttgcg gaggttcgcc tcgtcgtcga tgaccaggac cttggccatg
     4981 gtggaagtcg cggccgcgga ctaccggcgg tccgtggccc cagcgccctc cagggtgcag
     5041 atggcgtccg ggtgcttgat gcgcagcagc agcgcctcca gcacgcggaa cgggtggttc
     5101 atccgcgagg cgcccaggta cgcggccacc atgtccatgg acacggcgag gtccatgttc
     5161 tcccggccgg tggacaccac cacgccggag tccccgcgca ggcggttgga ctggtagacg
     5221 ccgtccgacg cgagctgctt gatggtctcg atctccagca cgcccgtctt ctcgtagatg
     5281 cggtggagct gcgagtacag gcgcggcgac aagacgacgg cgtaggggcc gaagtggccc
     5341 tgctcgttga gcttgcgcgt ggcctcgacg atggcctgga acccgccacc cgccgccgac
     5401 cagtcaccca gcgccaccgt gaggcggccg ttggccgtca tcaggccctc gtagcccagg
     5461 cgcgcgtcac cgtagaagat gagctcgtct tcctgctgcg cgcacagcgc ggccgcgccc
     5521 gccgcggcgg acacgtccag cggcatgttg tgcgtgcgcg cggcctcgat gtcgcgccag
     5581 tgcagcagga agtccttgta gatgatgggg atggtcttga acttgcgagc gtcggtgaag
     5641 accatcgcgg tctcctgctc gccgacgatg tccaccgcgc cgggcgacac gccctggaac
     5701 tcgtcgtagg ggaccgtctg caccccggcg cccagcggcc cgtagatgtc caggatgcgc
     5761 cggcccacca gcgagcgccg ggccacctgg atgacagtct cgttcagacg cgcccactcc
     5821 tcctcgcgga gcgggttctc ggcatgtcca aggaagtcag gcatgaaatg gggctccagg
     5881 ggcgtcaacg tgggaaggga agagggcttc aacgaccgct actggaaccg ccaccaccgc
     5941 ggcgcagcga acccacggtg agcgggtgcg actccacggc gggcggcggc gcgggcaggc
     6001 cgtacaccag ccgctgtggc ggcagtgagg tcggcggctc ggacggcagg cgtccgttgc
     6061 ggccgttgat ggagaagccg ggggcgtccg gcgcgggcac gtggaccgtg gcgggcgcgg
     6121 gggcctcggc ggcctggaag tggcccggga cgaagggctt gttgaagtgg tcgttctgac
     6181 cactgtccaa catgcgcagc atgtggacgg cctcggagac gtgctccttc tcctcggcgg
     6241 ccaggtgctg gaagaacgcg cggacctccg ggtgggagga ggcgcgggcg taggcctcgt
     6301 attcgttgat ggtctccaac tcgcgtgcca gtacgaggcg gatgcgcgcc acgtcgtcca
     6361 tgtcgctgtc gggagggccg gccattggac cggaacctcg caatctggag ggttcggcgt
     6421 caagcgaaac agcgggccgg ggtttcgggc ttcatgccat ccaacggccc gcgtagagtc
     6481 cgccgctctc gtgaccacgt cctcgcctga gtctccgccc ccgccggtcg cgccggtcac
     6541 gcccccccgt cccgagcgct caggtggcgg cgcggcgctg gtggccgccg gcatcctcgc
     6601 ctcccgcctc atgggcctgg tgcgcgagcg cgtcttcgcc cactacctgg gcaacgcgga
     6661 ggccgcggcc gtcttcaagg cggcgctgcg catccccaac ttcctccaga acctgtttgg
     6721 agagggcgtc ctctccggct cgttcattcc ggtgtacgcg cagcttttgg ggcgcaagga
     6781 cacggagacg gcggaccggg tcgcgggcgc ggtcttcggc atcctgtcgc tggccacggc
     6841 ggtggtggtg gcgctcggca tggtgttcac cccgttcctg gtggacgcca tcgcccccgg
     6901 cttccagggg caggagcggg tgctggccat ccacctggtg cgcatcctct tcccgggcac
     6961 gggcatgctg gtgttgagcg cctggtgcct gggcatcctc aacagccacc ggcgcttcct
     7021 gctctcctac ctggcgcccg tcgtctggaa cctggtcatc atcgtcgcgc tggtggccgc
     7081 gggcgggcgc tacgccgaag aggcgctggt ggcggtgctg gcccatgccg tggtgctggg
     7141 cagcttcctc cagttcgcgg tgcaggtgcc ttccgtcctg aagctgctcg gccgcttccg
     7201 cccgtcgttg tcgctggcgg cggagcccgt gcggcaggtg ctgaggaact tcgggccggt
     7261 ggtgctgggc cgcggcgtcg tccagttcag cgcgtgggtg gacaccgcct tcgcgtcgct
     7321 catctccaac cgcgcgttgt cctccttgct ctacgcgcag accctctacc tcatcccggt
     7381 gagcctcttc ggcatggcgg tgtccgccgc ggagctgccg gagatgtcgc gcgccacggg
     7441 ggaggaggcg gacgtggccg cgaagctgcg tcagcgcatc gacggggggg cccgccgcat
     7501 ctgcttctgg gtcgtccctt cggcggcggc cttcctgttc ctgggggaca tggtggcggc
     7561 ggcgctgctg cagacaggcc gcttcgacgc ggcggactcg cgctacctct ggtacctgct
     7621 gatgggcgcg gcgctggggc tggtggcctc cacggtcggc cgcctctacg cctccgcctt
     7681 ctacgcgctg aaggacccga agacgccgct gcgcttcgcg gtggtgcgcg tgctggtggg
     7741 caccctgggc gcctgggtgc tcggcctgcg gttgccggac tggctcgggc tgccgcagca
     7801 cctgggcgcg gtgggcctca cggtggccag tggactggtg gcctggctgg agtcggggct
     7861 gctgcgccgc aagctggtgc ggcggttggg gcccgtcggt gtgccgcggg ggttgctgcc
     7921 tcggctgtgg ggcgcggcgg tggtggccgg actggcggcg ctgggcatca agtggggcct
     7981 cacgtcgttg ctcggcccga tgcccggcgt ggcggcggag tgggggggga gcctgctggt
     8041 gccgccgcgc ctgcaccccg tcctgggctt cgcggcggtg gcgctgccgt tcggtgccag
     8101 ctatttcgcg gtgacggccg cgctgggcat ccccgaggcc tcagcggtgt ttcgcaaggt
     8161 gggacggaag ctgcgtctgg tgcgctaagt gcccgggatt gctcggctcc ttgccatgcg
     8221 gccccagctg atgggtgttt caaccaacgg tccggggatg gcctgacgcg ctgcctccgt
     8281 tatggacgga gcgttggctt gaacggggtg tgcgtcatct ggcttcctcc ccacatggcg
     8341 cgcgtgtaga gtgcgccgcc tttttcaccg gggcccggct tctcgggaag ccagggtcga
     8401 attcgcttca ggaaggtctc ggcagtgagc gacgagaaga acggttccaa ttctggcggg
     8461 atgggtccca agaagccgaa ggccaccttc ggtgacgtga tgctcggcat cccctccggg
     8521 ggagcccgcg gcgagggcgg cggtcggggt gaacgtggcg gtggccgggg aggcgagcgc
     8581 ggcggcagcg gccgtggcga gcgcgaggcc cagccgcgcc ccccgggtgg tgcgccgcgt
     8641 gatgaccgcg gaccccgtgg agggggcgag cgccggggcg gtggtgagcg ccgtccgtcg
     8701 ggccccatgg tcgtcgtgaa gcgggcgtcg gggaccatcg agacgcgcgg cccggtgggg
     8761 gatgctcccg ccgaggcgac cgcgacggcc gaggagacca ccgccgccgc cgagtcctcc
     8821 gccgcgacgc cggcccccgc gccgcgcccg gtgacgccga cgccagcgcc gaccagcgcg
     8881 ctgtatgagg aggtccccga gtcccagtcc ttcgccgaga tgttcgaggc gcaggccaag
     8941 gacggtggca cccccagccg caagggcctg cgcgtgggcg agaaggtccg cggcaccatc
     9001 ttccagctcg gcgcggacac cgcgttcgtg tccgtggagg gcgcggccaa gagcgaggcg
     9061 atgatcgagc ttcgcgagct gaaggacgac gagggcatcc tccgcttcgg cgtgggtgac
     9121 gtcatcgacg cgcacgtggt ggaggtgggc gccaagggca tccagctcag ccgcgcgctg
     9181 gccaagggca gcgccaacct ggccctgctg gccgaggccc gcgcctccgg catgcccgtc
     9241 gagggcctgg tgctgagcgt gaacaagggc ggtgtggagg tcgccatcgg tgacatccgc
     9301 gccttctgcc ccatcagcca attggacctg cgctacgtgg agaagccgga ccagttcatc
     9361 ggcgagaagc tccagttccg cgtgagcgag gtccgcgagc gcaacgtggt gctgtcgcgc
     9421 cgcgcgctgc tggaggacga gcagcggcag ctcgccgcgg agacgcggaa gaacctggcc
     9481 cagggcaaga tcgtcaaggg caaggtctcc ggcgtgcgcg acttcggcgt gttcgtggac
     9541 ctgggcggcg tggaggggat gatccccgtc tccgagcttt cgtacacccg cgtcggtcac
     9601 ccgagcgacg tggtgaaggt cggtgacgag gtcgaggtcg agatcctccg catggaggcc
     9661 ggccagccca actcgccgga caaggccaag cagaaggagc gcatcacgct gtccatgcgc
     9721 tcgcgccagg aggatccgtt ccagaaggcg ctgtccgaaa tcaaggaagg cgaccgcctt
     9781 cagggcaagg tcgtccgcct gcagcagttc ggcgccttcg tggagctgcg cccgggcgtg
     9841 gacggcctgg tccacatctc cgcgctcagc gaccgccgcg tcgcgcaccc gcgcgacgtg
     9901 gtgaaggaag gggagctcat ctgggtgtcg gtggagaaga tcgacacgca ggagaagcgc
     9961 atcggcctgc gccgcatctc cgaggaagag gcgcagcggc ctcccgagga gcgcccggcg
    10021 gccgccgccg aggcggctcc cgctcagtcg gccgcgccgc gtcccaaggt ggggcaggtc
    10081 gtcatgggca aggtggaccg catcgagccc tacggcgtgt tcctcgcgtt cccgggcggc
    10141 aagggcctgc tgcccgcgag cgagacgggc accgagcgtg gcaccgacct gcgcaagcac
    10201 tactcgctgg gccaggaggt gaaggtggcc atcctggaca tcgacgcgtc cgggaagatc
    10261 cgcctgtccg tcaccgccgc catccgcgcg gaggagcggg ccgaggtcga ggcctggcag
    10321 aagacgcagc agccgcaggg cgcgggcaag aagggcttcg gcaccttcgc ggatctgctc
    10381 aacaaggcgc gcaagtagtt ccctggctcc agcgctgatt tcgctgatgt gatcagcgct
    10441 ggagaaaggt gttgacggta caggcgaggg gcggtactta ccgcctcgcc tctctctgcc
    10501 gcggggtgga gcagcctggt agctcgtcgg gctcataacc cgaaggtcgc aggttcaaat
    10561 cctgcccccg caactcgtag cacctcgaaa cctgattgga atgatgatca ggcttcgagg
    10621 cgttgaaccg aaaacatgac gcggggtgga gcagcctggt agctcgtcgg gctcataacc
    10681 cgaaggtcgc aggttcaaat cctgcccccg caactcaggt cggcccggtc attcttctgg
    10741 aatggccggg ccgatttctt ttgggcgtct cgacgccgcg ggcgcattcc accccggccg
    10801 gacagcgtcc aggcgagcgc cgggtgttcg ccagcgaagg cggacccggc accacggtcc
    10861 atct
//
